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Physical frailty

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https://www.readbyqxmd.com/read/28079633/criterion-referenced-values-of-grip-strength-and-usual-gait-speed-using-instrumental-activities-of-daily-living-disability-as-the-criterion
#1
Meng-Chih Lee, Chih-Cheng Hsu, Yi-Fen Tsai, Ching-Yu Chen, Cheng-Chieh Lin, Ching-Yi Wang
BACKGROUND AND PURPOSE: Current evidence suggests that grip strength and usual gait speed (UGS) are important predictors of instrumental activities of daily living (IADL) disability. Knowing the optimum cut points of these tests for discriminating people with and without IADL disability could help clinicians or researchers to better interpret the test results and make medical decisions. The purpose of this study was to determine the cutoff values of grip strength and UGS for best discriminating community-dwelling older adults with and without IADL disability, separately for men and women, and to investigate their association with IADL disability...
January 10, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28077832/-frailty-and-its-related-factors-in-vulnerable-elderly-population-by-age-groups
#2
Eunok Park, Mi Yu
PURPOSE: This study aimed to investigate factors affecting frailty by age groups among vulnerable elders in Korea. METHODS: In this secondary analysis, data were collected from records for 22,868 eldesr registered in the Visiting Health Management program of Publci Health Centers in 2012. Health behaviors, clinically diagnosed disease, frailty, depression and cognitive condition were assessed. Data were analyzed using stepwise regression to determine the associated factors of frailty by age group...
December 2016: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28067869/clinical-and-biological-markers-of-premature-aging-after-autologous-sct-in-childhood-cancer
#3
A Vatanen, M Hou, T Huang, O Söder, T Jahnukainen, M Kurimo, T H Ojala, T Sarkola, M Turanlahti, U M Saarinen-Pihkala, K Jahnukainen
The aim of this study was to analyze the prevalence of frailty and physical health limitations among long-term survivors of high-risk neuroblastoma (HR NBL) and to investigate whether frail health is associated with variables of cardiovascular function, markers of inflammation and telomere length. A national study cohort of 19 (median age 22, range 16-30 years) long-term (>10 years) HR NBL survivors was studied and the findings were compared with 20 age- and sex-matched controls. Frailty was defined as ⩾3 of the following conditions: low muscle mass, low energy expenditure, slow running and weakness...
January 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28064173/interventions-to-prevent-or-reduce-the-level-of-frailty-in-community-dwelling-older-adults-a-scoping-review-of-the-literature-and-international-policies
#4
REVIEW
Martine T E Puts, Samar Toubasi, Melissa K Andrew, Maureen C Ashe, Jenny Ploeg, Esther Atkinson, Ana Patricia Ayala, Angelique Roy, Miriam Rodríguez Monforte, Howard Bergman, Kathy McGilton
BACKGROUND: frailty impacts older adults' ability to recover from an acute illness, injuries and other stresses. Currently, a systematic synthesis of available interventions to prevent or reduce frailty does not exist. Therefore, we conducted a scoping review of interventions and international policies designed to prevent or reduce the level of frailty in community-dwelling older adults. METHODS AND ANALYSIS: we conducted a scoping review using the framework of Arksey and O'Malley. We systematically searched articles and grey literature to identify interventions and policies that aimed to prevent or reduce the level of frailty...
January 6, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28064172/effectiveness-of-an-intervention-to-prevent-frailty-in-pre-frail-community-dwelling-older-people-consulting-in-primary-care-a-randomised-controlled-trial
#5
M Serra-Prat, X Sist, R Domenich, L Jurado, A Saiz, A Roces, E Palomera, M Tarradelles, M Papiol
BACKGROUND: evidence on the effectiveness of interventions to prevent frailty is scarce. OBJECTIVE: to assess the effect of an intervention in preventing frailty progression in pre-frail older people. STUDY DESIGN: a randomised, open label, controlled trial with two parallel arms. POPULATION: community-dwelling pre-frail older people (≥70 years) consulting in primary care. INTERVENTION: nutritional assessment (and derivation to a Nutritional Unit for usual care in the event of nutritional risk) and a physical activity programme including aerobic exercise and a set of mixed strengthening, balance and coordination exercises CONTROL GROUP: patients receiving the usual care...
January 6, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28062832/frailty-prefrailty-and-employment-outcomes-in-health-and-employment-after-fifty-heaf-study
#6
Keith T Palmer, Stefania D'Angelo, E Clare Harris, Cathy Linaker, Catharine R Gale, Maria Evandrou, Holly Syddall, Tjeerd van Staa, Cyrus Cooper, Avan Aihie Sayer, David Coggon, Karen Walker-Bone
OBJECTIVES: Demographic changes are requiring people to work longer. No previous studies, however, have focused on whether the 'frailty' phenotype (which predicts adverse events in the elderly) is associated with employment difficulties. To provide information, we assessed associations in the Health and Employment After Fifty Study, a population-based cohort of 50-65-year olds. METHODS: Subjects, who were recruited from 24 English general practices, completed a baseline questionnaire on 'prefrailty' and 'frailty' (adapted Fried criteria) and several work outcomes, including health-related job loss (HRJL), prolonged sickness absence (>20 days vs less, past 12 months), having to cut down substantially at work and difficulty coping with work's demands...
January 6, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28058805/biomarker-signatures-of-aging
#7
Paola Sebastiani, Bharat Thyagarajan, Fangui Sun, Nicole Schupf, Anne B Newman, Monty Montano, Thomas T Perls
Because people age differently, age is not a sufficient marker of susceptibility to disabilities, morbidities, and mortality. We measured nineteen blood biomarkers that include constituents of standard hematological measures, lipid biomarkers, and markers of inflammation and frailty in 4704 participants of the Long Life Family Study (LLFS), age range 30-110 years, and used an agglomerative algorithm to group LLFS participants into clusters thus yielding 26 different biomarker signatures. To test whether these signatures were associated with differences in biological aging, we correlated them with longitudinal changes in physiological functions and incident risk of cancer, cardiovascular disease, type 2 diabetes, and mortality using longitudinal data collected in the LLFS...
January 6, 2017: Aging Cell
https://www.readbyqxmd.com/read/28056846/biological-age-as-a-useful-index-to-predict-seventeen-year-survival-and-mortality-in-koreans
#8
Jinho Yoo, Yangseok Kim, Eo Rin Cho, Sun Ha Jee
BACKGROUND: Many studies have been conducted to quantitatively estimate biological age using measurable biomarkers. Biological age should function as a valid proxy for aging, which is closely related with future work ability, frailty, physical fitness, and/or mortality. A validation study using cohort data found biological age to be a superior index for disease-related mortality than chronological age. The purpose of this study is to demonstrate the validity of biological age as a useful index to predict a person's risk of death in the future...
January 5, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28049446/a-cross-sectional-study-of-the-association-between-dynapenia-and-higher-level-functional-capacity-in-daily-living-in-community-dwelling-older-adults-in-japan
#9
Masaki Iwamura, Masao Kanauchi
BACKGROUND: There are many reports that dynapenia, sarcopenia and frailty each have associations with bodily function or with Instrumental Activities of Daily Living (IADL). However, studies that compare all three conditions and their effects on IADL are lacking. The purpose of this study is to examine associations of sarcopenia, frailty, and dynapenia with IADL. METHODS: Participants included 123 community-dwelling older adults (31 men, 92 women,) aged 65 years or older (75...
January 3, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28043804/risk-factors-for-mild-cognitive-impairment-dementia-and-mortality-the-sydney-memory-and-ageing-study
#10
Darren M Lipnicki, John Crawford, Nicole A Kochan, Julian N Trollor, Brian Draper, Simone Reppermund, Kate Maston, Karen A Mather, Henry Brodaty, Perminder S Sachdev
BACKGROUND: The nature and commonality of late-life risk factors for mild cognitive impairment (MCI), dementia, and mortality remain unclear. Our aim was to investigate potential risk factors, simultaneously in a single cohort including many individuals initially with normal cognition and followed for 6 years. METHODS: We classified 873 community-dwelling individuals (70-90 years old and without dementia at baseline) from the Sydney Memory and Ageing Study as cognitively normal (CN), having MCI or dementia, or deceased 6 years after baseline...
December 31, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28042985/enhancing-elderly-health-examination-effectiveness-by-adding-physical-function-evaluations-and-interventions
#11
Chia-Ming Li, Ching-I Chang, Wen-Ruey Yu, Winnie Yang, Chih-Cheng Hsu, Ching-Yu Chen
This study aimed to assess the benefit of adding physical function evaluations and interventions to routine elderly health examination. This is a Quasi-experimental controlled trial. 404 elderly adults (aged 70 and over) scoring 3-6 on the Canadian Study of Health and Aging Clinical Frailty Scale Chinese In-Person Interview Version (CSHA-CFS) in a 2012 annual elderly health examination were enrolled. Both the control and experimental groups received the routine annual health examination with the latter further provided with functional evaluations, exercise instruction, and nutrition education...
December 24, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28039014/what-can-five-high-cost-patients-teach-us-about-healthcare-spending
#12
Ishani Ganguli, Ryan W Thompson, Timothy G Ferris
The highest cost patients account for a disproportionately large share of American healthcare costs and are increasingly the focus of research and policy efforts to stem the rapid growth of these costs. These patients tend to be medically complex and frail, but we know little about how such characteristics influence healthcare spending from the perspectives of the patients and their caregivers. Therefore, we examined five of the highest cost patients at an academic medical center in a case series. We interviewed the patients, their family members, and their clinicians and analyzed their claims data and medical charts to explore how patient and health system characteristics influenced their health costs...
December 27, 2016: Healthcare
https://www.readbyqxmd.com/read/28030710/association-of-radiologic-indicators-of-frailty-with-1-year-mortality-in-older-trauma-patients-opportunistic-screening-for-sarcopenia-and-osteopenia
#13
Stephen J Kaplan, Tam N Pham, Saman Arbabi, Joel A Gross, Mamatha Damodarasamy, Itay Bentov, Lisa A Taitsman, Steven H Mitchell, May J Reed
Importance: Assessment of physical frailty in older trauma patients admitted to the intensive care unit is often not feasible using traditional frailty assessment instruments. The use of opportunistic computed tomography (CT) scans to assess sarcopenia and osteopenia as indicators of underlying frailty may provide complementary prognostic information on long-term outcomes. Objective: To determine whether sarcopenia and/or osteopenia are associated with 1-year mortality in an older trauma patient population...
December 28, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/28024721/functional-and-cognitive-impairment-social-environment-frailty-and-adverse-health-outcomes-in-older-patients-with-head-and-neck-cancer-a-systematic-review
#14
REVIEW
Floor J van Deudekom, Anouk S Schimberg, Marije H Kallenberg, Marije Slingerland, Lily-Ann van der Velden, Simon P Mooijaart
OBJECTIVES: Older head and neck cancer patients are at increased risk for adverse health outcomes, but little is known about which geriatric assessment associates with poor outcome. The aim is to study the association of functional or cognitive impairment, social environment and frailty with adverse health outcomes in patients with head and neck cancer. METHODS: Four libraries were searched for studies reporting on an association of functional or cognitive impairment, social environment and frailty with adverse outcomes in head and neck cancer patients...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28012505/reversible-cognitive-frailty-dementia-and-all-cause-mortality-the-italian-longitudinal-study-on-aging
#15
Vincenzo Solfrizzi, Emanuele Scafato, Davide Seripa, Madia Lozupone, Bruno P Imbimbo, Angela D'Amato, Rosanna Tortelli, Andrea Schilardi, Lucia Galluzzo, Claudia Gandin, Marzia Baldereschi, Antonio Di Carlo, Domenico Inzitari, Antonio Daniele, Carlo Sabbà, Giancarlo Logroscino, Francesco Panza
OBJECTIVES: Cognitive frailty, a condition describing the simultaneous presence of physical frailty and mild cognitive impairment, has been recently defined by an international consensus group. We estimated the predictive role of a "reversible" cognitive frailty model on incident dementia, its subtypes, and all-cause mortality in nondemented older individuals. We verified if vascular risk factors or depressive symptoms could modify this predictive role. DESIGN: Longitudinal population-based study with 3...
January 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28008596/the-association-of-vitamin-d-deficiency-and-incident-frailty-in-older-women-the-role-of-cardiometabolic-diseases
#16
Brian Buta, Parichoy Pal Choudhury, Qian-Li Xue, Paulo Chaves, Karen Bandeen-Roche, Michelle Shardell, Richard D Semba, Jeremy Walston, Erin D Michos, Lawrence J Appel, Mara McAdams-DeMarco, Alden Gross, Sevil Yasar, Luigi Ferrucci, Linda P Fried, Rita Rastogi Kalyani
OBJECTIVES: Evidence suggests vitamin D deficiency is associated with developing frailty. However, cardiometabolic factors are related to both conditions and may confound and/or mediate the vitamin D-frailty association. We aimed to determine the association of vitamin D concentration with incidence of frailty, and the role of cardiometabolic diseases (cardiovascular disease, diabetes, hyperlipidemia, hypertension) in this relationship. DESIGN: Prospective longitudinal cohort study (7 visits from 1994-2008)...
December 23, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28005921/association-of-functional-impairments-and-co-morbid-conditions-with-driving-performance-among-cognitively-normal-older-adults
#17
David B Carr, Peggy P Barco, Ganesh M Babulal, Sarah H Stout, Anne M Johnson, Chengjie Xiong, John C Morris, Catherine M Roe
OBJECTIVES: To examine the relationship between key functional impairments, co-morbid conditions and driving performance in a sample of cognitively normal older adults. DESIGN: Prospective observational study. SETTING: The Knight Alzheimer's Disease Research Center, Washington University at St. Louis. PARTICIPANTS: Individuals with normal cognition, 64.9 to 88.2 years old (N = 129), with a valid driver's license, who were currently driving at least once per week, and who had participated in longitudinal studies at the Knight Alzheimer's Disease Research Center...
2016: PloS One
https://www.readbyqxmd.com/read/28005830/do-older-adults-who-meet-2008-physical-activity-guidelines-have-better-physical-performance-than-those-who-do-not-meet
#18
Elaine Trudelle-Jackson, Allen W Jackson
BACKGROUND AND PURPOSE: An observed consequence of aging is a decline in muscle performance that includes a loss in both muscle strength and muscle power. This decline can lead to loss of function and independence and is a predictor of disability in older adults. Although the 2008 Physical Activity (PA) Guidelines for Americans provides a guideline for muscle strengthening, there is no evidence that performing muscle strengthening 2 times a week for all major muscle groups is related to better performance on measures known to be important factors in development or progression of frailty in older adults...
December 21, 2016: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28004299/evaluation-of-sarcopenia-in-patients-with-distal-radius-fractures
#19
Young Hak Roh, Young Do Koh, Jung Ho Noh, Hyun Sik Gong, Goo Hyun Baek
: Sarcopenia is more prevalent in patients with distal radius fracture (DRF) than in age- and sex-matched controls. Lower appendicular mass index in men and weaker grip strength in both men and women increase the likelihood of DRF. INTRODUCTION: Sarcopenia is a core component of physical frailty that predisposes older people to falls and negatively impacts the activities of daily living. The objectives of this study were to compare the prevalence of sarcopenia in patients with DRF with that in age- and sex-matched controls without DRF; and evaluate the association between sarcopenia and the occurrence of DRF...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28000719/association-between-low-grade-albuminuria-and-frailty-among-community-dwelling-middle-aged-and-older-people-a-cross-sectional-analysis-from-i-lan-longitudinal-aging-study
#20
Chun-Chin Chang, Chien-Yi Hsu, Ting-Yung Chang, Po-Hsun Huang, Li-Kuo Liu, Liang-Kung Chen, Jaw-Wen Chen, Shing-Jong Lin
Frailty is characterized by decreased physiological reserve and increased vulnerability to atherosclerosis and subsequent mortality. Recently, low-grade albuminuria has been proposed as an atherosclerotic risk factor. We aimed to investigate the relationship between low-grade albuminuria and frailty by using cross-sectional data among community-dwelling middle-aged and older people. Totally, 1,441 inhabitants of I-Lan County with normal urinary albumin excretion (urine albumin to urine creatinine ratio [UACR] <30 mg/g) were enrolled (677 men; mean age 63 ± 9 years, range from 50 to 91 years old)...
December 21, 2016: Scientific Reports
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