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Virtual molina

Eleftherios Archavlis, Lucas Serrano, Eike Schwandt, Amr Nimer, Moisés Felipe Molina-Fuentes, Tamim Rahim, Maximilian Ackermann, Angelika Gutenberg, Sven Rainer Kantelhardt, Alf Giese
OBJECTIVE The goal of this study was to demonstrate the clinical and technical nuances of a minimally invasive, dorsolateral, tubular approach for partial odontoidectomy, autologous bone augmentation, and temporary C1-2 fixation to treat dens pseudarthrosis. METHODS A cadaveric feasibility study, a 3D virtual reality reconstruction study, and the subsequent application of this approach in 2 clinical cases are reported. Eight procedures were completed in 4 human cadavers. A minimally invasive, dorsolateral, tubular approach for odontoidectomy was performed with the aid of a tubular retraction system, using a posterolateral incision and an oblique approach angle...
September 30, 2016: Journal of Neurosurgery. Spine
Fei Yan, Jiuxia Pang, Yong Peng, Julian R Molina, Ping Yang, Shujun Liu
Although small cell lung cancer (SCLC) is highly responsive to chemotherapies (e.g., cisplatin-etoposide doublet), virtually almost all responsive SCLC patients experience disease recurrence characterized by drug resistance. The mechanisms underlying cisplatin resistance remain elusive. Here we report that cell-intrinsic expression of PD1 and PD-L1, two immune checkpoints, is required for sustained expansion of SCLC cells under cisplatin selection. Indeed, PD1 and PD-L1 were expressed at a higher level in lung cancer cell lines, tumor tissues, and importantly, in SCLC cells resistant to cisplatin (H69R, H82R), when compared to respective controls...
2016: PloS One
Julio Ontiveros-Ravell, Fernando Molina, Maria Almenara-Masbernat, Ignasi Soriano, Eloy Opisso, M Elena Hernando, Josep Maria Tormos, Josep Medina, Enrique J Gómez
This paper introduces a new approach for upper limb neurorehabilitation based on customized devices for monitoring and interacting with virtual environments. A proof-of-concept test involving eight patients at the Guttmann Neurorehabilitation Hospital shows patient's good acceptance and usability scores and demonstrates the technically feasibility of the devices. The final goal is to achieve a more personalized, monitored, intensive and ecological rehabilitation procedures for ABI patients.
2016: Studies in Health Technology and Informatics
Doga Demirel, Alexander Yu, Tansel Halic, Ganesh Sankaranarayanan, Adam Ryason, David Spindler, Kathryn L Butler, Caroline Cao, Emil Petrusa, Marcos Molina, Dan Jones, Suvranu De, Marc Demoya, Stephanie Jones
This paper presents a simulation of Virtual Airway Skill Trainer (VAST) tasks. The simulated tasks are a part of two main airway management techniques; Endotracheal Intubation (ETI) and Cricothyroidotomy (CCT). ETI is a simple nonsurgical airway management technique, while CCT is the extreme surgical alternative to secure the airway of a patient. We developed identification of Mallampati class, finding the optimal angle for positioning pharyngeal/mouth axes tasks for ETI and identification of anatomical landmarks and incision tasks for CCT...
2016: Studies in Health Technology and Informatics
Doga Demirel, Kathryn L Butler, Tansel Halic, Ganesh Sankaranarayanan, David Spindler, Caroline Cao, Emil Petrusa, Marcos Molina, Daniel B Jones, Suvranu De, Marc A deMoya
BACKGROUND: Despite the critical importance of cricothyroidotomy (CCT) for patient in extremis, clinical experience with CCT is infrequent, and current training tools are inadequate. The long-term goal is to develop a virtual airway skills trainer that requires a thorough task analysis to determine the critical procedural steps, learning metrics, and parameters for assessment. METHODS: Hierarchical task analysis is performed to describe major tasks and subtasks for CCT...
September 2016: American Journal of Surgery
Alejandro Lanis, Miguel Padial-Molina, Rami Gamil, Orlando Alvarez del Canto
Computer-guided implant surgery in fresh extraction sites is an underdeveloped procedure. The presence of teeth that will be extracted makes the creation of an appropriate radiographic template for virtual simulation of the rehabilitation impossible. A modified radiographic template is presented to define a digital restorative simulation for the maxillary rehabilitation of a patient with partial edentulism. This modification enables 3-dimensional prosthetic virtual information in regions where teeth will be extracted...
September 2015: Journal of Prosthetic Dentistry
Miguel Rodríguez-Barranco, Fernando Gil, Antonio F Hernández, Juan Alguacil, Andres Lorca, Ramón Mendoza, Inmaculada Gómez, Isabel Molina-Villalba, Beatriz González-Alzaga, Clemente Aguilar-Garduño, Diane S Rohlman, Marina Lacasaña
Over the last few decades there has been an increased concern about the health risks from exposure to metallic trace elements, including arsenic, because of their potential neurotoxic effects on the developing brain. This study assessed whether urinary arsenic (UA) levels are associated with attention performance and Attention-Deficit/Hyperactivity Disorder (ADHD) in children living in an area with high industrial and mining activities in Southwestern Spain. A cross-sectional study was conducted on 261 children aged 6-9 years...
January 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Kimberly F Balsam, Yamile Molina, Jessica A Blayney, Tiara Dillworth, Lindsey Zimmerman, Debra Kaysen
Previous research suggests that sexual minorities are at greater risk for trauma exposure, mental health problems, and substance use. To date, few studies have examined racial/ethnic differences among sexual minorities in relation to health-related behaviors and outcomes. Furthermore, studies of racial/ethnic differences among young adult sexual minority women (SMW) are virtually nonexistent. The current study adds to the previous literature by exploring differences in trauma exposure, sexual identity, mental health, and substance use in a nonprobability national sample of young adult SMW...
July 2015: Cultural Diversity & Ethnic Minority Psychology
Artur Diaz-Carandell, Eugenia Agut-Busquet, Juan Molina-Montes, Oscar Escuder-LaTorre
The reconstruction of mandibular defects has always been of great concern, and it still represents a challenge for head-and-neck reconstructive surgeons. The mandible plays a major role in mastication, articulation, swallowing, respiration, and facial contour. Thus, when undertaking mandibular reconstruction, restoration of both function and cosmetics should be considered as the measure of success. Microsurgical reconstruction is the gold-standard method to repair a segmental mandibular defect. Reconstruction of sizeable defects often needs a large neck incision, leading to unsatisfactory cosmetic outcomes...
August 2014: Plastic and Reconstructive Surgery. Global Open
Karina Iglesia Molina, Natalia Aquaroni Ricci, Suzana Albuquerque de Moraes, Monica Rodrigues Perracini
The use of virtual reality through exergames or active video game, i.e. a new form of interactive gaming, as a complementary tool in rehabilitation has been a frequent focus in research and clinical practice in the last few years. However, evidence of their effectiveness is scarce in the older population. This review aim to provide a summary of the effects of exergames in improving physical functioning in older adults. A search for randomized controlled trials was performed in the databases EMBASE, MEDLINE, PsyInfo, Cochrane data base, PEDro and ISI Web of Knowledge...
2014: Journal of Neuroengineering and Rehabilitation
Jonatan Martínez, Arturo García, Miguel Oliver, José Pascual Molina, Pascual González
The emergence of off-screen interaction devices is bringing the field of virtual reality to a broad range of applications where virtual objects can be manipulated without the use of traditional peripherals. However, to facilitate object interaction, other stimuli such as haptic feedback are necessary to improve the user experience. To enable the identification of virtual 3D objects without visual feedback, a haptic display based on a vibrotactile glove and multiple points of contact gives users an enhanced sensation of touching a virtual object with their hands...
January 2016: IEEE Computer Graphics and Applications
Camilo Cortés, Aitor Ardanza, F Molina-Rueda, A Cuesta-Gómez, Luis Unzueta, Gorka Epelde, Oscar E Ruiz, Alessandro De Mauro, Julian Florez
New motor rehabilitation therapies include virtual reality (VR) and robotic technologies. In limb rehabilitation, limb posture is required to (1) provide a limb realistic representation in VR games and (2) assess the patient improvement. When exoskeleton devices are used in the therapy, the measurements of their joint angles cannot be directly used to represent the posture of the patient limb, since the human and exoskeleton kinematic models differ. In response to this shortcoming, we propose a method to estimate the posture of the human limb attached to the exoskeleton...
2014: BioMed Research International
Alberto Di Somma, Matteo de Notaris, Vita Stagno, Luis Serra, Joaquim Enseñat, Isam Alobid, Joan San Molina, Joan Berenguer, Paolo Cappabianca, Alberto Prats-Galino
INTRODUCTION: The purpose of the present contribution is to perform a detailed anatomic and virtual reality three-dimensional stereoscopic study in order to test the effectiveness of the extended endoscopic endonasal approaches for selected anterior and posterior circulation aneurysms. METHODS: The study was divided in two main steps: (1) simulation step, using a dedicated Virtual Reality System (Dextroscope, Volume Interactions); (2) dissection step, in which the feasibility to reach specific vascular territory via the nose was verified in the anatomical laboratory...
2014: BioMed Research International
Laura Cortés-Sanabria, Carlos A Paredes-Ceseña, Rebeca M Herrera-Llamas, Yolanda Cruz-Bueno, Herman Soto-Molina, Leonardo Pazarín, Margarita Cortés, Héctor R Martínez-Ramírez
BACKGROUND AND AIMS: The use of automated peritoneal dialysis (APD) is increasing compared to continuous ambulatory peritoneal dialysis (CAPD). Surprisingly, little data about health benefits and cost of APD exist, and virtually no information comparing the cost-utility between CAPD and APD is available. We undertook this study to evaluate and compare the health-related quality of life (HRQOL) and cost-utility indexes in patients on CAPD vs. APD METHODS: This was a prospective cohort of patients initiating dialysis (2008-2009)...
November 2013: Archives of Medical Research
Stephen A Schendel, Hagai Hazan-Molina, Adi Rachmiel, Dror Aizenbud
Advancements in computers, prototyping, and imaging, especially over the last 10 years, have permitted the adoption of three-dimensional imaging protocols in the health care field. In this article, the authors present an integrated simulation system for craniofacial surgical planning and treatment. Image fusion technology, which involves combining different imaging modalities, was utilized to create a realistic prototype and virtual image that can be manipulated in real time. The resultant data can then be shared over the Internet with distantly located practitioners...
April 2012: Rambam Maimonides Medical Journal
Nancy Biegler, Paul B McBeth, Corina Tiruta, Douglas R Hamilton, Zhengwen Xiao, Innes Crawford, Martha Tevez-Molina, Nat Miletic, Chad G Ball, Linping Pian, Andrew W Kirkpatrick
BACKGROUND: Point-of-care ultrasound (POC-US) use is increasingly common as equipment costs decrease and availability increases. Despite the utility of POC-US in trained hands, there are many situations wherein patients could benefit from the added safety of POC-US guidance, yet trained users are unavailable. We therefore hypothesized that currently available and economic 'off-the-shelf' technologies could facilitate remote mentoring of a nurse practitioner (NP) to assess for recurrent pneumothoraces (PTXs) after chest tube removal...
2013: Critical Ultrasound Journal
Sergio Castrejón-Castrejón, Armando Pérez-Silva, Elkin González-Villegas, Omar Al-Razzo, Jorge Silvestre, David Doiny, Alejandro Estrada-Mucci, David Filgueiras-Rama, Marta Ortega-Molina, José Luis López-Sendón, José Luis Merino
AIMS: Fluoroscopy is necessary to implant cardioverter defibrillators using the conventional approach. Modern electroanatomic navigation systems allow the visualization of multiple catheters and, as they are capable of rendering precise geometrical reconstructions of cardiac chambers, have been used for fluoroscopy-free electrophysiological procedures. The aim of our study was to assess the feasibility of non-fluoroscopic implants using a three-dimensional navigation system. METHODS AND RESULTS: The NavX system was used to create the virtual anatomies of heart chambers and thoracic veins...
December 2013: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Neil S Calman, Diane Hauser, Linda Weiss, Eve Waltermaurer, Elizabeth Molina-Ortiz, Tongtan Chantarat, Anne Bozack
PURPOSE: The patient-centered medical home (PCMH) model has great potential for optimizing the care of chronically ill patients, yet there is much to be learned about various implementations of this model and their impact on patient care processes and outcomes. METHODS: We examined changes in patterns of health care use in a network of Federally Qualified Health Centers throughout a 9-year period of practice transformation that included recognition of all centers by the National Committee for Quality Assurance (NCQA) as Level 3 PCMH practices...
May 2013: Annals of Family Medicine
Jesús Molina París
The main objectives in the management of chronic disorders such as chronic obstructive pulmonary disease (COPD) are: to suppress or minimize symptoms; to prevent and reduce exacerbations; to avoid limitations in activities of daily living, and thus to enable the patient to lead a normal, or nearly normal, life. COPD has become a serious public-health concern. The disease, which may be life-threatening if not properly managed, often goes undiagnosed. COPD accounts for significant healthcare, social and personal costs, as it can cause disability and lead to marked impairment in patients' quality of life...
April 2013: Expert Review of Respiratory Medicine
Enrique Molina, Eduardo Sobarzo-Sanchez, Alejandro Speck-Planche, Maria Joao Matos, Eugenio Uriarte, Lourdes Santana, Matilde Yanez, Francisco Orallo
With the significant increase of life expectancy of populations in societies today, the importance of the discovery of drugs associated with neurodegenerative diseases has emerged. Therefore, neurodegenerative diseases are an important topic in Medicinal Chemistry. Although drug discovery is considered a complex and slow process, new approaches and methods have been developed with the intention of finding new chemical entities in more efficient ways. This work provides a review of virtual methodologies applied in drug discovery and especially a new model for the prediction of MAO-A inhibitors using a multi-target QSAR methodology...
September 1, 2012: Mini Reviews in Medicinal Chemistry
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