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Taurine AND Diabetes

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https://www.readbyqxmd.com/read/29157816/effect-of-ipomoea-aquatica-ethanolic-extract-in-streptozotocin-stz-induced-diabetic-rats-via-1-h-nmr-based-metabolomics-approach
#1
Azliana Abu Bakar Sajak, Ahmed Mediani, Maulidiani, Nur Sumirah Mohd Dom, Chandradevan Machap, Muhajir Hamid, Amin Ismail, Alfi Khatib, Faridah Abas
BACKGROUND: Ipomoea aquatica (locally known as "kangkung") has previously been reported to have hypoglycemic activities on glucose level in diabetes patients. However, the effect of I. aquatica ethanolic extract on the metabolites in the body has remained unknown. PURPOSE: This study provides new insights on the changes of endogenous metabolites caused by I. aquatica ethanolic extract and improves the understanding on the therapeutic efficacy and mechanism of I...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29050977/prophylactic-role-of-taurine-and-its-derivatives-against-diabetes-mellitus-and-its-related-complications
#2
REVIEW
Poulami Sarkar, Priyanka Basak, Sumit Ghosh, Mousumi Kundu, Parames C Sil
Taurine is a conditionally essential amino acid present in the body in free form. Mammalian taurine is synthesized in the pancreas via the cysteine sulfinic acid pathway. Anti-oxidation and anti-inflammation are two main properties through which it exerts its therapeutic effects. Many studies have shown its excellent therapeutic potential against diabetes mellitus and related complications like diabetic neuropathy, retinopathy, nephropathy, hematological dysfunctions, reproductive dysfunctions, liver and pancreas related complications etc...
December 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28938442/angiotensin-ii-causes-%C3%AE-cell-dysfunction-through-an-er-stress-induced-proinflammatory-response
#3
Stanley M H Chan, Yeh-Siang Lau, Alyson A Miller, Jacqueline M Ku, Simon Potocnik, Ji-Ming Ye, Owen L Woodman, Terence P Herbert
The metabolic syndrome is associated with an increase in the activation of the renin angiotensin system, whose inhibition reduces the incidence of new-onset diabetes. Importantly, angiotensin II (AngII), independently of its vasoconstrictor action, causes β-cell inflammation and dysfunction, which may be an early step in the development of type 2 diabetes. The aim of this study was to determine how AngII causes β-cell dysfunction. Islets of Langerhans were isolated from C57BL/6J mice that had been infused with AngII in the presence or absence of taurine-conjugated ursodeoxycholic acid (TUDCA) and effects on endoplasmic reticulum (ER) stress, inflammation, and β-cell function determined...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28936709/taurine-counteracts-the-neurotoxic-effects-of-streptozotocin-induced-diabetes-in-rats
#4
Greice Caletti, Ana P Herrmann, Rianne Remus Pulcinelli, Luiza Steffens, Ana Moira Morás, Priscila Vianna, José Artur Bogo Chies, Dinara Jaqueline Moura, Helena Maria Tanhauser Barros, Rosane Gomez
Diabetes is a chronic metabolic disease associated with oxidative stress, damage to biomolecules such as DNA, and neuroinflammation. Taurine, a sulfur-containing amino acid widespread in the brain, has neuroprotective properties that might prevent tissue injury and DNA damage induced by chronic hyperglycemia. We evaluated the effects of chronic taurine treatment on oxidative stress parameters, DNA damage and inflammatory markers in the frontal cortex, and hippocampus of streptozotocin-induced diabetic rats...
September 21, 2017: Amino Acids
https://www.readbyqxmd.com/read/28915340/metabolic-profile-of-visual-cortex-in-diabetic-rats-measured-with-in-vivo-proton-mrs
#5
Shuang Li, Xinghua Wang, Junjie Yang, Hao Lei, Xuxia Wang, Yi Xiang
The purpose of the present study was to characterize the metabolic profile of the visual cortex in streptozotocin-induced Type 1 diabetic rats by means of in vivo proton MRS. Several metabolite concentration ratios in the visual cortex were calculated. In addition, postmortem histologic analyses for retinal ganglion cell (RGC) loss, optic nerve injury and visual cortex alterations were monitored. The results showed that diabetes induced several changes in visual cortex metabolites, such as reduced N-acetylaspartate, glutamate, γ-aminobutyric acid, taurine and choline-containing compound levels...
September 15, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28914810/an-nmr-based-metabolomic-approach-to-unravel-the-preventive-effect-of-water-soluble-extract-from-dendrobium-officinale-kimura-migo-on-streptozotocin-induced-diabetes-in-mice
#6
Hong Zheng, Linlin Pan, Pengtao Xu, Jianjun Zhu, Ruohan Wang, Wenzong Zhu, Yongsheng Hu, Hongchang Gao
Dendrobium officinale Kimura & Migo (D. officinale) is a precious herbal medicine. In this study, we investigated metabolic mechanism underlying the effect of D. officinale water extract (DOWE) on diabetes prevention in mice after streptozotocin (STZ) exposure using NMR-based metabolomics. Interestingly, we found a decrease in blood glucose and an increase in liver glycogen in mice pretreated with DOWE after STZ exposure. The DOWE pretreatment significantly increased citrate and glutamine in the serum as well as creatine, alanine, leucine, isoleucine, valine, glutamine, glutathione and taurine in the liver of STZ-treated mice...
September 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28751454/cysteamine-prevents-vascular-leakage-through-inhibiting-transglutaminase-in-diabetic-retina
#7
Yeon-Ju Lee, Se-Hui Jung, JongYun Hwang, Sohee Jeon, Eun-Taek Han, Won Sun Park, Seok-Ho Hong, Young-Myeong Kim, Kwon-Soo Ha
Cysteamine (an aminothiol), which is derived from coenzyme A degradation and metabolized into taurine, has beneficial effects against cystinosis and neurodegenerative diseases; however, its role in diabetic complications is unknown. Thus, we sought to determine the preventive effect of cysteamine against hyperglycemia-induced vascular leakage in the retinas of diabetic mice. Cysteamine and ethanolamine, the sulfhydryl group-free cysteamine analogue, inhibited vascular endothelial growth factor (VEGF)-induced stress fiber formation and vascular endothelial (VE)-cadherin disruption in endothelial cells, which play a critical role in modulating endothelial permeability...
October 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28685680/attenuation-of-diabetes-induced-cardiac-and-subcellular-defects-by-sulphur-containing-amino-acids
#8
Paramjit S Tappia, Adriana Adameova, Naranjan S Dhalla
BACKGROUND: Patients with diabetes mellitus have an increased risk of mortality due to cardiovascular complications. Supplementation with specific sulphur-containing amino acids is rapidly emerging as a possible therapeutic adjuvant for diabetes and associated cardiovascular complications. OBSERVATIONS: It is well known that oxidative stress plays an important role in the pathogenesis of diabetes-induced cardiovascular disease, which is invariably associated with abnormal blood lipid profile, insulin resistance and other symptoms of metabolic syndrome...
July 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28591636/n-acyl-taurines-and-acylcarnitines-cause-an-imbalance-in-insulin-synthesis-and-secretion-provoking-%C3%AE-cell-dysfunction-in-type-2-diabetes
#9
Michaela Aichler, Daniela Borgmann, Jan Krumsiek, Achim Buck, Patrick E MacDonald, Jocelyn E Manning Fox, James Lyon, Peter E Light, Susanne Keipert, Martin Jastroch, Annette Feuchtinger, Nikola S Mueller, Na Sun, Andrew Palmer, Theodore Alexandrov, Martin Hrabe de Angelis, Susanne Neschen, Matthias H Tschöp, Axel Walch
The processes contributing to β cell dysfunction in type 2 diabetes (T2D) are uncertain, largely because it is difficult to access β cells in their intact immediate environment. We examined the pathophysiology of β cells under T2D progression directly in pancreatic tissues. We used MALDI imaging of Langerhans islets (LHIs) within mouse tissues or from human tissues to generate in situ-omics data, which we supported with in vitro experiments. Molecular interaction networks provided information on functional pathways and molecules...
June 6, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28552532/taurine-decreased-uric-acid-levels-in-hyperuricemic-rats-and-alleviated-kidney-injury
#10
Ying Feng, Fang Sun, Yongchao Gao, Jiancheng Yang, Gaofeng Wu, Shumei Lin, Jianmin Hu
Hyperuricemia can lead to direct kidney damage. Taurine participates in several renal physiological processes and has been shown as a renoprotective agent. It has been reported that taurine could reduce uric acid levels in diabetic rats, but to date there was no research on the effects of taurine on hyperuricemic rats with kidney injury. In present study, hyperuricemic rat models were induced by intragastric administration of adenine and ethambutol hydrochloride for 10 days, and taurine (1% or 2%) were added in the drinking water 7 days in advance for consecutively 17 days...
July 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28335416/supplementation-with-phycocyanobilin-citrulline-taurine-and-supranutritional-doses-of-folic-acid-and-biotin-potential-for-preventing-or-slowing-the-progression-of-diabetic-complications
#11
Mark F McCarty
Oxidative stress, the resulting uncoupling of endothelial nitric oxide synthase (eNOS), and loss of nitric oxide (NO) bioactivity, are key mediators of the vascular and microvascular complications of diabetes. Much of this oxidative stress arises from up-regulated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity. Phycocyanobilin (PhyCB), the light-harvesting chromophore in edible cyanobacteria such as spirulina, is a biliverdin derivative that shares the ability of free bilirubin to inhibit certain isoforms of NADPH oxidase...
March 14, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28224697/antioxidant-treatment-ameliorates-diabetes-induced-dysfunction-of-the-vas-deferens-in-a-rat-model
#12
P Tsounapi, M Honda, F Dimitriadis, S Shimizu, T Shiomi, K Hikita, M Saito, S Tomita, N Sofikitis, A Takenaka
Diabetes mellitus (DM) affects the male ejaculatory function. This study was designed to evaluate the role of oxidative stress in the development of diabetes-induced dysfunction of vas deferens (VD) in the rat. DM was induced by streptozotocin in 40 male Wistar rats. Subsequently, the diabetic animals were divided into three groups: DM group, DM + Eda group and DM + Tau group. These groups were administered saline, edaravone and taurine, respectively, daily for 4 weeks. Another group of ten rats served as a control group...
February 22, 2017: Andrologia
https://www.readbyqxmd.com/read/28138003/the-effects-of-liraglutide-in-mice-with-diet-induced-obesity-studied-by-metabolomics
#13
Martina Bugáňová, Helena Pelantová, Martina Holubová, Blanka Šedivá, Lenka Maletínská, Blanka Železná, Jaroslav Kuneš, Petr Kačer, Marek Kuzma, Martin Haluzík
Liraglutide is the glucagon-like peptide-1 receptor agonist widely used for the treatment of type 2 diabetes mellitus. Recently, it has been demonstrated to decrease cardiovascular morbidity and mortality in patients with type 2 diabetes and high cardiovascular risk. Although the major modes of liraglutide action are well-known, its detailed action at the metabolic level has not been studied. To this end, we explored the effect of 2-week liraglutide treatment in C57BL/6 male mice with obesity and diabetes induced by 13 weeks of high-fat diet using NMR spectroscopy to capture the changes in urine metabolic profile induced by the therapy...
April 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28137588/long-noncoding-rna-tug1-alleviates-extracellular-matrix-accumulation-via-mediating-microrna-377-targeting-of-ppar%C3%AE-in-diabetic-nephropathy
#14
Li-Jun Duan, Min Ding, Li-Jun Hou, Yuan-Tao Cui, Chun-Jun Li, De-Min Yu
Long noncoding RNA taurine-upregulated gene 1 (lncRNA TUG1) has been reported to play a key role in the progression of diabetic nephropathy (DN). However, the role of lncRNA TUG1 in the regulation of diabetic nephropathy remains largely unknown. The aim of the present study is to identify the regulation of lncRNA TUG1 on extracellular matrix accumulation via mediating microRNA-377 targeting of PPARγ, and investigate the underlying mechanisms in progression of DN. Microarray was performed to screen differentially expressed miRNAs in db/db DN mice...
March 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28070703/nmr-based-metabolomics-reveals-brain-region-specific-metabolic-alterations-in-streptozotocin-induced-diabetic-rats-with-cognitive-dysfunction
#15
Hong Zheng, Qiuting Lin, Dan Wang, Pengtao Xu, Liangcai Zhao, Wenyi Hu, Guanghui Bai, Zhihan Yan, Hongchang Gao
Diabetes mellitus (DM) can result in cognitive dysfunction, but its potential metabolic mechanisms remain unclear. In the present study, we analyzed the metabolite profiling in eight different brain regions of the normal rats and the streptozotocin (STZ)-induced diabetic rats accompanied by cognitive dysfunction using a (1)H NMR-based metabolomic approach. A mixed linear model analysis was performed to assess the effects of DM, brain region and their interaction on metabolic changes. We found that different brain regions in rats displayed significant metabolic differences...
April 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27857215/taurine-treatment-modulates-circadian-rhythms-in-mice-fed-a-high-fat-diet
#16
Ana Lucia C Figueroa, Hugo Figueiredo, Sandra A Rebuffat, Elaine Vieira, Ramon Gomis
Close ties have been made among certain nutrients, obesity, type 2 diabetes and circadian clocks. Among nutrients, taurine has been documented as being effective against obesity and type 2 diabetes. However, the impact of taurine on circadian clocks has not been elucidated. We investigated whether taurine can modulate or correct disturbances in daily rhythms caused by a high-fat diet in mice. Male C57BL/6 mice were divided in four groups: control (C), control + taurine (C+T), high-fat diet (HFD) and HFD + taurine (HFD+T)...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27825405/effects-of-chinese-medicinal-compound-jinmaitong-on-the-expression-of-nitrotyrosine-andnerve-growth-factor-in-the-dorsal-root-ganglia-of-diabetic-rats
#17
Ya-Nan Wu, Xiao-Chun Liang, Dan Yang, Ling Qu, Wei Liu, Yun-Zhou Gao
Objective To study the effects of Chinese medicinal compound Jinmaitong(JMT) on the expressions of nitrotyrosine (NT) and nerve growth factor (NGF) in dorsal root ganglia of diabetic rats. Methods Experimental rat diabetic models were established by the intraperitoneal injection of streptozotocin. Rat models were then randomly divided into four groups including normal control group (Con group),diabetes mellitus group (DM group),Jinmaitong group(JMT group)(treated with JMT similar to the fifteen-fold dose of adult recommended dosage),and taurine group(Tau group)(treated with Taurine similar to the fifteen-fold dose of adult recommended dosage),with 10 rats in each group...
October 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27816519/cognitive-decline-in-type-2-diabetic-db-db-mice-may-be-associated-with-brain-region-specific-metabolic-disorders
#18
Hong Zheng, Yongquan Zheng, Liangcai Zhao, Minjiang Chen, Guanghui Bai, Yongsheng Hu, Wenyi Hu, Zhihan Yan, Hongchang Gao
Type 2 diabetes has been associated with cognitive decline, but its metabolic mechanism remains unclear. In the present study, we attempted to investigate brain region-specific metabolic changes in db/db mice with cognitive decline and explore the potential metabolic mechanism linking type 2 diabetes and cognitive decline. We analyzed the metabolic changes in seven brain regions of two types of mice (wild-type mice and db/db mice with cognitive decline) using a (1)H NMR-based metabolomic approach. Then, a mixed-model analysis was used to evaluate the effects of mice type, brain region, and their interaction on metabolic changes...
January 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27813678/animal-proteins-as-important-contributors-to-a-healthy-human-diet
#19
Ibrahim Elmadfa, Alexa L Meyer
Adequate protein intake is critical for health and development. Generally, protein of animal origin is of higher quality for humans owing to its amino acid pattern and good digestibility. When administered in mixtures it can enhance the quality of plant proteins, but its availability is often low in low-income communities, especially in young children, the elderly, and pregnant and lactating women, who have increased requirements and in whom high-quality protein also stimulates (bone) growth and maintenance...
February 8, 2017: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/27760051/long-noncoding-rna-tug1-regulates-mitochondrial-bioenergetics-in-diabetic-nephropathy
#20
Jianyin Long, Shawn S Badal, Zengchun Ye, Yin Wang, Bernard A Ayanga, Daniel L Galvan, Nathanael H Green, Benny H Chang, Paul A Overbeek, Farhad R Danesh
The regulatory roles of long noncoding RNAs (lncRNAs) in transcriptional coactivators are still largely unknown. Here, we have shown that the peroxisome proliferator-activated receptor γ (PPARγ) coactivator α (PGC-1α, encoded by Ppargc1a) is functionally regulated by the lncRNA taurine-upregulated gene 1 (Tug1). Further, we have described a role for Tug1 in the regulation of mitochondrial function in podocytes. Using a murine model of diabetic nephropathy (DN), we performed an unbiased RNA-sequencing (RNA-seq) analysis of kidney glomeruli and identified Tug1 as a differentially expressed lncRNA in the diabetic milieu...
November 1, 2016: Journal of Clinical Investigation
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