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https://www.readbyqxmd.com/read/29238970/the-consequences-of-sexual-selection-in-well-adapted-and-maladapted-populations-of-bean-beetles
#1
Ivain Martinossi-Allibert, Uroš Savković, Mirko Đorđević, Göran Arnqvist, Biljana Stojković, David Berger
Whether sexual selection generally promotes or impedes population persistence remains an open question. Intralocus sexual conflict (IaSC) can render sexual selection in males detrimental to the population by increasing the frequency of alleles with positive effects on male reproductive success but negative effects on female fecundity. Recent modelling based on fitness landscape theory, however, indicates that the relative impact of IaSC may be reduced in maladapted populations and that sexual selection therefore might promote adaptation when it is most needed...
December 14, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29232351/randomized-clinical-trial-of-lidocaine-analgesia-for-transurethral-bladder-catheterization-delivered-via-blunt-tipped-applicator-in-young-children
#2
Neil G Uspal, Bonnie Strelitz, Jesse Gritton, Kristin Follmer, Miranda C Bradford, Taryn L Colton, Paul A Merguerian, Eileen J Klein
OBJECTIVE: Transurethral bladder catheterization (TUBC) is a painful, frequently performed procedure for collecting sterile urine. We sought to determine if administration of intraurethral lidocaine before TUBC using a blunt tipped syringe decreases procedural pain in young children in the pediatric emergency department. METHODS: Randomized clinical trial of children 0 to 36 months old requiring TUBC for collection of urine in a pediatric emergency department was performed...
December 11, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29225059/effect-of-music-on-outpatient-urological-procedures-a-systematic-review-and-meta-analysis-from-european-section-of-uro-technology-esut
#3
Rena Kyriakides, Patrick Jones, Robert Geraghty, Andreas Skolarikos, Evangellos Liatsikos, Olivier Traxer, Amelia Pietropaolo, Bhaskar K Somani
PURPOSE: Music is a practical, cheap and harmless analgesic and anxiolytic. An increasing number of original studies have been performed investigating its potential application in urology. Our aim was to identify the effect of music on outpatient based urological procedures. METHOD: A systematic review was performed on the effect of using music during all reported outpatient urology procedures including transrectal ultrasound guided prostate biopsy (TRUS), shock-wave lithotripsy (SWL), urodynamic studies (UDS), percutaneous nephrostomy (PCN) tube placement and cystoscopy...
December 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29217368/hla-g-a-haplotypes-in-amerindians-ecuador-hla-g%C3%A2-01-05n-world-distribution
#4
Antonio Arnaiz-Villena, Jose Palacio-Gruber, Mercedes Enriquez de Salamanca, Ignacio Juárez, Cristina Campos, Jorge Nuñez, Ester Muñiz, Jose Manuel Martin-Villa
HLA-G and HLA-A frequencies have been analysed in Amerindians from Ecuador. HLA-G allele frequencies are found to be closer to those of other Amerindians (Mayas from Guatemala and Uros from Peru) and closer to European ones than to Far East Asians groups, particularly, regarding to HLA-G∗ 01:04 allele. HLA-G/-A haplotypes have been calculated for the first time in Amerindians. It is remarkable that HLA-G∗01:05N "null" allele is found in a very low frequency (like in Amerindian Mayas and Uros) and is also found in haplotypes belonging to the HLA-A19 group of alleles (HLA-A∗30, -A∗31,-A∗33)...
December 4, 2017: Human Immunology
https://www.readbyqxmd.com/read/29211320/consensus-statements-on-the-management-of-metastatic-prostate-cancer-from-the-hong-kong-urological-association-and-hong-kong-society-of-uro-oncology
#5
REVIEW
Darren Ming-Chun Poon, Chi-Kwok Chan, Tim-Wai Chan, Foon-Yiu Cheung, Philip Wai-Kay Kwong, Eric Ka-Chai Lee, Angus Kwong-Chuen Leung, Simon Yiu-Lam Leung, Wai-Kit Ma, Hing-Shing So, Po-Chor Tam, Lap-Yin Ho
OBJECTIVES: To establish a set of consensus statements to facilitate physician management strategies for patients with metastatic prostate cancer (mPC) in Hong Kong. MATERIALS AND METHODS: A local expert consensus was organised jointly by the two main professional organisations representing prostate cancer specialists in Hong Kong. A total of 12 experts were included in the consensus panel. Six of the most crucial and relevant areas of debate regarding the management of mPC were identified...
December 6, 2017: BJU International
https://www.readbyqxmd.com/read/29205840/multiple-level-porous-polymer-monoliths-with-interconnected-cellular-topology-prepared-by-combining-hard-sphere-and-emulsion-templating-for-use-in-bone-tissue-engineering
#6
Muzafera Paljevac, Lidija Gradišnik, Saška Lipovšek, Uroš Maver, Jiři Kotek, Peter Krajnc
A combination of hard sphere and high internal phase emulsion templating gives a platform for synthesizing hierarchically porous polymers with a unique topology exhibiting interconnected spherical features on multiple levels. Polymeric spheres are fused by thermal sintering to create a 3D monolithic structure while an emulsion with a high proportion of internal phase and monomers in the continuous phase is added to the voids of the previously constructed monolith. Following polymerization of the emulsion and dissolution of the templating structure, a down-replicating topology is created with a primary level of pores as a result of fused spheres of the 3D monolithic structure, a secondary level of pores resulting from the emulsion's internal phase, and a tertiary level of interconnecting channels...
December 4, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29196208/eradicate-a-prospective-evaluation-combining-radium-223-dichloride-and-abiraterone-acetate-plus-prednisone-in-patients-with-castration-resistant-prostate-cancer
#7
Neal D Shore, Ronald F Tutrone, Neil F Mariados, Luke T Nordquist, Bryan A Mehlhaff, Karyn J Steere, Stacey S Harrelson
BACKGROUND: Multiple castration-resistant prostate cancer (CRPC) therapies are approved by the United States Food and Drug Administration. Radium-223 dichloride (Ra-223) with abiraterone acetate plus prednisone have different mechanisms of action and distinct off-target side-effect profiles. We prospectively investigated their combined safety, tolerability, and patient-reported outcome measures. PATIENTS AND METHODS: eRADicAte, an investigator-initiated, phase II trial, studied 31 patients with metastatic CRPC, from 5 United States uro-oncology research sites...
November 7, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29188296/association-of-cerebral-amyloid-%C3%AE-aggregation-with-cognitive-functioning-in-persons-without-dementia
#8
Willemijn J Jansen, Rik Ossenkoppele, Betty M Tijms, Anne M Fagan, Oskar Hansson, William E Klunk, Wiesje M van der Flier, Victor L Villemagne, Giovanni B Frisoni, Adam S Fleisher, Alberto Lleó, Mark A Mintun, Anders Wallin, Sebastiaan Engelborghs, Duk L Na, Gäel Chételat, José Luis Molinuevo, Susan M Landau, Niklas Mattsson, Johannes Kornhuber, Osama Sabri, Christopher C Rowe, Lucilla Parnetti, Julius Popp, Tormod Fladby, William J Jagust, Pauline Aalten, Dong Young Lee, Rik Vandenberghe, Catarina Resende de Oliveira, Elisabeth Kapaki, Lutz Froelich, Adrian Ivanoiu, Tomasz Gabryelewicz, Marcel M Verbeek, Páscual Sanchez-Juan, Helmut Hildebrandt, Vincent Camus, Marzena Zboch, David J Brooks, Alexander Drzezga, Juha O Rinne, Andrew Newberg, Alexandre de Mendonça, Marie Sarazin, Gil D Rabinovici, Karine Madsen, Milica G Kramberger, Agneta Nordberg, Vincent Mok, Barbara Mroczko, David A Wolk, Philipp T Meyer, Magda Tsolaki, Philip Scheltens, Frans R J Verhey, Pieter Jelle Visser, Dag Aarsland, Daniel Alcolea, Myriam Alexander, Ina S Almdahl, Steven E Arnold, Inês Baldeiras, Henryk Barthel, Bart N M van Berckel, Kaj Blennow, Mark A van Buchem, Enrica Cavedo, Kewei Chen, Elena Chipi, Ann D Cohen, Stefan Förster, Juan Fortea, Kristian S Frederiksen, Yvonne Freund-Levi, Olymbia Gkatzima, Mark Forrest Gordon, Timo Grimmer, Harald Hampel, Lucrezia Hausner, Sabine Hellwig, Sanna-Kaisa Herukka, Peter Johannsen, Aleksandra Klimkowicz-Mrowiec, Sebastian Köhler, Norman Koglin, Koen van Laere, Mony de Leon, Viviana Lisetti, Wolfgang Maier, Jan Marcusson, Olga Meulenbroek, Hanne M Møllergård, John C Morris, Arto Nordlund, Gerald P Novak, George P Paraskevas, Gayan Perera, Oliver Peters, Inez H G B Ramakers, Lorena Rami, Eloy Rodríguez-Rodríguez, Catherine M Roe, Uros Rot, Eckart Rüther, Isabel Santana, Johannes Schröder, Sang W Seo, Hilkka Sorininen, Luiza Spiru, Erik Stomrud, Hanne Struyfs, Charlotte E Teunissen, Stephanie J B Vos, Linda J C van Waalwijk van Doorn, Gunhild Waldemar, Åsa K Wallin, Jens Wiltfang, Henrik Zetterberg
Importance: Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials. Objective: To investigate whether amyloid-β aggregation is associated with cognitive functioning in persons without dementia. Design, Setting, and Participants: This cross-sectional study included 2908 participants with normal cognition and 4133 with mild cognitive impairment (MCI) from 53 studies in the multicenter Amyloid Biomarker Study...
November 29, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29187381/crrl269-a-novel-designer-and-renal-enhancing-pgc-a-peptide-activator
#9
Yang Chen, Gail J Harty, Brenda K Huntley, Seethalakshmi R Iyer, Denise M Heublein, Gerald E Harders, Laura M G Meems, Shuchong Pan, S Jeson Sangaralingham, Tomoko Ichiki, John C Burnett
AIMS: The natriuretic peptides (NPs) b-type NP (BNP) and urodilatin (URO) exert renal protective properties via the particulate guanylyl cyclase A receptor (pGC-A). As a potential renal enhancing strategy, we engineered a novel designer peptide that we call CRRL269. CRRL269 was investigated in human cell lines and in normal canines to define potential cardiorenal enhancing actions. The mechanism of its cardiorenal selective properties was also investigated. METHODS AND RESULTS: In vitro NP receptor activity was quantified with 3', 5' cyclic guanosine monophosphate (cGMP) generation...
November 29, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29185631/-myths-and-reality-about-immunonutrition-in-uro-oncology
#10
Yannick Cerantola
Postoperative morbidity remains a nightmare (although vivid), both for the patient and the surgeon. One phantasmagorical idea would be to give the patient a « magic potion » preoperatively aiming at eliminating the risk of postoperative complication. The purpose of the present review is to summarize the current knowledge on the potential benefits of immunonutrition administered to urological cancers patients. After a brief summary on the role of immunity in cancer surveillance and treatment, the rationale about administrating oral nutritional supplements able to modulate the patient's immune system before cystectomy for bladder cancer will be highlighted...
November 29, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29185472/computational-and-nmr-spectroscopy-insights-into-the-conformation-of-cyclic-di-nucleotides
#11
Baifan Wang, Zhenghua Wang, Uroš Javornik, Zhen Xi, Janez Plavec
Cyclic di-nucleotides (CDNs) are second messengers in bacteria and metazoan that are as such controlling important biological processes. Here the conformational space of CDNs was explored systematically by a combination of extensive conformational search and DFT calculations as well as NMR methods. We found that CDNs adopt pre-organized conformations in solution in which the ribose conformations are North type and glycosidic bond conformations are anti type. The overall flexibility of CDNs as well as the backbone torsion angles depend on the cyclization of the phosphodiester bond...
November 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29178439/renal-parenchyma-impairment-characterization-in-partial-unilateral-ureteral-obstruction-in-mice-with-intravoxel-incoherent-motion-mri
#12
Maguelonne Pons, Benjamin Leporq, Liza Ali, Marianne Alison, Miguel Albuquerque, Michel Peuchmaur, Marie-Laurence Poli Mérol, Ulrich Blank, Simon A Lambert, Alaa El Ghoneimi
Ureteropelvic junction obstruction constitutes a major cause of progressive pediatric renal disease. The biological mechanisms underlying the renal response to obstruction can be investigated using a clinically relevant mouse model of partial unilateral ureteral obstruction (pUUO). Renal function and kidney morphology data can be evaluated using renal ultrasound, scintigraphy and uro-magnetic resonance imaging (uro-MRI), but these methods are poorly linked to histological change and not all are quantitative...
November 27, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29176310/urinary-disorders-and-marfan-syndrome-a-series-of-4-cases
#13
Claire Hentzen, Nicolas Turmel, Camille Chesnel, Frederique Le Breton, Samer Sheikh Ismael, Gérard Amarenco
Marfan syndrome is a genetic disease responsible for causing cardiovascular, eye and musculoskeletal damages. Urinary disorders are not common. We present 4 cases of chronic urinary tract symptoms, with 2 different pathophysiological processes. Three patients presented with spinal cord infarct following aortic dissection surgery. They were affected by an overactive bladder with detrusor overactivity and detrusor-sphincter dyssynergia. One patient complained of voiding dysfunction, possibly related to dural ectasia...
November 24, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29175657/a-combined-variable-temperature-600%C3%A2-mhz-nmr-md-study-of-the-calcium-release-agent-cyclic-adenosine-diphosphate-ribose-cadpr-structure-conformational-analysis-and-thermodynamics-of-the-conformational-equilibria
#14
Uroš Javornik, Janez Plavec, Baifan Wang, Steven M Graham
A combined variable temperature 600 MHz NMR/molecular dynamics study of the Ca2+-release agent cyclic adenosine 5'-diphosphate ribose (cADPR) was conducted. In addition to elucidating the major and minor orientations of the conformationally flexible furanose rings, γ- (C4'-C5'), and β- (C5'-O5') bonds, the thermodynamics (ΔHo, ΔSo) associated with each of these conformational equilibria were determined. Both furanose rings were biased towards a south conformation (64-74%) and both β-bonds heavily favored trans conformations...
November 15, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29172692/phenolic-profiles-of-serbian-autochthonous-variety-prokupac-and-monovarietal-international-wines-from-the-central-serbia-wine-region
#15
Milica Pantelić, Dragana Dabić Zagorac, Uroš Gašić, Sonja Jović, Zoran Bešlić, Slavica Todić, Maja Natić
Phenolic profiles of young monovarietal white and red wines from the Central Serbia were investigated. Quantification of phenolics was done using ultra-high-performance liquid chromatography (UHPLC) coupled with a diode array detector and a triple-quadrupole mass spectrometer. Generally, red wines were characterised with higher phenolics content when compared to the white wines. This applies also for the total phenolics content (TPC) and radical scavenging activity (RSA) values. Among all the samples, the red wine from autochthonous Serbian variety 'Prokupac' stood out with unique composition, showing the highest TPC, RSA and the highest concentration of the individual phenolics...
November 26, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29158860/using-equitable-impact-sensitive-tool-equist-and-knowledge-translation-to-promote-evidence-to-policy-link-in-maternal-and-child-health-report-of-first-equist-training-workshop-in-nigeria
#16
Chigozie Jesse Uneke, Issiaka Sombie, Henry Chukwuemeka Uro-Chukwu, Ermel Johnson, Friday Okonofua
The Equitable Impact Sensitive Tool (EQUIST) designed by UNICEF and knowledge translation (KT) are important strategies that can help policymakers to improve equity and evidence-informed policy making in maternal, newborn and child health (MNCH). The purpose of this study was to improve the knowledge and capacity of an MNCH implementation research team (IRT) and policy makers to use EQUIST and KT. A modified "before and after" intervention study design was used in which outcomes were measured on the target participants both before the intervention (workshop) is implemented and after...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29126846/sexual-function-and-quality-of-life-in-adult-male-individuals-with-exstrophy-epispadias-complex-a-survey-of-the-german-cure-network
#17
J Traceviciute, N Zwink, E Jenetzky, H Reutter, K Hirsch, R Stein, W H Rösch, A K Ebert
OBJECTIVE: To investigate sexual function and quality of life (QoL) in adult male individuals with exstrophy-epispadias complex (EEC). Data from the German network for congenital uro-rectal malformations (CURE-Net) were used. PATIENTS AND METHODS: 51 males (≥18 years) recruited by CURE-Net between 2009 and 2012 were re-contacted per mail and asked to fill out four questionnaires including International Index of Erectile Function (IIEF-5), Cologne assessment of Erectile Dysfunction (KEED), the Short-Form 36 (SF-36) and one self-designed questionnaire about their medical history, current health status, sexual experience...
November 7, 2017: Urology
https://www.readbyqxmd.com/read/29124101/data-set-of-proteomic-analysis-of-food-borne-pathogens-after-treatment-with-the-disinfectants-based-on-pyridoxal-oxime-derivatives
#18
Martina Gajdošik Šrajer, Uroš Andjelković, Dajana Gašo-Sokač, Hrvoje Pavlović, Olga Shevchuk, Tamara Martinović, James Clifton, Djuro Josić
Food borne pathogens, namely the Gram-positive bacterium Bacillus subtilis and the Gram-negative bacterium Escherichia coli, were grown under the inhibition with four different disinfectants based on chloride and bromide salts of pyridinium oxime. Bacterial samples were subjected to the sequential extraction of proteins and the in-solution tryptic digestion of obtained extracts was performed prior to the identification of proteins with LC-ESI-MS/MS. Proteomic analysis identified up- and down-regulated proteins in these bacteria after treatment with each compound...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29117233/dietary-amino-acid-and-vitamin-complex-protects-honey-bee-from-immunosuppression-caused-by-nosema-ceranae
#19
Uros Glavinic, Biljana Stankovic, Vladimir Draskovic, Jevrosima Stevanovic, Tamas Petrovic, Nada Lakic, Zoran Stanimirovic
Microsporidium Nosema ceranae is well known for exerting a negative impact on honey bee health, including down-regulation of immunoregulatory genes. Protein nutrition has been proven to have beneficial effects on bee immunity and other aspects of bee health. Bearing this in mind, the aim of our study was to evaluate the potential of a dietary amino acid and vitamin complex "BEEWELL AminoPlus" to protect honey bees from immunosuppression induced by N. ceranae. In a laboratory experiment bees were infected with N...
2017: PloS One
https://www.readbyqxmd.com/read/29116393/reconsidering-the-role-of-pelvic-lymph-node-dissection-with-radical-prostatectomy-for-prostate-cancer-in-an-era-of-improving-radiological-staging-techniques
#20
J W Yaxley, J Dagher, B Delahunt, L Egevad, J Srigley, H Samaratunga
BACKGROUND: Performing an extended pelvic lymph node dissection (PLND) on all men with intermediate- and high-risk prostate cancer at the time of a radical prostatectomy (RP) remains controversial. The majority of patients PLND histology is benign, and the long-term cancer-free progression in men with positive lymph node metastasis is low. The objective is to investigate the probability of long-term biochemical freedom from recurrent disease (bNED) in men with lymph node metastasis identified at the time of radical prostatectomy (RP)...
November 7, 2017: World Journal of Urology
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