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Taurine AND Diabetes

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https://www.readbyqxmd.com/read/27857215/taurine-treatment-modulates-circadian-rhythms-in-mice-fed-a-high-fat-diet
#1
Ana Lucia C Figueroa, Hugo Figueiredo, Sandra A Rebuffat, Elaine Vieira, Ramon Gomis
Close ties have been made among certain nutrients, obesity, type 2 diabetes and circadian clocks. Among nutrients, taurine has been documented as being effective against obesity and type 2 diabetes. However, the impact of taurine on circadian clocks has not been elucidated. We investigated whether taurine can modulate or correct disturbances in daily rhythms caused by a high-fat diet in mice. Male C57BL/6 mice were divided in four groups: control (C), control + taurine (C+T), high-fat diet (HFD) and HFD + taurine (HFD+T)...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27825405/effects-of-chinese-medicinal-compound-jinmaitong-on-the-expression-of-nitrotyrosine-andnerve-growth-factor-in-the-dorsal-root-ganglia-of-diabetic-rats
#2
Ya-Nan Wu, Xiao-Chun Liang, Dan Yang, Ling Qu, Wei Liu, Yun-Zhou Gao
Objective To study the effects of Chinese medicinal compound Jinmaitong(JMT) on the expressions of nitrotyrosine (NT) and nerve growth factor (NGF) in dorsal root ganglia of diabetic rats. Methods Experimental rat diabetic models were established by the intraperitoneal injection of streptozotocin. Rat models were then randomly divided into four groups including normal control group (Con group),diabetes mellitus group (DM group),Jinmaitong group(JMT group)(treated with JMT similar to the fifteen-fold dose of adult recommended dosage),and taurine group(Tau group)(treated with Taurine similar to the fifteen-fold dose of adult recommended dosage),with 10 rats in each group...
October 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27816519/cognitive-decline-in-type-2-diabetic-db-db-mice-may-be-associated-with-brain-region-specific-metabolic-disorders
#3
Hong Zheng, Yongquan Zheng, Liangcai Zhao, Minjiang Chen, Guanghui Bai, Yongsheng Hu, Wenyi Hu, Zhihan Yan, Hongchang Gao
Type 2 diabetes has been associated with cognitive decline, but its metabolic mechanism remains unclear. In the present study, we attempted to investigate brain region-specific metabolic changes in db/db mice with cognitive decline and explore the potential metabolic mechanism linking type 2 diabetes and cognitive decline. We analyzed the metabolic changes in seven brain regions of two types of mice (wild-type mice and db/db mice with cognitive decline) using a (1)H NMR-based metabolomic approach. Then, a mixed-model analysis was used to evaluate the effects of mice type, brain region, and their interaction on metabolic changes...
November 3, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27813678/animal-proteins-as-important-contributors-to-a-healthy-human-diet
#4
Ibrahim Elmadfa, Alexa L Meyer
Adequate protein intake is critical for health and development. Generally, protein of animal origin is of higher quality for humans owing to its amino acid pattern and good digestibility. When administered in mixtures it can enhance the quality of plant proteins, but it is often scarce in low-income communities, especially in young children, the elderly, and pregnant and lactating women, who have increased requirements and in whom high-quality protein also stimulates bone growth and maintenance. Although high protein intake was associated with increased type 2 diabetes mellitus risk, milk and seafood are good sources of branched chain amino acids and taurine, which act beneficially on glucose metabolism and blood pressure...
October 28, 2016: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/27760051/long-noncoding-rna-tug1-regulates-mitochondrial-bioenergetics-in-diabetic-nephropathy
#5
Jianyin Long, Shawn S Badal, Zengchun Ye, Yin Wang, Bernard A Ayanga, Daniel L Galvan, Nathanael H Green, Benny H Chang, Paul A Overbeek, Farhad R Danesh
The regulatory roles of long noncoding RNAs (lncRNAs) in transcriptional coactivators are still largely unknown. Here, we have shown that the peroxisome proliferator-activated receptor γ (PPARγ) coactivator α (PGC-1α, encoded by Ppargc1a) is functionally regulated by the lncRNA taurine-upregulated gene 1 (Tug1). Further, we have described a role for Tug1 in the regulation of mitochondrial function in podocytes. Using a murine model of diabetic nephropathy (DN), we performed an unbiased RNA-sequencing (RNA-seq) analysis of kidney glomeruli and identified Tug1 as a differentially expressed lncRNA in the diabetic milieu...
November 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27760046/the-long-noncoding-rna-tug1-connects-metabolic-changes-with-kidney-disease-in-podocytes
#6
Szu Yuan Li, Katalin Susztak
An increasing amount of evidence suggests that metabolic alterations play a key role in chronic kidney disease (CKD) pathogenesis. In this issue of the JCI, Long et al. report that the long noncoding RNA (lncRNA) taurine-upregulated 1 (Tug1) contributes to CKD development. The authors show that Tug1 regulates mitochondrial function in podocytes by epigenetic targeting of expression of the transcription factor PPARγ coactivator 1α (PGC-1α, encoded by Ppargc1a). Transgenic overexpression of Tug1 specifically in podocytes ameliorated diabetes-induced CKD in mice...
November 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27714515/human-splanchnic-amino-acid-metabolism
#7
Evelien P J G Neis, S Sabrkhany, I Hundscheid, D Schellekens, K Lenaerts, S W Olde Damink, E E Blaak, C H C Dejong, Sander S Rensen
Plasma levels of several amino acids are correlated with metabolic dysregulation in obesity and type 2 diabetes. To increase our understanding of human amino-acid metabolism, we aimed to determine splanchnic interorgan amino-acid handling. Twenty patients planned to undergo a pylorus preserving pancreatico-duodenectomy were included in this study. Blood was sampled from the portal vein, hepatic vein, superior mesenteric vein, inferior mesenteric vein, splenic vein, renal vein, and the radial artery during surgery...
October 6, 2016: Amino Acids
https://www.readbyqxmd.com/read/27689719/bile-acid-profiles-in-diabetic-db-db-mice-and-their-wild-type-littermates
#8
Chang Chen, Bingying Hu, Tongzhi Wu, Yang Zhang, Yong Xu, Yulin Feng, Hongliang Jiang
This study aimed to obtain information on bile acid profiles in diabetic (db/db) mice and their wild type (wt) littermates for the understanding of pathogenesis and discovery of potential biomarkers of type 2 diabetes. Analytical methods based on protein precipitation or solid-phase extraction together with liquid chromatography-tandem mass spectrometry were developed for the determination of 25 bile acids in plasma, urine and feces samples collected from db/db and wt mice. GLP-1 concentration and hepatic genes related to bile acid synthesis were also investigated...
November 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27517894/anti-diabetic-activity-and-metabolic-changes-induced-by-andrographis-paniculata-plant-extract-in-obese-diabetic-rats
#9
Muhammad Tayyab Akhtar, Mohamad Syakir Bin Mohd Sarib, Intan Safinar Ismail, Faridah Abas, Amin Ismail, Nordin Hj Lajis, Khozirah Shaari
Andrographis paniculata is an annual herb and widely cultivated in Southeast Asian countries for its medicinal use. In recent investigations, A. paniculata was found to be effective against Type 1 diabetes mellitus (Type 1 DM). Here, we used a non-genetic out-bred Sprague-Dawley rat model to test the antidiabetic activity of A. paniculata against Type 2 diabetes mellitus (Type 2 DM). Proton Nuclear Magnetic Resonance (¹H-NMR) spectroscopy in combination with multivariate data analyses was used to evaluate the A...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27471162/the-effect-of-taurine-and-enriched-environment-on-behaviour-memory-and-hippocampus-of-diabetic-rats
#10
Francine Luciano Rahmeier, Lisiane Silveira Zavalhia, Lucas Silva Tortorelli, Fernanda Huf, Luiza Paul Géa, Rosalva Thereza Meurer, Aryadne Cardoso Machado, Rosane Gomez, Marilda da Cruz Fernandes
Diabetes mellitus (DM) has been studied recently as a major cause of cognitive deficits, memory and neurodegenerative damage. Taurine and enriched environment have stood out for presenting neuroprotective and stimulating effects that deserve further study. In this paper, we examined the effects of taurine and enriched environment in the context of diabetes, evaluating effects on behaviour, memory, death and cellular activity. Eighty-eight Wistar rats were divided into 2 groups (E=enriched environment; C=standard housing)...
September 6, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27466884/plasma-taurine-diabetes-genetic-predisposition-and-changes-of-insulin-sensitivity-in-response-to-weight-loss-diets
#11
Yan Zheng, Uta Ceglarek, Tao Huang, Tiange Wang, Yoriko Heianza, Wenjie Ma, George A Bray, Joachim Thiery, Frank M Sacks, Lu Qi
CONTEXT: Taurine metabolism disturbance is closely linked to obesity, insulin resistance, and diabetes. Previous evidence suggested that the preventative effects of taurine on diabetes might be through regulating the expression levels of diabetes-related genes. OBJECTIVE: We estimated whether blood taurine levels modified the overall genetic susceptibility to diabetes on improvement of insulin sensitivity in a randomized dietary trial. DESIGN AND SETTING: We genotyped 31 diabetes-associated variants to calculate a genetic risk score (GRS) and measured plasma taurine levels and glycemic traits among participants from the Preventing Overweight Using Novel Dietary Strategies (POUNDS Lost) trial...
October 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27289540/amino-acid-changes-during-transition-to-a-vegan-diet-supplemented-with-fish-in-healthy-humans
#12
Amany Elshorbagy, Fredrik Jernerén, Marianne Basta, Caroline Basta, Cheryl Turner, Maram Khaled, Helga Refsum
PURPOSE: To explore whether changes in dietary protein sources can lower plasma branched-chain amino acids (BCAAs), aromatic amino acids and sulfur amino acids (SAAs) that are often elevated in the obese, insulin-resistant state and in type 2 diabetes. METHODS: Thirty-six subjects (mean age 31 ± 2 years) underwent a voluntary abstinence from meat, poultry, eggs, and dairy products for 6 weeks, while enriching the diet with fish, in fulfillment of a religious fast...
June 11, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27089006/taurine-and-pioglitazone-attenuate-diabetes-induced-testicular-damage-by-abrogation-of-oxidative-stress-and-up-regulation-of-the-pituitary-gonadal-axis
#13
Sanaa M Abd El-Twab, Hanaa M Mohamed, Ayman M Mahmoud
Chronic hyperglycemia is associated with impairment of testicular function. The current study aimed to investigate the protective effects and the possible mechanisms of taurine and pioglitazone against diabetes-induced testicular dysfunction in rats. Diabetes was induced by streptozotocin injection. Both normal and diabetic rats received taurine (100 mg/kg) or pioglitazone (10 mg/kg) orally and daily for 6 weeks. Diabetic rats showed a significant (P < 0.001) increase in glycosylated hemoglobin, glucose, homeostasis model of insulin resistance, and pro-inflammatory cytokines...
June 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27017070/taurine-supplementation-improves-erectile-function-in-rats-with-streptozotocin-induced-type-1-diabetes-via-amelioration-of-penile-fibrosis-and-endothelial-dysfunction
#14
Yajun Ruan, Mingchao Li, Tao Wang, Jun Yang, Ke Rao, Shaogang Wang, Weiming Yang, Jihong Liu, Zhangqun Ye
INTRODUCTION: For patients with diabetes, erectile dysfunction (ED) is common and greatly affects quality of life. However, these patients often exhibit a poor response to first-line oral phosphodiesterase type 5 inhibitors. AIM: To investigate whether taurine, a sulfur-containing amino acid, affects diabetic ED (DED). METHODS: Type 1 diabetes mellitus was induced in male rats by using streptozotocin. After 12 weeks, an apomorphine test was conducted to confirm DED...
May 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/26990483/inhibition-of-endoplasmic-reticulum-stress-improves-coronary-artery-function-in-type-2-diabetic-mice
#15
Soo-Kyoung Choi, Mihwa Lim, Soo-In Yeon, Young-Ho Lee
What is the central question of this study? Endoplasmic reticulum (ER) stress has been reported to be involved in type 2 diabetes; however, the role of exacerbated ER stress in vascular dysfunction in type 2 diabetes remains unknown. What is the main finding and its importance? The main findings of this study are that ER stress is increased in the coronary arteries in type 2 diabetes, and inhibition of ER stress using taurine-conjugated ursodeoxycholic acid improves vascular function, which is associated with normalization of the myogenic response and endothelium-dependent relaxation...
June 1, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/26988565/protection-of-tauroursodeoxycholic-acid-on-high-glucose-induced-human-retinal-microvascular-endothelial-cells-dysfunction-and-streptozotocin-induced-diabetic-retinopathy-rats
#16
Chun-Fei Wang, Jia-Rui Yuan, Dong Qin, Jun-Fei Gu, Bing-Jie Zhao, Li Zhang, Di Zhao, Juan Chen, Xue-Feng Hou, Nan Yang, Wei-Quan Bu, Jing Wang, Chao Li, Gang Tian, Zi-Bo Dong, Liang Feng, Xiao-Bin Jia
ETHNOPHARMACOLOGICAL RELEVANCE: Tauroursodeoxycholic acid (TUDCA), one of the main ingredients from bear gall which hold "Clearing heat and detoxification, Removing liver fire for improving eyesight" functions, is formed by the conjugation of ursodeoxycholic acid (UDCA) with taurine. However, the limited information of TUDCA on protecting diabetic retinopathy (DR) has been known. The present study was conducted to evaluate the protection of TUDCA on high glucose-induced human retinal microvascular endothelial cells (HRMECs) dysfunction and streptozotocin (STZ)-induced diabetic retinopathy (DR) rats and the possible mechanism underlying was also explored...
June 5, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26955642/taurine-transporter-gene-expression-in-mononuclear-blood-cells-of-type-1-diabetes-patients
#17
Zaleida Napoli, Giuseppe Seghieri, Loria Bianchi, Roberto Anichini, Alessandra De Bellis, Ilaria Campesi, Ciriaco Carru, Stefano Occhioni, Angelo Zinellu, Flavia Franconi
Background. Taurine transporter gene expression (RNA-TauT) has a role in retinal cell function and is modulated in vitro and in vivo by hyperglycemia and/or oxidative stress. This study was aimed at testing whether RNA-TauT gene expression is modified in blood mononuclear peripheral cells (MPCs) of type 1 diabetic patients, is related to plasma markers of oxidative stress or endothelial dysfunction, or, finally, is related to presence of retinopathy. Methods. RNA-TauT was measured in MPCs by real-time PCR-analysis in 35 type 1 diabetic patients and in 33 age- and sex-matched controls, additionally measuring plasma and cell taurine and markers of oxidative stress and endothelial dysfunction...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/26918249/the-beneficial-effects-of-taurine-in-preventing-metabolic-syndrome
#18
REVIEW
Wen Chen, Junxia Guo, Yanzhen Zhang, Jing Zhang
Metabolic syndrome, a cluster of risk factors for diabetes and cardiovascular disease, has become a very serious public health concern. A number of studies have provided evidence that taurine has an efficient action against metabolic syndrome, which includes reducing triglycerides to prevent obesity, improving insulin resistance to regulate glucose metabolism, lowering cholesterol (especially decreasing VLDL + LDL cholesterol and increasing HDL cholesterol) to prevent diet-induced hypercholesterolemia, and regulating the renin-angiotensin-aldosterone system and the kallikrein-kinin system etc...
April 2016: Food & Function
https://www.readbyqxmd.com/read/26843082/effects-of-bariatric-surgery-on-serum-bile-acid-composition-and-conjugation-in-a-diabetic-rat-model
#19
Qunzheng Wu, Xiang Zhang, Mingwei Zhong, Haifeng Han, Shaozhuang Liu, Teng Liu, Meng Wei, Wei Guo, Haibin Xie, Sanyuan Hu, Guangyong Zhang
BACKGROUND: Serum bile acids (BAs) are elevated following bariatric surgery and have emerged as a potential glucose-lowering beneficial factor. The change of BA components and its underlying mechanisms may be of great significance during bariatric surgery. The aim of this study is to investigate the effects of different bariatric procedures on serum BA composition and explore the potential mechanisms using a diabetic rat model. METHODS: Duodenal-jejunal bypass (DJB), sleeve gastrectomy (SG), and sham operation were performed in diabetic rats induced by high-fat diet (HFD) and streptozotocin (STZ)...
October 2016: Obesity Surgery
https://www.readbyqxmd.com/read/26748055/tauroursodeoxycholic-acid-prevents-hearing-loss-and-hair-cell-death-in-cdh23-erl-erl-mice
#20
J Hu, M Xu, J Yuan, B Li, S Entenman, H Yu, Q Y Zheng
Sensorineural hearing loss has long been the subject of experimental and clinical research for many years. The recently identified novel mutation of the Cadherin23 (Cdh23) gene, Cdh23(erl/erl), was proven to be a mouse model of human autosomal recessive nonsyndromic deafness (DFNB12). Tauroursodeoxycholic acid (TUDCA), a taurine-conjugated bile acid, has been used in experimental research and clinical applications related to liver disease, diabetes, neurodegenerative diseases, and other diseases associated with apoptosis...
March 1, 2016: Neuroscience
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