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Meta analyse

Torben Glatz, Goran Marjanovic, Jens Hoeppner
BACKGROUND: Chylothorax is a rare complication after thoracic trauma or surgery, especially oesophagectomy, which, if left untreated, can be potentially life-threatening. METHODS: This article provides an overview of the existing literature on the prevention and surgical therapy of chylothorax. RESULTS: The risk of chyle leakage after oesophagectomy increases with the difficulty of mediastinal dissection and is reported to be around 3% for oesophagectomy...
June 2018: Zentralblatt Für Chirurgie
Mojgan Pourhassan, Frank Neumann
The generalized travelling salesperson problem is an important NP-hard combinatorial optimization problem for which meta-heuristics, such as local search and evolutionary algorithms, have been used very successfully. Two hierarchical approaches with different neighbourhood structures, namely a Cluster-Based approach and a Node-Based approach, have been proposed by Hu and Raidl (2008) for solving this problem. In this paper, local search algorithms and simple evolutionary algorithms based on these approaches are investigated from a theoretical perspective...
June 22, 2018: Evolutionary Computation
Yuwei Yang, MengMeng Zhou, Mingjun Hu, Yanjie Cui, Qi Zhong, Ling Liang, Fen Huang
BACKGROUND: Previous articles explored the role of UGT1A1 polymorphism on predicting irinotecan-induced toxicity, but the conclusions were still inconsistent and not comprehensive. We performed this meta-analysis to investigate the association between UGT1A1 polymorphism and irinotecan-induced toxicity. METHODS: PubMed and Web of Science were searched for articles before July 2017. Inclusion and exclusion criteria were set to select eligible articles, and corresponding data were extracted from those articles...
June 22, 2018: Asia-Pacific Journal of Clinical Oncology
Julia Lühnen, Ingrid Mühlhauser, Anke Steckelberg
BACKGROUND: The patient's consent to a medical procedure must be preceded by a pre-procedure discussion with the physician that is documented on a standardized form. Evidence suggests that these forms lack information that would be relevant for an informed decision. METHODS: We carried out a systematic literature search up to February 2017 for evidence on the quality and efficacy of informed consent forms. The definition of criteria for the evaluation of meta-information, content, and presentation were derived from current guidelines for evidence-based health information...
June 1, 2018: Deutsches Ärzteblatt International
Emma A Amissah, Julie Brown, Jane E Harding
BACKGROUND: Preterm infants require high protein intake to achieve adequate growth and development. Although breast milk feeding has many benefits for this population, the protein content is highly variable, and inadequate to support rapid infant growth. This is a 2018 update of a Cochrane Review first published in 1999. OBJECTIVES: To determine whether protein-supplemented human milk compared with unsupplemented human milk, fed to preterm infants, improves growth, body composition, cardio-metabolic, and neurodevelopmental outcomes, without significant adverse effects...
June 22, 2018: Cochrane Database of Systematic Reviews
Chloé Sarnowski, Marie-France Hivert
PURPOSE OF REVIEW: Glycated hemoglobin (A1c) is used to diagnose type 2 diabetes and monitor glycemic control. Specific genetic variants interfere with A1c and effects/frequencies of some variants vary by ancestry. In this review, we summarize findings from large trans-ethnic meta-analyses of genome-wide association studies (GWAS) of A1c and describe some variants influencing erythrocyte biology and interfering with A1c. RECENT FINDINGS: Recent GWAS meta-analyses have revealed 60 loci associated with A1c in multi-ethnic populations...
June 21, 2018: Current Diabetes Reports
S Chiappetta, R Weiner
BACKGROUND: The Mini gastric bypass/One anastomosis gastric bypass (MGB/OAGB) was the third most commonly performed procedure in Germany, with 13.9% of all obesity and metabolic procedures in 2017 (StuDoQ|MBE). OBJECTIVE: This article reviews the currently published evidence for MGB/OAGB and the historical evidence on one anastomosis reconstruction. MATERIAL AND METHODS: A systematic literature search was performed in MEDLINE via PubMed and in Clinicaltrials...
June 21, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
J L Min, G Hemani, G Davey Smith, C Relton, M Suderman
Motivation: DNA methylation datasets are growing ever larger both in sample size and genome coverage. Novel computational solutions are required to efficiently handle these data. Results: We have developed meffil, an R package designed for efficient quality control, normalization and epigenome-wide association studies of large samples of Illumina Methylation BeadChip microarrays. A complete reimplementation of functional normalization minimizes computational memory without increasing running time...
June 21, 2018: Bioinformatics
Huiqian Yu, Huawei Li
Importance: Sudden sensorineural hearing loss (SSHL) accompanied by vertigo may portend a negative prognosis in the hearing outcome. Objective: To investigate the association of vertigo with prognosis of hearing variables in SSHL. Data Sources: A literature search of eligible studies was performed in PubMed, Web of Science, and Embase from September 26, 1973, through September 26, 2017. Studies published in English were retrieved with no restrictions on the date of publication...
June 21, 2018: JAMA Otolaryngology—Head & Neck Surgery
Marta Guasch-Ferré, Jun Li, Frank B Hu, Jordi Salas-Salvadó, Deirdre K Tobias
BACKGROUND: Intervention studies suggest that incorporating walnuts into the diet may improve blood lipids without promoting weight gain. OBJECTIVE: We conducted a systematic review and meta-analysis of controlled trials evaluating the effects of walnut consumption on blood lipids and other cardiovascular risk factors. Design: We conducted a comprehensive search of PubMed and EMBASE databases (from database inception to January 2018) of clinical trials comparing walnut-enriched diets with control diets...
June 21, 2018: American Journal of Clinical Nutrition
James A Greenberg, JoAnn E Manson, Marian L Neuhouser, Lesley Tinker, Charles Eaton, Karen C Johnson, James M Shikany
Background: Three recent meta-analyses found significant prospective inverse associations between chocolate intake and cardiovascular disease risk. Evidence from these meta-analyses suggests that such inverse associations may only apply to elderly individuals or those with pre-existing major chronic disease. Objective: We assessed the association between habitual chocolate intake and subsequent incident coronary heart disease (CHD) and stroke, and the potential effect of modification by age...
June 21, 2018: American Journal of Clinical Nutrition
Johanna Rienks, Janett Barbaresko, Kolade Oluwagbemigun, Matthias Schmid, Ute Nöthlings
Background: Type 2 diabetes is characterized by impaired glucose metabolism. Bioactive compounds in fruits and vegetables such as polyphenols have been suggested to influence glucose metabolism. Objective: The aim of the current study was to systematically review the literature and conduct dose-response meta-analyses to summarize evidence of polyphenol exposure in association with incident type 2 diabetes. Design: Prospective epidemiologic studies published before January 2018 were searched through 2 databases...
June 21, 2018: American Journal of Clinical Nutrition
J Thomas Brenna, Mélanie Plourde, Ken D Stark, Peter J Jones, Yu-Hong Lin
Fatty acids are among the most studied nutrients in human metabolism and health. Endogenous fatty acid status influences health and disease via multiple mechanisms at all stages of the life cycle. Despite widespread interest, attempts to summarize the results of multiple studies addressing similar fatty acid-related outcomes via meta-analyses and systematic reviews have been disappointing, largely because of heterogeneity in study design, sampling, and laboratory and data analyses. Our purpose is to recommend best practices for fatty acid clinical nutrition and medical studies...
June 21, 2018: American Journal of Clinical Nutrition
Ioannis Karavokyros, Adamantios Michalinos
The role of extended lymphadenectomy in the surgical treatment of gastric cancer has been debated for many years. So far six prospective randomized trials and a number of meta-analyses comparing D1 - to D2 -lymphadenectomy in open surgery have been published with contradicting results. The possible oncologic benefit of radical lymphadenectomy has been blurred by a number of reasons. In most of the trials the strategies under comparison were made similar after protocol violations. Imperfect design of the trials could not exclude the influence of cofounding factors...
2018: Frontiers in Surgery
Gholamreza Ghassemi Todeshkchuei, Mitra Molaeinezhad, Sare Ghasemi Todeshkchuei
Suicide is one of the public health problems worldwide, but it lacks regular relevant reporting system. This issue is more important among women who play an influential role in the family and society. Therefore, the assessment of recent relevant studies is important to detect suicide-related factors and to help make the decisions about public health. The aim of the current study was to determine socioeconomic and psychological factors of suicide attempts in Iranian women using a descriptive meta-analysis method...
2018: Advanced Biomedical Research
Hu Wang, Li Wang, Yujia Cheng, Zhiqing Xia, Yifeng Liao, Jiang Cao
In the present meta-analysis, the efficacy and safety of orlistat in the treatment of non-alcoholic fatty liver (NAFLD) and non-alcoholic steatohepatitis (NASH) were evaluated. PubMed, Embase, the Cochrane Library, Web of Science, and Wan Fang data were searched for controlled trials of orlistat in patients with NAFLD or NASH, published before August 2017. Three randomized controlled trials and four single-arm trials were included. The involved participants with NAFLD or NASH (330 patients) were analyzed for clinical outcomes including alteration in hepatic histological variables and biomarkers of liver function...
July 2018: Biomedical Reports
Xue-Feng Li, Ju-Kun Song, Jun-Wei Cai, Yu-Qin Zeng, Min Li, Jie Zhu, Yu-Ming Niu
Previous epidemiologic studies have revealed a possible association between microRNA-608 rs4919510 G>C polymorphism and digestive system cancers (DSCs) risk, but the results were not consistent. We therefore performed an updated meta-analysis to explore the association between microRNA-608 rs4919510 G>C polymorphism and DSCs risk. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the relationship between the microRNA-608 rs4919510 G>C polymorphism and DSCs risk. Heterogeneity, cumulative analyses, sensitivity analyses, and publication bias were also conducted to examine the statistical power...
2018: Frontiers in Physiology
Dane Christina Daoud, Nicolas Suter, Madeleine Durand, Mickael Bouin, Bernard Faulques, Daniel von Renteln
AIM: To compare endoscopic submucosal dissection (ESD) outcomes between Eastern and Western countries. METHODS: A systematic review and meta-analysis was performed using PubMed, MEDLINE, Web of Science, CINAHL and EBM reviews to identify studies published between 1990 and February 2016. The primary outcome was the efficacy of ESD based on information about either curative resection, en bloc or R0 resection rates. Secondary outcomes were complication rates, local recurrence rates and procedure times...
June 21, 2018: World Journal of Gastroenterology: WJG
Y Q Si, X Tang, D D Zhang, L He, Y Cao, J W Wang, N Li, J J Liu, P Gao, Y H Hu
OBJECTIVE: To estimate the potential health benefit of screening strategies for cardiovascular diseases primary prevention in a rural northern Chinese population. METHODS: A total of 6 221 adults aged 40-74 years old, from rural Beijing, China and free from cardiovascular diseases at baseline were included. The following screening strategies were compared: Strategy 1, the strategy based on numbers of risk factors recommended by the Chinese Guideline for Prevention of Cardiovascular Diseases in people aged 40-74; Strategy 2, screening people aged 40-74 based on the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) risk prediction model; Strategy 3, screening people aged 50-74 using the China-PAR risk prediction model...
June 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Nassar Seifo, Waraf Al-Yaseen, Nicola Innes
Data sourcesPubMed, Scopus, Web of Science, the Latin American and Caribbean Health Sciences Literature database (LILACS), the Brazilian Library in Dentistry (BBO), Cochrane Library and grey literature.Study selectionTwo reviewers selected randomised clinical trials (RCTs) that compared the efficacy of SDF application with other active treatments or placebo in arresting carious lesions.Data extraction and synthesisThree authors extracted data using customised extraction forms, and risk of bias was assessed by two independent reviewers...
June 2018: Evidence-based Dentistry
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