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giant cell granuloma maxilla

Allison N Rasband-Lindquist, Jonathan D Lindquist, Christopher G Larsen, Aaron Thiessen, Douglas Girod
Central giant-cell granulomas (CGCGs) are relatively uncommon. When they do occur, they typically arise in the mandible and maxilla. Some lesions are more destructive than others, and the destructive subtype has a tendency to recur. Unfortunately, there is no reproducible way to differentiate aggressive from nonaggressive subtypes. Treatment of CGCG has historically been based on surgical curettage or wide local excision. However, surgery has been associated with significant morbidity, disfigurement, and expense, as well as a high recurrence rate...
July 2016: Ear, Nose, & Throat Journal
Afsaneh Nekouei, Alireza Eshghi, Parisa Jafarnejadi, Zahra Enshaei
Peripheral giant cell granuloma is a common benign and reactive gingival epulis in oral cavity. It is often difficult to make a clinical diagnosis; thereby definitive diagnosis depends on histopathologic features. We report a case of a 4-year-old Caucasian boy presenting with a five-month history a 20 × 15 × 12 mm pedunculated, lobular soft tissue mass of the left anterior maxilla gingiva which was misdiagnosed and maltreated before his referral. An excisional biopsy of the lesion followed by histopathologic examination of the biopsy specimen revealed distinctive features of peripheral giant cell granuloma...
2016: Case Reports in Dentistry
Wael Said Ahmed
PURPOSE: The aim of this study was to evaluate the efficacy of ethanolamine oleate (EO) sclerotherapy in the treatment of peripheral giant cell granuloma. PATIENTS AND METHODS: This study included 24 patients presenting with PGCGs greater than 2 cm in diameter. Definitive diagnosis was confirmed after histopathologic examination of incisional biopsy specimens. EO sclerotherapy at a concentration of 2.5% was injected into each lesion once a week. Repeated injections were performed if needed...
April 30, 2016: Journal of Oral and Maxillofacial Surgery
Willian Ricardo Pires, Joao Paulo Bonardi, Leonardo Perez Faverani, Leonardo de Freitas Silva, Ana Carulina Rezende de Moraes Ferreira, Ana Paula Farnezi Bassi, Sonia Regina Panzarini, Daniela Ponzoni
No abstract text is available yet for this article.
May 2016: Journal of Craniofacial Surgery
M Dhiwakar, S Damodharan, K M Rajeshwari, S Mehta
BACKGROUND: Giant cell reparative granuloma of the facial skeleton is a rare presentation of hyperparathyroidism. METHODOLOGY: A 17-year-old girl presented with progressive expansile bony growths of the mandible and maxilla. The case was investigated using biopsies, blood tests, imaging, and surgery. RESULTS: Biopsies confirmed giant cell reparative granuloma. Blood testing revealed very high parathyroid hormone levels, and brown tumours due to primary hyperparathyroidism weresuspected...
2016: B-ENT
E K Bernard, M K Akama, A Vilembwa
Central giant cell granuloma (CGCG) appears to be a lesion that is unique to the jaws. It is difficult to predict its aggressiveness. A rare case of synchronous CGCG of the mandible and maxillar in a 14-year old boy is presented.
August 2012: East African Medical Journal
Michal Halperin-Sternfeld, Edmond Sabo, Sharon Akrish
BACKGROUND: Peri-implant soft tissue reactive lesions (I-RLs) may jeopardize implant success and survival. To the best of the authors' knowledge, its pathogenesis is unknown. The objective of this study is to conduct a clinicopathologic and polarized light microscopy (PLM) analysis of 14 new I-RLs and compare them with comparable tooth-associated cases (T-RLs) to better understand I-RL pathogenesis. METHODS: Fifty-eight new cases of I-RL and T-RL were retrieved from the pathology department archives of Rambam Health Care Campus, Haifa, Israel...
May 2016: Journal of Periodontology
Somit Mittal, Iqbal Naseem, Kafil Akhtar, Ibne Ahmad, Mohd Khalid
Giant cell reparative granuloma (GCRG) is a rare lesion that is a reactive process, not a true neoplasm. It was originally coined by Jaffe to describe lesions, which he believed were a response to intraosseous hemorrhage from jaw trauma. Regardless, GCRG is much more distinct from giant cell tumor (GCT) of bone, both histologically and clinically. We report a patient who presented with multiple facial swelling involving the facial skeleton that showed a multiloculated cystic appearance on CT involving the maxilla and mandible...
July 2015: Annals of Saudi Medicine
Anna Janas, Piotr Osica
UNLABELLED: Central giant cell granuloma is a rare occurring tumor-like lesion of the facial part of the skull, located more often in mandible (from 2:1 to 3:1), than in the maxilla. It accounts for 7% of all benign tumors of the jaws, whereas the brown tumor is a complication of a primary hyperparathyroidism and occurs in approximately 4.5%, or in 1.5%, when the tumor is a complication of secondary hyperparathyroidism. However, the brown tumor is significantly less often observed than the presented lesion...
April 2015: Developmental Period Medicine
Srinath Krishnappa, Sahana Srinath, Pavana Gopinath, Vishwanath S Krishnappa
Central giant cell granulomas (CGCG) are reddish lesions of gingiva that account for an important number of disorders frequently diagnosed in the regular dental practice. Although the majority of the lesions are nonaggressive, asymptomatic, and slow-growing, about 30% show an aggressive, progressively destructive behavior, and a tendency to recur. We present a case of aggressive CGCG of the maxilla in a 4-year-old female child managed by surgical excision. To minimize the possible cost of esthetic, functional, and psychological problems, mainly in young patients, CGCG should be diagnosed and managed at the earliest...
October 2015: Journal of the Indian Society of Pedodontics and Preventive Dentistry
Andrea Maturana-Ramírez, Daniela Adorno-Farías, Montserrat Reyes-Rojas, Marcela Farías-Vergara, Juan Aitken-Saavedra
UNLABELLED: The aim of this study was to determine the relative frequency and distribution of reactive hyperplastic lesions (RHL) of the oral mucosa at the Oral Pathology Institute of the School of Dentistry at the University of Chile. This was a retrospective study of 1149 biopsies with histopathological diagnosis of RHL, performed between 2000 and 2011. The RHL were classified in 4 groups: fibrous hyperplasia (FH), pyogenic granuloma (PG), peripheral giant-cell granuloma (PGCG) and peripheral ossifying fibroma (POF)...
2015: Acta Odontológica Latinoamericana: AOL
Yasuhiro Arai, Yoshihiro Chiba, Shigeaki Umeda, Yoshihito Ohara, Toshinori Iwai, Masanori Komatsu, Kenichiro Yabuki, Daisuke Sano, Nobuhiko Oridate
Both central giant cell granuloma (CGCG) and ossifying fibroma (OF) are relatively common diseases. The synchronous presentation of CGCG and OF is, however, an extremely rare occurrence. We present an unusual case with the synchronous presentation of these two diseases in the maxilla and introduce a surgical strategy based on a combination of the stereolithographic model and navigation system for the treatment of gigantic OF with secondary CGCG.
April 2016: Auris, Nasus, Larynx
Anita Munde, Priyanka Modi, Ravindra Karle, Pranali Wankhede, Safia Shoeb
Central giant cell granuloma (CGCG) is a benign proliferation of fibroblasts and multinucleated giant cells that almost exclusively occurs in the jaws. It commonly occurs in young adults showing a female predilection in the anterior mandible. Multifocal CGCGs in maxillofacial region are very rare and suggestive of systemic diseases such as hyperparathyroidism, an inherited syndrome such as Noonan-like multiple giant cell lesion syndrome or other disorders. Only 10 cases of multifocal CGCGs in the maxillofacial region without any concomitant systemic disease have been reported in the English literature...
February 2015: Journal of Dentistry of Tehran University of Medical Sciences
Elisa Fernández-Cooke, Jaime Cruz-Rojo, Carmen Gallego, Ana Isabel Romance, Rocio Mosqueda-Peña, Yolanda Almaden, Jaime Sánchez del Pozo
Tumor-induced osteomalacia/rickets is a rare paraneoplastic disorder associated with a tumor-producing fibroblast growth factor 23 (FGF23). We present a child with symptoms of rickets as the first clinical sign of a central giant cell granuloma (CGCG) with high serum levels of FGF23, a hormone associated with decreased phosphate resorption. A 3-year-old boy presented with a limp and 6 months later with painless growth of the jaw. On examination gingival hypertrophy and genu varum were observed. Investigations revealed hypophosphatemia, normal 1,25 and 25 (OH) vitamin D, and high alkaline phosphatase...
June 2015: Pediatrics
Koji Akeda, Yuichi Kasai, Toshihiko Sakakibara, Akihiko Matsumine, Norihiko Takegami, Junichi Yamada, Akihiro Sudo
STUDY DESIGN: A case of recurrent giant cell reparative granuloma (GCRG) of the lumbar spine successfully treated with denosumab is reported; a fully human monoclonal antibody against the receptor activator of nuclear factor kappa B (RANK) ligand (RANKL). OBJECTIVE: To report the first case of recurrent GCRG of the lumbar spine treated with denosumab. SUMMARY OF BACKGROUND DATA: GCRG is a non-neoplastic osteofibrous lesion usually found in the maxilla and mandible but rarely in the spine...
May 15, 2015: Spine
Deepanshu Gulati, Vishal Bansal, Prajesh Dubey, Sanjay Pandey, Abhinav Agrawal
A case of 19-year-old male patient reported with the chief complaint of slowly growing diffuse painless swelling over the right part of the face from last 6 months. Intraoral examination revealed a swelling on right side of palate in relation to molar region with buccal cortical plate expansion. Radiographic examination (orthopantograph and 3DCT) showed large multilocular radiolucency in right maxilla with generalized loss of lamina dura. Incisional biopsy was done and specimen was sent for histopathological examination which showed multinucleated giant cells containing 15-30 nuclei...
2015: Case Reports in Endocrinology
Nathan Eivaz, Vatsal Patel, William O Collins
No abstract text is available yet for this article.
March 2015: JAMA Otolaryngology—Head & Neck Surgery
E Cayci, B Kan, E Guzeldemir-Akcakanat, B Muezzinoglu
Peripheral giant cell reparative granuloma is a reactive and rare lesion of oral cavity with unknown etiology which is derived from periosteum and periodontal ligament and occurs frequently in young adults. Inflammation or trauma is underlying causative factor of reactive proliferation. In the present case report, a 35 year-old male with aggressive periodontitis and peripheral giant cell reparative granuloma is presented. The patient applied to our clinic with a complaining about a big nodule at his palate...
September 2014: Oral Health and Dental Management
Arash Mirmohammadsadeghi, Bahram Eshraghi, Azadeh Shahsanaei, Raheleh Assari
PURPOSE: To report 3 cases of cherubism, one of whom underwent surgery for orbital manifestations, and to provide a literature review. CASE REPORTS: Our patients were normal at birth and developed painless enlarging of the cheeks and jaws when they were 4-5 years old. Ophthalmologic examinations showed mild proptosis, superior globe displacement and inferior scleral show in all cases. Cases 2 and 3 had lower lid skin discoloration. Computed tomography (CT) scans demonstrated bilateral multicystic lesions in the maxilla and mandible with cortical thinning in all cases...
February 2015: Orbit
Fetin R Yildiz, Arzu Avci, Omür Dereci, Behcet Erol, Bulent Celasun, Omer Gunhan
Osteosarcoma is the most frequent primary gnathic sarcoma. Neither the etiology nor the variables effecting the prognosis are fully known due mostly to the rarity of gnathic osteosarcomas. To date a considerable number of clinicopathologic features have been suggested in the evaluation of gnathic osteosarcomas. Still there is a need to experience on several aspects of management. The aim of this study is to report a series of 33 cases of osteosarcoma involving either mandible or maxilla. The clinical, radiological and histopathological features of our cases have usually been non-specific and the most frequent provisional diagnosis were "benign fibroosseous lesion, abnormal mass, giant cell granuloma and benign bone tumor"...
2014: International Journal of Clinical and Experimental Pathology
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