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https://www.readbyqxmd.com/read/29924941/therapeutic-targeting-of-vascular-remodeling-and-right-heart-failure-in-pah-with-hif-2%C3%AE-inhibitor
#1
Zhiyu Dai, Maggie M Zhu, Yi Peng, Narsa Machireddy, Colin E Evans, Roberto Machado, Xianming Zhang, You-Yang Zhao
RATIONALE: Pulmonary arterial hypertension (PAH) is a devastating disease characterized by progressive vasoconstriction and obliterative vascular remodeling that leads to right heart failure (RHF) and death. Current therapies do not target vascular remodeling and RHF, and only result in modest improvement of morbidity and mortality. OBJECTIVE: To determine whether targeting HIF-2α with a HIF-2α-selective inhibitor could reverse PAH and RHF in different rodent PAH models...
June 20, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29924371/discrepancy-between-the-european-clinical-guidelines-and-myocardial-revascularization-in-patients-with-stable-coronary-artery-disease-in-russia
#2
Anton R Kiselev, Alexey S Korotin, Olga M Posnenkova, Yulia V Popova, Mikhail D Prokhorov, Vladimir I Gridnev
Objective: In European Society of Cardiology/European Association for Cardio-Thoracic Surgery (ESC/EACTS) guidelines, six indications have been proposed for making a decision on myocardial revascularization in patients with stable coronary artery disease (CAD). Our aim was to study a discrepancy between the actual clinical situation and ESC/EACTS indications on performing the revascularization in patients with CAD in Russia. Design and setting: We used retrospective clinical data on patients with stable CAD enrolled in the 2012-2015 Russian Registry of Hypertension, Coronary Artery Disease, and Chronic Heart Failure...
June 19, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29924033/is-the-mean-platelet-volume-a-predictive-marker-of-a-high-in-hospital-mortality-of-acute-cardiorenal-syndrome-patients-receiving-continuous-renal-replacement-therapy
#3
Junhui Li, Xiaohua Sheng, Dongsheng Cheng, Feng Wang, Guihua Jian, Yongguang Li, Tao Xu, Xiaoxia Wang, Ying Fan, Niansong Wang
A high mean platelet volume (MPV) level has been demonstrated to predict poor clinical outcomes in patients with cardiovascular disease. However, the relationship between MPV and mortality in patients with acute cardiorenal syndrome (ACRS) is unknown. Therefore, we investigated the predictive value of MPV for in-hospital mortality of patients with ACRS who received continuous renal replacement therapy (CRRT) in this study.We retrospectively analyzed the demographics, etiology, severity of illness, prognosis, and risk factors of ACRS patients who underwent CRRT in our hospital from January 2009 to December 2014...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923986/serelaxin-recombinant-human-relaxin-2-for-heart-failure-patients-a-systematic-review-and-meta-analysis
#4
Ling Yu, Lijuan Cao, Jing Sun, Zhongyi Li, Fengzhen Yao, Yabin Zhou
BACKGROUND: Serelaxin, recombinant human relaxin-2, is a hormone with vasodilatory and end-organ protective effects. Recently, it has been licensed to treat acute decompensated heart failure. Here, a systematic review and meta-analysis on randomized controlled trials (RCTs) was performed to assess the effect of serelaxin on mortality and dyspnea improvement in patients with heart failure. METHODS: RCTs comparing serelaxin treatment to other heart failure treatments were searched in PubMed, Embase, Cochrane Library, and ClinicalTrials...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923940/factors-associated-with-mechanical-ventilation-use-in-children-with-sickle-cell-disease-and-acute-chest-syndrome
#5
Takuto Takahashi, Yusuke Okubo, Maria A Pereda, Atsuhiko Handa, Scott Miller
OBJECTIVES: Acute chest syndrome is the leading cause of death in children with sickle cell disease and is generally due to respiratory failure. Epidemiologic factors for a need for mechanical ventilation in children with acute chest syndrome require further clarification. DESIGN: Retrospective observational study. SETTING: Nationally representative pediatric inpatient records in the United States by using the Kids' Inpatient Database for the years 2003, 2006, 2009, and 2012...
June 19, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29923934/adenosine-plasma-level-and-a2a-receptor-expression-in-patients-with-cardiogenic-shock
#6
Mélanie Gaubert, Marion Marlinge, François Kerbaul, Noemie Resseguier, Marc Laine, Jennifer Cautella, Charlotte Cordier, Benjamin Colomb, Nathalie Kipson, Franck Thuny, Giovanna Mottola, Emmanuel Fenouillet, Jean Ruf, Franck Paganelli, Régis Guieu, Laurent Bonello
OBJECTIVES: To investigate whether adenosine A2A receptors lead to vasodilation and positive inotropic function under stimulation and whether they play a role in the control of blood pressure in patients with cardiogenic shock. DESIGN: Prospective observational study. SETTING: Monocentric, Hopital Nord, Marseille, France. SUBJECTS: Patients with cardiogenic shock (n = 16), acute heart failure (n = 16), and acute myocardial infarction (n = 16)...
June 19, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29923888/human-myocardium-has-a-robust-%C3%AE-1a-subtype-adrenergic-receptor-inotropic-response
#7
Paul M L Janssen, Benjamin D Canan, Ahmet Kilic, Bryan A Whitson, Anthony J Baker
Recent studies report that a single subtype of α1-adrenergic receptor (α1-AR), the α1A-subtype, mediates robust cardioprotective effects in multiple experimental models of heart failure, suggesting that the α1A-subype is a potential therapeutic target for an agonist to treat heart failure. Moreover, we recently found that the α1A-subtype is present in human heart. The goal of this study was to assess the inotropic response mediated by the α1A-subtype in human myocardium, and to determine if the response is down-regulated in myocardium from failing human heart...
May 25, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29923351/endophilina2-protects-against-angiotensin-ii-induced-cardiac-hypertrophy-by-inhibiting-angiotensin-ii-type-1-receptor-trafficking-in-neonatal-rat-cardiomyocytes
#8
Yun Liu, Huan-Jia Shen, Xin-Qiu-Yue Wang, Hai-Qi Liu, Ling-Yun Zheng, Jian-Dong Luo
Cardiac hypertrophy is one of the major risk factors for chronic heart failure. The role of endophilinA2 (EndoA2) in clathrin-mediated endocytosis and clathrin-independent endocytosis is well documented. In the present study, we tested the hypothesis that EndoA2 protects against angiotensin II (Ang II)-induced cardiac hypertrophy by mediating intracellular angiotensin II type 1 receptor (AT1-R) trafficking in neonatal rat cardiomyocytes (NRCMs). Cardiac hypertrophy was evaluated by using cell surface area and quantitative RT-PCR (qPCR) analyses...
June 20, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29923339/cardiovascular-disease-in-diabetes-type-2-current-concepts
#9
REVIEW
A Rosengren
Type 2 diabetes is a major and accelerating public health challenge. Between 1980 and 2014, a period of just 35 years, the number of adults with diabetes globally is estimated to have increased from 108 million to 422 million, due not only to sharply rising obesity rates, but also to increasing population size, and longer life expectancy. The increase in numbers is due to an increasing prevalence of diabetes worldwide, increasing population size, and longer life expectancy. Overall, worldwide age-standardized adult diabetes prevalence doubled from 4...
June 20, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29923116/cardiospecific-deletion-of-%C3%AE-e-catenin-leads-to-heart-failure-and-lethality-in-mice
#10
Volodymyr V Balatskyi, Larysa L Macewicz, Ana-Maria Gan, Sergii V Goncharov, Paulina Pawelec, Georgiy V Portnichenko, Tetiana Yu Lapikova-Bryginska, Viktor O Navrulin, Victor E Dosenko, Adam Olichwier, Pawel Dobrzyn, Oksana O Piven
αE-catenin is a component of adherens junctions that link the cadherin-catenin complex to the actin cytoskeleton. The signaling function of this protein was recently revealed. In the present study, we investigated the role of αE-catenin in the pathogenesis of heart failure. We mated αE-catenin conditional knockout mice with αMHC-Cre mice and evaluated their mutant offspring. We found that αE-catenin knockout caused enlargement of the heart and atria, fibrosis, the upregulation of hypertrophic genes, and the dysregulation of fatty acid metabolism via the transcriptional activity of Yap and β-catenin...
June 20, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29923067/hypertensive-disorders-of-pregnancy-and-cardiovascular-diseases-current-knowledge-and-future-directions
#11
REVIEW
Thais Coutinho, Olabimpe Lamai, Kara Nerenberg
PURPOSE OF THE REVIEW: Cardiovascular diseases (CVDs) are the principal killers of women. In this review, we summarize data regarding CVD and mortality after hypertensive disorders of pregnancy (HDP), and highlight clinical, research and policy needs to mitigate this risk. RECENT FINDINGS: Robust data indicate that women with HDP have substantially higher risk of future CVD, with a 3.7-fold increase in the risk of chronic hypertension, a 4.2-fold increase in the risk of heart failure, an 81% increase in the risk of stroke, and double the risk of atrial arrhythmias, coronary heart disease, and mortality when compared to women with normotensive pregnancies...
June 19, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29923025/cannabinoids-for-treatment-of-ms-symptoms-state-of-the-evidence
#12
REVIEW
Jessica Rice, Michelle Cameron
PURPOSE OF REVIEW: Cannabis and cannabinoids have been used medically and recreationally for thousands of years and recently there has been a growing body of research in this area. With increased access now that medical marijuana is available in many jurisdictions, patients and providers want to know more about the evidence for benefits and risks of cannabinoid use. This paper provides an overview of the available cannabinoid-based formulations, a summary of the highest quality evidence for the use of cannabinoids for treating spasticity and pain associated with multiple sclerosis (MS), and a discussion of possible dosing regimens based on information from these studies...
June 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29922881/cardiotoxicity-of-novel-targeted-chemotherapeutic-agents
#13
REVIEW
Isaac B Rhea, Guilherme H Oliveira
PURPOSE OF REVIEW: With the continuing development of newer targeted therapies in oncology, it is necessary to understand their potential cardiovascular side effects. In this review, we discuss the association of novel targeted agents and left ventricular systolic dysfunction. RECENT FINDINGS: Within the last 5 years, multiple new agents have been developed to target specific cancer pathways and found to have off-targeted cardiotoxicity. The most recent example is the recognition of myocarditis caused by immune checkpoint inhibitors...
June 19, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29922406/early-outcomes-after-carotid-endarterectomy-and-carotid-artery-stenting-for-carotid-stenosis-in-the-acs-nsqip-database
#14
Mohammed Alhaidar, Mohanad Algaeed, Richard Amdur, Rami Algahtani, Shahram Majidi, Dimitri Sigounas, Christopher R Leon Guerrero
Background: Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are both viable treatment options for carotid artery stenosis. We sought to compare perioperative outcomes after CEA and CAS for the management of carotid stenosis using a "real-world" sample. Methods: We conducted a retrospective observational study using the National Surgical Quality Improvement Program database to compare 30-day (periprocedural) outcomes in patients with carotid stenosis undergoing CEA versus CAS from 2005 to 2012...
June 2018: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29922347/the-cardiovascular-benefits-associated-with-the-use-of-sodium-glucose-cotransporter-2-inhibitors-real-world-data
#15
REVIEW
Gallwitz Baptist
Type 2 diabetes (T2D) is associated with numerous comorbidities that significantly reduce quality of life, increase mortality and complicate treatment decisions. In a recent cardiovascular outcomes trial, Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME), the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin was shown to reduce cardiovascular (CV) mortality and heart failure in high-risk patients with T2D with a previous CV event or with established CV disease (CVD)...
April 2018: European Endocrinology
https://www.readbyqxmd.com/read/29922182/brain-natriuretic-peptide-and-its-biochemical-analytical-and-clinical-issues-in-heart-failure-a-narrative-review
#16
REVIEW
Shihui Fu, Ping Ping, Qiwei Zhu, Ping Ye, Leiming Luo
Heart failure (HF) is a primary cause of morbidity and mortality worldwide. As the most widely studied and commonly applied natriuretic peptide (NP), B-type natriuretic peptide (BNP) has the effects of diuresis, natriuresis, vasodilation, anti-hypertrophy, and anti-fibrosis and it inhibits the renin-angiotensin-aldosterone and sympathetic nervous systems to maintain cardiorenal homeostasis and counteract the effects of HF. Both BNP and N-terminal pro B-type natriuretic peptide (NT-proBNP) are applied as diagnostic, managing, and prognostic tools for HF...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29922067/elevated-levels-of-vitamin-b12-in-chronic-stable-heart-failure-a-marker-for-subclinical-liver-damage-and-impaired-prognosis
#17
Onur Argan, Dilek Ural, Kurtuluş Karauzum, Serdar Bozyel, Mujdat Aktas, Irem Yilmaz Karauzum, Güliz Kozdag, Aysen Agacdiken Agir
Background: Elevated vitamin B12 is a sign for liver damage, but its significance in chronic stable heart failure (HF) is less known. The present study investigated the clinical correlates and prognostic significance of vitamin B12 levels in stable systolic HF. Methods: A total of 129 consecutive patients with HF and 50 control subjects were enrolled. Data regarding demographics, clinical signs, therapeutic and conventional echocardiographic measurements were recorded for all patients...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29922041/burden-of-heart-failure-on-caregivers-in-china-results-from-a-cross-sectional-survey
#18
James Ds Jackson, Sarah E Cotton, Sara Bruce Wirta, Catia C Proenca, Milun Zhang, Raquel Lahoz, Frederico J Calado
Purpose: Family and friends play a pivotal role in caring for patients with heart failure (HF); however, evidence of the impact of caregiving is limited. The objectives of this study were to describe the burden of caregiving on informal caregivers of patients with chronic HF in China. Materials and methods: A cross-sectional survey of cardiologists, their patients with HF, and those patients' caregivers was conducted. Patient record forms were completed by 150 cardiologists for 10 consecutive patients...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29922040/burden-of-heart-failure-on-patients-from-china-results-from-a-cross-sectional-survey
#19
James Ds Jackson, Sarah E Cotton, Sara Bruce Wirta, Catia C Proenca, Milun Zhang, Raquel Lahoz, Frederico J Calado
Purpose: Little evidence exists on the burden that chronic heart failure (HF) poses specifically to patients in China. The objective of this study, therefore, was to describe the burden of HF on patients in China. Materials and methods: A cross-sectional survey of cardiologists and their patients with HF was conducted. Patient record forms were completed by 150 cardiologists for 10 consecutive patients. Patients for whom a patient record form was completed were invited to complete a patient questionnaire...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29922027/large-nonapical-right-ventricular-diverticulum-in-a-patient-with-atrioventricular-septal-defect
#20
Michael Weidenbach, Bardo Wannenmacher, Christian Paech, Robert Wagner
Congenital diveticula and aneurysm of the heart are rare and most often located at the apex of the left ventricle. They pose a significant risk for cardiac failure and arrhythmias. In contrast, nonapical diverticula of the right ventricle (RV) have a much more benign course. We present a child with Trisomy 21, atrioventricular septal defect, and large nonapical diverticulum of the RV that was neither addressed during surgery nor needed any medical treatment during 1-year follow-up.
May 2018: Annals of Pediatric Cardiology
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