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https://www.readbyqxmd.com/read/28934746/temperature-probe-placement-during-preterm-infant-resuscitation-a-randomised-trial
#1
Brahim Bensouda, Romain Mandel, Abdelwaheb Mejri, Jean Lachapelle, Marie St-Hilaire, Nabeel Ali
BACKGROUND: Hypothermia on admission to intensive care is associated with poor outcomes in preterm infants. The neonatal resuscitation program recommends the use of servo-control thermoregulation during resuscitation. Very little evidence exists to guide optimal temperature probe placement in the delivery room. OBJECTIVE: The aim of this work was to determine, in moderately preterm infants, if temperature probe placement in the dorsal, thoracic, or axillary area during delivery room resuscitation would result in differing temperatures on admission to the neonatal intensive care unit (NICU)...
September 22, 2017: Neonatology
https://www.readbyqxmd.com/read/28934357/from-bacterial-killing-to-immune-modulation-recent-insights-into-the-functions-of-lysozyme
#2
REVIEW
Stephanie A Ragland, Alison K Criss
Lysozyme is a cornerstone of innate immunity. The canonical mechanism for bacterial killing by lysozyme occurs through the hydrolysis of cell wall peptidoglycan (PG). Conventional type (c-type) lysozymes are also highly cationic and can kill certain bacteria independently of PG hydrolytic activity. Reflecting the ongoing arms race between host and invading microorganisms, both gram-positive and gram-negative bacteria have evolved mechanisms to thwart killing by lysozyme. In addition to its direct antimicrobial role, more recent evidence has shown that lysozyme modulates the host immune response to infection...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28933838/gold-iii-nhc-complexes-for-catalyzing-dihydroalkoxylation-and-hydroamination-reactions
#3
Ashwin G Nair, Roy T McBurney, Mark R D Gatus, Samantha C Binding, Barbara A Messerle
A gold(III) complex of an N-heterocyclic carbene based hemilabile ligand with two pendant pyrazole arms (1,3-bis((1H-pyrazol-3-yl)methyl)-2,3-dihydro-1H-imidazole, LH) was synthesized. Complex [LAu(III)Cl3] is an excellent catalyst for promoting dihydroalkoxylation at room temperature, even catalyzing this reaction at 0 °C. [LAu(III)Cl3] is one of the most efficient catalysts reported to date for the spirocyclization of alkynyl diols. Furthermore, [LAu(III)Cl3] catalyzed intra- and intermolecular hydroamination reactions, achieving good to excellent conversions...
September 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28933578/effects-of-resveratrol-supplementation-on-risk-factors-of-non-communicable-diseases-a-meta-analysis-of-randomized-controlled-trials
#4
Xiao-Fei Guo, Jiao-Mei Li, Jun Tang, Duo Li
The results of randomized controlled trials (RCTs) investigating resveratrol supplementation on risk factors of non-communicable diseases (NCDs) have been inconsistent. The present meta-analysis aimed to quantitatively evaluate the effects of resveratrol intervention on risk factors of NCDs. PubMed and Scopus databases were searched up to June 2017. Weighted mean differences were calculated for net changes in risk factors of NCDs by using a random-effects model. Pre-specified subgroup and univariate meta-regression analyses were carried out to explore the sources of heterogeneity...
September 21, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28933521/the-use-of-covered-stents-in-aortoiliac-obstructions-a-systematic-review-and-meta-analysis-of-the-literature
#5
Joost A Bekken, Hidde Jongsma, Bram Fioole
BACKGROUND: During the past decade, endovascular treatment has become the treatment of choice for all types of aortoiliac occlusive disease, including TASC C and D lesions. Patency rates, however, are still below those of open surgical techniques. One propagated technique to improve patency rates is the use of covered stents. This review assessed the available literature on covered stents for aortoiliac occlusive disease. METHODS: An extensive search was performed of the MEDLINE, Embase, and Cochrane databases...
September 20, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28933198/iatrogenic-injuries-in-percutaneous-pinning-techniques-for-fifth-metacarpal-neck-fractures
#6
Sheriff D Akinleye, Garret Garofolo-Gonzalez, Maya Deza Culbertson, Jack Choueka
BACKGROUND: There is little information regarding anatomic structures at risk during closed percutaneous treatment of fifth metacarpal neck fractures. This study evaluates a variety of common percutaneous techniques with the hypothesis that each approach presents unique risks to tendons and neurovascular structures. METHODS: Seven cadaveric hands were used for this study. The senior author, a board-certified hand surgeon with more than 20 years of experience, used a mini-C arm to pass 1...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28933047/the-right-touch-stroking-of-ct-innervated-skin-promotes-vocal-emotion-processing
#7
Annett Schirmer, Thomas C Gunter
Research has revealed a special mechanoreceptor, called C-tactile (CT) afferent, that is situated in hairy skin and that seems relevant for the processing of social touch. We pursued a possible role of this receptor in the perception of other social signals such as a person's voice. Participants completed three sessions in which they heard surprised and neutral vocal and nonvocal sounds and detected rare sound repetitions. In a given session, participants received no touch or soft brushstrokes to the arm (CT innervated) or palm (CT free)...
September 20, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28932753/effect-of-iop-based-infusion-system-with-and-without-balanced-phaco-tip-on-cumulative-dissipated-energy-and-estimated-fluid-usage-in-comparison-to-gravity-fed-infusion-in-torsional-phacoemulsification
#8
Praveen K Malik, Taru Dewan, Arun Kr Patidar, Ekta Sain
BACKGROUND: To evaluate the effect of three different combinations of tip designs and infusion systems in torsional phacoemulsification (INFINITI and CENTURION) in patients with cataract. According to the manufacturer, two unique improvements in the Centurion are: active fluid dynamic management system and use of an intrepid balanced tip. The study specifically aimed to evaluate the beneficial effects, if any, of change in tip design and infusion system individually and in combination on both per-operative parameters as well as endothelial health over 6 months...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28932108/cognitive-and-behavioral-evaluation-of-nutritional-interventions-in-rodent-models-of-brain-aging-and-dementia
#9
REVIEW
Devin Wahl, Sean Cp Coogan, Samantha M Solon-Biet, Rafael de Cabo, James B Haran, David Raubenheimer, Victoria C Cogger, Mark P Mattson, Stephen J Simpson, David G Le Couteur
Evaluation of behavior and cognition in rodent models underpins mechanistic and interventional studies of brain aging and neurodegenerative diseases, especially dementia. Commonly used tests include Morris water maze, Barnes maze, object recognition, fear conditioning, radial arm water maze, and Y maze. Each of these tests reflects some aspects of human memory including episodic memory, recognition memory, semantic memory, spatial memory, and emotional memory. Although most interventional studies in rodent models of dementia have focused on pharmacological agents, there are an increasing number of studies that have evaluated nutritional interventions including caloric restriction, intermittent fasting, and manipulation of macronutrients...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28931531/clinical-and-cost-effectiveness-of-the-lightning-process-in-addition-to-specialist-medical-care-for-paediatric-chronic-fatigue-syndrome-randomised-controlled-trial
#10
Esther M Crawley, Daisy M Gaunt, Kirsty Garfield, William Hollingworth, Jonathan A C Sterne, Lucy Beasant, Simon M Collin, Nicola Mills, Alan A Montgomery
OBJECTIVE: Investigate the effectiveness and cost-effectiveness of the Lightning Process (LP) in addition to specialist medical care (SMC) compared with SMC alone, for children with chronic fatigue syndrome (CFS)/myalgic encephalitis (ME). DESIGN: Pragmatic randomised controlled open trial. Participants were randomly assigned to SMC or SMC+LP. Randomisation was minimised by age and gender. SETTING: Specialist paediatric CFS/ME service. PATIENTS: 12-18 year olds with mild/moderate CFS/ME...
September 20, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28931202/different-sized-incisions-for-phacoemulsification-in-age-related-cataract
#11
REVIEW
Chongfei Jin, Xinyi Chen, Andrew Law, Yunhee Kang, Xue Wang, Wen Xu, Ke Yao
BACKGROUND: Age-related cataract is the principal cause of blindness and visual impairment in the world. Phacoemulsification is the main surgical procedure used to treat cataract. The comparative effectiveness and safety of different-sized incisions for phacoemulsification has not been determined. OBJECTIVES: The aim of this systematic review was to assess the effectiveness and safety of smaller versus larger incisions for phacoemulsification in age-related cataract...
September 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28931088/an-integrated-nutrition-and-health-program-package-on-iycn-improves-breastfeeding-but-not-complementary-feeding-and-nutritional-status-in-rural-northern-india-a-quasi-experimental-randomized-longitudinal-study
#12
Veena Singh, Saifuddin Ahmed, Michele L Dreyfuss, Usha Kiran, Deepika N Chaudhery, Vinod K Srivastava, Ramesh C Ahuja, Abdullah H Baqui, Gary L Darmstadt, Mathuram Santosham, Keith P West
BACKGROUND: Undernutrition below two years of age remains a major public health problem in India. We conducted an evaluation of an integrated nutrition and health program that aimed to improve nutritional status of young children by improving breast and complementary feeding practices over that offered by the Government of India's standard nutrition and health care program. METHODS: In Uttar Pradesh state, through multi-stage cluster random sampling, 81 villages in an intervention district and 84 villages in a comparison district were selected...
2017: PloS One
https://www.readbyqxmd.com/read/28930490/tezacaftor-ivacaftor-in-subjects-with-cystic-fibrosis-and-f508del-f508del-cftr-or-f508del-g551d-cftr
#13
Scott H Donaldson, Joseph M Pilewski, Matthias Griese, Jon Cooke, Lakshmi Viswanathan, Elizabeth Tullis, Jane C Davies, Julie A Lekstrom-Himes, Linda T Wang
RATIONALE: Tezacaftor (formerly VX-661) is an investigational small molecule that improves processing and trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) in vitro, and improves CFTR function alone and in combination with ivacaftor. OBJECTIVES: To evaluate safety and efficacy of tezacaftor monotherapy and tezacaftor/ivacaftor combination therapy in subjects with CF homozygous for F508del or compound heterozygous for F508del and G551D...
September 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28930080/seroprevalence-of-brucella-antibodies-in-harbor-seals-in-alaska-usa-with-age-regional-and-reproductive-comparisons
#14
A Hoover-Miller, J L Dunn, C L Field, G Blundell, S Atkinson
Populations of harbor seal Phoca vitulina in the Gulf of Alaska have dramatically declined during the past 4 decades. Numbers of seals in Glacier Bay, in southeast Alaska, USA, have also declined despite extensive protection. Causes of the declines and slow recovery are poorly understood. Brucellosis is a zoonotic disease that adversely affects reproduction in many domestic species. We measured the seroprevalence of Brucella antibodies in 554 harbor seals in 3 Alaska locations: Prince William Sound (PWS), Glacier Bay (GB), and Tracy Arm Fords Terror (TAFT) Wilderness Area...
September 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28929919/evaluating-the-efficacy-of-functional-electrical-stimulation-therapy-assisted-walking-after-chronic-motor-incomplete-spinal-cord-injury-effects-on-bone-biomarkers-and-bone-strength
#15
B Catharine Craven, Lora M Giangregorio, S Mohammad Alavinia, Lindsie A Blencowe, Naaz Desai, Sander L Hitzig, Kei Masani, Milos R Popovic
To determine the efficacy of functional electrical stimulation therapy assisted walking (FES-T) compared to a conventional aerobic and resistance training (CONV) with respect to bone biomarkers and lower extremity bone strength outcomes among adults with chronic motor incomplete spinal cord injury (SCI). Design Parallel group randomized controlled trial ( www.clinicaltrials.gov - NCT0020196819). Site Tertiary academic rehabilitation centre in Canada. Methods Adults with chronic (≥18 months) motor incomplete SCI (C2-T12 AIS C-D) were consented and randomized to FES-T or CONV training for 45 minutes thrice-weekly for 4 months...
September 20, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28928706/early-stroke-rehabilitation-of-the-upper-limb-assisted-with-an-electromyography-driven-neuromuscular-electrical-stimulation-robotic-arm
#16
Qiuyang Qian, Xiaoling Hu, Qian Lai, Stephanie C Ng, Yongping Zheng, Waisang Poon
BACKGROUND: Effective poststroke motor rehabilitation depends on repeated limb practice with voluntary efforts. An electromyography (EMG)-driven neuromuscular electrical stimulation (NMES)-robot arm was designed for the multi-joint physical training on the elbow, the wrist, and the fingers. OBJECTIVES: To investigate the training effects of the device-assisted approach on subacute stroke patients and to compare the effects with those achieved by the traditional physical treatments...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28928175/integrated-management-of-atrial-fibrillation-including-tailoring-of-anticoagulation-in-primary-care-study-design-of-the-all-in-cluster-randomised-trial
#17
Carline J van den Dries, Ruud Oudega, Arif Elvan, Frans H Rutten, Sjef J C M van de Leur, Henk J G Bilo, Arno W Hoes, Karel G M Moons, Geert-Jan Geersing
INTRODUCTION: In our ageing society, we are at the merge of an expected epidemic of atrial fibrillation (AF). AF management requires an integrated approach, including rate or rhythm control, stroke prevention with anticoagulation and treatment of comorbidities such as heart failure or type 2 diabetes. As such, primary care seems to be the logical healthcare setting for the chronic management of patients with AF. However, primary care has not yet played a dominant role in AF management, which has been in fact more fragmented between different healthcare providers...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28928023/u-s-army-physical-demands-study-prevalence-and-frequency-of-performing-physically-demanding-tasks-in-deployed-and-non-deployed-settings
#18
Michael W Boye, Bruce S Cohen, Marilyn A Sharp, Maria C Canino, Stephen A Foulis, Kathleen Larcom, Laurel Smith
OBJECTIVES: To compare percentages of on-duty time spent performing physically demanding soldier tasks in non-deployed and deployed settings, and secondarily examine the number of physically demanding tasks performed among five Army combat arms occupational specialties. DESIGN: Job task analysis. METHODS: Soldiers (n=1295; over 99% serving on active duty) across five Army jobs completed one of three questionnaires developed using reviews of job and task related documents, input from subject matter experts, observation of task performance, and conduct of focus groups...
August 31, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28927930/biodegradable-and-adjustable-sol-gel-glass-based-hybrid-scaffolds-from-multi-armed-oligomeric-building-blocks
#19
Christian Kascholke, Stephan Hendrikx, Tobias Flath, Dzmitry Kuzmenka, Hans-Martin Dörfler, Dirk Schumann, Mathias Gressenbuch, F Peter Schulze, Michaela Schulz-Siegmund, Michael C Hacker
Biodegradability is a crucial characteristic to improve the clinical potential of sol-gel-derived glass materials. To this end, a set of degradable organic/inorganic class II hybrids from a tetraethoxysilane(TEOS)-derived silica sol and oligovalent cross-linker oligomers containing oligo(D,L-lactide) domains was developed and characterized. A series of 18 oligomers (Mn: 1100-3200 Da) with different degrees of ethoxylation and varying length of oligoester units was established and chemical composition was determined...
September 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28927680/-digital-action-plan-for-asthma-exacerbations-paname
#20
N Beydon, C Delclaux
BACKGROUND: A written action plan (WAP) reduces emergency visits for asthma exacerbations. However, a WAP is underused and often focused on asthma control. The innovation is an AppWeb that includes an expert software aimed at diagnosing the level of severity of asthma exacerbations and delivering a personalized digital action plan (DAP) when patients are in urgent need of medical advice. Symptoms describing the level of severity of asthma exacerbations and the consequent treatments have been established by working groups of the French Respiratory Societies (SPLF and SP2A for adults and children, respectively)...
September 15, 2017: Revue des Maladies Respiratoires
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