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https://www.readbyqxmd.com/read/29027436/-protective-effect-of-earthworm-active-ingredients-against-endoplasmic-reticulum-stress-induced-acute-liver-injury-in-mice
#1
Ya-Fei Zhao, Yang Gao, Xin-Fang Wu, Jian-Gang Wang, Leng-Xin Duan
To study the protective effect of earthworm active ingredients(EWAs) against endoplasmic reticulum stress(ERS)-induced acute liver injury in mice. The model of liver injury was induced through intraperitoneal injection of 10%CCl4. Serum glutamic-pyruvic transaminase(ALT), glutamic-oxaloacetic transaminase(AST), superoxide dismutase(SOD) and glutathione peroxidase(GSH-PX) activity and malondialdehyde(MDA) concentration were detected by colorimetric method. Histological examination was performed through hematoxylin-eosin staining and light microscopy, and apoptosis was detected using terminal transferase dUTP nick end labeling...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28990224/evaluation-of-haematological-serum-biochemical-and-histopathological-parameters-of-growing-rabbits-fed-amaranthus-dubius
#2
E Molina, P González-Redondo, R Moreno-Rojas, K Montero-Quintero, N Chirinos-Quintero, A Sánchez-Urdaneta
Amaranthus dubius is an alternative source of fibre and protein for the feed formulation for growing rabbits, although its effects on their health status are yet unknown. Therefore, this study aimed to evaluate the effects of three dietary levels (0, 160 and 320 g/kg) of A. dubius on haematological, serum biochemical and histopathological parameters of fattening rabbits. One hundred and thirteen New Zealand White rabbits were fed ad libitum from weaning (35 days) to slaughter (87 days). The health status of the animals was monitored, and mortality was recorded...
October 8, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28974980/effects-of-hydroalcoholic-extract-of-rhus-coriaria-seed-on-glucose-and-insulin-related-biomarkers-lipid-profile-and-hepatic-enzymes-in-nicotinamide-streptozotocin-induced-type-ii-diabetic-male-mice
#3
Akram Ahangarpour, Hamid Heidari, Majid Salehizade Junghani, Reza Absari, Mehdi Khoogar, Ehsan Ghaedi
Type 2 diabetes often leads to dislipidemia and abnormal activity of hepatic enzymes. The purpose of this study was to evaluate the antidiabetic and hypolipidemic properties of Rhus coriaria (R. coriaria) seed extrac on nicotinamide-streptozotocin induced type 2 diabetic mice. In this experimental study, 56 male Naval Medical Research Institute mice (30-35 g) were randomly separated into seven groups: control, diabetic group, diabetic mice treated with glibenclamide (0.25 mg/kg, as standard antidiabetic drug) or R...
October 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28958693/amino-acid-profile-and-metabolic-syndrome-in-a-male-mediterranean-population-a-cross-sectional-study
#4
A Ntzouvani, T Nomikos, D Panagiotakos, E Fragopoulou, C Pitsavos, A McCann, P M Ueland, S Antonopoulou
BACKGROUND AND AIMS: The metabolic syndrome (MetS) refers to a cluster of clinically relevant factors that increases the risk of cardiovascular diseases and all-cause mortality. Circulating levels of several amino acids and metabolites related to one-carbon metabolism have been associated with cardiometabolic risk factors and MetS. We aimed to identify the amino acid profile that is significantly associated with MetS among an all male Mediterranean population. METHODS AND RESULTS: One hundred middle-aged men (54...
July 25, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28956808/poly-lactic-acid-blends-with-poly-trimethylene-carbonate-as-biodegradable-medical-adhesive-material
#5
Shuang Zhang, Hongli Li, Mingwei Yuan, Minglong Yuan, Haiyun Chen
A novel medical adhesive was prepared by blending poly(lactic acid) (PLA) with poly(trimethylene carbonate) (PTMC) in ethyl acetate, and the two materials were proven to be biodegradable and biocompatible. The medical adhesive was characterized by ¹H nuclear magnetic resonance (¹HNMR), gel permeation chromatography (GPC), scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The water vapor transmission rate (WVTR) of this material was measured to be 7.13 g·cm(-2)·24 h(-1). Its degree of comfortability was confirmed by the extensibility (E) and the permanent set (PS), which were approximately 7...
September 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28955961/kynurenine-aminotransferase-3-glutamine-transaminase-l-cysteine-conjugate-beta-lyase-2-is-a-major-glutamine-transaminase-in-the-mouse-kidney
#6
Cihan Yang, Lei Zhang, Qian Han, Chenghong Liao, Jianqiang Lan, Haizhen Ding, Hailong Zhou, Xiaoping Diao, Jianyong Li
BACKGROUND: Kynurenine aminotransferase 3 (KAT3) catalyzes the transamination of Kynurenine to kynurenic acid, and is identical to cysteine conjugate beta-lyase 2 (CCBL2) and glutamine transaminase L (GTL). GTL was previously purified from the rat liver and considered as a liver type glutamine transaminase. However, because of the substrate overlap and high sequence similarity of KAT3 and KAT1, it was difficult to assay the specific activity of each KAT and to study the enzyme localization in animals...
December 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28942523/overexpression-of-plastidic-maize-nadp-malate-dehydrogenase-zmnadp-mdh-in-arabidopsis-thaliana-confers-tolerance-to-salt-stress
#7
Deepika Kandoi, Sasmita Mohanty, Baishnab C Tripathy
The plastidic C4 Zea mays NADP-malate dehydrogenase (ZmNADP-MDH), responsible for catalysis of oxaloacetate to malate, was overexpressed in Arabidopsis thaliana to assess its impact on photosynthesis and tolerance to salinity stress. Different transgenic lines were produced having ~3-6-fold higher MDH protein abundance and NADP-MDH enzyme activity than vector control. The overexpressors had similar chlorophyll, carotenoid, and protein content as that of vector control. Their photosynthetic electron transport rates, carbon assimilation rate, and consequently fresh weight and dry weight were almost similar...
September 24, 2017: Protoplasma
https://www.readbyqxmd.com/read/28932214/succinyl-coa-mesaconate-coa-transferase-and-mesaconyl-coa-hydratase-enzymes-of-the-methylaspartate-cycle-in-haloarcula-hispanica
#8
Farshad Borjian, Ulrike Johnsen, Peter Schönheit, Ivan A Berg
Growth on acetate or other acetyl-CoA-generating substrates as a sole source of carbon requires an anaplerotic pathway for the conversion of acetyl-CoA into cellular building blocks. Haloarchaea (class Halobacteria) possess two different anaplerotic pathways, the classical glyoxylate cycle and the novel methylaspartate cycle. The methylaspartate cycle was discovered in Haloarcula spp. and operates in ∼40% of sequenced haloarchaea. In this cycle, condensation of one molecule of acetyl-CoA with oxaloacetate gives rise to citrate, which is further converted to 2-oxoglutarate and then to glutamate...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28928432/two-nad-linked-redox-shuttles-maintain-the-peroxisomal-redox-balance-in-saccharomyces-cerevisiae
#9
Nadal A Al-Saryi, Murtakab Y Al-Hejjaj, Carlo W T van Roermund, Georgia E Hulmes, Lakhan Ekal, Chantell Payton, Ronald J A Wanders, Ewald H Hettema
In Saccharomyces cerevisiae, peroxisomes are the sole site of fatty acid β-oxidation. During this process, NAD(+) is reduced to NADH. When cells are grown on oleate medium, peroxisomal NADH is reoxidised to NAD(+) by malate dehydrogenase (Mdh3p) and reduction equivalents are transferred to the cytosol by the malate/oxaloacetate shuttle. The ultimate step in lysine biosynthesis, the NAD(+)-dependent dehydrogenation of saccharopine to lysine, is another NAD(+)-dependent reaction performed inside peroxisomes...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28890689/integration-between-glycolysis-and-glutamate-glutamine-cycle-flux-may-explain-preferential-glycolytic-increase-during-brain-activation-requiring-glutamate
#10
REVIEW
Leif Hertz, Ye Chen
The 1988 observation by Fox et al. (1988) that brief intense brain activation increases glycolysis (pyruvate formation from glucose) much more than oxidative metabolism has been abundantly confirmed. Specifically glycolytic increase was unexpected because the amount of ATP it generates is much smaller than that formed by subsequent oxidative metabolism of pyruvate. The present article shows that preferential glycolysis can be explained by metabolic processes associated with activation of the glutamate-glutamine cycle...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/28887915/hepatoprotective-naphthalene-diglucoside-from-neanotis-wightiana-aerial-parts
#11
Niranjan Das, Atanas G Atanasov, Prashanta Kumar Deb, Andrei Mocan, Seyed Mohammad Nabavi, Ranjib Ghosh, Biswanath Dinda
BACKGROUND: Neanotis wightiana (Wall. ex Wight & Arn) W.H. Lewis has been used in traditional medicine in India for the treatment of liver disorders. In fact, this plant is frequently used by the local people of Tripura for the treatment of liver disorder problems. In previous study on this plant we have isolated a hepatoprotective saponin, neanoside A. PURPOSE: Evaluation of in vivo hepatoprotective effects of isolated compounds from N. wightiana aerial parts on serum hepatic-biomarkers in CCl4- induced hepatotoxicity in rats to validate the traditional use of the plant...
September 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28887308/uncovering-human-mettl12-as-a-mitochondrial-methyltransferase-that-modulates-citrate-synthase-activity-through-metabolite-sensitive-lysine-methylation
#12
Jędrzej Małecki, Magnus E Jakobsson, Angela Y Y Ho, Anders Moen, Arild Rustan, Pål Ø Falnes
Lysine methylation is an important and much-studied posttranslational modification of nuclear and cytosolic proteins, but is present also in mitochondria. However, the responsible mitochondrial lysine-specific methyltransferases (KMTs) remain largely elusive. Here, we investigated METTL12, a mitochondrial human S-adenosylmethionine (AdoMet)-dependent methyltransferase, and found it to methylate a single protein in mitochondrial extracts, identified as citrate synthase (CS). Using several in vitro and in vivo approaches, we demonstrated that METTL12 methylates CS on Lys-395, which is localized in the CS active site...
September 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28882954/antrodia-cinnamomea-reduces-carbon-tetrachloride-induced-hepatotoxicity-in-male-wister-rats
#13
Yung-Luen Shih, Ming-Fang Wu, Ching-Hsiao Lee, Ming-Yang Yeh, Jason Chou, Jia-You Liu, Hsu-Feng Lu, Yi-Ping Huang, Nien-Chieh Liao, Jing-Gung Chung
BACKGROUND/AIM: Antrodia cinnamomea is found with polysaccharides, lipids, vitamins, fibers and ash (minerals) and is well known in Taiwan as a traditional Chinese medicine. Its biological activities have been reported to have anti-inflammatory, anti-fatigue, anti-tumor and immunomodulatory effects, but its protective effects on liver function are still unclear. MATERIALS AND METHODS: We determined if Antrodia cinnamomea was hepatoprotective against carbon tetrachloride (CCl4) toxicity in Wistar rats...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28878861/genome-sequence-of-the-sulfur-oxidizing-bathymodiolus-thermophilus-gill-endosymbiont
#14
Ruby Ponnudurai, Lizbeth Sayavedra, Manuel Kleiner, Stefan E Heiden, Andrea Thürmer, Horst Felbeck, Rabea Schlüter, Stefan M Sievert, Rolf Daniel, Thomas Schweder, Stephanie Markert
Bathymodiolus thermophilus, a mytilid mussel inhabiting the deep-sea hydrothermal vents of the East Pacific Rise, lives in symbiosis with chemosynthetic Gammaproteobacteria within its gills. The intracellular symbiont population synthesizes nutrients for the bivalve host using the reduced sulfur compounds emanating from the vents as energy source. As the symbiont is uncultured, comprehensive and detailed insights into its metabolism and its interactions with the host can only be obtained from culture-independent approaches such as genomics and proteomics...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/28874460/citric-acid-metabolism-in-resistant-hypertension-underlying-mechanisms-and-metabolic-prediction-of-treatment-response
#15
Marta Martin-Lorenzo, Paula J Martinez, Montserrat Baldan-Martin, Gema Ruiz-Hurtado, Jose Carlos Prado, Julian Segura, Fernando de la Cuesta, Maria G Barderas, Fernando Vivanco, Luis Miguel Ruilope, Gloria Alvarez-Llamas
Resistant hypertension (RH) affects 9% to 12% of hypertensive adults. Prolonged exposure to suboptimal blood pressure control results in end-organ damage and cardiovascular risk. Spironolactone is the most effective drug for treatment, but not all patients respond and side effects are not negligible. Little is known on the mechanisms responsible for RH. We aimed to identify metabolic alterations in urine. In addition, a potential capacity of metabolites to predict response to spironolactone was investigated...
September 5, 2017: Hypertension
https://www.readbyqxmd.com/read/28861402/ixodes-scapularis-tick-cells-control-anaplasma-phagocytophilum-infection-by-increasing-the-synthesis-of-phosphoenolpyruvate-from-tyrosine
#16
Alejandro Cabezas-Cruz, Pedro J Espinosa, Dasiel A Obregón, Pilar Alberdi, José de la Fuente
The obligate intracellular pathogen, Anaplasma phagocytophilum, is the causative agent of life-threatening diseases in humans and animals. A. phagocytophilum is an emerging tick-borne pathogen in the United States, Europe, Africa and Asia, with increasing numbers of infected people and animals every year. It is increasingly recognized that intracellular pathogens modify host cell metabolic pathways to increase infection and transmission in both vertebrate and invertebrate hosts. Recent reports have shown that amino acids are central to the host-pathogen metabolic interaction...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28859156/longterm-storage-of-post-packaged-bread-by-controlling-spoilage-pathogens-using-lactobacillus-fermentum-c14-isolated-from-homemade-curd
#17
Soma Barman, Ranjan Ghosh, Shreya Sengupta, Narayan C Mandal
One potent lactic acid bacterial strain C14 with strong antifungal activity was isolated from homemade curd. Based on morphological as well as biochemical characters and 16S rDNA sequence homology the strain was identified as Lactobacillus fermentum. It displayed a wide antimicrobial spectrum against both Gram-positive and Gram-negative pathogenic bacteria, and also against number of food spoilage, plant and human pathogenic fungi. The cell free supernatant (CFS) of the strain C14 was also effective against the fungi tested...
2017: PloS One
https://www.readbyqxmd.com/read/28840658/experimental-design-and-metabolic-flux-analysis-tools-to-optimize-industrially-relevant-haemophilus-influenzae-type-b-growth-medium
#18
Mateus Ribeiro da Silva, Carla Andreia Freixo Portela, Silvia Maria Ferreira Albani, Paola Rizzo de Paiva, Martha Massako Tanizaki, Teresa Cristina Zangirolami
Haemophilus influenzae type b (Hib), a Gram-negative capsulated bacterium, is a causative agent of meningitis worldwide. The capsular polysaccharide, a high molecular mass polymer consisting of the repeated units of the polyribosyl-ribitol-phosphate, is considered the main virulence factor and it is used as an antigen to vaccines, conjugated to a carrier protein. The industrial production of the polysaccharide requires the cultivation of Hib in rich medium, which impacts process costs and product recovery. In this study, a central composite rotational experimental design strategy was used to access the influence of key components of culture medium (soy peptone, yeast extract and glucose) on biomass formation and polysaccharide production in shake-flasks...
August 25, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28836163/blood-glutamate-reducing-effect-of-hemofiltration-in-critically-ill-patients
#19
Evgeni Brotfain, Ruslan Kutz, Julia Grinshpun, Benjamin F Gruenbaum, Shaun E Gruenbaum, Amit Frenkel, Agzam Zhumadilov, Vladimir Zeldetz, Yoav Bichovsky, Matthew Boyko, Moti Klein, Alexander Zlotnik
Glutamate toxicity plays a well-established role in secondary brain damage following acute and chronic brain insults. Previous studies have demonstrated the efficacy of hemodialysis and peritoneal dialysis in reducing blood glutamate levels. However, these methods are not viable options for hemodynamically unstable patients. Given more favorable hemodynamics, longer treatment, and less needed anticoagulation, we investigated whether hemofiltration could be effective in lowering blood glutamate levels. Blood samples were taken from 10 critically ill patients immediately before initiation of hemofiltration and after 1, 2, 4, 6, and 12 h, for a total of 6 blood samples...
August 23, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28828678/novel-drug-delivery-of-dual-acting-prodrugs-of-hydroxychloroquine-with-aryl-acetic-acid-nsaids-design-kinetics-and-pharmacological-study
#20
Joshi Poorvashree, Dhaneshwar Suneela
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by restricted movements of joints of hand, feet, elbow, knees and neck but principally the synovial joints. Though etiopathology is not exactly known, treatment paradigms are evolving to provide a tighter control over symptoms and disease progression. Current trend is introduction of disease modifying anti-rheumatoid drugs (DMARDs) at early stages. Hydroxychloroquine (HCQ) and nonsteroidal anti-inflammatory drugs (NSAIDs) are two mechanistically different categories widely used in the management of RA where the first arrests the disease progression while the latter offers symptomatic relief...
August 21, 2017: Drug Delivery and Translational Research
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