keyword
MENU ▼
Read by QxMD icon Read
search

cross x linked

keyword
https://www.readbyqxmd.com/read/28822839/decreased-surface-expression-of-the-%C3%AE-subunit-of-the-gabaa-receptor-contributes-to-reduced-tonic-inhibition-in-dentate-granule-cells-in-a-mouse-model-of-fragile-x-syndrome
#1
Nianhui Zhang, Zechun Peng, Xiaoping Tong, A Kerstin Lindemeyer, Yliana Cetina, Christine S Huang, Richard W Olsen, Thomas S Otis, Carolyn R Houser
While numerous changes in the GABA system have been identified in models of Fragile X Syndrome (FXS), alterations in subunits of the GABAA receptors (GABAARs) that mediate tonic inhibition are particularly intriguing. Considering the key role of tonic inhibition in controlling neuronal excitability, reduced tonic inhibition could contribute to FXS-associated disorders such as hyperactivity, hypersensitivity, and increased seizure susceptibility. The current study has focused on the expression and function of the δ subunit of the GABAAR, a major subunit involved in tonic inhibition, in granule cells of the dentate gyrus in the Fmr1 knockout (KO) mouse model of FXS...
August 16, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28821063/development-and-characterization-of-banana-flour-film-incorporated-with-montmorillonite-and-banana-starch-nanoparticles
#2
Aungkana Orsuwan, Rungsinee Sothornvit
Banana flour film is an alternative biopolymer material but still needs improvement of its mechanical properties and water vapor permeability. Banana starch nanoparticles (BSNs), prepared using miniemulsion cross-linking, make an interesting reinforcing agent. The properties of plasticized banana flour film (PBF) were characterized incorporated with 5% (w/w) of either montmorillonite; MMT-Na(+) (PBF-M) or BSN (PBF-B), including a mixture of nanoparticles at 1:1 for 5% (PBF-MB5) and 10% (PBF-MB10). PBF-MB5 provided better improvement in the film mechanical and water barrier properties compared with PBF-B...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820997/nh2fe3o4-sio2-supported-peroxidase-catalyzed-h2o2-for-degradation-of-endocrine-disrupter-from-aqueous-solution-roles-of-active-radicals-and-noms
#3
Jing Ai, Weijun Zhang, Guiying Liao, Hua Xia, Dongsheng Wang
In this work, magnetic Fe3O4 was utilized to immobilize horseradish peroxidase (IM-HRP) in order to improve its stability and reusability by crosslinking method process with glutaraldehyde. The physicochemical properties of NH2Fe3O4@SiO2 and IM-HRP were characterized by powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Thermo-gravimetric Analysis (TGA) and Transmission electron microscopy (TEM). The thermal stability of immobilized-HRP was considerably improved in comparison with free counterpart...
August 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28820695/prevalence-and-seroprevalence-of-trypanosoma-cruzi-infection-in-a-military-population-in-texas
#4
Bryant J Webber, Mary T Pawlak, Sandra Valtier, Candelaria C Daniels, Charla C Tully, Edward J Wozniak, Walter D Roachell, Francisco X Sanchez, Audra A Blasi, Thomas L Cropper
Recent biosurveillance findings at Joint Base San Antonio (JBSA), a large military installation located in south-central Texas, indicate the potential for vector-borne human Chagas disease. A cross-sectional study was conducted to determine the prevalence and seroprevalence of Trypanosoma cruzi infection in highest risk subpopulations on the installation, including students and instructors who work and sleep in triatomine-endemic field settings. Real-time polymerase chain reaction, enzyme-linked immunosorbent assay, and indirect immunofluorescent antibody assay were performed on enrolled subjects (N = 1,033), none of whom tested positive for T...
August 14, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28815664/simultaneous-lateral-bone-augmentation-and-implant-placement-using-a-particulated-synthetic-bone-substitute-around-chronic-peri-implant-dehiscence-defects-in-dogs
#5
Ui-Won Jung, Jae-Kook Cha, Fabio Vignoletti, Javier Nuñez, Javier Sanz, Mariano Sanz
AIM: To determine the histological outcomes when using a highly porous synthetic bone substitute and a cross-linked collagen membrane for lateral bone augmentation of peri-implant dehiscence defects. METHODS: In 8 dogs, three treatment groups were randomly allocated at each peri-implant dehiscence defect (mean height x depth = 3 x 1 mm): (i) synthetic bone substitute covered by a cross-linked collagen membrane (test group), (ii) deproteinized bovine bone mineral covered by a natural collagen membrane (positive control), and (iii) no treatment (negative control)...
August 16, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28815245/-experimental-study-on-osteogenesis-of-acellular-porcine-pericardium-in-guided-bone-regeneration
#6
Jun-Zhao Gao, Xue-Jian Zhang, Jia-Li Hou, Yue Deng, Yun-Peng Li
PURPOSE: To observe the retention time and effect of acellular porcine pericardium (APP) in bone regeneration for rabbit femoral bone defects. METHODS: APP was prepared as follows: fresh porcine pericardium was chosen, high and low osmotic NaCl solution were used to soak the specimen alternately, trypsin+EDTA were used for digest, and then immersed with TritonX-100, cross-linked by using glutaraldehyde. 24 New Zealand rabbits were selected, and the area of bone defect was created 8 mm×8 mm×5 mm in size on bilateral distal femur...
April 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28802246/preparation-and-adsorption-characteristics-of-an-ion-imprinted-polymer-for-fast-removal-of-ni-ii-ions-from-aqueous-solution
#7
Zhiyong Zhou, Delong Kong, Huiying Zhu, Nian Wang, Zhuo Wang, Qi Wang, Wei Liu, Qunsheng Li, Weidong Zhang, Zhongqi Ren
A novel Ni(II) ion-imprinted polymer (IIP) was synthesized by bulk polymerization for fast removal of Ni(II) ions from aqueous solution. Effects of preparation conditions on adsorption performance were investigated. Diphenylcarbazide (DPC) and N,N-azobisisobutyronitrile (AIBN) were used as ligand and initiator, respectively. Various monomers, solvents, cross-linking agents and molar ratios of template, monomer and cross-linking agent for polymerization were studied to obtain the largest adsorption capacity...
June 8, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28796484/superhydrophobic-superoleophilic-and-reinforced-ethyl-cellulose-sponges-for-oil-water-separation-synergistic-strategies-of-cross-linking-carbon-nanotube-composite-and-nanosilica-modification
#8
Yeqiang Lu, Weizhong Yuan
Superhydrophobic/superoleophilic and reinforced ethyl cellulose (SEC) sponges were prepared by cross-linking EC with epichlorohydrin (ECH) and complexing with silanized carbon nanotubes (Si-CNTs) followed by coating nanosilica on the surface of porous sponges and subsequent modification with hexadecyltrimethoxysilane (HDTMS). These synergistic strategies endowed the SEC sponges with the superhydrophobic/superoleophilic properties (θwater=158.2°, θoil=0°, sliding angle=3°) and outstanding mechanical properties (could bear the pressure of 28...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28795725/rational-design-of-artificial-dye-decolorizing-peroxidases-using-myoglobin-by-engineering-tyr-trp-in-the-heme-center
#9
Le-Le Li, Hong Yuan, Fei Liao, Bo He, Shu-Qin Gao, Ge-Bo Wen, Xiangshi Tan, Ying-Wu Lin
The rational design of metalloenzymes provides advantages not only for illustrating the structure and function relationship of native enzymes, but also for creating functional artificial enzymes comparable to native enzymes. Dye-decolorizing peroxidases (DyPs) are a new family of heme peroxidases and have received much attention recently. Inspired by the structural features of native DyPs with multiple Tyr and Trp residues, we herein aimed to design functional artificial DyPs using myoglobin (Mb), an O2 carrier as a protein scaffold, by further introduction of Tyr/Trp into the secondary sphere of the heme center in the F43Y Mb mutant...
August 10, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28794184/post-transcriptional-regulation-of-mouse-neurogenesis-by-pumilio-proteins
#10
Meng Zhang, Dong Chen, Jing Xia, Wenqi Han, Xiekui Cui, Nils Neuenkirchen, Gretchen Hermes, Nenad Sestan, Haifan Lin
Despite extensive studies on mammalian neurogenesis, its post-transcriptional regulation remains under-explored. Here we report that neural-specific inactivation of two murine post-transcriptional regulators, Pumilio 1 (Pum1) and Pum2, severely reduced the number of neural stem cells (NSCs) in the postnatal dentate gyrus (DG), drastically increased perinatal apoptosis, altered DG cell composition, and impaired learning and memory. Consistently, the mutant DG neurospheres generated fewer NSCs with defects in proliferation, survival, and differentiation, supporting a major role of Pum1 and Pum2 in hippocampal neurogenesis and function...
August 9, 2017: Genes & Development
https://www.readbyqxmd.com/read/28793987/testing-the-direction-of-effects-between-child-body-composition-and-restrictive-feeding-practices-results-from-a-population-based-cohort
#11
Ivonne Pm Derks, Henning Tiemeier, Eric Jg Sijbrands, Jan M Nicholson, Trudy Voortman, Frank C Verhulst, Vincent Wv Jaddoe, Pauline W Jansen
Background: Parental restrictive feeding (i.e., limiting food intake of children) has been linked to childhood overweight. However, the directionality of the causal pathway remains unknown.Objective: The objectives of this study were to examine the bidirectional association of maternal restrictive feeding with children's weight and body composition across childhood and to explore a possible mediating role of maternal concern about child weight.Design: Data were available for 4689 mother-child dyads participating in Generation R, a prospective birth cohort in the Netherlands...
August 9, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28793758/identifying-key-structural-features-of-irox-water-splitting-catalysts
#12
Elena Willinger, Cyriac Massué, Robert Schlögl, Marc-Georg Willinger
Hydrogen production by electrocatalytic water splitting will play a key role in the realization of a sustainable energy supply. Owing to their relatively high stability and activity, iridium (hydr)oxides have been identified as most promising catalysts for the oxidation of water. Comprehensive spectroscopic and theoretical studies on the basis of Rutile IrO2 have provided insight about the electronic structure of the active X-ray amorphous phase. However, due to the absence of long-range order and missing information about the local arrangement of structural units, our present understanding of the active phase is very unsatisfying...
August 9, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28774821/a-pdz-like-domain-mediates-the-dimerization-of-11r-lipoxygenase
#13
Priit Eek, Kaspar Põldemaa, Sergo Kasvandik, Ivar Järving, Nigulas Samel
Lipoxygenases (LOXs), participating in inflammatory processes and cancer, are a family of enzymes with high potential as drug targets. Various allosteric effects have been observed with different LOX isozymes (e.g. lipid/ATP binding, phosphorylation), yet there is a lot of uncertainty concerning the regulation of these enzymes. It has been recently found that a number of LOXs form dimers, extending the list of possible allosteric mechanisms with oligomerization. Coral 11R-LOX is, unlike several mammalian counterparts, a stable dimer in solution facilitating quaternary structure studies that demand high sample homogeneity...
July 31, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28773235/synchrotron-microtomography-reveals-the-fine-three-dimensional-porosity-of-composite-polysaccharide-aerogels
#14
Abdul Ghafar, Kirsti Parikka, David Haberthür, Maija Tenkanen, Kirsi S Mikkonen, Jussi-Petteri Suuronen
This study investigates the impact of ice-templating conditions on the morphological features of composite polysaccharide aerogels in relation to their mechanical behavior and aims to get a better insight into the parameters governing these properties. We have prepared polysaccharide aerogels of guar galactomannan (GM) and tamarind seed xyloglucan (XG) by enzymatic oxidation with galactose oxidase (GaO) to form hydrogels, followed by conventional and unidirectional ice-templating (freezing) methods and lyophilization to form aerogels...
July 28, 2017: Materials
https://www.readbyqxmd.com/read/28773012/simultaneously-toughening-and-strengthening-soy-protein-isolate-based-composites-via-carboxymethylated-chitosan-and-halloysite-nanotube-hybridization
#15
Xiaorong Liu, Haijiao Kang, Zhong Wang, Wei Zhang, Jianzhang Li, Shifeng Zhang
Chemical cross-linking modification can significantly enhance the tensile strength (TS) of soy protein isolate (SPI)-based composites, but usually at the cost of a reduction in the elongation at break (EB). In this study, eco-friendly and high-potential hybrid SPI-based nanocomposites with improved TS were fabricated without compromising the reduction of EB. The hybrid of carboxymethylated chitosan (CMCS) and halloysite nanotubes (HNTs) as the enhancement center was added to the SPI and 1,2,3-propanetriol-diglycidyl-ether (PTGE) solution...
June 14, 2017: Materials
https://www.readbyqxmd.com/read/28772607/preparation-and-characterization-of-polyurethanes-with-cross-linked-siloxane-in-the-side-chain-by-sol-gel-reactions
#16
Hui Zhao, Tong-Hui Hao, Guo-Hua Hu, Dean Shi, Da Huang, Tao Jiang, Qun-Chao Zhang
A series of novel polyurethanes containing cross-linked siloxane in the side chain (SPU) were successfully synthesized through a sol-gel process. The SPU was composed of 0%-20% N-(n-butyl)-3-aminopropyltriethoxysilane (HDI-T) modified hexamethylene diisocynate homopolymer. The effects of HDI-T content on both the structure and properties of SPU were investigated by Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), mechanical properties tests, gel content test, water contact angle measurement and water absorption test...
February 28, 2017: Materials
https://www.readbyqxmd.com/read/28768847/cross-sectional-analysis-of-a-large-cohort-with-x-linked-charcot-marie-tooth-disease-cmtx1
#17
Francis B Panosyan, Matilde Laura, Alexander M Rossor, Chiara Pisciotta, Giuseppe Piscosquito, Joshua Burns, Jun Li, Sabrina W Yum, Richard A Lewis, John Day, Rita Horvath, David N Herrmann, Michael E Shy, Davide Pareyson, Mary M Reilly, Steven S Scherer
OBJECTIVE: To extend the phenotypic description of Charcot-Marie-Tooth disease (CMTX1) and to draw new genotype-phenotype relationships. METHODS: Mutations in GJB1 cause the main X-linked form of CMTX (CMTX1). We report cross-sectional data from 160 patients (from 120 different families, with 89 different mutations) seen at the Inherited Neuropathies Consortium centers. RESULTS: We evaluated 87 males who had a mean age of 41 years (range 10-78 years) and 73 females who had a mean age of 46 years (range 15-84 years)...
August 2, 2017: Neurology
https://www.readbyqxmd.com/read/28766134/bone-health-in-long-term-gastric-cancer-survivors-a-prospective-study-of-high-dose-vitamin-d-supplementation-using-an-easy-administration-scheme
#18
Marta Climent, Manuel Pera, Isabel Aymar, José M Ramón, Luis Grande, Xavier Nogués
Bone disease in long-term survivors after gastric cancer resection has received little research attention. This study aimed to investigate bone health after curative resection of gastric cancer and the consequences of high-dose vitamin D supplementation in patients with low levels of 25-(OH)-vitamin D. Disease-free patients at least 24 months after gastric cancer resection represented the study cohort. Serum markers of bone metabolism were assessed at baseline and at 3 and 12 months. Bone mineral density and presence of fractures were assessed by X-ray at baseline...
August 1, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28759640/t-dependent-b-cell-responses-to-plasmodium-induce-antibodies-that-form-a-high-avidity-multivalent-complex-with-the-circumsporozoite-protein
#19
Camilla R Fisher, Henry J Sutton, Joe A Kaczmarski, Hayley A McNamara, Ben Clifton, Joshua Mitchell, Yeping Cai, Johanna N Dups, Nicholas J D'Arcy, Mandeep Singh, Aaron Chuah, Thomas S Peat, Colin J Jackson, Ian A Cockburn
The repeat region of the Plasmodium falciparum circumsporozoite protein (CSP) is a major vaccine antigen because it can be targeted by parasite neutralizing antibodies; however, little is known about this interaction. We used isothermal titration calorimetry, X-ray crystallography and mutagenesis-validated modeling to analyze the binding of a murine neutralizing antibody to Plasmodium falciparum CSP. Strikingly, we found that the repeat region of CSP is bound by multiple antibodies. This repeating pattern allows multiple weak interactions of single FAB domains to accumulate and yield a complex with a dissociation constant in the low nM range...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28756317/sol-gel-3-glycidoxypropyltriethoxysilane-finishing-on-different-fabrics-the-role-of-precursor-concentration-and-catalyst-on-the-textile-performances-and-cytotoxic-activity
#20
M R Plutino, C Colleoni, I Donelli, G Freddi, E Guido, O Maschi, A Mezzi, G Rosace
In this paper, the influence of 3-glycidoxypropyltriethoxysilane (GPTES) based organic-inorganic coatings on the properties of treated textile fabrics was studied. All experimental results were deeply analyzed and thereafter correlated with the employed silica precursor concentration and with the presence of the BF3OEt2 (Boron trifluoride diethyl etherate), used as epoxy ring opening catalyst. SEM analysis, FT-IR spectroscopy, X-ray Photoelectron Spectroscopy (XPS), thermogravimetric analysis (TGA) and washing fastness tests of the sol-gel treated cotton fabric samples were firstly exploited in order to characterize the morphological and structural features of the achieved coatings...
July 18, 2017: Journal of Colloid and Interface Science
keyword
keyword
98023
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"