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https://www.readbyqxmd.com/read/27846826/natural-product-htp-screening-for-antibacterial-e-coli-0157-h7-and-anti-inflammatory-agents-in-lps-from-e-coli-o111-b4-activated-macrophages-and-microglial-cells-focus-on-sepsis
#1
Elizabeth A Mazzio, Nan Li, David Bauer, Patricia Mendonca, Equar Taka, Mohammed Darb, Leeshawn Thomas, Henry Williams, Karam F A Soliman
BACKGROUND: Acute systemic inflammatory response syndrome arising from infection can lead to multiple organ failure and death, with greater susceptibility occurring in immunocompromised individuals. Moreover, sub-acute chronic inflammation is a contributor to the pathology of diverse degenerative diseases (Parkinson's disease, Alzheimer's disease and arthritis). Given the known limitations in Western medicine to treat a broad range of inflammatory related illness as well as the emergence of antibiotic resistance, there is a renewed interest in complementary and alternative medicines (CAMs) to achieve these means...
November 15, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27844057/combined-treatment-with-environmental-enrichment-and-epigallocatechin-3-gallate-ameliorates-learning-deficits-and-hippocampal-alterations-in-a-mouse-model-of-down-syndrome
#2
Silvina Catuara-Solarz, Jose Espinosa-Carrasco, Ionas Erb, Klaus Langohr, Juan Ramon Gonzalez, Cedric Notredame, Mara Dierssen
Intellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, we have demonstrated beneficial effects of a combined treatment with green tea extract containing (-)-epigallocatechin-3-gallate (EGCG) and cognitive stimulation in young adult DS individuals. Although we could reproduce the cognitive-enhancing effects in mouse models, the underlying mechanisms of these beneficial effects are unknown...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27829351/recent-updates-in-imperative-natural-compounds-for-healthy-brain-and-nerve-function-a-systematic-review-of-implications-for-multiple-sclerosis
#3
Nima Sanadgol, Shahram Shahraki Zahedani, Mohammad Sharifzadeh, Roghayeh Khalseh, Gullam Reza Barbari, Mohammad Abdollahi
BACKGROUND: The evolution of the 'Green' movement in western society has changed attitudes in the general population who now perceive natural compounds as being inherently harmless and more desirable than artificial chemical products. OBJECTIVE: Considering the growing interest towards introducing naturally emerged medicines, the purpose of this review was to overview the ongoing research into prevention and treatment of multiple sclerosis (MS) lesions. METHOD: This review was carried out by searching bibliographic databases such as PubMed and Scopus for studies reported between 1th January 2008 to 30rd January 2016 on MS patients or animal models of MS, investigating the beneficial effects of natural compounds in MS treatment...
November 8, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27659729/chronic-infusion-of-epigallocatechin-3-o-gallate-into-the-hypothalamic-paraventricular-nucleus-attenuates-hypertension-and-sympathoexcitation-by-restoring-neurotransmitters-and-cytokines
#4
Qiu-Yue Yi, Hong-Bao Li, Jie Qi, Xiao-Jing Yu, Chan-Juan Huo, Xiang Li, Juan Bai, Hong-Li Gao, Bo Kou, Kai-Li Liu, Dong-Dong Zhang, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Xiao-Lian Shi, Yu-Ming Kang
Reactive oxygen species (ROS) in the brain are involved in the pathogenesis of hypertension. Epigallocatechin-3-O-gallate (EGCG), one of the active compounds in green tea, has anti-oxidant, anti-inflammatory and vascular protective properties. This study was designed to determine whether chronic infusion of EGCG into the hypothalamic paraventricular nucleus (PVN) attenuates ROS and sympathetic activity and delays the progression of hypertension by up-regulating anti-inflammatory cytokines, reducing pro-inflammatory cytokines (PICs) and decreasing nuclear factor-kappa B (NF-κB) activity, as well as restoring the neurotransmitters balance in the PVN of spontaneously hypertensive rats (SHR)...
September 19, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27639810/potential-for-brain-accessibility-and-analysis-of-stability-of-selected-flavonoids-in-relation-to-neuroprotection-in-vitro
#5
Lea Pogačnik, Katja Pirc, Inês Palmela, Mihaela Skrt, Kim S Kwang, Dora Brites, Maria Alexandra Brito, Nataša Poklar Ulrih, Rui F M Silva
Natural food sources constitute a promising source of new compounds with neuroprotective properties, once they have the ability to reach the brain. Our aim was to evaluate the brain accessibility of quercetin, epigallocatechin gallate (EGCG) and cyanidin-3-glucoside (C3G) in relation to their neuroprotective capability. Primary cortical neuron cultures were exposed to oxidative insult in the absence and presence of the selected compounds, and neuroprotection was assessed through evaluation of apoptotic-like and necrotic-like cell death...
September 14, 2016: Brain Research
https://www.readbyqxmd.com/read/27457036/short-and-long-term-effects-of-neonatal-pharmacotherapy-with-epigallocatechin-3-gallate-on-hippocampal-development-in-the-ts65dn-mouse-model-of-down-syndrome
#6
Fiorenza Stagni, Andrea Giacomini, Marco Emili, Stefania Trazzi, Sandra Guidi, Martina Sassi, Elisabetta Ciani, Roberto Rimondini, Renata Bartesaghi
Cognitive disability is an unavoidable feature of Down syndrome (DS), a genetic disorder due to the triplication of human chromosome 21. DS is associated with alterations of neurogenesis, neuron maturation and connectivity that are already present at prenatal life stages. Recent evidence shows that pharmacotherapies can have a large impact on the trisomic brain provided that they are administered perinatally. Epigallocatechin-3-gallate (EGCG), the major polyphenol of green tea, performs many actions in the brain, including inhibition of DYRK1A, a kinase that is over-expressed in the DS brain and contributes to the DS phenotype...
October 1, 2016: Neuroscience
https://www.readbyqxmd.com/read/27400086/the-antioxidant-effect-of-green-tea-mega-egcg-against-electromagnetic-radiation-induced-oxidative-stress-in-the-hippocampus-and-striatum-of-rats
#7
Nawal A Ahmed, Nasr M Radwan, Heba S Aboul Ezz, Noha A Salama
Electromagnetic radiation (EMR) of cellular phones may affect biological systems by increasing free radicals and changing the antioxidant defense systems of tissues, eventually leading to oxidative stress. Green tea has recently attracted significant attention due to its health benefits in a variety of disorders, ranging from cancer to weight loss. Thus, the aim of the present study was to investigate the effect of EMR (frequency 900 MHz modulated at 217 Hz, power density 0.02 mW/cm(2), SAR 1.245 W/kg) on different oxidative stress parameters in the hippocampus and striatum of adult rats...
July 11, 2016: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/27268025/potential-neuroprotective-properties-of-epigallocatechin-3-gallate-egcg
#8
REVIEW
Neha Atulkumar Singh, Abul Kalam Azad Mandal, Zaved Ahmed Khan
Neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) enforce an overwhelming social and economic burden on society. They are primarily characterized through the accumulation of modified proteins, which further trigger biological responses such as inflammation, oxidative stress, excitotoxicity and modulation of signalling pathways. In a hope for cure, these diseases have been studied extensively over the last decade to successfully develop symptom-oriented therapies. However, so far no definite cure has been found...
June 7, 2016: Nutrition Journal
https://www.readbyqxmd.com/read/27080069/neurorestorative-effects-of-epigallocatechin-3-gallate-on-cognitive-function-in-a-chronic-cerebral-hypoperfusion-rat-model
#9
Jae-Young Han, Jung-Kook Kim, Jae-Hong Kim, Bong-Seok Oh, Wan-Ju Cho, Young Do Jung, Sam-Gyu Lee
PURPOSE: This study investigated whether (-)-epigallocatechin-3-gallate (EGCG) can enhance cognition by a neurorestorative effect in a rat model of bilateral common carotid artery occlusion (BCCAO). METHODS: Forty-eight male, 8-week-old Sprague-Dawley rats were randomly allocated to four groups 6 weeks after BCCAO or sham operation: EGCG-single intravenous injection (25 mg/kg/day; SIV group), EGCG-multiple intraperitoneal injection (50 mg/kg/day for 5 days; MIP group), untreated BCCAO group (untreated group), and sham-operated group (sham group)...
April 11, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27038929/-epigallocatechin-gallate-inhibits-asymmetric-dimethylarginine-induced-injury-in-human-brain-microvascular-endothelial-cells
#10
Jia Li, Zhiming Zhang, Lianjie Lv, Haibo Qiao, Xiuju Chen, Changlin Zou
(-)-Epigallocatechin gallate (EGCG) is the main polyphenol component of green tea (leaves of the Camellia sinensis plant). EGCG has been reported to protect human brain microvascular endothelial cells (HBMECs) against injury in several models. However, the exact mechanism is still unclear. In the current study we found that EGCG protected against asymmetric dimethylarginine (ADMA)-induced HBMEC injury, and inhibited ADMA-induced reactive oxygen species production and malondialdehyde expression. At the same time, we found that pretreatment with EGCG attenuated the upregulation of Bax and the downregulation of Bcl-2, thus confirming the cellular protective properties of EGCG against ADMA-induced apoptosis...
August 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27030967/egcg-inhibited-lipofuscin-formation-based-on-intercepting-amyloidogenic-%C3%AE-sheet-rich-structure-conversion
#11
Shuxian Cai, Heng Yang, Kewu Zeng, Jing Zhang, Ni Zhong, Yingzi Wang, Jing Ye, Pengfei Tu, Zhonghua Liu
BACKGROUND: Lipofuscin (LF) is formed during lipid peroxidation and sugar glycosylation by carbonyl-amino crosslinks with biomacrolecules, and accumulates slowly within postmitotic cells. The environmental pollution, modern dietary culture and lifestyle changes have been found to be the major sources of reactive carbonyl compounds in vivo. Irreversible carbonyl-amino crosslinks induced by carbonyl stress are essentially toxiferous for aging-related functional losses in modern society...
2016: PloS One
https://www.readbyqxmd.com/read/27005305/egcg-stabilizes-growth-cone-filopodia-and-impairs-retinal-ganglion-cell-axon-guidance
#12
Karen Atkinson-Leadbeater, Carrie L Hehr, Jill Johnston, Gabriel Bertolesi, Sarah McFarlane
BACKGROUND: Antioxidants such as the green tea polyphenol epigallocatechin gallate (EGCG) are neuroprotective under many conditions in mature nervous systems; however, their impact has rarely been explored in developing nervous systems, in which a critical step is the formation of connections between neurons. Axons emerge from newly formed neurons and are led by a dynamic structure found at their tip called a growth cone. Here we explore the impact of EGCG on the development of retinal ganglion cell (RGC) axons, which connect the eye to the brain...
June 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/26964795/the-polyphenols-resveratrol-and-epigallocatechin-3-gallate-restore-the-severe-impairment-of-mitochondria-in-hippocampal-progenitor-cells-from-a-down-syndrome-mouse-model
#13
Daniela Valenti, Lidia de Bari, Domenico de Rasmo, Anna Signorile, Alexandra Henrion-Caude, Andrea Contestabile, Rosa Anna Vacca
Mitochondrial dysfunctions critically impair nervous system development and are potentially involved in the pathogenesis of various neurodevelopmental disorders, including Down syndrome (DS), the most common genetic cause of intellectual disability. Previous studies from our group demonstrated impaired mitochondrial activity in peripheral cells from DS subjects and the efficacy of epigallocatechin-3-gallate (EGCG) - a natural polyphenol major component of green tea - to counteract the mitochondrial energy deficit...
June 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26944334/nitric-oxide-pathway-activity-modulation-alters-the-protective-effects-of-epigallocatechin-3-gallate-on-reserpine-induced-impairment-in-rats
#14
Cheng-Neng Chen, Kuo-Chi Chang, Rui-Feng Lin, Mao-Hsien Wang, Ruoh-Lan Shih, Hsiang-Chien Tseng, Hung-Sheng Soung, Cheng-Chia Tsai
Reserpine (RES) has been reported to increase the brain's neural oxidative stress and cause cognitive dysfunction. Having powerful antioxidative properties, green tea catechins, especially (-)epigallocatechin-3-gallate (EGCG), are able to protect against many oxidative injuries. In this study, we examined the protecting properties of EGCG on RES-induced impairment of short-term memory in three-month-old male Wistar rats. RES (1mg/kg i.p.) induced memory impairment (p<0.001) as evaluated by the social recognition task...
May 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26851971/epigallocatechin-gallate-extends-the-therapeutic-window-of-recombinant-tissue-plasminogen-activator-treatment-in-ischemic-rats
#15
Yi-Ping You
BACKGROUND: Ischemic stroke is the leading cause of death and disability worldwide. To date, recombinant tissue plasminogen activator (rt-PA) remains the only safe and effective pharmaceutical treatment for brain ischemia, but delayed rt-PA administration leads to hyperperfusion, which severely limits its clinical efficacy. METHODS: In this study, we investigated the effect of epigallocatechin gallate (EGCG) in extending the therapeutic window of rt-PA using a rat middle cerebral artery occlusion (MCAO) model...
April 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/26807022/epigallocatechin-3-gallate-rescues-lps-impaired-adult-hippocampal-neurogenesis-through-suppressing-the-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-in-mice
#16
Kyung-Joo Seong, Hyun-Gwan Lee, Min Suk Kook, Hyun-Mi Ko, Ji-Yeon Jung, Won-Jae Kim
Adult hippocampal dentate granule neurons are generated from neural stem cells (NSCs) in the mammalian brain, and the fate specification of adult NSCs is precisely controlled by the local niches and environment, such as the subventricular zone (SVZ), dentate gyrus (DG), and Toll-like receptors (TLRs). Epigallocatechin-3-gallate (EGCG) is the main polyphenolic flavonoid in green tea that has neuroprotective activities, but there is no clear understanding of the role of EGCG in adult neurogenesis in the DG after neuroinflammation...
January 2016: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/26775960/metal-chelation-radical-scavenging-and-inhibition-of-a%C3%AE-%C3%A2-%C3%A2-fibrillation-by-food-constituents-in-relation-to-alzheimer-s-disease
#17
Stephen Chan, Srinivas Kantham, Venkatesan M Rao, Manoj Kumar Palanivelu, Hoang L Pham, P Nicholas Shaw, Ross P McGeary, Benjamin P Ross
Various food constituents have been proposed as disease-modifying agents for Alzheimer's disease (AD), due to epidemiological evidence of their beneficial effects, and for their ability to ameliorate factors linked to AD pathogenesis, namely by: chelating iron, copper and zinc; scavenging reactive oxygen species; and suppressing the fibrillation of amyloid-beta peptide (Aβ). In this study, nine different food constituents (l-ascorbic acid, caffeic acid, caffeine, curcumin, (-)-epigallocatechin gallate (EGCG), gallic acid, propyl gallate, resveratrol, and α-tocopherol) were investigated for their effects on the above factors, using metal chelation assays, antioxidant assays, and assays of Aβ42 fibrillation...
May 15, 2016: Food Chemistry
https://www.readbyqxmd.com/read/26770869/egcg-protects-against-6-ohda-induced-neurotoxicity-in-a-cell-culture-model
#18
Dan Chen, Anumantha G Kanthasamy, Manju B Reddy
Background. Parkinson's disease (PD) is a progressive neurodegenerative disease that causes severe brain dopamine depletion. Disruption of iron metabolism may be involved in the PD progression. Objective. To test the protective effect of (-)-epigallocatechin-3-gallate (EGCG) against 6-hydroxydopamine- (6-OHDA-) induced neurotoxicity by regulating iron metabolism in N27 cells. Methods. Protection by EGCG in N27 cells was assessed by SYTOX green assay, MTT, and caspase-3 activity. Iron regulatory gene and protein expression were measured by RT-PCR and Western blotting...
2015: Parkinson's Disease
https://www.readbyqxmd.com/read/26761622/effects-of-exercise-and-dietary-epigallocatechin-gallate-and-%C3%AE-alanine-on-skeletal-muscle-in-aged-mice
#19
Brandt D Pence, Trisha E Gibbons, Tushar K Bhattacharya, Houston Mach, Jessica M Ossyra, Geraldine Petr, Stephen A Martin, Lin Wang, Stanislav S Rubakhin, Jonathan V Sweedler, Robert H McCusker, Keith W Kelley, Justin S Rhodes, Rodney W Johnson, Jeffrey A Woods
Aging leads to sarcopenia and loss of physical function. We examined whether voluntary wheel running, when combined with dietary supplementation with (-)-epigallocatechin-3-gallate (EGCG) and β-alanine (β-ALA), could improve muscle function and alter gene expression in the gastrocnemius of aged mice. Seventeen-month-old BALB/cByJ mice were given access to a running wheel or remained sedentary for 41 days while receiving either AIN-93M (standard feed) or AIN-93M containing 1.5 mg·kg(-1) EGCG and 3.43 mg·kg(-1) β-ALA...
February 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/26643169/epigallocatechin-gallate-attenuates-amyloid-%C3%AE-induced-inflammation-and-neurotoxicity-in-eoc-13-31-microglia
#20
James Cheng-Chung Wei, Hsiu-Chen Huang, Wei-Jen Chen, Chien-Ning Huang, Chiung-Huei Peng, Chih-Li Lin
Microglia are the primary immune cells that contribute to neuroinflammation by releasing various proinflammatory cytokines and neurotoxins in the brain. Microglia-mediated neuroinflammation is one of the key characteristics of Alzheimer's disease (AD). Therefore, inhibitory reagents that prevent microglial activation may be used as potential therapeutic agents for treating AD. Recently, many studies have been performed to determine the bioactivities of green tea polyphenol epigallocatechin-3-gallate (EGCG), an efficient antioxidant that prevents neuroinflammation...
January 5, 2016: European Journal of Pharmacology
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