keyword
MENU ▼
Read by QxMD icon Read
search

Influenza challenge studies

keyword
https://www.readbyqxmd.com/read/29666374/hatric-based-identification-of-receptors-for-orphan-ligands
#1
Nadine Sobotzki, Michael A Schafroth, Alina Rudnicka, Anika Koetemann, Florian Marty, Sandra Goetze, Yohei Yamauchi, Erick M Carreira, Bernd Wollscheid
Cellular responses depend on the interactions of extracellular ligands, such as nutrients, growth factors, or drugs, with specific cell-surface receptors. The sensitivity of these interactions to non-physiological conditions, however, makes them challenging to study using in vitro assays. Here we present HATRIC-based ligand receptor capture (HATRIC-LRC), a chemoproteomic technology that successfully identifies target receptors for orphan ligands on living cells ranging from small molecules to intact viruses...
April 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29629040/the-association-between-smoking-status-and-influenza-vaccination-coverage-rate-in-korean-adults-analysis-of-the-2010-2012-korea-national-health-and-nutrition-examination-survey
#2
Jung Keun Park, Soo Lee, Ji Eun Lee, Kyung-Do Han, Ji Hyun Kim, Jin Hee Yoon, Suk Won Park, Yang-Hyun Kim, Kyung-Hwan Cho
Background: Globally, smoking is one of the biggest challenges in public health and is a known cause of several important diseases. Influenza is preventable via annual vaccination, which is the most effective and cost-beneficial method of prevention. However, subjects who smoke have some unhealthy behaviours such as alcohol, low physical activity, and low vaccination rate. In this study, we analyzed the relationship between smoking status and factors potentially related to the influenza vaccination coverage rate in the South Korean adult population...
March 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29627234/nasal-vaccination-with-r4m2e-hsp70c-antigen-encapsulated-into-n-trimethyl-chitosan-tmc-nanoparticulate-systems-preparation-and-immunogenicity-in-a-mouse-model
#3
Mehran Dabaghian, Ali Mohammad Latifi, Majid Tebianian, Hamid NajmiNejad, Seyyed Mahmoud Ebrahimi
In this study, the potential of N-trimethyl chitosan (TMC) nanoparticles as a carrier system for the nasal delivery of the r4M2e.HSP70c, as an M2e-based universal recombinant influenza virus vaccine candidate, was investigated in mice. The anti-M2e specific cellular and humoral immune responses were assessed and the protective efficacy against a 90% lethal dose (LD90) of influenza A/PR/8/34 (H1N1) in a mice model was evaluated. Our results showed that the intranasal immunization of mice with r4M2e.HSP70c+TMC rather than the control groups, r4M2e+TMC, r4M2e and PBS (Phosphate buffer saline), significantly elevated both longevity and serum level of the total M2e-specific IgG antibody with a significant shift in the IgG2a/IgG1 ratio toward IgG2a, induced a Th1 skewed humoral and cellular immune responses, increased IFN-γ, IgG, and IgA in the bronchoalveolar lavage fluid (BALF), and promoted the proliferation of peripheral blood lymphocytes with lower morbidity and mortality rate against viral challenge...
April 4, 2018: Vaccine
https://www.readbyqxmd.com/read/29624615/efficacy-and-synergy-of-live-attenuated-and-inactivated-influenza-vaccines-in-young-chickens
#4
Hyesun Jang, Mohamed Elaish, Mahesh Kc, Michael C Abundo, Amir Ghorbani, John M Ngunjiri, Chang-Won Lee
Outbreaks of novel highly pathogenic avian influenza viruses have been reported in poultry species in the United States since 2014. These outbreaks have proven the limitations of biosecurity control programs, and new tools are needed to reinforce the current avian influenza control arsenal. Some enzootic countries have implemented inactivated influenza vaccine (IIV) in their control programs, but there are serious concerns that a long-term use of IIV without eradication may result in the selection of novel antigenically divergent strains...
2018: PloS One
https://www.readbyqxmd.com/read/29617693/the-protective-effects-of-the-a-zju01-pr8-2013-split-h7n9-avian-influenza-vaccine-against-highly-pathogenic-h7n9-in-balb-c-mice
#5
Xiao-Xin Wu, Xi-Long Deng, Dong-Shan Yu, Wei Yao, Hui-Lin Ou, Tian-Hao Weng, Chen-Yu Hu, Feng-Yu Hu, Nan-Ping Wu, Hangping Yao, Fu-Chun Zhang, Lan-Juan Li
BACKGROUND/AIMS: Since the first case of novel H7N9 infection was reported, China has experienced five epidemics of H7N9. During the fifth wave, a highly pathogenic H7N9 strain emerged. In order to assess whether the H7N9 vaccine based on A/Zhejiang/DTID-ZJU01/2013(H7N9) was effective in protecting against highly pathogenic H7N9, we conducted this study. METHODS: Groups of mice were immunized twice by intraperitoneal injection with 500 µl of either split vaccine alone or MF59-adjuvanted vaccine...
March 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29615248/a-two-dose-immunization-with-an-inactivated-reassortant-h5n2-virus-protects-chickens-against-lethal-challenge-with-homologous-2-3-2-1-clade-and-heterologous-2-2-clade-highly-pathogenic-avian-influenza-h5n1-viruses
#6
Sushant Bhat, Richa Sood, Shweta Shukla, Rekha Khandia, Atul Kumar Pateriya, Naveen Kumar, Vikas Kumar Singh, Semmannan Kalaiyarasu, Manoj Kumar, Sandeep Bhatia
The present study was aimed at generating a reassortant vaccine candidate virus with clade 2.3.2.1 Hemagglutinin (HA) and its evaluation in a challenge study for protection against homologous (2.3.2.1 clade) and heterologous (2.2 clade) highly pathogenic avian influenza (HPAI) H5N1 viruses. Plasmid-based reverse genetics technique was used to rescue a 5 + 3 reassortant H5N2 strain containing the modified HA of H5N1 (clade 2.3.2.1), the Neuraminidase (NA) of H9N2, the Matrix (M) of H5N1 and the internal genes of A/WSN/33 H1N1...
April 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29593719/human-milk-oligosaccharide-2-fucosyllactose-improves-innate-and-adaptive-immunity-in-an-influenza-specific-murine-vaccination-model
#7
Ling Xiao, Thea Leusink-Muis, Nienke Kettelarij, Ingrid van Ark, Bernadet Blijenberg, Nienke A Hesen, Bernd Stahl, Saskia A Overbeek, Johan Garssen, Gert Folkerts, Belinda Van't Land
Background: Human milk is uniquely suited to provide optimal nutrition and immune protection to infants. Human milk oligosaccharides are structural complex and diverse consisting of short chain and long chain oligosaccharides typically present in a 9:1 ratio. 2'-Fucosyllactose (2'FL) is one of the most prominent short chain oligosaccharides and is associated with anti-infective capacity of human milk. Aim: To determine the effect of 2'FL on vaccination responsiveness (both innate and adaptive) in a murine influenza vaccination model and elucidate mechanisms involved...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29592895/kinetic-modeling-of-virus-growth-in-cells
#8
REVIEW
John Yin, Jacob Redovich
When a virus infects a host cell, it hijacks the biosynthetic capacity of the cell to produce virus progeny, a process that may take less than an hour or more than a week. The overall time required for a virus to reproduce depends collectively on the rates of multiple steps in the infection process, including initial binding of the virus particle to the surface of the cell, virus internalization and release of the viral genome within the cell, decoding of the genome to make viral proteins, replication of the genome, assembly of progeny virus particles, and release of these particles into the extracellular environment...
June 2018: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/29571081/intramuscular-and-intranasal-immunization-with-an-h7n9-influenza-virus-like-particle-vaccine-protects-mice-against-lethal-influenza-virus-challenge
#9
Zhiguang Ren, Yongkun Zhao, Jing Liu, Xianliang Ji, Lingnan Meng, Tiecheng Wang, Weiyang Sun, Kun Zhang, Xiaoyu Sang, Zhijun Yu, Yuanguo Li, Na Feng, Hualei Wang, Songtao Yang, Zhengyan Yang, Yuanfang Ma, Yuwei Gao, Xianzhu Xia
The H7N9 influenza virus epidemic has been associated with a high mortality rate in China. Therefore, to prevent the H7N9 virus from causing further damage, developing a safe and effective vaccine is necessary. In this study, a vaccine candidate consisting of virus-like particles (VLPs) based on H7N9 A/Shanghai/2/2013 and containing hemagglutinin (HA), neuraminidase (NA), and matrix protein (M1) was successfully produced using a baculovirus (BV) expression system. Immunization experiments showed that strong humoral and cellular immune responses could be induced by the developed VLPs when administered via either the intramuscular (IM) or intranasal (IN) immunization routes...
March 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29568702/linking-influenza-epidemic-onsets-to-covariates-at-different-scales-using-a-dynamical-model
#10
Marion Roussel, Dominique Pontier, Jean-Marie Cohen, Bruno Lina, David Fouchet
Background: Evaluating the factors favoring the onset of influenza epidemics is a critical public health issue for surveillance, prevention and control. While past outbreaks provide important insights for understanding epidemic onsets, their statistical analysis is challenging since the impact of a factor can be viewed at different scales. Indeed, the same factor can explain why epidemics are more likely to begin (i) during particular weeks of the year (global scale); (ii) earlier in particular regions (spatial scale) or years (annual scale) than others and (iii) earlier in some years than others within a region (spatiotemporal scale)...
2018: PeerJ
https://www.readbyqxmd.com/read/29567461/prep-001-prophylactic-effect-against-rhinovirus-and-influenza-virus-results-of-2-randomized-trials
#11
Bruce Albert Malcolm, Caroline Anne Aerts, Kristof Johan Dubois, Frederik Joris Geurts, Kris Marien, Sarah Rusch, Alex Henri Van Dijck, Rene Verloes, Johan Vingerhoets
BACKGROUND: PrEP-001 Nasal Powder, a proprietary formulation of polyriboinosinic and polyribocytidylic acid effectively elicits a cellular innate immune response in nasal epithelium. The aim of these 2 studies was to investigate the safety and efficacy of PrEP-001 prophylaxis against rhinovirus (HRV-A16) and influenza-A (H3N2-IAV). METHODS: Healthy subjects randomly received 2 doses of PrEP-001 or placebo, 48 and 24 h pre-challenge with 10 TCID50 of HRV-A16 (Study 1) or H3N2-IAV (Study 2)...
March 19, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29563292/activation-and-induction-of-antigen-specific-t-follicular-helper-cells-t-fh-play-a-critical-role-in-laiv-induced-human-mucosal-anti-influenza-antibody-response
#12
Abdullah Aljurayyan, Suttida Puksuriwong, Muhammad Ahmed, Ravi Sharma, Madhan Krishnan, Salil Sood, Katherine Davies, Devika Rajashekar, Sam Leong, Paul S McNamara, Stephen Gordon, Qibo Zhang
There is increasing interest recently in developing intranasal vaccines against respiratory tract infections. Antibody response is critical in vaccine-induced protection and TFH is considered important in mediating antibody response. Most data supporting the role for TFH in antibody response are from animal studies, and direct evidence from humans is limited, apart from TFH -like cells in blood. We studied activation and induction of TFH and its role on anti-influenza antibody response by live-attenuated influenza vaccine(LAIV) in human nasopharynx-associated lymphoid tissue(NALT)...
March 21, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29562878/predicting-risk-of-avian-influenza-a-h5n1-in-egypt-the-creation-of-a-community-level-metric
#13
Ellen C L Geerlings, Claire Heffernan
BACKGROUND: Efficient A(H5N1) control is unlikely to be based on epidemiological data alone. Such control depends on a thorough understanding and appreciation of the interconnectedness of epidemiological, social, and economic factors that contribute to A(H5N1) vulnerability. To date, the control of A(H5N1) in Egypt has been challenging. The disease has been endemic for more than 10 years with a dramatic increase in human cases between December 2014 and March 2015. Part of the problem has been a lack of understanding of the inter-play of drivers, conditions and motives that influence preventive behaviours at the household level...
March 21, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29559173/patients-with-influenza-a-h1n1-pdm09-admitted-to-the-icu-impact-of-the-recommendations-of-the-semicyuc
#14
J Marin-Corral, C Climent, R Muñoz, M Samper, I Dot, C Vilà, J R Masclans, A Rodriguez, I Martin-Loeches, F Álvarez-Lerma
OBJECTIVES: To evaluate the impact of the recommendations of the SEMICYUC (2012) on severe influenza A. DESIGN: A prospective multicenter observational study was carried out. SETTING: ICU. PATIENTS: Patients infected with severe influenza A (H1N1) from the GETGAG/SEMICYUC registry. INTERVENTIONS: Analysis of 2 groups according to the epidemic period of the diagnosis (2009-2011; 2013-2015). VARIABLES: Demographic, temporal, comorbidities, severity, treatments, mortality, late diagnosis and place of acquisition...
March 17, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29555783/secondhand-smoke-induces-inflammation-and-impairs-immunity-to-respiratory-infections
#15
Tariq A Bhat, Suresh Gopi Kalathil, Paul N Bogner, Austin Miller, Paul V Lehmann, Thomas H Thatcher, Richard P Phipps, Patricia J Sime, Yasmin Thanavala
Despite advocacy to reduce smoking-related diseases, >1 billion people worldwide continue to smoke. Smoking is immunosuppressive and an important etiological factor in the development of several human disorders including respiratory diseases like chronic obstructive pulmonary disease. However, there is a critical gap in the knowledge of the role of secondhand smoke (SHS) in inflammation and immunity. We therefore studied the influence of SHS on pulmonary inflammation and immune responses to respiratory infection by nontypeable Haemophilus influenzae (NTHI) recurrently found in chronic obstructive pulmonary disease patients...
March 19, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29545521/sequential-immunizations-with-heterosubtypic-virus-like-particles-elicit-cross-protection-against-divergent-influenza-a-viruses-in-mice
#16
Yuan Luo, Teena Mohan, Wandi Zhu, Chao Wang, Lei Deng, Bao-Zhong Wang
Seasonal influenza vaccines have proven to be effective against well-matched viruses in healthy adults. However, rapid accumulation of mutations in the main antigenic surface proteins of influenza can compromise the efficiency of flu vaccines. Occasionally, influenza pandemics arise and present a different type of challenge to current seasonal vaccines. Novel vaccination strategies that can educate the host immune system to generate immune responses focusing on conserved epitopes on theses antigenic surface proteins are crucial for controlling and limiting influenza epidemics and pandemics...
March 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29540597/antigenically-diverse-swine-origin-h1n1-variant-influenza-viruses-exhibit-differential-ferret-pathogenesis-and-transmission-phenotypes
#17
Joanna A Pulit-Penaloza, Joyce Jones, Xiangjie Sun, Yunho Jang, Sharmi Thor, Jessica A Belser, Natosha Zanders, Hannah M Creager, Callie Ridenour, Li Wang, Thomas J Stark, Rebecca Garten, Li-Mei Chen, John Barnes, Terrence M Tumpey, David E Wentworth, Taronna R Maines, C Todd Davis
Influenza A(H1) viruses circulating in swine represent an emerging virus threat as zoonotic infections occur sporadically following exposure to swine. A fatal infection caused by an H1N1 variant (H1N1v) virus was detected in a patient with reported exposure to swine and who presented with pneumonia, respiratory failure, and cardiac arrest. To understand the genetic and phenotypic characteristics of the virus, genome sequence analysis, antigenic characterization, and ferret pathogenesis and transmissibility experiments were performed...
March 14, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29528337/peptide-mimic-for-influenza-vaccination-using-nonnatural-combinatorial-chemistry
#18
John J Miles, Mai Ping Tan, Garry Dolton, Emily Sj Edwards, Sarah Ae Galloway, Bruno Laugel, Mathew Clement, Julia Makinde, Kristin Ladell, Katherine K Matthews, Thomas S Watkins, Katie Tungatt, Yide Wong, Han Siean Lee, Richard J Clark, Johanne M Pentier, Meriem Attaf, Anya Lissina, Ann Ager, Awen Gallimore, Pierre J Rizkallah, Stephanie Gras, Jamie Rossjohn, Scott R Burrows, David K Cole, David A Price, Andrew K Sewell
Polypeptide vaccines effectively activate human T cells but suffer from poor biological stability, which confines both transport logistics and in vivo therapeutic activity. Synthetic biology has the potential to address these limitations through the generation of highly stable antigenic "mimics" using subunits that do not exist in the natural world. We developed a platform based on D-amino acid combinatorial chemistry and used this platform to reverse engineer a fully artificial CD8+ T cell agonist that mirrored the immunogenicity profile of a native epitope blueprint from influenza virus...
March 12, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29522999/bacillus-licheniformis-in-geogenic-dust-induces-inflammation-in-respiratory-epithelium
#19
Janessa Pickering, Teck Hui Teo, Ruth B Thornton, Lea-Ann Kirkham, Graeme R Zosky, Holly D Clifford
Exposure to environmental geogenic (or earth-derived) dust can lead to more frequent and severe infections in the human airway. Particulate matter < 10 µm (PM10 ) is the component of air pollution that is commonly associated with the exacerbation of respiratory diseases. We have previously demonstrated that mice exposed to geogenic dust PM10 experienced an exacerbation of inflammatory responses to influenza A virus. Whether geogenic dust PM10 also exacerbates respiratory bacterial infection is not yet known, nor are the components of the dust that drive these responses...
March 6, 2018: Environmental Research
https://www.readbyqxmd.com/read/29519593/-i-wouldn-t-really-believe-statistics-challenges-with-influenza-vaccine-acceptance-among-healthcare-workers-in-singapore
#20
Neisha Sundaram, Kathryn Duckett, Chee Fu Yung, Koh Cheng Thoon, Sucitro Sidharta, Indumathi Venkatachalam, Angela Chow, Joanne Yoong
BACKGROUND: Influenza vaccine acceptance among healthcare workers (HCWs) is a worldwide problem, but relatively little research has focussed on Asia, including Singapore. Despite widespread access and recommendations from public health authorities, influenza vaccine uptake remains suboptimal among HCWs. METHODS: Our qualitative study used focus group discussions to identify and explain factors limiting influenza vaccine acceptance among HCWs in Singapore. A total of 73 doctors, nurses, allied health and ancillary staff across three public hospitals were included...
March 5, 2018: Vaccine
keyword
keyword
98020
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"