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heavy menstrual bleeding

X Yao, E A Stewart, S K Laughlin-Tommaso, H C Heien, B J Borah
OBJECTIVES: To report patterns and patient characteristics associated with initiation of and persistence with medical therapies for uterine fibroid-related heavy menstrual bleeding. DESIGN: Retrospective cohort study. SETTING: US commercial insurance claims database. POPULATION: 41 561 women aged 18-54 years with uterine fibroids and heavy menstrual bleeding who initiated medical therapies from January 2000 through December 2013...
October 21, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
M E Pennant, R Mehta, P Moody, G Hackett, A Prentice, S J Sharp, R Lakshman
BACKGROUND: Endometrial biopsies are undertaken in premenopausal women with abnormal uterine bleeding but the risk of endometrial cancer or atypical hyperplasia is unclear. OBJECTIVES: To conduct a systematic literature review to establish the risk of endometrial cancer and atypical hyperplasia in premenopausal women with abnormal uterine bleeding. SEARCH STRATEGY: Search of PubMed, Embase and the Cochrane Library from database inception to August 2015...
October 20, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
J E Dietrich, D L Yee, X M Santos, J L Bercaw-Pratt, J Kurkowski, H Soni, Y J Lee-Kim, M D Shah, D Mahoney, L V Srivaths
BACKGROUND: Bleeding disorders (BD) occur in up to 50% of adolescents with heavy menstrual bleeding (HMB). This presents unique challenges to healthcare providers given the complexity of treating the condition and such complexity can result in difficulty with patients understanding basic information about their condition, limit communication with medical providers, and patient compliance. SPECIFIC AIMS: To use an electronic approach to enhance patient compliance with medications used to treat their HMB...
October 14, 2016: Journal of Pediatric and Adolescent Gynecology
Karin S Coyne, Ahmed M Soliman, Mary Kay Margolis, Christine L Thompson, Kristof Chwalisz
OBJECTIVE: To assess the psychometric performance of the 4-week recall version of the Uterine Fibroid Symptom and Health-related Quality of Life Questionnaire (UFS-QoL), a patient measure of the severity of uterine fibroid (UF) symptoms and their impact on health-related quality of life (HRQL). METHODS: This was a retrospective analysis of Phase 2a data from pre-menopausal women with heavy menstrual bleeding associated with UF. Participants completed the UFS-QoL at Baseline, Treatment Month 3, and Follow-up Month 3 and a daily diary with a Menstrual Bleeding Scale and the UF Daily Symptom Scale throughout the study duration...
October 13, 2016: Current Medical Research and Opinion
Deborah Bateson, Caroline Harvey, Lieu Trinh, Mary Stewart, Kirsten I Black
BACKGROUND: Copper intrauterine device (Cu-IUD) use in Australia is low despite being a highly effective, cost effective non-hormonal contraceptive with reported 12-month continuation rates of 85% compared to 59% for oral contraception. AIMS: To describe the characteristics of Cu-IUD users in the Australian context, their experiences of side effects, continuation rates and reasons for discontinuation. METHODS: Between August 2009 and January 2012 we undertook a prospective cohort study of consecutive women presenting for Cu-IUD insertion to three family planning clinics in Queensland and New South Wales...
October 5, 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
Valentina Shaw, Alain C Vandal, Christin Coomarasamy, Alec J Ekeroma
INTRODUCTION: To evaluate the effectiveness of the levonorgestrel intrauterine system (LNG-IUS) in obese women with heavy menstrual bleeding in Counties Manukau Auckland area, New Zealand. METHODS: Prospective observational study in a tertiary teaching hospital. Twenty women with heavy menstrual bleeding (HMB) who agreed to treatment with the LNG-IUS and had a body mass index (BMI) of >30 kg/m(2) were recruited between May and December 2014. The women completed two validated tools (Menstrual Impact Questionnaire and the Pictorial Bleeding Assessment Chart) at recruitment, 6 and 12 months follow-up...
October 3, 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
Jan Beyer-Westendorf, Franziska Michalski, Luise Tittl, Susann Hauswald-Dörschel, Sandra Marten
BACKGROUND: Observational data and results from post-hoc analyses in clinical trials suggest that direct oral factor Xa inhibitors might increase menstrual bleeding intensity in women of reproductive age, but the extent of this effect is unknown. We aimed to investigate the management and outcomes of vaginal bleeding complications during therapy with direct oral factor Xa inhibitors in a case series of women of reproductive age. METHODS: To identify individuals for inclusion in this case series, we searched two sources of prospectively collected data from women of reproductive age treated with direct oral factor Xa inhibitors: the non-interventional Dresden NOAC Registry (NCT01588119), which is based in the administrative district of Dresden (Saxony, Germany), and all locally archived data from phase 3 trials of direct oral factor Xa inhibitors done at University Hospital Carl Gustav Carus Dresden...
October 2016: Lancet Haematology
Philippe Laberge, Jose Garza-Leal, Claude Fortin, David Grainger, Delbert Alan Johns, Royce T Adkins, James Presthus, Cindy Basinski, Monte Swarup, Richard Gimpelson, Nicholas Leyland, John Thiel, Micah Harris, Pamela E Burnett, Gene F Ray
STUDY OBJECTIVE: To assess the safety and effectiveness of the Minerva Endometrial Ablation System for the treatment of heavy menstrual bleeding in pre-menopausal women. DESIGN: Multi-center, randomized, controlled, international study. Canadian Task Force Classification I. SETTING: 13 academic and private medical centers. PATIENTS: 153 pre-menopausal women suffering from Heavy Menstrual Bleeding (PALM-COEIN: E,O). INTERVENTION: Patients were treated using the Minerva Endometrial Ablation System or rollerball ablation...
September 26, 2016: Journal of Minimally Invasive Gynecology
A Oraif, J Smith, G A Vilos, A G Vilos, H Abduljabar, J Hollett-Caines
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Nicola Brodie, Elizabeth A Silberholz, Nancy D Spector, Amy E Pattishall
PURPOSE OF REVIEW: The present article addresses recent research related to three key facets of adolescent preventive care and health maintenance: long-acting reversible contraception, human papillomavirus vaccination, and heavy menstrual bleeding. RECENT FINDINGS: Recent studies suggest that long-acting reversible contraception use results in significantly lower rates of unintended pregnancies, and is well tolerated by nulliparous adolescent females. Additionally, a strong recommendation from a pediatric primary care provider is extremely effective in ensuring human papillomavirus vaccination prior to sexual debut...
September 26, 2016: Current Opinion in Pediatrics
Georgy Joy Eralil
OBJECTIVE: Levonorgestrel-releasing intrauterine system (LNG-IUS) has been shown to be an effective treatment for patients with abnormal uterine bleeding (AUB) in many Western studies. The purpose of study was to examine the effectiveness of LNG-IUS in the treatment of Indian women with AUB. METHODS: We conducted a retrospective observational study of 70 women diagnosed with AUB and treated with LNG-IUS insertion between February 2010 and 2014 at the Department of Gynecology of Sree Narayana Institute of Medical Sciences...
October 2016: Journal of Obstetrics and Gynaecology of India
Luis Bahamondes, Victor Marin, Silvia Ciarmatori, Agnaldo L Silva-Filho, Juan Manuel Acuña, Maria Y Makuch
Background. Heavy menstrual bleeding (HMB) is a common gynecological complaint affecting quality of life. Objectives. To assess knowledge on diagnosis and treatments of HMB of Latin American (LA) obstetricians and gynecologists (OBGYNs). Methods. A survey was conducted during a scientific meeting, organized to provide updated information on topics of reproductive medicine to OBGYNs from 12 LA countries who were invited to respond to a multiple-choice questionnaire. Results. Of the 210 OBGYNs participating in the survey, from 169 (80...
2016: Obstetrics and Gynecology International
Helena Kopp Kallner, Kristina Gemzell Danielsson
Preservation of fertility and optimizing health before pregnancy is becoming increasingly important in societies where childbirth often is postponed. Research shows that as women postpone childbirth they achieve higher levels of education and higher incomes. This leads to advantages for their children and for society. However, as women postpone childbearing they are at risk for contracting conditions which may affect fertility and/or pregnancies, pregnancy outcome, and the newborn child. Preconception counseling is therefore becoming increasingly important...
September 20, 2016: Upsala Journal of Medical Sciences
William T Gunning, Beverly L Karabin, Thomas M Blomquist, Blair P Grubb
Mechanisms have been postulated to explain postural orthostatic tachycardia syndrome (POTS), however, the etiology of this often debilitating disorder remains unknown. We conducted a retrospective case-control study of 181 POTS patients who exhibited/reported bleeding symptoms for a specific platelet (PL) dysfunction disorder, delta granule storage pool deficiency (δ-SPD).Patients were included only if results of blood tests for δ-SPD were available. Electron microscopy was utilized to diagnose δ-SPD. An ELISA assay was used to determine serotonin (5HT) concentration in PLs and medical record review was employed to collect patients' clinical symptoms...
September 2016: Medicine (Baltimore)
Edith Weisberg, Kevin McGeehan, Ian S Fraser
OBJECTIVES: The aim of the study was to explore Australian women's experiences of menstruation and effect on quality of life (QoL). METHODS: A representative sample of women recruited through a commercial social research sampling organisation completed a detailed online questionnaire about menstruation. Specific detailed questions were asked about perceptions of heavy menstrual bleeding (HMB) and menstrual pain. RESULTS: The questionnaire was completed by 1575 women aged 20-39 years...
September 13, 2016: European Journal of Contraception & Reproductive Health Care
Sabrina N Wyatt, Taylor Banahan, Ying Tang, Kavita Nadendla, Jeff M Szychowski, Todd R Jenkins
STUDY OBJECTIVE: To examine rates of dysmenorrhea after radiofrequency endometrial ablation in patients with and without known dysmenorrhea symptoms prior to the procedure in a diverse population. DESIGN: Retrospective Cohort study; DESIGN: Classification: Retrospective Cohort Study (Canadian Task Force Classification II-2); SETTING: Academic gynecology practice PATIENTS: 307 women underwent endometrial ablation from 2007 to 2013 at our institution. Patients who had preoperative and postoperative pain symptom assessments recorded as well as a description of pain timing were included...
August 30, 2016: Journal of Minimally Invasive Gynecology
Prachi Jain, Shalini Rajaram, Bindiya Gupta, Neerja Goel, Himsweta Srivastava
OBJECTIVE: To compare the efficacy of thermal balloon ablation (TBA) with that of vaginal hysterectomy in the treatment of leiomyoma-induced heavy menstrual bleeding (HMB). METHODS: An open-label randomized controlled trial was conducted between November 1, 2012, and October 31, 2014, in a tertiary care hospital in Delhi, India. Eligible women with HMB (aged ≥40 years, uterus size ≤14 weeks of pregnancy, leiomyoma ≤5 cm, uterocervical length ≤12 cm) were randomly assigned (1:1) to undergo TBA or vaginal hysterectomy using computer-generated random number tables...
November 2016: International Journal of Gynaecology and Obstetrics
Dirk Wildemeersch, Amaury Andrade, Norman Goldstuck
OBJECTIVE: The aim of this study was to update the clinical experience with the Femilis® 60 levonorgestrel-releasing intrauterine system (LNG-IUS), now up to 10 years in parous and nulliparous women, particularly with regard to ease and safety of insertion, contraceptive performance, retention, acceptability, continuation of use, impact on menstrual blood loss (MBL), and duration of action. STUDY DESIGN: Using the Femilis® 60 LNG-IUS releasing 20 µg of levonorgestrel/day, the following studies were conducted: an open, prospective noncomparative contraceptive study, an MBL study, a perimenopausal study, a study for the treatment of endometrial hyperplasia, and early cancer of the uterus, a residue study...
2016: Clinical Medicine Insights. Reproductive Health
Lia A Bernardi, Marissa S Ghant, Carolina Andrade, Hannah Recht, Erica E Marsh
BACKGROUND: Both iron deficiency and iron deficiency anemia are common in the United States with a prevalence amongst women of 12 % and 4 % respectively. These numbers are even higher in African-American women (AAW) and are often a result of heavy menstrual bleeding (HMB). The primary objective of this study was to determine if perceived assessment of menstrual bleeding was associated with objective and subjective measures of anemia in AAW. METHODS: Quantitative cross-sectional pilot study with surveys and venipuncture...
2016: BMC Women's Health
Ahmad Abu Sulb, Marwa Abu El Haija, Akila Muthukumar
Pelvic tumors in adolescent females are very uncommon. While the most common presentation is pelvic discomfort, we report the case of a 14-year-old female presenting with menorrhagia which is an unusual initial complaint for a large pelvic tumor. Adolescent females who present with heavy menstrual bleeding initially undergo assessment to rule out a bleeding disorder. In this case, careful history and physical examination helped in making a quick diagnosis and management. Ultrasound of abdomen showed a huge cystic mass due to serous cystadenoma of the ovary...
2016: SAGE Open Med Case Rep
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