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Influenza challenge studies

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https://www.readbyqxmd.com/read/28429728/a-formulated-tlr7-8-agonist-is-a-flexible-highly-potent-and-effective-adjuvant-for-pandemic-influenza-vaccines
#1
Neal Van Hoeven, Christopher B Fox, Brian Granger, Tara Evers, Sharvari W Joshi, Ghislain I Nana, Sarah C Evans, Susan Lin, Hong Liang, Li Liang, Rie Nakajima, Philip L Felgner, Richard A Bowen, Nicole Marlenee, Airn Hartwig, Susan L Baldwin, Rhea N Coler, Mark Tomai, James Elvecrog, Steven G Reed, Darrick Carter
Since 1997, highly pathogenic avian influenza viruses of the H5N1 subtype have been transmitted from avian hosts to humans. The severity of H5N1 infection in humans, as well as the sporadic nature of H5N1 outbreaks, both geographically and temporally, make generation of an effective vaccine a global public health priority. An effective H5N1 vaccine must ultimately provide protection against viruses from diverse clades. Toll-like receptor (TLR) agonist adjuvant formulations have a demonstrated ability to broaden H5N1 vaccine responses in pre-clinical models...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28424887/a-metagenomics-study-for-the-identification-of-respiratory-viruses-in-mixed-clinical-specimens-an-application-of-the-iterative-mapping-approach
#2
Yu-Nong Gong, Shu-Li Yang, Guang-Wu Chen, Yu-Wen Chen, Yhu-Chering Huang, Hsiao-Chen Ning, Kuo-Chien Tsao
Metagenomic approaches to detect viral genomes and variants in clinical samples have various challenges, including low viral titers and bacterial and human genome contamination. To address these limitations, we examined a next-generation sequencing (NGS) and iterative mapping approach for virus detection in clinical samples. We analyzed 40 clinical specimens from hospitalized children diagnosed with acute bronchiolitis, croup, or respiratory tract infections in which virus identification by viral culture or polymerase chain reaction (PCR) was unsuccessful...
April 19, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28424686/mucosal-and-systemic-immune-responses-to-influenza-h7n9-antigen-ha1-2-co-delivered-intranasally-with-flagellin-or-polyethyleneimine-in-mice-and-chickens
#3
Li Song, Dan Xiong, Hongqin Song, Lili Wu, Meihua Zhang, Xilong Kang, Zhiming Pan, Xinan Jiao
Consecutive cases of human infection with H7N9 influenza viruses since 2013 in China have prompted efforts to develop an effective treatment. Subunit vaccines introduced by intranasal administration can block an infection at its primary site; flagellin (fliC) and polyethyleneimine (PEI) have been shown to be potent adjuvants. We previously generated the hemagglutinin (HA)1-2-fliC fusion protein consisting of the globular head domain (HA1-2; amino acids 62-284) of HA fused with Salmonella typhimurium fliC. In the present study, we investigated its effectiveness of both flagellin and PEI as mucosal adjuvants for the H7N9 influenza subunit vaccine...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28424239/aim2-inflammasome-is-critical-for-influenza-induced-lung-injury-and-mortality
#4
Hongbo Zhang, Jiadi Luo, John F Alcorn, Kong Chen, Songqing Fan, Joseph Pilewski, Aizhong Liu, Wei Chen, Jay K Kolls, Jieru Wang
The absent in melanoma 2 (AIM2) inflammasome plays an important role in many viral and bacterial infections, but very little is known about its role in RNA virus infection, including influenza A virus (IAV). In this study, we have designed in vivo and in vitro studies to determine the role of AIM2 in infections with lethal doses of IAVs A/PR8/34 and A/California/07/09. In wild-type mice, IAV infection enhanced AIM2 expression, induced dsDNA release, and stimulated caspase-1 activation and release of cleaved IL-1β in the lung, which was significantly reduced in AIM2-deficient mice...
April 19, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28422149/monitoring-seasonal-influenza-epidemics-by-using-internet-search-data-with-an-ensemble-penalized-regression-model
#5
Pi Guo, Jianjun Zhang, Li Wang, Shaoyi Yang, Ganfeng Luo, Changyu Deng, Ye Wen, Qingying Zhang
Seasonal influenza epidemics cause serious public health problems in China. Search queries-based surveillance was recently proposed to complement traditional monitoring approaches of influenza epidemics. However, developing robust techniques of search query selection and enhancing predictability for influenza epidemics remains a challenge. This study aimed to develop a novel ensemble framework to improve penalized regression models for detecting influenza epidemics by using Baidu search engine query data from China...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28422004/performance-of-influenza-case-definitions-for-influenza-community-surveillance-based-on-the-french-influenza-surveillance-network-grog-2009-2014
#6
Jean-Sebastien Casalegno, Daniel Eibach, Martine Valette, Vincent Enouf, Isabelle Daviaud, Sylvie Behillil, Astrid Vabret, Jean Claude Soulary, Mehdi Benchaib, Jean Marie Cohen, Sylvie van der Werf, Anne Mosnier, Bruno Lina
International case definitions recommended by the Centers for Disease Control and Prevention (CDC), the European Centre for Disease Prevention and Control (ECDC), and the World Health Organization (WHO) are commonly used for influenza surveillance. We evaluated clinical factors associated with the laboratory-confirmed diagnosis of influenza and the performance of these influenza case definitions by using a complete dataset of 14,994 patients with acute respiratory infection (ARI) from whom a specimen was collected between August 2009 and April 2014 by the Groupes Régionaux d'Observation de la Grippe (GROG), a French national influenza surveillance network...
April 6, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28418904/a-consensus-hemagglutinin-based-vaccine-delivered-by-an-attenuated-salmonella-mutant-protects-chickens-against-heterologous-h7n1-influenza-virus
#7
Kim Je Hyoung, Irshad Ahmed Hajam, John Hwa Lee
H7N3 and H7N7 are highly pathogenic avian influenza (HPAI) viruses and have posed a great threat not only for the poultry industry but for the human health as well. H7N9, a low pathogenic avian influenza (LPAI) virus, is also highly pathogenic to humans, and there is a great concern that these H7 subtypes would acquire the ability to spread efficiently between humans, thereby becoming a pandemic threat. A vaccine candidate covering all the three subtypes must, therefore, be an integral part of any pandemic preparedness plan...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417679/synergy-or-interference-of-a-h9n2-avian-influenza-virus-with-a-velogenic-newcastle-disease-virus-in-chickens-are-dose-dependent
#8
Francesco Bonfante, Giovanni Cattoli, Sofia Leardini, Angela Salomoni, Eva Mazzetto, Irit Davidson, Ruth Haddas, Calogero Terregino
Field observations indicate that the impact of velogenic Newcastle disease virus (vNDV) is more severe in countries with concomitant circulation of LPAI virus, as is the case in the Middle East, in particular in Israel, where H9N2 and NDV are endemic. In our study, we evaluated how the exposure of chickens to a H9N2 challenge either favors or interferes with a subsequent vNDV infection and its transmission to sentinels. For this purpose, single vNDV and sequential H9/NDV challenges were performed with increasing doses of vNDV (10(1)-10(6) EID50)...
April 18, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28411501/different-cross-protection-scopes-of-two-avian-influenza-h5n1-vaccines-against-infection-of-layer-chickens-with-a-heterologous-highly-pathogenic-virus
#9
Okti Nadia Poetri, Michiel Van Boven, Guus Koch, Arjan Stegeman, Ivo Claassen, I Wayan Wisaksana, Annemarie Bouma
Avian influenza (AI) virus strains vary in antigenicity, and antigenic differences between circulating field virus and vaccine virus will affect the effectiveness of vaccination of poultry. Antigenic relatedness can be assessed by measuring serological cross-reactivity using haemagglutination inhibition (HI) tests. Our study aims to determine the relation between antigenic relatedness expressed by the Archetti-Horsfall ratio, and reduction of virus transmission of highly pathogenic H5N1 AI strains among vaccinated layers...
April 8, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28408133/a-recombinant-h7n9-influenza-vaccine-with-the-h7-hemagglutinin-transmembrane-domain-replaced-by-the-h3-domain-induces-increased-cross-reactive-antibodies-and-improved-interclade-protection-in-mice
#10
Yang Wang, Jialing Wu, Chunyi Xue, Zhihui Wu, Ying Lin, Ying Wei, Xiaona Wei, Jianru Qin, Yun Zhang, Zhifen Wen, Li Chen, George Dacai Liu, Yongchang Cao
Influenza A H7N9 virus is the latest emerging pandemic threat, and has rapidly diverged into three clades, demanding a H7N9 virus vaccine with broadened protection against unmatched strains. Hemagglutinin (HA)-based structural design approaches for stabilizing HA proteins have provided excitingly promising results. However, none of the HA-based structural design approaches has been applied to a recombinant replicative influenza virus. Here we report that our HA-based structural design approach is a first in the field to generate a recombinant replicative H7N9 virus (H7N9-53TM) showing broadened protection...
April 10, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28401407/molecular-analysis-of-amantadine-resistant-influenza-a-h1n1-pdm09-virus-isolated-from-slum-dwellers-of-dhaka-bangladesh
#11
Mozibur Rahman, Sheikh Ariful Hoque, Mohammad Ariful Islam, Sabita Rezwana Rahman
Influenza is a highly contagious viral infection associated with excessive hospitalizations and deaths throughout the world. Continuous antigenic shift and drift is not only responsible for this devastating effect of influenza but also causes ineffectiveness of antiviral drugs and vaccines. In this study, we investigated the effectiveness of ribavirin, oseltamivir, and amantadine drugs in vitro against nine influenza A isolates collected during June 2012-August 2013 from different slums in Dhaka city. The effectiveness of these drugs was determined by measuring the inhibition of virus-induced cytopathic effect on MDCK cells through MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)...
April 11, 2017: Virus Genes
https://www.readbyqxmd.com/read/28399801/is-the-impact-of-childhood-influenza-vaccination-less-than-expected-a-transmission-modelling-study
#12
Felix Weidemann, Cornelius Remschmidt, Silke Buda, Udo Buchholz, Bernhard Ultsch, Ole Wichmann
BACKGROUND: To reduce the burden of severe influenza, most industrialized countries target specific risk-groups with influenza vaccines, e.g. the elderly or individuals with comorbidities. Since children are the main spreaders, some countries have recently implemented childhood vaccination programs to reduce overall virus transmission and thereby influenza disease in the whole population. The introduction of childhood vaccination programs was often supported by modelling studies that predicted substantial incidence reductions...
April 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28381580/development-of-an-alternative-modified-live-influenza-b-virus-vaccine
#13
Jefferson J S Santos, Courtney Finch, Troy Sutton, Adebimpe Obadan, Isabel Aguirre, Zhimin Wan, Diego Lopez, Ginger Geiger, Ana Silvia Gonzalez-Reiche, Lucas Ferreri, Daniel R Perez
Influenza B virus (IBV) is considered a major human pathogen, responsible for seasonal epidemics of acute respiratory illness. Two antigenically distinct IBV HA lineages co-circulate worldwide with little cross-reactivity between each other. Live attenuated influenza virus vaccines (LAIV) have been shown to provide improved cross-protective immune responses compared to inactivated vaccines by eliciting local mucosal immunity and systemic B cell and T cell-mediated memory responses. We have previously shown that incorporation of temperature sensitive (ts) mutations in the PB1 and PB2 subunits along with a modified HA epitope tag in the C-terminus of PB1 resulted in influenza A viruses (IAV) that are safe and effective as modified live attenuated (att) virus vaccines (IAV att)...
April 5, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28377769/antibody-dependent-cell-mediated-cytotoxicity-epitopes-on-the-hemagglutinin-head-region-of-pandemic-h1n1-influenza-virus-play-detrimental-roles-in-h1n1-infected-mice
#14
Zi-Wei Ye, Shuofeng Yuan, Kwok-Man Poon, Lei Wen, Dong Yang, Zehua Sun, Cun Li, Meng Hu, Huiping Shuai, Jie Zhou, Mei-Yun Zhang, Bo-Jian Zheng, Hin Chu, Kwok-Yung Yuen
Engaging the antibody-dependent cell-mediated cytotoxicity (ADCC) for killing of virus-infected cells and secretion of antiviral cytokines and chemokines was incorporated as one of the important features in the design of universal influenza vaccines. However, investigation of the ADCC epitopes on the highly immunogenic influenza hemagglutinin (HA) head region has been rarely reported. In this study, we determined the ADCC and antiviral activities of two putative ADCC epitopes, designated E1 and E2, on the HA head of a pandemic H1N1 influenza virus in vitro and in a lethal mouse model...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28375554/inflammatory-responses-to-influenza-vaccination-at-the-extremes-of-age
#15
Jacqueline U McDonald, Ziyun Zhong, Helen T Groves, John S Tregoning
Age affects the immune response to vaccination, with individuals at the extremes of age responding poorly. The initial inflammatory response to antigenic materials shapes the subsequent adaptive response and so understanding is required about the effect of age on the profile of acute inflammatory mediators. In this study we measured the local and systemic inflammatory response after influenza vaccination or infection in neonatal, young adult and aged mice. Mice were immunised intramuscularly with inactivated influenza vaccine with and without the adjuvant MF59 and then challenged with H1N1 influenza...
April 4, 2017: Immunology
https://www.readbyqxmd.com/read/28373710/single-cell-imaging-and-quantification-of-tdp-43-and-%C3%AE-synuclein-intercellular-propagation
#16
Sivan Peled, Dorin Sade, Yaron Bram, Ziv Porat, Topaz Kreiser, Michael Mimouni, Alexandra Lichtenstein, Daniel Segal, Ehud Gazit
The intercellular spreading of protein assemblies is a major factor in the progression of neurodegenerative disorders. The quantitative study and visualization of cell-to-cell propagation using tagged-proteins is challenging due to the steric effect of relatively large fluorescence tags and the risk of 'false positive' identification when analyzing these rare transmission events. Here, we established a cell culture model to characterize the cell-to-cell transmission of TAR DNA-binding protein and α-synuclein, involved in amyotrophic lateral sclerosis and Parkinson's disease, respectively, using the small nine amino acid influenza hemagglutinin tag...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28372533/panel-6-vaccines
#17
Melinda M Pettigrew, Mark R Alderson, Lauren O Bakaletz, Stephen J Barenkamp, Anders P Hakansson, Kevin M Mason, Johanna Nokso-Koivisto, Janak Patel, Stephen I Pelton, Timothy F Murphy
Objective To review the literature on progress regarding (1) effectiveness of vaccines for prevention of otitis media (OM) and (2) development of vaccine antigens for OM bacterial and viral pathogens. Data Sources PubMed database of the National Library of Science. Review Methods We performed literature searches in PubMed for OM pathogens and candidate vaccine antigens, and we restricted the searches to articles in English that were published between July 2011 and June 2015. Panel members reviewed literature in their area of expertise...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28364363/preface-emerging-viruses-from-early-detection-to-intervention
#18
Giuseppe Ippolito, Giovanni Rezza
In the last decades, several viruses emerged, as the consequence of cross-species passage from animal reservoirs to human being. Emerging infections always represent a significant challenge for public health system as knowledge about specific pathogens are generally little while and no/few effective interventions are available. In this volume we explored special aspects of emerging infectious diseases including: the application of the theory of focality of diseases to infective syndrome; the human-animal inter-face focusing on influenza; the role of bats as main reservoir of emerging and novel human pathogens; Middle East Respiratory Syndrome Coronavirus (MERS-CoV) epidemiology and clinical presentation; immediate impact on human health of the last Zika virus outbreak occurred in Pacific Ocean and the Americas; the role and potential application of animal models for the study of emerging infections, to improve disease knowledge and for developing therapeutic drugs during ongoing outbreak...
April 1, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28353000/protection-of-chickens-against-h9n2-avian-influenza-virus-challenge-with-recombinant-lactobacillus-plantarum-expressing-conserved-antigens
#19
Wen-Tao Yang, Gui-Lian Yang, Shao-Hua Shi, Yu-Ying Liu, Hai-Bin Huang, Yan-Long Jiang, Jian-Zhong Wang, Chun-Wei Shi, Yu-Bei Jing, Chun-Feng Wang
Avian influenza virus (AIV) is spreading worldwide and is a serious threat to the health of poultry and humans. In many countries, low pathogenic AIVs, such as H9N2, have become an enormous economic burden on the commercial poultry industry because they cause mild respiratory disease and decrease egg production. A recombinant Lactobacillus plantarum NC8 strain expressing NP-M1-DCpep from H9N2 AIV has been studied in a mouse model. However, it remains unknown whether this L. plantarum strain can induce an immune response and provide protection against H9N2 AIV in chickens...
March 29, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28351919/contribution-of-the-purinergic-receptor-p2x7-to-development-of-lung-immunopathology-during-influenza-virus-infection
#20
Victor H Leyva-Grado, Megan E Ermler, Michael Schotsaert, Ma G Gonzalez, Virginia Gillespie, Jean K Lim, Adolfo García-Sastre
An exacerbated immune response is one of the main causes of influenza-induced lung damage during infection. The molecular mechanisms regulating the fate of the initial immune response to infection, either as a protective response or as detrimental immunopathology, are not well understood. The purinergic receptor P2X7 is an ionotropic nucleotide-gated ion channel receptor expressed on immune cells that has been implicated in induction and maintenance of excessive inflammation. Here, we analyze the role of this receptor in a mouse model of influenza virus infection using a receptor knockout (KO) mouse strain...
March 28, 2017: MBio
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