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https://www.readbyqxmd.com/read/28350943/controversies-in-spinal-trauma-and-evolution-of-care
#1
James S Harrop, George N Rymarczuk, Alexander R Vaccaro, Michael P Steinmetz, Lindsay A Tetreault, Michael G Fehlings
Management of spinal trauma is a complex and rapidly evolving field. To optimize patient treatment algorithms, an understanding of and appreciation for current controversies and advancing technologies in the field of spinal trauma is necessary. Therefore, members of the AOSpine Knowledge Forum Trauma initiative used a modified Delphi method to compile a list of controversial issues and emerging technologies in the field of spinal trauma, and a list of the 14 most relevant topics was generated. A total of 45 440 manuscripts covering the breadth of spine and spinal trauma were initially identified...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28350843/high-hiv-prevalence-and-incidence-among-women-in-southern-mozambique-evidence-from-the-mdp-microbicide-feasibility-study
#2
Sibone Mocumbi, Mitzy Gafos, Khatia Munguambe, Ruth Goodall, Sheena McCormack
BACKGROUND: The study aimed to assess the feasibility of conducting large scale HIV prevention clinical trials in Mozambique by measuring HIV prevalence and incidence among women of reproductive age. This paper describes the baseline socio-demographic characteristics of the Mozambique Microbicides Development Programme (MDP) feasibility cohort, baseline prevalence of HIV and other STIs, and HIV incidence. METHODS: The Mozambique MDP feasibility study was conducted from September 2007 to August 2009 in urban Mavalane and rural Manhiça, in Southern Mozambique...
2017: PloS One
https://www.readbyqxmd.com/read/28346209/accuracy-considerations-in-sterile-compounding
#3
Michael J Akers
Published information about the accuracy of filling and closing operations of sterile products is limited and guidelines on the topic are very general. This article highlights the basic principles in sterile-product filling of syringes and vials. Also covered in this article are descriptions of some of the available devices for filling containers, a brief discussion of the advances in vial and syringe filling, a discussion on the advantages and disadvantages of sterile product filling methods, and a discussion on possible problems encountered during filling operations...
March 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28346048/mabdelivery-administration-routes-for-antibody-therapy-third-labex-mabimprove-industrial-workshop-july-2-2015-tours-france
#4
Elsa Bodier-Montagutelli, Renaud Respaud, Hervé Watier, Audrey Guillon-Munos
The annual "LabEx MAbImprove Industrial Workshops" are primarily intended to provide a comprehensive view about topics of interest for the pharmaceutical industry to scientists involved in research on therapeutic antibodies. The third workshop in this series, held July 2, 2015 in Tours, was dedicated to the optimization of delivery, namely all processes leading monoclonal antibodies to reach their target site. The commonly used intravenous (IV) route, although advantageous in terms of pharmacokinetics and pharmacodynamics, presents some disadvantages in terms of patients' convenience, therapeutic target access or treatment cost...
February 28, 2017: MAbs
https://www.readbyqxmd.com/read/28345401/the-prosody-of-topic-transition-in-interaction-pitch-register-variations
#5
Marine Riou
In conversation, speakers can mobilize a variety of prosodic cues to signal a switch in topics. This paper uses a mixed-methods approach combining Conversation Analysis and Instrumental Prosody to investigate the prosody of topic transition in American English, and analyzes the ways in which speakers can play on register level and on register span. A cluster of three prosodic parameters was found to be predictive of transitions: a higher maximum fundamental frequency (F0), a higher median F0 (key), and an expanded register span...
March 1, 2017: Language and Speech
https://www.readbyqxmd.com/read/28345368/sponsors-and-investigative-staffs-perceptions-of-the-current-investigational-new-drug-safety-reporting-process-in-oncology-trials
#6
Raymond Perez, Patrick Archdeacon, Nancy Roach, Robert Goodwin, Jonathan Jarow, Nina Stuccio, Annemarie Forrest
BACKGROUND/AIMS: The Food and Drug Administration's final rule on investigational new drug application safety reporting, effective from 28 March 2011, clarified the reporting requirements for serious and unexpected suspected adverse reactions occurring in clinical trials. The Clinical Trials Transformation Initiative released recommendations in 2013 to assist implementation of the final rule; however, anecdotal reports and data from a Food and Drug Administration audit indicated that a majority of reports being submitted were still uninformative and did not result in actionable changes...
March 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28345190/new-medicinal-products-for-chronic-heart-failure-advances-in-clinical-trial-design-and-efficacy-assessment
#7
REVIEW
Martin R Cowie, Gerasimos S Filippatos, Maria de Los Angeles Alonso Garcia, Stefan D Anker, Anna Baczynska, Daniel M Bloomfield, Maria Borentain, Karsten Bruins Slot, Maureen Cronin, Pieter A Doevendans, Amany El-Gazayerly, Claudio Gimpelewicz, Narimon Honarpour, Salim Janmohamed, Heidi Janssen, Albert M Kim, Dominik Lautsch, Ian Laws, Martin Lefkowitz, Jose Lopez-Sendon, Alexander R Lyon, Fady I Malik, John J V McMurray, Marco Metra, Santiago Figueroa Perez, Marc A Pfeffer, Stuart J Pocock, Piotr Ponikowski, Krishna Prasad, Isabelle Richard-Lordereau, Lothar Roessig, Giuseppe M C Rosano, Warren Sherman, Wendy Gattis Stough, Karl Swedberg, Benoit Tyl, Faiez Zannad, Caroline Boulton, Pieter De Graeff
Despite the availability of a number of different classes of therapeutic agents with proven efficacy in heart failure, the clinical course of heart failure patients is characterized by a reduction in life expectancy, a progressive decline in health-related quality of life and functional status, as well as a high risk of hospitalization. New approaches are needed to address the unmet medical needs of this patient population. The European Medicines Agency (EMA) is undertaking a revision of its Guideline on Clinical Investigation of Medicinal Products for the Treatment of Chronic Heart Failure...
March 27, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28344122/3-d-evidence-network-plot-system-covariate-imbalances-and-effects-in-network-meta-analysis-explored-using-a-new-software-tool
#8
Sarah Batson, Robert Score, Alex J Sutton
OBJECTIVE: To develop the 3-dimensional (3-D) evidence network plot system - a novel web-based interactive 3-D tool to facilitate the visualisation and exploration of covariate distributions and imbalances across evidence networks for network meta-analysis (NMA). STUDY DESIGN AND SETTING: We developed the 3-D evidence network plot system within an AngularJS environment using a third party JavaScript library (Three.js) to create the 3-D element of the application...
March 23, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28343840/prostate-cancer-screening
#9
REVIEW
Mary Weinstein Dunn
OBJECTIVE: To review the current state of prostate cancer screening and future directions. DATA SOURCES: Nursing, medical and scientific literature related to prostate cancer screening, and national and international professional recommendations. CONCLUSION: Prostate cancer screening has been a topic of robust discussion for a number of years. Research continues to examine novel options for prostate cancer screening to either replace or compliment the prostate specific antigen test, but require additional validation before they will be widely accepted into clinical practice...
March 23, 2017: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/28343764/channelopathies-genetic-testing-and-risk-stratification
#10
Arthur A M Wilde, Ahmad Amin
The cardiac channelopathies are a group of diseases with (disease-) specific electrocardiographic (ECG) characteristics and a disease-specific risk of sudden cardiac death (SCD). This group includes the Long QT Syndromes (LQTS), Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), Brugada Syndrome (BrS), Short QT Syndromes (SQTS), and Early Repolarization Syndrome (ERS). In the past 2 decades the genetic basis for these disease entities has largely been unraveled and that, together with the identification of the genetic basis of the cardiomyopathies, has paved the way for the complete new field of Cardiogenetics...
March 18, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28342946/negait-a-new-parser-for-medical-text-simplification-using-morphological-sentential-and-double-negation
#11
Partha Mukherjee, Gondy Leroy, David Kauchak, Srinidhi Rajanarayanan, Damian Y Romero Diaz, Nicole P Yuan, T Gail Pritchard, Sonia Colina
Many different text features influence text readability and content comprehension. Negation is commonly suggested as one such feature, but few general-purpose tools exist to discover negation and studies of the impact of negation on text readability are rare. In this paper, we introduce a new negation parser (NegAIT) for detecting morphological, sentential, and double negation. We evaluated the parser using a human annotated gold standard containing 500 Wikipedia sentences and achieved 95%, 89% and 67% precision with 100%, 80%, and 67% recall, respectively...
March 22, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28342075/evaluation-of-pre-marketing-factors-to-predict-post-marketing-boxed-warnings-and-safety-withdrawals
#12
Andreas Schick, Kathleen L Miller, Michael Lanthier, Gerald Dal Pan, Clark Nardinelli
INTRODUCTION: An important goal in drug regulation is understanding serious safety issues with new drugs as soon as possible. Achieving this goal requires us to understand whether information provided during the Food and Drug Administration (FDA) drug review can predict serious safety issues that are usually identified after the product is approved. However, research on this topic remains understudied. In this paper, we examine whether any pre-marketing drug characteristics are associated with serious post-marketing safety actions...
March 24, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28341768/public-reactions-to-e-cigarette-regulations-on-twitter-a-text-mining-analysis
#13
Allison J Lazard, Gary B Wilcox, Hannah M Tuttle, Elizabeth M Glowacki, Jessica Pikowski
BACKGROUND: In May 2016, the Food and Drug Administration (FDA) issued a final rule that deemed e-cigarettes to be within their regulatory authority as a tobacco product. News and opinions about the regulation were shared on social media platforms, such as Twitter, which can play an important role in shaping the public's attitudes. We analysed information shared on Twitter for insights into initial public reactions. METHODS: A text mining approach was used to uncover important topics among reactions to the e-cigarette regulations on Twitter...
March 24, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28339055/new-insights-on-old-toxicants-in-occupational-toxicology-review
#14
Chiara Costa, Edoardo Miozzi, Michele Teodoro, Giusi Briguglio, Venerando Rapisarda, Concettina Fenga
In order to deliver the best possible working environment, it is essential to identify professional conditions that could be harmful for worker's health and prevent (or limit) the occurrence of such conditions. The appropriate use of personal protective equipment and the development of appropriate regulations allowed to reduce the prevalence of 'classic' occupational diseases, such as occupational hearing loss or asbestosis, just to name a few. Nowadays, environmental pollution seems to be one of the most relevant concerns for human and animal health, and toxicology is becoming one of the most prominent fields of interest in occupational settings...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28338392/the-effects-of-low-intensity-therapeutic-ultrasound-litus-on-measurable-outcomes-a-critically-appraised-topic
#15
Sarah Daniels, Gabriela Santiago, Jennifer Cuchna, Bonnie Van Lunen
Therapeutic Ultrasound (US) is a popular modality among healthcare professionals and is used to treat a variety of musculoskeletal conditions.(1) Throughout the past 70 years of clinical use,(2) ultrasound has been shown to be an effective way to decrease pain,(2,3) increase tissue temperature,(4) and decrease tissue stiffness of trigger points,(5) amidst other benefits. Treatment parameters with US are typically high-intensity and occur over a short period of time (minutes). The US machine is large and stationary, forcing patients to be non-mobile for the duration of their treatment...
March 24, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28335689/trends-of-occupational-hygiene-in-finland
#16
Rauno Pääkkönen, Milja Koponen
The aim of this work is to evaluate and describe the current status of, and prospects for, the future of occupational hygiene in Finland. The main sources of information include a seminar held in the annual meeting of Finnish Occupational Hygiene Society, and interviews with different stakeholders. Nanotechnology and other new materials, changing work environments, circular economy including green jobs, new medical methods, and advances of construction methods were recognised as future challenges. Future work opportunities for occupational hygiene experts included exposure assessments in indoor air surveys, private consulting and entrepreneurship in general, international activities, and product safety issues...
March 24, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28335451/a-review-of-phage-therapy-against-bacterial-pathogens-of-aquatic-and-terrestrial-organisms
#17
REVIEW
Janis Doss, Kayla Culbertson, Delilah Hahn, Joanna Camacho, Nazir Barekzi
Since the discovery of bacteriophage in the early 1900s, there have been numerous attempts to exploit their innate ability to kill bacteria. The purpose of this report is to review current findings and new developments in phage therapy with an emphasis on bacterial diseases of marine organisms, humans, and plants. The body of evidence includes data from studies investigating bacteriophage in marine and land environments as modern antimicrobial agents against harmful bacteria. The goal of this paper is to present an overview of the topic of phage therapy, the use of phage-derived protein therapy, and the hosts that bacteriophage are currently being used against, with an emphasis on the uses of bacteriophage against marine, human, animal and plant pathogens...
March 18, 2017: Viruses
https://www.readbyqxmd.com/read/28334227/a-phylogenetic-biogeographic-and-taxonomic-study-of-all-extant-species-of-anolis-squamata-iguanidae
#18
Steven Poe, Adrián Nieto-Montes de Oca, Omar Torres-Carvajal, Kevin de Queiroz, Julián A Velasco, Brad Truett, Levi N Gray, Mason J Ryan, Gunther Köhler, Fernando Ayala-Varela, Ian Latella
Anolis lizards (anoles) are textbook study organisms in evolution and ecology. Although several topics in evolutionary biology have been elucidated by the study of anoles, progress in some areas has been hampered by limited phylogenetic information on this group. Here we present a phylogenetic analysis of all 379 extant species of Anolis, with new phylogenetic data for 139 species including new DNA data for 101 species. We use the resulting estimates as a basis for defining anole clade names under the principles of phylogenetic nomenclature and to examine the biogeographic history of anoles...
February 27, 2017: Systematic Biology
https://www.readbyqxmd.com/read/28333952/adjuvant-treatment-with-the-bacterial-lysate-om-85-improves-management-of-atopic-dermatitis-a-randomized-study
#19
Christine Bodemer, Gerard Guillet, Frederic Cambazard, Franck Boralevi, Stefania Ballarini, Christian Milliet, Paola Bertuccio, Carlo La Vecchia, Jean-François Bach, Yves de Prost
BACKGROUND: Environmental factors play a major role on atopic dermatitis (AD) which shows a constant rise in prevalence in western countries over the last decades. The Hygiene Hypothesis suggesting an inverse relationship between incidence of infections and the increase in atopic diseases in these countries, is one of the working hypothesis proposed to explain this trend. OBJECTIVE: This study tested the efficacy and safety of oral administration of the bacterial lysate OM-85 (Broncho-Vaxom®, Broncho-Munal®, Ommunal®, Paxoral®, Vaxoral®), in the treatment of established AD in children...
2017: PloS One
https://www.readbyqxmd.com/read/28332868/is-autoimmunology-a-discipline-of-its-own-a-big-data-based-bibliometric-and-scientometric-analyses
#20
Abdulla Watad, Nicola Luigi Bragazzi, Mohammad Adawi, Howard Amital, Shaye Kivity, Naim Mahroum, Miri Blank, Yehuda Shoenfeld
Autoimmunology is a super-specialty of immunology specifically dealing with autoimmune disorders. To assess the extant literature concerning autoimmune disorders, bibliometric and scientometric analyses (namely, research topics/keywords co-occurrence, journal co-citation, citations, and scientific output trends - both crude and normalized, authors network, leading authors, countries, and organizations analysis) were carried out using open-source software, namely, VOSviewer and SciCurve. A corpus of 169,519 articles containing the keyword "autoimmunity" was utilized, selecting PubMed/MEDLINE as bibliographic thesaurus...
March 23, 2017: Autoimmunity
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