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https://www.readbyqxmd.com/read/27923824/human-dendritic-cells-mitigate-nk-cell-dysfunction-mediated-by-nonselective-jak1-2-blockade
#1
Shane A Curran, Justin A Shyer, Erin T St Angelo, Lillian R Talbot, Sneh Sharma, David J Chung, Glenn Heller, Katharine C Hsu, Brian C Betts, James W Young
Janus kinase (JAK) inhibitors have achieved positive responses in myeloproliferative neoplasms, but at the expense of decreased natural killer (NK) cell numbers and compromised function. Selective JAK2 inhibition may also have a role in preventing and treating graft-vs-host disease after allogeneic hematopoietic stem cell transplantation. Although JAK inhibitors can impair monocyte-derived dendritic cell (moDC) activation and function and suppress effector T-cell responses, the effects on NK cells and the relevant mechanisms remain undefined...
6, 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27899039/sensitive-monitoring-of-acute-promyelocytic-leukemia-by-pml-rara-dna-q-pcr
#2
Ivar O Kommers, Paul A Bartley, Bradley Budgen, Sue Latham, Ashanka Beligaswatte, Shane G Supple, Alberto Catalano, Harry J Iland, Alexander A Morley, David M Ross
No abstract text is available yet for this article.
November 30, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27868239/co-exposure-to-sunlight-enhances-the-toxicity-of-naturally-weathered-deepwater-horizon-oil-to-early-lifestage-red-drum-sciaenops-ocellatus-and-speckled-seatrout-cynoscion-nebulosus
#3
Matthew Alloy, Thomas Ross Garner, Kristin Bridges, Charles Mansfield, Michael Carney, Heather Forth, Michelle Krasnec, Claire Lay, Ryan Takeshita, Jeffrey Morris, Shane Bonnot, James Oris, Aaron Roberts
The 2010 Deepwater Horizon oil spill resulted in the accidental release of millions of barrels of crude oil into the Gulf of Mexico. Photo-induced toxicity following co-exposure to ultraviolet (UV) radiation is 1 mechanism by which polycyclic aromatic hydrocarbons (PAHs) from oil spills may exert toxicity. Red drum and speckled seatrout are both important fishery resources in the Gulf of Mexico. They spawn near-shore and produce positively buoyant embryos that hatch into larvae in approximately 24 h. The goal of the present study was to determine whether exposure to UV as natural sunlight enhances the toxicity of crude oil to early lifestage red drum and speckled seatrout...
November 21, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27859528/the-effects-of-pharmaceuticals-on-a-unionid-mussel-lampsilis-siliquoidea-an-examination-of-acute-and-chronic-endpoints-of-toxicity-across-life-stages
#4
Ève A M Gilroy, Patricia L Gillis, Laura E King, Nicholas A Bendo, Joseph Salerno, Marina Giacomin, Shane R de Solla
The toxicity and bioconcentration of three pharmaceuticals (amitriptyline, iopamidol and sertraline) were examined using multiple life stages (larval, juvenile, and adult) of the unionid mussel Lampsilis siliquoidea. The endpoints examined varied with life stage, but included survival, behavior (algal clearance rate, filtering frequency), and oxidative stress. Iopamidol was not toxic at concentrations up to 101 mg/L. Sertraline was the most toxic chemical (LC/EC50 = 0.02-0.04 mg/L), but exposure did not induce oxidative stress...
November 10, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27859264/inwardly-rectifying-k-channels-are-major-contributors-to-flow-induced-vasodilation-in-resistance-arteries
#5
Sang Joon Ahn, Ibra S Fancher, Jing-Tan Bian, Chong Xu Zhang, Sarah Schwab, Robert Gaffin, Shane A Phillips, Irena Levitan
AIMS: Inwardly rectifying K(+) (Kir) channels are known to be sensitive to flow, but their role in flow-induced endothelial responses is not known. The goal of this study is to establish the role of Kir channels in flow-induced vasodilation and to provide first insights into the mechanisms responsible for Kir signaling in this process. METHODS AND RESULTS: First, we establish that primary endothelial cells isolated from murine mesenteric arteries express functional Kir2...
November 17, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27806464/determination-of-geohelminthiasis-and-its-association-with-allergic-sensitization-among-selected-children-in-batangas-philippines
#6
Carina R Magbojos, Shereen O Chua, Charlene R Alegria, Faustina C Macalalad, Anne Camille R Malayba, Alyssa Andrea D Mandigma, Oliver Shane R Dumaoal
Several studies have explored the cross-reactivity between geohelminthiasis and allergy which share the same immune response in humans by triggering the increase in serum IgE level. Yet, the role of soil-transmitted intestinal parasitism as a protective or contributing factor for allergy remains inconclusive. In this study, the association of geohelminthiasis with allergic sensitization was investigated in a cohort of 50 children aged 5 to 12 years old residing in the areas of Batangas, Philippines where parasitism is prevalent...
June 30, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27759703/p53-is-a-helpful-marker-in-distinguishing-langerhans-cell-histiocytosis-from-langerhans-cell-hyperplasia
#7
Shane A Grace, Angela M Sutton, Eric S Armbrecht, Claudia I Vidal, Ilana S Rosman, Maria Y Hurley
Langerhans cell histiocytosis (LCH) is a proliferative disorder of Langerhans cells that can be challenging to distinguish histologically from Langerhans cell (LC) hyperplasia, seen in a variety of inflammatory dermatoses. Lesional cells in both entities demonstrate positive staining for CD1a and S100. Previous studies have demonstrated positive staining of fascin, CD31, and p53 in cases of LCH, but currently, no studies have compared the staining profiles of these markers between LCH and LC hyperplasia. The authors compared immunohistochemical staining profiles of LCH (n = 15) and various inflammatory dermatoses with LC hyperplasia (n = 15) using fascin, CD31, and p53...
October 18, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27643875/enhancement-of-radiation-response-in-breast-cancer-stem-cells-by-inhibition-of-thioredoxin-and-glutathione-dependent-metabolism
#8
Samuel N Rodman, Jacquelyn M Spence, Tyler J Ronnfeldt, Yueming Zhu, Shane R Solst, Rebecca A O'Neill, Bryan G Allen, Xiangming Guan, Douglas R Spitz, Melissa A Fath
The goal of this study was to determine if depletion of glutathione (GSH) and inhibition of thioredoxin (Trx) reductase (TrxR) activity could enhance radiation responses in human breast cancer stem cells by a mechanism involving thiol-dependent oxidative stress. The following were used to inhibit GSH and Trx metabolism: buthionine sulfoximine (BSO), a GSH synthesis inhibitor; sulfasalazine (SSZ), an inhibitor of xc(-) cysteine/glutamate antiporter; auranofin (Au), a thioredoxin reductase inhibitor; or 2-AAPA, a GSH-reductase inhibitor...
October 2016: Radiation Research
https://www.readbyqxmd.com/read/27629096/subarachnoid-hemorrhage-admissions-retrospectively-identified-using-a-prediction-model
#9
Shane W English, Lauralyn McIntyre, Dean Fergusson, Alexis Turgeon, Marlise P Dos Santos, Cheemun Lum, Michaël Chassé, John Sinclair, Alan Forster, Carl van Walraven
OBJECTIVE: To create an accurate prediction model using variables collected in widely available health administrative data records to identify hospitalizations for primary subarachnoid hemorrhage (SAH). METHODS: A previously established complete cohort of consecutive primary SAH patients was combined with a random sample of control hospitalizations. Chi-square recursive partitioning was used to derive and internally validate a model to predict the probability that a patient had primary SAH (due to aneurysm or arteriovenous malformation) using health administrative data...
October 11, 2016: Neurology
https://www.readbyqxmd.com/read/27623385/the-association-between-dry-needling-induced-twitch-response-and-change-in-pain-and-muscle-function-in-patients-with-low-back-pain-a-quasi-experimental-study
#10
Shane L Koppenhaver, Michael J Walker, Charles Rettig, Joel Davis, Chenae Nelson, Jonathan Su, Cesar Fernández-de-Las-Peñas, Jeffrey J Hebert
OBJECTIVE: To investigate the relationship between dry needling-induced twitch response and change in pain, disability, nociceptive sensitivity, and lumbar multifidus muscle function, in patients with low back pain (LBP). DESIGN: Quasi-experimental study. SETTING: Department of Defense Academic Institution. PARTICIPANTS: Sixty-six patients with mechanical LBP (38 men, 28 women, age: 41.3 [9.2] years). INTERVENTIONS: Dry needling treatment to the lumbar multifidus muscles between L3 and L5 bilaterally...
May 20, 2016: Physiotherapy
https://www.readbyqxmd.com/read/27603676/use-of-digitally-stained-multimodal-confocal-mosaic-images-to-screen-for-nonmelanoma-skin-cancer
#11
Euphemia W Mu, Jesse M Lewin, Mary L Stevenson, Shane A Meehan, John A Carucci, Daniel S Gareau
Importance: Confocal microscopy has the potential to provide rapid bedside pathologic analysis, but clinical adoption has been limited in part by the need for physician retraining to interpret grayscale images. Digitally stained confocal mosaics (DSCMs) mimic the colors of routine histologic specimens and may increase adaptability of this technology. Objective: To evaluate the accuracy and precision of 3 physicians using DSCMs before and after training to detect basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in Mohs micrographic surgery fresh-tissue specimens...
September 7, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27593468/gravimetric-phenotyping-of-whole-plant-transpiration-responses-to-atmospheric-vapour-pressure-deficit-identifies-genotypic-variation-in-water-use-efficiency
#12
Annette C Ryan, Ian C Dodd, Shane A Rothwell, Ros Jones, Francois Tardieu, Xavier Draye, William J Davies
There is increasing interest in rapidly identifying genotypes with improved water use efficiency, exemplified by the development of whole plant phenotyping platforms that automatically measure plant growth and water use. Transpirational responses to atmospheric vapour pressure deficit (VPD) and whole plant water use efficiency (WUE, defined as the accumulation of above ground biomass per unit of water used) were measured in 100 maize (Zea mays L.) genotypes. Using a glasshouse based phenotyping platform with naturally varying VPD (1...
October 2016: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/27590593/drug-eluting-biodegradable-ureteral-stent-new-approach-for-urothelial-tumors-of-upper-urinary-tract-cancer
#13
Alexandre A Barros, Shane Browne, Carlos Oliveira, Estevão Lima, Ana Rita C Duarte, Kevin E Healy, Rui L Reis
Upper urinary tract urothelial carcinoma (UTUC) accounts for 5-10% of urothelial carcinomas and is a disease that has not been widely studied as carcinoma of the bladder. To avoid the problems of conventional therapies, such as the need for frequent drug instillation due to poor drug retention, we developed a biodegradable ureteral stent (BUS) impregnated by supercritical fluid CO2 (scCO2) with the most commonly used anti-cancer drugs, namely paclitaxel, epirubicin, doxorubicin, and gemcitabine. The release kinetics of anti-cancer therapeutics from drug-eluting stents was measured in artificial urine solution (AUS)...
August 31, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27586588/the-characterization-of-an-intestine-like-genomic-signature-maintained-during-barrett-s-associated-adenocarcinogenesis-reveals-an-nr5a2-mediated-promotion-of-cancer-cell-survival
#14
Shane P Duggan, Fiona M Behan, Murat Kirca, Abdul Zaheer, Sarah A McGarrigle, John V Reynolds, Gisela M F Vaz, Mathias O Senge, Dermot Kelleher
Barrett's oesophagus (BO), an intestinal-type metaplasia (IM), typically arising in conjunction with gastro-oesophageal reflux disease, is a prominent risk factor for the development of oesophageal adenocarcinoma (OAC). The molecular similarities between IM and normal intestinal tissues are ill-defined. Consequently, the contribution of intestine-enriched factors expressed within BO to oncogenesis is unclear. Herein, using transcriptomics we define the intestine-enriched genes expressed in meta-profiles of BO and OAC...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27584137/step-activity-and-6-minute-walk-test-outcomes-when-wearing-low-activity-or-high-activity-prosthetic-feet
#15
Shane R Wurdeman, Kendra K Schmid, Sara A Myers, Adam L Jacobsen, Nicholas Stergiou
OBJECTIVE: To determine changes in average daily step count (ADSC) and 6-minute walk test (6MWT) due to use of low-activity feet (LA) and high-activity energy-storage-and-return (ESAR) feet, and examine the sensitivity of these measures to properly classify different prosthetic feet. DESIGN: Individuals with transtibial amputations (n = 28) participated in a 6-week, randomized crossover study. During separate 3-week periods, participants wore either a LA foot (eg, solid-ankle-cushioned-heel) or an ESAR foot...
August 31, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27565820/a-comparison-of-pcr-assays-for-beak-and-feather-disease-virus-and-high-resolution-melt-hrm-curve-analysis-of-replicase-associated-protein-and-capsid-genes
#16
Shubhagata Das, Subir Sarker, Seyed Ali Ghorashi, Jade K Forwood, Shane R Raidal
Beak and feather disease virus (BFDV) threatens a wide range of endangered psittacine birds worldwide. In this study, we assessed a novel PCR assay and genetic screening method using high-resolution melt (HRM) curve analysis for BFDV targeting the capsid (Cap) gene (HRM-Cap) alongside conventional PCR detection as well as a PCR method that targets a much smaller fragment of the virus genome in the replicase initiator protein (Rep) gene (HRM-Rep). Limits of detection, sensitivity, specificity and discriminatory power for differentiating BFDV sequences were compared...
November 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27557043/process-relevant-concentrations-of-the-leachable-bdtbpp-impact-negatively-on-cho-cell-production-characteristics
#17
Paul S Kelly, Shane McSweeney, Orla Coleman, Sara Carillo, Michael Henry, Deepak Chandran, Andrew Kellett, Jonathan Bones, Martin Clynes, Paula Meleady, Niall Barron
The biopharmaceutical industry has invested considerably in the implementation of single-use disposable bioreactors in place of or in addition to their stainless steel counterparts. This new wave of construction materials for disposable bioprocess containers encompass a plethora of uncharacterised secondary compounds that, when in contact with the culture media, can leach, contaminating the bioprocess. One such cytotoxic leachable already receiving attention is bis(2,4-di-tert-butylphenyl)-phosphate (bDtBPP), a breakdown product of the secondary antioxidant Irgafos 168 in polyethylene-film based bags...
August 24, 2016: Biotechnology Progress
https://www.readbyqxmd.com/read/27531218/caloric-restriction-selectively-reduces-the-gabaergic-phenotype-of-mouse-hypothalamic-proopiomelanocortin-neurons
#18
Brooke C Jarvie, Connie M King, Alexander R Hughes, Matthew S Dicken, Christina S Dennison, Shane T Hentges
KEY POINTS: Hypothalamic proopiomelanocortin (POMC) neurons release peptide products that potently inhibit food intake and reduce body weight. These neurons also release the amino acid transmitter GABA, which can inhibit downstream neurons. Although the release of peptide transmitters from POMC neurons is regulated by energy state, whether similar regulation of GABA release might occur had not been examined. The present results show that the GABAergic phenotype of POMC neurons is decreased selectively by caloric deficit and not altered by high-fat diet or stress...
August 17, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27497188/effects-of-dry-needling-to-the-symptomatic-versus-control-shoulder-in-patients-with-unilateral-subacromial-pain-syndrome
#19
Shane Koppenhaver, Robin Embry, John Ciccarello, Justin Waltrip, Rachel Pike, Michael Walker, Cesar Fernández-de-Las-Peñas, Theodore Croy, Timothy Flynn
BACKGROUND: Initial reports suggest that treating myofascial trigger points in the infraspinatus with dry needling may be effective in treating patients with shoulder pain. However, to date, high quality clinical trials and thorough knowledge of the physiologic mechanisms involved is lacking. OBJECTIVES: To examine the effect of dry needling to the infraspinatus muscle on muscle function, nociceptive sensitivity, and shoulder range of motion (ROM) in the symptomatic and asymptomatic shoulders of individuals with unilateral subacromial pain syndrome...
December 2016: Manual Therapy
https://www.readbyqxmd.com/read/27489009/serum-immune-system-biomarkers-neopterin-and-interleukin-10-are-strongly-related-to-tryptophan-metabolism-in-healthy-young-adults
#20
Oana M Deac, James L Mills, Clair M Gardiner, Barry Shane, Louise Quinn, Øivind Midttun, Adrian McCann, Klaus Meyer, Per M Ueland, Ruzong Fan, Zhaohui Lu, Lawrence C Brody, Anne M Molloy
BACKGROUND: Changes in tryptophan metabolism through the vitamin B-6-dependent kynurenine pathway have been linked to activation of the immune system. OBJECTIVE: We hypothesized that blood concentrations of tryptophan and its catabolites were associated with biomarkers relevant to inflammatory processes in healthy noninflamed subjects. METHODS: Healthy young adults (n = 737) aged 18-28 y without any known diseases or clinical evidence of inflammation provided blood samples for analysis of serum tryptophan/kynurenine metabolites, neopterin, C-reactive protein (CRP), and plasma pyridoxal 5'-phosphate (PLP) with LC-tandem mass spectrometry methodologies...
September 2016: Journal of Nutrition
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