keyword
https://read.qxmd.com/read/38537198/biokc-a-collaborative-platform-for-curation-and-annotation-of-molecular-interactions
#1
JOURNAL ARTICLE
Carlos Vega, Marek Ostaszewski, Valentin Grouès, Reinhard Schneider, Venkata Satagopam
Curation of biomedical knowledge into systems biology diagrammatic or computational models is essential for studying complex biological processes. However, systems-level curation is a laborious manual process, especially when facing ever-increasing growth of domain literature. New findings demonstrating elaborate relationships between multiple molecules, pathways and cells have to be represented in a format suitable for systems biology applications. Importantly, curation should capture the complexity of molecular interactions in such a format together with annotations of the involved elements and support stable identifiers and versioning...
March 27, 2024: Database: the Journal of Biological Databases and Curation
https://read.qxmd.com/read/38537146/first-report-of-neofabraea-actinidiae-causing-a-cranberry-fruit-rot-in-oregon
#2
JOURNAL ARTICLE
Don C Valentine, Brenda T Shaffer, Gayle C McGhee, Cassie Bouska, Virginia Stockwell
Cranberry ( Vaccinium macrocarpon , L.) is a commercial small fruit that is native to North America. Oregon ranks fourth in cranberry production in the U.S.A. with 1052 Ha of cranberry beds and annual production of 23,590 metric tonnes (USDA NASS 2021). Cranberry fruit rot diseases are caused by a complex of 15 fungal pathogens belonging to 10 genera (Polashock et al. 2017). In fruit rot surveys of 'Stevens' cranberry beds in Coos and Curry Counties, Oregon, berries were collected before harvest and sorted by symptoms (e...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537067/conventional-epithelial-off-corneal-crosslinking-in-patients-with-progressive-keratoconus-10-year-outcomes
#3
JOURNAL ARTICLE
Jérémy Bordais, Myriam Cassagne, David Touboul, Valentine Saunier, Jacqueline Butterworth, François Malecaze, Vincent Soler, Pierre Fournié
PURPOSE: Corneal crosslinking (CXL) is the standard treatment of progressive keratoconus (KC). We evaluated the safety and 10-year outcomes of conventional "epithelial-off" CXL for progressive KC for the first time in a cohort in France. METHODS: We conducted a retrospective review of patients undergoing conventional CXL (Dresden protocol) in our tertiary ophthalmology department from 2006 to 2011 with 10-year follow-up. The primary outcome was change in preoperative versus postoperative keratometry measured by maximum keratometry (Kmax), steep keratometry (K2), flat keratometry (K1), mean keratometry (Km), and topographic cylinder...
March 27, 2024: Cornea
https://read.qxmd.com/read/38536505/metabolic-changes-contribute-to-maladaptive-right-ventricular-hypertrophy-in-pulmonary-hypertension-beyond-pressure-overload-an-integrative-imaging-and-omics-investigation
#4
JOURNAL ARTICLE
Inés García-Lunar, Inmaculada Jorge, Jorge Sáiz, Núria Solanes, Ana Paula Dantas, Juan José Rodríguez-Arias, María Ascaso, Carlos Galán-Arriola, Francisco Rafael Jiménez, Elena Sandoval, Jorge Nuche, Maria Moran-Garrido, Emilio Camafeita, Montserrat Rigol, Javier Sánchez-Gonzalez, Valentín Fuster, Jesús Vázquez, Coral Barbas, Borja Ibáñez, Daniel Pereda, Ana García-Álvarez
Right ventricular (RV) failure remains the strongest determinant of survival in pulmonary hypertension (PH). We aimed to identify relevant mechanisms, beyond pressure overload, associated with maladaptive RV hypertrophy in PH. To separate the effect of pressure overload from other potential mechanisms, we developed in pigs two experimental models of PH (M1, by pulmonary vein banding and M2, by aorto-pulmonary shunting) and compared them with a model of pure pressure overload (M3, pulmonary artery banding) and a sham-operated group...
March 27, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38535177/chromoblastomycosis-in-french-guiana-epidemiology-and-practices-1955-2023
#5
JOURNAL ARTICLE
Julie Valentin, Geoffrey Grotta, Thibaut Muller, Pieter Bourgeois, Kinan Drak Alsibai, Magalie Demar, Pierre Couppie, Romain Blaizot
Chromoblastomycosis (CBM) is a chronic neglected fungal disease, usually met in tropical areas. French Guiana is a South American territory with limited epidemiological data. This retrospective study concerned all patients with CBM proven by at least one paraclinical examination and diagnosed in French Guiana between 1950 and 2023. In total, 23 patients were included, mostly males (87%) of Creole origin, living in the coastal region (87%) and involved in outdoor occupations (74%). Lesions were mostly observed on the lower limbs (78...
February 22, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535009/cardiac-magnetic-resonance-imaging-based-ischemic-injury-pattern-in-patients-with-acute-myocardial-infarction-sensu-left-ventricular-global-systolic-function
#6
JOURNAL ARTICLE
Lyudmila Salyamova, Valentin Oleynikov, Natalia Donetskaya, Alexander Vdovkin, Angelina Chernova, Irina Avdeeva
The purpose of the study was to identify factors characterizing a decrease in LV global systolic function in patients with ST-segment elevation myocardial infarction (STEMI) after revascularization using cardiac magnetic resonance imaging (MRI)-based ischemic injury pattern and laboratory parameters sensu left ventricular global systolic function. A total of 109 STEMI patients were examined. The patients underwent contrast-enhanced cardiac MRI with a 1.5 Tesla GE SIGNA Voyager (GE HealthCare, Chicago, IL, USA) on the 7th-10th days from the onset of the disease...
March 11, 2024: Diagnostics
https://read.qxmd.com/read/38534593/recent-advances-of-chitosan-based-hydrogels-for-skin-wound-dressings
#7
REVIEW
Wei Guo, Xiaoyue Ding, Han Zhang, Zhenzhong Liu, Yanting Han, Qianqian Wei, Oseweuba Valentine Okoro, Amin Shavandi, Lei Nie
The management of wound healing represents a significant clinical challenge due to the complicated processes involved. Chitosan has remarkable properties that effectively prevent certain microorganisms from entering the body and positively influence both red blood cell aggregation and platelet adhesion and aggregation in the bloodstream, resulting in a favorable hemostatic outcome. In recent years, chitosan-based hydrogels have been widely used as wound dressings due to their biodegradability, biocompatibility, safety, non-toxicity, bioadhesiveness, and soft texture resembling the extracellular matrix...
February 29, 2024: Gels
https://read.qxmd.com/read/38534481/standardization-of-a-ct-protocol-for-imaging-patients-with-suspected-covid-19-a-racoon-project
#8
JOURNAL ARTICLE
Andrea Steuwe, Benedikt Kamp, Saif Afat, Alena Akinina, Schekeb Aludin, Elif Gülsah Bas, Josephine Berger, Evelyn Bohrer, Alexander Brose, Susanne Martina Büttner, Constantin Ehrengut, Mirjam Gerwing, Sergio Grosu, Alexander Gussew, Felix Güttler, Andreas Heinrich, Petra Jiraskova, Christopher Kloth, Jonathan Kottlors, Marc-David Kuennemann, Christian Liska, Nora Lubina, Mathias Manzke, Felix G Meinel, Hans-Jonas Meyer, Andreas Mittermeier, Thorsten Persigehl, Lars-Patrick Schmill, Manuel Steinhardt, The Racoon Study Group, Gerald Antoch, Birte Valentin
CT protocols that diagnose COVID-19 vary in regard to the associated radiation exposure and the desired image quality (IQ). This study aims to evaluate CT protocols of hospitals participating in the RACOON (Radiological Cooperative Network) project, consolidating CT protocols to provide recommendations and strategies for future pandemics. In this retrospective study, CT acquisitions of COVID-19 patients scanned between March 2020 and October 2020 (RACOON phase 1) were included, and all non-contrast protocols were evaluated...
February 22, 2024: Bioengineering
https://read.qxmd.com/read/38533868/case-study-of-invalid-to-valid-shift-in-cognitive-performance-following-successful-treatment-of-psychogenic-nonepileptic-seizure-events
#9
JOURNAL ARTICLE
Daniel L Drane, Kelsey C Hewitt, Michele E Price, Beth K Rush, Karen Blackmon, Noah Okada, Taylor Shade, Edward Valentin, Joseph Vinson, Phyllis Rosen, David W Loring
Patients with psychogenic nonepileptic seizure (PNES) who fail performance validity testing (PVT) may appear to produce non-valid cognitive profiles. Consequently, they may not get referred to treatment and events persist, with worsening disability and high resource utilization. As a result, we report pre- and post-treatment neuropsychological evaluation findings in a 59-year-old woman with a confirmed diagnosis of PNES established using video-EEG monitoring. At pre-treatment baseline neuropsychological evaluation, PNES events occurred weekly to daily...
March 27, 2024: Journal of Clinical and Experimental Neuropsychology
https://read.qxmd.com/read/38533466/tachaid-an-interactive-tool-supporting-the-design-of-human-centered-ai-solutions
#10
JOURNAL ARTICLE
Max Bauroth, Pavlos Rath-Manakidis, Valentin Langholf, Laurenz Wiskott, Tobias Glasmachers
In an era where Artificial Intelligence (AI) integration into business processes is crucial for maintaining competitiveness, there is a growing need for structured guidance on designing AI solutions that align with human needs. To this end, we present "technical assistance concerning human-centered AI development" (tachAId), an interactive advisory tool which comprehensively guides AI developers and decision makers in navigating the machine learning lifecycle with a focus on human-centered design. tachAId motivates and presents concrete technical advice to ensure human-centeredness across the phases of AI development...
2024: Frontiers in artificial intelligence
https://read.qxmd.com/read/38532802/patisiran-exposure-in-early-pregnancy-a-case-report
#11
Valentin Loser, Thomas Baumgartner, Hélène Legardeur, Alice Panchaud, Marie Théaudin
We describe here the first case of exposure to patisiran treatment, a small interfering RNA molecule, during early pregnancy of a 36-year-old woman with symptomatic hereditary transthyretin-related amyloidosis. There were no major complications during pregnancy and delivery, except for a postpartum hemorrhage due to uterine atony. Vitamin A levels had to be closely monitored during pregnancy, and vitamin A substitution adapted accordingly. There was no sign of minor or major congenital abnormalities of the baby...
2024: Therapeutic Advances in Neurological Disorders
https://read.qxmd.com/read/38532479/improving-crispr-cas9-directed-faithful-transgene-integration-outcomes-by-reducing-unwanted-random-dna-integration
#12
JOURNAL ARTICLE
Rio Hermantara, Laura Richmond, Aqeel Faisal Taqi, Sabari Chilaka, Valentine Jeantet, Ileana Guerrini, Katherine West, Adam West
BACKGROUND: The field of genome editing has been revolutionized by the development of an easily programmable editing tool, the CRISPR-Cas9. Despite its promise, off-target activity of Cas9 posed a great disadvantage for genome editing purposes by causing DNA double strand breaks at off-target locations and causing unwanted editing outcomes. Furthermore, for gene integration applications, which introduce transgene sequences, integration of transgenes to off-target sites could be harmful, hard to detect, and reduce faithful genome editing efficiency...
March 26, 2024: Journal of Biomedical Science
https://read.qxmd.com/read/38531539/patient-satisfaction-with-ultrasound-whole-body-ct-and-whole-body-diffusion-weighted-mri-for-pre-operative-ovarian-cancer-staging-a-multicenter-prospective-cross-sectional-survey
#13
JOURNAL ARTICLE
Patrícia Pinto, Lil Valentin, Martina Borčinová, Markéta Wiesnerová, Fruhauf Filip, Andrea Burgetova, Martin Masek, Lukas Lambert, Valentina Chiappa, Dorella Franchi, Antonia Carla Testa, Francesca Moro, Giacomo Avesani, Camilla Panico, Sarah Alessi, Paola Pricolo, Raffaella Vigorito, Giuseppina Calareso, Roman Kocian, Jiri Slama, Anna Fagotti, Ailyn Mariela Vidal Urbinati, Mauro Signorelli, Francesca Bertolina, David Cibula, Daniela Fischerova
BACKGROUND: In addition to the diagnostic accuracy of imaging methods, patient-reported satisfaction with imaging methods is important. OBJECTIVE: To report a secondary outcome of the prospective international multicenter Imaging Study in Advanced ovArian Cancer (ISAAC Study), detailing patients' experience with abdomino-pelvic ultrasound, whole-body contrast-enhanced computed tomography (CT), and whole-body diffusion-weighted magnetic resonance imaging (WB-DWI/MRI) for pre-operative ovarian cancer work-up...
March 26, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38530751/radiolabeled-multi-layered-coated-gold-nanoparticles-as-potential-biocompatible-pet-spect-tracers
#14
JOURNAL ARTICLE
Cristina M Uritu, Cristina M Al-Matarneh, Denisse I Bostiog, Adina Coroaba, Vlad Ghizdovat, Silviu I Filipiuc, Natalia Simionescu, Cipriana Stefanescu, Wael Jalloul, Valentin Nastasa, Bogdan I Tamba, Stelian S Maier, Mariana Pinteala
The demand for tailored, disease-adapted, and easily accessible radiopharmaceuticals is one of the most persistent challenges in nuclear imaging precision medicine. The aim of this work was to develop two multimodal radiotracers applicable for both SPECT and PET techniques, which consist of a gold nanoparticle core, a shell involved in radioisotope entrapment, peripherally placed targeting molecules, and biocompatibilizing polymeric sequences. Shell decoration with glucosamine units located in sterically hindered molecular environments is expected to result in nanoparticle accumulation in high-glucose-consuming areas...
March 26, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38528030/single-drop-cytometry-onboard-the-international-space-station
#15
JOURNAL ARTICLE
Daniel J Rea, Rachael S Miller, Brian E Crucian, Russell W Valentine, Samantha Cristoforetti, Samuel B Bearg, Zlatko Sipic, Jamie Cheng, Rebecca Yu, Kimesha M Calaway, Dexter Eames, Emily S Nelson, Beth E Lewandowski, Gail P Perusek, Eugene Y Chan
Real-time lab analysis is needed to support clinical decision making and research on human missions to the Moon and Mars. Powerful laboratory instruments, such as flow cytometers, are generally too cumbersome for spaceflight. Here, we show that scant test samples can be measured in microgravity, by a trained astronaut, using a miniature cytometry-based analyzer, the rHEALTH ONE, modified specifically for spaceflight. The base device addresses critical spaceflight requirements including minimal resource utilization and alignment-free optics for surviving rocket launch...
March 25, 2024: Nature Communications
https://read.qxmd.com/read/38528004/ska2-regulated-hyperactive-secretory-autophagy-drives-neuroinflammation-induced-neurodegeneration
#16
JOURNAL ARTICLE
Jakob Hartmann, Thomas Bajaj, Joy Otten, Claudia Klengel, Tim Ebert, Anne-Kathrin Gellner, Ellen Junglas, Kathrin Hafner, Elmira A Anderzhanova, Fiona Tang, Galen Missig, Lindsay Rexrode, Daniel T Trussell, Katelyn X Li, Max L Pöhlmann, Sarah Mackert, Thomas M Geiger, Daniel E Heinz, Roy Lardenoije, Nina Dedic, Kenneth M McCullough, Tomasz Próchnicki, Thomas Rhomberg, Silvia Martinelli, Antony Payton, Andrew C Robinson, Valentin Stein, Eicke Latz, William A Carlezon, Felix Hausch, Mathias V Schmidt, Chris Murgatroyd, Sabina Berretta, Torsten Klengel, Harry Pantazopoulos, Kerry J Ressler, Nils C Gassen
High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. Here we show that secretory autophagy (SA), a non-lytic modality of autophagy for secretion of vesicular cargo, regulates neuroinflammation-mediated neurodegeneration via SKA2 and FKBP5 signaling. SKA2 inhibits SA-dependent IL-1β release by counteracting FKBP5 function. Hippocampal Ska2 knockdown in male mice hyperactivates SA resulting in neuroinflammation, subsequent neurodegeneration and complete hippocampal atrophy within six weeks...
March 25, 2024: Nature Communications
https://read.qxmd.com/read/38527394/iron-deficiency-in-pernicious-anemia-specific-features-of-iron-deficient-patients-and-preliminary-data-on-response-to-iron-supplementation
#17
JOURNAL ARTICLE
Juliette Rogez, Geoffrey Urbanski, Emeline Vinatier, Christian Lavigne, Léa Emmanuel, Iris Dupin, Camille Ravaiau, Valentin Lacombe
BACKGROUND & AIMS: While vitamin B12 (B12) deficiency is considered as the hallmark of pernicious anemia (PA), iron deficiency (ID) is also prevalent. Indeed, this auto immune gastritis is responsible for parietal cell atrophy and increase in gastric pH, leading to impaired iron absorption. We compared PA patients' features according to their iron status at PA diagnosis, and we assessed the iron status recovery after oral or intravenous iron supplementation. METHODS: We prospectively included patients presenting with a newly diagnosed PA in a tertiary referral hospital between November 2018 and October 2020...
March 20, 2024: Clinical Nutrition
https://read.qxmd.com/read/38527183/topical-insulin-for-ocular-surface-disease
#18
JOURNAL ARTICLE
Pau Cid-Bertomeu, Magí Vilaltella, Mireia Martínez, Marta Mir, Valentín Huerva
Background: Insulin and insulin-like growth factor (IGF)-1 receptors are present in ocular tissues such as corneal epithelium, keratocytes, and conjunctival cells. Insulin plays a crucial role in the growth, differentiation, and proliferation of corneal epithelial cells, as well as in wound healing processes in various tissues. Purpose: This review explores the potential role of topical insulin in the treatment of ocular surface diseases. Specifically, it examines its impact on corneal nerve regeneration, sub-basal plexus corneal nerves, and its application in conditions like corneal epithelial defects, dry eye disease, and diabetic keratopathy...
March 22, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38524851/corrigendum-revisiting-multi-omics-based-predictors-of-the-plasma-triglyceride-response-to-an-omega-3-fatty-acid-supplementation
#19
Josiane Morin-Bernier, Juan de Toro-Martín, Valentin Barbe, Rodrigo San-Cristobal, Simone Lemieux, Iwona Rudkowska, Patrick Couture, Olivier Barbier, Marie-Claude Vohl
[This corrects the article DOI: 10.3389/fnut.2024.1327863.].
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38524136/detection-of-staphylococcus-aureus-virulence-gene-pvl-based-on-crispr-strip
#20
JOURNAL ARTICLE
Li Jin, XiaoFeng Hu, Yuan Tian, MengYa Fang, Xue Dong, YaXuan Jiang, Yao Han, Hao Li, Yansong Sun
INTRODUCTION: Staphylococcus aureus ( S. aureus ) is a prominent pathogen responsible for both hospital-acquired and community-acquired infections. Among its arsenal of virulence factors, Panton-Valentine Leucocidin (PVL) is closely associated with severe diseases such as profound skin infections and necrotizing pneumonia. Patients infected with pvl -positive S. aureus often exhibit more severe symptoms and carry a substantially higher mortality risk. Therefore, it is crucial to promptly and accurately detect pvl -positive S...
2024: Frontiers in Immunology
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