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https://www.readbyqxmd.com/read/28533149/prevalence-and-characteristics-of-catatonia-on-admission-to-an-acute-geriatric-psychiatry-ward
#1
Jorge Cuevas-Esteban, Maria Iglesias-González, Maria Rubio-Valera, Jordi Serra-Mestres, Antoni Serrano, Luisa Baladon
BACKGROUND: This study aims to describe the prevalence of catatonia in a population of older acute psychiatric inpatients according to different diagnostic criteria. Secondary objectives are: to compare the catatonic symptom profile, prevalence, and severity, in respect to the underlying aetiology, and to evaluate the association between catatonic and somatic comorbidity. METHODS: The study included 106 patients admitted to an acute geriatric psychiatry ward. Catatonia was assessed using the Bush Francis Catatonia Rating Scale (BFCRS)...
May 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28531264/cariprazine-exhibits-anxiolytic-and-dopamine-d3-receptor-dependent-antidepressant-effects-in-the-chronic-stress-model
#2
Vanya Duric, Mounira Banasr, Tina Franklin, Ashley Lepack, Nika Adham, Béla Kiss, István Gyertyán, Ronald S Duman
Background: Cariprazine, a D3-preferring dopamine D2/D3 receptor partial agonist, is a new antipsychotic drug recently approved in the US for the treatment of schizophrenia and bipolar mania. We recently demonstrated that cariprazine also has significant anti-anhedonic-like effects in rats subjected to chronic stress; however, the exact mechanism of action for cariprazine's antidepressant-like properties is not known. Thus, in this study we examined whether the effects of cariprazine are mediated by dopamine D3 receptors...
May 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28529394/positive-emotion-specificity-and-mood-symptoms-in-an-adolescent-outpatient-sample
#3
June Gruber, Anna Van Meter, Kirsten E Gilbert, Eric A Youngstrom, Jennifer Kogos Youngstrom, Norah C Feeny, Robert L Findling
Research on positive emotion disturbance has gained increasing attention, yet it is not clear which specific positive emotions are affected by mood symptoms, particularly during the critical period of adolescence. This is especially pertinent for identifying potential endophenotypic markers associated with mood disorder onset and course. The present study examined self-reported discrete positive and negative emotions in association with clinician-rated manic and depressive mood symptoms in a clinically and demographically diverse group of 401 outpatient adolescents between 11-18 years of age...
June 2017: Cognitive Therapy and Research
https://www.readbyqxmd.com/read/28528241/peripheral-zinc-and-neopterin-concentrations-are-associated-with-mood-severity-in-bipolar-disorder-in-a-gender-specific-manner
#4
Caitlin E Millett, Dahlia Mukherjee, Aubrey Reider, Adem Can, Maureen Groer, Dietmar Fuchs, Teodor T Postolache, Shannon L Kelleher, Erika F H Saunders
Bipolar disorder (BD) is a recurrent, episodic mood disorder for which there are no current diagnostic, prognostic or theranostic biomarkers. Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature. Given gender differences in clinical presentation of BD and in inflammatory processes, we aimed to explore the interaction between gender and immune biomarkers to predict mood severity in BD. Participants with DSM IV BD I and II were recruited through the Pennsylvania Psychiatric Institute during an acute mood episode...
May 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28525775/the-association-between-systemic-lupus-erythematosus-and-bipolar-disorder%C3%A2-%C3%A2-a-big-data-analysis
#5
S Tiosano, Z Nir, O Gendelman, D Comaneshter, H Amital, A D Cohen, D Amital
BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease that has a wide variety of physical manifestations, including neuropsychiatric features. Bipolar disorder (BD) is a chronic, episodic illness, that may present as depression or as mania. The objective of this study was to investigate the association between SLE and BD using big data analysis methods. METHODS: Patients with SLE were compared with age- and sex-matched controls regarding the prevalence of BD in a cross-sectional study...
April 4, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28525601/too-fast-or-too-slow-time-and-neuronal-variability-in-bipolar-disorder-a-combined-theoretical-and-empirical-investigation
#6
Georg Northoff, Paola Magioncalda, Matteo Martino, Hsin-Chien Lee, Ying-Chi Tseng, Timothy Lane
Time is an essential feature in bipolar disorder (BP). Manic and depressed BP patients perceive the speed of time as either too fast or too slow. The present article combines theoretical and empirical approaches to integrate phenomenological, psychological, and neuroscientific accounts of abnormal time perception in BP. Phenomenology distinguishes between perception of inner time, ie, self-time, and outer time, ie, world-time, that desynchronize or dissociate from each other in BP: inner time speed is abnormally slow (as in depression) or fast (as in mania) and, by taking on the role as default-mode function, impacts and modulates the perception of outer time speed in an opposite way, ie, as too fast in depression and too slow in mania...
May 19, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28523431/the-dsm-5-self-rated-level-1-cross-cutting-symptom-measure-as-a-screening-tool
#7
Leo Bastiaens, James Galus
The DSM-5 Self-Rated Level 1 Cross-Cutting Symptom Measure was developed to aid clinicians with a dimensional assessment of psychopathology; however, this measure resembles a screening tool for several symptomatic domains. The objective of the current study was to examine the basic parameters of sensitivity, specificity, positive and negative predictive power of the measure as a screening tool. One hundred and fifty patients in a correctional community center filled out the measure prior to a psychiatric evaluation, including the Mini International Neuropsychiatric Interview screen...
May 19, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28507774/footnotes-to-kraepelin-changes-in-the-classification-of-mood-disorders-with-dsm-5
#8
EDITORIAL
Nicola J Kalk, Allan H Young
SUMMARY: Reliable diagnosis of mood disorders continues to pose a challenge. This is surprising because they have been recognised clinically since classical times. Mood disorders are also common: major depressive disorder affects nearly 300 million people worldwide and bipolar affective disorder nearly 60 million and they are a major cause of disability. Nonetheless, the reliability trials of the updated Diagnostic and Statistical Manual, Fifth Edition (DSM-5) found that the reliability of the diagnosis of major depressive disorder was in the 'questionable' range...
May 2017: BJPsych Open
https://www.readbyqxmd.com/read/28503114/antidepressant-induced-dopamine-receptor-dysregulation-a-valid-animal-model-of-manic-depressive-illness
#9
REVIEW
Francesca Demontis, Francesca Serra, Gino Serra
BACKGROUND: Mania seems to be associated with an increased dopamine (DA) transmission. Antidepressant treatments can induce mania in humans and potentiated DA transmission in animals, by sensitizing DA D2 receptors in the mesolimbic system. We have suggested that the sensitization of D2 receptors may be responsible of antidepressant-induced mania. This review aims to report the experimental evidence that led to the hypothesis that antidepressant-induced DA receptors dysregulation can be considered an animal model of bipolar disorder...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28503113/who-s-the-leader-mania-or-depression-predominant-polarity-and-alcohol-polysubstance-use-in-bipolar-disorders
#10
Delfina Janiri, Marco Di Nicola, Giovanni Martinotti, Luigi Janiri
BACKGROUND: Predominant polarity characterises patients who mainly manifest recurrences of depression or mania/hypomania. Alcohol use disorder (AUD) and polysubstance use (PSU), which often complicate bipolar disorder (BD) and affect its clinical course, can influence predominant polarity. Nevertheless, previous studies have not clarified if BD patients differ in predominant polarity from BD patients with substance use disorder (SUD) comorbidity. OBJECTIVE: The aim of this study was to compare predominant polarity between BD without SUD, BD with AUD and BD with PSU...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28503112/athanasios-koukopoulos-psychiatry-the-primacy-of-mania-and-the-limits-of-antidepressants
#11
REVIEW
S Nassir Ghaemi, Paul A Vohringer
BACKGROUND: Athanasios Koukopoulos provided a radical model for understanding depressive and manic conditions. OBJECTIVE: To review, explain, and analyze Koukopoulos' concept of the primacy of mania, with special attention to the role of antidepressants. METHOD: A conceptual review of Koukopoulos' writings and lectures on this topic is given. RESULTS: Koukopoulos held that depressive states are caused by manic states; the former do not occur without the latter...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28503111/free-interval-duration-clinical-evidence-of-the-primary-role-of-excitement-in-bipolar-disorder
#12
Gabriele Sani, Alessio Simonetti, Daniela Reginaldi, Alexia E Koukopoulos, Antonio Del Casale, Giovanni Manfredi, Georgios D Kotzalidis, Paolo Girardi
BACKGROUND: Cyclicity is the essential feature of Bipolar disorder, but the effect of different cycle patterns on the clinical features is poorly understood. Moreover, no studies investigated the relationship between mania and depression inside the manic-depressive cycle. OBJECTIVE: The aim of this study is to verify the presence of a relationship between the manic and the depressive phase during the course of bipolar disorder. METHOD: 160 consecutive patients with BD type I were recruited and followed for a mean period of 10 years...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28503110/pediatric-mania-the-controversy-between-euphoria-and-irritability
#13
Giulia Serra, Mai Uchida, Claudia Battaglia, Maria Pia Casini, Lavinia De Chiara, Joseph Biederman, Stefano Vicari, Janet Wozniak
Pediatric Bipolar Disorder (BD) is a highly morbid pediatric psychiatric disease, consistently associated with family psychiatric history of mood disorders and associated with high levels of morbidity and disability and with a great risk of suicide. While there is a general consensus on the symptomatology of depression in childhood, the phenomenology of pediatric mania is still highly debated and the course and long-term outcome of pediatric BD still need to be clarified. We reviewed the available studies on the phenomenology of pediatric mania with the aim of summarizing the prevalence, demographics, clinical correlates and course of these two types of pediatric mania...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28503107/the-role-of-electroconvulsive-therapy-ect-in-bipolar-disorder-effectiveness-in-522-patients-with-bipolar-depression-mixed-state-mania-and-catatonic-features
#14
Giulio Perugi, Pierpaolo Medda, Cristina Toni, Michela Giorgi Mariani, Chiara Socci, Mauro Mauri
OBJECTIVE: We evaluated the effectiveness of Electroconvulsive Therapy (ECT) in the treatment of Bipolar Disorder (BD) in a large sample of bipolar patients with drug resistant depression, mania, mixed state and catatonic features. METHOD: 522 consecutive patients with DSM-IV-TR BD were evaluated prior to and after the ECT course. Responders and nonresponders were compared in subsamples of depressed and mixed patients. Descriptive analyses were reported for patients with mania and with catatonic features...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28503106/depression-and-mania-in-bipolar-disorder
#15
Leonardo Tondo, Gustavo H Vázquez, Ross J Baldessarini
BACKGROUND: Episode duration, recurrence rates, and time spent in manic and depressive phases of bipolar disorder (BD) is not well defined for subtypes of the disorder. METHODS: We reviewed the course, timing, and duration of episodes of mania and depression among 1130 clinically treated DSM-IV-TR BD patients of various types, and compared duration and rates as well as total proportion of time in depressive versus manic episodes during 16.7 average years at risk...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28503105/neurobiological-evidence-for-the-primacy-of-mania-hypothesis
#16
REVIEW
Georgios D Kotzalidis, Chiara Rapinesi, Valeria Savoja, Ilaria Cuomo, Alessio Simonetti, Elisa Ambrosi, Isabella Panaccione, Silvia Gubbini, Pietro De Rossi, Lavinia De Chiara, Delfina Janiri, Gabriele Sani, Alexia E Koukopoulos, Giovanni Manfredi, Flavia Napoletano, Matteo Caloro, Lucia Pancheri, Antonella Puzella, Gemma Callovini, Gloria Angeletti, Antonio Del Casale
BACKGROUND: Athanasios Koukopoulos proposed the primacy of mania hypothesis (PoM) in a 2006 book chapter and later, in two peer-reviewed papers with Nassir Ghaemi and other collaborators. This hypothesis supports that in bipolar disorder, mania leads to depression, while depression does not lead to mania. OBJECTIVE: To identify evidence in literature that supports or falsifies this hypothesis. METHOD: We searched the medical literature (PubMed, Embase, PsycINFO, and the Cochrane Library) for peer-reviewed papers on the primacy of mania, the default mode function of the brain in normal people and in bipolar disorder patients, and on illusion superiority until 6 June, 2016...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28496498/effectiveness-of-psychoeducational-group-training-on-quality-of-life-and-recurrence-of-patients-with-bipolar-disorder
#17
Farhad Faridhosseini, Mehdi Baniasadi, Mohammad Reza Fayyazi Bordbar, Meysam Pourgholami, Samira Ahrari, Negar Asgharipour
Objective: Bipolar disorder (BD) is a disabling psychiatric disorder with frequent recurrences. Besides pharmacotherapy, psychoeducation could be helpful in reducing symptoms as well as recurrence of this disorder, leading to improvement of patients' quality of life. This study aimed at investigating the effectiveness of a culturally adjusted structured program for training Iranian BD patients. Method: In a 6-month course (spring and summer 2014), 24 BD patients, visiting the outpatient clinic of Ibn-Sina Hospital in Mashhad and experiencing euthymic phase, were allocated in to 2 groups of intervention and control...
January 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/28494779/blood-homocysteine-concentration-and-mood-disorders-with-mixed-features-among-patients-with-alcohol-use-disorder
#18
Francesco Oliva, Maurizio Coppola, Raffaella Mondola, Daniele Ascheri, Francesco Cuniberti, Gabriele Nibbio, Rocco Luigi Picci
BACKGROUND: Blood homocysteine concentration (BHC) is higher in patients with alcohol use disorder (AUD). Previous studies have found a relationship between depressive symptoms severity and BHC in AUD patients and recently some authors have found high BHC among patients with bipolar disorder, both during manic and depressive episodes and in euthymic state. However, BHC in patients with mixed mood episode has not yet been investigated. The aim of this study was to evaluate the BHC of patients with AUD and mixed mood episode...
May 12, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28493655/development-of-a-computerized-adaptive-test-suicide-scale-the-cat-ss
#19
Robert D Gibbons, David Kupfer, Ellen Frank, Tara Moore, David G Beiser, Edwin D Boudreaux
OBJECTIVE: Current suicide risk screening and measurement are inefficient, have limited measurement precision, and focus entirely on suicide-related items. For this study, a psychometric harmonization between related suicide, depression, and anxiety symptom domains that provides a more balanced and complete spectrum of suicidal symptomatology was developed. The objective of this article is to describe the results of the early stages of computerized adaptive testing development for a suicide scale and pave the way for the final stage of validation...
May 9, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28491042/disentangling-working-memory-functioning-in-mood-states-of-bipolar-disorder-a-systematic-review
#20
REVIEW
Carolina Soraggi-Frez, Flávia H Santos, Pedro B Albuquerque, Leandro F Malloy-Diniz
Working memory (WM) deficits are often reported in patients with Bipolar Disorder (BD). However, it is not clear about the nature of these WM deficits (update or serial order processes) and their association with each BD states (euthymic, mania, and depressive). This review investigated the association between BD patient's states and the functioning of WM components. For this purpose, we carried out a systematic review fulfilling a search in the databases Medline, Scopus, SciELO, and Web of Science using specific terms in the abstracts of the articles that generated 212 outcomes in the restricted period from 2005 to 2016...
2017: Frontiers in Psychology
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