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Adrienne J Bartlett, Amanda M Hedges, Kyna D Intini, Lisa R Brown, France J Maisonneuve, Stacey A Robinson, Patricia L Gillis, Shane R de Solla
Neonicotinoid insecticides are environmentally persistent and highly water-soluble, and thus are prone to leaching into surface waters where they may negatively affect non-target aquatic insects. Most of the research to date has focused on imidacloprid, and few data are available regarding the effects of other neonicotinoids or their proposed replacements (butenolide insecticides). The objective of this study was to assess the toxicity of six neonicotinoids (imidacloprid, thiamethoxam, acetamiprid, clothianidin, thiacloprid, and dinotefuran) and one butenolide (flupyradifurone) to Hexagenia spp...
March 12, 2018: Environmental Pollution
Richard C Mather, Shane J Nho, Andrew Federer, Berna Demiralp, Jennifer Nguyen, Asha Saavoss, Michael J Salata, Marc J Philippon, Asheesh Bedi, Christopher M Larson, J W Thomas Byrd, Lane Koenig
BACKGROUND: The diagnosis and treatment of femoroacetabular impingement (FAI) have increased steadily within the past decade, and research indicates clinically significant improvements after treatment of FAI with hip arthroscopy. PURPOSE: This study examined the societal and economic impact of hip arthroscopy by high-volume surgeons for patients with FAI syndrome aged <50 years with noncontroversial diagnosis and indications for surgery. STUDY DESIGN: Economic and decision analysis; Level of evidence, 2...
March 1, 2018: American Journal of Sports Medicine
Shelley Macaulay, Martha Ngobeni, David B Dunger, Shane A Norris
AIMS: This study aimed to determine the prevalence of GDM amongst black South African women, describe GDM-associated risk factors and clinical management, and evaluate the efficacy of the fasting plasma glucose reading in diagnosing GDM. METHODS: A cross-sectional screening study was performed. Pregnant women were recruited from the Chris Hani Baragwanath Academic Hospital in Johannesburg. A total of 1906 women underwent a two-hour 75 g oral glucose tolerance test at 24-28 weeks gestation...
March 8, 2018: Diabetes Research and Clinical Practice
Michael Gold, Anneke Andriessen, Alexandros Bader, Red Alinsod, Elizabeth Shane French, Nathan Guerette, Yegor Kolodchenko, Michael Krychman, Susan Murrmann, Julene Samuels
INTRODUCTION: The use of energy-based devices for the treatment of vaginal laxity, orgasmic dysfunction, and stress incontinence, such as minimally ablative fractional laser and radiofrequency, is gaining momentum. This review aims to answer clinical questions on the application of energy-based devices for feminine genital rejuvenation. METHODS: The target group includes physicians involved in esthetic medicine and feminine genital rejuvenation. A literature review was conducted on technologies in use for feminine rejuvenation to explore their safety, efficacy, tolerability, patient satisfaction, and clinical usability...
March 10, 2018: Journal of Cosmetic Dermatology
Katherine L Brown, Deborah A Ridout, Christina Pagel, Monica Lakhanpaul, Suzan Kakat, Victoria Banks, Rodney Franklin, Thomas Witter, Rhian Lakhani, Shane Tibby, David Anderson, Victor Tsang, Aparna U Hoskote, Jo Wray
Introduction The objective of this study was to prospectively validate the "Brief Developmental Assessment", which is a new early recognition tool for neurodevelopmental abnormalities in children with heart disease that was developed for use by cardiac teams. METHODS: This was a prospective validation study among a representative sample of 960 pre-school children with heart disease from three United Kingdom tertiary cardiac centres who were analysed grouped into five separate age bands...
April 2018: Cardiology in the Young
Alan Zhan, Taylor K Fryett, Shane Colburn, Arka Majumdar
Arrays of wavelength scale scatterers are a promising platform for designing optical elements with a compact footprint. The large number of degrees of freedom in this system allows for unique and plentiful functionalities. However, the many variables also create a complex design problem. While intuitive forward design methods work for simple optical elements, they often fail to produce complicated elements, especially those involving multiple elements. We present an inverse design methodology for large arrays of wavelength scale spheres based on both adjoint optimization or sensitivity analysis and generalized multi-sphere Mie theory as a solution to the design problem...
February 20, 2018: Applied Optics
Euphemia W Mu, Nicola A Quatrano, Sarah E Yagerman, Desiree Ratner, Shane A Meehan
BACKGROUND: Melanocytic immunostains can assist in margin evaluation of melanoma in situ (MIS) excisions; however, their accuracy and reliability relative to hematoxylin & eosin (H&E) is yet to be determined. OBJECTIVE: The objective of this study was to evaluate the sensitivity, specificity, and concordance of 4 melanocyte-specific immunostains for diagnosing MIS occurring on chronically sun-damaged skin. MATERIALS AND METHODS: Serial permanent sections from representative areas of negative margin and residual tumor were stained using H&E, MITF, MART-1, SOX10, and R21 and examined in a blinded fashion...
February 6, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Jason M Glanz, Komal J Narwaney, Shane R Mueller, Edward M Gardner, Susan L Calcaterra, Stanley Xu, Kristin Breslin, Ingrid A Binswanger
BACKGROUND: Naloxone is a life-saving opioid antagonist. Chronic pain guidelines recommend that physicians co-prescribe naloxone to patients at high risk for opioid overdose. However, clinical tools to efficiently identify patients who could benefit from naloxone are lacking. OBJECTIVE: To develop and validate an overdose predictive model which could be used in primary care settings to assess the need for naloxone. DESIGN: Retrospective cohort...
January 29, 2018: Journal of General Internal Medicine
Samuel F Ray, Shane R Wurdeman, Kota Z Takahashi
BACKGROUND: There are many studies that have investigated biomechanical differences among prosthetic feet, but not changes due to adaptation over time. There is a need for objective measures to quantify the process of adaptation for individuals with a transtibial amputation. Mechanical power and work profiles are a primary focus for modern energy-storage-and-return type prostheses, which strive to increase energy return from the prosthesis. The amount of energy a prosthesis stores and returns (i...
January 27, 2018: Journal of Neuroengineering and Rehabilitation
Joshua D Gross, Shane W Kaski, Adam B Schroer, Kimberley A Wix, David P Siderovski, Vincent Setola
Regulators of G protein signaling are proteins that accelerate the termination of effector stimulation after G protein-coupled receptor activation. Many regulators of G protein signaling proteins are highly expressed in the brain and therefore considered potential drug discovery targets for central nervous system pathologies; for example, here we show that RGS12 is highly expressed in microdissected mouse ventral striatum. Given a role for the ventral striatum in psychostimulant-induced locomotor activity, we tested whether Rgs12 genetic ablation affected behavioral responses to amphetamine and cocaine...
January 1, 2018: Journal of Psychopharmacology
Jon E Grant, Marc N Potenza, Shane W Kraus, Ismene L Petrakis
BACKGROUND: Disordered gambling behavior frequently co-occurs with alcohol dependence and other psychiatric conditions. Using data from a previously published trial, we conducted secondary analyses to examine the influence of problem-gambling features on treatment outcome for alcohol dependence or co-occurring psychopathology assessed via DSM-IV criteria. METHODS: Two hundred fifty-four patients with alcohol dependence and co-occurring psychiatric disorders were treated for 12 weeks in an outpatient medication study conducted at 3 Veterans Administration outpatient clinics from October 1998 to March 2002...
November 2017: Journal of Clinical Psychiatry
Marc Vetter, Joe Iwanaga, Rod J Oskouian, R Shane Tubbs
As lateral approaches gain popularity in lumbar spine surgery, detailed discussions regarding anatomical variations in the innervation of the thoracolumbar region are of increasing importance. Damage to intercostal or subcostal nerves can lead to post-operative complications including regional loss of sensitivity, motor function, or abdominal wall hernias. More specifically, the subcostal nerve has been identified in the literature as one of the more vulnerable structures during such procedures. A clear understanding of the position of the subcostal nerve relative to nearby anatomical structures is therefore important for medical professionals...
November 7, 2017: Curēus
Thomas W R Harrop, Shane Denecke, Ying Ting Yang, Janice Chan, Phillip J Daborn, Trent Perry, Philip Batterham
BACKGROUND: Nitenpyram is a member of the economically important neonicotinoid class of insecticides. The in vivo metabolism of nitenpyram is not well characterised, but cytochrome P450 activity is the major mechanism of resistance to neonicotinoids identified in insect pests, and P450s metabolise other neonicotinoids including imidacloprid. RESULTS: Here, we used the GAL4/UAS system to direct RNAi against the cytochrome P450 redox partners to interrupt P450 functions in specific tissues in Drosophila melanogaster...
January 9, 2018: Pest Management Science
Nabil Natafgi, Dan M Shane, Fred Ullrich, A Clinton MacKinney, Amanda Bell, Marcia M Ward
Introduction Tele-emergency can address several challenges facing emergency departments in rural areas. The purpose of this paper is to (a) examine the rates of avoided transfers in rural emergency departments that adopted tele-emergency applications; and (b) estimate the costs and benefits of using tele-emergency to avoid transfers. Methods Analysis is based on 9048 tele-emergency encounters generated by the Avera eEmergency programme (Sioux Falls, South Dakota) in 85 rural hospitals across seven states between October 2009-February 2014...
January 1, 2017: Journal of Telemedicine and Telecare
Danielle Milani, Adrienne J Bartlett, Shane R de Solla, Joanne L Parrott, Kyna D Intini, David Legault, Jennifer Unsworth, Vimal K Balakrishnan
Azo dyes are synthetic compounds used as industrial colorants, and some are predicted to be inherently toxic, bioaccumulative, and/or persistent based upon their chemical composition. This study addresses data gaps in current research which include the need to evaluate the toxicity of hydrophobic azo dyes to benthic invertebrates. The toxicity of a solvent dye, Sudan Red G (SRG), and two disperse dyes, Disperse Yellow 7 (DY7) and Disperse Orange 13 (DO13), to Hexagenia spp. and Tubifex tubifex was assessed in spiked-sediment exposures...
December 22, 2017: Environmental Science and Pollution Research International
Shehzad Khalid, R Shane Tubbs
We have reviewed here the neuroanatomical and neuropsychological literature of the human brain and have proposed the various pain mechanisms that we currently know of. Essentially when tissue is damaged, peripheral nociceptors are activated continuously and prostanoids are hence produced. Nonsteroidal anti-inflammatory drugs (NSAIDs) and medications aim to target these prostanoids to treat the inflammatory component of pain. Normal pain tends to have a protective response. It is important for the nervous system to learn and recognize this painful stimulus earlier and quicker with repeated exposure to avoid tissue damage...
October 6, 2017: Curēus
Tara Cessford, Graydon S Meneilly, Shane Arishenkoff, Christopher Eddy, Luke Y C Chen, Daniel J Kim, Irene W Y Ma
OBJECTIVES: To determine whether sonographic versions of physical examination techniques can accurately identify splenomegaly, Castell's method (Ann Intern Med 1967; 67:1265-1267), the sonographic Castell's method, spleen tip palpation, and the sonographic spleen tip technique were compared with reference measurements. METHODS: Two clinicians trained in bedside sonography patients recruited from an urban hematology clinic. Each patient was examined for splenomegaly using conventional percussion and palpation techniques (Castell's method and spleen tip palpation, respectively), as well as the sonographic versions of these maneuvers (sonographic Castell's method and sonographic spleen tip technique)...
December 8, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Shane M Regnier, Andrew G Kirkley, Daniel Ruiz, Wakanene Kamau, Qian Wu, Kurunthachalam Kannan, Robert M Sargis
Emerging evidence implicates environmental endocrine-disrupting chemicals (EDCs) in the pathogenesis of metabolic diseases such as obesity and diabetes; however, the interactions between EDCs and traditional risk factors in disease pathogenesis remain incompletely characterized. The present study interrogates the interaction of the EDC tolylfluanid (TF) and traditional dietary stressors in the promotion of metabolic dysfunction. Eight-week-old male C57BL/6 mice were fed a high-fat, high-sucrose diet (HFHSD) or a high-sucrose diet (HSD), with or without TF supplementation at 100 μg/g, for 12 weeks...
January 2018: Endocrine Connections
Amanda Estep, Steven Morrison, Shane Caswell, Jatin Ambegaonkar, Nelson Cortes
This study characterizes walking and running patterns in healthy individuals using linear and nonlinear methods Seventeen individuals (12 males, 5 females) volunteered for the study. 3D kinematic data during walking (WA) and running (RU) on a motorized treadmill were captured using reflective markers placed on lower body (200Hz). A single 25s trial (5000 data points) was collected for each gait task. WA speed was 1.39±0.12m/s, whereas RU speed was 2.56±0.27m/s. Variables of interest included ankle plantar/dorsi flexion, knee flexion/extension, knee abduction/adduction, hip flexion/extension, and hip abduction/adduction angles...
February 2018: Gait & Posture
Hillary L Shane, Ewa Lukomska, Aleksandr B Stefaniak, Stacey E Anderson
Didecyldimethylammonium bromide (DDAB) is a fourth generation dialkyl-quaternary ammonium compound (QAC) that is used in numerous products for its antimicrobial properties. While many QACs have been associated with allergic disease, the toxicity and sensitization of DDAB have not been thoroughly investigated. The purpose of these studies was to evaluate the irritancy and sensitization potential of DDAB following dermal application in a murine model. DDAB induced significant irritancy (0.0625-2%), evaluated by ear swelling in female BALB/c mice...
December 2017: Journal of Immunotoxicology
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