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https://www.readbyqxmd.com/read/29754945/decision-analysis-defining-optimal-management-of-clinical-stage-1-high-risk-nonseminomatous-germ-cell-testicular-cancer-with-lymphovascular-invasion
#1
Svetlana Avulova, Clayton Allen, Alicia Morgans, Kelvin A Moses
BACKGROUND: Risk of recurrent disease for men with clinical stage 1 high-risk nonseminomatous germ cell testicular cancer (CS1 NSGCT) with lymphovascular invasion (LVI) after orchiectomy is 50% and current treatment options (surveillance [S], retroperitoneal lymph node dissection [RPLND], or 1 cycle of BEP [BEP ×1]) are associated with a 99% disease specific survival, therefore practice patterns vary. We performed a decision analysis using updated data of long-term complications for men with CS1 NSGCT with LVI to quantify and assess relative treatment values...
May 10, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29728822/robot-assisted-supine-extraperitoneal-retroperitoneal-lymph-node-dissection-a-novel-approach-for-template-dissection-in-post-chemotherapy-residual-mass-in-non-seminomatous-germ-cell-tumours
#2
Ginil Kumar Pooleri, Priyank Bijalwan, Rajesh Kesavan, Arun Philip, Pavithran Keechilat
Robot-assisted retroperitoneal lymph node dissection (RA-RPLND) in testicular cancer is conventionally performed through transperitoneal route. We report a case of robot-assisted supine extraperitoneal RPLND (RASE-RPLND), not previously described in the literature, which was performed for post-chemotherapy residual mass in a case of non-seminomatous germ cell tumour (NSGCT). RASE-RPLND apart from providing the benefits of robotic assistance has a significant advantage over transperitoneal approach, as the procedure can be performed in supine position without any bowel handling...
May 4, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29704586/histologic-and-oncologic-outcomes-following-liver-mass-resection-with-retroperitoneal-lymph-node-dissection-in-patients-with-non-seminomatous-germ-cell-tumor
#3
Eugene J Pietzak, Melissa Assel, Maria F Becerra, Daniel Tennenbaum, Darren R Feldman, Dean F Bajorin, Robert J Motzer, George J Bosl, Brett S Carver, Daniel D Sjoberg, Joel Sheinfeld
OBJECTIVE: To evaluate the oncologic outcomes and histologic concordance of post-chemotherapy residual liver mass resection with post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND). METHODS: Retrospective review of our prospectively maintained germ cell tumor (GCT) surgical database identified patients with non-seminomatous GCT (NSGCT) who underwent both post-chemotherapy residual liver mass resection and PC-RPLND between 1990 and 2015. RESULTS: A total of 36 patients were identified, of whom 29 (81%) presented with a liver mass at initial diagnosis and 17 (47%) received second-line chemotherapy prior to liver resection...
April 25, 2018: Urology
https://www.readbyqxmd.com/read/29660851/temporal-trends-in-management-and-outcomes-of-testicular-cancer-a-population-based-study
#4
Michael J Leveridge, D Robert Siemens, Kelly Brennan, Jason P Izard, Safiya Karim, Howard An, William J Mackillop, Christopher M Booth
BACKGROUND: Treatment guidelines for early-stage testicular cancer have increasingly recommended de-escalation of therapy with surveillance strategies. This study was designed to describe temporal trends in routine clinical practice and to determine whether de-escalation of therapy is associated with inferior survival in the general population. METHODS: The Ontario Cancer Registry was linked to electronic records of treatment to identify all patients diagnosed with testicular cancer treated with orchiectomy in Ontario during 2000-2010...
April 16, 2018: Cancer
https://www.readbyqxmd.com/read/29563747/role-of-rplnd-and-metastasectomy-in-the-management-of-oligometastatic-renal-cell-carcinoma
#5
H Nagaraja, N Srivatsa, S Hemalatha, S Shweta, S K Raghunath
Although lymphadenectomy is currently accepted as most accurate and reliable staging procedure for lymph node metastases, its therapeutic benefit in renal cell carcinoma (RCC) still remains controversial. Although the new, targeted therapy paradigms have changed the treatment of patients with advanced RCC and offer prolonged survival, cure is extremely uncommon in the absence of surgical resections. In this paper, the current role of metastasectomy is reviewed. Review the available literature concerning the role of retroperitoneal lymph node dissection and metastasectomy in outcome of oligometastatic RCC...
March 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29506850/retroperitoneal-lymph-node-staging-in-paratesticular-rhabdomyosarcoma-are-we-meeting-expectations
#6
Emma C Hamilton, Charles C Miller, Michael Joseph, Winston W Huh, Andrea A Hayes-Jordan, Mary T Austin
BACKGROUND: Staging retroperitoneal lymph node dissection (RPLND) for paratesticular rhabdomyosarcoma (RMS) is recommended for all patients aged ≥10 y. The purpose of this study was to evaluate adherence with surgical resection guidelines for RPLND in patients with paratesticular RMS as a measure for surgical quality. MATERIALS AND METHODS: All patients with paratesticular RMS were identified in the Surveillance, Epidemiology, and End Results database from 1973 to 2012...
April 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29487620/retroperitoneal-lymph-node-dissection-as-primary-treatment-for-metastatic-seminoma
#7
REVIEW
Brian Hu, Siamak Daneshmand
Reducing the long-term morbidity in testicular cancer survivors represents a major area of interest. External beam radiation therapy and systemic chemotherapy are established treatments for seminoma; however, they are associated with late toxicities such as cardiovascular disease, insulin resistance, and secondary malignancy. Retroperitoneal lymph node dissection (RPLND) is a standard treatment for nonseminomatous germ cell tumors (NSGCT) that has minimal long-term morbidity. Given the efficacy of RPLND in management of NSGCT, interest has developed in this surgery as a front-line treatment for seminoma with isolated lymph node metastasis to the retroperitoneum...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29474847/serum-mirna-predicts-viable-disease-after-chemotherapy-in-patients-with-testicular-nonseminoma-germ-cell-tumor
#8
Ricardo Leão, Ton van Agthoven, Arnaldo Figueiredo, Michael A S Jewett, Kamel Fadaak, Joan Sweet, Ardalan E Ahmad, Lynn Anson-Cartwright, Peter Chung, Aaron Hansen, Padraig Warde, Pedro Castelo-Branco, Martin O'Malley, Philippe L Bedard, Leendert H J Looijenga, Robert J Hamilton
PURPOSE: Retroperitoneal lymph node dissection is recommended for residual masses greater than 1 cm after chemotherapy of nonseminomatous germ cell tumors. Currently to our knowledge there is no reliable predictor of post-chemotherapy retroperitoneal lymph node dissection histology. Up to 50% of patients harbor necrosis/fibrosis only so that a potentially morbid surgery has limited therapeutic value. In this study we evaluated the ability of defined serum miRNAs to predict residual viable nonseminomatous germ cell tumors after chemotherapy...
February 21, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29474141/robot-assisted-retroperitoneal-lymphadenectomy-in-testicular-cancer-treatment-a-systematic-review
#9
Aggelos Tselos, Demetrios Moris, Diamantis I Tsilimigras, Evangelos Fragkiadis, Eustratia Mpaili, Panagiotis Sakarellos, Michail Vailas, Kevin N Shah, Alexandros Papalampros
INTRODUCTION: Retroperitoneal lymph node dissection (RPLND) in testicular cancer is a documented treatment along with active surveillance and chemotherapy. This study aims to summarize the current evidence on the use of Robot-assisted RPLND (RARPLND) in comparison with the laparoscopic and open approach. MATERIALS AND METHODS: A search was conducted in the existing literature focusing on reports with outcomes of RARPLND for stage I-IIB testicular tumor. RESULTS: Eleven studies complied with the inclusion criteria, including 116 patients...
February 23, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29410311/clinical-outcome-of-retroperitoneal-lymph-node-dissection-after-chemotherapy-in-patients-with-pure-embryonal-carcinoma-in-the-orchiectomy-specimen
#10
Catherine M Dowling, Melissa Assel, John E Musser, Joshua J Meeks, Daniel D Sjoberg, George Bosl, Robert Motzer, Dean Bajorin, Darren Feldman, Brett S Carver, Joel Sheinfeld
OBJECTIVE: To determine the pathologic findings and clinical outcome of patients with pure embryonal carcinoma (EC) of the testis who were diagnosed with testis cancer from January 1989 to January 2013 who underwent an orchiectomy, cisplatin-based chemotherapy and a postchemotherapy retroperitoneal lymph node dissection (PC-RPLND). METHODS: We compared those patients with 100% EC with those with mixed nonseminomatous germ cell tumor pathology who underwent a PC-RPLND...
April 2018: Urology
https://www.readbyqxmd.com/read/29387987/detailed-pathologic-analysis-on-the-co-occurrence-of-non-seminomatous-germ-cell-tumor-subtypes-in-matched-orchiectomy-and-retroperitoneal-lymph-node-dissections
#11
Daniel E Spratt, Krithika Suresh, Takahiro Osawa, Matthew Schipper, William C Jackson, Ahmed Abugharib, Amir Lebastchi, David Smith, Jeffrey S Montgomery, Ganesh S Palapattu, L Priya Kunju, Angela Wu, Madelyn Lew, Scott A Tomlins, Arul M Chinnaiyan, Alon Z Weizer, Khaled S Hafez, Samuel D Kaffenberger, Aaron Udager, Rohit Mehra
The frequency of co-occurrence between germ cell tumor (GCT) components in non-seminomatous germ cell tumor (NSGCT) orchiectomy specimens and their correlation with histologic findings in subsequent retroperitoneal lymph node dissection (RPLND) specimens have not been well characterized. The objective of the study was to report the first detailed clinicopathologic analysis of NSGCT orchiectomy and RPLND samples to determine the likelihood and agreement of the co-occurrence of GCT components. A total of 118 consecutive patients with NSGCT treated between 1988 and 2012 who underwent both orchiectomy and RPLND at a single academic tertiary care center were analyzed...
January 31, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29382456/a-contemporary-population-based-study-of-testicular-sex-cord-stromal-tumours-presentation-treatment-patterns-and-predictors-of-outcome
#12
Lindsay M Yuh, Primo N Lara, Rebecca M Wagenaar, Christopher P Evans, Marc A Dall'era, Rosemary Cress, Stanley A Yap
INTRODUCTION: We aimed to characterize demographic distribution, patient outcomes, and prognostic features of testicular sex cord stromal tumours (SCST) using a large statewide database. METHODS: Adult male patients diagnosed with SCST between 1988 and 2010 were identified within the California Cancer Registry (CCR). Baseline demographic variables and disease characteristics were reported. Primary outcome measures were cancer-specific survival (CSS) and overall survival (OS)...
September 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29353314/robot-assisted-post-chemotherapy-retroperitoneal-lymph-node-dissection-in-germ-cell-tumor-is-the-single-docking-with-lateral-approach-relevant
#13
C Overs, J B Beauval, L Mourey, P Rischmann, M Soulié, M Roumiguié, Nicolas Doumerc
INTRODUCTION: Surgical treatment of post-chemotherapy residual mass of germ cell tumor (GCT) may be performed in various techniques. We assess the feasibility, safety, and efficacy of single-docking with lateral approach robot-assisted retroperitoneal lymph node dissection (R-RPLND) in residual mass of GCT in our center. MATERIALS AND METHODS: A retrospective review of patients undergoing R-RPLND for residual mass of CGT was performed between January 2014 and April 2017...
April 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29245261/extraperitoneal-robot-assisted-laparoscopic-retroperitoneal-lymph-node-dissection-for-early-stage-testicular-nonseminomatous-germ-cell-tumors-a-case-report-and-literature-review
#14
REVIEW
Jie Qin, Ping Wang, Taile Jing, Debo Kong, Dan Xia, Shuo Wang
RATIONALE: Typically robot-assisted laparoscopic retroperitoneal lymph node dissection (R-RPLND) has been performed via a transperitoneal approach. Herein we report the first case of a novel R-RPLND using an extraperitoneal approach. PATIENT CONCERNS: A 38-year-old man presented with an enlarging right scrotal mass. DIAGNOSES: Scrotal ultrasonography demonstrated a 5.5-cm solid mass of the right testis. The patient underwent right radical inguinal orchiectomy...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29215949/laparoscopic-retroperitoneal-lymph-node-dissection-as-a-safe-procedure-for-postchemotherapy-residual-mass-in-testicular-cancer
#15
Eliney Ferreira Faria, Hugo Silva Neves, Breno Dauster, Roberto Dias Machado, Wesley Justino Magnabosco, Roberto Lodeiro Muller, Alexandre César Santos, Marcos Tobias-Machado
BACKGROUND: To evaluate the feasibility, clinical and perioperative outcomes of laparoscopic retroperitoneal lymph node dissection (L-RPLND) in the management of patients with germ cell tumors (GCT) and residual post-chemotherapy mass. METHODS: We report our experience of 25 patients treated with L-RPLND between 2008 and 2015. All 25 patients were diagnosed with GCT by primary pathological evaluation of the specimens after orchiectomy. All patients received cisplatin-based chemotherapy...
February 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29158173/standardized-and-simplified-retroperitoneal-lymph-node-dissection-during-retroperitoneal-laparoscopic-radical-nephroureterectomy-for-urothelial-carcinoma-of-the-upper-ureter-or-renal-pelvis-en-bloc-resection-technique
#16
Toru Kanno, Go Kobori, Masashi Kubota, Satoshi Funada, Takao Haitani, Takashi Okada, Yoshihito Higashi, Seiji Moroi, Hitoshi Yamada
OBJECTIVE: To describe our en bloc technique of retroperitoneal lymph node dissection (RPLND) during retroperitoneal laparoscopic radical nephroureterectomy for upper urinary tract urothelial carcinoma and evaluate perioperative outcomes. METHODS: From 2002 to 2015, 114 patients with urinary tract urothelial carcinoma located at the pelvis or upper or middle ureter underwent retroperitoneal laparoscopic radical nephroureterectomy at 2 institutions. Performance of RPLND began in February 2009...
February 2018: Urology
https://www.readbyqxmd.com/read/29135122/the-role-of-the-multidisciplinary-team-in-the-decision-making-process-in-stage-one-testicular-cancer-retrospective-cohort-analysis
#17
Tomislav Omrcen, Andrija Katic, Eduard Vrdoljak
PURPOSE: To analyze the role of a multidisciplinary team (MDT) in the decision-making process in clinical stage one (CS I) testicular cancer (TC). METHODS: We retrospectively evaluated data on 115 consecutive patients with CS I TC (excluding stage IS) who were referred to the Department of Oncology, University Hospital of Split, Croatia, from 2003 to 2012. Fifty-six patients (48.7%) were referred between 2003 and 2007, before the introduction of the MDT and 59 patients (51...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29129354/surgical-management-and-outcomes-of-patients-with-bone-metastases-in-germ-cell-tumors-a-case-series
#18
Alessandro Nini, Marcus Konieczny, Christian Winter, Achim Lusch, Rüdiger Krauspe, Peter Albers
OBJECTIVE: To report perioperative and oncological outcomes of patients with nodal and bone involvement treated with postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) and simultaneous bone resection (BR). PATIENTS AND METHODS: Between 2008 and 2016, 14 consecutive unselected TC patients with nodal and bone involvement underwent PC-RPLND and BR. Surgery was performed together with orthopedic surgeons. Standard PC-RPLNDs were performed in 4 patients...
February 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29104087/long-term-survival-of-good-risk-germ-cell-tumor-patients-after-postchemotherapy-retroperitoneal-lymph-node-dissection-a-comparison-of-bep%C3%A2-%C3%A3-3-vs-ep%C3%A2-%C3%A3-4-and-treating-institution
#19
Clint Cary, Joseph M Jacob, Costantine Albany, Timothy A Masterson, Nasser H Hanna, Lawrence H Einhorn, Richard S Foster
BACKGROUND: Patients with International Germ Cell Cancer Collaborative Group (IGCCCG) good-risk testicular cancer might receive either 4 cycles of etoposide and cisplatin (EP × 4) or 3 cycles of bleomycin, etoposide, and cisplatin (BEP × 3). We sought to examine differences in survival after retroperitoneal lymph node dissection (PC-RPLND) between patients who received EP × 4 compared with BEP × 3. PATIENTS AND METHODS: The Indiana University Testis Cancer database was queried to identify IGCCCG good-risk PC-RPLND patients who received either EP × 4 or BEP × 3 induction chemotherapy...
October 16, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29026972/retroperitoneal-lymph-node-dissection-for-testicular-seminomas-population-based-practice-and-survival-outcomes
#20
Hiten D Patel, Gregory A Joice, Zeyad R Schwen, Alice Semerjian, Ridwan Alam, Arnav Srivastava, Mohamad E Allaf, Phillip M Pierorazio
PURPOSE: While retroperitoneal lymph node dissection (RPLND) is traditionally reserved for nonseminomatous germ cell tumors, recent efforts to reduce long-term toxicities of radiation and chemotherapy have turned attention to its application for testicular seminomas. Currently, RPLND is reserved for the post-chemotherapy for stage II testicular seminomas; we aimed to describe current utilization of RPNLD for testicular seminomas by stage and implications for survival. METHODS: A national sample of men diagnosed with stage IA/IB/IS/IIA/IIB/IIC testicular seminoma (1988-2013) was evaluated from SEER Program registries...
January 2018: World Journal of Urology
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