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https://www.readbyqxmd.com/read/28087439/cerebrovascular-heterogeneity-and-neuronal-excitability
#1
REVIEW
Laura Librizzi, Marco de Curtis, Damir Janigro, Leonie Runtz, Frederic deBock, Emmanuel L Barbier, Nicola Marchi
The cerebral vasculature is a complex tridimensional network of arterial and venous vessels which are anatomically in proximity of and functionally coupled to neurons. Depending on the cellular composition of the vascular wall and its anatomical arrangement, cerebral vessels control regional blood flow, define interstitial homeostasis or cerebrospinal fluid circulation and influence immune cell patrolling. Pathological deviations from these functions promote or are a consequence of brain diseases, directly impacting neuronal firing...
January 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28069092/reduced-competence-of-immature-and-mature-oocytes-vitrified-by-cryotop-method-assessment-by-in-vitro-fertilization-and-parthenogenetic-activation-in-a-bovine-model
#2
Daiane L Bulgarelli, Alessandra A Vireque, Caroline P Pitangui-Molina, Marcos F Silva-de-Sá, Ana Carolina J de Sá Rosa-E-Silva
This study aimed to evaluate the embryo development competence, the nuclear maturation and the viability of germinal vesicle (GV) and metaphase II (MII) oocytes vitrified by the Cryotop method. Cumulus-oocyte complexes were derived from bovine ovaries and three experiments were conducted. In Experiment 1, GV oocytes were vitrified and underwent in vitro maturation (IVM) or not and their nuclear maturation was assessed by orcein staining. In Experiment 2, GV oocytes and MII oocytes were vitrified or not and the viability was assessed by calcein/ethidium homodimer-1 staining...
January 10, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28039649/or-fire-virtual-training-simulator-design-and-face-validity
#3
Denis Dorozhkin, Jaisa Olasky, Daniel B Jones, Steven D Schwaitzberg, Stephanie B Jones, Caroline G L Cao, Marcos Molina, Steven Henriques, Jinling Wang, Jeff Flinn, Suvranu De
BACKGROUND: The Virtual Electrosurgical Skill Trainer is a tool for training surgeons the safe operation of electrosurgery tools in both open and minimally invasive surgery. This training includes a dedicated team-training module that focuses on operating room (OR) fire prevention and response. The module was developed to allow trainees, practicing surgeons, anesthesiologist, and nurses to interact with a virtual OR environment, which includes anesthesia apparatus, electrosurgical equipment, a virtual patient, and a fire extinguisher...
December 30, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27983876/risk-factors-of-poor-outcomes-after-admission-for-a-copd-exacerbation-multivariate-logistic-predictive-models
#4
Juan Luis García-Rivero, Cristina Esquinas, Miriam Barrecheguren, Marc Bonnin-Vilaplana, Patricia García-Sidro, Alberto Herrejón, Carlos Martinez-Rivera, Rosa Malo de Molina, Pedro Jorge Marcos, Sagrario Mayoralas, Elsa Naval, Jose Antonio Ros, Manuel Valle, Marc Miravitlles
The aim of this study was to identify a multivariate model to predict poor outcomes after admission for exacerbation of chronic obstructive pulmonary disease (COPD).  We performed a multicenter, observational, prospective study. Patients admitted to hospital for COPD were followed up for 3 months. Relevant clinical variables at admission were selected. For each variable, the best cut-offs for the risk of poor outcome were identified using receiver operating characteristic (ROC) curves. Finally, a stepwise logistic regression model was performed...
December 16, 2016: COPD
https://www.readbyqxmd.com/read/27982231/low-fusing-porcelain-glaze-application-on-3y-tzp-surfaces-can-enhance-zirconia-porcelain-adhesion
#5
Lígia Tiaki Yamamoto, Vinícius Anéas Rodrigues, Lucio Strazzabosco Dornelles, Marco Antonio Bottino, Luiz Felipe Valandro, Renata Marques de Melo
The aim of this study was to assess whether surface treatment improves zirconia-porcelain adhesion. The 3Y-TZP blocks were cut into squares, then polished and sintered. The zirconia surface treatments were performed as follows: no treatment (C); tribochemical silica coating (TBS); glaze application + hydrofluoric acid etching (GA); glaze application + hydrofluoric acid etching + silanization (GAS); deposition of silica nanofilm (NF). After treatments, veneering porcelain cylinders (3.3 x 3.3 mm) were built up on all specimens and fired...
September 2016: Brazilian Dental Journal
https://www.readbyqxmd.com/read/27923328/modeling-stroma-induced-drug-resistance-in-a-tissue-engineered-tumor-model-of-ewing-sarcoma
#6
Marco Santoro, Brian A Menegaz, Salah-Eddine Lamhamedi-Cherradi, Eric R Molina, Danielle Wu, Waldemar Priebe, Joseph A Ludwig, Antonios G Mikos
Three-dimensional (3D) tumor models are gaining traction in the research community given their capacity to mimic aspects of the tumor microenvironment absent in monolayer systems. In particular, the ability to spatiotemporally control cell placement within ex vivo 3D systems has enabled the study of tumor-stroma interactions. Furthermore, by regulating biomechanical stimuli, one can reveal how biophysical cues affect stromal cell phenotype and how their phenotype impacts tumor drug sensitivity. Both tumor architecture and shear force have profound effects on Ewing sarcoma (ES) cell behavior and are known to elicit ligand-mediated activation of the insulin-like growth factor-1 receptor (IGF-1R), thereby mediating resistance of ES cells to IGF-1R inhibitors...
January 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27917839/characterization-and-1-57%C3%A2-%C3%A3-resolution-structure-of-the-key-fire-blight-phosphatase-amsi-from-erwinia-amylovora
#7
Marco Salomone-Stagni, Francesco Musiani, Stefano Benini
AmsI is a low-molecular-weight protein tyrosine phosphatase that regulates the production of amylovoran in the Gram-negative bacterium Erwinia amylovora, a specific pathogen of rosaceous plants such as apple, pear and quince. Amylovoran is an exopolysaccharide that is necessary for successful infection. In order to shed light on AmsI, its structure was solved at 1.57 Å resolution at the same pH as its highest measured activity (pH 5.5). In the active site, a water molecule, bridging between the catalytic Arg15 and the reaction-product analogue sulfate, might be representative of the water molecule attacking the phospho-cysteine intermediate in the second step of the reaction mechanism...
December 1, 2016: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/27908349/truncating-flnc-mutations-are-associated-with-high-risk-dilated-and-arrhythmogenic-cardiomyopathies
#8
Martín F Ortiz-Genga, Sofía Cuenca, Matteo Dal Ferro, Esther Zorio, Ricardo Salgado-Aranda, Vicente Climent, Laura Padrón-Barthe, Iria Duro-Aguado, Juan Jiménez-Jáimez, Víctor M Hidalgo-Olivares, Enrique García-Campo, Chiara Lanzillo, M Paz Suárez-Mier, Hagith Yonath, Sonia Marcos-Alonso, Juan P Ochoa, José L Santomé, Diego García-Giustiniani, Jorge L Rodríguez-Garrido, Fernando Domínguez, Marco Merlo, Julián Palomino, María L Peña, Juan P Trujillo, Alicia Martín-Vila, Davide Stolfo, Pilar Molina, Enrique Lara-Pezzi, Francisco E Calvo-Iglesias, Eyal Nof, Leonardo Calò, Roberto Barriales-Villa, Juan R Gimeno-Blanes, Michael Arad, Pablo García-Pavía, Lorenzo Monserrat
BACKGROUND: Filamin C (encoded by the FLNC gene) is essential for sarcomere attachment to the plasmatic membrane. FLNC mutations have been associated with myofibrillar myopathies, and cardiac involvement has been reported in some carriers. Accordingly, since 2012, the authors have included FLNC in the genetic screening of patients with inherited cardiomyopathies and sudden death. OBJECTIVES: The aim of this study was to demonstrate the association between truncating mutations in FLNC and the development of high-risk dilated and arrhythmogenic cardiomyopathies...
December 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27877112/internal-cholinergic-regulation-of-learning-and-recall-in-a-model-of-olfactory-processing
#9
Licurgo de Almeida, Marco Idiart, Owen Dean, Sasha Devore, David M Smith, Christiane Linster
In the olfactory system, cholinergic modulation has been associated with contrast modulation and changes in receptive fields in the olfactory bulb, as well the learning of odor associations in olfactory cortex. Computational modeling and behavioral studies suggest that cholinergic modulation could improve sensory processing and learning while preventing pro-active interference when task demands are high. However, how sensory inputs and/or learning regulate incoming modulation has not yet been elucidated. We here use a computational model of the olfactory bulb, piriform cortex (PC) and horizontal limb of the diagonal band of Broca (HDB) to explore how olfactory learning could regulate cholinergic inputs to the system in a closed feedback loop...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27876159/natural-radionuclides-in-lichens-mosses-and-ferns-in-a-thermal-power-plant-and-in-an-adjacent-coal-mine-area-in-southern-brazil
#10
Juliana Aparecida Galhardi, Rafael García-Tenorio, Inmaculada Díaz Francés, Daniel Marcos Bonotto, Marcelo Pinto Marcelli
The radio-elements (234)U, (235)U, (238)U, (230)Th, (232)Th and (210)Po were characterized in lichens, mosses and ferns species sampled in an adjacent coal mine area at Figueira City, Paraná State, Brazil, due to their importance for the assessment of human exposure related to the natural radioactivity. The coal is geologically associated with a uranium deposit and has been used as a fossil fuel in a thermal power plant in the city. Samples were initially prepared at LABIDRO (Isotopes and Hydrochemistry Laboratory), UNESP, Rio Claro (SP), Brazil...
February 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/27862834/transcriptional-response-of-erwinia-amylovora-upon-copper-shock-in-vivo-role-of-the-copa-gene
#11
Begoña Águila-Clares, Luisa F Castiblanco, José Manuel Quesada, Ramón Penyalver, Juan Carbonell, María M López, Ester Marco-Noales, George W Sundin
Fire blight is a devastating plant disease caused by the bacterium Erwinia amylovora and its control frequently is based on the use of copper-based compounds, for which the mechanisms of action are not well known. Consequently, here we investigate the response of E. amylovora to copper shock by a whole genome microarray approach. Transcriptional analyses showed that, in the presence of copper, 23 genes were increased in expression; these genes were classified mainly into the transport and stress functional categories...
November 14, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/27835023/correlated-event-by-event-fluctuations-of-flow-harmonics-in-pb-pb-collisions-at-sqrt-s_-nn-2-76%C3%A2-%C3%A2-tev
#12
J Adam, D Adamová, M M Aggarwal, G Aglieri Rinella, M Agnello, N Agrawal, Z Ahammed, S Ahmad, S U Ahn, S Aiola, A Akindinov, S N Alam, D S D Albuquerque, D Aleksandrov, B Alessandro, D Alexandre, R Alfaro Molina, A Alici, A Alkin, J R M Almaraz, J Alme, T Alt, S Altinpinar, I Altsybeev, C Alves Garcia Prado, C Andrei, A Andronic, V Anguelov, T Antičić, F Antinori, P Antonioli, L Aphecetche, H Appelshäuser, S Arcelli, R Arnaldi, O W Arnold, I C Arsene, M Arslandok, B Audurier, A Augustinus, R Averbeck, M D Azmi, A Badalà, Y W Baek, S Bagnasco, R Bailhache, R Bala, S Balasubramanian, A Baldisseri, R C Baral, A M Barbano, R Barbera, F Barile, G G Barnaföldi, L S Barnby, V Barret, P Bartalini, K Barth, J Bartke, E Bartsch, M Basile, N Bastid, S Basu, B Bathen, G Batigne, A Batista Camejo, B Batyunya, P C Batzing, I G Bearden, H Beck, C Bedda, N K Behera, I Belikov, F Bellini, H Bello Martinez, R Bellwied, R Belmont, E Belmont-Moreno, L G E Beltran, V Belyaev, G Bencedi, S Beole, I Berceanu, A Bercuci, Y Berdnikov, D Berenyi, R A Bertens, D Berzano, L Betev, A Bhasin, I R Bhat, A K Bhati, B Bhattacharjee, J Bhom, L Bianchi, N Bianchi, C Bianchin, J Bielčík, J Bielčíková, A Bilandzic, G Biro, R Biswas, S Biswas, S Bjelogrlic, J T Blair, D Blau, C Blume, F Bock, A Bogdanov, H Bøggild, L Boldizsár, M Bombara, J Book, H Borel, A Borissov, M Borri, F Bossú, E Botta, C Bourjau, P Braun-Munzinger, M Bregant, T Breitner, T A Broker, T A Browning, M Broz, E J Brucken, E Bruna, G E Bruno, D Budnikov, H Buesching, S Bufalino, P Buncic, O Busch, Z Buthelezi, J B Butt, J T Buxton, J Cabala, D Caffarri, X Cai, H Caines, L Calero Diaz, A Caliva, E Calvo Villar, P Camerini, F Carena, W Carena, F Carnesecchi, J Castillo Castellanos, A J Castro, E A R Casula, C Ceballos Sanchez, J Cepila, P Cerello, J Cerkala, B Chang, S Chapeland, M Chartier, J L Charvet, S Chattopadhyay, S Chattopadhyay, A Chauvin, V Chelnokov, M Cherney, C Cheshkov, B Cheynis, V Chibante Barroso, D D Chinellato, S Cho, P Chochula, K Choi, M Chojnacki, S Choudhury, P Christakoglou, C H Christensen, P Christiansen, T Chujo, S U Chung, C Cicalo, L Cifarelli, F Cindolo, J Cleymans, F Colamaria, D Colella, A Collu, M Colocci, G Conesa Balbastre, Z Conesa Del Valle, M E Connors, J G Contreras, T M Cormier, Y Corrales Morales, I Cortés Maldonado, P Cortese, M R Cosentino, F Costa, P Crochet, R Cruz Albino, E Cuautle, L Cunqueiro, T Dahms, A Dainese, M C Danisch, A Danu, D Das, I Das, S Das, A Dash, S Dash, S De, A De Caro, G de Cataldo, C de Conti, J de Cuveland, A De Falco, D De Gruttola, N De Marco, S De Pasquale, R D De Souza, A Deisting, A Deloff, E Dénes, C Deplano, P Dhankher, D Di Bari, A Di Mauro, P Di Nezza, B Di Ruzza, M A Diaz Corchero, T Dietel, P Dillenseger, R Divià, Ø Djuvsland, A Dobrin, D Domenicis Gimenez, B Dönigus, O Dordic, T Drozhzhova, A K Dubey, A Dubla, L Ducroux, P Dupieux, R J Ehlers, D Elia, E Endress, H Engel, E Epple, B Erazmus, I Erdemir, F Erhardt, B Espagnon, M Estienne, S Esumi, J Eum, D Evans, S Evdokimov, G Eyyubova, L Fabbietti, D Fabris, J Faivre, A Fantoni, M Fasel, L Feldkamp, A Feliciello, G Feofilov, J Ferencei, A Fernández Téllez, E G Ferreiro, A Ferretti, A Festanti, V J G Feuillard, J Figiel, M A S Figueredo, S Filchagin, D Finogeev, F M Fionda, E M Fiore, M G Fleck, M Floris, S Foertsch, P Foka, S Fokin, E Fragiacomo, A Francescon, A Francisco, U Frankenfeld, G G Fronze, U Fuchs, C Furget, A Furs, M Fusco Girard, J J Gaardhøje, M Gagliardi, A M Gago, K Gajdosova, M Gallio, C D Galvan, D R Gangadharan, P Ganoti, C Gao, C Garabatos, E Garcia-Solis, C Gargiulo, P Gasik, E F Gauger, M Germain, M Gheata, P Ghosh, S K Ghosh, P Gianotti, P Giubellino, P Giubilato, E Gladysz-Dziadus, P Glässel, D M Goméz Coral, A Gomez Ramirez, A S Gonzalez, V Gonzalez, P González-Zamora, S Gorbunov, L Görlich, S Gotovac, V Grabski, O A Grachov, L K Graczykowski, K L Graham, A Grelli, A Grigoras, C Grigoras, V Grigoriev, A Grigoryan, S Grigoryan, B Grinyov, N Grion, J M Gronefeld, J F Grosse-Oetringhaus, R Grosso, L Gruber, F Guber, R Guernane, B Guerzoni, K Gulbrandsen, T Gunji, A Gupta, R Gupta, R Haake, Ø Haaland, C Hadjidakis, M Haiduc, H Hamagaki, G Hamar, J C Hamon, J W Harris, A Harton, D Hatzifotiadou, S Hayashi, S T Heckel, E Hellbär, H Helstrup, A Herghelegiu, G Herrera Corral, B A Hess, K F Hetland, H Hillemanns, B Hippolyte, D Horak, R Hosokawa, P Hristov, C Hughes, T J Humanic, N Hussain, T Hussain, D Hutter, D S Hwang, R Ilkaev, M Inaba, E Incani, M Ippolitov, M Irfan, M Ivanov, V Ivanov, V Izucheev, B Jacak, N Jacazio, P M Jacobs, M B Jadhav, S Jadlovska, J Jadlovsky, C Jahnke, M J Jakubowska, H J Jang, M A Janik, P H S Y Jayarathna, C Jena, S Jena, R T Jimenez Bustamante, P G Jones, A Jusko, P Kalinak, A Kalweit, J Kamin, J H Kang, V Kaplin, S Kar, A Karasu Uysal, O Karavichev, T Karavicheva, L Karayan, E Karpechev, U Kebschull, R Keidel, D L D Keijdener, M Keil, M Mohisin Khan, P Khan, S A Khan, A Khanzadeev, Y Kharlov, B Kileng, D W Kim, D J Kim, D Kim, H Kim, J S Kim, J Kim, M Kim, S Kim, T Kim, S Kirsch, I Kisel, S Kiselev, A Kisiel, G Kiss, J L Klay, C Klein, J Klein, C Klein-Bösing, S Klewin, A Kluge, M L Knichel, A G Knospe, C Kobdaj, M Kofarago, T Kollegger, A Kolojvari, V Kondratiev, N Kondratyeva, E Kondratyuk, A Konevskikh, M Kopcik, M Kour, C Kouzinopoulos, O Kovalenko, V Kovalenko, M Kowalski, G Koyithatta Meethaleveedu, I Králik, A Kravčáková, M Krivda, F Krizek, E Kryshen, M Krzewicki, A M Kubera, V Kučera, C Kuhn, P G Kuijer, A Kumar, J Kumar, L Kumar, S Kumar, P Kurashvili, A Kurepin, A B Kurepin, A Kuryakin, M J Kweon, Y Kwon, S L La Pointe, P La Rocca, P Ladron de Guevara, C Lagana Fernandes, I Lakomov, R Langoy, K Lapidus, C Lara, A Lardeux, A Lattuca, E Laudi, R Lea, L Leardini, G R Lee, S Lee, F Lehas, S Lehner, R C Lemmon, V Lenti, E Leogrande, I León Monzón, H León Vargas, M Leoncino, P Lévai, S Li, X Li, J Lien, R Lietava, S Lindal, V Lindenstruth, C Lippmann, M A Lisa, H M Ljunggren, D F Lodato, P I Loenne, V Loginov, C Loizides, X Lopez, E López Torres, A Lowe, P Luettig, M Lunardon, G Luparello, T H Lutz, A Maevskaya, M Mager, S Mahajan, S M Mahmood, A Maire, R D Majka, M Malaev, I Maldonado Cervantes, L Malinina, D Mal'Kevich, P Malzacher, A Mamonov, V Manko, F Manso, V Manzari, M Marchisone, J Mareš, G V Margagliotti, A Margotti, J Margutti, A Marín, C Markert, M Marquard, N A Martin, J Martin Blanco, P Martinengo, M I Martínez, G Martínez García, M Martinez Pedreira, A Mas, S Masciocchi, M Masera, A Masoni, A Mastroserio, A Matyja, C Mayer, J Mazer, M A Mazzoni, D Mcdonald, F Meddi, Y Melikyan, A Menchaca-Rocha, E Meninno, J Mercado Pérez, M Meres, Y Miake, M M Mieskolainen, K Mikhaylov, L Milano, J Milosevic, A Mischke, A N Mishra, D Miśkowiec, J Mitra, C M Mitu, N Mohammadi, B Mohanty, L Molnar, L Montaño Zetina, E Montes, D A Moreira De Godoy, L A P Moreno, S Moretto, A Morreale, A Morsch, V Muccifora, E Mudnic, D Mühlheim, S Muhuri, M Mukherjee, J D Mulligan, M G Munhoz, K Münning, R H Munzer, H Murakami, S Murray, L Musa, J Musinsky, B Naik, R Nair, B K Nandi, R Nania, E Nappi, M U Naru, H Natal da Luz, C Nattrass, S R Navarro, K Nayak, R Nayak, T K Nayak, S Nazarenko, A Nedosekin, L Nellen, F Ng, M Nicassio, M Niculescu, J Niedziela, B S Nielsen, S Nikolaev, S Nikulin, V Nikulin, F Noferini, P Nomokonov, G Nooren, J C C Noris, J Norman, A Nyanin, J Nystrand, H Oeschler, S Oh, S K Oh, A Ohlson, A Okatan, T Okubo, J Oleniacz, A C Oliveira Da Silva, M H Oliver, J Onderwaater, C Oppedisano, R Orava, M Oravec, A Ortiz Velasquez, A Oskarsson, J Otwinowski, K Oyama, M Ozdemir, Y Pachmayer, D Pagano, P Pagano, G Paić, S K Pal, J Pan, A K Pandey, V Papikyan, G S Pappalardo, P Pareek, W J Park, S Parmar, A Passfeld, V Paticchio, R N Patra, B Paul, H Pei, T Peitzmann, X Peng, H Pereira Da Costa, D Peresunko, E Perez Lezama, V Peskov, Y Pestov, V Petráček, V Petrov, M Petrovici, C Petta, S Piano, M Pikna, P Pillot, L O D L Pimentel, O Pinazza, L Pinsky, D B Piyarathna, M Płoskoń, M Planinic, J Pluta, S Pochybova, P L M Podesta-Lerma, M G Poghosyan, B Polichtchouk, N Poljak, W Poonsawat, A Pop, H Poppenborg, S Porteboeuf-Houssais, J Porter, J Pospisil, S K Prasad, R Preghenella, F Prino, C A Pruneau, I Pshenichnov, M Puccio, G Puddu, P Pujahari, V Punin, J Putschke, H Qvigstad, A Rachevski, S Raha, S Rajput, J Rak, A Rakotozafindrabe, L Ramello, F Rami, R Raniwala, S Raniwala, S S Räsänen, B T Rascanu, D Rathee, K F Read, K Redlich, R J Reed, A Rehman, P Reichelt, F Reidt, X Ren, R Renfordt, A R Reolon, A Reshetin, K Reygers, V Riabov, R A Ricci, T Richert, M Richter, P Riedler, W Riegler, F Riggi, C Ristea, E Rocco, M Rodríguez Cahuantzi, A Rodriguez Manso, K Røed, E Rogochaya, D Rohr, D Röhrich, F Ronchetti, L Ronflette, P Rosnet, A Rossi, F Roukoutakis, A Roy, C Roy, P Roy, A J Rubio Montero, R Rui, R Russo, E Ryabinkin, Y Ryabov, A Rybicki, S Saarinen, S Sadhu, S Sadovsky, K Šafařík, B Sahlmuller, P Sahoo, R Sahoo, S Sahoo, P K Sahu, J Saini, S Sakai, M A Saleh, J Salzwedel, S Sambyal, V Samsonov, L Šándor, A Sandoval, M Sano, D Sarkar, N Sarkar, P Sarma, E Scapparone, F Scarlassara, C Schiaua, R Schicker, C Schmidt, H R Schmidt, M Schmidt, S Schuchmann, J Schukraft, M Schulc, Y Schutz, K Schwarz, K Schweda, G Scioli, E Scomparin, R Scott, M Šefčík, J E Seger, Y Sekiguchi, D Sekihata, I Selyuzhenkov, K Senosi, S Senyukov, E Serradilla, A Sevcenco, A Shabanov, A Shabetai, O Shadura, R Shahoyan, M I Shahzad, A Shangaraev, A Sharma, M Sharma, M Sharma, N Sharma, A I Sheikh, K Shigaki, Q Shou, K Shtejer, Y Sibiriak, S Siddhanta, K M Sielewicz, T Siemiarczuk, D Silvermyr, C Silvestre, G Simatovic, G Simonetti, R Singaraju, R Singh, V Singhal, T Sinha, B Sitar, M Sitta, T B Skaali, M Slupecki, N Smirnov, R J M Snellings, T W Snellman, J Song, M Song, Z Song, F Soramel, S Sorensen, F Sozzi, M Spacek, E Spiriti, I Sputowska, M Spyropoulou-Stassinaki, J Stachel, I Stan, P Stankus, E Stenlund, G Steyn, J H Stiller, D Stocco, P Strmen, A A P Suaide, T Sugitate, C Suire, M Suleymanov, M Suljic, R Sultanov, M Šumbera, S Sumowidagdo, A Szabo, I Szarka, A Szczepankiewicz, M Szymanski, U Tabassam, J Takahashi, G J Tambave, N Tanaka, M Tarhini, M Tariq, M G Tarzila, A Tauro, G Tejeda Muñoz, A Telesca, K Terasaki, C Terrevoli, B Teyssier, J Thäder, D Thakur, D Thomas, R Tieulent, A Tikhonov, A R Timmins, A Toia, S Trogolo, G Trombetta, V Trubnikov, W H Trzaska, T Tsuji, A Tumkin, R Turrisi, T S Tveter, K Ullaland, A Uras, G L Usai, A Utrobicic, M Vala, L Valencia Palomo, S Vallero, J Van Der Maarel, J W Van Hoorne, M van Leeuwen, T Vanat, P Vande Vyvre, D Varga, A Vargas, M Vargyas, R Varma, M Vasileiou, A Vasiliev, A Vauthier, O Vázquez Doce, V Vechernin, A M Veen, M Veldhoen, A Velure, E Vercellin, S Vergara Limón, R Vernet, M Verweij, L Vickovic, J Viinikainen, Z Vilakazi, O Villalobos Baillie, A Villatoro Tello, A Vinogradov, L Vinogradov, Y Vinogradov, T Virgili, V Vislavicius, Y P Viyogi, A Vodopyanov, M A Völkl, K Voloshin, S A Voloshin, G Volpe, B von Haller, I Vorobyev, D Vranic, J Vrláková, B Vulpescu, B Wagner, J Wagner, H Wang, M Wang, D Watanabe, Y Watanabe, M Weber, S G Weber, D F Weiser, J P Wessels, U Westerhoff, A M Whitehead, J Wiechula, J Wikne, G Wilk, J Wilkinson, M C S Williams, B Windelband, M Winn, P Yang, S Yano, Z Yasin, Z Yin, H Yokoyama, I-K Yoo, J H Yoon, V Yurchenko, A Zaborowska, V Zaccolo, A Zaman, C Zampolli, H J C Zanoli, S Zaporozhets, N Zardoshti, A Zarochentsev, P Závada, N Zaviyalov, H Zbroszczyk, I S Zgura, M Zhalov, H Zhang, X Zhang, Y Zhang, C Zhang, Z Zhang, C Zhao, N Zhigareva, D Zhou, Y Zhou, Z Zhou, H Zhu, J Zhu, A Zichichi, A Zimmermann, M B Zimmermann, G Zinovjev, M Zyzak
We report the measurements of correlations between event-by-event fluctuations of amplitudes of anisotropic flow harmonics in nucleus-nucleus collisions, obtained for the first time using a new analysis method based on multiparticle cumulants in mixed harmonics. This novel method is robust against systematic biases originating from nonflow effects and by construction any dependence on symmetry planes is eliminated. We demonstrate that correlations of flow harmonics exhibit a better sensitivity to medium properties than the individual flow harmonics...
October 28, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27827839/the-compositional-hj-biplot-a-new-approach-to-identifying-the-links-among-bioactive-compounds-of-tomatoes
#13
Marcos Hernández Suárez, Daniel Molina Pérez, Elena M Rodríguez-Rodríguez, Carlos Díaz Romero, Francisco Espinosa Borreguero, Purificación Galindo-Villardón
Tomatoes have been described as a functional food because of their particular composition of different bioactive compounds. In this study, the proximate composition, minerals and trace elements, and antioxidant compounds were determined in two tomato cultivars (Mariana and Dunkan) that were grown in Gran Canaria (Spain) either conventionally or hydroponically. Although compositional data of this type require being subjected to the specific statistical techniques of compositional analysis, this approach has not usually been considered in this context...
November 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27826226/analog-memristive-synapse-in-spiking-networks-implementing-unsupervised-learning
#14
Erika Covi, Stefano Brivio, Alexander Serb, Themis Prodromakis, Marco Fanciulli, Sabina Spiga
Emerging brain-inspired architectures call for devices that can emulate the functionality of biological synapses in order to implement new efficient computational schemes able to solve ill-posed problems. Various devices and solutions are still under investigation and, in this respect, a challenge is opened to the researchers in the field. Indeed, the optimal candidate is a device able to reproduce the complete functionality of a synapse, i.e., the typical synaptic process underlying learning in biological systems (activity-dependent synaptic plasticity)...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27822504/sleep-and-serotonin-modulate-paracapsular-nitric-oxide-synthase-expressing-neurons-of-the-amygdala
#15
Marco Bocchio, Simon P Fisher, Gunes Unal, Tommas J Ellender, Vladyslav V Vyazovskiy, Marco Capogna
Unraveling the roles of distinct neuron types is a fundamental challenge to understanding brain function in health and disease. In the amygdala, a brain structure regulating emotional behavior, the diversity of GABAergic neurons has been only partially explored. We report a novel population of GABAergic amygdala neurons expressing high levels of neuronal nitric oxide synthase (nNOS). These cells are predominantly localized along basolateral amygdala (BLA) boundaries. Performing ex vivo patch-clamp recordings from nNOS(+) neurons in Nos1-Cre(ER);Ai9 mice, we observed that nNOS(+) neurons located along the external capsule display distinctive electrophysiological properties, axonal and dendritic arborization, and connectivity...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27815127/larvicidal-activity-of-essential-oil-of-peumus-boldus-molina-and-its-ascaridole-enriched-fraction-against-culex-quinquefasciatus
#16
Débora Silva Borges de Castro, Denise Brentan da Silva, Jacqueline Domingues Tibúrcio, Marcos Eduardo Guerra Sobral, Vany Ferraz, Alex Gutterres Taranto, José Eduardo Serrão, João Máximo de Siqueira, Stênio Nunes Alves
Culex quinquefasciatus (Say, 1823), known as the domestic mosquito, is a common and abundant species throughout the world, and a cosmopolitan species. The adults of this mosquito are important in terms of public and animal health since they display adaptability to different hosts. In humans, they are responsible for the transmission of various diseases. One manner of control of this vector is the use of insecticidal or larvicidal products, which may have the drawback of toxicity to mammals and can be harmful to the environment...
December 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/27799544/neural-correlates-of-specific-musical-anhedonia
#17
Noelia Martínez-Molina, Ernest Mas-Herrero, Antoni Rodríguez-Fornells, Robert J Zatorre, Josep Marco-Pallarés
Although music is ubiquitous in human societies, there are some people for whom music holds no reward value despite normal perceptual ability and preserved reward-related responses in other domains. The study of these individuals with specific musical anhedonia may be crucial to understand better the neural correlates underlying musical reward. Previous neuroimaging studies have shown that musically induced pleasure may arise from the interaction between auditory cortical networks and mesolimbic reward networks...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27799430/study-of-corrosion-in-archaeological-gilded-irons-by-raman-imaging-and-a-coupled-scanning-electron-microscope-raman-system
#18
Marco Veneranda, Ilaria Costantini, Silvia Fdez-Ortiz de Vallejuelo, Laura Garcia, Iñaki García, Kepa Castro, Agustín Azkarate, Juan Manuel Madariaga
In this work, analytical and chemical imaging tools have been applied to the study of a gilded spur found in the medieval necropolis of Erenozar (Bizkaia, Spain). As a first step, a lot of portable equipment has been used to study the object in a non-invasive way. The hand-held energy-dispersive X-ray fluorescence equipment allowed us to characterize the artefact as a rare example of an iron matrix item decorated by means of a fire gilding technique. On the other hand, the use of a portable Raman system helped us to detect the main degradation compounds affecting the spur...
December 13, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/27776181/biological-interactions-and-simulated-climate-change-modulates-the-ecophysiological-performance-of-colobanthus-quitensis-in-the-antarctic-ecosystem
#19
Cristian Torres-Díaz, Jorge Gallardo-Cerda, Paris Lavin, Rómulo Oses, Fernando Carrasco-Urra, Cristian Atala, Ian S Acuña-Rodríguez, Peter Convey, Marco A Molina-Montenegro
Most climate and environmental change models predict significant increases in temperature and precipitation by the end of the 21st Century, for which the current functional output of certain symbioses may also be altered. In this context we address the following questions: 1) How the expected changes in abiotic factors (temperature, and water) differentially affect the ecophysiological performance of the plant Colobanthus quitensis? and 2) Will this environmental change indirectly affect C. quitensis photochemical performance and biomass accumulation by modifying its association with fungal endophytes? Plants of C...
2016: PloS One
https://www.readbyqxmd.com/read/27767173/euchromatin-histone-methyltransferase-1-regulates-cortical-neuronal-network-development
#20
Marijn Bart Martens, Monica Frega, Jessica Classen, Lisa Epping, Elske Bijvank, Marco Benevento, Hans van Bokhoven, Paul Tiesinga, Dirk Schubert, Nael Nadif Kasri
Heterozygous mutations or deletions in the human Euchromatin histone methyltransferase 1 (EHMT1) gene cause Kleefstra syndrome, a neurodevelopmental disorder that is characterized by autistic-like features and severe intellectual disability (ID). Neurodevelopmental disorders including ID and autism may be related to deficits in activity-dependent wiring of brain circuits during development. Although Kleefstra syndrome has been associated with dendritic and synaptic defects in mice and Drosophila, little is known about the role of EHMT1 in the development of cortical neuronal networks...
October 21, 2016: Scientific Reports
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