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https://www.readbyqxmd.com/read/28203210/auditory-and-visual-electrophysiology-of-deaf-children-with-cochlear-implants-implications-for-cross-modal-plasticity
#1
David P Corina, Shane Blau, Todd LaMarr, Laurel A Lawyer, Sharon Coffey-Corina
Deaf children who receive a cochlear implant early in life and engage in intensive oral/aural therapy often make great strides in spoken language acquisition. However, despite clinicians' best efforts, there is a great deal of variability in language outcomes. One concern is that cortical regions which normally support auditory processing may become reorganized for visual function, leaving fewer available resources for auditory language acquisition. The conditions under which these changes occur are not well understood, but we may begin investigating this phenomenon by looking for interactions between auditory and visual evoked cortical potentials in deaf children...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28186445/subdural-hematoma-as-a-major-determinant-of-short-term-outcomes-in-traumatic-brain-injury
#2
Jonathan J Lee, David J Segar, John F Morrison, William M Mangham, Shane Lee, Wael F Asaad
OBJECTIVE Early radiographic findings in patients with traumatic brain injury (TBI) have been studied in hopes of better predicting injury severity and outcome. However, prior attempts have generally not considered the various types of intracranial hemorrhage in isolation and have typically not excluded patients with potentially confounding extracranial injuries. Therefore, the authors examined the associations of various radiographic findings with short-term outcome to assess the potential utility of these findings in future prognostic models...
February 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28158137/optical-sensor-for-dual-sensing-of-oxygen-and-carbon-dioxide-based-on-sensing-films-coated-on-filter-paper
#3
Cheng-Shane Chu, Jhih-Jheng Syu
An optical sensor for the dual sensing of oxygen (O<sub>2</sub>) and carbon dioxide (CO<sub>2</sub>) based on sensing films coated on filter paper is proposed. Ethyl cellulose (EC) doped with platinum(II) meso-tetrakis(pentafluorophenyl)porphyrin (PtTFPP) and 7-amino-4-trifluoromethyl coumarin serve as the oxygen sensing material and reference blue emission dye for the pH indicator, respectively. The CO<sub>2</sub> sensing layer includes the pH-sensitive fluorescent indicator 1-hydroxy-3,6,8-pyrenetrisulfonic acid trisodium salt immobilized within the EC...
February 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28131548/an-orally-bioavailable-chk1-inhibitor-cct244747-sensitizes-bladder-and-head-and-neck-cancer-cell-lines-to-radiation
#4
Radhika Patel, Holly E Barker, Joan Kyula, Martin McLaughlin, Magnus T Dillon, Ulrike Schick, Hind Hafsi, Alan Thompson, Vincent Khoo, Kevin Harrington, Shane Zaidi
PURPOSE: Chk1 inhibition increases cell sensitivity to both chemotherapy and radiotherapy in several tumour types and is, therefore, a promising anti-cancer approach. Although several Chk1 inhibitors have been developed, their clinical progress has been hampered by low bioavailability and off-target toxicities. MATERIALS AND METHODS: We characterized the radiosensitizing activity of CCT244747, the first orally bioavailable Chk1 inhibitor. We used a panel of bladder and head and neck cancer cell lines and monitored the effect of combining CCT244747 with radiation both in in vitro and in vivo models...
January 25, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28111415/permeation-of-limonene-through-disposable-nitrile-gloves-using-a-dextrous-robot-hand
#5
Sean Banaee, Shane S Que Hee
OBJECTIVES: The purpose of this study was to investigate the permeation of the low-volatile solvent limonene through different disposable, unlined, unsupported, nitrile exam whole gloves (blue, purple, sterling, and lavender, from Kimberly-Clark). METHODS: This study utilized a moving and static dextrous robot hand as part of a novel dynamic permeation system that allowed sampling at specific times. Quantitation of limonene in samples was based on capillary gas chromatography-mass spectrometry and the internal standard method (4-bromophenol)...
January 21, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28111261/sex-differences-in-psychotomimetic-induced-behaviours-in-rats
#6
Andrea Gogos, Snezana Kusljic, Shane J Thwaites, Maarten van den Buuse
Animal model studies using equal numbers of males and females are sparse in psychiatry research. Given the marked sex differences observed in psychiatric disorders, such as schizophrenia, using both males and females in research studies is an important requirement. Thus the aim of this study was to examine sex differences in psychotomimetic-induced behavioural deficits relevant to psychosis. We therefore compared the acute effect of amphetamine or phencyclidine on locomotor activity and prepulse inhibition in adult male and female Sprague-Dawley rats...
January 19, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28081046/evaluation-of-herpes-simplex-virus-type-2-serological-tests-for-use-with-dried-blood-spots-in-kenya
#7
Marcia M Hobbs, Sophie W Mwanyumba, Winnie K Luseno, Shane Hartman, Carolyn T Halpern, Denise D Hallfors, Hyunsan Cho
We evaluated 2 assays to detect antibodies to herpes simplex virus type 2 in dried blood spots prepared from blood specimens submitted to a reference laboratory in Kenya. Dried blood spots did not perform well with the Kalon herpes simplex virus type 2 assay. Focus HerpeSelect 2 was 98.8% sensitive and 98.9% specific with dried blood spots.
February 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28035343/effects-of-different-degrees-of-insulin-resistance-on-endothelial-function-in%C3%A2-obese%C3%A2-adults-undergoing-alternate-day%C3%A2-fasting
#8
Kristin K Hoddy, Surabhi Bhutani, Shane A Phillips, Krista A Varady
BACKGROUND: Obesity can have deleterious effects on insulin sensitivity leading to endothelial dysfunction. Whether alternate day fasting (ADF) can ameliorate insulin sensitivity in a way that improves endothelial function remains unknown. OBJECTIVE: This study examined the impact of ADF on endothelium dependent flow mediated dilation (FMD) in obese subjects with different degrees of insulin resistance. METHODS: Obese non-diabetic adults (n = 54) participated in an 8-week ADF protocol (25% energy intake "fast day", alternated with ad libitum intake "feast day")...
October 27, 2016: Nutr Healthy Aging
https://www.readbyqxmd.com/read/28032265/using-continuous-quantitative-capnography-for-emergency-department-procedural-sedation-a-systematic-review-and-cost-effectiveness-analysis
#9
Nicholas Matthew Mohr, Andrew Stoltze, Azeemuddin Ahmed, Elizabeth Kiscaden, Dan Shane
End-tidal CO2 has been advocated to improve safety of emergency department (ED) procedural sedation by decreasing hypoxia and catastrophic outcomes. This study aimed to estimate the cost-effectiveness of routine use of continuous waveform quantitative end-tidal CO2 monitoring for ED procedural sedation in prevention of catastrophic events. Markov modeling was used to perform cost-effectiveness analysis to estimate societal costs per prevented catastrophic event (death or hypoxic brain injury) during routine ED procedural sedation...
December 28, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27986732/comparative-genomic-study-of-the-meat-spoilage-organism-brochothrix-thermosphacta
#10
Tamsyn Stanborough, Narelle Fegan, Shane M Powell, Mark Tamplin, P Scott Chandry
: Brochothrix thermosphacta is a dominant, but poorly studied meat spoilage organism. It is a close relative of the foodborne pathogen Listeria monocytogenes and constitutes the second genera in the Listeriaceae family. Here, the genomes of 12 B. thermosphacta strains were sequenced, assembled into draft genomes, characterized and compared with the genomes of Brochothrix campestris and L. monocytogenes Phenotypic properties including biogenic amine production, and antibiotic and heavy metal susceptibility were tested...
December 16, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27923824/human-dendritic-cells-mitigate-nk-cell-dysfunction-mediated-by-nonselective-jak1-2-blockade
#11
Shane A Curran, Justin A Shyer, Erin T St Angelo, Lillian R Talbot, Sneh Sharma, David J Chung, Glenn Heller, Katharine C Hsu, Brian C Betts, James W Young
Janus kinase (JAK) inhibitors have achieved positive responses in myeloproliferative neoplasms, but at the expense of decreased natural killer (NK) cell numbers and compromised function. Selective JAK2 inhibition may also have a role in preventing and treating graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Although JAK inhibitors can impair monocyte-derived dendritic cell (moDC) activation and function and suppress effector T-cell responses, the effects on NK cells and the relevant mechanisms remain undefined...
January 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/27899039/sensitive-monitoring-of-acute-promyelocytic-leukemia-by-pml-rara-dna-q-pcr
#12
Ivar O Kommers, Paul A Bartley, Bradley Budgen, Sue Latham, Ashanka Beligaswatte, Shane G Supple, Alberto Catalano, Harry J Iland, Alexander A Morley, David M Ross
No abstract text is available yet for this article.
November 30, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27868239/co-exposure-to-sunlight-enhances-the-toxicity-of-naturally-weathered-deepwater-horizon-oil-to-early-lifestage-red-drum-sciaenops-ocellatus-and-speckled-seatrout-cynoscion-nebulosus
#13
Matthew Alloy, Thomas Ross Garner, Kristin Bridges, Charles Mansfield, Michael Carney, Heather Forth, Michelle Krasnec, Claire Lay, Ryan Takeshita, Jeffrey Morris, Shane Bonnot, James Oris, Aaron Roberts
The 2010 Deepwater Horizon oil spill resulted in the accidental release of millions of barrels of crude oil into the Gulf of Mexico. Photo-induced toxicity following co-exposure to ultraviolet (UV) radiation is 1 mechanism by which polycyclic aromatic hydrocarbons (PAHs) from oil spills may exert toxicity. Red drum and speckled seatrout are both important fishery resources in the Gulf of Mexico. They spawn near-shore and produce positively buoyant embryos that hatch into larvae in approximately 24 h. The goal of the present study was to determine whether exposure to UV as natural sunlight enhances the toxicity of crude oil to early lifestage red drum and speckled seatrout...
November 21, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27859528/the-effects-of-pharmaceuticals-on-a-unionid-mussel-lampsilis-siliquoidea-an-examination-of-acute-and-chronic-endpoints-of-toxicity-across-life-stages
#14
Ève A M Gilroy, Patricia L Gillis, Laura E King, Nicholas A Bendo, Joseph Salerno, Marina Giacomin, Shane R de Solla
The toxicity and bioconcentration of three pharmaceuticals (amitriptyline, iopamidol and sertraline) were examined using multiple life stages (larval, juvenile, and adult) of the unionid mussel Lampsilis siliquoidea. The endpoints examined varied with life stage, but included survival, behavior (algal clearance rate, filtering frequency), and oxidative stress. Iopamidol was not toxic at concentrations up to 101 mg/L. Sertraline was the most toxic chemical (LC/EC50 = 0.02-0.04 mg/L), but exposure did not induce oxidative stress...
November 10, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27859264/inwardly-rectifying-k-channels-are-major-contributors-to-flow-induced-vasodilatation-in-resistance-arteries
#15
Sang Joon Ahn, Ibra S Fancher, Jing-Tan Bian, Chong Xu Zhang, Sarah Schwab, Robert Gaffin, Shane A Phillips, Irena Levitan
KEY POINTS: Endothelial inwardly rectifying K(+) (Kir2.1) channels regulate flow-induced vasodilatation via nitric oxide (NO) in mouse mesenteric resistance arteries. Deficiency of Kir2.1 channels results in elevated blood pressure and increased vascular resistance. Flow-induced vasodilatation in human resistance arteries is also regulated by inwardly rectifying K(+) channels. This study presents the first direct evidence that Kir channels play a critical role in physiological endothelial responses to flow...
November 17, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27806464/determination-of-geohelminthiasis-and-its-association-with-allergic-sensitization-among-selected-children-in-batangas-philippines
#16
Carina R Magbojos, Shereen O Chua, Charlene R Alegria, Faustina C Macalalad, Anne Camille R Malayba, Alyssa Andrea D Mandigma, Oliver Shane R Dumaoal
Several studies have explored the cross-reactivity between geohelminthiasis and allergy which share the same immune response in humans by triggering the increase in serum IgE level. Yet, the role of soil-transmitted intestinal parasitism as a protective or contributing factor for allergy remains inconclusive. In this study, the association of geohelminthiasis with allergic sensitization was investigated in a cohort of 50 children aged 5 to 12 years old residing in the areas of Batangas, Philippines where parasitism is prevalent...
June 30, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27759703/p53-is-a-helpful-marker-in-distinguishing-langerhans-cell-histiocytosis-from-langerhans-cell-hyperplasia
#17
Shane A Grace, Angela M Sutton, Eric S Armbrecht, Claudia I Vidal, Ilana S Rosman, Maria Y Hurley
Langerhans cell histiocytosis (LCH) is a proliferative disorder of Langerhans cells that can be challenging to distinguish histologically from Langerhans cell (LC) hyperplasia, seen in a variety of inflammatory dermatoses. Lesional cells in both entities demonstrate positive staining for CD1a and S100. Previous studies have demonstrated positive staining of fascin, CD31, and p53 in cases of LCH, but currently, no studies have compared the staining profiles of these markers between LCH and LC hyperplasia. The authors compared immunohistochemical staining profiles of LCH (n = 15) and various inflammatory dermatoses with LC hyperplasia (n = 15) using fascin, CD31, and p53...
October 18, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27643875/enhancement-of-radiation-response-in-breast-cancer-stem-cells-by-inhibition-of-thioredoxin-and-glutathione-dependent-metabolism
#18
Samuel N Rodman, Jacquelyn M Spence, Tyler J Ronnfeldt, Yueming Zhu, Shane R Solst, Rebecca A O'Neill, Bryan G Allen, Xiangming Guan, Douglas R Spitz, Melissa A Fath
The goal of this study was to determine if depletion of glutathione (GSH) and inhibition of thioredoxin (Trx) reductase (TrxR) activity could enhance radiation responses in human breast cancer stem cells by a mechanism involving thiol-dependent oxidative stress. The following were used to inhibit GSH and Trx metabolism: buthionine sulfoximine (BSO), a GSH synthesis inhibitor; sulfasalazine (SSZ), an inhibitor of xc(-) cysteine/glutamate antiporter; auranofin (Au), a thioredoxin reductase inhibitor; or 2-AAPA, a GSH-reductase inhibitor...
October 2016: Radiation Research
https://www.readbyqxmd.com/read/27629096/subarachnoid-hemorrhage-admissions-retrospectively-identified-using-a-prediction-model
#19
Shane W English, Lauralyn McIntyre, Dean Fergusson, Alexis Turgeon, Marlise P Dos Santos, Cheemun Lum, Michaël Chassé, John Sinclair, Alan Forster, Carl van Walraven
OBJECTIVE: To create an accurate prediction model using variables collected in widely available health administrative data records to identify hospitalizations for primary subarachnoid hemorrhage (SAH). METHODS: A previously established complete cohort of consecutive primary SAH patients was combined with a random sample of control hospitalizations. Chi-square recursive partitioning was used to derive and internally validate a model to predict the probability that a patient had primary SAH (due to aneurysm or arteriovenous malformation) using health administrative data...
October 11, 2016: Neurology
https://www.readbyqxmd.com/read/27623385/the-association-between-dry-needling-induced-twitch-response-and-change-in-pain-and-muscle-function-in-patients-with-low-back-pain-a-quasi-experimental-study
#20
Shane L Koppenhaver, Michael J Walker, Charles Rettig, Joel Davis, Chenae Nelson, Jonathan Su, Cesar Fernández-de-Las-Peñas, Jeffrey J Hebert
OBJECTIVE: To investigate the relationship between dry needling-induced twitch response and change in pain, disability, nociceptive sensitivity, and lumbar multifidus muscle function, in patients with low back pain (LBP). DESIGN: Quasi-experimental study. SETTING: Department of Defense Academic Institution. PARTICIPANTS: Sixty-six patients with mechanical LBP (38 men, 28 women, age: 41.3 [9.2] years). INTERVENTIONS: Dry needling treatment to the lumbar multifidus muscles between L3 and L5 bilaterally...
May 20, 2016: Physiotherapy
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