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late on set bowel inflammatory disease

David J Gibson, Louise Elliott, Edel McDermott, Miriam Tosetto, Denise Keegan, Kathryn Byrne, Sean T Martin, Theo Rispens, Garret Cullen, Hugh E Mulcahy, Adam S Cheifetz, Alan C Moss, Simon C Robson, Glen A Doherty, Elizabeth J Ryan
BACKGROUND: To evaluate whether changes in expression of CD39 by regulatory T lymphocytes (Treg) impact treatment response in inflammatory bowel disease. To then define the biological role of expression of CD39 on Treg in an animal model of colitis. METHODS: A prospective study of consecutive patients commencing anti-tumor necrosis factor therapy with infliximab (IFX) or adalimumab (ADA), who were then followed for 12 months. Treatment responses were defined both symptomatically and by endoscopy showing mucosal healing...
December 2015: Inflammatory Bowel Diseases
Xuexin Yu, Baofeng Lian, Lihong Wang, Yan Zhang, Enyu Dai, Fanlin Meng, Dianming Liu, Shuyuan Wang, Xinyi Liu, Jing Wang, Xia Li, Wei Jiang
Although several studies have investigated the essential roles of inflammation in tumor progression, not many have systematically analyzed gene expression patterns across diverse cancers in the context of inflammation. In this study, in order to better understand the inflammatory scenario, we initially constructed the inflammatory timeline (IT) based on two gene expression profiles during inflammatory progression (inflammatory bowel disease and Helicobacter pylori infection). Then, we separately identified the differentially expressed genes (DEGs) from 25 cancer-related microarray data...
July 29, 2014: Molecular BioSystems
Shana McCormack, Qianghua Xia, Struan F A Grant
In recent years, genome wide association studies have revolutionized the understanding of the genetic architecture of complex disease, particularly in the context of disorders that present in old age, such as type 2 diabetes and cardiovascular disease. This new era is made all the more compelling by the fact that, through extensive validation efforts, there is now very strong consensus among human geneticists on what the key loci are that contribute to the pathogenesis of these traits. However, as these variants have been almost exclusively uncovered in an adult setting, there is the question of when these genetic variants start exerting their effects; indeed many may start setting up an individual's predisposition to a disease of old age very early on in life...
October 2012: Aging and Disease
Byong Duk Ye, Byung Ik Jang, Yoon Tae Jeen, Kang Moon Lee, Joo Sung Kim, Suk-Kyun Yang
Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) with uncertain etiopathogenesis. CD can involve any site of gastrointestinal tract from mouth to anus and is associated with serious complications such as bowel stricture, perforation, abscess, and fistula formation. The incidence and prevalence rates of CD in Korea are still low compared with those of Western countries, but are rapidly increasing during the past decades. The diagnosis of CD is a challenging issue in some clinical situations and it is often difficult to differentiate CD from intestinal tuberculosis or Beh├žet's enterocolitis which are more prevalent in Korea than in Western countries...
March 2009: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
Kouhei Fukushima, Hisao Fujii, Takehira Yamamura, Akira Sugita, Shingo Kameoka, Hirokazu Nagawa, Kitaro Futami, Toshiaki Watanabe, Katsuyoshi Hatakeyama, Toshio Sawada, Kazuhiko Yoshioka, Masato Kusunoki, Fumio Konishi, Masahiko Watanabe, Ken-Ichi Takahashi, Hitoshi Ogawa, Yuji Funayama, Toshifumi Hibi, Iwao Sasaki
"Pouchitis" is a term for nonspecific mucosal inflammation of the pouch after total proctocolectomy and ileal pouch-anal anastomosis for ulcerative colitis. Pouchitis is the most frequent complication of the pelvic pouch at the late stage. To improve the accuracy of the pouchitis diagnosis, sets of clinical symptoms and endoscopic findings (with or without histology of biopsy samples) have previously been evaluated. Endoscopic findings are central to the diagnosis, and a universal consensus of various endoscopic findings must be the initial step toward an objective diagnosis of pouchitis...
October 2007: Journal of Gastroenterology
Jiakang Yu, Salome Gonzalez-Reyes, Juan A Diez-Pardo, Juan A Tovar
BACKGROUND/PURPOSE: Intestinal lesions observed in gastroschisis (Gx) are accompanied by neonatal gastrointestinal dysfunction. This study examines the effects of transplacental dexamethasone on the eviscerated intestine of fetal rats with Gx. METHODS: Gx was created surgically in rat fetuses on gestational day 18, and the dams were treated either with 0.4 mg/kg intraperitoneal dexamethasone or with vehicle only on days 19 and 20. The intestine recovered on day 21 were processed for total DNA and protein...
July 2003: Journal of Pediatric Surgery
Russell L Dedrick, Sarah Bodary, Marvin R Garovoy
Inflammatory disorders such as autoimmune diseases and graft rejection are mediated by activated leukocytes, particularly T lymphocytes, which penetrate the inflamed tissue and perpetuate or amplify the immune reaction. In an unstimulated state, leukocytes do not readily adhere to the vascular endothelium. However, inflammatory signals induce the expression of proteins on the endothelial cell surface that promote the adhesion and extravasation of activated immune cells from the circulation into the underlying tissues...
February 2003: Expert Opinion on Biological Therapy
Jacqueline E Livsey, Jacqueline Routledge, Meriel Burns, Rick Swindell, Susan E Davidson, Richard A Cowan, John P Logue, James P Wylie
BACKGROUND AND PURPOSE: To assess the correlation between different general and organ specific quality of life and morbidity scoring methods in a cohort of men treated with radical radiotherapy for prostate cancer. MATERIALS AND METHODS: Men who had been treated with radical radiotherapy (50 Gy in 16 fractions over 21 days) for localized prostate cancer more than 3 years previously and who had no evidence of recurrent disease were invited to take part in the study...
November 2002: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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