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https://www.readbyqxmd.com/read/28343606/respiratory-muscles-and-chemoreflex-sensitivity-in-heart-failure-a-breath-of-fresh-air
#1
EDITORIAL
Richard Severin, Shane A Phillips
No abstract text is available yet for this article.
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28340864/multi-dimensional-scores-to-predict-mortality-in-patients-with-idiopathic-pulmonary-fibrosis-undergoing-lung-transplantation-assessment
#2
Jolene H Fisher, Faris Al-Hejaili, Sonja Kandel, Alim Hirji, Shane Shapera, Marco Mura
BACKGROUND: The heterogeneous progression of idiopathic pulmonary fibrosis (IPF) makes prognostication difficult and contributes to high mortality on the waitlist for lung transplantation (LTx). Multi-dimensional scores (Composite Physiologic index [CPI], [Gender-Age-Physiology [GAP]; RIsk Stratification scorE [RISE]) demonstrated enhanced predictive power towards outcome in IPF. The lung allocation score (LAS) is a multi-dimensional tool commonly used to stratify patients assessed for LTx...
April 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28329546/gardner-diamond-syndrome
#3
Joyce H Park, Sarah Yagerman, Hao Feng, Randie H Kim, Shane A Meehan, Jesse Lewin
Gardner-Diamond syndrome, which also is knownas autoerythrocyte sensitization disorder, is a raresyndrome of inflammatory, edematous papulesthat evolve into painful ecchymoses on the trunkand lower legs after a period of stress with no priorhistory of trauma. This syndrome usually occurs inwomen with a history of psychiatric disorders, themost common one being depression. Although theexact mechanism of injury is not well understood,it is hypothesized that these patients haveautoantibodies to phosphatidylserine, which is aphospholipid membrane component in erythrocytes...
December 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28301752/coded-apertures-in-mass-spectrometry
#4
Jason J Amsden, Michael E Gehm, Zachary E Russell, Evan X Chen, Shane T Di Dona, Scott D Wolter, Ryan M Danell, Gottfried Kibelka, Charles B Parker, Brian R Stoner, David J Brady, Jeffrey T Glass
The use of coded apertures in mass spectrometry can break the trade-off between throughput and resolution that has historically plagued conventional instruments. Despite their very early stage of development, coded apertures have been shown to increase throughput by more than one order of magnitude, with no loss in resolution in a simple 90-degree magnetic sector. This enhanced throughput can increase the signal level with respect to the underlying noise, thereby significantly improving sensitivity to low concentrations of analyte...
March 6, 2017: Annual Review of Analytical Chemistry
https://www.readbyqxmd.com/read/28295278/improving-hospital-performance-rankings-using-discrete-patient-diagnoses-for-risk-adjustment-of-outcomes
#5
Brendan DeCenso, Herbert C Duber, Abraham D Flaxman, Shane M Murphy, Michael Hanlon
OBJECTIVE: To assess the changes in patient outcome prediction and hospital performance ranking when incorporating diagnoses as risk adjusters rather than comorbidity indices. DATA SOURCES: Healthcare Cost and Utilization Project State Inpatient Databases for New York State, 2005-2009. STUDY DESIGN: Conducted tree-based classification for mortality and readmission by incorporating discrete patient diagnoses as predictors, comparing with traditional comorbidity indices such as those used for Centers for Medicare and Medicaid Services (CMS) outcome models...
March 13, 2017: Health Services Research
https://www.readbyqxmd.com/read/28235790/short-term-regular-aerobic-exercise-reduces-oxidative-stress-produced-by-acute-high-intraluminal-pressure-in-the-adipose-microvasculature
#6
Austin T Robinson, Ibra S Fancher, Varadarajan Sudhahar, Jing Tan Bian, Marc Cook, Abeer M Mahmoud, Mohamed Ali, Masuko Ushio-Fukai, Michael D Brown, Tohru Fukai, Shane A Phillips
High blood pressure has been shown to elicit impaired dilation in the vasculature. The purpose of this investigation was to elucidate the mechanisms through which high pressure may elicit vascular dysfunction, and determine the mechanisms through which regular aerobic exercise protects arteries against high pressure. METHODS: Male C57Bl6 mice were subjected to two weeks of voluntary running (~ 6km/day) for comparison to sedentary controls. Hind limb adipose resistance arteries were dissected from mice for measurement of flow-induced dilation (FID; with or without high intraluminal pressure exposure); or protein expression of NADPH oxidase II (NOX II) and superoxide dismutase (SOD)...
February 24, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28203210/auditory-and-visual-electrophysiology-of-deaf-children-with-cochlear-implants-implications-for-cross-modal-plasticity
#7
David P Corina, Shane Blau, Todd LaMarr, Laurel A Lawyer, Sharon Coffey-Corina
Deaf children who receive a cochlear implant early in life and engage in intensive oral/aural therapy often make great strides in spoken language acquisition. However, despite clinicians' best efforts, there is a great deal of variability in language outcomes. One concern is that cortical regions which normally support auditory processing may become reorganized for visual function, leaving fewer available resources for auditory language acquisition. The conditions under which these changes occur are not well understood, but we may begin investigating this phenomenon by looking for interactions between auditory and visual evoked cortical potentials in deaf children...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28186445/subdural-hematoma-as-a-major-determinant-of-short-term-outcomes-in-traumatic-brain-injury
#8
Jonathan J Lee, David J Segar, John F Morrison, William M Mangham, Shane Lee, Wael F Asaad
OBJECTIVE Early radiographic findings in patients with traumatic brain injury (TBI) have been studied in hopes of better predicting injury severity and outcome. However, prior attempts have generally not considered the various types of intracranial hemorrhage in isolation and have typically not excluded patients with potentially confounding extracranial injuries. Therefore, the authors examined the associations of various radiographic findings with short-term outcome to assess the potential utility of these findings in future prognostic models...
February 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28158137/optical-sensor-for-dual-sensing-of-oxygen-and-carbon-dioxide-based-on-sensing-films-coated-on-filter-paper
#9
Cheng-Shane Chu, Jhih-Jheng Syu
An optical sensor for the dual sensing of oxygen (O<sub>2</sub>) and carbon dioxide (CO<sub>2</sub>) based on sensing films coated on filter paper is proposed. Ethyl cellulose (EC) doped with platinum(II) meso-tetrakis(pentafluorophenyl)porphyrin (PtTFPP) and 7-amino-4-trifluoromethyl coumarin serve as the oxygen sensing material and reference blue emission dye for the pH indicator, respectively. The CO<sub>2</sub> sensing layer includes the pH-sensitive fluorescent indicator 1-hydroxy-3,6,8-pyrenetrisulfonic acid trisodium salt immobilized within the EC...
February 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28131548/an-orally-bioavailable-chk1-inhibitor-cct244747-sensitizes-bladder-and-head-and-neck-cancer-cell-lines-to-radiation
#10
Radhika Patel, Holly E Barker, Joan Kyula, Martin McLaughlin, Magnus T Dillon, Ulrike Schick, Hind Hafsi, Alan Thompson, Vincent Khoo, Kevin Harrington, Shane Zaidi
PURPOSE: Chk1 inhibition increases cell sensitivity to both chemotherapy and radiotherapy in several tumour types and is, therefore, a promising anti-cancer approach. Although several Chk1 inhibitors have been developed, their clinical progress has been hampered by low bioavailability and off-target toxicities. MATERIALS AND METHODS: We characterized the radiosensitizing activity of CCT244747, the first orally bioavailable Chk1 inhibitor. We used a panel of bladder and head and neck cancer cell lines and monitored the effect of combining CCT244747 with radiation both in in vitro and in vivo models...
January 25, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28111415/permeation-of-limonene-through-disposable-nitrile-gloves-using-a-dextrous-robot-hand
#11
Sean Banaee, Shane S Que Hee
OBJECTIVES: The purpose of this study was to investigate the permeation of the low-volatile solvent limonene through different disposable, unlined, unsupported, nitrile exam whole gloves (blue, purple, sterling, and lavender, from Kimberly-Clark). METHODS: This study utilized a moving and static dextrous robot hand as part of a novel dynamic permeation system that allowed sampling at specific times. Quantitation of limonene in samples was based on capillary gas chromatography-mass spectrometry and the internal standard method (4-bromophenol)...
January 21, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28111261/sex-differences-in-psychotomimetic-induced-behaviours-in-rats
#12
Andrea Gogos, Snezana Kusljic, Shane J Thwaites, Maarten van den Buuse
Animal model studies using equal numbers of males and females are sparse in psychiatry research. Given the marked sex differences observed in psychiatric disorders, such as schizophrenia, using both males and females in research studies is an important requirement. Thus the aim of this study was to examine sex differences in psychotomimetic-induced behavioural deficits relevant to psychosis. We therefore compared the acute effect of amphetamine or phencyclidine on locomotor activity and prepulse inhibition in adult male and female Sprague-Dawley rats...
January 19, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28081046/evaluation-of-herpes-simplex-virus-type-2-serological-tests-for-use-with-dried-blood-spots-in-kenya
#13
Marcia M Hobbs, Sophie W Mwanyumba, Winnie K Luseno, Shane Hartman, Carolyn T Halpern, Denise D Hallfors, Hyunsan Cho
We evaluated 2 assays to detect antibodies to herpes simplex virus type 2 in dried blood spots prepared from blood specimens submitted to a reference laboratory in Kenya. Dried blood spots did not perform well with the Kalon herpes simplex virus type 2 assay. Focus HerpeSelect 2 was 98.8% sensitive and 98.9% specific with dried blood spots.
February 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28035343/effects-of-different-degrees-of-insulin-resistance-on-endothelial-function-in%C3%A2-obese%C3%A2-adults-undergoing-alternate-day%C3%A2-fasting
#14
Kristin K Hoddy, Surabhi Bhutani, Shane A Phillips, Krista A Varady
BACKGROUND: Obesity can have deleterious effects on insulin sensitivity leading to endothelial dysfunction. Whether alternate day fasting (ADF) can ameliorate insulin sensitivity in a way that improves endothelial function remains unknown. OBJECTIVE: This study examined the impact of ADF on endothelium dependent flow mediated dilation (FMD) in obese subjects with different degrees of insulin resistance. METHODS: Obese non-diabetic adults (n = 54) participated in an 8-week ADF protocol (25% energy intake "fast day", alternated with ad libitum intake "feast day")...
October 27, 2016: Nutr Healthy Aging
https://www.readbyqxmd.com/read/28032265/using-continuous-quantitative-capnography-for-emergency-department-procedural-sedation-a-systematic-review-and-cost-effectiveness-analysis
#15
Nicholas Matthew Mohr, Andrew Stoltze, Azeemuddin Ahmed, Elizabeth Kiscaden, Dan Shane
End-tidal CO2 has been advocated to improve safety of emergency department (ED) procedural sedation by decreasing hypoxia and catastrophic outcomes. This study aimed to estimate the cost-effectiveness of routine use of continuous waveform quantitative end-tidal CO2 monitoring for ED procedural sedation in prevention of catastrophic events. Markov modeling was used to perform cost-effectiveness analysis to estimate societal costs per prevented catastrophic event (death or hypoxic brain injury) during routine ED procedural sedation...
December 28, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27986732/insight-into-the-genome-of-brochothrix-thermosphacta-a-problematic-meat-spoilage-bacterium
#16
Tamsyn Stanborough, Narelle Fegan, Shane M Powell, Mark Tamplin, P Scott Chandry
Brochothrix thermosphacta is a dominant but poorly studied meat spoilage organism. It is a close relative of the foodborne pathogen Listeria monocytogenes, and Brochothrix constitutes the second genus in the Listeriaceae family. Here, the genomes of 12 B. thermosphacta strains were sequenced, assembled into draft genomes, characterized, and compared with the genomes of Brochothrix campestris and L. monocytogenes Phenotypic properties including biogenic amine production and antibiotic and heavy metal susceptibilities were tested...
March 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27923824/human-dendritic-cells-mitigate-nk-cell-dysfunction-mediated-by-nonselective-jak1-2-blockade
#17
Shane A Curran, Justin A Shyer, Erin T St Angelo, Lillian R Talbot, Sneh Sharma, David J Chung, Glenn Heller, Katharine C Hsu, Brian C Betts, James W Young
Janus kinase (JAK) inhibitors have achieved positive responses in myeloproliferative neoplasms, but at the expense of decreased natural killer (NK) cell numbers and compromised function. Selective JAK2 inhibition may also have a role in preventing and treating graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Although JAK inhibitors can impair monocyte-derived dendritic cell (moDC) activation and function and suppress effector T-cell responses, the effects on NK cells and the relevant mechanisms remain undefined...
January 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/27899039/sensitive-monitoring-of-acute-promyelocytic-leukemia-by-pml-rara-dna-q-pcr
#18
Ivar O Kommers, Paul A Bartley, Bradley Budgen, Sue Latham, Ashanka Beligaswatte, Shane G Supple, Alberto Catalano, Harry J Iland, Alexander A Morley, David M Ross
No abstract text is available yet for this article.
November 30, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27868239/co-exposure-to-sunlight-enhances-the-toxicity-of-naturally-weathered-deepwater-horizon-oil-to-early-lifestage-red-drum-sciaenops-ocellatus-and-speckled-seatrout-cynoscion-nebulosus
#19
Matthew Alloy, Thomas Ross Garner, Kristin Bridges, Charles Mansfield, Michael Carney, Heather Forth, Michelle Krasnec, Claire Lay, Ryan Takeshita, Jeffrey Morris, Shane Bonnot, James Oris, Aaron Roberts
The 2010 Deepwater Horizon oil spill resulted in the accidental release of millions of barrels of crude oil into the Gulf of Mexico. Photo-induced toxicity following co-exposure to ultraviolet (UV) radiation is 1 mechanism by which polycyclic aromatic hydrocarbons (PAHs) from oil spills may exert toxicity. Red drum and speckled seatrout are both important fishery resources in the Gulf of Mexico. They spawn near-shore and produce positively buoyant embryos that hatch into larvae in approximately 24 h. The goal of the present study was to determine whether exposure to UV as natural sunlight enhances the toxicity of crude oil to early lifestage red drum and speckled seatrout...
March 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27859528/the-effects-of-pharmaceuticals-on-a-unionid-mussel-lampsilis-siliquoidea-an-examination-of-acute-and-chronic-endpoints-of-toxicity-across-life-stages
#20
Ève A M Gilroy, Patricia L Gillis, Laura E King, Nicholas A Bendo, Joseph Salerno, Marina Giacomin, Shane R de Solla
The toxicity and bioconcentration of three pharmaceuticals (amitriptyline, iopamidol and sertraline) were examined using multiple life stages (larval, juvenile, and adult) of the unionid mussel Lampsilis siliquoidea. The endpoints examined varied with life stage, but included survival, behavior (algal clearance rate, filtering frequency), and oxidative stress. Iopamidol was not toxic at concentrations up to 101 mg/L. Sertraline was the most toxic chemical (LC/EC50 = 0.02-0.04 mg/L), but exposure did not induce oxidative stress...
November 10, 2016: Environmental Toxicology and Chemistry
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