keyword
https://read.qxmd.com/read/38536627/fatal-intoxications-with-zopiclone-a-cause-for-concern
#1
JOURNAL ARTICLE
Lova Tralla, Sara Gustavsson, Carl Söderberg, Anna K Jönsson, Fredrik C Kugelberg
INTRODUCTION: Zopiclone, a controlled substance prescribed for insomnia, has become a common toxicological finding in forensic autopsy cases. This study investigated the role and extent of zopiclone use in fatal intoxications in Sweden. METHODS: All forensic autopsy cases positive for zopiclone in femoral blood during 2012-2020 were selected. Among these cases, fatalities caused by intoxication according to the cause of death certificates issued by the forensic pathologist were identified...
March 27, 2024: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/38535867/phytotherapeutic-approaches-in-canine-pediatrics
#2
REVIEW
Fausto Quintavalla
Phytotherapy is a clinical modality that incorporates botanical remedies as part of the therapeutic approach. It is a very ancient branch of medicine that is currently undergoing a renaissance, evident in the numerous preparations available on the market. The majority of these formulations are for preventive and curative use in adult animals. Experimental experiences in the pediatric age group are particularly scarce within the existing literature. Since these products are readily accessible, dog owners often turn to them due to their ease of availability, a preference for self-medication, and the perception that herbs are safer, gentler, and less expensive than conventional medications, often leading them to bypass seeking the advice of experienced professionals...
March 20, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535033/pulmonary-adverse-events-in-cancer-immunotherapy-case-studies-of-ct-patterns
#3
JOURNAL ARTICLE
Giorgio Bocchini, Maria Chiara Imperato, Tullio Valente, Salvatore Guarino, Roberta Lieto, Candida Massimo, Emanuele Muto, Federica Romano, Mariano Scaglione, Giacomo Sica, Davide Vitagliano Torre, Salvatore Masala, Marialuisa Bocchino, Gaetano Rea
Immune-checkpoint inhibitors have profoundly changed cancer treatment, improving the prognosis of many oncologic patients. However, despite the good efficacy of these drugs, their mechanism of action, which involves the activation of the immune system, can lead to immune-related adverse events, which may affect almost all organs. Pulmonary adverse events are relatively common, and potentially life-threatening complications may occur. The diagnosis is challenging due to the wide and non-specific spectrum of clinical and radiological manifestations...
March 14, 2024: Diagnostics
https://read.qxmd.com/read/38534996/novel-strategy-in-the-detection-of-adverse-cutaneous-drug-reactions-a-case-series-study
#4
JOURNAL ARTICLE
Erika-Gyöngyi Bán, Patrick Lechsner, Eszter-Anna Dho-Nagy, Maria-Antonia Balan, István Major-Szakács, Attila Brassai, Zsuzsánna Simon-Szabó, Corina Ureche
With multimorbidity on the rise, adverse cutaneous drug reactions are becoming a daily challenge in clinical practice. The objective evaluation of the skin lesion is crucial but hardly realized due to missing technology and guidelines. In this study, the novel Dermus SkinScanner-U, an optically guided high-frequency ultrasound imaging device, was evaluated regarding its comparability with the Dermatology Life Quality Index (DLQI) and the pharmacological analysis of the patients' drug therapy. A total of 40 adult patients were evaluated, all with chronic medication use and skin lesions that led to non-compliance toward the pharmacotherapy...
March 7, 2024: Diagnostics
https://read.qxmd.com/read/38534679/the-application-of-knowledge-based-clinical-decision-support-systems-to-detect-antibiotic-allergy
#5
JOURNAL ARTICLE
Nayoung Han, Ock Hee Oh, John Oh, Yoomi Kim, Younghee Lee, Won Chul Cha, Yun Mi Yu
Prevention of drug allergies is important for patient safety. The objective of this study was to evaluate the outcomes of antibiotic allergy-checking clinical decision support system (CDSS), K-CDSTM . A retrospective chart review study was performed in 29 hospitals and antibiotic allergy alerts data were collected from May to August 2022. A total of 15,535 allergy alert cases from 1586 patients were reviewed. The most frequently prescribed antibiotics were cephalosporins (48.5%), and there were more alerts of potential cross-reactivity between beta-lactam antibiotics than between antibiotics with the same ingredients or of the same class...
March 7, 2024: Antibiotics
https://read.qxmd.com/read/38534266/cutaneous-reactions-after-covid-19-vaccines-analysis-of-the-clinical-and-histopathological-spectrum-case-series-and-review-of-the-literature
#6
JOURNAL ARTICLE
Ursina Schmid, Jörg Galambos, Katrin Pfaltz, Ivan Hegyi, Salomé Courvoisier, Werner Kempf
(1) Background: Various cutaneous adverse drug reactions (ADRs) are observed with the implementation of mRNA COVID-19 vaccines. To gain insight into the clinicopathologic features, we analyzed the correlation of histological and clinical data in 48 patients with these ADRs. (2) Methods: Single-center retrospective study in patients with ADRs after mRNA COVID-19 vaccination (mRNA-1273 and BNT162b2 vaccines). (3) Results: Distant generalized ADRs prevailed (91%), often appearing clinically as spongiotic dermatitis or maculopapular exanthema...
March 14, 2024: Dermatopathology (Basel, Switzerland)
https://read.qxmd.com/read/38533933/data-mining-and-safety-analysis-of-traditional-immunosuppressive-drugs-a-pharmacovigilance-investigation-based-on-the-faers-database
#7
JOURNAL ARTICLE
Juan-Juan Li, Li Chen, Yang Zhao, Xue-Qin Yang, Fa-Bin Hu, Li Wang
OBJECTIVE: The purpose of this study aimed to explore the new and serious adverse events(AEs) of Tacrolimus(FK506), cyclosporine(CsA), azathioprine(AZA), mycophenolate mofetil(MMF), cyclophosphamide(CTX) and methotrexate(MTX), which have not been concerned. METHODS: The FAERS data from January 2016 and December 2022 were selected for disproportionality analysis to discover the potential risks of traditional immunosuppressive drugs. RESULTS: Compared with CsA, FK506 has more frequent transplant rejection, and is more related to renal impairment, COVID-19, cytomegalovirus infection and aspergillus infection...
March 27, 2024: Expert Opinion on Drug Safety
https://read.qxmd.com/read/38533858/-not-available
#8
JOURNAL ARTICLE
Iben Rix, Ida Marie Heerfordt, Allan Cramer, Henrik Horwitz, Rasmus Huan Olsen
Modern healthcare requires clinicians to navigate through complex drug treatments. This review offers an overview of sources of drug information which can be used for general medication prescription and for challenging patient populations. Key considerations for pregnant or breastfeeding patients, those with renal impairment, and those with liver dysfunction are discussed. We also touch on adverse drug reactions and drug interactions. Finally, information about services from independent regional drug information centers, that can be used by clinicians, are provided...
March 25, 2024: Ugeskrift for Laeger
https://read.qxmd.com/read/38533255/editorial-research-challenges-of-drug-utilization-data-collection-data-validation-and-adverse-drug-reactions-in-neonates
#9
EDITORIAL
Robert M Ward
No abstract text is available yet for this article.
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38533254/a-real-world-disproportionality-analysis-of-everolimus-data-mining-of-the-public-version-of-fda-adverse-event-reporting-system
#10
JOURNAL ARTICLE
Bin Zhao, Yumei Fu, Shichao Cui, Xiangning Chen, Shu Liu, Lan Luo
Background: Everolimus is an inhibitor of the mammalian target of rapamycin and is used to treat various tumors. The presented study aimed to evaluate the Everolimus-associated adverse events (AEs) through data mining of the US Food and Drug Administration Adverse Event Reporting System (FAERS). Methods: The AE records were selected by searching the FDA Adverse Event Reporting System database from the first quarter of 2009 to the first quarter of 2022. Potential adverse event signals were mined using the disproportionality analysis, including reporting odds ratio the proportional reporting ratio the Bayesian confidence propagation neural network and the empirical Bayes geometric mean and MedDRA was used to systematically classify the results...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38531554/clozapine-induced-pneumonitis-mimicking-an-atypical-pneumonia
#11
JOURNAL ARTICLE
Natasha Marcella Vaselli, Stanley Du Preez, Nuwan Jasenthu Kankanamage
Clozapine is an antipsychotic used for treatment-resistant schizophrenia with a significant side effect profile, including agranulocytosis, myocarditis and fever. Clozapine-induced fever often occurs in the first 2 weeks of treatment and settle after a few days. We report a case of a woman in her mid-30s who developed fever and infective symptoms suggestive of an atypical pneumonia while on clozapine titration. She was on clozapine for 16 days before developing high-grade fever, dry cough, diarrhoea, headache and photophobia with a very high CRP...
March 25, 2024: BMJ Case Reports
https://read.qxmd.com/read/38531249/toxicity-prediction-and-classification-of-gunqile-7-with-small-sample-based-on-transfer-learning-method
#12
JOURNAL ARTICLE
Hongkai Zhao, Sen Qiu, Meirong Bai, Luyao Wang, Zhelong Wang
Drug-induced diseases are the most important component of iatrogenic disease. It is the duty of doctors to provide a reasonable and safe dose of medication. Gunqile-7 is a Mongolian medicine with analgesic and anti-inflammatory effects. As a foreign substance in the body, even with reasonable medication, it may produce varying degrees of adverse reactions or toxic side effects. Since the cost of collecting Gunqile-7 for pharmacological animal trials is high and the data sample is small, this paper employs transfer learning and data augmentation methods to study the toxicity of Gunqile-7...
March 20, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38531022/case-report-macula-structural-and-functional-assessment-in-nab-paclitaxel-related-cystoid-macular-edema
#13
JOURNAL ARTICLE
Lawrence Kwok, Alina Mahmood, Sanjeev Kumar, Andrew Chang
Nab-paclitaxel-related cystoid macular edema is a rare ophthalmic adverse drug reaction. We present a 54-year-old woman with metastatic hormone receptor positive, HER-2 negative breast carcinoma who developed profound bilateral vision loss after the seventh cycle of nab-paclitaxel treatment. Optical coherence tomography and macula microperimetry demonstrated macular edema and decreased threshold sensitivity, respectively. Cessation of nab-paclitaxel improved structural and functional vision after 4 weeks. The introduction of topical dorzolamide 1% in one eye demonstrated further rapid resolution of edema...
March 1, 2024: Ophthalmic Surgery, Lasers & Imaging Retina
https://read.qxmd.com/read/38530547/how-young-radiologists-use-contrast-media-and-manage-adverse-reactions-an-international-survey
#14
JOURNAL ARTICLE
Domenico Albano, Carmen Mallardi, Saif Afat, Paulo Moraes Agnollitto, Damiano Caruso, Roberto Cannella, Serena Carriero, Kalina Chupetlovska, Paola Clauser, Tommaso D'Angelo, Domenico De Santis, Marco Dioguardi Burgio, Ivo Dumic-Cule, Salvatore Claudio Fanni, Stefano Fusco, Marco Gatti, Salvatore Gitto, Sonja Jankovic, Tsvetomir Karagechev, Michail E Klontzas, Emmanouil Koltsakis, Doris Leithner, Vid Matišić, Giuseppe Muscogiuri, Ralitsa Penkova, Michela Polici, Francesca Serpi, Carmelo Sofia, Ziga Snoj, Tugba Akinci D'Antonoli, Federica Vernuccio, João Vieira, Ana Catarina Vieira, Mirjam Wielema, Marta Zerunian, Carmelo Messina
OBJECTIVES: To collect real-world data about the knowledge and self-perception of young radiologists concerning the use of contrast media (CM) and the management of adverse drug reactions (ADR). METHODS: A survey (29 questions) was distributed to residents and board-certified radiologists younger than 40 years to investigate the current international situation in young radiology community regarding CM and ADRs. Descriptive statistics analysis was performed...
March 26, 2024: Insights Into Imaging
https://read.qxmd.com/read/38530518/use-of-nebulized-liposomal-amphotericin-b-and-posaconazole-as-antifungal-prophylaxis-in-patients-with-severe-sars-cov2-infection-in-intensive-care-unit
#15
JOURNAL ARTICLE
Benedetta Fumarola, Liana Signorini, Silvia Lorenzotti, Paola Lanza, Barbara Saccani, Evelyn Van Hauwermeiren, Alice Mulè, Simone Piva, Matteo Rota, Francesco Zuccalà, Francesco Antonio Rasulo, Matteo Filippini, Alberto Bertazzoli, Giovanni Del Fabro, Alberto Matteelli
PURPOSE: COVID-19 associated pulmonary aspergillosis (CAPA) is common and linked with high fatality rates. To assess the impact on the incidence and outcome of CAPA of an antifungal prophylaxis (AFP) we compared two cohorts of COVID-19 patients admitted to intensive care units (ICU) in Brescia, Italy, from January to August 2021. METHODS: The study cohort included all mechanically ventilated patients observed between April 2021 and August 2021 with SARS-CoV-2-pneumonia, who received AFP with oral posaconazole (200 mg every 6 h) and nebulized liposomal amphotericin B (50 mg every 2 weeks) from ICU admission to 7 days after discharge or, if applicable, until tracheostomy removal...
March 26, 2024: Infection
https://read.qxmd.com/read/38530149/drugs-associated-with-a-risk-of-supraventricular-tachycardia-analysis-using-the-openvigil-database
#16
JOURNAL ARTICLE
Weihong Chen, Shaobin Li, Dongqin Huang, Yuchao Su
OBJECTIVE: The OpenVigil database can be used to assess medications that may cause supraventricular tachycardia (SVT) and to produce a reference for their safe use in clinical settings. METHODS: We analyzed first-quarter data from 2004 to 2023, obtained by searching the OpenVigil database using the keyword "supraventricular tachycardia." Trade names and generic names were obtained by querying the RxNav database, and the proportions were summarized. The proportionate reporting ratio (PRR), reporting odds ratio, and chi-square values were also summarized...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38529375/case-report-a-case-of-metastatic-brafv600-mutated-melanoma-with-heart-failure-treated-with-immune-checkpoint-inhibitors-and-braf-mek-inhibitors
#17
Aya Nishizawa, Misaki Kawakami, Yasuyuki Kitahara
BACKGROUND: Novel therapies, immune checkpoint inhibitors (ICIs), and BRAF/MEK inhibitors (BRAFi/MEKi) provide unprecedented survival benefits for patients with advanced melanoma. However, the management of drug-induced adverse events is problematic for both agents and, although rare, can cause serious cardiac dysfunction. CASE REPORT: A 42-year-old male patient with no significant medical history noticed a fading dark brown patch on his left anterior chest, which had been there for 20 years, after his second coronavirus disease 2019 (COVID-19) vaccination...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38528553/extracorporeal-photopheresis-reduces-inflammation-and-joint-damage-in-a-rheumatoid-arthritis-murine-model
#18
JOURNAL ARTICLE
Yuwei Lin, Zhanrui Cheng, Yan Zhong, Yinting Zhao, Guifen Xiang, Ling Li, Li Tian, Zhong Liu
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammatory reactions and tissue damage in the joints. Long-term drug use in clinical practice is often accompanied by adverse reactions. Extracorporeal photopheresis (ECP) is an immunomodulatory therapy with few side effects, offering a potential and safe therapeutic alternative for RA through the induction of immune tolerance. This study aimed to investigate the therapeutic effects of ECP on RA using a collagen-induced arthritis (CIA) murine model, as well as to explore its immunomodulatory effects in vivo...
March 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38528338/pharmacogenomics-in-clinical-practice-for-older-people
#19
JOURNAL ARTICLE
Syeda R Hashimi, Olajumoke Babatunde, Khalifa Alrajeh, Richard J Dixon, Aimalohi Okpeku, Elvin T Price
Older people are over-represented among individuals that experience adverse drug reactions (ADR) and adverse drug events (ADE). Furthermore, older people are over-represented among individuals that visit emergency departments and are hospitalized because of ADRs. Moreover, older people are overrepresented among those who suffer ADEs while hospitalized. Finally, older people are among those most likely to have an anaphylactic response to prescription medications. Therefore, older people are prime candidates for efforts aimed at optimizing pharmacotherapeutic outcomes...
April 1, 2024: Senior Care Pharmacist
https://read.qxmd.com/read/38527971/design-and-validation-of-algorithms-to-identify-venous-thromboembolism-in-the-french-national-healthcare-database
#20
JOURNAL ARTICLE
Nicolas H Thurin, Angela Grelaud, Adeline Grolleau, Marie-Agnès Bernard, Emmanuelle Bignon, Patrick Blin, Régis Lassalle, Cécile Droz-Perroteau
PURPOSE: This paper aims to introduce an algorithm designed to identify Venous Thromboembolism (VTE) in the French National Healthcare Database (SNDS) and to estimate its positive predictive value. METHODS: A case-identifying algorithm was designed using SNDS inpatient and outpatient encounters, including hospital stays with discharge diagnoses, imaging procedures and drugs dispensed, of French patients aged at least 18 years old to whom baricitinib or Tumor Necrosis Factor Inhibitors (TNFi) were dispensed between September 1, 2017, and December 31, 2018...
April 2024: Pharmacoepidemiology and Drug Safety
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