keyword
https://read.qxmd.com/read/37725913/racial-disparities-in-end-stage-kidney-disease-outcomes-among-asians-and-native-hawaiians-and-other-pacific-islanders-across-geographic-residence
#1
JOURNAL ARTICLE
Amy S You, Keith C Norris, Merle Kataoka-Yahiro, James Davis, Victoria Page, Glen Hayashida, Yoko Narasaki, Shiuh Feng Cheng, Roland Ng, Linda L Wong, Felix Lee, Kamyar Kalantar-Zadeh, Connie M Rhee
INTRODUCTION: While Asians and Native Hawaiian and other Pacific Islanders (NHOPIs) have a high prevalence of kidney disease risk factors, there are sparse data examining their end-stage kidney disease (ESKD) outcomes. As Hawaii has high representation of Asians and NHOPIs, we compared their ESKD outcomes based on residence in the Mainland US vs. Hawaii/Pacific Islands (PIs). MATERIALS AND METHODS: Using United States Renal Data System data, we examined the impact of geographic residence in the Mainland vs...
September 19, 2023: American Journal of Nephrology
https://read.qxmd.com/read/37035453/hepatocellular-carcinoma-in-pacific-islanders-comparison-of-pacific-island-born-vs-us-born
#2
JOURNAL ARTICLE
Shelby K Yee, Brenda Y Hernandez, Sandi Kwee, Linda L Wong
AIM: To describe demographic, clinical, and outcome differences in Pacific Island-born (PI-born) compared to US-born hepatocellular carcinoma (HCC) patients of Pacific Island ancestry within a clinical cohort in Hawaii. METHODS: A prospectively collected database of 1608 patients diagnosed with HCC over a 30-year period (1993-2022) identified 252 patients of Pacific Islander ethnicity. Data collected: demographics, medical history, laboratory data, tumor characteristics, treatment, and survival...
2023: Hepatoma Research
https://read.qxmd.com/read/36877257/symbiotic-nitrogen-fixation-does-not-stimulate-soil-phosphatase-activity-under-temperate-and-tropical-trees
#3
JOURNAL ARTICLE
Emily A Jager, Andrew W Quebbeman, Amelia A Wolf, Steven S Perakis, Jennifer L Funk, Duncan N L Menge
Symbiotic nitrogen (N)-fixing plants can enrich ecosystems with N, which can alter the cycling and demand for other nutrients. Researchers have hypothesized that fixed N could be used by plants and soil microbes to produce extracellular phosphatase enzymes, which release P from organic matter. Consistent with this speculation, the presence of N-fixing plants is often associated with high phosphatase activity, either in the soil or on root surfaces, although other studies have not found this association, and the connection between phosphatase and rates of N fixation-the mechanistic part of the argument-is tenuous...
March 6, 2023: Oecologia
https://read.qxmd.com/read/34786570/impact-of-coronavirus-2019-on-pediatric-and-adult-heart-transplantation-waitlist-activity-and-mortality-in-the-united-states-a-descriptive-approach
#4
JOURNAL ARTICLE
Awais Ashfaq, Geoffrey M Gray, Jennifer Carapellucci, Ernest K Amankwah, Luis M Ahumada, Mohamed Rehman, Michael Puchalski, Andrew Smith, James A Quintessenza, Alfred Asante-Korang
Background: Transplant centers saw a substantial reduction in deceased donor solid organ transplantation since the beginning of the coronavirus 2019 (COVID-19) pandemic in the United States. There is limited data on the impact of COVID-19 on adult and pediatric heart transplant volume and variation in transplant practices. We hypothesized that heart transplant activity decreased during COVID-19 with associated increased waitlist mortality. Methods: The United Network for Organ Sharing (UNOS) database was used to identify patients at the time of listing for heart transplant from 2017-2020...
November 2021: Lancet Reg Health Am
https://read.qxmd.com/read/34447820/increased-morbidity-and-mortality-of-hepatocellular-carcinoma-patients-in-lower-cost-of-living-areas
#5
JOURNAL ARTICLE
Tomoki Sempokuya, Kishan P Patel, Muaataz Azawi, Jihyun Ma, Linda L Wong
BACKGROUND: The incidence and mortality rates of hepatocellular carcinoma (HCC) are increasing in the United States. However, the increases in different racial and socioeconomic groups have not been homogeneous. Access to healthcare based on socioeconomic status and cost of living index (COLI), especially in HCC management, is under characterized. AIM: The aim was to investigate the relationship between the COLI and tumor characteristics, treatment modalities, and survival of HCC patients in the United States...
August 16, 2021: World Journal of Clinical Cases
https://read.qxmd.com/read/34056079/geographic-distribution-of-cytomegalovirus-serology-in-kidney-and-pancreas-transplant-recipients-in-the-united-states
#6
JOURNAL ARTICLE
Margaret R Jorgenson, Sandesh Parajuli, Nicholas Marka, Glen E Leverson, Jeannina A Smith, Didier A Mandelbrot, Jon S Odorico
Backgrounds: Cytomegalovirus (CMV) negatively affects transplant outcomes. The current geographic distribution of CMV risk within the US has not been described. Methods: CMV serostatus of donors and recipients in each US state were collected from the Scientific Registry of Transplant Recipients between April 1, 2015, and March 31, 2019. The objective was to describe rates of CMV recipient seropositivity (R+) and high-risk serostatus (D+/R-) across the US in kidney transplant recipient (KTR) and pancreas transplant recipient (PTR) and explore geographic disparities...
June 2021: Transplantation Direct
https://read.qxmd.com/read/33860266/effects-of-fluopyram-and-azadirachtin-integration-with-sunn-hemp-on-nematode-communities-in-zucchini-tomato-and-sweet-potato-in-hawaii
#7
JOURNAL ARTICLE
Philip Waisen, Koon-Hui Wang, Jensen Uyeda, Roxana Y Myers
Fluopyram (Velum® One) is a synthetic nematicide and azadirachtin (Molt-X® ) is a biological nematicide. Both have shown promise against plant-parasitic nematodes on several agriculturally important crops. There is a lack of information on integration of pre-plant sunn hemp ( Crotalaria juncea ) cover crop with these post-plant nematicides, aiming to improve plant-parasitic nematodes management and mitigate any detrimental effects on free-living nematodes. Three field trials were conducted to investigate the effects of fluopyram alone or in combination with pre-plant sunn hemp cover crop, and azadirachtin combined with pre-plant sunn hemp on Rotylenchulus reniformis and Meloidogyne spp...
2021: Journal of Nematology
https://read.qxmd.com/read/33675176/expanding-donor-availability-in-lung-transplantation-a-case-report-of-5-000-miles-traveled
#8
Zachary W Fitch, Julie Doberne, John M Reynolds, Ian Jamieson, John C Haney, Jacob A Klapper, Matthew G Hartwig
We present the case of a 41-year-old female who underwent bilateral lung transplantation after the donor lungs were placed on a normothermic ex-vivo lung perfusion and ventilation device and flown nearly 5,000 miles from Honolulu, Hawaii to Durham, North Carolina. The patient experienced no primary graft dysfunction. One year after transplantation she has remained rejection-free and exhibits excellent pulmonary function. This case highlights the challenge that active organ preservation systems pose to questions of organ allocation and geographic sharing...
March 6, 2021: American Journal of Transplantation
https://read.qxmd.com/read/33564085/physiological-and-molecular-responses-of-lobe-coral-indicate-nearshore-adaptations-to-anthropogenic-stressors
#9
JOURNAL ARTICLE
Kaho H Tisthammer, Emma Timmins-Schiffman, Francois O Seneca, Brook L Nunn, Robert H Richmond
Corals in nearshore marine environments are increasingly exposed to reduced water quality, which is the primary local threat to Hawaiian coral reefs. It is unclear if corals surviving in such conditions have adapted to withstand sedimentation, pollutants, and other environmental stressors. Lobe coral populations from Maunalua Bay, Hawaii showed clear genetic differentiation between the 'polluted, high-stress' nearshore site and the 'less polluted, lower-stress' offshore site. To understand the driving force of the observed genetic partitioning, reciprocal transplant and common-garden experiments were conducted to assess phenotypic differences between these two populations...
February 9, 2021: Scientific Reports
https://read.qxmd.com/read/32849735/alteration-of-bacterial-wilt-resistance-in-tomato-plant-by-microbiota-transplant
#10
JOURNAL ARTICLE
Kihyuck Choi, Jinhee Choi, Pyeong An Lee, Nazish Roy, Raees Khan, Hyoung Ju Lee, Hang Yeon Weon, Hyun Gi Kong, Seon-Woo Lee
Plant-associated microbiota plays an important role in plant disease resistance. Bacterial wilt resistance of tomato is a function of the quantitative trait of tomato plants; however, the mechanism underlying quantitative resistance is unexplored. In this study, we hypothesized that rhizosphere microbiota affects the resistance of tomato plants against soil-borne bacterial wilt caused by Ralstonia solanacearum . This hypothesis was tested using a tomato cultivar grown in a defined soil with various microbiota transplants...
2020: Frontiers in Plant Science
https://read.qxmd.com/read/31381199/should-a-homeless-person-become-a-deceased-organ-donor
#11
JOURNAL ARTICLE
William G Lee, Linda L Wong, Roderick Olivas, Ailea Apana, Katharine Kickertz, Makoto Ogihara
Efforts to increase deceased donation have included the use of US Public Health Service (PHS) high-risk donors. The homeless have high rates of medical and substance abuse issues that are often unrecognized. This study investigates whether the homeless should become suitable organ donors. We retrospectively reviewed 193 brain-dead prospective donors from Hawaii's organ procurement organization (OPO; 2013-2018) and compared two groups: homeless (n = 13) and non-homeless (n = 180) prospective donors. The homeless prospective donors were older (48...
October 2019: Clinical Transplantation
https://read.qxmd.com/read/31260552/a-clinical-study-on-cadaveric-kidney-donors-in-puerto-rico-and-the-survival-outcome-of-the-grafts-a-retrospective-study-of-187-kidneys-from-2009-2011
#12
JOURNAL ARTICLE
Eduardo Michelen-Gómez, Rafael Ramos, Juan Ruiz, Luis Morales, Marien Saade, Esther A Torres
OBJECTIVE: In this study, we assessed the Kidney Donor Risk Index (KDRI) in Puerto Rican deceased kidney donors whose donations took place from 2009 to 2011 and evaluated short-term graft survival in the recipients of those kidneys. The results highlight differences between the distributions of KDRI values in the populations of the 48 contiguous states of the United States, Alaska, and Hawaii and that of Puerto Rico. Additionally, we evaluated the impacts of polyomavirus (BKV) infection and anti-donor HLA antibodies on the recipients...
June 2019: Puerto Rico Health Sciences Journal
https://read.qxmd.com/read/30295674/rhizosphere-microbiome-structure-alters-to-enable-wilt-resistance-in-tomato
#13
JOURNAL ARTICLE
Min-Jung Kwak, Hyun Gi Kong, Kihyuck Choi, Soon-Kyeong Kwon, Ju Yeon Song, Jidam Lee, Pyeong An Lee, Soo Yeon Choi, Minseok Seo, Hyoung Ju Lee, Eun Joo Jung, Hyein Park, Nazish Roy, Heebal Kim, Myeong Min Lee, Edward M Rubin, Seon-Woo Lee, Jihyun F Kim
Tomato variety Hawaii 7996 is resistant to the soil-borne pathogen Ralstonia solanacearum, whereas the Moneymaker variety is susceptible to the pathogen. To evaluate whether plant-associated microorganisms have a role in disease resistance, we analyzed the rhizosphere microbiomes of both varieties in a mesocosm experiment. Microbiome structures differed between the two cultivars. Transplantation of rhizosphere microbiota from resistant plants suppressed disease symptoms in susceptible plants. Comparative analyses of rhizosphere metagenomes from resistant and susceptible plants enabled the identification and assembly of a flavobacterial genome that was far more abundant in the resistant plant rhizosphere microbiome than in that of the susceptible plant...
October 8, 2018: Nature Biotechnology
https://read.qxmd.com/read/30079276/hepatocellular-carcinoma-in-micronesians-a-growing-pacific-islander-population-in-the-u-s
#14
JOURNAL ARTICLE
Eric M Wu, Brenda Y Hernandez, Linda L Wong
Aim: Micronesians are a rapidly growing population in Hawaii and the continental U.S. Hepatitis B is prevalent in Micronesia, but the consequences in those migrating to the U.S. are unclear. This study characterizes hepatocellular carcinoma in Micronesians with comparisons to other Pacific Islanders. Methods: A retrospective evaluation was undertaken of 40 Micronesian and 142 Non-Micronesian Pacific hepatocellular carcinoma patients diagnosed in a large clinical practice in Hawaii from 1993-2017...
2018: Open Journal of Gastroenterology
https://read.qxmd.com/read/28219592/urgent-liver-transplantation-for-dietary-supplements-an-under-recognized-problem
#15
MULTICENTER STUDY
L L Wong, L Lacar, M Roytman, S L Orloff
BACKGROUND: The recent outbreak of acute liver failure caused by herbal/dietary supplements (HDS) in Hawaii prompted evaluation of those patients who underwent emergency liver transplantation (LT) for HDS in the United States. METHODS: We queried the Scientific Registry of Transplant Recipients (2003-2015) to identify patients who underwent urgent LT for acute hepatic necrosis (AHN) and identified those with HDS use. This group of patients was then characterized...
March 2017: Transplantation Proceedings
https://read.qxmd.com/read/27367536/hepatotoxicity-associated-with-weight-loss-or-sports-dietary-supplements-including-oxyelite-pro%C3%A2-united-states-2013
#16
JOURNAL ARTICLE
Kevin Chatham-Stephens, Ethel Taylor, Arthur Chang, Amy Peterson, Johnni Daniel, Colleen Martin, Patricia Deuster, Rebecca Noe, Stephanie Kieszak, Josh Schier, Karl Klontz, Lauren Lewis
In September 2013, the Hawaii Department of Health (HDOH) was notified of seven adults who developed acute hepatitis after taking OxyELITE Pro™, a weight loss and sports dietary supplement. CDC assisted HDOH with their investigation, then conducted case-finding outside of Hawaii with FDA and the Department of Defense (DoD). We defined cases as acute hepatitis of unknown etiology that occurred from April 1, 2013, through December 5, 2013, following exposure to a weight loss or muscle-building dietary supplement, such as OxyELITE Pro™...
January 2017: Drug Testing and Analysis
https://read.qxmd.com/read/27026431/examining-the-clinical-course-of-genotype-1-chronic-hepatitis-c-patients-treated-with-the-cosmos-regimen-including-patients-with-advanced-liver-disease-and-east-asian-ancestry
#17
JOURNAL ARTICLE
Marina Roytman, Resham Ramkissoon, Christina Wu, Leena Hong, Ruby Trujillo, Leslie Huddleston, Peter Poerzgen, Todd Seto, Linda Wong, Naoky Tsai
BACKGROUND/OBJECTIVES: The COSMOS study was a phase 2a clinical trial that showed high cure rates of genotype 1 chronic hepatitis C (CHC) and a favorable side effect profile using a 12-week regimen of simeprevir + sofosbuvir (SIM + SOF). Given the small number of patients treated with the SIM + SOF regimen in the COSMOS trial, there is uncertainty regarding the efficacy and safety of this combination therapy. We now report our experience with the COSMOS regimen in the multiethnic population of Hawaii, including patients of East Asian ancestry and with decompensated cirrhosis...
July 2016: Hepatology International
https://read.qxmd.com/read/26538199/hepatotoxicity-associated-with-the-dietary-supplement-oxyelite-pro%C3%A2-hawaii-2013
#18
JOURNAL ARTICLE
David I Johnston, Arthur Chang, Melissa Viray, Kevin Chatham-Stephens, Hua He, Ethel Taylor, Linda L Wong, Joshua Schier, Colleen Martin, Daniel Fabricant, Monique Salter, Lauren Lewis, Sarah Y Park
Dietary supplements are increasingly marketed to and consumed by the American public for a variety of purported health benefits. On 9 September 2013, the Hawaii Department of Health (HDOH) was notified of a cluster of acute hepatitis and fulminant hepatic failure among individuals with exposure to the dietary supplement OxyELITE Pro™ (OEP). HDOH conducted an outbreak investigation in collaboration with federal partners. Physicians were asked to report cases, defined as individuals with acute onset hepatitis of unknown etiology on or after 1 April 2013, a history of weight-loss/muscle-building dietary supplement use during the 60 days before illness onset, and residence in Hawaii during the period of exposure...
March 2016: Drug Testing and Analysis
https://read.qxmd.com/read/26327730/the-role-of-adverse-event-reporting-in-the-fda-response-to-a-multistate-outbreak-of-liver-disease-associated-with-a-dietary-supplement
#19
JOURNAL ARTICLE
Karl C Klontz, Heidi J DeBeck, Pamela LeBlanc, Kathryn M Mogen, Beverly J Wolpert, Jonathan L Sabo, Monique Salter, Sharon L Seelman, Susan E Lance, Caitlin Monahan, David S Steigman, Kathleen Gensheimer
OBJECTIVE: Liver disease is a potential complication from using dietary supplements. This study investigated an outbreak of non-viral liver disease associated with the use of OxyELITE Pro(TM), a dietary supplement used for weight loss and/or muscle building. METHODS: Illness details were ascertained from MedWatch reports submitted to the U.S. Food and Drug Administration (FDA) describing consumers who ingested OxyELITE Pro alone or in combination with other dietary supplements...
September 2015: Public Health Reports
https://read.qxmd.com/read/25510478/the-changing-characteristics-of-hepatocellular-cancer-in-hawaii-over-time
#20
JOURNAL ARTICLE
Linda L Wong, Makoto Ogihara, Junfang Ji, Naoky Tsai
BACKGROUND: The incidence of hepatocellular cancer (HCC) is increasing, and we sought to characterize the differences and trends in HCC over 2 decades in Hawaii. METHODS: This retrospective study of 821 HCC cases analyzed risk factors, diabetes, alpha-fetoprotein (AFP), tumor characteristics, and treatment, comparing 5-year eras (1993 to 2012). RESULTS: With succeeding eras, there were fewer Asians, immigrants, and hepatitis B-related HCC...
July 2015: American Journal of Surgery
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