Borek Foldyna, Thomas Mayrhofer, Markella V Zanni, Asya Lyass, Radhika Barve, Julia Karady, Sara McCallum, Tricia H Burdo, Kathleen V Fitch, Kayla Paradis, Evelynne S Fulda, Marissa R Diggs, Gerald S Bloomfield, Carlos D Malvestutto, Carl J Fichtenbaum, Judith A Aberg, Judith S Currier, Heather J Ribaudo, Udo Hoffmann, Michael T Lu, Pamela S Douglas, Steven K Grinspoon
BACKGROUND: Pericoronary adipose tissue (PCAT) may influence plaque development through inflammatory mechanisms. We assessed PCAT density, as a measure of pericoronary inflammation, in relationship to coronary plaque among people with human immunodeficiency virus (HIV [PWH]) and to a matched control population. METHODS: In this baseline analysis of 727 participants of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) Mechanistic Substudy, we related computed tomography-derived PCAT density to presence and extent (Leaman score) of coronary artery disease (CAD), noncalcified plaque, coronary artery calcium (CAC), and vulnerable plaque features using multivariable logistic regression analyses...
December 15, 2023: Clinical Infectious Diseases