Katarzyna Grycel, Nick Y Larsen, Yinghang Feng, Klaus Qvortrup, Poul Henning Jensen, Mishal Fayyaz, Malene G Madsen, Jens Midtgaard, Zhiheng Xu, Stine Hasselholt, Jens R Nyengaard
Collapsin response mediator protein 2 (CRMP2) is a member of a protein family, which is highly involved in neurodevelopment, but most of its members become heavily downregulated in adulthood. CRMP2 is an important factor in neuronal polarization, axonal formation and growth cone collapse. The protein remains expressed in adulthood, but is more region specific. CRMP2 is present in adult corpus callosum (CC) and in plastic areas like prefrontal cortex and hippocampus. CRMP2 has been implicated as one of the risk-genes for Schizophrenia (SZ)...
July 19, 2023: Molecular and Cellular Neurosciences