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https://www.readbyqxmd.com/read/28441315/an-overview-of-chronic-spinal-pain-revisiting-diagnostic-categories-and-exploring-an-evolving-role-for-neurostimulation
#1
Ashwini Sharan, Jonathan Riley, Christian Hoelscher
STUDY DESIGN: Topic Overview OBJECTIVE.: To describe the varied etiologies resulting in chronic spinal pain and review the current available evidence for treatments. SUMMARY OF BACKGROUND DATA: Chronic pain conditions, especially those that affect the axial back and radiate to the extremities, affect a large population. This results in pronounced disability and a high socioeconomic burden. Our understanding of the underlying mechanisms for chronic pain is limited...
April 24, 2017: Spine
https://www.readbyqxmd.com/read/28441014/chemistry-inspired-adaptable-framework-structures
#2
Zhiguo Xia, Kenneth R Poeppelmeier
Adaptable crystalline frameworks are important in modern solid-state chemistry as they are able to accommodate a wide range of elements, oxidation states, and stoichiometries. Owing to this ability, such adaptable framework structures are emerging as the prototypes for technologically important advanced functional materials. In this Account, the idea of cosubstitution is explored as a useful "pairing" concept that can potentially lead to the creation of many new members of one particular framework structure...
April 25, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28440992/-autoimmune-inflammatory-syndrome-induced-by-adjuvants-a-new-clinical-entity
#3
Belkis Ferrer-Cosme, Damiana Téllez-Martínez, Alexander Batista-Duharte
Recently Shoenfeld and Agmon-Levin proposed a new clinical entity called autoimmune/inflammatory syndrome induced by adjuvants (ASIA), which includes four clinical entities called: 1) siliconosis, 2) Gulf War syndrome, 3) macrophage myofasciitis) and 4) post-vaccination phenomenon associated with adjuvants. They all have a common denominator: a prior exposure to immunoadjuvants, and, in addition, they also share several clinical criteria associated to chronic inflammation and autoimmune reactions. This proposal still needs to be validated by the scientific community, but nowadays is a topic of hot discussion in the literature and in various international conferences...
May 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28439842/controversies-in-the-multimodality-management-of-locally-advanced-rectal-cancer
#4
REVIEW
Robert Díaz Beveridge, Dilara Akhoundova, Gema Bruixola, Jorge Aparicio
Neoadjuvant radiotherapy previous to radical surgery, both as short-course radiotherapy and as long-course radiotherapy combined with 5-FU-based chemotherapy (LCRCT), is routinely used in the management of locally advanced rectal cancer, with consistent benefits in the reduction in the local relapse risk. Unfortunately, survival benefits have been elusive to demonstrate with this approach, especially in the setting of radical surgery in the form of total mesorectal excision (TME). Concerns about over-treating early-stage patients and about the possible long-term side effects have also cast more doubts in a blanket approach of treating all patients with neoadjuvant radiotherapy, especially with LCRCT...
June 2017: Medical Oncology
https://www.readbyqxmd.com/read/28439266/a-novel-regulator-of-activation-induced-cytidine-deaminase-apobecs-in-immunity-and-cancer-schr%C3%A3-dinger-s-catalytic-pocket
#5
REVIEW
Justin J King, Mani Larijani
Activation-induced cytidine deaminase (AID) and its relative APOBEC3 cytidine deaminases boost immune response by mutating immune or viral genes. Because of their genome-mutating activities, AID/APOBECs are also drivers of tumorigenesis. Due to highly charged surfaces, extensive non-specific protein-protein/nucleic acid interactions, formation of polydisperse oligomers, and general insolubility, structure elucidation of these proteins by X-ray crystallography and NMR has been challenging. Hence, almost all available AID/APOBEC structures are of mutated and/or truncated versions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28439247/when-corporate-social-responsibility-csr-meets-organizational-psychology-new-frontiers-in-micro-csr-research-and-fulfilling-a-quid-pro-quo-through-multilevel-insights
#6
David A Jones, Chelsea R Willness, Ante Glavas
Researchers, corporate leaders, and other stakeholders have shown increasing interest in Corporate Social Responsibility (CSR)-a company's discretionary actions and policies that appear to advance societal well-being beyond its immediate financial interests and legal requirements. Spanning decades of research activity, the scholarly literature on CSR has been dominated by meso- and macro-level perspectives, such as studies within corporate strategy that examine relationships between firm-level indicators of social/environmental performance and corporate financial performance...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28438926/evaluation-of-the-ability-of-a-novel-miconazole-formulation-to-penetrate-nail-using-three-nail-in-vitro-models
#7
Luisa Christensen, Rob Turner, Sean Weaver, Francesco Caserta, Lisa Long, Mahmoud Ghannoum, Marc Brown
In an effort to increase the efficacy of topical medications to treat onychomycosis, several new nail penetration enhancers have recently been developed. In this study, the ability of 10% w/w miconazole nitrate, combined with a penetration enhancer formulation to permeate the nail, is demonstrated by the use of a selection of in vitro nail penetration assays. These assays include bovine hoof, TurChub® zone of inhibition, and infected nail models.
April 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28438235/deception-detection-state-of-the-art-and-future-prospects
#8
Jaume Masip
BACKGROUND: Deception detection has been a longstanding concern throughout human history. It has also interested scientists, who have explored psychological and behavioral differences between liars and truth tellers, as well as ways to improve detection accuracy. METHOD: In recent years, substantial advances have been made in the field. Some of these advances are briefly reviewed in the current article. RESULTS: A description is provided of (a) research and contemporary theories on how people (try to) detect deception; (b) recent advances on strategic interviewing to detect deception; (c) the integrative findings of recent meta-analyses on systematic verbal lie detection approaches; and (d) several important aspects concerning psychophysiological detection of deception...
May 2017: Psicothema
https://www.readbyqxmd.com/read/28436897/tensor-factorized-neural-networks
#9
Jen-Tzung Chien, Yi-Ting Bao
The growing interests in multiway data analysis and deep learning have drawn tensor factorization (TF) and neural network (NN) as the crucial topics. Conventionally, the NN model is estimated from a set of one-way observations. Such a vectorized NN is not generalized for learning the representation from multiway observations. The classification performance using vectorized NN is constrained, because the temporal or spatial information in neighboring ways is disregarded. More parameters are required to learn the complicated data structure...
April 17, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28436504/designing-co2-resistant-oxygen-selective-mixed-ionic-electronic-conducting-membranes-guidelines-recent-advances-and-forward-directions
#10
REVIEW
Chi Zhang, Jaka Sunarso, Shaomin Liu
CO2 resistance is an enabling property for the wide-scale implementation of oxygen-selective mixed ionic-electronic conducting (MIEC) membranes in clean energy technologies, i.e., oxyfuel combustion, clean coal energy delivery, and catalytic membrane reactors for greener chemical synthesis. The significant rise in the number of studies over the past decade and the major progress in CO2-resistant MIEC materials warrant systematic guidelines on this topic. To this end, this review features the pertaining aspects in addition to the recent status and advances of the two most promising membrane materials, perovskite and fluorite-based dual-phase materials...
April 24, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28435946/faraday-discussions-meeting-catalysis-for-fuels
#11
Nico Fischer, Simon A Kondrat, Mzamo Shozi
Welcome to Africa was the motto when after more than 100 years the flag ship conference series of the Royal Society of Chemistry, the Faraday Discussions was hosted for the first time on the African Continent. Under the fitting topic 'Catalysis for Fuels' over 120 delegates followed the invitation by the conference chair Prof. Graham Hutchings FRS (Cardiff Catalysis Institute), his organizing committee and the co-organizing DST-NRF Centre of Excellence in Catalysis c*change (). In the presentations of 21 invited speakers and 59 posters, cutting edge research in the field of catalysis for fuels, designing new catalysts for synthetic fuels, hydrocarbon conversion in the production of synthetic fuels and novel photocatalysis was presented over the two-day meeting...
April 24, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28435269/efficacy-of-silk-fibroin-nano-silver-against-staphylococcus-aureus-biofilms-in-a-rabbit-model-of-sinusitis
#12
Minghui Jia, Zhongchun Chen, Yongwei Guo, Xin Chen, Xia Zhao
BACKGROUND: Staphylococcus aureus biofilms contribute significantly to the recalcitrant nature of chronic rhinosinusitis. In previous studies, it has been shown that silk fibroin-nano silver solution can eliminate S. aureus biofilms in vitro, which suggests a potential role of this novel agent in the treatment of biofilm-associated diseases, such as sinusitis. OBJECTIVE: The aim of this study was to investigate the efficacy of silk fibroin-nano silver solution as a topical anti-biofilm agent in a rabbit model of sinusitis...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28435226/inhibition-of-lymphangiogenesis-in-vitro-and-in-vivo-by-the-multikinase-inhibitor-nintedanib
#13
Tong Lin, Lan Gong
PURPOSE: To investigate the feasibility of nintedanib, a novel triple angiokinase inhibitor, for inhibiting lymphatic endothelial cell (LEC)-induced lymphangiogenesis in vitro and inflammatory corneal lymphangiogenesis in vivo. MATERIALS AND METHODS: Methylthiazolyldiphenyl-tetrazolium bromide (MTT) test, transwell system, and tube-formation assay were used to evaluate the effects of nintedanib on the proliferation, migration, and tube formation of LECs stimulated by vascular endothelial growth factor-C (VEGF-C), basic fibroblast growth factor (bFGF), or platelet-derived growth factor-BB (PDGF-BB)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28435206/new-progress-on-the-operator-inequalities-involving-improved-young-s-and-its-reverse-inequalities-relating-to-the-kantorovich-constant
#14
Jie Zhang, Junliang Wu
The purpose of this paper is to give a survey of the progress, advantages and limitations of various operator inequalities involving improved Young's and its reverse inequalities related to the Kittaneh-Manasrah inequality. We also present our new progress to the related research topics. New scalar versions of Young's inequalities are promoted, the operator version and the Hilbert-Schmidt form also get a promotion.
2017: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/28434919/a-review-of-dtca-techniques-appraising-their-success-and-potential-impact-on-medication-users
#15
REVIEW
Zaheer-Ud-Din Babar, Ashna Medina Siraj, Louise Curley
BACKGROUND: Direct-to-consumer advertising (DTCA) has been present in some countries for nearly two decades. Its success and ramifications have been examined but not yet cataloged recently in a comprehensive manner. OBJECTIVE: To review existing literature studies on the topic of DTCA techniques to provide an analysis of the current methods considered by drug marketers to enhance the effect of pharmaceutical product promotion and its success, as well as examine ramifications on the drug use process...
April 12, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28430733/the-effect-of-tranilast-8-liposomal-gel-versus-placebo-on-postcesarean-surgical-scars-a-prospective-double-blind-split-scar-study
#16
Libi Kohavi, Eli Sprecher, Eyal Zur, Ofir Artzi
BACKGROUND: Tranilast (N-[3, 4-dimethoxycinnamoyl] anthranilic acid), an antiallergic drug, has been shown to attenuate scar formation possibly through inhibition of transforming growth factor beta 1 activity and consequent suppression of collagen synthesis in fibroblasts. OBJECTIVE: The authors aimed at evaluating the efficacy and safety of tranilast 8% gel in improving the appearance and symptoms of new postcesarean section surgical wounds. METHODS: In this prospective double-blind split-scar study, the authors treated each half scar of 26 women with either tranilast 8% liposomal gel or tranilast-free liposomal gel (placebo)...
April 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28430166/-french-phage-network-second-meeting-report
#17
Clara Torres-Barceló, Oliver Kaltz, Rémy Froissart, Sylvain Gandon, Nicolas Ginet, Mireille Ansaldi
The study of bacteriophages (viruses of bacteria) includes a variety of approaches, such as structural biology, genetics, ecology, and evolution, with increasingly important implications for therapeutic and industrial uses. Researchers working with phages in France have recently established a network to facilitate the exchange on complementary approaches, but also to engage new collaborations. Here, we provide a summary of the topics presented during the second meeting of the French Phage Network that took place in Marseille in November 2016...
April 21, 2017: Viruses
https://www.readbyqxmd.com/read/28429916/opportunities-and-barriers-to-public-health-nutrition-education-in-vietnamese-universities
#18
Quynh Th Pham, Anthony Worsley, Mark Lawrence, Bernie Marshall
BACKGROUND AND OBJECTIVES: A core challenge for low- and middle-income countries (LMICs) in combating the negative effects of the nutrition transition is to implement appropriate prevention strategies to halt the increasing prevalence of obesity and non-communicable diseases (NCDs), against a background of prevailing under nutrition. There have been several proposals for the enhancement of university nutrition education for future health and related professionals who are expected to communicate knowledge of health risks to the broad community...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28427666/the-development-of-recent-high-power-ultrasonic-transducers-for-near-well-ultrasonic-processing-technology
#19
Zhenjun Wang, Yuanming Xu
With the reduction of crude oil throughout the world, enhance oil recovery technology has become a major oil research topics, which can greatly increase the recovery ratio of the crude oil before the dawning of renewable energy era. Near-well ultrasonic processing technology, as one new method, has attracted more attention for Enhanced Oil Recovery due to its low cost, good applicability and no environmental pollution in recent rears. There are two important relevant aspects about Near-well ultrasonic processing technology: (a) how to enhance the oil flow through the rocks into the pumping pool and (b) how to reduce the oil viscosity so that it can be easier to pump...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427427/association-between-the-ossific-nucleus-and-osteonecrosis-in-treating-developmental-dysplasia-of-the-hip-updated-meta-analysis
#20
Rafal Niziol, Michael Elvey, Evangelia Protopapa, Andreas Roposch
BACKGROUND: A meta-analysis concluded that there was no effect of the femoral head ossification and the incidence of osteonecrosis in the treatment of developmental dysplasia of the hip (DDH), unless only osteonecrosis grades II-IV were considered. The meta-analysis, limited due to the small number of studies available at that time, identified a need for an update as further research emerges. We observed a trend in recent years towards delaying treatment of DDH in the absence of an ossified nucleus...
April 20, 2017: BMC Musculoskeletal Disorders
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