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https://www.readbyqxmd.com/read/29160338/changes-in-energy-and-motor-activity-core-symptoms-of-bipolar-mania-and-depression
#1
Elie Cheniaux, Rafael de A da Silva, Cristina M Santana, Alberto Filgueiras
OBJECTIVE: To evaluate how well symptom rating scales differentiate bipolar disorder (BD) episode types. METHODS: One hundred and six patients with BD were followed for 13 years. At each visit, the following clinical scales were administered: Young Mania Rating Scale (YMRS), Hamilton Depression Scale (HAM-D) and Clinical Global Impressions scale for use in bipolar illness (CGI-BP). To perform a comparison between the affective states of BP, three time points in each patient's follow-up period were chosen for evaluation: the most severe manic episode, the most severe depressive episode, and the euthymic period with least symptoms...
November 9, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29152847/a-case-study-in-identifying-targeted-patients-population-in-major-depressive-disorder-by-enhanced-enrichment-design
#2
Peter Zhang, Kevin Carroll, Mary Hobart, Carole Augustine, Gary Koch
Despite advances in clinical trial design, failure rates near 80% in phase 2 and 50% in phase 3 have recently been reported. The challenges to successful drug development are particularly acute in central nervous system trials such as for pain, schizophrenia, mania, and depression because high-placebo response rates lessen assay sensitivity, diminish estimated treatment effect sizes, and thereby decrease statistical power. This paper addresses the importance of rigorous patient selection in major depressive disorder trials through an enhanced enrichment paradigm...
November 19, 2017: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/29146409/safety-and-effectiveness-of-long-term-treatment-with-lurasidone-in-older-adults-with-bipolar-depression-post-hoc-analysis-of-a-6-month-open-label-study
#3
Brent P Forester, Martha Sajatovic, Joyce Tsai, Andrei Pikalov, Josephine Cucchiaro, Antony Loebel
OBJECTIVE: To evaluate the safety and effectiveness of 6 months of treatment with lurasidone in older adults with a diagnosis of bipolar I depression. DESIGN: Post-hoc analysis of a multicenter, 6-month, open-label extension study. SETTING: Outpatient. PARTICIPANTS: Patients aged 55 to 75 years with a DSM-IV-TR diagnosis of bipolar I depression who had completed 6 weeks of double-blind, placebo-controlled treatment with either lurasidone monotherapy (1 study) or adjunctive therapy with lithium or valproate (2 studies)...
October 10, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29145183/catastrophe-reaction-and-emotionalism
#4
Antonio Carota, Julien Bogousslavsky
The catastrophic reaction (CR; a disruptive and uncontrolled behavior triggered by anger, irritability, and hostility) and emotionalism (a condition of uncontrolled crying or laughing) are disorders of the emotional regulation and expression, the prevalence of which is underestimated in neurology. Their occurrence is an additional factor of poor outcome for neurologic patients. Although they have been recognized and completely described in their clinical manifestations more than a century ago, many issues remain unsolved regarding their pathogenesis and the respective role of the brain damage and psychological factors...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29128113/measurement-equivalence-of-the-bdsx-scale-with-young-and-older-adults-with-bipolar-disorder
#5
Norm O'Rourke, Yaacov G Bachner, Sarah L Canham, Andrew Sixsmith, Badas Study Team
Instruments developed for mental health research are commonly devised and validated with young adults only. However, the measurement properties of these scales may differ over the lifespan. For this study, we set out to demonstrate the psychometric equivalence of the BDSx scale with an international sample of young and older adults with bipolar disorder (BD). We independently replicated the 4-factor model of BDSx responses with young and older participants (M = 45.63, range 19-87 years of age); we then compared the psychometric properties between models...
October 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29121879/hypnotic-susceptibility-and-affective-states-in-bipolar-i-and-ii-disorders
#6
Bingren Zhang, Jiawei Wang, Qisha Zhu, Guorong Ma, Chanchan Shen, Hongying Fan, Wei Wang
BACKGROUND: Highly hypnotizable individuals have impaired executive function, elevated motor impulsivity and increased emotional sensitivity, which are sometimes found in bipolar disorder patients. It is then reasonable to assume that certain aspects of hypnotic susceptibility differ with the types of bipolar disorder. METHODS: The Stanford Hypnotic Susceptibility Scale: Form C (SHSS:C) test, the Mood Disorder Questionnaire (MDQ), the Hypomanic Checklist-32 (HCL-32) and the Plutchick-van Praag Depression Inventory (PVP) were applied to 62 patients with bipolar I disorder, 33 bipolar II disorder, and 120 healthy volunteers...
November 9, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29120844/prevalence-and-clinical-demographic-correlates-of-hyperhomocysteinemia-in-inpatients-with-bipolar-disorder-in-a-han-chinese-population
#7
Shuang-Jiang Zhou, Li-Gang Zhang, Hong-Mei Chen, Ju-Yan Li, Ran Li, Xi-Mei Zhang, Ning Wang, Jair C Soares, Ryan M Cassidy, Yingjun Zheng, Yuping Ning, Shao-Li Wang, Jing-Xu Chen, Xiang-Yang Zhang
Recent studies have reported that hyperhomocystinemia (HHcy) is highly prevalent in patients with bipolar disorder (BD), placing them at greater risk of cardiovascular disease and possibly serving as a disease biomarker. However, the correlation of HHcy with demographic or clinical parameters is not well known. In this study, we examined the prevalence of HHcy and its association with these parameters in a sample of Chinese BD patients. Fasting plasma homocysteine (Hcy) levels were determined in 198 BD inpatients and 84 healthy controls...
August 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29116617/nanoparticulated-polymeric-composites-enfolding-lithium-carbonate-as-brain-drug-in-persuading-depression-an-in-vivo-study
#8
A Anita Margret, V Violet Dhayabaran, A Ganesh Kumar
Lithium carbonate is considered an effective drug against mania and acts as a mood stabilizer. It is found that it enhances antidepressants targeting depression, consequently it is prone to have risk factors that leads to adverse effects. The study is devised in confronting depression under nanoscale by preparing nanocomposites which is a matrix of biopolymer chitosan that encapsulates lithium carbonate by ionic gelation method. This facilitates the drug delivery in a regulated manner targeting the therapeutic action with a limited dosage that lessens the side effects in the course of treatment...
November 7, 2017: Progress in biomaterials
https://www.readbyqxmd.com/read/29112195/face-and-predictive-validity-of-the-clock%C3%AE-19-mouse-as-an-animal-model-for-bipolar-disorder-a-systematic-review
#9
REVIEW
M Kristensen, A A Nierenberg, S D Østergaard
Mice carrying the circadian locomotor output cycles Kaput delta 19 N-ethyl-N-nitrosoure (ENU) mutation (ClockΔ19) are used as an animal model for bipolar disorder (BD). We aimed to systematically review the face validity (phenotypical and pathophysiological resemblance with BD) and predictive validity (responsiveness to treatments used in BD) of this model in adherence with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. We carried out a systematic search of the databases PubMed and Embase, combining search terms covering BD and ClockΔ19...
November 7, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29108803/factor-analysis-of-symptom-dimensions-psychotic-affective-and-obsessive-compulsive-symptoms-in-schizophrenia
#10
Sandeep Grover, Devakshi Dua, Subho Chakrabarti, Ajit Avasthi
AIM: To carryout factor analysis of symptom profile of patients with schizophrenia assessed by using positive and negative syndrome scale (PANSS), Calgary depression rating scale (CDSS), Young mania rating scale (YMRS) and YBOCS checklist. METHODOLOGY: 181 patients of schizophrenia were assessed on PANSS, CDSS, YMRS and YBOCS checklist. RESULTS: Factor analysis of PANSS yielded 3 factor structure (positive, negative, anxiety). When the items of CDSS were added to the PANSS items, total number of factors increased to 4 with depression emerging as a separate factor...
October 23, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29108524/clinical-predictors-of-conversion-to-bipolar-disorder-in-a-prospective-longitudinal-familial-high-risk-sample-focus-on-depressive-features
#11
Andrew Frankland, Gloria Roberts, Ellen Holmes-Preston, Tania Perich, Florence Levy, Rhoshel Lenroot, Dusan Hadzi-Pavlovic, Michael Breakspear, Philip B Mitchell
BACKGROUND: Identifying clinical features that predict conversion to bipolar disorder (BD) in those at high familial risk (HR) would assist in identifying a more focused population for early intervention. METHOD: In total 287 participants aged 12-30 (163 HR with a first-degree relative with BD and 124 controls (CONs)) were followed annually for a median of 5 years. We used the baseline presence of DSM-IV depressive, anxiety, behavioural and substance use disorders, as well as a constellation of specific depressive symptoms (as identified by the Probabilistic Approach to Bipolar Depression) to predict the subsequent development of hypo/manic episodes...
November 7, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29105003/anxiety-irritability-and-agitation-as-indicators-of-bipolar-mania-with-depressive-symptoms-a-post-hoc-analysis-of-two-clinical-trials
#12
Trisha Suppes, Jonas Eberhard, Ole Lemming, Allan H Young, Roger S McIntyre
BACKGROUND: Symptoms of anxiety, irritability, and agitation (AIA) are prevalent among patients with bipolar I disorder (BD-I) mania with depressive symptoms, and could potentially be used to aid physicians in the identification of this more severe form of BD-I. Using data from two clinical trials, the aims of this post hoc analysis were to describe the phenomenology of bipolar mania in terms of AIA and depressive symptoms, and to evaluate the influence of these symptoms on the likelihood of remission during treatment...
November 6, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29102816/leukocyte-telomere-length-variation-in-different-stages-of-schizophrenia
#13
Pawan Kumar Maurya, Lucas Bortolotto Rizzo, Gabriela Xavier, Priscila Farias Tempaku, Vanessa Kiyomi Ota, Marcos L Santoro, Letícia M Spíndola, Patrícia S Moretti, Diego R Mazzotti, Ary Gadelha, Eduardo S Gouvea, Cristiano Noto, Michael Maes, Quirino Cordeiro, Rodrigo A Bressan, Elisa Brietzke, Sintia Iole Belangero
Recent research has demonstrated that telomere maintenance might be a key integrating point for the cumulative effect of genetic and environmental factors in patients with first-episode psychosis (FEP) and schizophrenia (SCZ). Eighty-one participants with antipsychotic-naïve FEP, 173 with SCZ and 438 HC were enrolled in this study. Psychiatric diagnosis was assessed using the Semi-Structured Clinical Interview for DSM-IV Axis-I (SCID-I). The Positive and Negative Syndrome Scale (PANSS), Young Mania Rating Scale (YMRS) and Calgary Depression Scale for Schizophrenia (CDSS) were used to measure symptoms severity...
October 21, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29077650/safety-and-efficacy-of-theta-burst-stimulation-in-the-treatment-of-psychiatric-disorders-a-review-of-the-literature
#14
REVIEW
Fady Rachid
Theta-burst stimulation (TBS) is a form of repetitive transcranial magnetic stimulation and is thought to induce more rapid and longer-lasting effects on synaptic plasticity than conventional repetitive transcranial magnetic stimulation protocols. TBS is being used as an investigational and more recently as a therapeutic tool. The purpose of this review is to describe and discuss the studies that have evaluated the safety and efficacy of this technique in the treatment of various psychiatric disorders such as depression, schizophrenia, obsessive-compulsive disorder, Tourette's disorder, nicotine and cocaine addiction, and pathological gambling...
November 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29077135/-usefulness-of-repetitive-transcranial-magnetic-stimulation-rtms-in-the-treatment-of-bipolar-depression
#15
A de Bruijn, I Tendolkar, J Spijker, M Lochmann van Bennekom, P van Eijndhoven
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) has been found to be an effective technique in the treatment of unipolar depression. However, it is not yet clear whether rTMS is also useful in the treatment of bipolar depression. AIM: To evaluate the available evidence that rTMS is effective in the treatment of bipolar depression. METHOD: Review of available literature (RCTs and open-label studies). RESULTS: We looked closely at four RCTs and four open-label studies...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29073747/psychometric-properties-of-the-hypomania-checklist-32-in-korean-patients-with-mood-disorders
#16
Bo-Hyun Yoon, Jules Angst, Won-Myong Bahk, Hee Ryung Wang, Seung-Oh Bae, Moon-Doo Kim, Young-Eun Jung, Kyung Joon Min, Hwang-Bin Lee, Seunghee Won, Jeongwan Hong, Myong Su Choi, Duk-In Jon, Young Sup Woo
Objective: The aim of this study was to examine the validity of the Korean version of the Hypomania Checklist-32, second revision (HCL-32-R2) in mood disorder patients. Methods: A total of 454 patients who diagnosed as mood disorder according to Structured Clinical Interview for DSM-IV Axis I Disorders, clinician version (SCID-CV) (bipolar disorder [BD] I, n=190; BD-II, n=72; and major depressive disorder [MDD], n=192) completed the Korean module of the HCL-32-R2 (KHCL-32-R2)...
November 30, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29069112/systematic-review-of-recent-guidelines-for-pharmacological-treatments-of-bipolar-disorders-in-adults
#17
Stephen Hammett, Nagy A Youssef
BACKGROUND: To examine the similarities and differences among practice guidelines for managing bipolar disorders (BDs) in adults. METHODS: A literature search in PubMed/Medline was performed using multiple search terms and bibliographies for guidelines from July 2013 (since FDA approval of lurasidone) to June 2017. RESULTS: Six treatment guidelines for BDs in adults were identified. These guidelines showed consensus on first-line treatment of mania (moodstabilizer and/or an antipsychotic), and most first-line medications for bipolar depression...
November 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/29067671/a-review-of-asenapine-in-the-treatment-of-bipolar-disorder
#18
REVIEW
Eduard Vieta, José Manuel Montes
Bipolar disorder places a significant burden on the affected individuals, their family, healthcare systems and the overall economy. More treatment options are needed, especially those with better efficacy and tolerability. Asenapine is a second-generation antipsychotic approved in Europe (brand name Sycrest(®)) for the treatment of moderate-to-severe manic episodes associated with bipolar I disorder in adults, and in the US (brand name Saphris(®)) for the treatment of manic or mixed episodes of bipolar I disorder in adults and children aged 10-17 years...
October 24, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29063217/quetiapine-induced-hypomania-and-its-association-with-quetiapine-norquetiapine-plasma-concentrations-a-case-series-of-bipolar-type-2-patients
#19
C Rovera, C M Esposito, V Ciappolino, D Cattaneo, S Baldelli, E Clementi, A C Altamura, M Buoli
International guidelines consider quetiapine at medium doses (300-400 mg/day) as valid options for the treatment of bipolar depression for the supposed lower risk of a switch to hypomania/mania than antidepressants. Norquetiapine is an active metabolite with antidepressant action. We describe three cases of induced hypomania in bipolar type 2 subjects who received quetiapine extended-release monotherapy (300 mg/day) for a mild/moderate major depressive episode. Quetiapine and norquetiapine plasma concentrations were measured after 1 week of treatment...
October 23, 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29062369/evaluation-of-bipolar-disorder-in-several-relapses-over-time-using-generalized-estimating-equations
#20
Payam Amini, Roya Najafi-Vosough, Ali Ghaleiha, Hossein Mahjub
Objective: Bipolar disorder is defined as a common and severe chronic disorder that causes several problems in a person's psychosocial functioning. This study aimed at modeling the development of bipolar disorder episodes using its determinant risk factors over time. Method: This retrospective cohort study was conducted in Hamadan province, the West of Iran, from April 2008 to September 2014. In this study, 124 patients with bipolar disorder (both Type I and Type II) participated. All patients had experienced 4 relapses...
July 2017: Iranian Journal of Psychiatry
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