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https://www.readbyqxmd.com/read/27367536/hepatotoxicity-associated-with-weight-loss-or-sports-dietary-supplements-including-oxyelite-pro%C3%A2-united-states-2013
#1
Kevin Chatham-Stephens, Ethel Taylor, Art Chang, Amy Peterson, Johnni Daniel, Colleen Martin, Patricia Deuster, Rebecca Noe, Stephanie Kieszak, Josh Schier, Karl Klontz, Lauren Lewis
In September 2013, the Hawaii Department of Health (HDOH) was notified of seven adults who developed acute hepatitis after taking OxyELITE Pro™, a weight loss and sports dietary supplement. CDC assisted HDOH with their investigation, then conducted case-finding outside of Hawaii with FDA and the Department of Defense (DoD). We defined cases as acute hepatitis of unknown etiology that occurred from April 1, 2013, through December 5, 2013, following exposure to a weight loss or muscle-building dietary supplement, such as OxyELITE Pro™...
July 1, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27026431/examining-the-clinical-course-of-genotype-1-chronic-hepatitis-c-patients-treated-with-the-cosmos-regimen-including-patients-with-advanced-liver-disease-and-east-asian-ancestry
#2
Marina Roytman, Resham Ramkissoon, Christina Wu, Leena Hong, Ruby Trujillo, Leslie Huddleston, Peter Poerzgen, Todd Seto, Linda Wong, Naoky Tsai
BACKGROUND/OBJECTIVES: The COSMOS study was a phase 2a clinical trial that showed high cure rates of genotype 1 chronic hepatitis C (CHC) and a favorable side effect profile using a 12-week regimen of simeprevir + sofosbuvir (SIM + SOF). Given the small number of patients treated with the SIM + SOF regimen in the COSMOS trial, there is uncertainty regarding the efficacy and safety of this combination therapy. We now report our experience with the COSMOS regimen in the multiethnic population of Hawaii, including patients of East Asian ancestry and with decompensated cirrhosis...
July 2016: Hepatology International
https://www.readbyqxmd.com/read/26538199/hepatotoxicity-associated-with-the-dietary-supplement-oxyelite-pro%C3%A2-hawaii-2013
#3
David I Johnston, Arthur Chang, Melissa Viray, Kevin Chatham-Stephens, Hua He, Ethel Taylor, Linda L Wong, Joshua Schier, Colleen Martin, Daniel Fabricant, Monique Salter, Lauren Lewis, Sarah Y Park
Dietary supplements are increasingly marketed to and consumed by the American public for a variety of purported health benefits. On 9 September 2013, the Hawaii Department of Health (HDOH) was notified of a cluster of acute hepatitis and fulminant hepatic failure among individuals with exposure to the dietary supplement OxyELITE Pro™ (OEP). HDOH conducted an outbreak investigation in collaboration with federal partners. Physicians were asked to report cases, defined as individuals with acute onset hepatitis of unknown etiology on or after 1 April 2013, a history of weight-loss/muscle-building dietary supplement use during the 60 days before illness onset, and residence in Hawaii during the period of exposure...
March 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/26327730/the-role-of-adverse-event-reporting-in-the-fda-response-to-a-multistate-outbreak-of-liver-disease-associated-with-a-dietary-supplement
#4
Karl C Klontz, Heidi J DeBeck, Pamela LeBlanc, Kathryn M Mogen, Beverly J Wolpert, Jonathan L Sabo, Monique Salter, Sharon L Seelman, Susan E Lance, Caitlin Monahan, David S Steigman, Kathleen Gensheimer
OBJECTIVE: Liver disease is a potential complication from using dietary supplements. This study investigated an outbreak of non-viral liver disease associated with the use of OxyELITE Pro(TM), a dietary supplement used for weight loss and/or muscle building. METHODS: Illness details were ascertained from MedWatch reports submitted to the U.S. Food and Drug Administration (FDA) describing consumers who ingested OxyELITE Pro alone or in combination with other dietary supplements...
September 2015: Public Health Reports
https://www.readbyqxmd.com/read/25510478/the-changing-characteristics-of-hepatocellular-cancer-in-hawaii-over-time
#5
Linda L Wong, Makoto Ogihara, Junfang Ji, Naoky Tsai
BACKGROUND: The incidence of hepatocellular cancer (HCC) is increasing, and we sought to characterize the differences and trends in HCC over 2 decades in Hawaii. METHODS: This retrospective study of 821 HCC cases analyzed risk factors, diabetes, alpha-fetoprotein (AFP), tumor characteristics, and treatment, comparing 5-year eras (1993 to 2012). RESULTS: With succeeding eras, there were fewer Asians, immigrants, and hepatitis B-related HCC...
July 2015: American Journal of Surgery
https://www.readbyqxmd.com/read/24022257/litter-quality-versus-soil-microbial-community-controls-over-decomposition-a-quantitative-analysis
#6
Cory C Cleveland, Sasha C Reed, Adrienne B Keller, Diana R Nemergut, Sean P O'Neill, Rebecca Ostertag, Peter M Vitousek
The possible effects of soil microbial community structure on organic matter decomposition rates have been widely acknowledged, but are poorly understood. Understanding these relationships is complicated by the fact that microbial community structure and function are likely to both affect and be affected by organic matter quality and chemistry, thus it is difficult to draw mechanistic conclusions from field studies. We conducted a reciprocal soil inoculum × litter transplant laboratory incubation experiment using samples collected from a set of sites that have similar climate and plant species composition but vary significantly in bacterial community structure and litter quality...
January 2014: Oecologia
https://www.readbyqxmd.com/read/24017353/viral-infections-in-solid-organ-transplants-hitting-a-moving-target
#7
D N Howell, S E Miller
Extended abstract of a paper presented at Microscopy and Microanalysis 2005 in Honolulu, Hawaii, USA, July 31--August 4, 2005.
August 2005: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/24016923/the-identification-and-characterisation-of-transplanted-hematopoietic-stem-cells-in-situ
#8
S Ellis, M Palatsides, S Asquith, B Aisbett, H Johnston, S Nilsson
Extended abstract of a paper presented at Microscopy and Microanalysis 2005 in Honolulu, Hawaii, USA, July 31--August 4, 2005.
August 2005: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/23556532/dermatologist-and-gastroenterologist-awareness-of-the-potential-of-immunosuppressants-used-to-treat-inflammatory-bowel-disease-to-cause-non-melanoma-skin-cancer
#9
Jacqueline F De Luca, Richard Severino, Yun Sun Lee, Douglas Johnson
BACKGROUND:   Immunosuppressants used to treat inflammatory bowel disease (IBD) may contribute towards the development of non-melanoma skin cancer (NMSC). Few studies have documented this increase in risk. METHODS:   A mail-in survey was sent to practicing dermatologists and gastroenterologists in the state of Hawaii, USA. These physicians were asked if they had patients with IBD on immunosuppressants with NMSC and if they were aware of an association between immunosuppressants used in IBD and the occurrence of NMSC...
August 2013: International Journal of Dermatology
https://www.readbyqxmd.com/read/23155491/inflammatory-bowel-disease-treatment-and-non-melanoma-skin-cancer-a-case-report
#10
Jacqueline F De Luca, Yun Sun Lee, Douglas Johnson
Immunosuppressant medications for Inflammatory Bowel Disease can help with both symptoms and disease progression. However, like immunosuppressants used in transplant patients, they are now suspect of contributing to nonmelenoma skin cancer (NMSC). Presented is a case of a 57-year-old Jewish man with Crohn's Disease who was diagnosed with a total of 84 NMSCs. We hope to elucidate the risk of immunosuppressants, particularly the thiopurines, on the development of NMSC.
November 2012: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/22489441/asian-american-adolescents-willingness-to-donate-organs-and-engage-in-family-discussion-about-organ-donation-and-transplantation
#11
Joyce A Trompeta, Bruce A Cooper, Nancy L Ascher, Susan M Kools, Christine M Kennedy, Jyu-Lin Chen
CONTEXT: Despite the growing need for organ donation among Asian Americans, studies suggest that they are reluctant to donate. OBJECTIVE: To examine the association of attitudes and knowledge about organ donation and transplantation with willingness to donate and willingness to engage in family discussion about organ donation among Asian American adolescents. DESIGN: A cross-sectional study. SETTING: The Big Island of Hawaii...
March 2012: Progress in Transplantation
https://www.readbyqxmd.com/read/22227170/healthcare-disparities-in-asians-and-pacific-islanders-with-hepatocellular-cancer
#12
Linda L Wong, Brenda Hernandez, Sandi Kwee, Cheryl L Albright, Gordon Okimoto, Naoky Tsai
BACKGROUND: Hawaii has the highest incidence of hepatocellular cancer (HCC) in the United States and the largest proportion of Asians and Pacific Islanders. HCC studies generally combine these groups into 1 ethnicity, and we sought to examine differences between Asian and Pacific Islander subpopulations. METHODS: Demographic, clinical, and treatment data for 617 patients with HCC (420 Asians, 114 whites, and 83 Pacific Islanders) were reviewed. Main outcome measures included HCC screening and liver transplantation...
June 2012: American Journal of Surgery
https://www.readbyqxmd.com/read/21510206/host-status-of-vaccinium-reticulatum-ericaceae-to-invasive-tephritid-fruit-flies-in-hawaii
#13
Peter A Follett, Francis T Zee
Ohelo (Vaccicinium reticulatum Small) (Ericaceae) is a native Hawaiian plant that has commercial potential in Hawaii as a nursery crop to be transplanted for berry production or for sale as a potted ornamental. No-choice infestation studies were conducted to determine whether ohelo fruit are hosts for four invasive tephritid fruit fly species. Ohelo berries were exposed to gravid female flies ofBactrocera dorsalis Hendel (oriental fruit fly), Ceratitis capitata (Wiedemann) (Mediterranean fruit fly), Bactrocera cucurbitae Coquillet (melon fly),or Bactrocera latifrons (Hendel) in screen cages outdoors for 24 h and then held on sand in the laboratory for 2 wk for pupal development and adult emergence...
April 2011: Journal of Economic Entomology
https://www.readbyqxmd.com/read/20620448/development-of-the-organ-donation-and-transplantation-knowledge-survey-for-use-in-asian-american-adolescents
#14
J A Trompeta, J-L Chen, B A Cooper, N L Ascher, S M Kools
The need for kidney transplantation among Asian Americans is increasing owing to hypertension, diabetes mellitus, and the shortage of available organs. This need is likely to increase as the relatively young Asian population ages. However, knowledge about organ donation and transplantation in this population has been little investigated. The objectives of this study was to develop an Organ Donation and Transplantation Knowledge Survey for use in Asian Americans and to examine its psychometric properties. Internal consistency (Cronbach alpha) and factor analyses were used to determine the reliability and validity of the survey in 121 Asian American adolescents residing on the Big Island of Hawaii...
June 2010: Transplantation Proceedings
https://www.readbyqxmd.com/read/19583104/improving-living-renal-transplant-lessons-from-a-multi-ethnic-transplant-program
#15
Chan W Park, Whitney M Limm, Linda L Wong
Living-renal transplant (LRT) is the most effective treatment for endstage renal disease (ESRD), and innovative strategies to increase donation are needed. We reviewed our ethnically/culturally diverse program to identify factors that contribute to donors' decision to participate. Records of 110 LRT (related:unrelated = 66:44) and respective donors (1999-2005) were reviewed for demographics, outcome, education, employment, language, religion, and motivation. One and 5-year graft survival were 98.2% and 92% respectively...
June 2009: Hawaii Medical Journal
https://www.readbyqxmd.com/read/19385374/racial-disparities-in-pacific-islanders-undergoing-renal-transplant-evaluation
#16
Linda L Wong, Kelly Kindle, Blair Limm
Pacific Islanders currently comprise 35% of all end-stage renal disease patients in Hawai'i but a much smaller proportion of those who undergo renal transplant. The purpose of this study to determine the reasons for such a disparity. In this retrospective review of 207 patients who were referred for renal transplant evaluation, 18.8% were Pacific Islanders. Patients attended a kidney transplant class, were offered evaluation and were placed on the waiting list if deemed appropriate. Of patients that were eventually placed on the list, 18...
March 2009: Hawaii Medical Journal
https://www.readbyqxmd.com/read/19226908/cardiac-transplantation-in-hawai-i-a-summary-of-the-first-21-years
#17
Robert A Hong, Cathy Bailey, Kelly Kindle, Carlos E Moreno-Cabral
Between 1987 and 2008, 45 patients have undergone cardiac transplantation in Hawai'i. This article summarizes the authors' experiences with cardiac transplantation over this 21-year period. The cumulative 1-, 3- and 5-year survival rates after transplantation have been 73.8%, 70.0%, and 63.2%, respectively. The corresponding survival rates have improved over the last eight years and are now 90.0%, 87.5%, and 83.3%, respectively. Despite clinical improvements, low patient volumes make the maintenance of a state-based program in Hawai'i difficult...
November 2008: Hawaii Medical Journal
https://www.readbyqxmd.com/read/18808403/neighborhood-poverty-and-kidney-transplantation-among-us-asians-and-pacific-islanders-with-end-stage-renal-disease
#18
Y N Hall, A M O'Hare, B A Young, E J Boyko, G M Chertow
The degree to which low transplant rates among Asians and Pacific Islanders in the United States are confounded by poverty and reduced access to care is unknown. We examined the relationship between neighborhood poverty and kidney transplant rates among 22 152 patients initiating dialysis during 1995-2003 within 1800 ZIP codes in California, Hawaii and the US-Pacific Islands. Asians and whites on dialysis were distributed across the spectrum of poverty, while Pacific Islanders were clustered in the poorest areas...
November 2008: American Journal of Transplantation
https://www.readbyqxmd.com/read/18210160/adaptive-radiation-of-photosynthetic-physiology-in-the-hawaiian-lobeliads-dynamic-photosynthetic-responses
#19
Rebecca A Montgomery, Thomas J Givnish
Hawaiian lobeliads have radiated into habitats from open alpine bogs to densely shaded rainforest interiors, and show corresponding adaptations in steady-state photosynthetic light responses and associated leaf traits. Shaded environments are not uniformly dark, however, but punctuated by sunflecks that carry most of the photosynthetically active light that strikes plants. We asked whether lobeliads have diversified in their dynamic photosynthetic light responses and how dynamic responses influence daily leaf carbon gain...
March 2008: Oecologia
https://www.readbyqxmd.com/read/16556154/liver-transplant-in-hawaii-the-survival-of-a-small-centre
#20
Linda L Wong, Whitney Limm, Alan Cheung, Hiroji Noguchi
Although many report the importance of case volume in complex cases, liver transplantation (LT) can be carried out successfully in a small centre. During a 11.5-yr period, 88 patients underwent LT in a single transplant centre in Hawaii. Indications for LT were primarily hepatitis C (n = 49) and hepatitis B (n = 13) and 22 patients (25%) had hepatocellular cancer (HCC) on explanted liver. There was no primary graft nonfunction, one retransplant for recurrent hepatitis C and two late hepatic artery thromboses, which did not require a retransplant...
January 2006: Clinical Transplantation
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