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https://www.readbyqxmd.com/read/28229066/a-case-of-influenza-a-h3n2-complicated-by-community-acquired-pneumonia-and-death-in-a-young-healthy-adult-during-the-2013-2014-season
#1
Lauren F Collins, Benjamin D Anderson, Gregory C Gray
With multiple available vaccines and antivirals, seasonal influenza A is typically a self-limited acutely debilitating illness in young healthy adults. Here, we illustrate unexpected morbidity and mortality in a relatively young and healthy patient seen at a large tertiary care academic medical center for seasonal influenza A (H3N2) complicated by community-acquired pneumonia, hypoxic respiratory failure, septic shock, and death.
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28228969/prevention-and-treatment-of-neonatal-nosocomial-infections
#2
REVIEW
Jayashree Ramasethu
Nosocomial or hospital acquired infections threaten the survival and neurodevelopmental outcomes of infants admitted to the neonatal intensive care unit, and increase cost of care. Premature infants are particularly vulnerable since they often undergo invasive procedures and are dependent on central catheters to deliver nutrition and on ventilators for respiratory support. Prevention of nosocomial infection is a critical patient safety imperative, and invariably requires a multidisciplinary approach. There are no short cuts...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/28227823/smartphone-based-swallowing-monitoring-and-feedback-device-for-mealtime-assistance-in-nursing-homes
#3
Naomi Kuramoto, Dushyantha Jayatilake, Kikue Hidaka, Kenji Suzuki, Naomi Kuramoto, Dushyantha Jayatilake, Kikue Hidaka, Kenji Suzuki, Kenji Suzuki, Kikue Hidaka, Dushyantha Jayatilake, Naomi Kuramoto
As many of the elderly are prone to dysphagia, preventing aspirations during mealtime assistance is a huge concern, especially for institutions operated with limited staff. Two of the main course of actions that are taken usually to prevent aspiration are the altering of bolus consistency and altering of the swallowing posture. To assist prevention of pneumonia, we have been developing a smartphone-based wearable technology that can evaluate swallowing ability in real-time. In this paper we will introduce modified version of Swallwoscope adding a posture detection system and a remote swallowing activity visualisation system to our previous work...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224517/-update-guidelines-for-the-treatment-and-prevention-of-adult-community-acquired-pneumonia-2016-what-is-new
#4
REVIEW
Santiago Ewig, Christian Giesa
No abstract text is available yet for this article.
February 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28223786/factors-involved-in-the-discontinuation-of-oral-intake-in-elderly-patients-with-recurrent-aspiration-pneumonia-a-multicenter-study
#5
Tsuneaki Kenzaka, Taro Takeshima, Koki Kosami, Ayako Kumabe, Yuki Ueda, Takeshi Takahashi, Yuya Yamamoto, Yurika Hayashi, Akihito Kitao, Masanobu Okayama
PURPOSE: To assess the factors involved in oral intake discontinuation in elderly patients with recurrent aspiration pneumonia. PATIENTS AND METHODS: This study included patients with pneumonia who were treated at Jichi Medical University Hospital between 2007 and 2013, at Toyooka Public Hospital between 2011 and 2013 and at Yuzawa Community Medical Center between 2010 and 2012. We consecutively enrolled patients with aspiration pneumonia. The primary study point was oral intake discontinuation after the initiation of oral intake during hospitalization in cases of recurrent aspiration...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28223459/evolution-and-epidemiology-of-multidrug-resistant-klebsiella-pneumoniae-in-the-united-kingdom-and-ireland
#6
Danesh Moradigaravand, Veronique Martin, Sharon J Peacock, Julian Parkhill
Klebsiella pneumoniae is a human commensal and opportunistic pathogen that has become a leading causative agent of hospital-based infections over the past few decades. The emergence and global expansion of hypervirulent and multidrug-resistant (MDR) clones of K. pneumoniae have been increasingly reported in community-acquired and nosocomial infections. Despite this, the population genomics and epidemiology of MDR K. pneumoniae at the national level are still poorly understood. To obtain insights into these, we analyzed a systematic large-scale collection of invasive MDR K...
February 21, 2017: MBio
https://www.readbyqxmd.com/read/28223386/surveillance-of-omadacycline-activity-tested-against-clinical-isolates-from-a-global-north-america-europe-latin-america-and-asia-western-pacific-collection-2010-2011
#7
Michael A Pfaller, Michael D Huband, Paul R Rhomberg, Robert K Flamm
Omadacycline is a broad spectrum aminomethylcycline in late-stage clinical development for acute bacterial skin and skin structure infections and community-acquired pneumonia as both an oral and intravenous, once-daily formulation. In this report omadacycline and comparators were tested against 69,246 non-duplicate bacterial isolates collected prospectively during 2010 and 2011 from medical centers in Asia-Pacific (11,397 isolates), Europe (23,490 isolates), Latin America (8,038 isolates) and North America (26,321 isolates)...
February 21, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28223319/development-and-testing-of-the-pediatric-respiratory-illness-measurement-system-primes-quality-indicators
#8
Rita Mangione-Smith, Carol P Roth, Maria T Britto, Alex Y Chen, Julie McGalliard, Thomas F Boat, John L Adams, Elizabeth A McGlynn
OBJECTIVES: To develop and test quality indicators for assessing care in pediatric hospital settings for common respiratory illnesses. PATIENTS: A sample of 2796 children discharged from the emergency department or inpatient setting at 1 of the 3 participating hospitals with a primary diagnosis of asthma, bronchiolitis, croup, or community-acquired pneumonia (CAP) between January 1, 2010, and December 31, 2011. SETTING: Three tertiary care children's hospitals in the United States...
February 21, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28221010/high-sensitivity-cardiac-troponin-t-predicts-mortality-after-hospitalization-for-community-acquired-pneumonia
#9
Stefan M T Vestjens, Simone M C Spoorenberg, Ger T Rijkers, Jan C Grutters, Jurriën M Ten Berg, Peter G Noordzij, Ewoudt M W Van de Garde, Willem Jan W Bos
BACKGROUND AND OBJECTIVE: Mortality after hospitalization with community-acquired pneumonia (CAP) is high, compared with age-matched controls. Available evidence suggests a strong link with cardiovascular disease. Our aim was to explore the prognostic value of high-sensitivity cardiac troponin T (cTnT) for mortality in patients hospitalized with CAP. METHODS: CTnT level on admission was measured (assay conducted in 2015) in 295 patients hospitalized with CAP who participated in a randomized placebo-controlled double-blind trial on adjunctive dexamethasone treatment...
February 21, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28219188/-change-of-prognosis-and-pathogens-in-adult-patients-with-severe-community-acquired-pneumonia-during-different-periods
#10
L Zhang, P Ning, F Rong, Z C Gao
Objective: To compare the change of prognosis and pathogens of adult patients with severe community-acquired pneumonia (CAP) requiring admission to Respiratory Intensive Care Unit (RICU) during different period, and estimate the risk factors of severe CAP. Methods: The clinical data of 186 patients with severe CAP admission to RICU was collected and assessed the trend in outcomes of these patients during three time periods: Period Ⅰ (January 1 2000 to October 31 2006), Period Ⅱ (November 1 2006 to December 31 2010), and Period Ⅲ (January 1 2011 to December 31 2015), analyzed the risk factors by Cox Proportional Hazards regression, and compared the pathogens detection...
February 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28218726/biomarkers-in-pediatric-community-acquired-pneumonia
#11
REVIEW
Nicola Principi, Susanna Esposito
Community-acquired pneumonia (CAP) is an infectious disease caused by bacteria, viruses, or a combination of these infectious agents. The severity of the clinical manifestations of CAP varies significantly. Consequently, both the differentiation of viral from bacterial CAP cases and the accurate assessment and prediction of disease severity are critical for effectively managing individuals with CAP. To solve questionable cases, several biomarkers indicating the etiology and severity of CAP have been studied...
February 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28211009/pneumococcal-predictive-proteins-selected-by-microbial-genomic-approach-are-serotype-cross-reactive-and-bind-to-host-extracellular-matrix-proteins
#12
Ana Paula Corrêa Argondizzo, Cláudio Marcos Rocha-de-Souza, Marta de Almeida Santiago, Ricardo Galler, Joice Neves Reis, Marco Alberto Medeiros
Streptococcus pneumoniae is a colonizer of the human nasopharynx, which accounts for most of the community-acquired pneumonia cases and can cause non-invasive and invasive diseases. Current available vaccines are serotype-specific and the use of recombinant proteins associated with virulence is an alternative to compose vaccines and to overcome these problems. In a previous work, we describe the identification of proteins in S. pneumoniae by reverse vaccinology and the genetic diversity of these proteins in clinical isolates...
February 17, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28209047/-utility-of-specific-serological-markers-in-patients-with-community-acquired-pneumonia-after-initial-treatment
#13
H Wang, J M Qu, J F Xu
No abstract text is available yet for this article.
February 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28206691/new-biomarkers-in-community-acquired-pneumonia-another-step-in-improving-outcome-prediction
#14
EDITORIAL
Paola Faverio, Oriol Sibila
No abstract text is available yet for this article.
February 16, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28205683/cardiovascular-complications-and-short-term-mortality-risk-in-community-acquired-pneumonia
#15
Francesco Violi, Roberto Cangemi, Marco Falcone, Gloria Taliani, Filippo Pieralli, Vieri Vannucchi, Carlo Nozzoli, Mario Venditti, Julio A Chirinos, Vicente F Corrales-Medina
No abstract text is available yet for this article.
February 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28202294/point-of-care-lung-ultrasound-in-children-with-community-acquired-pneumonia
#16
Hayri Levent Yilmaz, Ahmet Kağan Özkaya, Sinem Sarı Gökay, Özlem Tolu Kendir, Hande Şenol
OBJECTIVES: To present lung ultrasound findings in children assessed with suspected pneumonia in the emergency department and to show the benefit of lung ultrasound in diagnosing pneumonia in comparison with chest X-rays. METHODS: This observational prospective study was performed in the pediatric emergency department of a single center. Point of care lung ultrasound was performed on each child by an independent sonographer blinded to the patient's clinical and chest X-ray findings...
February 1, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28199385/mycoplasma-pneumoniae-cards-toxin-elicits-a-functional-ige-response-in-balb-c-mice
#17
Jorge L Medina, Edward G Brooks, Adriana Chaparro, Peter H Dube
Mycoplasma pneumoniae is strongly associated with new onset asthma and asthma exacerbations. Until recently, the molecular mechanisms utilized by M. pneumoniae to influence asthma symptoms were unknown. However, we recently reported that an ADP-ribosylating and vacuolating toxin called the Community Acquired Respiratory Distress Syndrome toxin, CARDS toxin, produced by M. pneumoniae was sufficient to promote allergic inflammation and asthma-like disease in mice. A mouse model of CARDS toxin exposure was used to evaluate total and CARDS-toxin specific serum IgE responses...
2017: PloS One
https://www.readbyqxmd.com/read/28199348/presentation-management-and-outcomes-of-sepsis-in-adults-and-children-admitted-to-a-rural-ugandan-hospital-a-prospective-observational-cohort-study
#18
Kristina E Rudd, Leonard K Tutaryebwa, T Eoin West
OBJECTIVES: Limited data are available on sepsis in low-resource settings, particularly outside of urban referral centers. We conducted a prospective observational single-center cohort study in May 2013 to assess the presentation, management and outcomes of adult and pediatric patients admitted with sepsis to a community hospital in rural Uganda. METHODS: We consecutively screened all patients admitted to medical wards who met sepsis criteria. We evaluated eligible patients within 24 hours of presentation and 24-48 hours after admission, and followed them until hospital discharge...
2017: PloS One
https://www.readbyqxmd.com/read/28198726/community-acquired-pneumonia-requiring-hospitalization-rational-decision-making-and-interpretation-of-guidelines
#19
Douwe F Postma, Cornelis H van Werkhoven, Jan Jelrik Oosterheert
PURPOSE OF REVIEW: This review focuses on the evidence base for guideline recommendations on the diagnosis, the optimal choice, timing and duration of empirical antibiotic therapy, and the use of microbiological tests for patients hospitalized with community-acquired pneumonia (CAP): issues for which guidelines are frequently used as a quick reference. Furthermore, we will discuss possibilities for future research in these topics. RECENT FINDINGS: Many national and international guideline recommendations, even on critical elements of CAP management, are based on low-to-moderate quality evidence...
February 13, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28196943/association-between-community-management-of-pneumonia-and-diarrhoea-in-high-burden-countries-and-the-decline-in-under-five-mortality-rates-an-ecological-analysis
#20
Cynthia Boschi-Pinto, Thandassery Ramachandran Dilip, Anthony Costello
OBJECTIVE: The objective of the paper is to explore if the adoption of national policies to use community-based health providers for the management of pneumonia and diarrhoea is associated with the decline in under-five mortality, including achievement of the Millennium Development Goal (MDG)4 target, in high-burden countries. SETTING: This country level analysis covers 75 high-burden low-income and middle-income countries which accounted for 98% of the 5.9 million global under-five deaths in 2015...
February 14, 2017: BMJ Open
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