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JOURNAL ARTICLE
Emmanuelle Uro-Coste
No abstract text is available yet for this article.
March 29, 2024: Annales de Pathologie
#22
JOURNAL ARTICLE
Boštjan Jakše, Uroš Godnov, Zlatko Fras, Nataša Fidler Mis
A plant-based diet rich in whole foods and fiber is beneficial for cardiovascular (CV) health. This impact is often linked to specific food groups and their preparation methods, reflecting the overall dietary pattern. However, research on the long-term effects of a carefully designed plant-based diet on adults transitioning from a typical Western lifestyle is limited. Notably, studies on people managing CV risk factors effectively are scarce. As part of a cross-sectional study, we examined 151 individuals committed to a long-term, well-designed plant-based diet and active lifestyle...
March 11, 2024: Nutrients
#23
REVIEW
Tisa Hodnik, Stiven Roytman, Nico I Bohnen, Uros Marusic
Phase-amplitude coupling (PAC) describes the interaction of two separate frequencies in which the lower frequency phase acts as a carrier frequency of the higher frequency amplitude. It is a means of carrying integrated streams of information between micro- and macroscale systems in the brain, allowing for coordinated activity of separate brain regions. A beta-gamma PAC increase over the sensorimotor cortex has been observed consistently in people with Parkinson's disease (PD). Its cause is attributed to neural entrainment in the basal ganglia, caused by pathological degeneration characteristic of PD...
March 15, 2024: Life
#24
JOURNAL ARTICLE
Nobuki Furubayashi, Akinori Minato, Toshihisa Tomoda, Yoshifumi Hori, Keijiro Kiyoshima, Takahito Negishi, Yusuke Haraguchi, Toshiki Koga, Kenichi Harada, Kentaro Kuroiwa, Naohiro Fujimoto, Motonobu Nakamura
BACKGROUND/AIM: The association between clinical outcomes and posttreatment changes in the neutrophil-to-lymphocyte ratio (NLR) and neutrophil-to-eosinophil ratio (NER) in patients receiving avelumab maintenance therapy for advanced urothelial carcinoma (UC) is unclear. PATIENTS AND METHODS: We retrospectively analyzed data from advanced UC patients who received avelumab and had not progressed with first-line platinum-based chemotherapy. The association between the changes in NLR and NER from pretreatment to week 6 of avelumab treatment and therapeutic efficacy was evaluated...
April 2024: Anticancer Research
#25
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 2024: Aktuelle Urologie
#26
JOURNAL ARTICLE
Tatjana Maravić, Claudia Mazzitelli, Allegra Comba, Uros Josic, Federico Del Bianc, Annamaria Forte, Darko Vasiljević, Larisa Blažić, Lorenzo Breschi, Annalisa Mazzoni
PURPOSE: The aim of the present study was to investigate the influence of three post-and-core systems and two crown materials on stresses in restored premolars using Finite Element Analysis (FEA). MATERIALS AND METHODS: A maxillary second premolar 3D model was created in SolidWorks 2014 (Dassault Systémés). Severe loss of tooth structure was simulated with six restorative options: 1) glass-fiber-reinforced composite post and composite core (GFRC)+CAD/CAM leucite-reinforced glass-ceramic crown (LRC); 2) carbon-fiberreinforced composite post and composite core (CFRC)+LRC; 3) metal cast post-and-core (MPC)+LRC 4) GFRC+CAD/CAM composite resin crown (CC); 5) CFRC+CC; 6) MPC+CC...
March 22, 2024: International Journal of Prosthodontics
#27
EDITORIAL
Gabrijela Horvat, Uroš Maver
Aerogels are unique solid materials that consist mainly of air and have an extremely low density, large open pores, and a large internal surface area [...].
February 20, 2024: Gels
#28
JOURNAL ARTICLE
Elena Tatarova, Ana Dias, Plamen Dankov, Jivko Kissovski, Ana Maria Botelho do Rego, Neli Bundaleska, Edgar Felizardo, Miroslav Abrashev, Ana Maria Ferraria, Thomas Strunskus, Vasyl Shvalya, Neelakandan M Santhosh, Ivan Valeriev Ivanov, Martin Košiček, Janez Zavašnik, Luis Lemos Alves, Bruno Gonçalves, Uroš Cvelbar
Materials with tunable negative electromagnetic performance, i.e., where dielectric permittivity becomes negative, have long been pursued in materials research due to their peculiar electromagnetic (EM) characteristics. Here, this promising feature is reported in materials on the case of plasma-synthesized nitrogen-doped graphene sheets with tunable permittivity over a wide (1-40 GHz) frequency range. Selectively incorporated nitrogen atoms in a graphene scaffold tailor the electronic structure in a way that provides an ultra-low energy (0...
March 27, 2024: Small
#29
JOURNAL ARTICLE
Anđelka Račić, Bisera Jurišić Dukovski, Jasmina Lovrić, Vladimir Dobričić, Sonja Vučen, Ana Micov, Radica Stepanović-Petrović, Maja Tomić, Uroš Pecikoza, Jelena Bajac, Danina Krajišnik
The incorporation of polymers into drug delivery vehicles has been shown to be a useful approach to prolong the residence time of drugs in the precorneal tear film and to improve penetration into biological membranes. The main objective of this research was to formulate novel viscous eye drops with ketotifen as the active ingredient, containing the polysaccharides: chitosan (MCH), hydroxypropyl guar gum (HPG) and hyaluronic acid (SH) alone and in combination as functional polymers. DSC and FT-IR techniques showed the compatibility between ketotifen and polymers...
March 22, 2024: International Journal of Pharmaceutics
#30
JOURNAL ARTICLE
Przemysław R Kac, Fernando González-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay R Varma, Nicholas J Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C Troncoso, Tammaryn Lashley, Gunnar Brinkmalm, Susan M Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas K Karikari
Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer's disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize tau forms phosphorylated additionally at threonine-212, but the contribution of p-tau212 alone to AD is unknown. We developed a blood-based immunoassay that is specific to p-tau212 without cross-reactivity to p-tau217. Here, we examined the diagnostic utility of plasma p-tau212. In five cohorts (n = 388 participants), plasma p-tau212 showed high performances for AD diagnosis and for the detection of both amyloid and tau pathology, including at autopsy as well as in memory clinic populations...
March 23, 2024: Nature Communications
#31
JOURNAL ARTICLE
Xiaoyu Yang, Shuomin Wang, Chen Sun, Yunhong Xia
PURPOSE: According to some cohort studies, an association exists between acute intermittent porphyria (AIP) and liver cancer. However, establishing a definitive causal relationship between porphyria and hepatocellular carcinoma (HCC) remains challenging. Prexisting studies regarding porphyria biomarkers and alcohol-related hepatocellular carcinoma (AR-HCC) make possible an entry point. In this study, we aimed to investigate the causal relationships between biomarkers of two types of porphyria, AIP and congenital erythropoietic porphyria (CEP), and AR-HCC...
2024: PloS One
#32
JOURNAL ARTICLE
Constantin Rieger, Jörg Schlüchtermann, Enno Storz, Lucas Kastner, David Pfister, Axel Heidenreich
OBJECTIVE: Radical cystectomy (RC) is the standard of care (SOC) in BCG-unresponsive NMIBC and is associated with a significant health-related quality-of-life burden. Recently, promising results have been published on Gemcitabine/Docetaxel, Pembrolizumab, and Hyperthermic Intravesical Chemotherapy (HIVEC) as salvage therapy options trying to increase the rate of bladder preservation. Here, we performed a Cost-Effectiveness-Analysis of those treatment modalities. PATIENTS AND METHODS: We developed a Markov model from a payer's perspective drawing on clinical data of single-arm trials testing intravesical gemcitabine/docetaxel and pembrolizumab in BCG-unresponsive NMIBC, as well as clinical data from patients receiving hyperthermic intravesical chemotherapy HIVEC (n = 29) as intravesical salvage chemotherapy at our uro-oncological centre in Cologne...
March 16, 2024: BJU International
#33
JOURNAL ARTICLE
Avril Lusty, Janet Alexanian, Simon Kitto, Tim Wood, Luke T Lavallée, Chris Morash, Ilias Cagiannos, Rodney H Breau, Isabelle Raîche
OBJECTIVE: To illustrate how experts efficiently navigate a "slowing down moment" to obtain optimal surgical outcomes using the neurovascular bundle sparing during a robotic prostatectomy as a case study. DESIGN: A series of semistructured interviews with four expert uro-oncologists were completed using a cognitive task analysis methodology. Cognitive task analysis, CTA, refers to the interview and extraction of a general body of knowledge. Each interview participant completed four 1 to 2-hour semistructured CTA interviews...
April 2024: Journal of Surgical Education
#34
JOURNAL ARTICLE
Anthony Atala
No abstract text is available yet for this article.
March 15, 2024: Journal of Urology
#35
JOURNAL ARTICLE
Predrag Zdujic, Aleksandar Bogdanovic, Uros Djindjic, Jelena Djokic Kovac, Dragan Basaric, Nenad Zdujic, Vladimir Dugalic
BACKGROUND: The aim of this study was to compare postoperative outcomes following liver resection between patients with prolonged cumulative ischemia time (CIT) which exceeded 60 min and patients with CIT less than 60 min. METHODS: Between March 2020 and October 2022, 164 consecutive patients underwent liver resection at the Unit for hepato-bilio-pancreatic surgery, University Clinic for Digestive Surgery in Belgrade, Serbia. Intermittent Pringle maneuver was routinely applied...
March 13, 2024: Asian Journal of Surgery
#36
COMPARATIVE STUDY
Hiranya Deka, Ginil Kumar Pooleri, Badiginchala Suguna, Ramiah Rajeshkannan, Resmi Sekhar, M R Bindhu, Vishnu Prasad
PURPOSE: To compare diagnostic accuracy in localization and detection of extraprostatic extension (EPE), seminal vesicle invasion (SVI), lymph node involvement (LNI) between PSMA PET MRI and multiparametric MRI (mpMRI) in carcinoma prostate. METHODS: We did a prospective study of consecutive men with biopsy-proven prostate cancer who underwent radical prostatectomy between July'2020 and Dec'2021 at our institution. Patients underwent PSMA PET MRI imaging. MpMRI findings were inferred separately by another radiologist who was blinded to the PSMA PET findings...
March 14, 2024: World Journal of Urology
#37
JOURNAL ARTICLE
Pooja M Shah, Uros Rakita Md, Caroline Porter, Steven R Feldman
No abstract text is available yet for this article.
October 15, 2023: Dermatology Online Journal
#38
RANDOMIZED CONTROLLED TRIAL
Evdoxia Kyriazopoulou, Yehudit Hasin-Brumshtein, Uros Midic, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Myrto Astriti, Archontoula Fragkou, Aggeliki Rapti, Eleonora Taddei, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vasiliki Tzavara, Sofia Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Vasileios Kotsis, Dionysios G Tsoukalas, Carlo Selmi, Alexandra Konstantinou, Michael Samarkos, Michael Doumas, Aikaterini Masgala, Konstantinos Pagkratis, Aikaterini Argyraki, Karolina Akinosoglou, Styliani Symbardi, Mihai G Netea, Periklis Panagopoulos, George N Dalekos, Oliver Liesenfeld, Timothy E Sweeney, Purvesh Khatri, Evangelos J Giamarellos-Bourboulis
BACKGROUND: Endotype classification may guide immunomodulatory management of patients with bacterial and viral sepsis. We aimed to identify immune endotypes and transitions associated with response to anakinra (human interleukin 1 receptor antagonist) in participants in the SAVE-MORE trial. METHODS: Adult patients hospitalized with radiological findings of PCR-confirmed severe pneumonia caused by SARS-CoV-2 and plasma-soluble urokinase plasminogen activator receptor levels of ≥ 6 ng/ml in the SAVE-MORE trial (NCT04680949) were characterized at baseline and days 4 and 7 of treatment using a previously defined 33-messenger RNA classifier to assign an immunological endotype in blood...
March 12, 2024: Critical Care: the Official Journal of the Critical Care Forum
#39
REVIEW
Haidar Al Saffar, David C Chen, Carlos Delgado, Jacob Ingvar, Michael S Hofman, Nathan Lawrentschuk, Marlon Perera, Declan G Murphy, Renu Eapen
The review examines the vital role of prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) in the diagnosis, staging, and treatment of prostate cancer (PCa). It focuses on the superior diagnostic abilities of PSMA PET/CT for identifying both nodal and distant PCa, and its potential as a prognostic indicator for biochemical recurrence and overall survival. Additionally, we focused on the variability of PSMA's expression and its impact on personalised treatment, particularly the use of [177 Lu] Lu-PSMA-617 radioligand therapy...
February 26, 2024: Cancers
#40
JOURNAL ARTICLE
Marko Ristanic, Minja Zorc, Uros Glavinic, Jevrosima Stevanovic, Jovan Blagojevic, Milan Maletic, Zoran Stanimirovic
To improve the genomic evaluation of milk-related traits in Holstein-Friesian (HF) cattle it is essential to identify the associated candidate genes. Novel SNP-based analyses, such as the genetic mapping of inherited diseases, GWAS, and genomic selection, have led to a new era of research. The aim of this study was to analyze the association of each individual SNP in Serbian HF cattle with milk production traits and inbreeding levels. The SNP 60 K chip Axiom Bovine BovMDv3 was deployed for the genotyping of 334 HF cows...
February 21, 2024: Animals: An Open Access Journal From MDPI
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