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https://www.readbyqxmd.com/read/29329056/subjective-and-objective-sleep-discrepancy-in-symptomatic-bipolar-disorder-compared-to-healthy-controls
#1
Venkatesh Krishnamurthy, Dahlia Mukherjee, Aubrey Reider, Scott Seaman, Gagan Singh, Julio Fernandez-Mendoza, Erika Saunders
BACKGROUND: Bipolar disorder (BD) is associated with sleep misperception. The objective of this study was to investigate the correlation between subjective and objective measures of sleep in persons with symptomatic bipolar disorder (BDS) compared to healthy controls (HC). METHODS: We studied 24 BDS and 30 HC subjects similar in age, race and sex. Subjective sleep was measured with Pittsburgh Sleep Quality Index (PSQI) and objective sleep with 7-days of actigraphy...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29325238/psychometrics-of-the-self-report-concise-associated-symptoms-tracking-scale-cast-sr-results-from-the-stride-ctn-0037-study
#2
Joseph M Trombello, Michael O Killian, Allen Liao, Katherine Sanchez, Tracy L Greer, Robrina Walker, Bruce Grannemann, Chad D Rethorst, Thomas Carmody, Madhukar H Trivedi
OBJECTIVE: The self-report Concise Associated Symptoms Tracking Scale (CAST-SR) was developed to track mania, irritability, anxiety, panic, and insomnia symptoms among depressed outpatients receiving antidepressant medication. Given the overlap between these domains, depression, and stimulant use disorders, we reexamined CAST-SR psychometrics in a novel sample: individuals with stimulant use disorder receiving aerobic exercise or health education interventions. METHODS: Using the subsample of stimulant-dependent (following DSM-IV criteria) individuals prescribed antidepressants (N = 124) from the multisite Stimulant Reduction Intervention Using Dosed Exercise (CTN-0037) trial (total sample N = 302), conducted July 2010 to February 2013, we analyzed CAST-SR data collected at the first assessment after participant's discharge from residential treatment...
January 9, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29303919/efficacy-and-safety-of-intensive-transcranial-magnetic-stimulation
#3
Tomas Sverak, Libor Ustohal
Repetitive transcranial magnetic stimulation (rTMS) is customarily applied on a daily basis for prolonged periods of time for the treatment of psychiatric diseases. The process is demanding in terms of staff and patient time, and the onset of the effect is slow. Recently, intensive rTMS protocols have been introduced in which stimulation is applied to the same area more than once a day with a higher than standard number of pulses. This article reviews 16 articles to determine the safety and efficacy of such protocols...
January 2018: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/29286593/circadian-rhythm-sleep-wake-disorders-predict-shorter-time-to-relapse-of-mood-episodes-in-euthymic-patients-with-bipolar-disorder-a-prospective-48-week-study
#4
Yoshikazu Takaesu, Yuichi Inoue, Kotaro Ono, Akiko Murakoshi, Kunihiro Futenma, Yoko Komada, Takeshi Inoue
OBJECTIVE: Circadian rhythm dysfunction has been considered to be common in bipolar disorder (BD) and plays an important role in mood dysregulation in this disorder. However, no study has investigated whether circadian rhythm dysfunction would affect the clinical course of BD. The aim of this study was to test the hypothesis that circadian rhythm dysfunction could be a predictor of relapse in euthymic BD patients. METHODS: One hundred four euthymic outpatients with BD diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), participated in this prospective follow-up study from August 2014 to April 2015...
December 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29284814/a-rare-presentation-of-a-case-of-obsessive-compulsive-disorder-comorbid-with-bipolar-affective-disorder
#5
Nimmy Chandran, Arpit Parmar, Koushik Sinha Deb
Obsessive-compulsive disorder (OCD) is a chronic illness with waxing and waning course. OCD is not uncommonly found to be comorbid with bipolar affective disorder (BPAD). The course and prognosis of OCD have distinctive features in such cases. Only rarely symptoms of OCD emerge during mania in such individuals. We hereby report a very unusual case of OCD comorbid with BPAD in which obsession and compulsion symptoms occurred only during manic episodes with complete remission during periods between manic episodes (including during depressive episodes)...
November 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29283064/glycogen-synthase-kinase-3%C3%AE-as-a-putative-therapeutic-target-for-bipolar-disorder
#6
Manoj P Dandekar, Samira S Valvassori, Gustavo Colombo Dal-Pont, Joao L DeQuevedo
BACKGROUND: Bipolar disorder (BD) is a debilitating mental ailment characterized by recurrent episodes of mania and depression. Primary mood-stabilizing drugs like lithium and valproate alleviate the hypomanic or mild to moderate manic episodes in patients with BD. One of the extensively studied underlying mechanisms for these pharmacological interventions is inhibition of intracellular signaling cascades associated with glycogen synthase kinase-3 beta (GSK-3β), a multi-functional serine-threonine kinase...
December 27, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29280686/state-dependent-alterations-of-lipid-profiles-in-patients-with-bipolar-disorder
#7
Yu-Jui Huang, Shang-Ying Tsai, Kuo-Hsuan Chung, Pao-Huan Chen, Shou-Hung Huang, Chian-Jue Kuo
Objective Serum lipid levels may be associated with the affective severity of bipolar disorder, but data on lipid profiles in Asian patients with bipolar disorder and the lipid alterations in different states of opposite polarities are scant. We investigated the lipid profiles of patients in the acute affective, partial, and full remission state in bipolar mania and depression. Methods The physically healthy patients aged between 18 and 45 years with bipolar I disorder, as well as age-matched healthy normal controls were enrolled...
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29258468/variability-of-activity-patterns-across-mood-disorders-and-time-of-day
#8
Karoline Krane-Gartiser, Arne E Vaaler, Ole Bernt Fasmer, Kjetil Sørensen, Gunnar Morken, Jan Scott
BACKGROUND: Few actigraphy studies in mood disorders have simultaneously included unipolar (UP) and bipolar (BD) depression or BD mixed states as a separate subgroup from mania. This study compared objectively measured activity in UP, BD depression, mania and mixed states and examined if patterns differed according to time of day and/or diagnostic group. METHODS: Eighty -eight acutely admitted inpatients with mood disorders (52 UP; 18 mania; 12 BD depression; 6 mixed states) underwent 24 hours of actigraphy monitoring...
December 19, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29249805/clustered-repetitive-transcranial-magnetic-stimulation-for-the-prevention-of-depressive-relapse-recurrence-a-randomized-controlled-trial
#9
Hua-Ning Wang, Xiao-Xia Wang, Rui-Guo Zhang, Ying Wang, Min Cai, Ya-Hong Zhang, Run-Zhu Sun, Li Guo, Yu-Ting Qiao, Jun-Chang Liu, Hong He, Zhong-Heng Wang, Yu-Chen Wan, Qing-Rong Tan, Zhang-Jin Zhang
Repetitive transcranial magnetic stimulation (rTMS) may have the potential to prevent depressive relapse. This assessor-blinded, randomized controlled study was designed to evaluate the efficacy and safety of rTMS as a mono- and combination therapy in the prevention of depressive relapse/recurrence. A total of 281 depressed patients who had achieved stable full or partial remission on a 6-month antidepressant (ADP) run-in treatment were randomly assigned to an rTMS (n = 91), ADP (n = 108), or combined (rTMS + ADP, n = 82) treatment group for 12 months...
December 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29248821/psychometric-properties-of-the-well-being-index-who-5-spanish-version-in-a-sample-of-euthymic-patients-with-bipolar-disorder
#10
C M Bonnín, L N Yatham, E E Michalak, A Martínez-Arán, T Dhanoa, I Torres, C Santos-Pascual, E Valls, A F Carvalho, J Sánchez-Moreno, M Valentí, I Grande, D Hidalgo-Mazzei, E Vieta, M Reinares
BACKGROUND: The concept of well-being which focuses on positive emotions has received increased research attention. However, a consensus definition of this term is lacking. The Well-Being Index scale (WHO-5) is a generic, self-report scale that contains five Likert-type items to evaluate psychological well-being. This construct may provide a relevant outcome in bipolar disorder (BD) research and care beyond the rating of mood symptoms. Thus, in the current study, the psychometric properties of the WHO-5 Spanish version were assessed in a sample of euthymic patients with BD...
December 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29245092/predictors-of-hospitalization-length-of-stay-among-re-admitted-treatment-resistant-bipolar-disorder-inpatients
#11
M Fornaro, F Iasevoli, S Novello, A Fusco, A Anastasia, D De Berardis, A Valchera, A de Bartolomeis
BACKGROUND: Hospitalization accounts for significant health care resource utilization for treatment-resistant Bipolar Disorder (BD), especially among frequent users of acute inpatient psychiatric units. Appraisal of the clinical features and predictive role of selected variables is therefore crucial in such population, representing the aim of the present research. METHODS: A hundred and nineteen BD inpatients with an established history of pharmacological treatment resistance for either mania or bipolar depression were classified as long hospitalization cases (LOS+) and their controls and compared against each other for a number of demographic, clinical, and psychopathological features...
December 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29244906/finding-treatment-resistant-depression-in-real-world-data-how-a-data-driven-approach-compares-with-expert-based-heuristics
#12
M Soledad Cepeda, Jenna Reps, Daniel Fife, Clair Blacketer, Paul Stang, Patrick Ryan
BACKGROUND: Depression that does not respond to antidepressants is treatment-resistant depression (TRD). TRD definitions include assessments of treatment response, dose and duration, and implementing these definitions in claims databases can be challenging. We built a data-driven TRD definition and evaluated its performance. METHODS: We included adults with depression, ≥1 antidepressant, and no diagnosis of mania, dementia, or psychosis. Subjects were stratified into those with and without proxy for TRD...
December 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29228982/electroconvulsive-therapy-for-manic-state-with-mixed-and-psychotic-features-in-a-teenager-with-bipolar-disorder-and-comorbid-episodic-obsessive-compulsive-disorder-a-case-report
#13
Olof Rask, Klara Suneson, Eva Holmström, Beata Bäckström, Björn Axel Johansson
BACKGROUND: Comorbidity of bipolar disorder and obsessive-compulsive disorder is common in adolescence. Obsessive-compulsive disorder symptoms may be episodic and secondary to alterations in mood, and display specific features. Management of pediatric bipolar disorder-obsessive-compulsive disorder is challenging, as pharmacotherapy of obsessive-compulsive disorder may induce or exacerbate manic episodes and there is limited evidence of treatment efficacy. Electroconvulsive therapy is sparsely used in children and adolescents, but is documented to be a safe and efficacious intervention in adults with bipolar disorder...
December 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29228943/reconsidering-the-prognosis-of-major-depressive-disorder-across-diagnostic-boundaries-full-recovery-is-the-exception-rather-than-the-rule
#14
Judith Verduijn, Josine E Verhoeven, Yuri Milaneschi, Robert A Schoevers, Albert M van Hemert, Aartjan T F Beekman, Brenda W J H Penninx
BACKGROUND: Major depressive disorder (MDD) is often handled as an episodic and isolated disorder, resulting in an optimistic view about its prognosis. Herein, we test the idea that the prognosis of MDD changes if we vary the perspective in terms of (1) a longer time frame and (2) a broader diagnostic conceptualisation including dysthymia, (hypo)mania and anxiety disorders as relevant outcomes. METHODS: Patients with current MDD at baseline (n = 903) and available 2-, 4-, and/or 6-year follow-up assessments were selected from the Netherlands Study of Depression and Anxiety, a psychiatric cohort study...
December 12, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29227012/superior-anti-suicidal-effects-of-electroconvulsive-therapy-in-unipolar-disorder-and-bipolar-depression
#15
Chih-Sung Liang, Chi-Hsiang Chung, Pei-Shen Ho, Chia-Kuang Tsai, Wu-Chien Chien
OBJECTIVES: Electroconvulsive therapy (ECT) has long been believed to reduce suicidal tendencies in patients with affective disorders; however, ECT recipients, who constitute the most severely ill and suicidal patients, are not eligible to participate in head-to-head randomized controlled trials. Large-scale studies are required to investigate the anti-suicidal effects of ECT vs psychopharmacotherapy. METHODS: A nationwide retrospective cohort study design was used...
December 11, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29209876/mentalization-deficit-in-bipolar-patients-during-an-acute-depressive-and-manic-episode-association-with-cognitive-functions
#16
Anna Bodnar, Janusz K Rybakowski
BACKGROUND: A number of studies in bipolar patients have shown a deficit in mentalization (theory of mind), one of the main aspects of social cognition. The aim of current study was to assess both cognitive and affective mentalization in well-defined groups of depressed and manic bipolar patients, compared to healthy control subjects, using a battery of tests measuring mentalization processes. The second aim was to investigate a possible relationship between cognitive and affective mentalization and cognitive functions in bipolar patients during a depressive and manic episode...
December 6, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29197711/prevalence-of-sleep-disorders-and-severity-of-insomnia-in-psychiatric-outpatients-attending-a-tertiary-level-mental-health-care-facility-in-punjab-india
#17
Gargi Mondal, Vikrant Bajaj, B L Goyal, Nirmalya Mukherjee
BACKGROUND: Sleep disorders are frequently associated with psychiatric disorders and can be both cause and effect of the same. AIM: To study the prevalence of sleep disorders and the severity of insomnia in psychiatric outpatients. METHODS: 500 patients were randomly selected using purposive sampling from patients attending a tertiary level mental health care facility were evaluated for the presence of any sleep disorder along with their sleep quality...
November 27, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29195773/cognitive-deficits-in-bipolar-disorders-implications-for-emotion
#18
REVIEW
Isabela M M Lima, Andrew D Peckham, Sheri L Johnson
Prominent cognitive deficits have been documented in bipolar disorder, and multiple studies suggest that these deficits can be observed among non-affected first-degree relatives of those with bipolar disorder. Although there is variability in the degree of cognitive deficits, these deficits are robustly relevant for functional outcomes. A separate literature documents clear difficulties in emotionality, emotion regulation, and emotion-relevant impulsivity within bipolar disorder, and demonstrates that these emotion-relevant variables are also central to outcome...
November 21, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29186986/steroid-induced-mental-disorders-in-cancer-patients-a-systematic-review
#19
Muhammad Fahmi Ismail, Clianna Lavelle, Eugene M Cassidy
Corticosteroids are a central part of many cancer treatment regimens. Neuropsychiatric toxicity has complicated their use, including an association with a spectrum of symptoms, from insomnia, cognitive impairment and mood symptoms, to severe mental disorders, including mania, psychosis and severe depression. Although steroid-induced mental disorders were first reported in medicine more than 60 years ago, there is a dearth of evidence available to date on optimal treatment and prevention to guide cancer clinicians...
November 30, 2017: Future Oncology
https://www.readbyqxmd.com/read/29182724/worsening-anxiety-irritability-insomnia-or-panic-predicts-poorer-antidepressant-treatment-outcomes-clinical-utility-and-validation-of-the-concise-associated-symptom-tracking-cast-scale
#20
Manish K Jha, Abu Minhajuddin, Charles South, A John Rush, Madhukar H Trivedi
Background: We report on the psychometric properties of the 16-item Concise Associated Symptom Tracking Scale (CAST) self-report scale and its clinical utility. Methods: The five-domain (irritability, anxiety, mania, insomnia, and panic) structure of CAST was validated with confirmatory factor analysis (CFA) in Combining Medications to Enhance Depression Outcomes trial participants at baseline (n=664). Correlations with other clinical measures was used for convergent and divergent validity...
November 22, 2017: International Journal of Neuropsychopharmacology
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