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https://www.readbyqxmd.com/read/29245138/cardiac-sarcoidosis-presenting-as-arrhythmogenic-right-ventricular-cardiomyopathy-dysplasia-with-ventricular-aneurysms-a-case-report
#1
Marija Petrovic, L Maximilian Buja, Biswajit Kar, Jure Colnaric, Sarita Damaraju, Bihong Zhao, Bindu Akkanti, Milan Radovanovic, Rajko Radovancevic, Pranav Loyalka, Igor D Gregoric
A 70-year old Caucasian man with recurrent ventricular tachycardia and progressive biventricular failure attributed to arrhythmogenic right ventricular cardiomyopathy/dysplasia was evaluated for heart transplantation. Cardiac ventriculography revealed an abnormal left ventricle with five saccular aneurysms. Heart transplantation was performed. Pathology of the explanted heart showed multifocal sarcoid granulomas. Replacement fibrosis was widespread in both ventricles and associated with saccular aneurysms. No genetic basis was identified...
November 10, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29244648/diagnostic-value-of-the-physical-examination-in-patients-with-dyspnea
#2
REVIEW
Richard A Shellenberger, Bathmapriya Balakrishnan, Sindhu Avula, Ariadne Ebel, Sufiya Shaik
We reviewed the evidence for the diagnostic accuracy of the physical examination in diagnosing pneumonia, pleural effusion, chronic obstructive pulmonary disease, and congestive heart failure in patients with dyspnea and found that the physical examination has reliable diagnostic accuracy for these common conditions.
December 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29244531/effects-of-natural-peptides-from-food-proteins-on-angiotensin-converting-enzyme-activity-and-hypertension
#3
Melanie Martin, Andreas Deussen
Cardiovascular diseases are the leading cause of death. The underlying pathophysiology is largely contributed by an overactivation of the renin-angiotensin-aldosterone-system (RAAS). Herein, angiotensin II (AngII) is a key mediator not only in blood pressure control and vascular tone regulation, but also involved in inflammation, endothelial dysfunction, atherosclerosis, hypertension and congestive heart failure. Since more than three decades suppression of AngII generation by inhibition of the angiotensin-converting enzyme (ACE) or blockade of the AngII-receptor has shown clinical benefit by reducing hypertension, atherosclerosis and other inflammation-associated cardiovascular diseases...
December 15, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29244074/the-heart-regulates-the-endocrine-response-to-heart-failure-cardiac-contribution-to-circulating-neprilysin
#4
Mattia Arrigo, Nicolas Vodovar, Hélène Nougué, Malha Sadoune, Chris J Pemberton, Pamela Ballan, Pierre-Olivier Ludes, Nicolas Gendron, Alain Carpentier, Bernard Cholley, Philippe Bizouarn, Alain Cohen-Solal, Jagmeet P Singh, Jackie Szymonifka, Christian Latremouille, Jane-Lise Samuel, Jean-Marie Launay, Julien Pottecher, A Mark Richards, Quynh A Truong, David M Smadja, Alexandre Mebazaa
Aims: Heart failure (HF) is accompanied by major neuroendocrine changes including the activation of the natriuretic peptide (NP) pathway. Using the unique model of patients undergoing implantation of the CARMAT total artificial heart and investigating regional differences in soluble neprilysin (sNEP) in patients with reduced or preserved systolic function, we studied the regulation of the NP pathway in HF. Methods and results: Venous blood samples from two patients undergoing replacement of the failing ventricles with a total artificial heart were collected before implantation and weekly thereafter until post-operative week 6...
December 13, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29244037/a-psychometric-evaluation-of-the-chinese-version-of-the-m-d-anderson-symptom-inventory-heart-failure-in-chinese-cancer-patients-with-concurrent-heart-failure
#5
Sek Ying Chair, Qun Wang, Mingming Yu, Winnie Kwok Wei So, Chang Tian, Janet Wing Hung Sit, Eliza Mi Ling Wong, Carmen Wing Han Chan, Anecita Fadol
PURPOSE: The purpose of the study was to translate the M.D. Anderson Symptom Inventory-Heart Failure (MDASI-HF), a specific instrument to assess symptoms in cancer patients with concurrent heart failure (HF), into Mandarin Chinese and to examine its psychometric properties in Chinese cancer patients. DESIGN: A translation and psychometric evaluation design was used. METHODS: The translation of the MDASI-HF into Mandarin Chinese followed Brislin's model with the four steps: translation, monolingual assessment, backward translation, and comparison...
November 2017: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29243525/galectin-3-and-outcomes-after-anterior-wall-myocardial-infarction-treated-by-primary-percutaneous-coronary-intervention
#6
Giuseppe Di Tano, Giorgio Caretta, Renata De Maria, Luca Bettari, Marina Parolini, Sophie Testa, Salvatore Pirelli
AIM: Galectin-3 (Gal-3), a biomarker of inflammation, tissue repair and fibrogenesis, is associated to left ventricular remodeling after ST-elevated myocardial infarction (STEMI), but its relation with long-term outcomes is unclear. METHODS: In 103 consecutive patients with a first anterior STEMI treated by primary angioplasty, we assayed Gal-3 and NT-proBNP. RESULTS: Age was 65 (56-76) years, 28% were women. During 18 ± 13 months, 20 patients (19...
December 15, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29243505/cardiopulmonary-exercise-testing-and-risk-stratification-in-heart-failure-with-reduced-midrange-or-preserved-ejection-fraction-when-nomenclature-may-not-match-with-pathophysiology
#7
Marco Guazzi
No abstract text is available yet for this article.
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29243396/bariatric-surgery-induced-cardiac-and-lipidomic-changes-in-obesity-related-heart-failure-with-preserved-ejection-fraction
#8
Deana Mikhalkova, Sujata R Holman, Hui Jiang, Mohammed Saghir, Eric Novak, Andrew R Coggan, Robert O'Connor, Adil Bashir, Ali Jamal, Daniel S Ory, Jean E Schaffer, J Christopher Eagon, Linda R Peterson
OBJECTIVE: To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF). METHODS: A primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary cohort and were confirmed in a validation cohort (N = 22)...
December 15, 2017: Obesity
https://www.readbyqxmd.com/read/29243322/transient-myocardial-thickening-in-cats-associated-with-heart-failure
#9
J Novo Matos, N Pereira, T Glaus, L Wilkie, K Borgeat, J Loureiro, J Silva, V Law, A Kranjc, D J Connolly, V Luis Fuentes
BACKGROUND: Cats with hypertrophic cardiomyopathy (HCM) and congestive heart failure (CHF) can have resolution of both left ventricular hypertrophy and CHF. OBJECTIVES: To describe the clinical characteristics of cats with transient myocardial thickening (TMT) and CHF compared with a control population of cats without resolution of HCM. ANIMALS: A total of 21 cats with TMT, 21 cats with HCM. METHODS: Retrospective study...
December 15, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29243229/mirabegron-potential-off-target-effects-and-uses-beyond-the-bladder
#10
REVIEW
Nodi Dehvari, Edilson Dantas da Silva Junior, Tore Bengtsson, Dana S Hutchinson
The ®3 -adrenoceptor was initially an attractive target by several pharmaceutical companies due to its high expression in rodent adipose tissue, where its activation resulted in decreased adiposity and improved metabolic outputs (such as glucose handling) in animal models of obesity and type 2 diabetes. However, several drugs acting at the β3 -adrenoceptor failed in clinical trials. This was thought to be due to their lack of efficacy at the human receptor. Recently mirabegron, a ®3 -adrenoceptor agonist with human efficacy, was approved in North America, Europe, Japan and Australia for the treatment of overactive bladder syndrome...
December 15, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29243066/serum-glucocorticoid-regulated-kinase-1-contributes-to-mechanical-stretch-induced-inflammatory-responses-in-cardiac-fibroblasts
#11
Wenqiang Gan, Tiegang Li, Jingyuan Ren, Chenghe Li, Ziliang Liu, Min Yang
Excessive mechanical stretch induces production of proinflammatory mediators in cardiac fibroblasts, which could act as inflammatory supporter cells in heart failure. Accumulation evidence and our previous studies suggest that serum-glucocorticoid-regulated kinase 1 (SGK1) contributes to cardiac remodeling and fibrosis, development of heart failure. However, the role and mechanism of SGK1 in mechanical stretch-induced inflammation of cardiac fibroblasts remain unclear. Here, cardiac fibroblasts isolated from wild-type (WT) and SGK1 knockout (SGK1-/-) mice were stimulated by 18% cyclic stretch, under static condition as the control...
December 14, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29243046/-stem-cell-based-cardiac-regeneration-after-myocardial-infarction
#12
REVIEW
M Reinsch, F Weinberger
Myocardial infarction leads to an irreversible loss of vital myocardial cells. The transplantation of new cardiomyocytes into the heart was first described over 20 years ago and represents a straightforward approach to remuscularize a damaged heart. Due to the lack of human cells a clinical application seemed ambitious; however, dramatic progress in stem cell biology over the last two decades has paved the way towards a clinical application. This is especially important as the prognosis for patients with terminal heart failure is still poor...
December 14, 2017: Herz
https://www.readbyqxmd.com/read/29243014/prognostic-value-of-lvedp-in-acute-myocardial-infarction-a-systematic-review-and-meta-analysis
#13
Stephen C Brienesse, Allan J Davies, Arshad Khan, Andrew J Boyle
Left ventricular end-diastolic pressure (LVEDP) is an easily obtained, physiologically integrative measure of total LV function. LVEDP may be a useful prognostic measure in patients with acute myocardial infarction and utilised to guide medical therapy and assess risk for post myocardial infarction heart failure. To assess the utility of LVEDP as a prognostic measure in patients presenting with acute myocardial infarction. We performed an unrestricted search of electronic databases (1946 to March 2017) using a predefined search strategy...
December 14, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29242982/-iron-a-miralcle-cure-for-chronic-cardiac-insufficiency
#14
REVIEW
Katrin Singler
Anemia and chronic heart failure are frequent comorbidities in geriatric patients. In approximately one third of older adults the cause of the anemia is an iron, vitamin B12 and/or folate deficiency and in another third a chronic inflammatory process is present. In the case of iron deficiency a differentiation must be made between the absolute and functional forms. Although in functional iron deficiency ferritin, as a parameter of iron metabolism, is within the normal range or can even be higher, an iron-deficient erythropoiesis is present...
December 14, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29242353/cardiac-specific-bdh1-overexpression-ameliorates-oxidative-stress-and-cardiac-remodeling-in-pressure-overload-induced-heart-failure
#15
Motoki Uchihashi, Atsushi Hoshino, Yoshifumi Okawa, Makoto Ariyoshi, Satoshi Kaimoto, Shuhei Tateishi, Kazunori Ono, Ryoetsu Yamanaka, Daichi Hato, Yohei Fushimura, Sakiko Honda, Kuniyoshi Fukai, Yusuke Higuchi, Takehiro Ogata, Eri Iwai-Kanai, Satoaki Matoba
BACKGROUND: Energy starvation and the shift of energy substrate from fatty acids to glucose is the hallmark of metabolic remodeling during heart failure progression. However, ketone body metabolism in the failing heart has not been fully investigated. METHODS AND RESULTS: Microarray data analysis and mitochondrial isobaric tags for relative and absolute quantification proteomics revealed that the expression of D-β-hydroxybutyrate dehydrogenase I (Bdh1), an enzyme that catalyzes the NAD+/NADH coupled interconversion of acetoacetate and β-hydroxybutyrate, was increased 2...
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29242352/predicting-risk-in-patients-hospitalized-for-acute-decompensated-heart-failure-and-preserved-ejection-fraction-the-atherosclerosis-risk-in-communities-study-heart-failure-community-surveillance
#16
Tonje Thorvaldsen, Brian L Claggett, Amil Shah, Susan Cheng, Sunil K Agarwal, Lisa M Wruck, Patricia P Chang, Wayne D Rosamond, Eldrin F Lewis, Akshay S Desai, Lars H Lund, Scott D Solomon
BACKGROUND: Risk-prediction models specifically for hospitalized heart failure with preserved ejection fraction are lacking. METHODS AND RESULTS: We analyzed data from the ARIC (Atherosclerosis Risk in Communities) Study Heart Failure Community Surveillance to create and validate a risk score predicting mortality in patients ≥55 years of age admitted with acute decompensated heart failure with preserved ejection fraction (ejection fraction ≥50%). A modified version of the risk-prediction model for acute heart failure developed from patients in the EFFECT (Enhanced Feedback for Effective Cardiac Treatment) study was used as a composite predictor of 28-day and 1-year mortalities and evaluated together with other potential predictors in a stepwise logistic regression...
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29242350/nt-probnp-guided-therapy-in-acute-decompensated-heart-failure-the-prima-ii-randomized-controlled-trial
#17
Susan Stienen, Khibar Salah, Arno H Moons, Adrianus L Bakx, Petra van Pol, Mikael Kortz, João Pedro Ferreira, Irene Marques, Jutta M Schroeder-Tanka, Jan T Keijer, Antoni Bayés-Genis, Jan G P Tijssen, Yigal M Pinto, Wouter E Kok
Background -The concept of natriuretic peptide guidance has been extensively studied in chronic heart failure (HF) patients, with only limited success. The effect of NT-proBNP-guided therapy in acute decompensated HF (ADHF) patients using a relative NT-proBNP target has not been investigated. The aim of this study was to assess whether NT-proBNP-guided therapy of ADHF patients using a relative NT-proBNP target would lead to improved outcome compared with conventional therapy. Methods -We conducted a prospective randomized, controlled trial to study the impact of in-hospital guidance for ADHF treatment by a predefined NT-proBNP target (>30% reduction from admission to discharge) versus conventional treatment...
December 14, 2017: Circulation
https://www.readbyqxmd.com/read/29242240/persistence-of-infarct-zone-t2-hyperintensity-at-6-months-after-acute-st-segment-elevation-myocardial-infarction-incidence-pathophysiology-and-prognostic-implications
#18
Jaclyn Carberry, David Carrick, Caroline Haig, Nadeem Ahmed, Ify Mordi, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Stuart Hood, Stuart Watkins, Mitchell Lindsay, Andrew Davie, Ahmed Mahrous, Ian Ford, Naveed Sattar, Paul Welsh, Aleksandra Radjenovic, Keith G Oldroyd, Colin Berry
BACKGROUND: The incidence and clinical significance of persistent T2 hyperintensity after acute ST-segment-elevation myocardial infarction (STEMI) is uncertain. METHODS AND RESULTS: Patients who sustained an acute STEMI were enrolled in a cohort study (BHF MR-MI: NCT02072850). Two hundred eighty-three STEMI patients (mean age, 59±12 years; 75% male) had cardiac magnetic resonance with T2 mapping performed at 2 days and 6 months post-STEMI. Persisting T2 hyperintensity was defined as infarct T2 >2 SDs from remote T2 at 6 months...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29242134/non-contrast-estimation-of-diffuse-myocardial-fibrosis-with-dual-energy-ct-a-phantom-study
#19
Vidhya Kumar, Kevin E McElhanon, James K Min, Xin He, Zhaobin Xu, Eric X Beck, Orlando P Simonetti, Noah Weisleder, Subha V Raman
BACKGROUND: Estimation of diffuse myocardial fibrosis, substrate for adverse events such as heart failure and arrhythmias in patients with various cardiac disorders, is presently done by histopathology or cardiac magnetic resonance. We sought to develop a non-contrast method to estimate the amount of diffuse myocardial fibrosis leveraging dual energy computed tomography (DECT) in phantoms and a suitable small animal model. METHODS AND RESULTS: Phantoms consisted of homogenized bovine myocardium with varying amounts of Type 1 collagen...
December 5, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29242100/takotsubo-is-not-a-cardiomyopathy
#20
Francesco Pelliccia, Gianfranco Sinagra, Perry Elliott, Guido Parodi, Cristina Basso, Paolo G Camici
Unraveling the mechanisms underlying Takotsubo (TTS) leads to question the current inclusion of the condition within the spectrum of cardiomyopathies. Indeed, the clinical presentation and pathophysiology of TTS clearly differ from cardiomyopathies, i.e. diseases of heart muscle unexplained by abnormal loading conditions or coronary artery disease, which cannot recover spontaneously and may cause sudden death often in minimally symptomatic individuals or result in a gradual deterioration in ventricular function and end-stage heart failure...
December 9, 2017: International Journal of Cardiology
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