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https://www.readbyqxmd.com/read/29889874/investigating-the-loss-of-work-productivity-due-to-symptomatic-leiomyoma
#1
Klara Hasselrot, Mia Lindeberg, Peter Konings, Helena Kopp Kallner
INTRODUCTION: Leiomyoma affects up to 50% of fertile women, leading to morbidity such as bleeding or pain. The effect of symptomatic leiomyoma on the productivity of employed women is understudied. The present study investigates productivity loss in a Swedish setting in women with symptomatic leiomyoma compared to healthy women. MATERIAL AND METHODS: Women seeking care for leiomyoma and heavy menstrual bleeding (HMB) were recruited at nine Swedish sites. Healthy controls with self-perceived mild to normal menstruation were recruited at routine visits...
2018: PloS One
https://www.readbyqxmd.com/read/29871715/systemic-iron-deficiency-in-a-nonhuman-primate-model-of-endometriosis
#2
Hannah M Atkins, Susan E Appt, Robert N Taylor, Yaritbel Torres-Mendoza, Emily E Lenk, Nancy S Rosenthal, David L Caudell
Endometriosis is characterized by endometrial tissue development outside the uterus. Anemia and iron depletion do notcommonly accompany endometriosis in women, despite chronic abdominal inflammation and heavy menstrual bleeding.The objective of this study was to examine iron kinetics associated with endometriosis by using a NHP model, to betterunderstand the underlying mechanism of abnormal hematogram values in women with endometriosis. Hematologic datafrom 46 macaques with endometriosis were examined for signs of iron depletion...
June 5, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29852335/epidemiology-of-uterine-myomas-and-clinical-practice-in-spain-an-observational-study
#3
Javier Monleón, María Luisa Cañete, Virginia Caballero, Manuel Del Campo, Alejandro Doménech, Miguel Ángel Losada, Joaquim Calaf
OBJECTIVE: Characterization of the clinical features of symptomatic uterine myomas in Spanish women visiting the gynaecologist, including impact on quality of life and possible risk factors, description of main therapeutic approaches, and evaluation of symptom and quality of life progression 6 months after inclusion in the study. STUDY DESIGN: This was an observational, epidemiological, non-interventional, multicentre study performed between June 2015 and March 2016...
May 21, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29848416/outcome-of-total-laparoscopic-hysterectomy
#4
Samina Saleem Dojki, Alia Bano
OBJECTIVE: To determine the surgical outcomes of total laparoscopic hysterectomy performed. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Obstetrics and Gynecologic Endoscopic Unit of Patel Hospital, Karachi, from February 2013 till February 2016. METHODOLOGY: The study included all patients on whom total laparoscopic hysterectomy was performed during the study period. Patients with malignancy were excluded from the study, except those with suspected stage 1 and 2 endometrial carcinoma...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29803622/extreme-anemia-hb-33-g-l-in-a-13-year-old-girl-is-the-transfusion-always-mandatory
#5
Ivo Beverina, Patrizia Macellaro, Luciana Parola, Bruno Brando
Iron-deficiency anemia is a frequent condition in women and adolescent girls often caused by heavy menstrual bleeding. Sometimes the level of chronic anemia, although well tolerated, can be very severe. The recently introduced Patient Blood Management guidelines and the availability of effective and safe intravenous iron preparations may question transfusion as the traditional option. We describe here the case of a 13 years old girl with extreme iron-deficiency chronic anemia (Hb 33 g/L) that was successfully treated with i...
May 19, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29780819/a-comprehensive-review-of-the-pharmacologic-management-of-uterine-leiomyoma
#6
REVIEW
Terrence D Lewis, Minnie Malik, Joy Britten, Angelo Macapagal San Pablo, William H Catherino
Uterine leiomyomata are the most common benign tumors of the gynecologic tract impacting up to 80% of women by 50 years of age. It is well established that these tumors are the leading cause for hysterectomy with an estimated total financial burden greater than $30 billion per year in the United States. However, for the woman who desires future fertility or is a poor surgical candidate, definitive management with hysterectomy is not an optimal management plan. Typical gynecologic symptoms of leiomyoma include infertility, abnormal uterine bleeding (AUB)/heavy menstrual bleeding (HMB) and/or intermenstrual bleeding (IMB) with resulting iron-deficiency anemia, pelvic pressure and pain, urinary incontinence, and dysmenorrhea...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29777604/-ethical-aspects-of-the-use-of-mirena-r-iud-in-the-treatment-of-heavy-menstrual-bleeding
#7
Miriam Turiel Miranda, Pau Agulles Simó
The levonorgestrel-releasing intrauterine device known as Mirena IUD(r) (20mcg/24h) is nowadays considered among the leading resources in the treatment of heavy menstrual bleeding. Nonetheless, due to either its effect of prevention of conception and especially to the possibility that it may also have an anti-implantation effect, there is a founded concern on whether its therapeutic use may be ethically licit. This article engages in an exhaustive literature review in order to ascertain the mechanism of action of Mirena(r) IUD, in view of an ethical evaluation of its therapeutic use, keeping in mind those two unwanted effects...
May 2018: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/29772408/hysteroscopic-myomectomy-of-a-large-submucosal-leiomyoma-with-novel-use-of-fluid-warming
#8
Tess Chase, Stephanie J Estes
Uterine fibroid size is often considered a limiting factor for considering the surgical approach to myomectomy. In this case, a 35-year-old woman presented with heavy menstrual bleeding and desire for fertility. An ultrasound three months prior could not assess the endometrium and suggested leiomyoma. Magnetic resonance imaging of the pelvis identified a fundal submucosal myoma measuring 6.8 × 7.1 × 3.5 cm. A planned staged hysteroscopic resection of the large submucosal fibroid with intramural component was achieved...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29770717/treatment-patterns-and-health-care-resource-utilization-and-costs-in-heavy-menstrual-bleeding-a-japanese-claims-database-analysis
#9
Sayako Akiyama, Erika Tanaka, Olivier Cristeau, Yoshie Onishi, Yutaka Osuga
AIMS: Heavy menstrual bleeding (HMB) is a highly prevalent condition characterized by excessive menstrual blood loss and cramping that interferes with activities of daily life. The aim of our study was to investigate treatment patterns in HMB in Japan, and to assess healthcare resource utilization and costs among women newly diagnosed with the condition. MATERIALS AND METHODS: We retrospectively analysed health insurance data available in the Japan Medical Data Center (JMDC) database on women aged 18-49 years who were newly diagnosed with primary or secondary HMB...
May 17, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29746814/a-case-series-on-the-use-of-levonorgestrel-52mg-intrauterine-system-after-organ-transplant
#10
Cassia R T Juliato, Paulo Stahlscmidt, Arlete Fernandes, Ilza Monteiro, Luis Bahamondes
OBJECTIVE: To assess the clinical performance (pregnancy and occurrence of pelvic infection) of the levonorgestrel 52-mg intrauterine system (LNG IUS) in solid organ transplant recipients. STUDY DESIGN: We performed a retrospective chart review of all patients seen in the Family Planning Clinic at the University of Campinas Department of Obstetrics and Gynecology from 2007-2017 to identify women with solid organ transplantation using immunosuppression who received a LNG- IUS...
May 7, 2018: Contraception
https://www.readbyqxmd.com/read/29742662/patterns-of-von-willebrand-disease-screening-in-girls-and-adolescents-with-heavy-menstrual-bleeding
#11
Amanda E Jacobson, Sara K Vesely, Terah Koch, Janis Campbell, Sarah H OʼBrien
OBJECTIVE: To estimate the frequency of von Willebrand disease screening and factors that affect screening frequency in a national sample of girls and adolescents with heavy menstrual bleeding. METHODS: In this retrospective cohort study, we used a national claims database for privately and publicly insured patients between 2011 and 2013 for girls aged 10-17 years. Diagnostic criteria of heavy menstrual bleeding were the presence of one inpatient or two outpatient International Classification of Diseases, 9th Revision codes for heavy menstrual bleeding...
June 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29731212/no-292-abnormal-uterine-bleeding-in-pre-menopausal-women
#12
Sukhbir Singh, Carolyn Best, Sheila Dunn, Nicholas Leyland, Wendy Lynn Wolfman
BACKGROUND: Abnormal uterine bleeding is the direct cause of a significant health care burden for women, their families, and society as a whole. Up to 30% of women will seek medical assistance for this problem during their reproductive years. This guideline replaces previous clinical guidelines on the topic and is aimed to enable health care providers with the tools to provide the latest evidence-based care in the diagnosis and the medical and surgical management of this common problem...
May 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29714438/is-thermal-balloon-ablation-in-women-with-previous-cesarean-delivery-successful
#13
Zinatossadat Bouzari, Shahla Yazdani, Mojgan Naeimi Rad, Ali Bijani
Background/aim: Endometrial ablation is used to treat heavy menstrual bleeding in women who do not respond to standard therapy. This study aimed to compare treatment success in women with previous cesarean delivery and vaginal delivery who were subjected to thermal balloon ablation. Materials and methods: This cohort study enrolled women with symptoms of heavy menstrual bleeding who had major health problems and were considered as high-risk patients for hysterectomy. Patients were divided into two groups, vaginal delivery and cesarean section (C-section)...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29708902/the-case-against-endometrial-ablation-for-treatment-of-heavy-menstrual-bleeding
#14
Michelle Louie, Kelly Wright, Matthew Siedhoff
PURPOSE OF REVIEW: Endometrial ablation is a common treatment for heavy menstrual bleeding, but serious limitations and long-term complications exist. Our purpose is to summarize the use of endometrial ablation devices, potential short-term and long-term complications, cost effectiveness, and quality of life in relation to alternative treatments. RECENT FINDINGS: There is insufficient evidence to strongly recommend one endometrial ablation device over another. Providers should consider and discuss with their patients, complications including risk of future pregnancy, endometrial cancer, and hysterectomy for continued bleeding or pain...
April 27, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29706284/ulipristal-acetate-for-the-management-of-large-uterine-fibroids-associated-with-heavy-bleeding-a-review
#15
REVIEW
Jacques Donnez, Guillaume E Courtoy, Olivier Donnez, Marie-Madeleine Dolmans
Ulipristal acetate (UPA), a selective progesterone receptor modulator (SPRM), offers new therapeutic options for the clinical management of large uterine fibroids associated with heavy menstrual bleeding or with other moderate or severe symptoms (bulk symptoms, pelvic pain, decreased quality of life). SPRM are synthetic compounds that exert an agonist or antagonist effect on target tissues by their binding to progesterone receptors. UPA reduces fibroid size, controls bleeding in a high percentage of women and significantly improves quality of life...
April 21, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29656433/antifibrinolytics-for-heavy-menstrual-bleeding
#16
REVIEW
Alison C Bryant-Smith, Anne Lethaby, Cindy Farquhar, Martha Hickey
BACKGROUND: Heavy menstrual bleeding (HMB) is an important physical and social problem for women. Oral treatment for HMB includes antifibrinolytic drugs, which are designed to reduce bleeding by inhibiting clot-dissolving enzymes in the endometrium.Historically, there has been some concern that using the antifibrinolytic tranexamic acid (TXA) for HMB may increase the risk of venous thromboembolic disease. This is an umbrella term for deep venous thrombosis (blood clots in the blood vessels in the legs) and pulmonary emboli (blood clots in the blood vessels in the lungs)...
April 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29655581/paternal-understanding-of-menstrual-concerns-in-young-women
#17
Jane E Girling, Samuel C J Hawthorne, Jennifer L Marino, Abdul G Nur Azurah, Sonia R Grover, Yasmin L Jayasinghe
STUDY OBJECTIVE: No studies have specifically considered paternal understanding of menstruation. This study aimed to establish the degree of understanding of fathers of adolescent girls with menstrual symptoms relative to mothers. DESIGN AND SETTING: This was a cross-sectional survey-based study. Adolescent patients attending an outpatient gynecology clinic for dysmenorrhea and/or heavy menstrual bleeding and their parents were invited to complete surveys. PARTICIPANTS: Sixty surveys were completed (24 of 40 daughters, 20 of 40 mothers, 16 of 40 fathers)...
April 12, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29628726/abnormal-uterine-bleeding-evaluation-by-endometrial-aspiration
#18
Pratibha Singh
Endometrial evaluation is generally indicated in cases presenting with abnormal uterine bleeding (AUB), especially in women more than 35 years of age. AUB encompasses a variety of presentation, for example, heavy menstrual bleeding, frequent bleeding, irregular vaginal bleeding, postcoital and postmenopausal bleeding to name a few. Many methods are used for the evaluation of such cases, with most common being sonography and endometrial biopsy with very few cases requiring more invasive approach like hysteroscopy...
January 2018: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29606892/management-of-abnormal-uterine-bleeding-focus-on-ambulatory-hysteroscopy
#19
REVIEW
Shilpa Kolhe
The rapid evolution in ambulatory hysteroscopy (AH) has transformed the approach to diagnose and manage abnormal uterine bleeding (AUB). The medical management in primary care remains the mainstay for initial treatment of this common presentation; however, many women are referred to secondary care for further evaluation. To confirm the diagnosis of suspected intrauterine pathology, the traditional diagnostic tool of day case hysteroscopy and dilatation and curettage in a hospital setting under general anesthesia is now no longer required...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29596075/managing-heavy-menstrual-bleeding-in-women-at-risk-of-thrombosis
#20
Andrew Rivara, Andra H James
Management of heavy menstrual bleeding (HMB) in a woman with a history of thrombosis, or who is otherwise at high risk of thrombosis, or who takes medications for anticoagulation can present a challenge to health care providers. The goal of treating HMB is to reduce menstrual blood loss. First-line therapy is typically hormonal, and hormonal therapy can be contraindicated in women with a history of thrombosis unless they are on anticoagulation. As 70% of women on anticoagulation experience HMB, successful management of HMB may involve a modification in the anticoagulation or antiplatelet regimen, hormonal therapy tailored to the patient's situation, and/or surgical therapy...
June 2018: Clinical Obstetrics and Gynecology
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