keyword
https://read.qxmd.com/read/37447256/associations-between-ileal-juice-bile-acids-and-colorectal-advanced-adenoma
#21
JOURNAL ARTICLE
Hung N Luu, Chi Thi-Du Tran, Renwei Wang, Mai Vu-Tuyet Nguyen, Mo Thi Tran, Thuy Thi-Van Tuong, Quang Hong Tran, Linh Cu Le, Huong Thi-Thu Pham, Hien Huy Vu, Nam Chi Bui, Hien Thi-Thu Ha, Dung Tuan Trinh, Claire E Thomas, Jennifer Adams-Haduch, Liudmilla Velikokhatnaya, Robert E Schoen, Guoxiang Xie, Wei Jia, Paolo Boffetta, Jose C Clemente, Jian-Min Yuan
BACKGROUND: There is an urgent need to identify biomarkers for advanced adenoma, an important precursor of colorectal cancer (CRC). We aimed to determine alterations in ileal juice bile acids associated with colorectal advanced adenoma. METHODS: We quantified a comprehensive panel of primary and secondary bile acids and their conjugates using an ultraperformance liquid chromatography triple-quadrupole mass spectrometric assay in ileal juice collected at colonoscopy from 46 study subjects (i...
June 28, 2023: Nutrients
https://read.qxmd.com/read/37434552/serum-metabolomic-analysis-revealed-potential-metabolite-biomarkers-for-diabetes-mellitus-with-coronary-heart-disease
#22
JOURNAL ARTICLE
Zhenning Jin, Wei Hu, Yan Yang
Diabetes, including its predominant form, type 2 diabetes mellitus (T2DM), has a distinctive correlation with coronary heart disease (CHD). Patients with diabetes have shown statistically higher potential risk of developing CHD complications than those without diabetes. In this study, we have conducted a metabolomic analysis of serum samples from healthy controls as well as patients with T2DM or both T2DM and CHD (CHD-T2DM). Statistical analysis of the metabolomic data revealed 611 and 420 significantly altered metabolic signatures in T2DM and CHD-T2DM patients, respectively, when compared to the healthy controls...
July 20, 2023: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/37426007/comprehensive-analysis-of-the-microbiome-and-metabolome-in-pus-from-pyogenic-liver-abscess-patients-with-and-without-diabetes-mellitus
#23
JOURNAL ARTICLE
Yawen Guo, Hairui Wang, Zhaoyu Liu, Zhihui Chang
INTRODUCTION: Pyogenic liver abscess (PLA) patients combined with diabetes mellitus (DM) tend to have more severe clinical manifestations than without DM. The mechanism responsible for this phenomenon is not entirely clear. The current study therefore aimed to comprehensively analyze the microbiome composition and metabolome in pus from PLA patients with and without DM, to determine the potential reasons for these differences. METHODS: Clinical data from 290 PLA patients were collected retrospectively...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/37383587/-lomatogonium-rotatum-extract-alleviates-diabetes-mellitus-induced-by-a-high-fat-high-sugar-diet-and-streptozotocin-in-rats
#24
JOURNAL ARTICLE
Li-Li Dai, Sung-Bo Cho, Hui-Fang Li, Li-Sha A, Xiao-Ping Ji, Sirigunqiqige Pan, Ming-Lan Bao, Laxinamujila Bai, Gen-Na Ba, Ming-Hai Fu
BACKGROUND: Lomatogonium rotatum (LR) is traditionally used in Mongolian folk medicine as a hypoglycemic agent, but its evidence-based pharmacological effects and me-chanisms of action have not been fully elucidated. AIM: To emphasize the hypoglycemic action mechanism of LR in a type 2 diabetic rat model and examine potential biomarkers to obtain mechanistic understanding regarding serum metabolite modifications. METHODS: A high-fat, high-sugar diet and streptozotocin injection-induced type 2 diabetic rat model was established...
June 15, 2023: World Journal of Diabetes
https://read.qxmd.com/read/37371622/metabolomic-investigation-of-blood-and-urinary-amino-acids-and-derivatives-in-patients-with-type-2-diabetes-mellitus-and-early-diabetic-kidney-disease
#25
JOURNAL ARTICLE
Maria Mogos, Carmen Socaciu, Andreea Iulia Socaciu, Adrian Vlad, Florica Gadalean, Flaviu Bob, Oana Milas, Octavian Marius Cretu, Anca Suteanu-Simulescu, Mihaela Glavan, Silvia Ienciu, Lavinia Balint, Dragos Catalin Jianu, Ligia Petrica
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease; however, few biomarkers of its early identification are available. The aim of the study was to assess new biomarkers in the early stages of DKD in type 2 diabetes mellitus (DM) patients. This cross-sectional pilot study performed an integrated metabolomic profiling of blood and urine in 90 patients with type 2 DM, classified into three subgroups according to albuminuria stage from P1 to P3 (30 normo-, 30 micro-, and 30 macroalbuminuric) and 20 healthy controls using high-performance liquid chromatography and mass spectrometry (UPLC-QTOF-ESI* MS)...
May 25, 2023: Biomedicines
https://read.qxmd.com/read/37231728/biological-effects-and-mechanisms-of-taurine-in-various-therapeutics
#26
JOURNAL ARTICLE
Shikha Sharma, Biswa Mohan Sahoo, Bimal Krishna Banik
More than two hundred years ago, taurine was first isolated from materials derived from animals. It is abundantly found in a wide range of mammalian and non-mammalian tissues and diverse environments. Taurine was discovered to be a by-product of the metabolism of sulfur only a little over a century and a half ago. Recently, there has been a renewed academic interest in researching and exploring various uses of the amino acid taurine, and recent research has indicated that it may be useful in the treatment of a variety of disorders, including seizures, high blood pressure, cardiac infarction, neurodegeneration, and diabetes...
May 25, 2023: Current Drug Discovery Technologies
https://read.qxmd.com/read/37196349/leucine-supplementation-ameliorates-early-life-programming-of-obesity-in-rats
#27
JOURNAL ARTICLE
Yuchen Sun, Bo Sun, Xuesong Han, Anshan Shan, Qingquan Ma
The advanced cessation of lactation elevates the risk of programmed obesity and obesity-related metabolic disorders in adulthood. The study used multi-omics analysis to investigate the mechanism behind this phenomenon and the effects of leucine supplementation on ameliorating programmed obesity development. Wistar/SD rat offspring were subjected to early weaning (EW) at d 17 (EWWIS and EWSD groups) or normal weaning at d 21 (CWIS and CSD groups). Half rats from the EWSD group were selected to create a new group with two-month leucine supplementation at d 150...
May 17, 2023: Diabetes
https://read.qxmd.com/read/37164267/the-associations-of-habitual-intake-of-sulfur-amino-acids-proteins-and-diet-quality-with-plasma-sulfur-amino-acid-concentrations-the-maastricht-study
#28
JOURNAL ARTICLE
Elena C Tore, Simone J P M Eussen, Nasser E Bastani, Pieter C Dagnelie, Amany K Elshorbagy, Pol Grootswagers, Viktor Kožich, Thomas Olsen, Helga Refsum, Kjetil Retterstøl, Coen D A Stehouwer, Emma T K Stolt, Kathrine J Vinknes, Marleen M J van Greevenbroek
BACKGROUND: Plasma sulfur amino acids (SAAs, i.e., methionine, total cysteine (tCys), total homocysteine (tHcy), cystathionine, total glutathione (tGSH) and taurine) are potential risk factors of obesity and cardiometabolic disorders. However, except for plasma tHcy, little is known about how dietary intake modifies the concentrations of plasma SAAs. OBJECTIVE: To investigate whether intake of SAAs and proteins or diet quality are associated with plasma SAAs. METHODS: Data from a cross-sectional subset of The Maastricht Study (n=1145, 50...
May 8, 2023: Journal of Nutrition
https://read.qxmd.com/read/37159251/effect-of-the-red-bull-energy-drink-on-perfusion-related-variables-in-women-undergoing-microsurgical-breast-reconstruction-protocol-and-analysis-plan-for-a-prospective-multicenter-randomized-controlled-trial
#29
JOURNAL ARTICLE
Nicole Edith Speck, Michal Michalak, Kathrin Dreier, Doris Babst, Alessia Marisa Lardi, Jian Farhadi
BACKGROUND: Maintaining a sufficiently high systolic blood pressure is essential for free flap perfusion after microsurgical breast reconstruction. Yet, many women undergoing these procedures have low postoperative systolic blood pressure. Intravenous volume administration or vasopressors may be needed to maintain systolic blood pressure above a predefined threshold. However, excessive volume administration may lead to volume overload and flap stasis, and the postoperative use of vasopressors may be limited depending on institutional standards...
May 9, 2023: JMIR Research Protocols
https://read.qxmd.com/read/37143475/eating-more-sardines-instead-of-fish-oil-supplementation-beyond-omega-3-polyunsaturated-fatty-acids-a-matrix-of-nutrients-with-cardiovascular-benefits
#30
REVIEW
Heitor O Santos, Theresa L May, Allain A Bueno
Omega-3 polyunsaturated fatty acids (n-3 PUFA) play a significant role in the prevention and management of cardiometabolic diseases associated with a mild chronic pro-inflammatory background, including type 2 diabetes, hypertension, hypertriglyceridaemia, and fatty liver disease. The effects of n-3 PUFA supplements specifically, remain controversial regarding reducing risks of cardiovascular events. n-3 PUFA supplements come at a cost for the consumer and can result in polypharmacy for patients on pharmacotherapy...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37110200/amino-acid-profiles-in-older-adults-with-frailty-secondary-analysis-from-metabofrail-and-biosphere-studies
#31
JOURNAL ARTICLE
Riccardo Calvani, Anna Picca, Leocadio Rodriguez-Mañas, Matteo Tosato, Hélio José Coelho-Júnior, Alessandra Biancolillo, Olga Laosa, Jacopo Gervasoni, Aniello Primiano, Lavinia Santucci, Ottavia Giampaoli, Isabelle Bourdel-Marchasson, Sophie C Regueme, Alan J Sinclair, Andrea Urbani, Francesco Landi, Giovanni Gambassi, Federico Marini, Emanuele Marzetti
An altered amino acid metabolism has been described in frail older adults which may contribute to muscle loss and functional decline associated with frailty. In the present investigation, we compared circulating amino acid profiles of older adults with physical frailty and sarcopenia (PF&S, n = 94), frail/pre-frail older adults with type 2 diabetes mellitus (F-T2DM, n = 66), and robust non-diabetic controls ( n = 40). Partial least squares discriminant analysis (PLS-DA) models were built to define the amino acid signatures associated with the different frailty phenotypes...
April 10, 2023: Metabolites
https://read.qxmd.com/read/37099672/dose-dependent-effects-of-taurine-against-testicular-damage-in-a-streptozotocin-induced-type-1-diabetes-mellitus-rat-model
#32
JOURNAL ARTICLE
Ahmed H ElBanna, Afaf S Osman, Amira Hossny, Hossny ElBanna, Fatma I Abo El-Ela
OBJECTIVES: Testicular dysfunction has been associated with chronic hyperglycemia in diabetes mellitus patients. We investigated taurine's possible mechanisms and protective effects against testicular damage using a rat model of streptozotocin-induced diabetes. METHODS: Wistar rats ( N = 56) were divided into seven equal groups. Untreated control rats received saline, and treated control rats received taurine 50 mg/kg orally. To induce diabetes, rats received a single dose of streptozotocin...
2023: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/37089301/novel-insights-into-the-mechanisms-of-hard-exudate-in-diabetic-retinopathy-findings-of-serum-lipidomic-and-metabolomics-profiling
#33
JOURNAL ARTICLE
Yinchen Shen, Hanying Wang, Junwei Fang, Kun Liu, Xun Xu
OBJECTIVE: Retinal hard exudates (HEs) result from lipoproteins leaking from capillaries into extracellular retinal space, and are related to decreased visual acuity in diabetic retinopathy (DR). This study aims to identify differential serum lipids and metabolites associated with HEs. MATERIALS AND METHODS: A cross-sectional study was conducted Jul 2017 ∼ Mar 2021. We assessed the amount of HEs using standard ETDRS photographs for comparison. HEs severity was rated as "no or questionable", "moderate" or "severe"...
April 2023: Heliyon
https://read.qxmd.com/read/37088809/exploring-the-mechanism-of-taohong-siwu-decoction-on-the-treatment-of-blood-deficiency-and-blood-stasis-syndrome-by-gut-microbiota-combined-with-metabolomics
#34
JOURNAL ARTICLE
Yao He, Huajuan Jiang, Kequn Du, Shengju Wang, Minmin Li, Chuan Ma, Fang Liu, Yan Dong, Chaomei Fu
BACKGROUND: Taohong Siwu Decoction (THSWD) is a prescription which included in the "List of Ancient Classic Prescriptions (First Batch)" issued by the National Administration of Traditional Chinese Medicine (TCM) and the National Medical Products Administration of the People's Republic of China. THSWD is effective and widely applied clinically for many diseases caused by blood deficiency and stasis syndrome in TCM, such as primary dysmenorrhea, menopausal syndrome, coronary heart disease, angina pectoris, and diabetes...
April 23, 2023: Chinese Medicine
https://read.qxmd.com/read/37033232/dynamic-changes-of-serum-taurine-and-the-association-with-gestational-diabetes-mellitus-a-nested-case-control-study
#35
JOURNAL ARTICLE
Jia Wang, Yuanyuan Wang, Wei Zheng, Xianxian Yuan, Cheng Liu, Ya Zhang, Wei Song, Xiaoxin Wang, Shengnan Liang, Xu Ma, Guanghui Li
OBJECTIVE: There is a lack of risk factors that can effectively identify gestational diabetes mellitus (GDM) in early pregnancy. It is unclear whether serum taurine in the first trimester and dynamic changes have different characteristics in GDM women. Whether these features are associated with the occurrence of GDM has not yet been elucidated. The main objective of this study was to observe the dynamic changes of serum taurine during pregnancy and investigate the relationship between serum taurine levels and GDM in the first and second trimesters...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37026518/functional-imaging-and-neurochemistry-identify-in-vivo-neuroprotection-mechanisms-counteracting-excitotoxicity-and-neurovascular-changes-in-the-hippocampus-and-visual-cortex-of-obese-and-type-2-diabetic-animal-models
#36
JOURNAL ARTICLE
Beatriz Caramelo, Tamaeh Monteiro-Alfredo, João Martins, José Sereno, João Castelhano, Bruno Manadas, Miguel Castelo-Branco, Paulo Matafome
Functional MRI (fMRI) with 1 H-MRS were combined on the hippocampus and visual cortex of animal models of obesity (high-fat diet, HFD) and type 2 diabetes (T2D) to identify the mechanisms involved and the temporal evolution of neurometabolic changes in these disorders that could serve as potentially reliable clinical biomarkers. HFD rats presented elevated levels of N-acetylaspartylglutamate (NAAG) (p=0.0365 vs standard diet, SD) and glutathione (GSH) (p=0.0494 vs SD) in the hippocampus. NAAG and GSH levels in this structure proved to be correlated (r = 0...
April 7, 2023: Journal of Neurochemistry
https://read.qxmd.com/read/37020298/exploring-the-aging-process-of-cognitively-healthy-adults-by-analyzing-cerebrospinal-fluid-metabolomics-using-liquid-chromatography-tandem-mass-spectrometry
#37
JOURNAL ARTICLE
Fu-Chao Liu, Mei-Ling Cheng, Chi-Jen Lo, Wen-Chuin Hsu, Gigin Lin, Huan-Tang Lin
BACKGROUND: During biological aging, significant metabolic dysregulation in the central nervous system may lead to cognitive decline and neurodegeneration. However, the metabolomics of the aging process in cerebrospinal fluid (CSF) has not been thoroughly explored. METHODS: In this cohort study of CSF metabolomics using liquid chromatography-mass spectrometry (LC-MS), fasting CSF samples collected from 92 cognitively unimpaired adults aged 20-87 years without obesity or diabetes were analyzed...
April 5, 2023: BMC Geriatrics
https://read.qxmd.com/read/37000613/microbiome-metabolomics-analysis-reveals-the-potential-effect-of-verbascoside-in-alleviating-cognitive-impairment-in-db-db-mice
#38
JOURNAL ARTICLE
Zheng Ran, Bowei Ju, Lin Cao, Qiang Hou, Limei Wen, Ruoyu Geng, Yucheng Liao, Junping Hu, Jianhua Yang
Cognitive impairment is the main central nervous system complication of diabetes, affecting the quality of life of patients. Herba Cistanche is a homologous plant widely used as a health food and therapeutic drug. Verbascoside, a signature component of Herba Cistanche , has anti-diabetic and neuroprotective effects. However, it is quickly metabolized by the gut microbiota, and the mechanism of its neuroprotection and improvement of learning and memory remains unclear. We investigated the effectiveness and potential mechanisms of verbascoside on cognitive dysfunction in db/db mice using a 16S rRNA microbiome and serum metabolomics approach...
March 31, 2023: Food & Function
https://read.qxmd.com/read/36941907/the-safety-and-efficacy-of-mesenchymal-stem-cells-in-the-treatment-of-type-2-diabetes-a-literature-review
#39
REVIEW
Aanchal Mathur, Sebastien Taurin, Sfoug Alshammary
INTRODUCTION: Type 2 diabetes (T2D) is the most common type of diabetes, affecting 6.28% of the population worldwide. Over the decades, multiple therapies and drugs have been developed to control T2D, but they are far from a long-term solution. Stem cells are promising as novel regenerative treatments, especially mesenchymal stem cells (MSCs), which are highly versatile in their regenerative and paracrine capabilities and characteristics. This makes them the most commonly used adult stem cells and ideal candidates to treat diabetes...
2023: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/36908447/metabolomic-profiles-in-night-shift-workers-a-cross-sectional-study-on-hospital-female-nurses
#40
JOURNAL ARTICLE
Elisa Borroni, Gianfranco Frigerio, Elisa Polledri, Rosa Mercadante, Cristina Maggioni, Luca Fedrizzi, Angela Cecilia Pesatori, Silvia Fustinoni, Michele Carugno
BACKGROUND AND AIM: Shift work, especially including night shifts, has been found associated with several diseases, including obesity, diabetes, cancers, and cardiovascular, mental, gastrointestinal and sleep disorders. Metabolomics (an omics-based methodology) may shed light on early biological alterations underlying these associations. We thus aimed to evaluate the effect of night shift work (NSW) on serum metabolites in a sample of hospital female nurses. METHODS: We recruited 46 nurses currently working in NSW in Milan (Italy), matched to 51 colleagues not employed in night shifts...
2023: Frontiers in Public Health
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