Karema Abu-Elfotuh, Amina M A Tolba, Furqan H Hussein, Ahmed M E Hamdan, Mohamed A Rabeh, Saad A Alshahri, Azza A Ali, Sarah M Mosaad, Nihal A Mahmoud, Magdy Y Elsaeed, Ranya M Abdelglil, Rehab R El-Awady, Eman Reda M Galal, Mona M Kamal, Ahmed M M Elsisi, Alshaymaa Darwish, Ayah M H Gowifel, Yasmen F Mahran
Alzheimer's disease (AD) is a devastating illness with limited therapeutic interventions. The aim of this study is to investigate the pathophysiological mechanisms underlying AD and explore the potential neuroprotective effects of cocoa, either alone or in combination with other nutraceuticals, in an animal model of aluminum-induced AD. Rats were divided into nine groups: control, aluminum chloride (AlCl3 ) alone, AlCl3 with cocoa alone, AlCl3 with vinpocetine (VIN), AlCl3 with epigallocatechin-3-gallate (EGCG), AlCl3 with coenzyme Q10 (CoQ10), AlCl3 with wheatgrass (WG), AlCl3 with vitamin (Vit) B complex, and AlCl3 with a combination of Vit C, Vit E, and selenium (Se)...
July 31, 2023: Pharmaceutics