Federica Klaus, Hui Xin Ng, Izabela G Barbosa, Alexandra Beunders, Farren Briggs, Katherine E Burdick, Annemieke Dols, Orestes Forlenza, Ariel Gildengers, Caitlin Millett, Benoit H Mulsant, Melis Orhan, Tarek K Rajji, Soham Rej, Martha Sajatovic, Kaylee Sarna, Sigfried Schouws, Ashley Sutherland, Antonio L Teixeira, Joy A Yala, Lisa T Eyler
BACKGROUND: Cognitive deficits in bipolar disorder (BD) impact functioning and are main contributors to disability in older age BD (OABD). We investigated the difference between OABD and age-comparable healthy comparison (HC) participants and, among those with BD, the associations between age, global cognitive performance, symptom severity and functioning using a large, cross-sectional, archival dataset harmonized from 7 international OABD studies. METHODS: Data from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) database, spanning various standardized measures of cognition, functioning and clinical characteristics, were analyzed...
March 26, 2024: Journal of Affective Disorders