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https://www.readbyqxmd.com/read/28817616/patterns-of-statin-non-prescription-in-patients-with-established-coronary-artery-disease-a-report-from-a-contemporary-multicenter-japanese-pci-registry
#1
Mitsuaki Sawano, Shun Kohsaka, Takayuki Abe, Taku Inohara, Yuichiro Maekawa, Ikuko Ueda, Koichiro Sueyoshi, Masahiro Suzuki, Shigetaka Noma, Yohei Numasawa, Hiroaki Miyata, Keiichi Fukuda, Kim G Smolderen, John A Spertus
Statin therapy is regarded as an effective medication to reduce cardiovascular events in patients at higher risk for future incidence of coronary artery disease. However, very few studies have been conducted to examine its implementation in non-Western real-world practice. In this study, we sought to describe statin prescription patterns in relation to patient characteristics in a Japanese multicenter percutaneous coronary intervention (PCI) registry as a foundation for quality improvement. We studied 15,024 patients that were prospectively enrolled in the Japan Cardiovascular Database-Keio interhospital Cardiovascular Study Registry from January 2009 to August 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28815734/long-term-mortality-in-patients-with-stemi-transported-primary-or-secondary-to-the-cardiac-center-and-treated-by-primary-pci
#2
Abdulwasya Almawiri, Vojacek Jan, Albahri Ziad, Jakl Martin, Stasek Josef
BACKGROUND: The purpose of this study was to compare long-term outcomes of primary transport (PT) and secondary transport (ST) in patients with STEMI. METHOD: We assigned consecutive 869 patients referred for STEMI during a 2-year period (2008-2009). The primary endpoint was to compare long-term outcomes and mortality of PT to a catheterization laboratory and ST from regional hospitals to a catheterization laboratory. Six hundred seventy-seven patients (77.9%) were enrolled for the final evaluation, 192 (22...
August 16, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28811677/the-relationship-between-vegfa-and-tgfb1-polymorphisms-and-target-lesion-revascularization-after-elective-percutaneous-coronary-intervention
#3
Tadeusz Osadnik, Andrzej Lekston, Kamil Bujak, Joanna Katarzyna Strzelczyk, Lech Poloński, Mariusz Gąsior
BACKGROUND AND AIM: The specific association between genetic variation and in-stent restenosis is still only partly understood. The aim of this study is to analyze the relationship between functional polymorphisms in the genes encoding vascular endothelial growth factor A (VEGF-A; rs699947) and transforming growth factor beta 1 (TGF-β1; rs1800470) and target lesion revascularization (TLR) risk. METHODS: A total of 676 patients (805 lesions) with stable coronary artery disease (SCAD) who received elective percutaneous coronary intervention (PCI) with at least one bare-metal stent implantation were included...
2017: Disease Markers
https://www.readbyqxmd.com/read/28807393/treatment-trends-effectiveness-and-safety-of-statins-on-lipid-goal-attainment-in-chinese-percutaneous-coronary-intervention-patients-a-multicenter-retrospective-cohort-study
#4
Yundai Chen, Dandan Li, Jing Jing, Hongbing Yan, Jinghua Liu, Zhujun Shen, Stefan James, Christoph Varenhorst
PURPOSE: Limited data exist on the use of statins in Chinese patients with coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI). We therefore conducted this study to observe the usage trend and the effectiveness of statins on LDL-C goal attainment and other lipid parameters among PCI-treated patients. METHODS: This multicenter, retrospective, observational, longitudinal cohort study was conducted in PCI-treated patients with CAD between July 1, 2011, and February 28, 2015...
August 11, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28804231/preliminary-report-on-the-safety-and-efficacy-of-staged-versus-complete-revascularization-in-patients-with-multivessel-disease-at-the-time-of-primary-percutaneous-coronary-intervention
#5
Marwan Saad, Ahmed Rashed, Wael El-Kilany, Mohamed El-Haddad, Islam Y Elgendy
This study aims to determine the safety and efficacy of complete versus staged-percutaneous coronary intervention (PCI) of nonculprit lesions at the time of primary PCI in patients with multivessel disease. Recent trials had suggested that revascularization of nonculprit lesions at the time of primary PCI is associated with better outcomes, however; the optimum timing and overall safety of this approach is not well known. An observational prospective study was conducted, including 50 patients who presented with ST-segment elevation myocardial infarction and found to have at least an additional nonculprit significant (> 70%) type A or B lesion...
September 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28802512/cangrelor-versus-clopidogrel-on-a-background-of-unfractionated-heparin-from-champion-phoenix
#6
Muthiah Vaduganathan, Robert A Harrington, Gregg W Stone, Ph Gabriel Steg, C Michael Gibson, Christian W Hamm, Matthew J Price, Efthymios N Deliargyris, Jayne Prats, Kenneth W Mahaffey, Harvey D White, Deepak L Bhatt
Cangrelor is approved for use during percutaneous coronary intervention (PCI) and is administered with different parenteral anticoagulants. We examined the efficacy and safety of cangrelor in the subgroup of patients who received unfractionated heparin (UFH) during PCI in the modified intention-to-treat population of the randomized CHAMPION PHOENIX trial (cangrelor vs clopidogrel; n = 10,939). The primary efficacy end point was the composite of death, myocardial infarction, ischemia-driven revascularization, or stent thrombosis (ST) at 48 hours...
July 18, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28801225/temporal-trends-in-the-clinical-acuity-of-patients-with-st-segment-elevation-myocardial-infarction
#7
Udhay Krishnan, Josef A Brejt, Joshua Schulman-Marcus, Rajesh V Swaminathan, Dmitriy N Feldman, Parag Goyal, S Chiu Wong, Robert M Minutello, Geoffrey Bergman, Harsimran Singh, Luke K Kim
BACKGROUND: Despite advances in ST-elevation myocardial infarction (STEMI) systems of care over the last decade, studies have shown no improvement in risk-adjusted mortality. It has been hypothesized that the population presenting to the catheterization lab has become sicker over time, in ways not accurately captured by current mortality models. OBJECTIVE: The objective of this study was to examine changes in the clinical characteristics and in-hospital case fatality rate of the STEMI population treated with early percutaneous coronary intervention (PCI)...
August 8, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28799712/deferred-or-immediate-stent-implantation-for-primary-percutaneous-coronary-intervention-a-meta-analysis-of-randomized-trials
#8
Ahmed N Mahmoud, Marwan Saad, Akram Y Elgendy, Amgad Mentias, Islam Y Elgendy
OBJECTIVES: To perform a meta-analysis of randomized trials comparing a deferred versus immediate stenting strategy for primary percutaneous coronary intervention (PCI). BACKGROUND: Deferred stent implantation has emerged as a potential strategy aiming to reduce the thrombus burden and improve micro-vascular reperfusion during primary PCI. METHODS: Electronic databases were searched for randomized trials that compared a deferred stent implantation versus immediate stent implantation strategy in patients undergoing primary PCI...
August 11, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28797607/trends-and-clinical-outcomes-in-patients-undergoing-primary-percutaneous-revascularisation-for-st-elevation-myocardial-infarction-a-single-centre-experience
#9
Luke P Dawson, Josephine Warren, Juan Mundisugih, Viveka Nainani, William Chan, Dion Stub, Archer Broughton, Andrew J Taylor, Antony Walton, Stephen J Duffy, James A Shaw
BACKGROUND: Primary percutaneous coronary intervention (PPCI) is the preferred therapy for patients presenting with ST-elevation myocardial infarction (STEMI). We reviewed patients undergoing PCI for STEMI over a six-year period to evaluate changes in procedural characteristics and clinical outcomes given recent changes to STEMI guidelines. METHODS: All patients presenting to the Alfred Hospital, a tertiary referral hospital, between 1 January 2010 and 31 December 2015 undergoing PCI for STEMI were identified...
July 14, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28797425/differential-rates-and-clinical-significance-of-periprocedural-myocardial-infarction-after-stenting-or-bypass-surgery-for%C3%A2-multivessel-coronary-disease-according-to-various-definitions
#10
Min Soo Cho, Jung-Min Ahn, Cheol-Hyun Lee, Do-Yoon Kang, Jung-Bok Lee, Pil Hyung Lee, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Duk-Woo Park, Seung-Jung Park
OBJECTIVES: This study sought to estimate the differential incidence and prognostic significance of periprocedural myocardial infarction (MI) according to various definitions. BACKGROUND: In trials comparing percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG), the primary composite endpoint is very sensitive to the definition of MI. Especially, the definition of periprocedural MI has considerably varied, and uniform criteria are still unsettled...
August 14, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28797009/left-main-coronary-stenosis-surgery-still-reigns
#11
Marc Ruel, Hidetake Kawajiri, David Glineur, Juan Grau, Mario Gaudino, Subodh Verma
PURPOSE OF REVIEW: Coronary artery bypass grafting (CABG) has been regarded as the mainstream treatment for unprotected left main coronary artery (ULMCA) stenosis. However, the results of the Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization (EXCEL) trial, in which percutaneous coronary intervention (PCI) was deemed noninferior to CABG, have raised a question whether the guidelines should be changed. This article provides a critical appraisal of recent randomized control trials (RCTs) on ULMCA stenosis...
September 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28796845/improved-early-risk-stratification-of-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention-using-a-combination-of-serum-soluble-st2-and-nt-probnp
#12
Jongwook Yu, Pyung Chun Oh, Minsu Kim, Jeonggeun Moon, Yae Min Park, Kyounghoon Lee, Soon Yong Suh, Seung Hwan Han, Kyunghee Byun, Taehoon Ahn, Woong Chol Kang
BACKGROUND: Although soluble suppression of tumorigenicity 2 (sST2) in serum is known to be associated with ischemic heart disease and heart failure, data regarding its prognostic impact in ST-segment elevation myocardial infarction (STEMI) is limited. We evaluated the prognostic impacts of serum sST2 and other serum biomarkers in STEMI patients undergoing primary percutaneous coronary intervention (PCI). METHODS: Consecutive all 323 patients with STEMI that underwent primary PCI were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28796809/a-randomized-multicenter-trial-comparing-the-xience-everolimus-eluting-stent-with-the-cypher-sirolimus-eluting-stent-in-the-treatment-of-female-patients-with-de-novo-coronary-artery-lesions-the-spirit-women-study
#13
Anna Franzone, Serge Zaugg, Raffaele Piccolo, Maria Grazia Modena, Ghada W Mikhail, Josepa Mauri Ferré, Ruth Strasser, Liliana Grinfeld, Dik Heg, Peter Jüni, Stephan Windecker, Marie-Claude Morice
BACKGROUND: The comparative performance of different drug-eluting stents (DES) among female patients has not been assessed in a randomized manner. OBJECTIVES: The SPIRIT Women Clinical Evaluation trial compared the durable polymer everolimus-eluting XIENCE stent (DP-EES) with the durable polymer sirolimus-eluting Cypher stent (DP-SES) in women undergoing percutaneous coronary intervention (PCI). METHODS: A total of 455 female patients with stable CAD were randomly assigned to receive DP-EES (n = 304) or DP-SES (n = 151)...
2017: PloS One
https://www.readbyqxmd.com/read/28795098/data-on-administration-of-cyclosporine-nicorandil-metoprolol-on-reperfusion-related-outcomes-in-st-segment-elevation-myocardial-infarction-treated-with-percutaneous-coronary-intervention
#14
Gianluca Campo, Rita Pavasini, Giampaolo Morciano, Michael A Lincoff, Michael C Gibson, Masafumi Kitakaze, Jacob Lonborg, Amrita Ahluwalia, Hideki Ishii, Michael Frenneaux, Michel Ovize, Marcello Galvani, Dan Atar, Borja Ibanez, Giampaolo Cerisano, Simone Biscaglia, Brandon J Neil, Masanori Asakura, Thomas Engstrom, Daniel A Jones, Dana Dawson, Roberto Ferrari, Paolo Pinton, Filippo Ottani
Mortality and morbidity in patients with ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) are still high [1]. A huge amount of the myocardial damage is related to the mitochondrial events happening during reperfusion [2]. Several drugs directly and indirectly targeting mitochondria have been administered at the time of the PCI and their effect on fatal (all-cause mortality, cardiovascular (CV) death) and non fatal (hospital readmission for heart failure (HF)) outcomes have been tested showing conflicting results [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28795029/comparison-of-coronary-artery-bypass-graft-first-and-percutaneous-coronary-intervention-first-approaches-for-2-stage-hybrid-coronary-revascularization
#15
Hang Jun Choi, Joonkyu Kang, Hyun Song, Do Yeon Kim, Kuk Bin Choi
BACKGROUND: Hybrid coronary revascularization (HCR) was developed to combine the advantages of coronary artery bypass graft (CABG) with percutaneous coronary intervention (PCI). However, it is still controversial whether it is more optimal to perform CABG or PCI first. The purpose of this study was to compare the clinical outcomes of these 2 approaches. METHODS: Eighty patients who underwent HCR from May 2010 to December 2015 were enrolled in this retrospective analysis...
August 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28792139/sarpogrelate-based-triple-antiplatelet-therapy-improved-left-ventricular-systolic-function-in-acute-myocardial-infarction-retrospective-study
#16
Jae Hyuk Choi, Jung Rae Cho, Sang Min Park, Kunal Bikram Shaha, Floyd Pierres, Tserendavaa Sumiya, Kwang Jin Chun, Min Kyung Kang, Seonghoon Choi, Namho Lee
PURPOSE: The purpose of this study was to assess the potential benefit of a 5-hydroxytryptamine receptor antagonist, sarpogrelate-based triple antiplatelet therapy (TAPT) in comparison with dual antiplatelet therapy (DAPT) in patients undergoing primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI). MATERIALS AND METHODS: 119 patients of STEMI were retrospectively assessed. All patients received aspirin and clopidogrel per standard of care...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28790165/prognostic-value-of-fractional-flow-reserve-measured-immediately-after-drug-eluting-stent-implantation
#17
Zsolt Piroth, Gabor G Toth, Pim A L Tonino, Emanuele Barbato, Soheila Aghlmandi, Nick Curzen, Gilles Rioufol, Nico H J Pijls, William F Fearon, Peter Jüni, Bernard De Bruyne
BACKGROUND: The predictive value of fractional flow reserve (FFR) measured immediately after percutaneous coronary intervention (PCI) with drug-eluting stent placement has not been prospectively investigated. We investigated the potential of post-PCI FFR measurements to predict clinical outcome in patients from FAME 1 and 2 trials (Fractional Flow Reserve or Angiography for Multivessel Evaluation). METHODS AND RESULTS: All patients of FAME 1 and FAME 2 who had post-PCI FFR measurement were included...
August 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28789842/impact-of-target-vessel-on-long-term-cardiac-mortality-after-successful-chronic-total-occlusion-percutaneous-coronary-intervention-insights-from-a-japanese-multicenter-registry
#18
Satoru Mitomo, Toru Naganuma, Richard J Jabbour, Katsumasa Sato, Hideo Takebayashi, Tsuyoshi Kobayashi, Jun-Ei Obata, Kenji Sakamoto, Kenichi Tsujita, Kiyotaka Kugiyama, Hisao Ogawa, Sunao Nakamura
BACKGROUND: The impact of successful chronic total occlusion (S-CTO) percutaneous coronary intervention (PCI) on cardiac mortality may differ depending on target CTO vessel; however, to date this has not yet been adequately evaluated. The aim of this study was to investigate the impact of target vessel on cardiac mortality after S-CTO PCI. METHODS: From January 2004 to December 2011, 1517 CTO PCIs were performed in 4 Japanese centers and enrolled in a multicenter registry...
August 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28780839/-feasibility-and-value-of-index-of-microcirculatory-resistance-in-patients-with-acute-myocardial-infarction-after-primary-percutaneous-coronary-intervention
#19
J L Han, L Y He, M Cui, Y Z Zhang, X B Liu, X Y Xu, Y P Wang, F F Wang, G S Wang, J Niu, F C Zhang, L Mi, L J Guo, W Gao
Objective: To evaluate the feasibility of detecting index of microcirculatory resistance (IMR) and the relationship between IMR and left ventricular (LV) systolic function after acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI). Methods: The patients with first AMI received primary PCI in Peking University Third Hospital were enrolled from January 2014 to March 2016. IMR were measured immediately after PCI by using pressure/temperature wire. The relationship between IMR and left ventricular ejection fraction (LVEF) assessed by echocardiography at first day and 6 months after admission was evaluated...
August 1, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28779859/double-right-coronary-artery-in-primary-pci-finding-the-hidden-treasure%C3%A2
#20
Luciano Candilio, Roberto Nerla, Jonathan Byrne
Double Right Coronary Artery (RCA) is one of the rarest congenital coronary anomalies. Although it can be regarded as a benign condition in the vast majority of cases, it has been associated with acute and life-threatening presentations, including inferior ST-segment elevation myocardial infarction (STEMI), cardiogenic shock and complete heart block, tachyarrhythmias, or even sudden death. However, the role of a double RCA in these conditions is yet to be clarified as more recent data prove no statistically significant association between prevalence of significant atherosclerosis in anomalous coronary arteries in comparison to normal coronary arteries...
July 5, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
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