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https://www.readbyqxmd.com/read/29909236/antiepileptic-drugs-as-analgesics-adjuvants-in-inflammatory-pain-current-preclinical-evidence
#1
REVIEW
Tomić Maja, Pecikoza Uroš, Micov Ana, Vučković Sonja, Stepanović-Petrović Radica
Inflammatory pain is the most common type of pain that is treated clinically. The use of currently available treatments (classic analgesics - NSAIDs, paracetamol and opioids) is limited by insufficient efficacy and/or side effects/tolerance development. Antiepileptic drugs (AEDs) are widely used in neuropathic pain treatment, but there is substantial preclinical evidence on their efficacy against inflammatory pain, too. In this review we focus on gabapentinoids (gabapentin and pregabalin) and dibenzazepine AEDs (carbamazepine, oxcarbazepine, and recently introduced eslicarbazepine acetate) and their potential for relieving inflammatory pain...
June 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29901294/-evaluation-of-upper-urinary-tract-function-in-patients-undergoing-autoplastic-surgery-for-hydronphrosis-of-the-intrarenal-pelvis
#2
R M Kurbanaliev, A Ch Usupbaev, I V Kolesnichenko, N Zh Sadyrbekov, B M Sultanov
AIM: To investigate the functional state of the upper urinary tract in patients undergoing autoplastic surgery for a hydronophrosis of the intrarenal pelvis. MATERIAL AND METHODS: The study comprised 78 patients with the intrarenal pelvis and impaired urinary outflow due to stricture of the ureteropelvic junction and vascular conflict (interatrial and arteriovenous narrowing), who underwent pyeloplasty using autologous tunica vaginalis. All patients underwent an incision of ureteropelvic stricture and resection of the parietal layer of the tunica vaginalis which was used to repair the obstruction site and internal stenting of the upper urinary tract...
May 2018: Urologii︠a︡
https://www.readbyqxmd.com/read/29900695/novel-key-roles-for-structural-maintenance-of-chromosome-flexible-domain-containing-1-smchd1-during-preimplantation-mouse-development
#3
Uros Midic, Kailey A Vincent, Kai Wang, Alyson Lokken, Ashley L Severance, Amy Ralston, Jason G Knott, Keith E Latham
Structural maintenance of chromosome flexible domain containing 1 (Smchd1) is a chromatin regulatory gene for which mutations are associated with facioscapulohumeral muscular dystrophy and arhinia. The contribution of oocyte- and zygote-expressed SMCHD1 to early development was examined in mice (Mus musculus) using an siRNA knockdown approach. Smchd1 knockdown compromised long-term embryo viability, with reduced embryo nuclear volumes at the morula stage, reduced blastocyst cell number, formation and hatching, and reduced viability to term...
June 13, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29893161/validation-of-a-tennis-rating-score-to-evaluate-the-technical-level-of-children-tennis-players
#4
Luka Šlosar, Boštjan Šimunič, Rado Pišot, Uros Marusic
The purpose of this study was to create a valid and reliable assessment scale for the evaluation of three basic tennis strokes (forehand, backhand, serve) for 6-12-year-old tennis players, named the Tennis Rating Score for Children (TRSC). Altogether 60 players (21: forehand, 22: backhand, 17: serve) were video recorded (30 frames per second) while performing three main tennis strokes and later evaluated using the TRSC by five tennis trainers at Day 1 and Day 7. Agreement between days and raters was examined using the intraclass correlation coefficients (ICC)...
June 12, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29881278/unplanned-reoperation-after-radical-gastrectomy-for-gastric-cancer-causes-risk-factors-and-long-term-prognostic-influence
#5
Xueliang Zuo, Juan Cai, Zhiqiang Chen, Yao Zhang, Jian Wu, Liangyu Wu, Jinguo Wang
Purpose: Unplanned reoperation (URO) after radical gastrectomy for gastric cancer (GC) mostly results from serious postoperative complications. At present, there is still controversy over the predictive factors for URO. Our goal was to identify the risk factors for URO and to investigate its potential impact on long-term survival. Patients and methods: We included 2,852 GC patients who underwent a gastrectomy. Multivariate logistic regression analyses were performed to determine the risk factors for URO...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29866881/ethanolamine-ameliorates-mitochondrial-dysfunction-in-cardiolipin-deficient-yeast-cells
#6
Writoban Basu Ball, Charli D Baker, John K Neff, Gabriel L Apfel, Kim A Lagerborg, Gašper Žun, Uroš Petrovič, Mohit Jain, Vishal M Gohil
Cardiolipin (CL) is a signature phospholipid of the mitochondria required for the formation of mitochondrial respiratory chain (MRC) supercomplexes. The destabilization of MRC supercomplexes is the proximal cause of the pathology associated with the depletion of CL in patients with Barth syndrome. Thus, promoting supercomplex formation could ameliorate mitochondrial dysfunction associated with CL depletion. However, to date, physiologically relevant small-molecule regulators of supercomplex formation have not been identified...
June 4, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29862992/repeated-penile-girth-enhancement-with-biodegradable-scaffolds-microscopic-ultrastructural-analysis-and-surgical-benefits
#7
Miroslav L Djordjevic, Uros Bumbasirevic, Borko Stojanovic, Tamara Kravic Stevovic, Tamara Martinovic, Marta Bizic, Vladimir Kojovic
Autologous tissue engineering using biodegradable scaffolds as a carrier is a well-known procedure for penile girth enhancement. We evaluated a group of previously treated patients with the aim to analyze histomorphometric changes after tissue remodeling and to estimate the benefits of repeated procedure. Between February 2012 and December 2016, a group of 21 patients, aged 22-37 (mean 28.0) years, underwent a repeated penile girth enhancement procedure with biodegradable scaffolds. Procedure included insertion of two poly-lactic-co-glycolic acid scaffolds seeded with laboratory-prepared fibroblasts from scrotal tissue specimens...
June 1, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29844402/improved-fermentation-efficiency-of-s-cerevisiae-by-changing-glycolytic-metabolic-pathways-with-plasma-agitation
#8
Nina Recek, Renwu Zhou, Rusen Zhou, Valentino Setoa Junior Te'o, Robert E Speight, Miran Mozetič, Alenka Vesel, Uros Cvelbar, Kateryna Bazaka, Kostya Ken Ostrikov
Production of ethanol by the yeast Saccharomyces cerevisiae is a process of global importance. In these processes, productivities and yields are pushed to their maximum possible values leading to cellular stress. Transient and lasting enhancements in tolerance and performance have been obtained by genetic engineering, forced evolution, and exposure to moderate levels of chemical and/or physical stimuli, yet the drawbacks of these methods include cost, and multi-step, complex and lengthy treatment protocols...
May 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29843731/tyrphostin-ag17-inhibits-adipocyte-differentiation-in-vivo-and-in-vitro
#9
Alberto Camacho, Juan Carlos Segoviano-Ramírez, Adriana Sánchez-Garcia, Jose de Jesus Herrera-de la Rosa, Jaime García-Juarez, Carlos Alberto Hernandez-Puente, Geovana Calvo-Anguiano, Sergio Rodolfo Maltos-Uro, Alejandra Olguin, Gabriel Gojon-Romanillos, Gabriel Gojon-Zorrilla, Rocio Ortiz-Lopez
BACKGROUND: Excessive subcutaneous adiposity in obesity is associated to positive white adipocyte tissue (WAT) differentiation (adipogenesis) and WAT expandability. Here, we hypothesized that supplementation with the insulin inhibitor and mitochondrial uncoupler, Tyrphostin (T-AG17), in vitro and in vivo inhibits adipogenesis and adipocyte hypertrophy. METHODS: We used a 3T3-L1 proadipocyte cell line to identify the potential effect of T-AG17 on adipocyte differentiation and fat accumulation in vitro...
May 29, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29802051/transurethral-resection-of-bladder-tumors-next-generation-virtual-reality-training-for-surgeons
#10
Eva Neumann, Julian Mayer, Giorgio Ivan Russo, Bastian Amend, Steffen Rausch, Susanne Deininger, Niklas Harland, Inês Anselmo da Costa, Jörg Hennenlotter, Arnulf Stenzl, Stephan Kruck, Jens Bedke
BACKGROUND: The number of virtual reality (VR) simulators is increasing. The aim of this prospective trial was to determine the benefit of VR cystoscopy (UC) and transurethral bladder tumor resection (TURBT) training in students. DESIGN, SETTING, AND PARTICIPANTS: Medical students without endoscopic experience (n=51, median age=25 yr, median 4th academic year) were prospectively randomized into groups A and B. After an initial VR-UC and VR-TURBT task, group A (n=25) underwent a video-based tutorial by a skilled expert...
May 22, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29795530/the-relationship-between-penile-deformity-age-psychological-bother-and-erectile-dysfunction-in-a-sample-of-men-with-peyronie-s-disease-pd
#11
Andrea Burri, Hartmut Porst
The aim of the present study was to investigate which PD specific factors (e.g., degree of penile curvature, levels of pain) cause most distress and to further explore whether there are specific subgroups of patients that report particularly high levels of psychological distress. Data were available for N = 119 men with a clinical diagnosis of PD presenting at a private Uro-Andrology in Germany. The strongest complaint of men with PD was being bothered by the look of the penis as opposed to being distressed by the pain (3...
May 25, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29795201/characterization-and-origin-of-heme-precursors-in-amniotic-fluid-lessons-from-normal-and-pathological-pregnancies
#12
Hana Manceau, Vincent Puy, Caroline M Schmitt, Sophie Gil, Thibaud Lefebvre, Bichr Allaf, Jonathan Rosenblatt, Laurent Gouya, Hervé Puy, Francoise Muller, Katell Peoc'h
BACKGROUND: Heme is the prosthetic group of numerous proteins involved in vital processes such as oxygen transport, oxidative stress, and energetic mitochondrial metabolism. Free heme also plays a significant role at early stages of development and in cell differentiation processes. The metabolism of heme by the fetal placenta unit is not well-established in humans. METHODS: In a retrospective study, we measured heme precursors in the amniotic fluid (AF) of 51 healthy women, and 10 AF samples from pregnancies with either upper or lower intestinal atresia or ileus were also analyzed...
May 23, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29792937/a-reliable-targeted-next-generation-sequencing-strategy-for-diagnosis-of-myopathies-and-muscular-dystrophies-especially-for-the-giant-titin-and-nebulin-genes
#13
Reda Zenagui, Delphine Lacourt, Henri Pegeot, Kevin Yauy, Raul Juntas Morales, Corine Theze, François Rivier, Claude Cances, Guilhem Sole, Dimitri Renard, Ulrike Walther-Louvier, Xavier Ferrer-Monasterio, Caroline Espil, Marie-Christine Arné-Bes, Pascal Cintas, Emmanuelle Uro-Coste, Marie-Laure Martin Negrier, Valérie Rigau, Eric Bieth, Cyril Goizet, Mireille Claustres, Michel Koenig, Mireille Cossée
Myopathies and muscular dystrophies (M-MDs) are genetically heterogeneous diseases, with more than 100 identified genes, including the giant and complex titin (TTN) and nebulin (NEB) genes. Next-generation sequencing technology revolutionized M-MD diagnosis and revealed high frequency of TTN and NEB variants. We developed a next-generation sequencing diagnostic strategy targeted on the coding sequences of 135 M-MD genes. Comparison of two targeted capture technologies (SeqCap EZ Choice library capture kit (Roche-Nimblegen) and Nextera Rapid Capture Custom Enrichment kit (Illumina)) and of two whole exome sequencing kits (SureSelect V5 (Agilent) and TruSeq RapidExome capture (Illumina)) revealed best coverage with the SeqCap EZ Choice protocol...
May 21, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29792179/hopkins-syndrome-following-the-first-episode-of-bronchial-asthma-associated-with-enterovirus-d68-a-case-report
#14
Fumie Hayashi, Shintaro Hayashi, Dai Matsuse, Ryo Yamasaki, Keiji Yonekura, Jun-Ichi Kira
BACKGROUND: Hopkins syndrome (HS) is a rare disorder presenting with acute flaccid paralysis of the limbs following an asthma attack. Neurologists encounter a diagnostic challenge if patients without a history of bronchial asthma develop neurologic features mimicking HS following acute respiratory distress. We report a case of HS occurring after a first episode of bronchial asthma associated with enterovirus D68 infection. CASE PRESENTATION: A 5-year-old girl developed acute respiratory distress...
May 23, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29767316/-ceus-diagnosis-of-solid-renal-tumors
#15
REVIEW
K Stock, H Kübler, T Maurer, J Slotta-Huspenina, K Holzapfel
CLINICAL ISSUE: Renal lesions are detected earlier, often as a result of ultrasound examinations. However, the imaging-based differential diagnosis of different tumour entities remains challenging STANDARD RADIOLOGICAL METHODS: All renal tumours >1 cm should be evaluated for malignancy by computed tomography (CT) or magnetic resonance imaging (MRI). If an angiomyolipoma diagnosis cannot be established with imaging, further diagnostics are appropriate or if malignant progression is suspected, then multidisciplinary discussion for TNM-staging based uro-oncologic therapy is usual...
May 16, 2018: Der Radiologe
https://www.readbyqxmd.com/read/29759330/-who-classification-of-head-and-neck-tumours-2017-main-novelties-and-update-of-diagnostic-methods
#16
REVIEW
Victor Sarradin, Aurore Siegfried, Emmanuelle Uro-Coste, Jean-Pierre Delord
The publication of the new WHO classification of head and neck tumours in 2017 brought major modifications. Especially, a new chapter is dedicated to the oropharynx, focusing on the description of squamous cell carcinoma induced by the virus Human Papilloma Virus (HPV), and new entities of tumors are described in nasal cavities and sinuses. In this article are presented the novelties and main changes of this new classification, as well as the updates of the diagnostic methods (immunohistochemistry, cytogenetics or molecular biology)...
May 11, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29755513/motor-imagery-during-action-observation-of-locomotor-tasks-improves-rehabilitation-outcome-in-older-adults-after-total-hip-arthroplasty
#17
Uros Marusic, Sidney Grosprêtre, Armin Paravlic, Simon Kovač, Rado Pišot, Wolfgang Taube
This study aimed at determining whether the combination of action observation and motor imagery (AO + MI) of locomotor tasks could positively affect rehabilitation outcome after hip replacement surgery. Of initially 405 screened participants, 21 were randomly split into intervention group ( N = 10; mean age = 64 y; AO + MI of locomotor tasks: 30 min/day in the hospital, then 3×/week in their homes for two months) and control group ( N = 11, mean age = 63 y, active controls). The functional outcomes (Timed Up and Go, TUG; Four Step Square Test, FSST; and single- and dual-task gait and postural control) were measured before (PRE) and 2 months after surgery (POST)...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29749774/bladder-cancer-overview-and-disease-management-part-1-non-muscle-invasive-bladder-cancer
#18
Beverley Anderson
Part 1 of this two-part article provides an overview of bladder cancer and discusses its management. Since publication of a previous article entitled 'Understanding the role of smoking in the aetiology of bladder cancer' ( Anderson, 2009 ), the author has received many requests for an update. This article provides an overview of bladder cancer and its current management practices, underlining the continued role of smoking as the predominant risk factor in the disease's development. The management of bladder cancer is governed by specific guidelines...
May 10, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29740991/decreased-tissue-oxygenation-in-newborns-with-congenital-heart-defects-a-case-control-study
#19
Petja Fister, Domen Robek, Darja Paro-Panjan, Uroš Mazić, Helena Lenasi
AIM: To compare regional tissue oxygenation (rSO2) in the brain, intestine, and kidney between newborns with and without congenital heart defects (CHD). METHODS: This observational case-control study was conducted at the Neonatal Department of Children's Hospital Ljubljana between December 2012 and April 2014. It included 35 newborns with CHD and 30 healthy age- and sex-matched controls. CHD were assessed echocardiographically and divided into acyanotic and cyanotic group...
April 30, 2018: Croatian Medical Journal
https://www.readbyqxmd.com/read/29738172/-seminal-vesiculoscopy-past-status-quo-and-prospects
#20
Qi Wang, Liang-Gong Liao, Yan-Feng Li
Seminal vesiculoscopy is a new technology in uro-andrology developed in recent 10 years, which is a set of clinical operational techniques for observing the ejaculatory duct, seminal vesicle, ampullar region of the vas deferens and their surrounding structure, determining the cause, location and degree of the disease, and accomplishing such treatment procedures as irrigation, resection, incision, fulguration, hemostasis, expansion, drainage, and removal of hematocele, stones or obstruction in the distal seminal duct region...
November 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
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