Mariana Reis Guedes, Sylvana Izaura Salyba Rendeiro de Noronha, Máira Tereza Talma Chírico, Gabriela Dias Carvalho da Costa, Thalles de Freitas Castro, Rory Cristiane Fortes de Brito, Lucas Gabriel Vieira, Thayane Oliveira Reis, Marcelo Carlos Ribeiro, Alexandre Barbosa Reis, Cláudia Martins Carneiro, Frank Silva Bezerra, Nicola Montano, Valdo José Dias da Silva, Rodrigo Cunha de Menezes, Deoclécio Alves Chianca-Jr, Fernanda Cacilda Silva
UNLABELLED: Malnutrition results in autonomic imbalance and heart hypertrophy. Overexpression of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the left ventricles (LV) is linked to hypertrophied hearts and abnormal myocardium automaticity. Given that ivabradine (IVA) has emerging pleiotropic effects, in addition to the widely known bradycardic response, this study evaluated if IVA treatment could repair the autonomic control and cardiac damages in malnourished rats...
April 11, 2024: Life Sciences