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https://www.readbyqxmd.com/read/28527184/polyphenols-as-possible-markers-of-botanical-origin-of-honey
#1
Uroš M Gašić, Dušanka M Milojković-Opsenica, Živoslav Lj Tešić
In recent years, the botanical and geographical origin of food has become an important topic in the context of food quality and safety, as well as consumer protection, in accordance with international standards. Finding chemical markers, especially phytochemicals, characteristic for some kind of food is the subject of interest of a significant number of researchers in the world. This paper is focused on the use of polyphenols as potential markers for the determination of botanical origin of honey. It includes a review of the polyphenols present in various honey samples and the methods for their separation and identification...
May 19, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28510805/interventional-radiology-in-iatrogenic-ureteral-leaks-case-series-and-literature-review
#2
Claudia Trombatore, Giuseppe Giordano, Vincenzo Magnano San Lio
Iatrogenic ureteral injuries are a dramatic complication in medical practice. Nowadays there are no universal guidelines for their management. The aim of our study was to evaluate the feasibility of the percutaneous treatment in restoring ureteral integrity in 19 patients that came to our attention. In each case retrograde stenting failed and patients were candidates for re-surgery. Our strategy consists of two phases. The first step is the nephrostomy that allows an external urinary diversion putting dry the damaged ureteral segment...
May 16, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28503786/use-of-fluorescent-in-situ-hybridisation-in-salivary-gland-cytology-a-powerful-diagnostic-tool
#3
S M Evrard, J Meilleroux, G Daniel, C Basset, L Lacoste-Collin, S Vergez, E Uro-Coste, M Courtade-Saidi
OBJECTIVE: Salivary gland cytology is challenging because it includes a diversity of lesions and a wide spectra of tumours. Recently, it has been reported that many types of salivary gland tumours have specific molecular diagnostic signatures that could be identified by fluorescent in-situ hybridisation (FISH). The aim of the present study was to demonstrate the feasibility and efficiency of FISH on routine cytological salivary gland smears. METHODS: FISH was conducted on 37 cytological salivary gland smears from 34 patients...
May 15, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28494091/fermentation-characteristics-and-aromatic-profile-of-plum-wines-produced-with-indigenous-microbiota-and-pure-cultures-of-selected-yeast
#4
Uroš Miljić, Vladimir Puškaš, Vesna Vučurović, Ana Muzalevski
The aim of this study was to assess and compare fermentation characteristics and aromatic profile of plum wines produced with indigenous microbiota and pure cultures of different selected yeast. Experiments were carried out with plum (Prunus domestica L.) varieties of different fruit ripening times (Čačanska rana, Čačanska lepotica, and Požegača). Wine fermentations were conducted by the activity of indigenous microbiota, commercially available Saccharomyces cerevisiae and Saccharomyces bayanus yeast strains and joint activity of Schizosaccharomyces pombe and S...
May 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28478854/efficacy-of-preoperative-uro-stoma-education-on-self-efficacy-after-radical-cystectomy-secondary-outcome-of-a-prospective-randomized-controlled-trial
#5
Bente Thoft Jensen, Berit Kiesbye, Ingrid Soendergaard, Jørgen B Jensen, Susanne Ammitzboell Kristensen
PURPOSE: Radical Cystectomy with a creation of an uro-stoma is first line treatment in advanced bladder-cancer. Enhancing or maintaining an individual's condition, skills and physical wellbeing before surgery has been defined as prehabilitation. Whether preoperative stoma-education is an effective element in prehabilitation is yet to be documented. In a prospective randomized controlled design (RCT) the aim was to investigate the efficacy of a standardised preoperative stoma-education program on an individual's ability to independently change a stoma-appliance...
June 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28475490/reducing-4dcbct-imaging-time-and-dose-the-first-implementation-of-variable-gantry-speed-4dcbct-on-a-linear-accelerator
#6
Ricky T O'Brien, Uros Stankovic, Jan-Jakob Sonke, Paul J Keall
Four dimensional cone beam computed tomography (4DCBCT) uses a constant gantry speed and imaging frequency that are independent of the patient's breathing rate. Using a technique called respiratory motion guided 4DCBCT (RMG-4DCBCT), we have previously demonstrated that by varying the gantry speed and imaging frequency, in response to changes in the patient's real-time respiratory signal, the imaging dose can be reduced by 50-70%. RMG-4DCBCT optimally computes a patient specific gantry trajectory to eliminate streaking artefacts and projection clustering that is inherent in 4DCBCT imaging...
May 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28472281/successful-catheter-ablation-of-ventricular-ectopy-in-a-young-patient-with-implanted-melody-valve
#7
Matevž Jan, David Žižek, Uroš Mazic, Luka Klemen, Gordan Mijovski, Petr Peichl
No abstract text is available yet for this article.
May 4, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28458749/what-false-negative-rates-of-non-invasive-testing-are-active-surveillance-patients-and-uro-oncologists-willing-to-accept-in-order-to-avoid-prostate-biopsy
#8
Rashid Khalid Sayyid, Dharmendra Dingar, Katherine Fleshner, Taylor Thorburn, Joshua Diamond, Erik Yao, Karen Hersey, Karen Chadwick, Nathan Perlis, Laurence Klotz, Antonio Finelli, Robert Hamilton, Girish Kulkarni, Alexandre Zlotta, Neil Fleshner
INTRODUCTION: Repeat prostate biopsies in active surveillance patients are associated with significant complications. Novel imaging and blood/urine-based non-invasive tests are being developed to better predict disease grade and volume progression. We conducted a theoretical study to determine what test performance characteristics and costs would a non-invasive test(s) require in order for patients and their physicians to comfortably avoid biopsy. METHODS: Surveys were administered to two populations to determine an acceptable false-negative rate and cost for such test(s)...
March 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28458485/phenotypic-detection-of-extended-spectrum-beta-lactamase-and-carbapenemase-co-producing-clinical-isolates-from-two-tertiary-hospitals-in-kano-north-west-nigeria
#9
Yusuf Ibrahim, Yahaya Sani, Qabli Saleh, Algarni Saleh, Gbadamosi Hakeem
BACKGROUND: Continue rise in unprofessional use of antibiotics in our hospitals and communities is worrisome. A research study was therefore conducted to detect extended spectrum beta-lactamase (ESBL), carbapenemase, metallobeta lactamase and their co-production phenotypically from isolates obtained from patients admitted to or attending two tertiary hospitals in Kano, Nigeria. METHOD: A total of 248 isolates of Escherichia coli and Klebsiella pneumoniaewere screened phenotypically for ESBL production and carbapenemase production according to CLS1 2012 breakpoints using double disk synergy test and modified Hodge test (MHT) respectively...
January 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/28453747/natural-course-and-prognosis-of-anaplastic-gangliogliomas-a-multicenter-retrospective-study-of-43-cases-from-the-french-brain-tumor-database
#10
Louis-Marie Terrier, Luc Bauchet, Valérie Rigau, Aymeric Amelot, Sonia Zouaoui, Isabelle Filipiak, Agnès Caille, Fabien Almairac, Marie-Hélène Aubriot-Lorton, Anne-Marie Bergemer-Fouquet, Eric Bord, Philippe Cornu, Alain Czorny, Phong Dam Hieu, Bertrand Debono, Marie-Bernadette Delisle, Evelyne Emery, Walid Farah, Guillaume Gauchotte, Catherine Godfraind, Jacques Guyotat, Bernard Irthum, Kevin Janot, Pierre-Jean Le Reste, Dominique Liguoro, Hugues Loiseau, Guillaume Lot, Vincent Lubrano, Emmanuel Mandonnet, Philippe Menei, Philippe Metellus, Serge Milin, Bertrand Muckenstrum, Pierre-Hugues Roche, Audrey Rousseau, Emmanuelle Uro-Coste, Anne Vital, Jimmy Voirin, Michel Wager, Marc Zanello, Patrick François, Stéphane Velut, Pascale Varlet, Dominique Figarella-Branger, Johan Pallud, Ilyess Zemmoura
Background.: Anaplastic gangliogliomas (GGGs) are rare tumors whose natural history is poorly documented. We aimed to define their clinical and imaging features and to identify prognostic factors. Methods.: Consecutive cases of anaplastic GGGs in adults prospectively entered into the French Brain Tumor Database between March 2004 and April 2014 were screened. After diagnosis was confirmed by pathological review, clinical, imaging, therapeutic, and outcome data were collected retrospectively...
May 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28452957/mycotoxin-decontamination-of-food-cold-atmospheric-pressure-plasma-versus-classic-decontamination
#11
REVIEW
Nataša Hojnik, Uroš Cvelbar, Gabrijela Tavčar-Kalcher, James L Walsh, Igor Križaj
Mycotoxins are secondary metabolites produced by several filamentous fungi, which frequently contaminate our food, and can result in human diseases affecting vital systems such as the nervous and immune systems. They can also trigger various forms of cancer. Intensive food production is contributing to incorrect handling, transport and storage of the food, resulting in increased levels of mycotoxin contamination. Mycotoxins are structurally very diverse molecules necessitating versatile food decontamination approaches, which are grouped into physical, chemical and biological techniques...
April 28, 2017: Toxins
https://www.readbyqxmd.com/read/28451781/13-novel-putative-mutations-in-atp7a-found-in-a-cohort-of-25-italian-families
#12
Paola de Gemmis, Maria Vittoria Enzo, Elisa Lorenzetto, Paola Cattelan, Daniela Segat, Uros Hladnik
ATP7A is a copper-transporting P-type adenosine triphosphatase whose loss of function leads to the Menkes disease, an X-linked copper metabolism multi-organ disorder (1 in 100.000 births). Here we document our experience with the ATP7A linked diseases in Italy. We analyzed the exonic structure of the ATP7A gene in 25 unrelated Italian families and studied the variants of unknown significance. We identified 22 different DNA alterations, 13 of which first reported in this study. The classical Menkes phenotype was present in 21 of the 25 families and was linked with highly damaging mutations (7 nonsense; 4 frame-shift; 2 small in-frame deletions, 2 splice site alterations, 2 gross deletions, and 1 gross duplication)...
April 28, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28448798/chemodiversity-of-two-closely-related-tetraploid-centaurium-species-and-their-hexaploid-hybrid-metabolomic-search-for-high-resolution-taxonomic-classifiers
#13
Tijana Banjanac, Milan Dragićević, Branislav Šiler, Uroš Gašić, Borut Bohanec, Jasmina Nestorović Živković, Snežana Trifunović, Danijela Mišić
Species within the genus Centaurium readily hybridize and polyploid complexes are often seen in natural populations. We describe phytochemical profiles of newly discovered allohexaploid hybrid, here named Centaurium pannonicum, and its parental tetraploid species C. erythraea and rare C. littorale ssp. compressum. Our aim was to examine chemodiversity of these taxa in the area of Vojvodina (North Serbia) and to perform metabolomics search for chemical classifiers which would provide high resolution discrimination of parental and hybrid individuals...
April 24, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28444193/quantitative-assessment-of-timing-efficiency-specificity-and-genetic-mosaicism-of-crispr-cas9-mediated-gene-editing-of-hemoglobin-beta-gene-in-rhesus-monkey-embryos
#14
Uros Midic, Pei-Hsuan Hung, Kailey A Vincent, Benjamin Goheen, Patrick G Schupp, Diane D Chen, Daniel E Bauer, Catherine A VandeVoort, Keith E Latham
Gene editing technologies offer new options for developing novel biomedical research models and for gene and stem cell based therapies. However, applications in many species demand high efficiencies, specificity, and a thorough understanding of likely editing outcomes. To date, overall efficiencies, rates of off-targeting, and degree of genetic mosaicism have not been well-characterized for most species, limiting our ability to optimize methods. As a model gene for measuring these parameters of CRISPR/Cas9 application in a primate species (rhesus monkey), we selected the β-hemoglobin gene (HBB), which also has high relevance to potential application of gene editing and stem-cell technologies for treating human disease...
April 21, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28424082/subventricular-zones-new-key-targets-for-glioblastoma-treatment
#15
J Khalifa, F Tensaouti, A Lusque, B Plas, J-A Lotterie, A Benouaich-Amiel, E Uro-Coste, V Lubrano, E Cohen-Jonathan Moyal
BACKGROUND: We aimed to identify subventricular zone (SVZ)-related prognostic factors of survival and patterns of recurrence among patients with glioblastoma. METHODS: Forty-three patients with primary diagnosed glioblastoma treated in our Cancer Center between 2006 and 2010 were identified. All patients received surgical resection, followed by temozolomide-based chemoradiation. Ipsilateral (iSVZ), contralateral (cSVZ) and bilateral (bSVZ) SVZs were retrospectively segmented and radiation dose-volume histograms were generated...
April 20, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28413077/trichomonosis-outbreak-in-a-flock-of-canaries-serinus-canaria-f-domestica-caused-by-a-finch-epidemic-strain-of-trichomonas-gallinae
#16
Marko Zadravec, Brigita Slavec, Uroš Krapež, Mitja Gombač, Tanja Švara, Mateja Poljšak-Prijatelj, Igor Gruntar, Joško Račnik
In the present paper, an outbreak of trichomonosis in a flock of 15 breeding pairs of canaries is described. Trichomonosis was diagnosed on characteristic clinical signs, microscopic examination of crop/esophageal swabs, gross pathology and histopathology. Trichomonads were successfully grown in culture media and were characterized by multi-locus sequence typing. The three genomic loci ITS1-5.8S-ITS2, 18S rRNA and Fe-hydrogenase were analyzed. Molecular characterization confirmed the finch trichomonosis strain, identical to the strain that caused emerging disease in free-living passerine birds in Europe...
April 3, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28398630/mitigating-differential-baseline-shifts-in-locally-advanced-lung-cancer-patients-using-an-average-anatomy-model
#17
Mehrsima Abdoli, Simon R van Kranen, Uros Stankovic, Maddalena M G Rossi, Jose S A Belderbos, Jan-Jakob Sonke
BACKGROUND AND PURPOSE: Differential baseline shifts between primary tumor and involved lymph nodes in locally advanced lung cancer patients compromise the accuracy of radiotherapy. The purpose of this study was to evaluate the performance of an average anatomy model (AAM) derived from repeat imaging and deformable registration to reduce these geometrical uncertainties. METHODS AND MATERIALS: An in-house implementation of a B-Spline deformable image registration (DIR) algorithm was first validated using three different validation approaches: 1) a circle method to test the consistency of the DIR, 2) fiducial marker target registration error, and 3) the recovery of a known deformation vector field (DVF)...
April 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28385244/novel-ethanol-induced-pectin-xanthan-aerogel-coatings-for-orthopedic-applications
#18
Gabrijela Horvat, Klodian Xhanari, Matjaž Finšgar, Lidija Gradišnik, Uroš Maver, Željko Knez, Zoran Novak
In this study, we developed a novel high methoxyl pectin-xanthan aerogel coating on medical-grade stainless steel, prepared by ethanol-induced gelation and subsequent supercritical drying. Two non-steroidal anti-inflammatory drugs, i.e. diclofenac sodium and indomethacin, were incorporated into the aerogel coating. Electrochemical analyses were performed on the coated samples using electrochemical impedance spectroscopy and cyclic polarization techniques. The results showed that all passivated samples were highly resistant to general corrosion...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28379998/safety-aspects-of-atmospheric-pressure-helium-plasma-jet-operation-on-skin-in-vivo-study-on-mouse-skin
#19
Spela Kos, Tanja Blagus, Maja Cemazar, Gregor Filipic, Gregor Sersa, Uros Cvelbar
Biomedical applications of plasma require its efficacy for specific purposes and equally importantly its safety. Herein the safety aspects of cold plasma created with simple atmospheric pressure plasma jet produced with helium gas and electrode discharge are evaluated in skin damage on mouse, at different duration of exposure and gas flow rates. The extent of skin damage and treatments are systematically evaluated using stereomicroscope, labelling with fluorescent dyes, histology, infrared imaging and optical emission spectroscopy...
2017: PloS One
https://www.readbyqxmd.com/read/28378523/impact-of-somatic-copy-number-alterations-on-the-glioblastoma-mirnome-mir-4484-is-a-genomically-deleted-tumour-suppressor
#20
Zahid Nawaz, Vikas Patil, Sivaarumugam Thinagararjan, Soumya A Rao, Alangar S Hegde, Arimappamagan Arivazhagan, Vani Santosh, Kumaravel Somasundaram
Glioblastoma (GBM) is the most frequent and most malignant primary brain tumour in adults. GBMs have a unique landscape of somatic copy number alterations (SCNAs), with the concomitant appearance of numerous driver amplifications and deletions. Here, we examined the genomic regions harbouring SCNAs and their impact on the GBM miRNome. We found that 40% of SCNA events covering 70-88% of the genomically altered regions, as identified by GISTIC and RAE algorithms, carried miRNA genes. Out of 1426 annotated mature miRNAs analysed, ~ 14% (n=198) were mapped to such fragile loci...
April 5, 2017: Molecular Oncology
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