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Physical frailty

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https://www.readbyqxmd.com/read/29778652/frailty-and-diabetes-among-mexican-american-older-adults
#1
Bret T Howrey, Soham Al Snih, Kyriakos S Markides, Kenneth J Ottenbacher
PURPOSE: Progressive physical frailty in older adults is associated with increased risk of falls, disability, institutionalization, and mortality. Although associations between diabetes and frailty have been observed, the impact of diabetes on frailty in older Hispanics is largely unexplored. We examine the association of diabetes on the odds of frailty among older Mexican Americans. METHODS: Using data from the Hispanic Established Population for the Epidemiological Study of the Elderly from 1995 until 2012, frailty was assessed by slow gait, weak hand grip strength, exhaustion, and unexplained weight loss (n = 1327)...
April 26, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29778642/benefits-of-a-multicomponent-falls-unit-based-exercise-program-in-older-adults-with-falls-in-real-life
#2
Rafael García Molina, Marta Carolina Ruíz Grao, Alicia Noguerón García, Marta Martínez Reig, Mariano Esbrí Víctor, Míkel Izquierdo Redín, Pedro Abizanda Soler
BACKGROUND/OBJECTIVES: Multicomponent exercise programs are the cornerstone in preventing gait and balance impairments and falls in older adults. However, the effects of these programs in usual clinical practice have been poorly analyzed. DESIGN: 4-Month, twice-a-week multicomponent exercise program cohort study in real-life. SETTING: Falls Unit, Complejo Hospitalario Universitario of Albacete, Spain. PARTICIPANTS: Sixty-seven participants who had experienced a fall in the previous year were included...
May 17, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29775746/anthropometric-measurements-and-mortality-in-frail-older-adults
#3
Jonathan F Easton, Christopher R Stephens, Heriberto Román-Sicilia, Matteo Cesari, Mario Ulises Pérez-Zepeda
BACKGROUND: As the number of older adults increases, so does the number of frail older adults. Although anthropometry has been widely used as a way to stratify the overall mortality risk of a person, the significance of these measurements becomes blurred in the case of frail older adults who have changes in body composition. Therefore, the aim of this study is to determine the association of anthropometric measurements (body mass index, knee-adjusted height body mass index, waist-to-hip ratio and calf circumference) with mortality risk in a group of older Mexican adults...
May 15, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29773704/effect-of-dietary-omega-3-fatty-acid-supplementation-on-frailty-related-phenotypes-in-older-adults-a-systematic-review-and-meta-analysis-protocol
#4
Joanne Stocks, Ana M Valdes
INTRODUCTION: The beneficial effect of dietary omega-3 supplementation in younger adults or older people with acute or chronic disease is established. Knowledge is now needed about the effect in medically stable older people. The objective of this study is to examine and assess the evidence for a role of dietary omega-3 polyunsaturated fatty acid (PUFA) supplementation in older adults on (1) muscle mass and muscle strength, (2) inflammatory biomarkers and (3) physical activity. METHODS AND ANALYSIS: A systematic review and data synthesis will be conducted of randomised controlled trials in older people not recruited for any given disease diagnosis...
May 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29773431/preoperative-frailty-assessment-predicts-loss-of-independence-after-vascular-surgery
#5
Graham W Donald, Amir A Ghaffarian, Farid Isaac, Larry W Kraiss, Claire L Griffin, Brigitte K Smith, Mark R Sarfati, Julie L Beckstrom, Benjamin S Brooke
OBJECTIVE: Frailty, a clinical syndrome associated with loss of metabolic reserves, is prevalent among patients who present to vascular surgery clinics for evaluation. The Clinical Frailty Scale (CFS) is a rapid assessment method shown to be highly specific for identifying frail patients. In this study, we sought to evaluate whether the preoperative CFS score could be used to predict loss of independence after major vascular procedures. METHODS: We identified all patients living independently at home who were prospectively assessed using the CFS before undergoing an elective major vascular surgery procedure (admitted for >24 hours) at an academic medical center between December 2015 and December 2017...
May 14, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29772594/-upper-age-limit-in-outpatient-anesthesia-opportunities-and-risks
#6
Tobias Hüppe, Nicole Kneller, Alexander Raddatz
Ambulatory surgery in elderly patients continues to increase - avoiding hospitalization and thus postoperative cognitive dysfunction in older patients being its major objectives. An upper age limit in outpatient anesthesia does not exist to date. However, functional rather than chronological age is crucial in patient selection. In consensus discussion, baseline functional status should be evaluated regularly - defined as everyday behaviors necessary to maintain daily life and encompassing areas of physical, cognitive, and social functioning...
May 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29762507/m-health-lessons-learned-by-m-experiences
#7
José Bravo, Ramón Hervás, Jesús Fontecha, Iván González
m-Health is an emerging area that is transforming how people take part in the control of their wellness condition. This vision is changing traditional health processes by discharging hospitals from the care of people. Important advantages of continuous monitoring can be reached but, in order to transform this vision into a reality, some factors need to be addressed. m-Health applications should be shared by patients and hospital staff to perform proper supervised health monitoring. Furthermore, the uses of smartphones for health purposes should be transformed to achieve the objectives of this vision...
May 15, 2018: Sensors
https://www.readbyqxmd.com/read/29761132/the-risk-factors-of-performance-based-early-frailty-in-midlife-and-older-age
#8
Matthew J Peterson
Background: Identifying impairments prior to onset of physical frailty may inform targeted interventions. An objective, clinically feasible early frailty measure, termed performance-based early frailty (PBEF) was developed, and antecedent and current risk factors were examined. Method: Data were from N = 104 participants of the Fels Longitudinal Study. PBEF was derived from age-specific cut points for time to complete five chair stands and walk four meters. "Pre-PBEF" and "PBEF" were defined as impairment in one or both measures, respectively...
January 2018: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29760608/calf-circumference-as-a-simple-screening-marker-for-diagnosing-sarcopenia-in-older-korean-adults-the-korean-frailty-and-aging-cohort-study-kfacs
#9
Sunyoung Kim, Miji Kim, Yunhwan Lee, ByungSung Kim, Tai Young Yoon, Chang Won Won
Background: The purpose of this study was to explore the optimal cut-off point of calf circumference (CC) as a simple proxy marker of appendicular skeletal muscle mass (ASM) and sarcopenia in the Korean elderly and to test the criterion-related validity of CC by analyzing its relationships with the physical function. Methods: The participants were 657 adults aged 70 to 84 years who had completed both dual energy X-ray absorptiometry (DXA) and physical function test in the first baseline year of the Korean Frailty and Aging Cohort Study...
May 14, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29759070/identifying-frailty-in-primary-care-a-qualitative-description-of-family-physicians-gestalt-impressions-of-their-older-adult-patients
#10
Clara Korenvain, Ida-Maisie Famiyeh, Sheila Dunn, Cynthia R Whitehead, Paula A Rochon, Lisa M McCarthy
BACKGROUND: Many tools exist to guide family physicians' impressions about frailty status of older adults, but no single tool, instrument, or set of criteria has emerged as most useful. The role of physicians' subjective impressions in frailty decisions has not been studied. This study explores how family physicians conceptualize frailty, and the factors that they consider when making subjective decisions about patients' frailty statuses. METHODS: Descriptive qualitative study of family physicians who practice in a large urban academic family medicine center as they participated in one-on-one "think-aloud" interviews about the frailty status of their patients aged 80 years and over...
May 14, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29755984/kampo-medicines-for-frailty-in-locomotor-disease
#11
REVIEW
Hajime Nakae, Yuko Hiroshima, Miwa Hebiguchi
Frailty is a syndrome that includes broad problems of senility and consists of three domains: physical, psychological, and social. Kampo medicine is used for intervention in cases of hypofunction in a mental or physical state. Kampo treatment, using Hojin formulations such as Hachimijiogan and Gosyajinkigan, is useful in patients with "jinkyo," or kidney hypofunction. Ketsu includes both blood and its metabolic products that circulate throughout the body. Oketsu is a disturbance of ketsu and is considered to be a microcirculation disorder...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29753582/the-biomarkers-associated-with-sarcopenia-and-physical-frailty-in-elderly-persons-biosphere-study-rationale-design-and-methods
#12
Riccardo Calvani, Anna Picca, Federico Marini, Alessandra Biancolillo, Matteo Cesari, Vito Pesce, Angela Maria Serena Lezza, Maurizio Bossola, Christiaan Leeuwenburgh, Roberto Bernabei, Francesco Landi, Emanuele Marzetti
Sarcopenia, the progressive and generalised loss of muscle mass and strength/function, is a major health issue in older adults given its high prevalence and burdensome clinical implications. Over the years, this condition has been endorsed as a marker for discriminating biological from chronological age. However, the absence of a unified operational definition has hampered its full appreciation by healthcare providers, researchers and policy-makers. In addition to this unsolved debate, the complexity of musculoskeletal ageing represents a major challenge to the identification of clinically meaningful biomarkers...
May 10, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29747183/influence-of-poor-oral-health-on-physical-frailty-a-population-based-cohort-study-of-older-british-men
#13
(no author information available yet)
Dental care professionals could play a role in the prevention of frailty.
May 11, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29742287/a-mobile-health-technology-enabled-home-based-intervention-to-treat-frailty-in-adult-lung-transplant-candidates-a-pilot-study
#14
Jonathan P Singer, Allison Soong, Alan Bruun, Ayana Bracha, Greg Chin, Steven R Hays, Jasleen Kukreja, Julia Rigler, Jeff A Golden, John R Greenland, Chris Garvey
BACKGROUND: Frailty is prevalent in lung transplant candidates (LTC) and is associated with waitlist delisting or death. We performed a pilot study to assess the safety and feasibility of a home-based, mobile-health technology facilitated intervention to treat frailty in LTC. METHODS: We performed an 8-week, non-randomized, home-based exercise and nutrition intervention in LTC with Short Physical Performance Battery (SPPB) frailty scores of ≤11. The intervention utilized a customized, mobile device application ("app") enabling monitoring and progression of the intervention in real-time...
May 9, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29741555/lower-blood-pressure-during-antihypertensive-treatment-is-associated-with-higher-all-cause-mortality-and-accelerated-cognitive-decline-in-the-oldest-old-data-from-the-leiden-85-plus-study
#15
Sven Streit, Rosalinde K E Poortvliet, Jacobijn Gussekloo
Background: the appropriateness of lowering systolic blood pressure remains controversial in the oldest-old. We tested whether systolic blood pressure is associated with all-cause mortality and change in cognitive function for patients prescribed antihypertensive treatment and those without treatment. Methods: we studied participants in the population-based Leiden 85-plus cohort study. Baseline systolic blood pressure and use of antihypertensive treatment were predictors; all-cause mortality and change in cognitive function measured using the Mini-Mental State Examination were the outcomes...
May 8, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29741197/how-to-manage-frail-older-adults-in-the-community-proposal-of-a-health-promotion-program-experienced-in-a-city-of-16-638-inhabitants-in-france
#16
J de Kerimel, N Tavassoli, C Lafont, M Soto, M Pedra, F Nourhashemi, C Lagourdette, L Bouchon, A Chaléon, S Sourdet, Y Rolland, M Cesari, B Vellas
BACKGROUND: Health promotion programs could prevent and delay frailty and functional decline. However, in practice, the planning and establishment of such a program is a challenge for health care providers. We report an experimental model of screening and management for frail elderly conducted in Cugnaux, city of 16,638 inhabitants in France, by the Toulouse Gerontopole and the social care service of the Cugnaux City Hall. METHODS: A frailty screening self-administered questionnaire (FiND questionnaire) was sent to community-dwelling residents of 70 years old and over of Cugnaux...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29741193/identifying-exosome-derived-micrornas-as-candidate-biomarkers-of-frailty
#17
B R Ipson, M B Fletcher, S E Espinoza, A L Fisher
Frailty is a geriatric syndrome associated with progressive physical decline and significantly increases risk for falls, disability, hospitalizations, and death. However, much remains unknown regarding the biological mechanisms that contribute to aging and frailty, and to date, there are no clinically used prognostic or diagnostic molecular biomarkers. The present study profiled exosome-derived microRNAs isolated from the plasma of young, robust older, and frail older individuals and identified eight miRNAs that are uniquely enriched in frailty: miR-10a-3p, miR-92a-3p, miR-185-3p, miR-194-5p, miR-326, miR-532-5p, miR-576-5p, and miR-760...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29734150/association-between-increases-in-normalized-protein-catabolic-rate-and-increases-in-creatinine-generation-rate-in-dialysis-patients
#18
Norio Hanafusa, Daigo Kamei, Misao Tsukada, Naoko Miwa, Mizuki Komatsu, Shunji Shiohira, Masayuki Okazaki, Ryota Watanabe, Hiroshi Kawaguchi, Ken Tsuchiya, Kosaku Nitta
The older dialysis population is growing, and malnutrition and wasting syndrome are great concerns in this population. The management of these syndromes includes appropriate nutritional intake and physical activity. However, whether management in the form of an increase in protein intake has a beneficial effect on muscle mass has not been demonstrated. In this study, we investigated an association between changes of normalized protein catabolic rate (nPCR), as a proxy for protein intake and percent creatinine generation rate (%CGR), as a proxy for muscle mass in patients receiving hemodialysis...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29733701/the-impact-of-sedentary-and-physical-activity-behaviour-on-frailty-in-middle-aged-and-older-adults
#19
Dustin Scott Kehler
Physical activity and sedentary behaviours are associated with frailty. However, it is unknown if different accumulation patterns of these behaviours are linked with frailty. Four studies were conducted: the first 3 determined if bouts of moderate-vigorous physical activity (MVPA) and patterns of sedentary behaviours were associated with frailty (study 1), and if sex (study 2) and cardiovascular disease (CVD) status (study 3) affected these associations. Study 4 systematically reviewed the evidence to determine if preoperative physical activity and sedentary behaviours were linked to postcardiac surgical outcomes...
May 7, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29730490/increased-double-limb-support-times-during-walking-in-right-limb-dominant-healthy-older-adults-with-low-bone-density
#20
Paul S Sung
BACKGROUND: Older adults with low bone mineral density (BMD) may exhibit early markers for physical frailty; however, there is a lack of understanding of the dominant limb support patterns during walking. RESEARCH QUESTION: The purpose of this study was to investigate limb support times during walking in healthy older adults with low BMD. METHODS: Seventy-seven right limb dominant older adults (48 female subjects, 29 male subjects) participated in the study...
April 25, 2018: Gait & Posture
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