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Narges Abdali, Jerry Matthew Parks, Keith Haynes, Julie L Chaney, Adam T Green, David Wolloscheck, John K Walker, Valentin V Rybenkov, Jerome Yves Baudry, Jeremy C Smith, Helen I Zgurskaya
Antibiotic resistance is a major threat to human welfare. Inhibitors of multidrug efflux pumps (EPIs) are promising alternative therapeutics that could revive activities of antibiotics and reduce bacterial virulence. Identification of new druggable sites for inhibition is critical for development of effective EPIs, especially in light of constantly emerging resistance. Here, we describe EPIs that interact with periplasmic membrane fusion proteins, critical components of efflux pumps that are responsible for the activation of the transporter and the recruitment of the outer-membrane channel...
October 21, 2016: ACS Infectious Diseases
Ivan A Zaporozhchenko, Evgeny S Morozkin, Tatyana E Skvortsova, Anastasia A Ponomaryova, Elena Yu Rykova, Nadezhda V Cherdyntseva, Evgeny S Polovnikov, Oksana A Pashkovskaya, Evgeny A Pokushalov, Valentin V Vlassov, Pavel P Laktionov
Lung cancer is a complex disease that often manifests at the point when treatment is not effective. Introduction of blood-based complementary diagnostics using molecular markers may enhance early detection of this disease and help reduce the burden of lung cancer. Here we evaluated the diagnostic potential of seven plasma miRNA biomarkers (miR-21, -19b, -126, -25, -205, -183, -125b) by quantitative reverse transcription PCR. Influence clinical and demographical characteristics, including age, tumor stage and cancer subtype on miRNA levels was investigated...
2016: PloS One
Min Li, Yanan Wang, Yuanjun Zhu, Yingxin Dai, Xufen Hong, Qian Liu, Tianming Li, Juanxiu Qin, Xiaowei Ma, Huiying Lu, Jie Xu, Michael Otto
During 2005-2014, community-associated methicillin-resistant Staphylococcus aureus infections increased in Shanghai, China. Most infections were caused by sequence type 59 S. aureus that lacked Panton-Valentine leukocidin. This finding challenges the notion that Panton-Valentine leukocidin is necessary for epidemiologic success of community-associated methicillin-resistant S. aureus.
November 2016: Emerging Infectious Diseases
Iulia D Ursan, Jerry A Krishnan, A Simon Pickard, Elizabeth Calhoun, Robert DiDomenico, Valentin Prieto-Centurion, Jamie B Sullivan, Lauren Valentino, Mark V Williams, Min Joo
Limited socioeconomic resources contribute to high readmission rates at minority serving institutions (MSIs). A better understanding of patient-level factors and need for patient navigators could inform approaches to enhance care transitions tailored to these vulnerable patient populations. We sought to understand the perspectives of patients and their caregivers about hospital to home transitions from an MSI, as well as their attitudes about patient navigators to facilitate care transitions. We conducted qualitative research using focus groups (FGs)-five disease-specific patient FGs and two caregiver FGs, including 23 patients and 10 caregivers...
2016: Journal of Health Care for the Poor and Underserved
Yicong Wu, Panagiotis Chandris, Peter W Winter, Edward Y Kim, Valentin Jaumouillé, Abhishek Kumar, Min Guo, Jacqueline M Leung, Corey Smith, Ivan Rey-Suarez, Huafeng Liu, Clare M Waterman, Kumaran S Ramamurthi, Patrick J La Riviere, Hari Shroff
Most fluorescence microscopes are inefficient, collecting only a small fraction of the emitted light at any instant. Besides wasting valuable signal, this inefficiency also reduces spatial resolution and causes imaging volumes to exhibit significant resolution anisotropy. We describe microscopic and computational techniques that address these problems by simultaneously capturing and subsequently fusing and deconvolving multiple specimen views. Unlike previous methods that serially capture multiple views, our approach improves spatial resolution without introducing any additional illumination dose or compromising temporal resolution relative to conventional imaging...
August 20, 2016: Optica
Eider M Arenaza-Urquijo, Robin de Flores, Julie Gonneaud, Miranka Wirth, Valentin Ourry, William Callewaert, Brigitte Landeau, Stéphanie Egret, Florence Mézenge, Béatrice Desgranges, Gaël Chételat
Engagement in cognitive activity (CA) and physical activity (PA) during the lifespan may counteract brain atrophy later in life. Here, we investigated engagement in CA and PA during late adulthood in association with gray matter volume (GM) in normal older adults, with special focus on the hippocampus. Forty-five cognitively normal older individuals (mean age: 72) underwent T1-weighted MRI and self-reported CA and PA assessment. Whole brain voxel-wise multiple regression models were carried out to assess the relationships between CA, PA and GM volume adjusted by age and sex...
October 18, 2016: Brain Imaging and Behavior
Mirko Schmidt, Valentin Benzing, Mario Kamer
Classroom-based physical activity breaks are postulated to positively impact children's attention during their school day. However, empirical evidence for this claim is scarce and the role of cognitive engagement in enhancing children's attentional performance is unexplored in studies on physical activity breaks. The aim of the present study was therefore to disentangle the separate and/or combined effects of physical exertion and cognitive engagement induced by physical activity breaks on primary school children's attention...
2016: Frontiers in Psychology
Mar Martin-Pérez, Ana López de Andrés, Valentín Hernández-Barrera, Rodrigo Jiménez-García, Isabel Jiménez-Trujillo, Domingo Palacios-Ceña, Pilar Carrasco-Garrido
INTRODUCTION: Polypharmacy in older people is the result of several inter-connected factors, and is very common despite the associated risks. Not many population-based studies have been conducted in Spain to ascertain the magnitude of polypharmacy in this population. MATERIAL AND METHODS: A descriptive, cross-sectional study was conducted with individualised data for non-institutionalised older people (65 or older) of both sexes from the Spanish National Health Surveys (SNHS) 2006 (N=7,835) and 2011/12 (N=5,896)...
October 15, 2016: Revista Española de Geriatría y Gerontología
Marta Hernández Conde, Elba Llop Herrera, Juan de la Revilla Negro, Fernando Pons Renedo, Natalia Fernández Puga, José Luis Martínez Porras, María Trapero Marugan, Valentín Cuervas-Mons, Víctor Sánchez Turrión, José Luis Calleja Panero
INTRODUCTION: The prevalence of portal vein thrombosis (PVT) in patients that have undergone liver transplantation (LT) is 9.7% (SD 4.5). The aim of our study was to determine the prevalence, assess the factors that are associated with PVT and clarify their association with prognosis in patients with liver cirrhosis (LC) and LT. AIMS AND METHODS: From 2005 to 2014, laboratory, radiological and surgical data were collected from patients with LC in our center who had undergone LT for the first time...
October 19, 2016: Revista Española de Enfermedades Digestivas
Yancheng Yang, Zhen Hu, Weilong Shang, Qiwen Hu, Junmin Zhu, Jie Yang, Huagang Peng, Xiaopeng Zhang, Hui Liu, Yanguang Cong, Shu Li, Xiaomei Hu, Renjie Zhou, Xiancai Rao
Methicillin-susceptible Staphylococcus aureus (MSSA) accounts for ∼40% of staphylococcal infections in China. However, the molecular characterization of MSSA is not well described. In this study, 124 MSSA strains collected in 2013 from a comprehensive teaching hospital in Chongqing, Southwestern China, were subjected to antibiotics susceptibility testing and molecular typing, including multilocus sequence typing, staphylococcal protein A (spa) gene typing, accessory gene regulator (agr) typing, pulsed-field gel electrophoresis (PFGE) typing, Panton-Valentine leukocidin (pvl) gene detection, and antibiotic-resistant gene detection...
October 18, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Hui Li, Qinying Pan, Yunchao Ma, Xinyu Guan, Ming Xue, Qianrong Fang, Yushan Yan, Valentin Valtchev, Shilun Qiu
Covalent organic frameworks (COFs) are an emerging class of porous crystalline polymers with broad potential applications. So far, the availability of 3D COFs is limited and more importantly only one type of covalent bond has been successful used for 3D COF materials. Here, we report a new synthetic strategy based on dual linkages that leads to 3D COFs. The obtained 3D COFs show high specific surface areas and large gas uptake capacities, which makes them the top COF material for gas uptake. Furthermore, we demonstrate that the new 3D COFs comprise both acidic and basic sites, and act as excellent bifunctional catalysts for one-pot cascade reactions...
October 18, 2016: Journal of the American Chemical Society
Thomas P J Blaikie, John Howard Couper, Gus Hancock, Philip L Hurst, Robert Peverall, Graham Richmond, Grant A D Ritchie, David Taylor, Kevin Valentine
A portable and compact device is demonstrated for measuring acetone in breath samples. The device features a 7 cm long high finesse optical cavity as an optical sensor that is coupled to a miniature adsorption preconcentrator containing 0.5 g of polymer material. Acetone is trapped out of breath and released into the optical cavity where it is probed by a near-infrared diode laser operating at ~1670 nm. With an optical cavity mirror reflectivity of 99.994 % a limit of detection of 159 ppbv (1σ) is demonstrated on samples from breath bags...
October 18, 2016: Analytical Chemistry
Ivan D Osipov, Ivan A Zaporozhchenko, Anna A Bondar, Marat M Zaripov, Vladimir E Voytsitskiy, Valentin V Vlassov, Pavel P Laktionov, Evgeny S Morozkin
Expression levels of five miRNAs (miR-19b, miR-21, miR-126, miR-141, miR-205) were measured in the plasma of healthy donors and prostate cancer patients. It was shown that miR-141 expression level efficiently discriminates early stage prostate cancer patients and correlates with the Gleason score.
2016: Advances in Experimental Medicine and Biology
Philippine Fassier, Laurent Zelek, Valentin Partula, Bernard Srour, Patrick Bachmann, Marina Touillaud, Nathalie Druesne-Pecollo, Pilar Galan, Patrice Cohen, Hélène Hoarau, Paule Latino-Martel, Mehdi Menai, Jean-Michel Oppert, Serge Hercberg, Mélanie Deschasaux, Mathilde Touvier
Physical activity (PA) but also reduced sedentary behavior may be associated with better prognosis and lower risk of recurrence in cancer patients. Our aim was to quantify the variations in PA and time spent sedentary between before and after diagnosis, relying on prospective data in French adults. We also investigated sociodemographic and lifestyle factors associated with these variations.Subjects (n = 942) were incident cancer cases diagnosed in the NutriNet-Santé cohort between 2009 and 2015. PA and sedentary behavior were prospectively collected with the 7-day short version of the IPAQ questionnaire every year since subjects' inclusion (i...
October 2016: Medicine (Baltimore)
David C Rees, Valentine A M Brousse
No abstract text is available yet for this article.
June 2016: Indian Journal of Medical Research
Natália Martinez Fernandes, Isadora Gonçalves Pelissari, Licia Assunção Cogo, Valdete Alves Valentins Dos Santos Filha
Introduction The manipulation of antineoplastic drugs presents high risk for accidents and occupational diseases. Objective To evaluate the auditory and vestibular systems of workers who are exposed to chemotherapeutic treatment in the University Hospital of Universidade Federal de Santa Maria, Brazil, and to identify the use of individual protection equipment, related to the obtained results. Methods This study is a cross-sectional study using a quantitative method. We evaluate 33 male and female workers, ranging from 21-60 years old, of the nursing and pharmacy sectors...
October 2016: International Archives of Otorhinolaryngology
Yaroslav Staroseletz, Aled Williams, Kepa K Burusco, Irfan Alibay, Valentin V Vlassov, Marina A Zenkova, Elena V Bichenkova
Traditional therapeutic interventions against abnormal gene expression in disease states at the level of expressed proteins are becoming increasingly difficult due to poor selectivity, off-target effects and associated toxicity. Upstream catalytic targeting of specific RNA sequences offers an alternative platform for drug discovery to achieve more potent and selective treatment through antisense interference with disease-relevant RNAs. We report a novel class of catalytic biomaterials, comprising amphipathic RNA-cleaving peptides placed between two RNA recognition motifs, here demonstrated to target the TΨC loop and 3'- acceptor stem of tRNA(Phe)...
October 3, 2016: Biomaterials
V Valentin, J Chabrol, G Lefevre, F Bart, J-B Faivre, B Wallaert
No abstract text is available yet for this article.
October 12, 2016: Revue des Maladies Respiratoires
Patricia L Tavormina, Matthias Y Kellermann, Chakkiath Paul Antony, Elitza Tocheva, Nathan Dalleska, Ashley J Jensen, David L Valentine, Kai-Uwe Hinrichs, Grant Jensen, Nicole Dubilier, Victoria J Orphan
In the deep ocean, the conversion of methane into derived carbon and energy drives the establishment of diverse faunal communities. Yet specific biological mechanisms underlying the introduction of methane-derived carbon into the food web remain poorly described, due to a lack of cultured representative deep-sea methanotrophic prokaryotes. Here, we characterize the response of the deep-sea aerobic methanotroph Methyloprofundus sedimenti to methane starvation and recovery. By combining lipid analysis, RNA analysis, and electron cryotomography, we show that M...
October 14, 2016: Molecular Microbiology
Anca Meda Georgescu, Leonard Azamfirei, Krisztina Szalman, Edit Szekely
BACKGROUND: Over the last decades Staphylococcus aureus (SA) has become the dominant etiology of native valve infective endocarditis, with the community-acquired methicillin-sensible Staphylococcus aureus (CA-MSSA) strains being the prevailing type. CASE: We report here a case of extremely severe CA-MSSA aortic valve acute endocarditis associated with persistent Staphylococcus aureus bacteremia (SAB) in a previously healthy man and include a literature review.The patient developed severe and rare complications (purpura, purulent pericarditis, intracerebral hematoma, and rhabdomyolysis) through systemic embolism; they required drainage of pericardial empyema and cerebral hematoma, the latter eventually caused a fatal outcome...
October 2016: Medicine (Baltimore)
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