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vasoactive amins

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https://www.readbyqxmd.com/read/28484527/effect-of-radiation-on-brain-tissue-endothelin-1-level-and-tumor-development
#1
Metin Kaplan, Ahmet Kılınç, Sait Ozturk, Nevin Ilhan, Simay Gurocak, Murat Gonen
BACKGROUND: Radiotherapy causes injury in the endothelial cells of blood vessels and the production of vasoactive amines such as endothelin-1 (ET-1). ET-1 is an important peptide in cancer development. In this study, the effects of radiation on brain tissue ET-1 level were evaluated. Is it possible to suggest a mechanism using ET-1 level in the production of this adverse effect? In this paper, the relationship between the development of brain tumors and the ET-1 level has been discussed...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28427403/preoperative-carbohydrate-load-and-intraoperatively-infused-omega-3-polyunsaturated-fatty-acids-positively-impact-nosocomial-morbidity-after-coronary-artery-bypass-grafting-a-double-blind-controlled-randomized-trial
#2
Gibran Roder Feguri, Paulo Ruiz Lúcio de Lima, Danilo de Cerqueira Borges, Laura Ramos Toledo, Larissa Nadaf Batista, Thaís Carvalho E Silva, Neuber José Segri, José Eduardo de Aguilar-Nascimento
BACKGROUND: A strategy of limited preoperative fasting, with carbohydrate (CHO) loading and intraoperative infusion of omega-3 polyunsaturated fatty acids (ω-3 PUFA), has seldom been tried in cardiovascular surgery. Brief fasting, followed by CHO intake 2 h before anesthesia, may improve recovery from CABG procedures and lower perioperative vasoactive drug requirements. Infusion of ω-3 PUFA may reduce occurrences of postoperative atrial fibrillation (POAF) and shorten hospital stays...
April 20, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28348058/edema-and-nociception-induced-by-philodryas-patagoniensis-venom-in-mice-a-pharmacological-evaluation-with-implications-for-the-accident-treatment
#3
Priscila Hess Lopes, Marisa M T Rocha, Alexandre Kazuo Kuniyoshi, Fernanda Calheta Vieira Portaro, Luís Roberto C Gonçalves
We have investigated the mechanisms involved in the genesis of edema and nociception induced by Philodryas patagoniensis venom (PpV) injected into the footpad of mice. PpV induced dose-related edema and nociceptive effects. Pretreatment of mice with cyclooxygenase inhibitor (indomethacin), but not with cyclooxygenase 2 inhibitor (celecoxib) markedly inhibited both effects. Pretreatments with H1 receptor antagonist (promethazine) or with dual histamine-serotonin inhibitor (cyproheptadine) failed in inhibiting both effects...
June 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28228728/perivascular-adipose-tissue-s-impact-on-norepinephrine-induced-contraction-of-mesenteric-resistance-arteries
#4
Nadia Ayala-Lopez, Janice M Thompson, Stephanie W Watts
Background: Perivascular adipose tissue (PVAT) can decrease vascular contraction to NE. We tested the hypothesis that metabolism and/or uptake of vasoactive amines by mesenteric PVAT (MPVAT) could affect NE-induced contraction of the mesenteric resistance arteries. Methods: Mesenteric resistance vessels (MRV) and MPVAT from male Sprague-Dawley rats were used. RT-PCR and Western blots were performed to detect amine metabolizing enzymes. The Amplex® Red Assay was used to quantify oxidase activity by detecting the oxidase reaction product H2O2 and the contribution of PVAT on the mesenteric arteries' contraction to NE was measured by myography...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28008798/risk-assessment-of-dietary-exposure-to-tryptamine-for-the-austrian-population
#5
Nadja Wüst, Elke Rauscher-Gabernig, Johann Steinwider, Friedrich Bauer, Peter Paulsen
Tryptamine acts as a neuromodulator and vasoactive agent in the human body. Dose-response data on dietary tryptamine are scarce and neither a toxicological threshold value nor tolerable levels in foods have been established so far. This paper reviews dose-response characteristics and toxicological effects of tryptamine as well as tryptamine contents in food, estimates dietary exposure of Austrian consumers, and calculates risk-based maximum tolerable limits for food categories. A dose without effect of 8 mg kg(-1) body weight day(-1) was derived from literature data...
March 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27719888/impact-of-salt-reduction-on-biogenic-amines-fatty-acids-microbiota-texture-and-sensory-profile-in-traditional-blood-dry-cured-sausages
#6
Marta Laranjo, Ana Gomes, Ana Cristina Agulheiro-Santos, Maria Eduarda Potes, Maria João Cabrita, Raquel Garcia, João Miguel Rocha, Luísa Cristina Roseiro, Maria José Fernandes, Maria João Fraqueza, Miguel Elias
Meat industry needs to reduce salt in their products due to health issues. The present study evaluated the effect of salt reduction from 6% to 3% in two Portuguese traditional blood dry-cured sausages. Physicochemical and microbiological parameters, biogenic amines, fatty acids and texture profiles and sensory panel evaluations were considered. Differences due to salt reduction were perceptible in a faint decline of water activity, which slightly favoured microbial growth. Total biogenic amines content ranged from 88...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27561907/use-of-methylene-blue-to-treat-hypovolemic-shock-followed-by-ischemia-reperfusion-injury-in-the-postoperative-orthotopic-liver-transplant-patient-a-case-report
#7
Kelvin Henrique Vilalva, Fabrícia Teixeira Mumic, Marina Rodrigues Garcia Silveira, Enio David Mente, Paulo Roberto Barbosa Evora, Orlando Castro E Silva
A 57-year-old female patient received elective liver transplant due to nonalcoholic steatohepatitis complicated by hepatocellular carcinoma. Her preoperative Model for End-Stage Liver Disease score was 11. The total transplant ischemic time was 10 hours and 35 minutes, and the warm ischemic time was 35 minutes. Even with aggressive fluid overload and use of high concentrations of vasoactive amines, the patient developed possible primary graft dysfunction with poor response to fluids and vasopressor support, suggesting vasoplegic syndrome...
August 24, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27437904/vasorelaxant-effects-of-2-nitro-1-phenyl-1-propanol-in-rat-aorta
#8
Teresinha Silva de Brito, Francisco José Batista de Lima, Kalinne Kelly Lima Gadelha, Patrícia Andrea da Fonseca Magalhães, Saad Lahlou, Pedro Jorge Caldas Magalhães
2-Nitro-1-phenyl-1-propanol (NPP) is a nitro alcohol that is known as an intermediate in the synthesis of sympathomimetic agents, such as norephedrine. The present study investigated the vasoactive effects of NPP on rat aorta. In endothelium-intact aortic rings, NPP fully relaxed contractions that were induced by phenylephrine, KCl, and U-46619. The relaxant effects of NPP on phenylephrine-elicited contractions remained unaffected by NG-nitro-L-arginine methyl ester (L-NAME), indomethacin, propranolol, tetraethylammonium, 4-aminopyridine, and glibenclamide...
July 20, 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/26994298/part-ii-biochemical-changes-after-pituitary-adenylate-cyclase-activating-polypeptide-38-infusion-in-migraine-patients
#9
Song Guo, Anne Luise Haulund Vollesen, Young Bae Lee Hansen, Erik Frandsen, Malene Rohr Andersen, Faisal Mohammad Amin, Jan Fahrenkrug, Jes Olesen, Messoud Ashina
Background Intravenous infusion of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) provokes migraine attacks in 65-70% of migraine without aura (MO) patients. We investigated whether PACAP38 infusion causes changes in the endogenous production of PACAP38, vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP), tumour necrosis factor alpha (TNFα), S100 calcium binding protein B (S100B), neuron-specific enolase and pituitary hormones in migraine patients. Methods We allocated 32 previously genotyped MO patients to receive intravenous infusion PACAP38 (10 pmol/kg/minute) for 20 minutes and recorded migraine-like attacks...
February 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/26930260/daily-expression-of-genes-coding-for-neurotransmitters-in-central-and-peripheral-tissues-of-redheaded-bunting-implication-for-circadian-regulation-of-physiology-in-songbirds
#10
Ila Mishra, Devraj Singh, Vinod Kumar
In birds, circadian control of tissue level communication is not well understood. The present study investigated this, by monitoring daily oscillation of genes coding for peptides (neuropeptide Y, NPY; vasoactive intestinal peptide, VIP; somatostatis, SST) and intermediary enzymes of amine and amino acid neurotransmitters (dopamine [tyrosine hydroxylase, TH]; glutamate [glutaminase, GLS; glutamate oxaloacetate transaminase 2, GOT2]; gamma amino butyric actid, GABA [glutamic acid decarboxylase 65, GAD65]) biosynthetic pathway, along with c-FOS as an activation marker, in different tissues of migratory redheaded buntings, Emberiza bruniceps...
2016: Chronobiology International
https://www.readbyqxmd.com/read/26910507/preeclampsia-and-future-cardiovascular-risk-a-point-of-view-from-the-clearance-of-plasma-vasoactive-amines
#11
REVIEW
Shi-Sheng Zhou, Yi-Ming Zhou, Da Li, Na-Na Chen
OBJECTIVE: To summarize the reported evidence on the relationship between vasoactive amines and preeclampsia. METHODS: A literature search was conducted in MEDLINE/PubMed and EMBASE. RESULTS: The summarized results are as follows: (1) Menstruation can effectively eliminate vasoactive amines norepinephrine, serotonin and histamine. (2) Pregnancy increases norepinephrine production due to fetal brain development and decreases vasoactive-amine elimination due to amenorrhea...
2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/26674334/change-in-brain-network-connectivity-during-pacap38-induced-migraine-attacks-a-resting-state-functional-mri-study
#12
RANDOMIZED CONTROLLED TRIAL
Faisal Mohammad Amin, Anders Hougaard, Stefano Magon, Mohammad Sohail Asghar, Nur Nabil Ahmad, Egill Rostrup, Till Sprenger, Messoud Ashina
OBJECTIVE: To investigate resting-state functional connectivity in the salience network (SN), the sensorimotor network (SMN), and the default mode network (DMN) during migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38 (PACAP38). METHODS: In a double-blind, randomized study, 24 female migraine patients without aura received IV PACAP38 or vasoactive intestinal polypeptide (VIP) over 20 minutes. Both peptides are closely related and cause vasodilation, but only PACAP38 induces migraine attacks...
January 12, 2016: Neurology
https://www.readbyqxmd.com/read/26506493/-anaphylactic-shock-associated-with-ceftriaxone-case-report-and-literature-review
#13
REVIEW
Luis Del Carpio-Orantes, Hugo Alberto Azuara-Trujillo
This study presents a case of anaphylactic shock in a senile patient, who had a biphasic event associated with the administration of a beta-lactam cephalosporin (ceftriaxone), needing stay in the intensive care unit and support with vasoactive amines, which it is rare to see in this issue, already being in itself a difficult diagnosis and often undervalued by rejecting causes of shock in a senile patient other than cardiogenic or septic. Also, a case review is made based on epidemiological issues, clinical and paraclinical diagnosis, and current treatment implications based on current international guidelines and a review of the topic...
November 2015: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/26303702/biochemical-testing-in-patients-with-neuroendocrine-tumors
#14
REVIEW
Dan Granberg
Neuroendocrine tumors are usually slow-growing tumors. Many of these are capable of secreting peptide hormones or biogenic amines that may lead to endocrine syndromes. Nonfunctioning tumors can either secrete no hormones at all, or secrete hormones not giving rise to endocrine symptoms, such as chromogranin A, chromogranin B or pancreatic polypeptide. Chromogranin A is produced by the majority of endocrine tumors, both functioning and nonfunctioning, and is the best available marker for diagnosis, follow-up and treatment monitoring of patients with differentiated neuroendocrine tumors...
2015: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/26241122/a-transcriptome-led-exploration-of-molecular-mechanisms-regulating-somatostatin-producing-d-cells-in-the-gastric-epithelium
#15
Alice Adriaenssens, Brian Yee Hong Lam, Lawrence Billing, Katie Skeffington, Sabine Sewing, Frank Reimann, Fiona Gribble
The stomach epithelium contains a myriad of enteroendocrine cells that modulate a range of physiological functions, including postprandial secretion of regulatory peptides, gastric motility, and nutrient absorption. Somatostatin (SST)-producing D-cells are present in the oxyntic and pyloric regions of the stomach, and provide a tonic inhibitory tone that regulates activity of neighboring enteroendocrine cells and gastric acid secretion. Cellular mechanisms underlying the effects of regulatory factors on gastric D-cells are poorly defined due to problems in identifying primary D-cells, and uncertainty remains about which stimuli influence D-cells directly...
November 2015: Endocrinology
https://www.readbyqxmd.com/read/26051949/platelets-in-the-immune-response-revisiting-platelet-activating-factor-in-anaphylaxis
#16
Parwinder Gill, Nina Lakhani Jindal, Amanda Jagdis, Peter Vadas
Anaphylaxis is an acute, severe, life-threatening multisystem allergic reaction resulting from the sudden systemic release of biochemical mediators and chemotactic substances. Release of both preformed granule-associated mediators and newly generated lipid-derived mediators contributes to the amplification and prolongation of anaphylaxis. Platelet-activating factor (PAF) is a potent phospholipid-derived mediator the central role of which has been well established in experimental models of both immune-mediated and non-immune mediated anaphylaxis...
June 2015: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/25452775/expression-of-serotonin-receptors-in-human-lower-esophageal-sphincter
#17
He-Fei Li, Jun-Feng Liu, Ke Zhang, Yong Feng
Serotonin (5-HT) is a neurotransmitter and vasoactive amine that is involved in the regulation of a large number of physiological functions. The wide variety of 5-HT-mediated functions is due to the existence of different classes of serotonergic receptors in the mammalian gastrointestinal tract and nervous system. The aim of this study was to explore the expression of multiple types of 5-HT receptor (5-HT1AR, 5-HT2AR, 5-HT3AR, 5-HT4R, 5-HT5AR, 5-HT6R and 5-HT7R) in sling and clasp fibers from the human lower esophageal sphincter (LES)...
January 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/25388249/the-parasympathetic-nervous-system-as-a-regulator-of-mast-cell-function
#18
REVIEW
Paul Forsythe
Often considered as the archetype of neuroimmune communication, much of our understanding of the bidirectional relationship between the nervous and immune systems has come from the study of mast cell-nerve interaction. Mast cells play a role in resistance to infection and are extensively involved in inflammation and subsequent tissue repair. Thus, the relationship between mast cells and neurons enables the involvement of peripheral and central nervous systems in the regulation of host defense mechanisms and inflammation...
2015: Methods in Molecular Biology
https://www.readbyqxmd.com/read/24960780/alithiasic-cholecystitis-treated-by-percutaneous-cholecystostomy-in-a-patient-with-severe-septic-shock-and-neutropenia
#19
N Simion
Acalculous cholecystitis is a relatively rare form of cholecystitis appearing in severely ill patients. We chose the case of a young patient under chemotherapy for myeloid leukaemia who developed a severe septic shock secondary to an alithiasic cholecystitis. Because of hemodynamic instability needing high-dose of vasoactive amines, percutaneous gallbladder drainage was done. After this intervention, the septic shock could be controlled, but a bleeding liver laceration was observed, fortunately without morbidity consequences...
2012: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/24851400/the-circadian-organization-of-the-cardiovascular-system-in-health-and-disease
#20
REVIEW
Francesco Portaluppi
In normal conditions, the temporal organization of blood pressure (BP) is mainly controlled by neuroendocrine mechanisms. Above all, the monoaminergic systems (including variations in activity of the autonomous nervous system, and in secretion of biogenic amines) appear to integrate the major driving factors of temporal variability, but evidence is available also for a role of the hypothalamic-pituitary-adrenal, hypothalamic-pituitary-thyroid, opioid, renin-angiotensin-aldosterone, and endothelial systems, as well as other vasoactive peptides...
May 2014: Indian Journal of Experimental Biology
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