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https://www.readbyqxmd.com/read/28804990/characterizing-the-experience-of-auditory-verbal-hallucinations-and-accompanying-delusions-in-individuals-with-a-diagnosis-of-bipolar-disorder-a-systematic-review
#1
REVIEW
L M Smith, L C Johns, Rlc Mitchell
OBJECTIVES: The aim of the current study was to inform ongoing attempts to identify clinically meaningful subcategories of auditory verbal hallucination (AVH), and to evaluate evidence that might pertain to the suitability of current psychological interventions for people with bipolar disorder (BD) who experience psychotic symptoms. METHODS: A comprehensive synthesis of findings on the phenomenology of AVH and delusions in BD is included, alongside a critical review of clinical and cognitive correlates...
August 14, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28803094/brief-psychoeducation-for-bipolar-disorder-evaluation-of-trophic-factors-serum-levels-in-young-adults
#2
Carolina David Wiener, Mariane Lopez Molina, Fernanda Pedrotti Moreira, Miguel Bezerra Dos Passos, Karen Jansen, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Jean Pierre Oses
The aim of this study was to evaluate the impact of psychoeducation in serum levels of BDNF, NGF and GDNF in young adults presenting bipolar disorder (BD). This is a randomized clinical trial including 39 young adults (18-29 years) diagnosed with BD through the Structured Clinical Interview for DSM-IV (SCID-CV). Participants were randomized in two treatment groups: usual treatment (medication) and combined intervention (medication plus psychoeducation). Depressive symptoms were assessed using the Hamilton Depression Rating Scale (HDRS) and severity of manic and hypomanic symptoms was evaluated through the Young Mania Rating Scale (YMRS)...
July 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28802190/alcohol-use-and-bipolar-disorders-risk-factors-associated-with-their-co-occurrence-and-sequence-of-onsets
#3
Jean-Michel Azorin, Léa C Perret, Eric Fakra, Sébastien Tassy, Nicolas Simon, Marc Adida, Raoul Belzeaux
BACKGROUND: Little is known about the sequence of onsets in patients affected by comorbid alcohol use and bipolar disorder. This study examines the risk factors associated with their co-occurrence and order of onset. METHOD: The demographic, clinical, and temperament characteristics as well as the course of illness were analyzed within our sample of 1090 DSM-IV bipolar I manic patients. Our sample was categorized according to the presence of comorbid alcohol use disorder and the sequence of onsets of bipolar and alcohol use disorders i...
August 3, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28797561/self-reported-psychosis-like-experiences-in-patients-with-mood-disorders
#4
I Baryshnikov, J Suvisaari, K Aaltonen, M Koivisto, T Melartin, P Näätänen, K Suominen, B Karpov, M Heikkinen, J Oksanen, T Paunio, G Joffe, E Isometsä
BACKGROUND: Self-reported psychosis-like experiences (PEs) may be common in patients with mood disorders, but their clinical correlates are not well known. We investigated their prevalence and relationships with self-reported symptoms of depression, mania, anxiety, borderline (BPD) and schizotypal (SPD) personality disorders among psychiatric patients with mood disorders. METHODS: The Community Assessment of Psychic Experiences (CAPE-42), Mood Disorder Questionnaire (MDQ), McLean Screening Instrument (MSI), The Beck Depressive Inventory (BDI), Overall Anxiety Severity and Impairment Scale (OASIS) and Schizotypal Personality Questionnaire-Brief form (SPQ-B) were filled in by patients with mood disorders (n=282) from specialized care...
February 3, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28783937/plasma-levels-of-tumor-necrosis-factor-superfamily-molecules-are-increased-in-bipolar-disorder
#5
Izabela G Barbosa, Gabriela Neves Vaz, Natalia Pessoa Rocha, Rodrigo Machado-Vieira, Marcio Rogerio Diniz Ventura, Rodrigo B Huguet, Moises E Bauer, Michael Berk, Antônio L Teixeira
Objective: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD. Methods: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28777984/comorbid-sleep-disorders-and-suicide-risk-among-children-and-adolescents-with-bipolar-disorder
#6
Ian H Stanley, Melanie A Hom, Joan L Luby, Paramjit T Joshi, Karen D Wagner, Graham J Emslie, John T Walkup, David A Axelson, Thomas E Joiner
Children and adolescents with bipolar disorder are at increased risk for suicide. Sleep disturbances are common among youth with bipolar disorder and are also independently implicated in suicide risk; thus, comorbid sleep disorders may amplify suicide risk in this clinical population. This study examined the effects of comorbid sleep disorders on suicide risk among youth with bipolar disorder. We conducted secondary analyses of baseline data from the Treatment of Early Age Mania (TEAM) study, a randomized controlled trial of individuals aged 6-15 years (mean ± SD = 10...
July 29, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28777983/vitamin-d-supplementation-in-bipolar-depression-a-double-blind-placebo-controlled-trial
#7
Wendy K Marsh, Jessica L Penny, Anthony J Rothschild
OBJECTIVE: Bipolar depression is difficult to treat. Vitamin D supplementation is well tolerated and may improve mood via its neurotransmitter synthesis regulation, nerve growth factor enhancement and antioxidant properties. Vitamin D adjunct reduces unipolar depression, but has not been tried in bipolar depression. METHODS: 18-70yos with DSM IV bipolar depression and Vitamin D deficiency (<30 ng/ml) were randomized in a controlled double blind trial of 5000IU Vitamin D3 po qday supplementation versus placebo for twelve weeks...
July 22, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28777104/mood-stabilizing-effects-of-rapamycin-and-its-analog-temsirolimus-relevance-to-autophagy
#8
Nirit Z Kara, Shlomit Flaisher-Grinberg, Grant W Anderson, Galila Agam, Haim Einat
Accumulated data support a relationship between mood disorders and cellular plasticity and resilience, some suggesting relevance to autophagy. Our previous data show that pharmacological enhancement of autophagy results in antidepressant-like effects in mice. The current study was designed to further examine the effects of autophagy enhancement on mood by testing the effects of subchronic treatment with the mammalian target of rapamycin inhibitors and autophagy enhancers rapamycin and temsirolimus in a model for mania and in a model for antidepressant action, respectively...
August 2, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28769564/modeling-association-between-times-to-recurrence-of-the-different-polarities-in-bipolar-disorder-among-service-seekers-in-urban-nigeria-a-survival-analysis-approach
#9
Adeniyi Francis Fagbamigbe, Victor Adesola Makanjuola
INTRODUCTION: Bipolar disorder (BD) remains both a clinical and public health challenge worldwide, especially in developing countries such as Nigeria. Many studies have focused on prevalence and recurrences among BD service seekers but little has been documented on the nature, strength, direction, existence, and estimation of association between times to recurrence of the two possible polarities or mood episodes in BD. In this study, we explored the association between durations before recurrence of depression and manic episodes among people seeking treatment for BD...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28761093/combined-serum-levels-of-multiple-proteins-in-tpa-bdnf-pathway-may-aid-the-diagnosis-of-five-mental-disorders
#10
Suzhen Chen, Haitang Jiang, Yang Liu, Zhenhua Hou, Yingying Yue, Yuqun Zhang, Fuying Zhao, Zhi Xu, Yinghui Li, Xiaodong Mou, Lei Li, Tianyu Wang, Jingjing Zhao, Chongyang Han, Yuxiu Sui, Ming Wang, Zhong Yang, Yan Lu, Yifeng Zhu, Jianhua Li, Xinhua Shen, Fei Sun, Qingsong Chen, Huanxin Chen, Yonggui Yuan
Mental disorders are severe, disabling conditions with unknown etiology and are commonly misdiagnosed when clinical symptomology criteria are solely used. Our previous work indicated that combination of serum levels of multiple proteins in tissue plasminogen activator (tPA)-brain-derived neurotrophic factor (BDNF) pathway improved accuracy of diagnosis of major depressive disorder (MDD). Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28754505/mapping-emotional-disorders-at-the-finest-level-convergent-validity-and-joint-structure-based-on-alternative-measures
#11
Allison Dornbach-Bender, Camilo J Ruggero, Monika A Waszczuk, Wakiza Gamez, David Watson, Roman Kotov
BACKGROUND: Traditional categorization of emotional disorders suffers from within-disorder heterogeneity and excessive comorbidity. Quantitative nosology instead proposes grouping homogenous components of these disorders within a higher order internalizing dimension. However, the precise number, composition, and hierarchical structure of these components remains unclear and varies based on assessment tools. METHODS: The present study jointly examined two assessment systems with the broadest coverage of homogeneous emotional disorder components-the revised Interview for Mood and Anxiety Symptoms (IMAS-R) and the self-report-based expanded version of the Inventory of Depression and Anxiety Symptoms (IDAS-II)-to map their convergent and discriminant validity and joint structure in outpatient (N=426) and treated student (N=306) samples...
June 29, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28753472/longitudinal-mood-monitoring-in-bipolar-disorder-course-of-illness-as-revealed-through-a-short-messaging-service
#12
Rebecca F McKnight, Amy C Bilderbeck, David J Miklowitz, Christopher Hinds, Guy M Goodwin, John R Geddes
BACKGROUND: Online self-monitoring of mood can be used to investigate differences in course patterns across patient groups. This study explored the feasibility of remote symptom capture with True Colours, a self-rated online mood monitoring tool completed on a weekly basis. METHODS: Participants with bipolar disorder (N = 297) completed weekly depression and mania questionnaires over an average of 27.5 months (range 1 -81 months). Subgroups defined by sex, age, and bipolar I vs...
July 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28741646/aggressiveness-in-depression-a-neglected-symptom-possibly-associated-with-bipolarity-and-mixed-features
#13
N Verdolini, G Perugi, L Samalin, A Murru, J Angst, J-M Azorin, C L Bowden, S Mosolov, A H Young, M Barbuti, G Guiso, D Popovic, E Vieta, I Pacchiarotti
OBJECTIVE: To evaluate aggressiveness during a major depressive episode (MDE) and its relationship with bipolar disorder (BD) in a post hoc analysis of the BRIDGE-II-MIX study. METHOD: A total of 2811 individuals were enrolled in this multicenter cross-sectional study. MDE patients with (MDE-A, n = 399) and without aggressiveness (MDE-N, n = 2412) were compared through chi-square test or Student's t-test. A stepwise backward logistic regression model was performed...
July 25, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28731778/a-pharmacologic-algorithm-for-youth-who-are-at-high-risk-for-bipolar-disorder
#14
Christopher D Schneck, Kiki D Chang, Manpreet K Singh, Melissa P DelBello, David J Miklowitz
OBJECTIVE: Depression and brief periods of manic symptoms are linked to a significant risk of progression to bipolar disorder (BD) in children who have a first-degree relative with BD I or II. However, little evidence exists to guide the pharmacologic management of children with these high-risk phenotypes. We propose a pharmacological treatment algorithm for high-risk youth and present results on its use in a study of children with a first-degree relative with BD. METHODS: Subjects were 40 youth (mean 12...
July 21, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28728090/remote-mood-monitoring-for-adults-with-bipolar-disorder-an-explorative-study-of-compliance-and-impact-on-mental-health-service-use-and-costs
#15
J Simon, K Budge, J Price, G M Goodwin, J R Geddes
BACKGROUND: Remote monitoring of mood disorders may be an effective and low resource option for patient follow-up, but relevant evidence remains very limited. This study explores real-life compliance and health services impacts of mood monitoring among patients with bipolar disorder in the UK. METHODS: Patients with a diagnosis of bipolar disorder who were registered users of the True Colours monitoring system for at least 12months at study assessment were included in this retrospective cohort study (n=79)...
July 3, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28725956/non-suicidal-self-injury-in-pediatric-bipolar-disorder-clinical-correlates-and-impact-on-psychosocial-treatment-outcomes
#16
Heather A MacPherson, Sally M Weinstein, Amy E West
Non-suicidal self-injury (NSSI) in childhood is not well documented, especially among youth with pediatric bipolar disorder (PBD). The current study evaluated prevalence and correlates of NSSI, and its impact on intervention response, in a randomized trial of Child- and Family-Focused Cognitive-Behavioral Therapy (CFF-CBT) versus Treatment As Usual (TAU), adjunctive to pharmacotherapy. This study included 72 children ages 7-13 (58% male) with PBD. NSSI and correlates were assessed at baseline; mood and psychiatric severity were measured longitudinally...
July 20, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28722128/solar-insolation-in-springtime-influences-age-of-onset-of-bipolar-i-disorder
#17
M Bauer, T Glenn, M Alda, M A Aleksandrovich, O A Andreassen, E Angelopoulos, R Ardau, Y Ayhan, C Baethge, S R Bharathram, R Bauer, B T Baune, C Becerra-Palars, F Bellivier, R H Belmaker, M Berk, Y Bersudsky, Ş Bicakci, H Birabwa-Oketcho, T D Bjella, L Bossini, J Cabrera, E Y W Cheung, M Del Zompo, S Dodd, M Donix, B Etain, A Fagiolini, K N Fountoulakis, M A Frye, A Gonzalez-Pinto, J F Gottlieb, P Grof, H Harima, C Henry, E T Isometsä, S Janno, F Kapczinski, M Kardell, S Khaldi, S Kliwicki, B König, T L Kot, R Krogh, M Kunz, B Lafer, M Landén, E R Larsen, U Lewitzka, R W Licht, C Lopez-Jaramillo, G MacQueen, M Manchia, W Marsh, M Martinez-Cengotitabengoa, I Melle, F Meza-Urzúa, M Yee Ming, S Monteith, G Morken, E Mosca, R Munoz, S V Mythri, F Nacef, R K Nadella, F G Nery, R E Nielsen, C O'Donovan, A Omrani, Y Osher, H Østermark Sørensen, U Ouali, Y Pica Ruiz, M Pilhatsch, M Pinna, F D R da Ponte, D Quiroz, R Ramesar, N Rasgon, M S Reddy, A Reif, P Ritter, J K Rybakowski, K Sagduyu, Â M Scippa, E Severus, C Simhandl, D J Stein, S Strejilevich, M Subramaniam, A H Sulaiman, K Suominen, H Tagata, Y Tatebayashi, L Tondo, C Torrent, A E Vaaler, J Veeh, E Vieta, B Viswanath, M Yoldi-Negrete, M Zetin, Y Zgueb, P C Whybrow
OBJECTIVE: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. METHOD: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. RESULTS: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset...
July 19, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28711816/unilateral-subthalamotomy-in-parkinson-s-disease-cognitive-psychiatric-and-neuroimaging-changes
#18
Ignacio Obeso, Enrique Casabona, Rafael Rodríguez-Rojas, Maria Luisa Bringas, Raúl Macías, Nancy Pavón, Jose A Obeso, Marjan Jahanshahi
Unilateral subthalamotomy is an effective treatment for the cardinal motor features of Parkinson's disease (PD). However, non-motor changes possibly associated with right or left subthalamotomy remain unknown. Our aim was to assess cognitive, psychiatric and neuroimaging changes after treatment with unilateral subthalamotomy. Fourteen medicated patients with PD were evaluated before and after (mean 6 months after operation) unilateral subthalamotomy (5 right, 9 left). In addition to motor assessments, cognitive (global cognition and executive functions), psychiatric (apathy, depression, anxiety, mania, hypo- and hyperdopaminergic behaviours, impulsivity), quality of life evaluations and volume of lesions were obtained...
June 27, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28709880/low-intensity-transcranial-electric-stimulation-safety-ethical-legal-regulatory-and-application-guidelines
#19
REVIEW
A Antal, I Alekseichuk, M Bikson, J Brockmöller, A R Brunoni, R Chen, L G Cohen, G Dowthwaite, J Ellrich, A Flöel, F Fregni, M S George, R Hamilton, J Haueisen, C S Herrmann, F C Hummel, J P Lefaucheur, D Liebetanz, C K Loo, C D McCaig, C Miniussi, P C Miranda, V Moliadze, M A Nitsche, R Nowak, F Padberg, A Pascual-Leone, W Poppendieck, A Priori, S Rossi, P M Rossini, J Rothwell, M A Rueger, G Ruffini, K Schellhorn, H R Siebner, Y Ugawa, A Wexler, U Ziemann, M Hallett, W Paulus
Low intensity transcranial electrical stimulation (TES) in humans, encompassing transcranial direct current (tDCS), transcutaneous spinal Direct Current Stimulation (tsDCS), transcranial alternating current (tACS), and transcranial random noise (tRNS) stimulation or their combinations, appears to be safe. No serious adverse events (SAEs) have been reported so far in over 18,000 sessions administered to healthy subjects, neurological and psychiatric patients, as summarized here. Moderate adverse events (AEs), as defined by the necessity to intervene, are rare, and include skin burns with tDCS due to suboptimal electrode-skin contact...
June 19, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28706563/quality-of-life-in-children-and-adolescents-with-bipolar-i-depression-treated-with-olanzapine-fluoxetine-combination
#20
Daniel J Walker, Melissa P DelBello, John Landry, Deborah N D'Souza, Holland C Detke
BACKGROUND: We examined the efficacy of olanzapine/fluoxetine combination (OFC) in improving health-related quality of life (QoL) in the treatment of bipolar depression in children and adolescents. METHODS: Patients aged 10-17 years with bipolar I disorder, depressed episode, baseline children's depression rating scale-revised (CDRS-R) total score ≥40, Young Mania Rating Scale (YMRS) total score ≤15, and YMRS-item 1 ≤ 2 were randomized to OFC (6/25-12/50 mg/day olanzapine/fluoxetine; n = 170) or placebo (n = 85) for up to 8 weeks of double-blind treatment...
2017: Child and Adolescent Psychiatry and Mental Health
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