keyword
https://read.qxmd.com/read/38643692/ultrasound-driven-facile-fabrication-of-pd-doped-sno-2-hierarchical-superstructures-structural-growth-mechanism-dermatoglyphics-and-anti-cancer-activity
#21
JOURNAL ARTICLE
B R Radha Krushna, K Manjunatha, Sheng Yun Wu, D Sivaganesh, S C Sharma, C Sridhar, Fr Deepu Joy, H Ramesha, Nagarjun Prakash Dalbanjan, K S Devaraju, H Nagabhushana
This research introduces a novel method that leverages Spirulina extract (S.E) as a bio-surfactant in the ultrasound-assisted synthesis (UAS) of Pd3+ (0.25-10 mol%) doped tin oxide (SnO2 ) self-assembled superstructures. Nanotechnology has witnessed significant advancements in recent years, driven by the exploration of novel synthesis methods and the development of advanced nanomaterials tailored for specific applications. Metal oxide nanoparticles, particularly SnO2 , have garnered considerable attention due to their versatile properties and potential applications in various fields, including gas sensing, catalysis, and biomedical engineering...
April 16, 2024: Biomater Adv
https://read.qxmd.com/read/38643680/information-and-communication-priorities-of-patients-and-healthcare-professionals-in-shared-decision-making-regarding-adjuvant-systemic-breast-cancer-treatment-a-survey-study
#22
JOURNAL ARTICLE
Olga C Damman, Inge S van Strien-Knippenberg, Ellen G Engelhardt, Domino Determann D, Martine C de Bruijne, Sabine Siesling, Inge R Konings, Danielle R Timmermans
PURPOSE: To assess information and communication priorities of patients and healthcare professionals in Shared Decision Making about adjuvant systemic treatment of primary breast cancer and identify key decision-relevant information accordingly. METHODS: Patients (N = 122) and professionals working with breast cancer patients (N = 118), of whom 38 were nurse practitioners and 32 nurses, were recruited using convenience sampling, and surveyed about information/communication aspects key to decision-making, using ranking assignments...
April 10, 2024: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://read.qxmd.com/read/38643308/correction-a-multidisciplinary-approach-to-address-unmet-needs-in-the-management-of-patients-with-non-metastatic-castration-resistant-prostate-cancer
#23
Neal D Shore, Emmanuel S Antonarakis, Ashley E Ross, Catherine H Marshall, Kelly L Stratton, Adanma Ayanambakkam, Michael S Cookson, Rana R McKay, Alan H Bryce, Marina D Kaymakcalan
No abstract text is available yet for this article.
April 20, 2024: Prostate Cancer and Prostatic Diseases
https://read.qxmd.com/read/38643180/diet-changes-due-to-urbanization-in-south-africa-are-linked-to-microbiome-and-metabolome-signatures-of-westernization-and-colorectal-cancer
#24
JOURNAL ARTICLE
M C Ramaboli, S Ocvirk, M Khan Mirzaei, B L Eberhart, M Valdivia-Garcia, A Metwaly, K Neuhaus, G Barker, J Ru, L T Nesengani, D Mahdi-Joest, A S Wilson, S K Joni, D C Layman, J Zheng, R Mandal, Q Chen, M R Perez, S Fortuin, B Gaunt, D Wishart, B Methé, D Haller, J V Li, L Deng, R Swart, S J D O'Keefe
Transition from traditional high-fiber to Western diets in urbanizing communities of Sub-Saharan Africa is associated with increased risk of non-communicable diseases (NCD), exemplified by colorectal cancer (CRC) risk. To investigate how urbanization gives rise to microbial patterns that may be amenable by dietary intervention, we analyzed diet intake, fecal 16 S bacteriome, virome, and metabolome in a cross-sectional study in healthy rural and urban Xhosa people (South Africa). Urban Xhosa individuals had higher intakes of energy (urban: 3,578 ± 455; rural: 2,185 ± 179 kcal/d), fat and animal protein...
April 20, 2024: Nature Communications
https://read.qxmd.com/read/38643028/transthyretin-amyloid-polyneuropathy-in-france-a-cross-sectional-study-with-413-patients-and-real-world-tafamidis-meglumine-use-2009-2019
#25
JOURNAL ARTICLE
D Adams, P Cintas, G Solé, C Tard, C Labeyrie, A Echaniz-Laguna, C Cauquil, Y Pereon, L Magy, R Juntas Morales, J C Antoine, E Lagrange, P Petiot, M Mallaret, B Francou, A Guiochon-Mantel, A Coste, O Demarcq, C Geffroy, V Famelart, J Rudant, M Bartoli, E Donal, O Lairez, J C Eicher, M Kharoubi, S Oghina, J N Trochu, J Inamo, G Habib, F Roubille, A Hagège, F Morio, E Cariou, J Adda, M S Slama, P Charron, V Algalarrondo, T Damy, S Attarian
OBJECTIVE: We aimed to describe characteristics of patients with ATTR variant polyneuropathy (ATTRv-PN) and ATTRv-mixed and assess the real-world use and safety profile of tafamidis meglumine 20mg. METHODS: Thirty-eight French hospitals were invited. Patient files were reviewed to identify clinical manifestations, diagnostic methods, and treatment compliance. RESULTS: Four hundred and thirteen patients (296 ATTRv-PN, 117 ATTRv-mixed) were analyzed...
April 19, 2024: Revue Neurologique
https://read.qxmd.com/read/38642889/a-trial-of-implementation-facilitation-to-increase-timely-admission-to-methadone-treatment
#26
JOURNAL ARTICLE
J Gryczynski, S G Mitchell, M Whitter, D Fuller, M M Mitchell, E J Edelman, R P Schwartz
BACKGROUND: During the ongoing opioid epidemic, some Opioid Treatment Programs (OTPs) are unable to admit program applicants in a timely fashion. Interim methadone (IM) treatment (without routine counseling) is an effective approach to overcome this challenge when counseling capacity is inadequate to permit admissions within 14 days of request. It requires both federal and state approval and has been rarely utilized since its incorporation into the federal OTP regulations in 1993...
April 18, 2024: J Subst Use Addict Treat
https://read.qxmd.com/read/38642791/ageing-influences-the-toxicity-of-two-innovative-nanofertilizers-to-the-soil-invertebrates-enchytraeus-crypticus-and-folsomia-candida
#27
JOURNAL ARTICLE
C Malheiro, M Prodana, D N Cardoso, R G Morgado, S Loureiro
The increasing global food demand is threatening the sustainability of agrifood production systems. The intensification of agricultural practices, with inadequate use of pesticides and fertilizers, poses major challenges to the good functioning of agroecosystems and drastically degrades the soil quality. Nanotechnology is expected to optimize the current farming practices and mitigate some associated impacts. Layered double hydroxides (LDHs) are a class of nanomaterials with high potential for use in agricultural productions, mostly due to their sustained release of nutrients...
April 18, 2024: Environmental Pollution
https://read.qxmd.com/read/38642709/efficacy-and-safety-of-systemic-corticosteroids-for-urticaria-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#28
JOURNAL ARTICLE
Xiajing Chu, Jason Wang, Leonardo Ologundudu, Romina Brignardello-Petersen, Gordon H Guyatt, Paul Oykhman, Jonathan A Bernstein, Sarbjit S Saini, Lisa A Beck, Susan Waserman, Joseph Moellman, Dave A Khan, Moshe Ben-Shoshan, Diane R Baker, Eric T Oliver, Javed Sheikh, David Lang, Sameer K Mathur, Tonya Winders, Sanaz Eftekhari, Donna D Gardner, Lauren Runyon, Rachel N Asiniwasis, Emily F Cole, Jeffrey Chan, Kathryn E Wheeler, Kathryn P Trayes, Paul Tran, Derek K Chu
BACKGROUND: Short courses of adjunctive systemic corticosteroids are commonly used to treat acute urticaria and chronic urticaria flares (both with or without mast cell-mediated angioedema), but their benefits and harms are unclear. OBJECTIVE: To evaluate the efficacy and safety of treating acute urticaria or chronic urticaria flares with versus without systemic corticosteroids. METHODS: We searched MEDLINE, EMBASE, CENTRAL, CNKI, VIP, Wanfang, and CBM databases from inception to July 8, 2023 for randomized controlled trials of treating urticaria with versus without systemic corticosteroids...
April 18, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38642658/the-ovarian-function-and-endocrine-phenotypes-of-lactating-dairy-cows-during-the-estrous-cycle-were-associated-with-genomic-enhanced-predictions-of-fertility-potential
#29
JOURNAL ARTICLE
E M Sitko, A Laplacette, D Duhatschek, C Rial, M M Perez, S Tompkins, A L Kerwin, R R Domingues, M C Wiltbank, J O Giordano
The objectives of this prospective cohort study were to characterize associations among genomic merit for fertility with ovarian and endocrine function and the estrous behavior of dairy cows during an entire, non-hormonally manipulated estrous cycle. Lactating Holstein cows entering their first (n = 82) or second (n = 37) lactation had ear-notch tissue samples collected for genotyping using a commercial genomic test. Based on genomic predicted transmitting ability values for daughter pregnancy rate (gDPR) cows were classified into a high (Hi-Fert; gDPR > 0...
April 18, 2024: Journal of Dairy Science
https://read.qxmd.com/read/38642646/a-randomized-controlled-trial-evaluating-the-efficacy-of-systemic-ceftiofur-administration-for-metritis-therapy-in-dairy-cows-and-the-effect-of-metritis-cure-on-economically-important-outcomes
#30
JOURNAL ARTICLE
P R Menta, L Fernandes, J Prim, E De Oliveira, F Lima, K N Galvão, N Noyes, M A Ballou, V S Machado
The main objective of this study was to evaluate the effect of ceftiofur on metritis cure, milk yield, reproductive performance, and culling up to 300 DIM. The secondary objective was to evaluate the effect of metritis cure at 5 (ECURE) and 14 (LCURE) d after diagnosis on milk production, reproduction, and culling. A total of 422 Holstein cows diagnosed with metritis from 4 herds located in TX, CA, and FL were enrolled in a randomized clinical trial. Cows diagnosed with metritis (fetid, watery, reddish/brownish uterine discharge) were blocked by herd and parity and were randomly allocated to receive systemic administration of ceftiofur (CEF) or to remain untreated (CON)...
April 18, 2024: Journal of Dairy Science
https://read.qxmd.com/read/38641750/an-autoantibody-signature-predictive-for-multiple-sclerosis
#31
JOURNAL ARTICLE
Colin R Zamecnik, Gavin M Sowa, Ahmed Abdelhak, Ravi Dandekar, Rebecca D Bair, Kristen J Wade, Christopher M Bartley, Kerry Kizer, Danillo G Augusto, Asritha Tubati, Refujia Gomez, Camille Fouassier, Chloe Gerungan, Colette M Caspar, Jessica Alexander, Anne E Wapniarski, Rita P Loudermilk, Erica L Eggers, Kelsey C Zorn, Kirtana Ananth, Nora Jabassini, Sabrina A Mann, Nicholas R Ragan, Adam Santaniello, Roland G Henry, Sergio E Baranzini, Scott S Zamvil, Joseph J Sabatino, Riley M Bove, Chu-Yueh Guo, Jeffrey M Gelfand, Richard Cuneo, H-Christian von Büdingen, Jorge R Oksenberg, Bruce A C Cree, Jill A Hollenbach, Ari J Green, Stephen L Hauser, Mitchell T Wallin, Joseph L DeRisi, Michael R Wilson
Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum Repository (DoDSR), a cohort of over 10 million individuals, was used to generate whole-proteome autoantibody profiles of hundreds of patients with MS (PwMS) years before and subsequently after MS onset. This analysis defines a unique cluster in approximately 10% of PwMS who share an autoantibody signature against a common motif that has similarity with many human pathogens...
April 19, 2024: Nature Medicine
https://read.qxmd.com/read/38641645/author-correction-new-genetic-signals-for-lung-function-highlight-pathways-and-chronic-obstructive-pulmonary-disease-associations-across-multiple-ancestries
#32
Nick Shrine, Anna L Guyatt, A Mesut Erzurumluoglu, Victoria E Jackson, Brian D Hobbs, Carl A Melbourne, Chiara Batini, Katherine A Fawcett, Kijoung Song, Phuwanat Sakornsakolpat, Xingnan Li, Ruth Boxall, Nicola F Reeve, Ma'en Obeidat, Jing Hua Zhao, Matthias Wielscher, Stefan Weiss, Katherine A Kentistou, James P Cook, Benjamin B Sun, Jian Zhou, Jennie Hui, Stefan Karrasch, Medea Imboden, Sarah E Harris, Jonathan Marten, Stefan Enroth, Shona M Kerr, Ida Surakka, Veronique Vitart, Terho Lehtimäki, Richard J Allen, Per S Bakke, Terri H Beaty, Eugene R Bleecker, Yohan Bossé, Corry-Anke Brandsma, Zhengming Chen, James D Crapo, John Danesh, Dawn L DeMeo, Frank Dudbridge, Ralf Ewert, Christian Gieger, Amund Gulsvik, Anna L Hansell, Ke Hao, Joshua D Hoffman, John E Hokanson, Georg Homuth, Peter K Joshi, Philippe Joubert, Claudia Langenberg, Xuan Li, Liming Li, Kuang Lin, Lars Lind, Nicholas Locantore, Jian'an Luan, Anubha Mahajan, Joseph C Maranville, Alison Murray, David C Nickle, Richard Packer, Margaret M Parker, Megan L Paynton, David J Porteous, Dmitry Prokopenko, Dandi Qiao, Rajesh Rawal, Heiko Runz, Ian Sayers, Don D Sin, Blair H Smith, María Soler Artigas, David Sparrow, Ruth Tal-Singer, Paul R H J Timmers, Maarten Van den Berge, John C Whittaker, Prescott G Woodruff, Laura M Yerges-Armstrong, Olga G Troyanskaya, Olli T Raitakari, Mika Kähönen, Ozren Polašek, Ulf Gyllensten, Igor Rudan, Ian J Deary, Nicole M Probst-Hensch, Holger Schulz, Alan L James, James F Wilson, Beate Stubbe, Eleftheria Zeggini, Marjo-Riitta Jarvelin, Nick Wareham, Edwin K Silverman, Caroline Hayward, Andrew P Morris, Adam S Butterworth, Robert A Scott, Robin G Walters, Deborah A Meyers, Michael H Cho, David P Strachan, Ian P Hall, Martin D Tobin, Louise V Wain
No abstract text is available yet for this article.
April 19, 2024: Nature Genetics
https://read.qxmd.com/read/38640782/multitissue-transcriptomics-demonstrates-the-systemic-physiology-of-methionine-deficiency-in-broiler-chickens
#33
JOURNAL ARTICLE
M Klünemann, L F Romero, M Acman, M C Milfort, A L Fuller, R Rekaya, S E Aggrey, L M Payling, A Lemme
Methionine (Met) supplementation is common practice in broilers to support nutrition, yet there are gaps in the understanding of its role in systemic physiology. Furthermore, several different Met sources are available that may have different physiological effects. This study evaluated the mode of action of Met deficiency (no Met-supplementation) and supplementation (0.25% DL- or L-Met, 0.41% liquid methionine hydroxy analog-free acid (MHA-FA)), and of Met source (DL-, L- or MHA-FA) in broiler chickens, via host transcriptomics...
March 25, 2024: Animal
https://read.qxmd.com/read/38640399/study-of-the-f_-0-980-and-f_-0-500-scalar-mesons-through-the-decay-d_-s-%C3%A2-%C3%AF-%C3%AF-e-%C3%AE-_-e
#34
JOURNAL ARTICLE
M Ablikim, M N Achasov, P Adlarson, R Aliberti, A Amoroso, M R An, Q An, Y Bai, O Bakina, I Balossino, Y Ban, V Batozskaya, K Begzsuren, N Berger, M Berlowski, M Bertani, D Bettoni, F Bianchi, E Bianco, J Bloms, A Bortone, I Boyko, R A Briere, A Brueggemann, H Cai, X Cai, A Calcaterra, G F Cao, N Cao, S A Cetin, J F Chang, T T Chang, W L Chang, G R Che, G Chelkov, C Chen, Chao Chen, G Chen, H S Chen, M L Chen, S J Chen, S M Chen, T Chen, X R Chen, X T Chen, Y B Chen, Y Q Chen, Z J Chen, W S Cheng, S K Choi, X Chu, G Cibinetto, S C Coen, F Cossio, J J Cui, H L Dai, J P Dai, A Dbeyssi, R E de Boer, D Dedovich, Z Y Deng, A Denig, I Denysenko, M Destefanis, F De Mori, B Ding, X X Ding, Y Ding, Y Ding, J Dong, L Y Dong, M Y Dong, X Dong, S X Du, Z H Duan, P Egorov, Y L Fan, J Fang, S S Fang, W X Fang, Y Fang, R Farinelli, L Fava, F Feldbauer, G Felici, C Q Feng, J H Feng, K Fischer, M Fritsch, C Fritzsch, C D Fu, J L Fu, Y W Fu, H Gao, Y N Gao, Yang Gao, S Garbolino, I Garzia, P T Ge, Z W Ge, C Geng, E M Gersabeck, A Gilman, K Goetzen, L Gong, W X Gong, W Gradl, S Gramigna, M Greco, M H Gu, Y T Gu, C Y Guan, Z L Guan, A Q Guo, L B Guo, R P Guo, Y P Guo, A Guskov, X T Hou, T T Han, W Y Han, X Q Hao, F A Harris, K K He, K L He, F H Heinsius, C H Heinz, Y K Heng, C Herold, T Holtmann, P C Hong, G Y Hou, Y R Hou, Z L Hou, H M Hu, J F Hu, T Hu, Y Hu, G S Huang, K X Huang, L Q Huang, X T Huang, Y P Huang, T Hussain, N Hüsken, W Imoehl, M Irshad, J Jackson, S Jaeger, S Janchiv, J H Jeong, Q Ji, Q P Ji, X B Ji, X L Ji, Y Y Ji, Z K Jia, P C Jiang, S S Jiang, T J Jiang, X S Jiang, Y Jiang, J B Jiao, Z Jiao, S Jin, Y Jin, M Q Jing, T Johansson, X Kui, S Kabana, N Kalantar-Nayestanaki, X L Kang, X S Kang, R Kappert, M Kavatsyuk, B C Ke, A Khoukaz, R Kiuchi, R Kliemt, L Koch, O B Kolcu, B Kopf, M K Kuessner, A Kupsc, W Kühn, J J Lane, J S Lange, P Larin, A Lavania, L Lavezzi, T T Lei, Z H Lei, H Leithoff, M Lellmann, T Lenz, C Li, C Li, C H Li, Cheng Li, D M Li, F Li, G Li, H Li, H B Li, H J Li, H N Li, Hui Li, J R Li, J S Li, J W Li, Ke Li, L J Li, L K Li, Lei Li, M H Li, P R Li, S X Li, T Li, W D Li, W G Li, X H Li, X L Li, Xiaoyu Li, Y G Li, Z J Li, Z X Li, Z Y Li, C Liang, H Liang, H Liang, H Liang, Y F Liang, Y T Liang, G R Liao, L Z Liao, J Libby, A Limphirat, D X Lin, T Lin, B J Liu, B X Liu, C Liu, C X Liu, D Liu, F H Liu, Fang Liu, Feng Liu, G M Liu, H Liu, H B Liu, H M Liu, Huanhuan Liu, Huihui Liu, J B Liu, J L Liu, J Y Liu, K Liu, K Y Liu, Ke Liu, L Liu, L C Liu, Lu Liu, M H Liu, P L Liu, Q Liu, S B Liu, T Liu, W K Liu, W M Liu, X Liu, Y Liu, Y B Liu, Z A Liu, Z Q Liu, X C Lou, F X Lu, H J Lu, J G Lu, X L Lu, Y Lu, Y P Lu, Z H Lu, C L Luo, M X Luo, T Luo, X L Luo, X R Lyu, Y F Lyu, F C Ma, H L Ma, J L Ma, L L Ma, M M Ma, Q M Ma, R Q Ma, R T Ma, X Y Ma, Y Ma, Y M Ma, F E Maas, M Maggiora, S Maldaner, S Malde, A Mangoni, Y J Mao, Z P Mao, S Marcello, Z X Meng, J G Messchendorp, G Mezzadri, H Miao, T J Min, R E Mitchell, X H Mo, N Yu Muchnoi, Y Nefedov, F Nerling, I B Nikolaev, Z Ning, S Nisar, Y Niu, S L Olsen, Q Ouyang, S Pacetti, X Pan, Y Pan, A Pathak, P Patteri, Y P Pei, M Pelizaeus, H P Peng, K Peters, J L Ping, R G Ping, S Plura, S Pogodin, V Prasad, F Z Qi, H Qi, H R Qi, M Qi, T Y Qi, S Qian, W B Qian, C F Qiao, J J Qin, L Q Qin, X P Qin, X S Qin, Z H Qin, J F Qiu, S Q Qu, C F Redmer, K J Ren, A Rivetti, V Rodin, M Rolo, G Rong, Ch Rosner, S N Ruan, N Salone, A Sarantsev, Y Schelhaas, K Schoenning, M Scodeggio, K Y Shan, W Shan, X Y Shan, J F Shangguan, L G Shao, M Shao, C P Shen, H F Shen, W H Shen, X Y Shen, B A Shi, H C Shi, J L Shi, J Y Shi, Q Q Shi, R S Shi, X Shi, J J Song, T Z Song, W M Song, Y J Song, Y X Song, S Sosio, S Spataro, F Stieler, Y J Su, G B Sun, G X Sun, H Sun, H K Sun, J F Sun, K Sun, L Sun, S S Sun, T Sun, W Y Sun, Y Sun, Y J Sun, Y Z Sun, Z T Sun, Y X Tan, C J Tang, G Y Tang, J Tang, Y A Tang, L Y Tao, Q T Tao, M Tat, J X Teng, V Thoren, W H Tian, W H Tian, Y Tian, Z F Tian, I Uman, B Wang, B L Wang, Bo Wang, C W Wang, D Y Wang, F Wang, H J Wang, H P Wang, K Wang, L L Wang, M Wang, Meng Wang, S Wang, S Wang, T Wang, T J Wang, W Wang, W Wang, W H Wang, W P Wang, X Wang, X F Wang, X J Wang, X L Wang, Y Wang, Y D Wang, Y F Wang, Y H Wang, Y N Wang, Y Q Wang, Yaqian Wang, Yi Wang, Z Wang, Z L Wang, Z Y Wang, Ziyi Wang, D Wei, D H Wei, F Weidner, S P Wen, C W Wenzel, U W Wiedner, G Wilkinson, M Wolke, L Wollenberg, C Wu, J F Wu, L H Wu, L J Wu, X Wu, X H Wu, Y Wu, Y J Wu, Z Wu, L Xia, X M Xian, T Xiang, D Xiao, G Y Xiao, H Xiao, S Y Xiao, Y L Xiao, Z J Xiao, C Xie, X H Xie, Y Xie, Y G Xie, Y H Xie, Z P Xie, T Y Xing, C F Xu, C J Xu, G F Xu, H Y Xu, Q J Xu, Q N Xu, W Xu, W L Xu, X P Xu, Y C Xu, Z P Xu, Z S Xu, F Yan, L Yan, W B Yan, W C Yan, X Q Yan, H J Yang, H L Yang, H X Yang, Tao Yang, Y Yang, Y F Yang, Y X Yang, Yifan Yang, Z W Yang, M Ye, M H Ye, J H Yin, Z Y You, B X Yu, C X Yu, G Yu, J S Yu, T Yu, X D Yu, C Z Yuan, L Yuan, S C Yuan, X Q Yuan, Y Yuan, Z Y Yuan, C X Yue, A A Zafar, F R Zeng, X Zeng, Y Zeng, Y J Zeng, X Y Zhai, Y H Zhan, A Q Zhang, B L Zhang, B X Zhang, D H Zhang, G Y Zhang, H Zhang, H H Zhang, H H Zhang, H Q Zhang, H Y Zhang, J J Zhang, J L Zhang, J Q Zhang, J W Zhang, J X Zhang, J Y Zhang, J Z Zhang, Jianyu Zhang, Jiawei Zhang, L M Zhang, L Q Zhang, Lei Zhang, P Zhang, Q Y Zhang, Shuihan Zhang, Shulei Zhang, X D Zhang, X M Zhang, X Y Zhang, X Y Zhang, Y Zhang, Y Zhang, Y T Zhang, Y H Zhang, Yan Zhang, Yao Zhang, Z H Zhang, Z L Zhang, Z Y Zhang, Z Y Zhang, G Zhao, J Zhao, J Y Zhao, J Z Zhao, Lei Zhao, Ling Zhao, M G Zhao, S J Zhao, Y B Zhao, Y X Zhao, Z G Zhao, A Zhemchugov, B Zheng, J P Zheng, W J Zheng, Y H Zheng, B Zhong, X Zhong, H Zhou, L P Zhou, X Zhou, X K Zhou, X R Zhou, X Y Zhou, Y Z Zhou, J Zhu, K Zhu, K J Zhu, L Zhu, L X Zhu, S H Zhu, S Q Zhu, T J Zhu, W J Zhu, Y C Zhu, Z A Zhu, J H Zou, J Zu
Using e^{+}e^{-} collision data corresponding to an integrated luminosity of 7.33  fb^{-1} recorded by the BESIII detector at center-of-mass energies between 4.128 and 4.226 GeV, we present an analysis of the decay D_{s}^{+}→π^{+}π^{-}e^{+}ν_{e}, where the D_{s}^{+} is produced via the process e^{+}e^{-}→D_{s}^{*±}D_{s}^{∓}. We observe the f_{0}(980) in the π^{+}π^{-} system and the branching fraction of the decay D_{s}^{+}→f_{0}(980)e^{+}ν_{e} with f_{0}(980)→π^{+}π^{-} measured to be (1...
April 5, 2024: Physical Review Letters
https://read.qxmd.com/read/38640252/gut-associated-lymphoid-tissue-attrition-associates-with-response-to-anti-%C3%AE-4%C3%AE-7-therapy-in-ulcerative-colitis
#35
JOURNAL ARTICLE
Pablo Canales-Herrerias, Mathieu Uzzan, Akihiro Seki, Rafael S Czepielewski, Bram Verstockt, Alexandra E Livanos, Fiona Raso, Alexandra Dunn, Daniel Dai, Andrew Wang, Zainab Al-Taie, Jerome Martin, Thomas Laurent, Huaibin M Ko, Minami Tokuyama, Michael Tankelevich, Hadar Meringer, Francesca Cossarini, Divya Jha, Azra Krek, John D Paulsen, Matthew D Taylor, Mohammad Zuber Nakadar, Joshua Wong, Emma C Erlich, Rachel L Mintz, Emily J Onufer, Beth A Helmink, Keshav Sharma, Adam Rosenstein, Danielle Ganjian, Grace Chung, Travis Dawson, Julius Juarez, Vijay Yajnik, Andrea Cerutti, Jeremiah J Faith, Mayte Suarez-Farinas, Carmen Argmann, Francesca Petralia, Gwendalyn J Randolph, Alexandros D Polydorides, Andrea Reboldi, Jean-Frederic Colombel, Saurabh Mehandru
Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7- mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine the mechanisms of action of VDZ, we examined five distinct cohorts of patients with UC. A decrease in naïve B and T cells in the intestines and gut-homing (β7+ ) plasmablasts in circulation of VDZ-treated patients suggested that VDZ targets gut-associated lymphoid tissue (GALT). Anti-α4β7 blockade in wild-type and photoconvertible (KikGR) mice confirmed a loss of GALT size and cellularity because of impaired cellular entry...
April 19, 2024: Science Immunology
https://read.qxmd.com/read/38639993/-staphylococcus-aureus-ftsz-and-pbp4-bind-to-the-conformationally-dynamic-n-terminal-domain-of-gpsb
#36
JOURNAL ARTICLE
Michael D Sacco, Lauren R Hammond, Radwan E Noor, Dipanwita Bhattacharya, Lily J McKnight, Jesper J Madsen, Xiujun Zhang, Shane G Butler, M Trent Kemp, Aiden C Jaskolka-Brown, Sebastian J Khan, Ioannis Gelis, Prahathees Eswara, Yu Chen
In the Firmicutes phylum, GpsB is a membrane associated protein that coordinates peptidoglycan synthesis with cell growth and division. Although GpsB has been studied in several bacteria, the structure, function, and interactome of Staphylococcus aureus GpsB is largely uncharacterized. To address this knowledge gap, we solved the crystal structure of the N-terminal domain of S. aureus GpsB, which adopts an atypical, asymmetric dimer, and demonstrates major conformational flexibility that can be mapped to a hinge region formed by a three-residue insertion exclusive to Staphylococci ...
April 19, 2024: ELife
https://read.qxmd.com/read/38639530/proposal-of-model-for-personalized-early-adapted-cancer-screening-in-people-living-with-hiv-experience-of-gaetano-martino-hospital-university-of-messina
#37
JOURNAL ARTICLE
G F Pellicanò, A Squeri, G Ciappina, R Squeri, V I Palmara, S Parisi, I Campo, C Saitta, M Rossanese, E Di Trapani, S Mancuso, N Catalano, A Allegra, G Mancuso, G Murolo, A Bignucolo, D A Restivo, P Consolo, M Berretta
Human immunodeficiency virus (HIV) infection has historically been related to the development of specific cancers, some of which are so closely linked to the infection, such as Kaposi's Sarcoma (KS), that they have earned the name Acquired Immuno-Deficiency Syndrome (AIDS)-defining cancers (ADCs). While the development of antiretroviral therapy (ART) has decreased the incidence of AIDS-defining cancers, the resulting aging of people living with HIV (PLWH) highlighted an increased occurrence of other forms of cancer...
April 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38638695/expanded-expression-of-pro-neurogenic-factor-soxb1-during-larval-development-of-gastropod-lymnaea-stagnalis-suggests-preadaptation-to-prolonged-neurogenesis-in-mollusca
#38
JOURNAL ARTICLE
Anastasia I Kurtova, Alexander D Finoshin, Margarita S Aparina, Guzel R Gazizova, Olga S Kozlova, Svetlana N Voronova, Elena I Shagimardanova, Evgeny G Ivashkin, Elena E Voronezhskaya
INTRODUCTION: The remarkable diversity observed in the structure and development of the molluscan nervous system raises intriguing questions regarding the molecular mechanisms underlying neurogenesis in Mollusca . The expression of SoxB family transcription factors plays a pivotal role in neuronal development, thereby offering valuable insights into the strategies of neurogenesis. METHODS: In this study, we conducted gene expression analysis focusing on SoxB-family transcription factors during early neurogenesis in the gastropod Lymnaea stagnalis ...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38638658/topical-application-of-vancomycin-powder-to-prevent-infections-after-massive-bone-resection-and-the-implantation-of-megaprostheses-in-orthopaedic-oncology-surgery
#39
JOURNAL ARTICLE
L Andreani, E Ipponi, G Varchetta, A D Ruinato, S De-Franco, F R Campo, A D'Arienzo
INTRODUCTION: Periprosthetic joint infection (PJI) represents a serious burden in orthopaedic oncology. Through the years, several local expedients have been proposed to minimise the risk of periprosthetic infection. In this study, we report our outcomes using topical vancomycin powder (VP) with the aim to prevent PJIs. MATERIALS AND METHODS: Fifty oncological cases treated with massive bone resection and the implant of a megaprosthesis were included in our study...
March 2024: Malaysian Orthopaedic Journal
https://read.qxmd.com/read/38638162/hi1a-improves-sensorimotor-deficit-following-endothelin-1-induced-stroke-in-rats-but-does-not-improve-functional-outcomes-following-filament-induced-stroke-in-mice
#40
JOURNAL ARTICLE
Adriana Knezic, Elena Budusan, Natalie J Saez, Brad R S Broughton, Lachlan D Rash, Glenn F King, Robert E Widdop, Claudia A McCarthy
Activation of acid-sensing ion channel 1a (ASIC1a) plays a major role in mediating acidosis-induced neuronal injury following a stroke. Therefore, the inhibition of ASIC1a is a potential therapeutic avenue for the treatment of stroke. Venom-peptide Hi1a, a selective and highly potent ASIC1a inhibitor, reduces the infarct size and functional deficits when injected into the brain after stroke in rodents. However, its efficacy when administered using a clinically relevant route of administration remains to be established...
April 12, 2024: ACS Pharmacology & Translational Science
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