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https://www.readbyqxmd.com/read/27623975/can-first-trimester-maternal-serum-follistatin-like-3-levels-predict-the-development-of-gestational-diabetes-mellitus
#1
Ayse Yasemin Karageyim Karsidag, Yunus Emre Purut, Esra Esim Buyukbayrak, Asuman Orçun, Mehmet Menke
PURPOSE: To determine whether the first trimester maternal serum levels of follistatin like 3 (FSTL3) are altered in patients who develop gestational diabetes mellitus (GDM). METHODS: This is a prospective nested case-control study that included 170 singleton pregnant women recruited in their first trimester. All women were followed up until the delivery and 144 of them completed the study. The maternal serum levels of FSTL3 were measured at 11-14 weeks of gestation...
September 14, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27560381/comparison-of-normal-and-pre-eclamptic-placental-gene-expression-a-systematic-review-with-meta-analysis
#2
O Brew, M H F Sullivan, A Woodman
Pre-eclampsia (PE) is a serious multi-factorial disorder of human pregnancy. It is associated with changes in the expression of placental genes. Recent transcription profiling of placental genes with microarray analyses have offered better opportunities to define the molecular pathology of this disorder. However, the extent to which placental gene expression changes in PE is not fully understood. We conducted a systematic review of published PE and normal pregnancy (NP) control placental RNA microarrays to describe the similarities and differences between NP and PE placental gene expression, and examined how these differences could contribute to the molecular pathology of the disease...
2016: PloS One
https://www.readbyqxmd.com/read/27324248/identification-of-the-key-regulating-genes-of-diminished-ovarian-reserve-dor-by-network-and-gene-ontology-analysis
#3
Maryam Pashaiasl, Mansour Ebrahimi, Esmaeil Ebrahimie
Diminished ovarian reserve (DOR) is one of the reasons for infertility that not only affects both older and young women. Ovarian reserve assessment can be used as a new prognostic tool for infertility treatment decision making. Here, up- and down-regulated gene expression profiles of granulosa cells were analysed to generate a putative interaction map of the involved genes. In addition, gene ontology (GO) analysis was used to get insight intol the biological processes and molecular functions of involved proteins in DOR...
September 2016: Molecular Biology Reports
https://www.readbyqxmd.com/read/26770512/association-of-follistatin-like-3-concentrations-in-serum-and-synovial-fluid-with-the-radiographic-severity-of-knee-osteoarthritis
#4
Gang Liu, Si Chen, Shucai Deng, Xinlong Ma, Yonghong Hao, Guoyun Bu
OBJECTIVE: Follistatin-like 3 (FSTL3), a circulating glycoprotein, is correlated with obesity and inflammation, which are potential mechanisms of osteoarthritis (OA). This study aims to determine the correlation of FSTL3 concentrations in serum and synovial fluid (SF) with the radiographic severity of OA. METHODS: This study consisted of 200 patients with knee OA and 148 healthy controls. The radiological grading of OA in the knee was performed in accordance with Kellgren-Lawrence (KL) grading system...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26727106/activin-enhances-%C3%AE-to-%C3%AE-cell-transdifferentiation-as-a-source-for-%C3%AE-cells-in-male-fstl3-knockout-mice
#5
Melissa L Brown, Danielle Andrzejewski, Amy Burnside, Alan L Schneyer
Diabetes results from inadequate β-cell number and/or function to control serum glucose concentrations so that replacement of lost β-cells could become a viable therapy for diabetes. In addition to embryonic stem cell sources for new β-cells, evidence for transdifferentiation/reprogramming of non-β-cells to functional β-cells is accumulating. In addition, de-differentiation of β-cells observed in diabetes and their subsequent conversion to α-cells raises the possibility that adult islet cell fate is malleable and controlled by local hormonal and/or environmental cues...
March 2016: Endocrinology
https://www.readbyqxmd.com/read/26629006/follistatin-like-3-suppresses-cell-proliferation-and-fibronectin-expression-via-p38mapk-pathway-in-rat-mesangial-cells-cultured-under-high-glucose
#6
Xiaohong Wang, Liyin Shi, Zhe Han, Baoshan Liu
Mesangial cells (MCs) proliferation and extracellular matrix (ECM) accumulation are early features of diabetic nephropathy. Follistatin-like 3 (FSTL3), a member of follistatin family, has been shown to regulate insulin and glucagon sensitivities in diet-induced obesity and insulin resistance. However, the role of FSTL3 in diabetic nephropathy is still unclear. Therefore, in this study, we investigated the effects of FSTL3 on cell proliferation and ECM accumulation expression in rat MCs cultured under high glucose, and elucidated the underlying mechanism...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26397694/fstl3-mediates-exercise-driven-bone-formation
#7
Michael Larsen, Sudha Agarwal
No abstract text is available yet for this article.
October 2015: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/26388242/gene-expression-profiling-of-pre-eclamptic-placentae-by-rna-sequencing
#8
Tea Kaartokallio, Alejandra Cervera, Anjuska Kyllönen, Krista Laivuori
Pre-eclampsia is a common and complex pregnancy disorder that often involves impaired placental development. In order to identify altered gene expression in pre-eclamptic placenta, we sequenced placental transcriptomes of nine pre-eclamptic and nine healthy pregnant women in pools of three. The differential gene expression was tested both by including all the pools in the analysis and by excluding some of the pools based on phenotypic characteristics. From these analyses, we identified altogether 53 differently expressed genes, a subset of which was validated by qPCR in 20 cases and 19 controls...
September 21, 2015: Scientific Reports
https://www.readbyqxmd.com/read/25961841/activins-a-and-b-regulate-fate-determining-gene-expression-in-islet-cell-lines-and-islet-cells-from-male-mice
#9
Danielle Andrzejewski, Melissa L Brown, Nathan Ungerleider, Amy Burnside, Alan L Schneyer
TGFβ superfamily ligands, receptors, and second messengers, including activins A and B, have been identified in pancreatic islets and proposed to have important roles regulating development, proliferation, and function. We previously demonstrated that Fstl3 (an antagonist of activin activity) null mice have larger islets with β-cell hyperplasia and improved glucose tolerance and insulin sensitivity in the absence of altered β-cell proliferation. This suggested the hypothesis that increased activin signaling influences β-cell expansion by destabilizing the α-cell phenotype and promoting transdifferentiation to β-cells...
July 2015: Endocrinology
https://www.readbyqxmd.com/read/25937185/follistatin-like-3-is-a-mediator-of-exercise-driven-bone-formation-and-strengthening
#10
J Nam, P Perera, R Gordon, Y H Jeong, A D Blazek, D G Kim, B C Tee, Z Sun, T D Eubank, Y Zhao, B Lablebecioglu, S Liu, A Litsky, N L Weisleder, B S Lee, T Butterfield, A L Schneyer, S Agarwal
Exercise is vital for maintaining bone strength and architecture. Follistatin-like 3 (FSTL3), a member of follistatin family, is a mechanosensitive protein upregulated in response to exercise and is involved in regulating musculoskeletal health. Here, we investigated the potential role of FSTL3 in exercise-driven bone remodeling. Exercise-dependent regulation of bone structure and functions was compared in mice with global Fstl3 gene deletion (Fstl3-/-) and their age-matched Fstl3+/+ littermates. Mice were exercised by low-intensity treadmill walking...
September 2015: Bone
https://www.readbyqxmd.com/read/25456456/over-expression-of-follistatin-like-3-attenuates-fat-accumulation-and-improves-insulin-sensitivity-in-mice
#11
Claus Brandt, Rasmus Hvass Hansen, Jakob Bondo Hansen, Caroline Holkmann Olsen, Pia Galle, Thomas Mandrup-Poulsen, Julie Gehl, Bente Klarlund Pedersen, Pernille Hojman
OBJECTIVE: Follistatin-like 3 (fstl3), a natural inhibitor of members of the TGF-β family, increases during resistance training in human plasma. Fstl3 primarily binds myostatin and activin A, and thereby inhibits their functions. We hypothesize that blocking myostatin and activin A signalling through systemic fstl3 over-expression protects against diet-induced obesity and insulin resistance. METHODS: Fstl3 was over-expressed by DNA electrotransfer in tibialis anterior, quadriceps and gastrocnemius muscles in female C57BL/C mice, and the mice were subsequently randomized to chow or high-fat feeding...
February 2015: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/25104880/obesity-and-low-grade-inflammation-increase-plasma-follistatin-like-3-in-humans
#12
Claus Brandt, Maria Pedersen, Anders Rinnov, Anne S Andreasen, Kirsten Møller, Pernille Hojman, Bente K Pedersen, Peter Plomgaard
BACKGROUND: Rodent models suggest that follistatin-like 3 (fstl3) is associated with diabetes and obesity. In humans, plasma fstl3 is reduced with gestational diabetes. In vitro, TNF-α induces fstl3 secretion, which suggests a link to inflammation. OBJECTIVE: To elucidate the association between plasma fstl3 and obesity, insulin resistance, and low-grade inflammation in humans. STUDY DESIGN: Plasma fstl3 levels were determined in a cross-sectional study including three groups: patients with type 2 diabetes, impaired glucose tolerance, and healthy controls...
2014: Mediators of Inflammation
https://www.readbyqxmd.com/read/24763182/serum-activin-a-and-follistatin-levels-in-gestational-diabetes-and-the-association-of-the-activin-a-follistatin-system-with-anthropometric-parameters-in-offspring
#13
Silvia Näf, Xavier Escote, Mónica Ballesteros, Rosa Elena Yañez, Inmaculada Simón-Muela, Pilar Gil, Gerard Albaiges, Joan Vendrell, Ana Megia
CONTEXT: The Activin A-Follistatin system has emerged as an important regulator of lipid and glucose metabolism with possible repercussions on fetal growth. OBJECTIVE: To analyze circulating activin A, follistatin and follistatin-like-3 (FSTL3) levels and their relationship with glucose metabolism in pregnant women and their influence on fetal growth and neonatal adiposity. DESIGN AND METHODS: A prospective cohort was studied comprising 207 pregnant women, 129 with normal glucose tolerance (NGT) and 78 with gestational diabetes mellitus (GDM) and their offspring...
2014: PloS One
https://www.readbyqxmd.com/read/24588779/follistatin-like-5-is-expressed-in-restricted-areas-of-the-adult-mouse-brain-implications-for-its-function-in-the-olfactory-system
#14
Tomoyuki Masuda, Chie Sakuma, Atsuko Nagaoka, Toshiyuki Yamagishi, Shuichi Ueda, Takahiro Nagase, Hiroyuki Yaginuma
Follistatin-like 5 (Fstl5), a member of the follistatin family of genes, encodes a secretory glycoprotein. Previous studies revealed that other members of this family including Fstl1 and Fstl3 play an essential role in development, homeostasis, and congenital disorders. However, the in vivo function of Fstl5 is poorly understood. To gain insight into the function of Fstl5 in the mouse central nervous system, we examined the Fstl5 expression pattern in the adult mouse brain. The results of in situ hybridization analysis showed a highly restricted pattern of Fstl5, namely, with localization in the olfactory system, hippocampal CA3 area and granular cell layer of the cerebellum...
February 2014: Congenital Anomalies
https://www.readbyqxmd.com/read/24505115/phosphoprotein-secretome-of-tumor-cells-as-a-source-of-candidates-for-breast-cancer-biomarkers-in-plasma
#15
Anna M Zawadzka, Birgit Schilling, Michael P Cusack, Alexandria K Sahu, Penelope Drake, Susan J Fisher, Christopher C Benz, Bradford W Gibson
Breast cancer is a heterogeneous disease whose molecular diversity is not well reflected in clinical and pathological markers used for prognosis and treatment selection. As tumor cells secrete proteins into the extracellular environment, some of these proteins reach circulation and could become suitable biomarkers for improving diagnosis or monitoring response to treatment. As many signaling pathways and interaction networks are altered in cancerous tissues by protein phosphorylation, changes in the secretory phosphoproteome of cancer tissues could reflect both disease progression and subtype...
April 2014: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/23667740/the-expression-of-embryonic-liver-development-genes-in-hepatitis-c-induced-cirrhosis-and-hepatocellular-carcinoma
#16
Martha Behnke, Mark Reimers, Robert Fisher
Hepatocellular carcinoma (HCC) remains a difficult disease to study even after a decade of genomic analysis. Patient and disease heterogeneity, differences in statistical methods and multiple testing issues have resulted in a fragmented understanding of the molecular basis of tumor biology. Some researchers have suggested that HCC appears to share pathways with embryonic development. Therefore we generated targeted hypotheses regarding changes in developmental genes specific to the liver in HCV-cirrhosis and HCV-HCC...
September 1, 2012: Cancers
https://www.readbyqxmd.com/read/23533219/increased-activin-bioavailability-enhances-hepatic-insulin-sensitivity-while-inducing-hepatic-steatosis-in-male-mice
#17
Nathan A Ungerleider, Lara M Bonomi, Melissa L Brown, Alan L Schneyer
The development of insulin resistance is tightly linked to fatty liver disease and is considered a major health concern worldwide, although their mechanistic relationship remains controversial. Activin has emerging roles in nutrient homeostasis, but its metabolic effects on hepatocytes remain unknown. In this study, we investigated the effects of increased endogenous activin bioactivity on hepatic nutrient homeostasis by creating mice with inactivating mutations that deplete the circulating activin antagonists follistatin-like-3 (FSTL3) or the follistatin 315 isoform (FST315; FST288-only mice)...
June 2013: Endocrinology
https://www.readbyqxmd.com/read/23407452/follistatin-like-3-fstl3-mediated-silencing-of-transforming-growth-factor-%C3%AE-tgf%C3%AE-signaling-is-essential-for-testicular-aging-and-regulating-testis-size
#18
Karla J Oldknow, Jan Seebacher, Tapasree Goswami, Judit Villen, Andrew A Pitsillides, Peter J O'Shaughnessy, Steven P Gygi, Alan L Schneyer, Abir Mukherjee
Follistatin-like 3 (FSTL3) is a glycoprotein that binds and inhibits the action of TGFβ ligands such as activin. The roles played by FSTL3 and activin signaling in organ development and homeostasis are not fully understood. The authors show mice deficient in FSTL3 develop markedly enlarged testes that are also delayed in their age-related regression. These FSTL3 knockout mice exhibit increased Sertoli cell numbers, allowing for increased spermatogenesis but otherwise showing normal testicular function. The data show that FSTL3 deletion leads to increased AKT signaling and SIRT1 expression in the testis...
March 2013: Endocrinology
https://www.readbyqxmd.com/read/23164397/expression-patterns-of-activin-inhibin-and-follistatin-variants-in-the-adult-male-mouse-reproductive-tract-suggest-important-roles-in-the-epididymis-and-vas-deferens
#19
Wendy R Winnall, Hui Wu, Mai A Sarraj, Peter A W Rogers, David M de Kretser, Jane E Girling, Mark P Hedger
Activin A and its inhibitors follistatin and inhibin play key roles in development and function of the male reproductive tract. Quantitative (q) polymerase chain reaction (PCR) was used to evaluate the expression of Inhba (the gene encoding activin A subunits), Inha and Inhbb (genes encoding the inhibin B subunits), as well as the genes for follistatin (Fst) and follistatin-like 3 (Fstl3) and the activin receptor subunits, in the male mouse reproductive tract. A qPCR assay that discriminated between the two follistatin variants of Fst288 (tissue-bound form) and Fst315 (circulating) was established...
2013: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/23045716/fsh-and-lh-have-common-and-distinct-effects-on-gene-expression-in-rainbow-trout-testis
#20
Elisabeth Sambroni, Antoine D Rolland, Jean-Jacques Lareyre, Florence Le Gac
The general rules established from mammalian species for the regulation of spermatogenesis by gonadotropins may not be fully relevant in fish. Particularly, Fsh is as potent as Lh to stimulate steroidogenesis and the Fsh receptor is expressed in Leydig cells. In seasonal breeders, Fsh is likely the major gonadotropin involved in spermatogenesis onset and Lh is required to support spermatogenesis progression and gamete release. However, the genes that relay the action of Fsh and Lh have been poorly investigated in fish...
February 2013: Journal of Molecular Endocrinology
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