Seong Eun Lee, Bon Seok Koo, Pureum Sun, Shinae Yi, Na Rae Choi, Jiyeon Yoon, Seon-Young Kim, Seon-Kyu Kim, Seongyeol Park, Aliya Lakhani, Samantha O'Keeffe, Junyoung O Park, Da Hyun Kang, Yea Eun Kang
Neutrophil heterogeneity is involved in autoimmune diseases, sepsis, and several cancers. However, the link between neutrophil heterogeneity and T-cell immunity in thyroid cancer is incompletely understood. We investigated the circulating neutrophil heterogeneity in 3 undifferentiated thyroid cancer (UTC), 14 differentiated thyroid cancer (DTC) (4 Stage IV, 10 Stage I-II), and healthy controls (n = 10) by transcriptomic data and cytometry. Participants with UTC had a significantly higher proportion of immature high-density neutrophils (HDN) and lower proportion of mature HDN in peripheral blood compared to DTC...
May 8, 2024: Cell Death Discovery