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https://www.readbyqxmd.com/read/28443265/registration-for-deceased-organ-and-tissue-donation-among-ontario-immigrants-a-population-based-cross-sectional-study
#1
Alvin Ho-Ting Li, Ngan N Lam, Sonny Dhanani, Matthew Weir, Versha Prakash, Joseph Kim, Greg Knoll, Amit X Garg
BACKGROUND: Canada has low rates of deceased organ and tissue donation. Immigrants to Canada may differ in their registered support for deceased organ donation based on their country of origin. METHODS: We used linked administrative databases in Ontario (about 11 million residents aged ≥ 16 yr) to study the proportion of immigrants and long-term residents registered for deceased organ and tissue donation as of October 2013. We used modified Poisson regression to identify and quantify predictors of donor registration...
October 2016: CMAJ Open
https://www.readbyqxmd.com/read/28422549/obesity-is-associated-with-altered-plantar-pressure-distribution-in-elderly-women
#2
Silvia Gonçalves Ricci Neri, André Bonadias Gadelha, Ana Luiza Matias Correia, Juscélia Cristina Pereira, Ana Cristina de David, Ricardo Moreno Lima
Increased plantar pressure has been found to be related with greater risk of falling. Although there is evidence suggesting that obesity is linked to foot disorders, the association between obesity and plantar pressure of older adults has been poorly investigated. The purpose of this study was to examine the association between obesity and plantar pressure distribution and to explore its relationship with body fat distribution. Two hundred and eleven elderly women took part in this cross-sectional study. Body mass index were taken for obesity classification...
April 19, 2017: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/28419926/stability-and-activity-of-immobilized-trypsin-on-carboxymethyl-chitosan-functionalized-magnetic-nanoparticles-cross-linked-with-carbodiimide-and-glutaraldehyde
#3
Jun Sun, Lin Yang, Mengmeng Jiang, Yu Shi, Bin Xu, Hai-le Ma
Enzyme cross-linkers, such as 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and glutaraldehyde (GA), have been used to improve the stability of immobilized enzymes. We have developed a relatively stable and high-activity immobilized trypsin through EDC and GA cross-linking. Carboxymethyl chitosan (CM-CTS)-functionalized magnetic nanoparticles (Fe3O4@CM-CTS) were prepared, and characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis, X-ray diffraction, and transmission electron microscopy...
April 10, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28399281/potential-roles-of-pigs-small-ruminants-rodents-and-their-flea-vectors-in-plague-epidemiology-in-sinda-district-eastern-zambia
#4
Stanley S Nyirenda, Bernard M Hang'ombe, Bukheti S Kilonzo, Henry L Kangwa, Evans Mulenga, Ladslav Moonga
A cross-sectional study was conducted in the Eastern part of Zambia that previously reported a plague outbreak. The aim of the study was to evaluate the potential role of pigs, goats, and sheep as sero-surveillance hosts for monitoring plague, and to investigate the flea vectors and potential reservoir hosts to establish the current status of plague endemicity in the district. Serum samples were collected from 96 rodents, 10 shrews, 245 domestic pigs, 232 goats, and 31 sheep, whereas 106 organs were eviscerated from rodents and shrews...
February 4, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28397459/assessment-of-the-link-between-xrcc1-arg399gln-polymorphism-and-breast-cancer-a-meta-analysis-in-a-single-ethnic-group
#5
Xin-Ping Chen, Hai-Feng Wen, Fan Zhang, Wei-Hua Xu, Zhi-Chao Ma, Sheng-Miao Fu
BACKGROUND: Although various individual studies have been conducted to determine the association between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism and breast cancer, the results remain inconclusive. To assess the influence of XRCC1 Arg399Gln polymorphism on the risk of breast cancer, a metaanalysis was performed in a single ethnic group. METHODS: Eligible studies were identified via databases such as PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine, throughout February 2016...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28396397/dimerization-of-tie2-mediated-by-its-membrane-proximal-fniii-domains
#6
Jason O Moore, Mark A Lemmon, Kathryn M Ferguson
Tie1 and Tie2, members of the tyrosine kinase family with immunoglobulin and EGF homology domains, are receptor tyrosine kinases found primarily in endothelial cells with key roles in development and maintenance of the vasculature and in angiogenesis. They are attractive targets for therapeutic intervention in tumor angiogenesis, inflammation, and sepsis. Tie2 is regulated directly by the multimeric angiopoietin (Ang) ligands, with Ang1 being its primary activator. Structural studies have shown how Angs bind to the Tie2 ligand-binding region, but do not explain Tie2 activation and suggest a passive role for the Tie2 extracellular region (ECR) in ligand-induced receptor dimerization...
April 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28394585/compound-copper-chalcogenide-nanocrystals
#7
Claudia Coughlan, Maria Ibáñez, Oleksandr Dobrozhan, Ajay Singh, Andreu Cabot, Kevin M Ryan
This review captures the synthesis, assembly, properties, and applications of copper chalcogenide NCs, which have achieved significant research interest in the last decade due to their compositional and structural versatility. The outstanding functional properties of these materials stems from the relationship between their band structure and defect concentration, including charge carrier concentration and electronic conductivity character, which consequently affects their optoelectronic, optical, and plasmonic properties...
April 10, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28391848/poly-2-methyl-2-oxazoline-coating-by-thermally-induced-immobilization-for-determination-of-bovine-lactoferrin-in-infant-formula-with-capillary-electrophoresis
#8
Ke Mao, Haiqin Du, Longchao Bai, Yalin Zhang, Haikun Zhu, Yanmei Wang
In this work, a one-step coating procedure by a simple annealing protocol of poly (2-methyl-2-oxazoline)-random-glycidyl methacrylate (PMOXA-r-GMA) copolymer was used to yield covalent and cross-linked PMOXA-based antifouling coating on a fused-silica capillary inner surface, which was used to determine the bovine lactoferrin (Lf) in infant formula by capillary electrophoresis with ultraviolet (CE-UV) detection. The X-ray photoelectron spectroscopy (XPS) confirmed that PMOXA-r-GMA could be bonded onto fused-silica capillary inner wall and stable electroosmotic flow (EOF) was obtained in the PMOXA-r-GMA coated capillary at pH 2...
June 1, 2017: Talanta
https://www.readbyqxmd.com/read/28391319/allele-specific-expression-analysis-does-not-support-sex-chromosome-inactivation-on-the-chicken-z-chromosome
#9
Qiong Wang, Judith E Mank, Junying Li, Ning Yang, Lujiang Qu
Heterogametic sex chromosomes have evolved many times independently, and in many cases, the loss of functional genes from the sex-limited Y or W chromosome leaves only one functional gene copy on the corresponding X or Z chromosome in the heterogametic sex. Because gene dose often correlates with gene expression level, this difference in gene dose between males and females for X- or Z-linked genes in some cases has selected for chromosome-wide transcriptional dosage compensation mechanisms to counteract any reduction in expression in the heterogametic sex...
March 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28391259/new-concept-of-x-ray-repair-cross-complementing-groups-1-polymorphisms-and-gynecologic-cancer-risk
#10
Yali Du, Huifang Wang, Bei Lv
BACKGROUND: Several meta-analyses have been conducted to examine the possible link between X-ray repair cross-complementing groups 1 (XRCC1) Arg399Gln polymorphism and cervical cancer risk. However, the results are controversial. Therefore, we carried out a more comprehensive meta-analysis to examine whether XRCC1 polymorphisms are associated with general gynecologic cancer risk. METHODS: Twenty studies, comprising 4,230 cases and 5,458 controls that included analyses of XRCC1 polymorphisms (Arg194Trp, Arg280His, or Arg399Gln) were included in our study...
April 8, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28372558/fatty-acid-composition-in-serum-cholesterol-esters-and-phospholipids-is-linked-to-visceral-and-subcutaneous-adipose-tissue-content-in-elderly-individuals-a-cross-sectional-study
#11
Fredrik Rosqvist, Helena Bjermo, Joel Kullberg, Lars Johansson, Karl Michaëlsson, Håkan Ahlström, Lars Lind, Ulf Risérus
BACKGROUND: Visceral adipose tissue (VAT) and truncal fat predict cardiometabolic disease. Intervention trials suggest that saturated fatty acids (SFA), e.g. palmitic acid, promote abdominal and liver fat storage whereas polyunsaturated fatty acids (PUFA), e.g. linoleic acid, prevent fat accumulation. Such findings require investigation in population-based studies of older individuals. We aimed to investigate the relationships of serum biomarkers of PUFA intake as well as serum levels of palmitic acid, with abdominal and total adipose tissue content...
April 4, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28368598/structural-and-topological-evolution-in-sixse1-x-glasses-results-from-1d-and-2d-29-si-and-77-se-nmr-spectroscopy
#12
M A T Marple, I Hung, Z Gan, S Sen
The coordination environments of Si and Se atoms and their connectivity in binary SixSe1-x glasses with 0.05 ≤ x ≤ 0.33 are investigated using a combination of one- and two-dimensional (29)Si and (77)Se nuclear magnetic resonance (NMR) and Raman spectroscopy. The high-resolution correlated isotropic and anisotropic (29)Si and (77)Se NMR spectra allow for the identification and quantitation of a variety of Si and Se environments. The results suggest that the structure of these glasses are characterized by a network with essentially perfect short-range chemical order, but with strong clustering at the intermediate range...
April 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28362954/chronic-granulomatous-disease-in-patients-reaching-adulthood-a-nationwide-study-in-france
#13
Bertrand Dunogué, Benoit Pilmis, Nizar Mahlaoui, Caroline Elie, Hélène Coignard-Biehler, Karima Amazzough, Nicolas Noël, Hélène Salvator, Emilie Catherinot, Louis-Jean Couderc, Harry Sokol, Fanny Lanternier, Fanny Fouyssac, Julie Bardet, Jacinta Bustamante, Marie-Anne Gougerot-Pocidalo, Vincent Barlogis, Agathe Masseau, Isabelle Durieu, Marc Lecuit, Felipe Suarez, Alain Fischer, Stéphane Blanche, Olivier Hermine, Olivier Lortholary
Background: Although prognosis of Chronic Granulomatous Disease (CGD) has greatly improved, few studies have focused on its long-term outcome. We studied the clinical course and sequelae of CGD patients diagnosed before age 16, at various adult time points. Method: Cross-sectional French nationwide retrospective study of patients screened through the National Reference Center for Primary Immunodeficiencies (CEREDIH) registry. Results: Eighty CGD patients (71 males [88...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28356426/whole-grain-intake-reflected-by-dietary-records-and-biomarkers-is-inversely-associated-with-circulating-insulin-and-other-cardiometabolic-markers-in-8-to-11-year-old-children
#14
Camilla T Damsgaard, Anja Biltoft-Jensen, Inge Tetens, Kim F Michaelsen, Mads V Lind, Arne Astrup, Rikard Landberg
Background: Whole-grain consumption seems to be cardioprotective in adults, but evidence in children is limited.Objective: We investigated whether intakes of total whole grain and dietary fiber as well as specific whole grains were associated with fat mass and cardiometabolic risk profile in children.Methods: We collected cross-sectional data on parental education, puberty, diet by 7-d records, and physical activity by accelerometry and measured anthropometry, fat mass index by dual-energy X-ray absorptiometry, and blood pressure in 713 Danish children aged 8-11 y...
March 29, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28352524/immobilization-of-%C3%AF-transaminase-by-magnetic-pva-fe3o4-nanoparticles
#15
Honghua Jia, Fan Huang, Zhen Gao, Chao Zhong, Hua Zhou, Min Jiang, Ping Wei
ω-Transaminase (ω-TA) as a kind of important biocatalyst is widely used in preparation of chiral intermediates. In this paper, a magnetic PVA-Fe3O4 nanoparticles was prepared and employed on immobilization of ω-TA to reduce the cost, increase reusability and enhance stability. The prepared magnetic PVA-Fe3O4 nanoparticles were characterized by transmission electron microscope (TEM), X-ray diffraction (XRD) and vibrating sample magnetometer (VSM). The average size of magnetic PVA-Fe3O4 nanoparticles was located between 30-40 nm ω-TA was immobilized onto magnetic PVA-Fe3O4 nanoparticles via glutaraldehyde cross-linking, achieving a wider pH range as 6-8 and also a better thermal stability at 60 °C...
June 2016: Biotechnology Reports
https://www.readbyqxmd.com/read/28346376/blend-hydrogel-microspheres-of-carboxymethyl-chitosan-and-gelatin-for-the-controlled-release-of-5-fluorouracil
#16
Vanarchi Rajini Kanth, Praveen B Kajjari, Priya M Madalageri, Sakey Ravindra, Lata S Manjeshwar, Tejraj M Aminabhavi
Carboxymethyl chitosan (CMCS) was synthesized and blended with gelatin (GE) to prepare hydrogel microspheres by w/o emulsion cross-linking in the presence of glutaraldehyde (GA), which acted as a cross-linker. 5-Fluorouracil (5-FU) was encapsulated to investigate its controlled release (CR) characteristics in acidic (pH 1.2) and alkaline (pH 7.4) buffer media. The microspheres which formed were spherical in nature, with smooth surfaces, as judged by the scanning electron microscopy (SEM). Fourier transform infrared spectroscopy (FTIR) confirmed the carboxymethylation of CS and the chemical stability of 5-FU in the formulations...
March 27, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28341762/a-prospective-observational-study-on-effect-of-short-term-periodic-steroid-premedication-on-bone-metabolism-in-gastrointestinal-cancer-espresso-01
#17
Michio Nakamura, Atsushi Ishiguro, Tetsuhito Muranaka, Hiraku Fukushima, Satoshi Yuki, Kota Ono, Taichi Murai, Chika Matsuda, Ayane Oba, Kazufumi Itaya, Takayuki Sone, Masataka Yagisawa, Yuta Koike, Ayana Endo, Yoko Tsukuda, Yuji Ono, Takahiko Kudo, Atsushi Nagasaka, Shuji Nishikawa, Yoshito Komatsu
BACKGROUND: A multicenter prospective observational study evaluated the effect of gastrointestinal cancer chemotherapy with short-term periodic steroid premedication on bone metabolism. PATIENTS AND METHODS: Seventy-four patients undergoing chemotherapy for gastrointestinal cancer were studied. The primary endpoints were changes in bone mineral densities (BMDs) and metabolic bone turnover 16 weeks after initiation of chemotherapy. BMDs, measured by dual-energy x-ray absorptiometry, and serum cross-linked N-telopeptides of type I collagen (sNTX), and bone alkaline phosphatase (sBAP) were assessed for evaluation of bone resorption and formation, respectively...
March 24, 2017: Oncologist
https://www.readbyqxmd.com/read/28340533/vapor-phase-exchange-of-self-assembled-monolayers-for-engineering-of-biofunctional-surfaces
#18
L Kankate, A Aguf, H Großmann, M Schnietz, R Tampé, A Turchanin, A Gölzhäuser
We show that 4'-nitro-1,1'-biphenyl-4-thiol self-assembled monolayers (NBPT SAMs) on gold can be exchanged with 11-(mercaptoundecyl)triethylene glycol (C11EG3OH) SAMs via vapor deposition (VD). The pristine and the exchanged SAMs obtained by VD as well as solution method (SM) were characterized by X-ray photoelectron spectroscopy (XPS) and polarization modulation infrared reflection-absorption spectroscopy (PM-IRRAS). Using surface plasmon resonance (SPR), it is shown that C11EG3OH SAMs on gold obtained by vapor deposition exchange (VDEx) have the same protein resistivity as SAMs obtained by the direct self-assembly process...
April 3, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28336222/evaluation-of-the-shifting-of-the-line-of-sight-and-higher-order-aberrations-of-eyes-with-keratoconus-after-corneal-cross-linking
#19
Pinar Kosekahya, Mustafa Koc, Kemal Tekin, Murat Uzel, Cemile Ucgul Atilgan, Mehtap Caglayan, Pelin Yilmazbas
AIM: To evaluate changes in the coordinates of the line of sight (LoS) and higher order aberrations (HOAs) of eyes with keratoconus, following corneal cross-linking (CXL). METHODS: All patients (93 eyes) underwent detailed ophthalmologic examination and Pentacam HR measurements at baseline and at 3, 6, and 12 months after corneal CXL. LoS coordinates on the horizontal (x) and vertical (y) axes, vertical coma, vertical trefoil, spherical aberration, total root-mean square (RMS), and HOA-RMS values were recorded along with visual acuity and topographical parameters...
March 20, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28334953/early-motor-phenotype-detection-in-a-female-mouse-model-of-rett-syndrome-is-improved-by-cross-fostering
#20
Annie Vogel Ciernia, Michael Pride, Blythe Durbin-Johnson, Adriana Noronha, Alene Chang, Dag H Yasui, Jacqueline N Crawley, Janine M LaSalle
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the gene encoding methyl CpG binding protein 2 (MeCP2) that occur sporadically in 1:10,000 female births. RTT is characterized by a period of largely normal development followed by regression in language and motor skills at 6-18 months of age. Mecp2 mutant mice recapitulate many of the clinical features of RTT, but the majority of behavioral assessments have been conducted in male Mecp2 hemizygous null mice as offspring of heterozygous dams...
March 11, 2017: Human Molecular Genetics
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