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https://www.readbyqxmd.com/read/27903361/-evaluation-of-health-effect-among-occupational-population-exposed-to-nano-titanium-dioxide-a-cross-sectional-study
#1
H D Xu, J W Zhou, S C Tang, F L Kong, X W Li, Z L Shen, L Yan, Z J Chen, L Zhao, G Jia, J Zhang
Objective: To characterize the health effects of nano-titanium dioxide exposure in an occupational cohort. Methods: Eighty-five male employees of a nano-titanium dioxide manufacturing enterprise in Shandong Province were evaluated in September 2014. Forty-four were exposed to nano-titanium dioxide (exposure group), and 41 were not exposed to nano-titanium dioxide (control group). We collected employees' basic information, smoking and drinking history, previous medical history, family history, and occupational history...
November 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27895039/region-specific-effect-of-the-decellularized-meniscus-extracellular-matrix-on-mesenchymal-stem-cell-based-meniscus-tissue-engineering
#2
Kazunori Shimomura, Benjamin B Rothrauff, Rocky S Tuan
BACKGROUND: The meniscus is the most commonly injured knee structure, and surgical repair is often ineffective. Tissue engineering-based repair or regeneration may provide a needed solution. Decellularized, tissue-derived extracellular matrices (ECMs) have received attention for their potential use as tissue-engineered scaffolds. In considering meniscus-derived ECMs (mECMs) for meniscus tissue engineering, it is noteworthy that the inner and outer regions of the meniscus have different structural and biochemical features, potentially directing the differentiation of cells toward region-specific phenotypes...
November 28, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27893850/a-convenient-in-vivo-model-using-small-interfering-rna-silencing-to-rapidly-assess-skeletal-gene-function
#3
Wen Zhang, Can Liu, Bao Hai, Guohong Du, Hong Wang, Huijie Leng, Yingsheng Xu, Chunli Song
It is difficult to study bone in vitro because it contains various cell types that engage in cross-talk. Bone biologically links various organs, and it has thus become increasingly evident that skeletal physiology must be studied in an integrative manner in an intact animal. We developed a model using local intraosseous small interfering RNA (siRNA) injection to rapidly assess the effects of a target gene on the local skeletal environment. In this model, 160-g male Sprague-Dawley rats were treated for 1-2 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/27892671/association-between-the-xrcc3-thr241met-polymorphism-and-gastrointestinal-cancer-risk-a-meta-analysis
#4
Mohammad Hossein Sahami-Fard, Ali Reza Mousa Mayali, Ahmad Tajehmiri
Background: The x-ray repair cross-complementing group 3 (XRCC3) encodes a protein involved in the homologous recombination repair (HRR) pathway for double-strand DNA repair. Associations of the XRCC3 Thr241Met polymorphism with various cancers have been widely reported. However, published data on links between XRCC3 Thr241Met and gastrointestinal (GI) cancer risk are inconsistent. Objective and Methods: A meta-analysis was conducted to characterize the relationship between XRCC3 Thr241Met polymorphisms and GI cancer risk...
January 10, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27877070/aerobic-power-and-lean-mass-are-indicators-of-competitive-sprint-performance-among-elite-female-cross-country-skiers
#5
Tomas Carlsson, Michail Tonkonogi, Magnus Carlsson
The purpose of this study was to establish the optimal allometric models to predict International Ski Federation's ski-ranking points for sprint competitions (FISsprint) among elite female cross-country skiers based on maximal oxygen uptake ( [Formula: see text]) and lean mass (LM). Ten elite female cross-country skiers (age: 24.5±2.8 years [mean ± SD]) completed a treadmill roller-skiing test to determine [Formula: see text] (ie, aerobic power) using the diagonal stride technique, whereas LM (ie, a surrogate indicator of anaerobic capacity) was determined by dual-emission X-ray anthropometry...
2016: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/27873076/the-association-of-testosterone-sex-hormone-binding-globulin-and-insulin-like-growth-factor-1-with-bone-parameters-in-korean-men-aged-50%C3%A2-years-or-older
#6
Hye-Jung Kim, Hyung Suk Koo, Young-Sang Kim, Moon Jong Kim, Kwang-Min Kim, Nam-Seok Joo, Ji-Hee Haam
Testosterone and insulin-like growth factor-1 (IGF-1) are essential factors for the maintenance of bone health in men. However, the results for the association of testosterone and IGF-1 with bone parameters were not consistent in prior studies. We evaluated the relationship of testosterone, sex hormone-binding globulin (SHBG), and IGF-1 with bone mineral density (BMD) and bone turnover markers (BTMs) in Korean men. We enrolled 1227 men aged ≥50 years in this cross-sectional study. Serum levels of total testosterone (TT), SHBG, IGF-1, osteocalcin, and C-terminal cross-linking telopeptide of type I collagen (CTX) were measured...
November 21, 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27873074/a-cross-sectional-study-of-the-association-between-adipokine-levels-and-bone-mineral-density-according-to-obesity-and-menopausal-status-in-korean-women
#7
Ji-Hee Haam, Young-Sang Kim, Moon Jong Kim, Hyung Suk Koo, Hyung Yuk Kim, Hye-Jung Kim, Ki Hyun Park, Nam-Seok Joo, Kyung-Chae Park
Results regarding the association between adipokine levels and bone mineral density (BMD) have been inconsistent; the effects of sex, menopause, and central obesity remain unknown. We evaluated the association between serum leptin, adiponectin, and high-molecular-weight (HMW) adiponectin levels and BMD according to menopause and central obesity status in Korean women. This cross-sectional study comprised 255 women undergoing examinations at the CHA Bundang Medical Center. Participants were divided according to menopause, and central obesity status...
November 21, 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27851980/co-delivery-of-zinc-and-5-aminosalicylic-acid-from-alginate-n-succinyl-chitosan-blend-microspheres-for-synergistic-therapy-of-colitis
#8
Haogang Duan, Shaoyu Lü, Hongyan Qin, Chunmei Gao, Xiao Bai, Yuhui Wei, Xin'an Wu, Mingzhu Liu, Xinyu Zhang, Zhen Liu
The present study developed novel zinc ion cross-linked alginate/N-succinyl-chitosan (NSC) blend microspheres (MS) for co-delivery of zinc and 5-aminosalicylic acid (5-ASA) for synergistic therapy of colitis. Physicochemical characterization of blend MS was assessed using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and energy dispersive X-ray spectrometer (EDS). In vitro release studies demonstrated that blend MS has a pH-dependent release property. Both 5-ASA and zinc have lower release in acid medium and higher release in colonic environment...
November 13, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27835738/leukocyte-telomere-length-effects-of-schizophrenia-age-and-gender
#9
Owen M Wolkowitz, Dilip V Jeste, Averria Sirkin Martin, Jue Lin, Rebecca E Daly, Chase Reuter, Helena Kraemer
BACKGROUND: Schizophrenia is linked with early medical comorbidity and mortality. These observations indicate possible "accelerated biological aging" in schizophrenia, although prior findings are mixed, and few such studies have examined the role of gender. One putative marker of biological aging is leukocyte telomere length (LTL), which typically shortens with age. METHODS: We assessed LTL in phenotypically well characterized 134 individuals with schizophrenia (60 women and 74 men) and 123 healthy comparison subjects (HCs) (66 women and 57 men), aged 26 to 65 years...
October 20, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27822910/organic-inorganic-nano-hybrids-with-high-dielectric-constant-for-organic-thin-film-transistor-applications
#10
Yang-Yen Yu, Ai-Hua Jiang, Wen-Ya Lee
The organic material soluble polyimide (PI) and organic-inorganic hybrid PI-barium titanate (BaTiO3) nanoparticle dielectric materials (IBX, where X is the concentration of BaTiO3 nanoparticles in a PI matrix) were successfully synthesized through a sol-gel process. The effects of various BaTiO3 contents on the hybrid film performance and performance optimization were investigated. Furthermore, pentacene-based organic thin film transistors (OTFTs) with PI-BaTiO3/polymethylmethacrylate or cyclic olefin copolymer (COC)-modified gate dielectrics were fabricated and examined...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27818009/use-of-the-six-minute-walk-test-to-characterize-golden-retriever-muscular-dystrophy
#11
Austin R Acosta, Emiko Van Wie, William B Stoughton, Amanda K Bettis, Heather H Barnett, Nicholas R LaBrie, Cynthia J Balog-Alvarez, Peter P Nghiem, Kevin J Cummings, Joe N Kornegay
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder in which loss of the dystrophin protein causes progressive skeletal/cardiac muscle degeneration and death within the third decade. For clinical trials and supportive animal studies, DMD disease progression and response to treatment must be established using outcome parameters (biomarkers). The 6-minute walk test (6MWT), defined as the distance an individual can walk in 6 minutes, is commonly used in DMD clinical trials and has been employed in dogs to characterize cardiac and respiratory disease severity...
October 3, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/27806112/the-clinical-and-biochemical-predictors-of-bone-mass-in-preterm-infants
#12
Justyna Czech-Kowalska, Edyta Czekuc-Kryskiewicz, Pawel Pludowski, Katarzyna Zaniuk, Maciej Jaworski, Anna Łuba, Karolina Grzybowska, Krystyna Piłat, Anna Dobrzanska
BACKGROUND: Metabolic bone disease of prematurity still occurs in preterm infants, although a significant improvement in neonatal care has been observed in recent decades. Dual-energy X-ray absorptiometry (DXA) is the precise technique for assessing bone mineral content (BMC) in preterm infants, but is not widely available. AIM: To investigate the clinical and biochemical parameters, including bone metabolism markers as potential predictors of BMC, in preterm infants up to 3 months corrected age (CA)...
2016: PloS One
https://www.readbyqxmd.com/read/27805763/superparamagnetic-composites-based-on-ionic-resin-beads-caco3-magnetite
#13
Ion Bunia, Vlad Socoliuc, Ladislau Vekas, Florica Doroftei, Cristian Varganici, Adina Coroaba, Bogdan C Simionescu, Marcela Mihai
The preparation of superparamagnetic composites obtained by CaCO3 mineralization from supersaturate aqueous solutions is presented. The preparation was conducted in the presence of oleic acid stabilized magnetite nanoparticles as a water-based magnetic fluid and insoluble templates as gel-like cross-linked polymeric beads. The presence of the magnetic particles in the composites provides a facile way for external manipulation using a permanent magnet, thus allowing the separation and extraction of magnetically modified materials...
November 2, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27796090/fluorescence-probe-based-on-amino-functionalized-fluorescent-magnetic-nanocomposite-for-detection-of-folic-acid-in-serum
#14
Xiaowan Li, Ligang Chen
A new fluorescence probe constructed with a multifunctional nanocomposite, Fe3O4-ZnS:Mn2+/SiO2-NH2, was successfully synthesized and then used to detect folic acid in real serum samples. The nanocomposite was characterized by fluorescence spectroscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray powder diffraction and physical property measurement system. With the addition of analyte, the Fe3O4-ZnS:Mn2+/SiO2-NH2 composite and folic acid formed a new complex because cross-linking of the amino and carboxyl groups participated in the condensation reaction...
October 31, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27788681/native-t1-values-identify-myocardial-changes-and-stratify-disease-severity-in-patients-with-duchenne-muscular-dystrophy
#15
Laura J Olivieri, Peter Kellman, Robert J McCarter, Russell R Cross, Michael S Hansen, Christopher F Spurney
BACKGROUND: Duchenne muscular dystrophy (DMD) is an X-linked, inherited disorder causing dilated cardiomyopathy with variable onset and progression. Currently we lack objective markers of the effect of therapies targeted towards preventing progression of subclinical cardiac disease. Thus, our aim was to compare the ability of native T1 and extracellular volume (ECV) measurements to differentiate risk of myocardial disease in DMD and controls. METHODS: Twenty boys with DMD and 16 age/gender-matched controls without history predisposing to cardiac fibrosis, but with a clinical indication for cardiovascular magnetic resonance (CMR) evaluation, underwent CMR with contrast...
October 28, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27770895/effects-of-halloysite-nanotubes-on-physical-properties-and-cytocompatibility-of-alginate-composite-hydrogels
#16
Biao Huang, Mingxian Liu, Zheru Long, Yan Shen, Changren Zhou
Sodium alginate (SA)/halloysite nanotubes (HNTs) composite hydrogels were successfully prepared by solution blending and cross-linking with calcium ions. HNTs can improve the physical properties and cytocompatibility of composite hydrogels. The static and shear viscosity of SA/HNTs solution increase by the addition of HNTs. FTIR suggests the presence of hydrogen bond interactions between HNTs and SA. The crystal structure of HNTs is retained in the composites as showed by the X-ray diffraction result. A porous structure with pore size of 100-250μm is found in the hydrogels, which can provide a space for cell growth and migration...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27768520/synthesis-of-magnetic-epichlorohydrin-cross-linked-carboxymethyl-cellulose-microspheres-and-their-adsorption-behavior-for-methylene-blue
#17
Qingwen Lin, Jiali Chang, Mengfan Gao, Hongzhu Ma
Epichlorohydrin cross-linked carboxymethyl cellulose microspheres (ECH/CMC) obtained by inverse suspension method and magnetic Fe3O4 nanoparticles encasing the ECH/CMC microspheres (M-ECH/CMC) obtained by two different methods were successfully prepared and compared. Their structures and morphologies were analyzed using polarizing microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction. The adsorption behaviors of M1-ECH/CMC for methylene blue (MB) in the single cationic dye wastewater, the cationic/anionic dye mixture in the absence or presence of co-existed additives (salt and surfactant) wastewater, were also investigated with UV-vis spectrometer...
October 21, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27766589/assessment-of-distal-radius-bone-mineral-density-in-osteoporosis-patients-receiving-denosumab-including-those-with-rheumatoid-arthritis-and-those-receiving-oral-glucocorticoids
#18
Hiroaki Matsuno
BACKGROUND AND OBJECTIVES: Recently, the osteoporosis treatment has attracted attention, and several drugs have been developed. Among these, bisphosphonates (BPs), parathyroid hormone (PTH) and anti-receptor activator of nuclear factor kappa B ligand (RANKL) monoclonal (MAb) denosumab (DMAb) are the major osteoporosis agents. Several studies demonstrated that the effect of osteoporosis agents is evaluated by lumar or hip dual energy X-ray absorptiometry (DXA). However, private clinic commonly use the radial DXA...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27766367/increased-levels-of-dickkopf-1-are-indicative-of-wnt-%C3%AE-catenin-downregulation-and-lower-osteoblast-signaling-in-children-and-adolescents-with-type-1-diabetes-mellitus-contributing-to-lower-bone-mineral-density
#19
C Tsentidis, D Gourgiotis, L Kossiva, A Marmarinos, A Doulgeraki, K Karavanaki
: Higher levels of Dickkopf-1, which is an inhibitor of Wnt/β-catenin bone metabolic pathway, could be indicative of downregulated Wnt system, with possible lower osteoblast activation and higher osteoclast signaling in type 1 diabetes mellitus children and adolescents. Dickkopf-1 could significantly contribute to diabetes osteopathy. INTRODUCTION: Increased fracture risk and elevated Dickkopf-1 levels, which is an inhibitor of Wnt/β-catenin bone metabolic pathway, have been documented in adult patients with type 2 diabetes mellitus (T2D), while no relevant data exist on childhood type 1 diabetes (T1D)...
October 20, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27765264/physicochemical-properties-and-micro-structural-characteristics-in-starch-from-kudzu-root-as-affected-by-cross-linking
#20
Boru Chen, Leping Dang, Xiao Zhang, Wenzhi Fang, Mengna Hou, Tiankuo Liu, Zhanzhong Wang
Kudzu starch was cross-linked with sodium trimetaphosphate (STMP) at different temperatures, time and of STMP concentrations in this work. The cross-linked starches (CLSs) were fractionated further into cross-linked amylose and amylopectin in order to compare the effect of cross-linking on the microstructure. According to scanning electron microscope (SEM), CLSs displayed the resemble appearance of spherical and polygonal shapes like NS. X-ray diffraction (XRD) revealed that amylose of native starch (A), NS and CLS displayed a combination of A-type and B-type structure, while that was not found in amylose of cross-linked starch (CLA)...
March 15, 2017: Food Chemistry
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