Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Diego E Razura, Yael Bensoussan, Christopher G Lui, Michael M Johns, Lindsay Reder, Alexander Gelbard, Karla O'Dell
OBJECTIVE: Idiopathic subglottic stenosis (iSGS) is a rare condition involving the subglottic larynx and upper trachea, commonly affecting Caucasian females between 30 and 50 years of age. Despite its homogeneous presentation, clinical management for iSGS is yet to be standardized, leading to variability in outcomes between predominant interventions. In recognition of the heterogenicity in iSGS treatment and the need to improve patient outcomes, this study aimed to survey laryngologists to understand the factors influencing clinical decision-making and the incorporation of new treatment modalities for iSGS...
September 5, 2023: Laryngoscope
#22
JOURNAL ARTICLE
Laura M Mafla, Rafael Ospino, Raymond J So, Alexandra J Berges, Samuel L Collins, Yee Chan-Li, Ibrahim Abd-Elazem, Kevin Motz, Alexander T Hillel
OBJECTIVE: To narrow knowledge gaps in the pathophysiology of idiopathic subglottic stenosis (iSGS) through comparison of a murine subglottic stenosis model with iSGS. STUDY DESIGN: In vivo animal study. SETTING: Academic institution. METHODS: Murine samples/measurements were obtained from mice that underwent chemomechanical injury with a wire brush and bleomycin. Human samples/measurements were obtained from iSGS patients...
August 25, 2023: Otolaryngology—Head and Neck Surgery
#23
JOURNAL ARTICLE
Alexandra J Berges, Rafael Ospino, Laura Mafla, Samuel Collins, Yee Chan-Li, Baishakhi Ghosh, Venkataramana Sidhaye, Ioan Lina, Alexander T Hillel
OBJECTIVES: To aim of the study was to characterize the molecular profile and functional phenotype of idiopathic subglottic stenosis (iSGS)-scar epithelium. METHODS: Human tracheal biopsies from iSGS scar (n = 6) and matched non-scar (n = 6) regions were analyzed using single-cell RNA sequencing (scRNA-seq). Separate specimens were used for epithelial cell expansion in vitro to assess average growth rate and functional capabilities using transepithelial-electrical resistance (TEER), fluorescein isothiocyanate-dextran flux permeability assay, ciliary coverage, and cilia beating frequency (CBF)...
August 10, 2023: Laryngoscope
#24
JOURNAL ARTICLE
Richard J Lu, Baraa Hijaz, Matthew R Naunheim, Lily Stevenson, Ramon A Franco
BACKGROUND: Idiopathic subglottic stenosis (iSGS) is a recurrent, chronic disease defined by fibro-inflammatory narrowing of the subglottic airway. A key challenge in treatment is monitoring disease progression, which may be debilitating and unpredictable in timing. RESEARCH QUESTION: Can the SGS-6 Questionnaire be validated as a novel QOL instrument to proactively monitor breathing, disease progression and disease severity in patients with idiopathic subglottic stenosis? STUDY DESIGN AND METHODS: Panel data from 51 patients with iSGS were collected from January 2012 through June 2022, representing 1,684 patient encounters including routine office visits and treatment encounters...
August 4, 2023: Chest
#25
JOURNAL ARTICLE
Eshita Singh, Haley Hullfish, Aaron Fils, Ruixuan Ma, David Rosow
OBJECTIVES: Sequelae of laryngotracheal stenosis (LTS) can be devastating, often necessitating tracheostomy. This study aims to describe the characteristics and outcomes of patients with LTS and identify risk factors for long-term tracheostomy dependence stratified by etiology. METHODS: A retrospective chart review was performed on 215 patients diagnosed with LTS from 09/01/2011 to 12/31/2020. Patients were grouped based on the cause of LTS. Patient factors were compared to evaluate risk factors for long-term tracheostomy dependence...
July 27, 2023: Laryngoscope
#26
JOURNAL ARTICLE
Edward Ryan R Talatala, Evan Clark, Wenda Ye, Ruth J Davis, Alexander T Hillel, Samuel L Collins, Marisol Ramirez-Solano, Quanhu Sheng, Alexander Gelbard
OBJECTIVES: Idiopathic subglottic stenosis (iSGS) is an unexplained progressive fibrosis of the upper airway. iSGS almost exclusively affects women; as a result, female hormones (estrogen and progesterone) have been proposed to participate in the pathogenesis of iSGS. Our aim was to localize cell-specific gene expression of estrogen receptors (ESR1 and ESR2) and progesterone receptor (PGR) using an established iSGS single-cell RNA sequencing (scRNAseq) cell atlas. STUDY DESIGN: Ex vivo molecular study of airway scar and healthy mucosa from iSGS patients...
June 29, 2023: Laryngoscope
#27
JOURNAL ARTICLE
Anders Erlandsson, Mimmi Werner, Anna Holm, Alexandra Schindele, Katarina Olofsson
BACKGROUND: Subglottic stenosis (SGS) is a narrowing of the airway just below the vocal folds. The cause of SGS and the optimal care for these patients, have remained elusive. Endoscopic surgery of SGS using either balloon or CO2 laser is associated with recurrence. AIMS AND OBJECTIVES: Our aim is to compare surgery free intervals (SFI) between these two methods applied in two different timeframes. The knowledge gained from this project can support decision-making regarding surgical method choice...
June 21, 2023: Acta Oto-laryngologica
#28
Alexander Gelbard, Meghan H Shilts, Britton Strickland, Kevin Motz, Hsiu-Wen Tsai, Helen Boone, Wonder P Drake, Celestine Wanjalla, Paula Marincola Smith, Hunter Brown, Marisol Ramierez, James B Atkinson, Jason Powell, John Simpson, Seesandra V Rajagopala, Simon Mallal, Quanhu Sheng, Alexander T Hillel, Suman R Das
Background Idiopathic subglottic stenosis (iSGS) is a rare fibrotic disease of the proximal airway affecting adult Caucasian women nearly exclusively. Life-threatening ventilatory obstruction occurs secondary to pernicious subglottic mucosal scar. Disease rarity and wide geographic patient distribution has previously limited substantive mechanistic investigation into iSGS pathogenesis. Result By harnessing pathogenic mucosa from an international iSGS patient cohort and single-cell RNA sequencing, we unbiasedly characterize the cell subsets in the proximal airway scar and detail their molecular phenotypes...
May 19, 2023: Research Square
#29
JOURNAL ARTICLE
Jake A Langlie, Luke J Pasick, David E Rosow
OBJECTIVES: Repeat endoscopic dilation (ED) in the operating room for subglottic stenosis (SGS) remains an economic burden to patients. The cost-effectiveness (CE) of adjuvant serial intralesional steroid injections (SILSI) to prolong the surgery-free interval (SFI) in SGS patients requiring ED has yet to be studied. METHODS: Details of the cost of SILSI and ED were received from our tertiary academic center. SFI, cost of intervention, and the effect of SILSI on prolonging SFI were collected from a systematic review by Luke et al...
June 6, 2023: Laryngoscope
#30
JOURNAL ARTICLE
Alexandra D'Oto, Hayley Baker, Ted Mau, Lesley F Childs, Kathleen M Tibbetts
OBJECTIVE: To compare characteristics of patients ≥65 years presenting with idiopathic subglottic stenosis (iSGS) to patients diagnosed at <65 years. We hypothesize that the groups have similar comorbidities and disease courses. DATA SOURCES: Medical records of patients treated for iSGS at a tertiary care institution from January 2005-September 2022. REVIEW METHODS: Patient demographics, time from symptom onset to diagnosis, medical history and comorbidities, and treatment modalities/intervals were recorded and analyzed...
May 11, 2023: Laryngoscope
#31
JOURNAL ARTICLE
Kayvon Sharif, William S Tierney, Ruth J Davis, Elizabeth Wohler, Nara Sobreira, Alexander T Hillel, Samuel Collins, Marisol Ramirez-Solano, Quanhu Sheng, Alexander Gelbard
OBJECTIVES: Recent translational scientific efforts in subglottic stenosis (SGS) support a disease model where epithelial alterations facilitate microbiome displacement, dysregulated immune activation, and localized fibrosis. Yet despite recent advances, the genetic basis of SGS remains poorly understood. We sought to identify candidate risk genes associated with an SGS phenotype, investigate their biological function, and identify the cell types enriched for their expression. METHODS: The Online Mendelian Inheritance in Man (OMIM) database was queried for single gene variants associated with an SGS phenotype...
April 27, 2023: Laryngoscope
#32
JOURNAL ARTICLE
William S Tierney, Li-Ching Huang, Sheau-Chiann Chen, Lynn D Berry, Catherine Anderson, Milan R Amin, Michael S Benninger, Joel H Blumin, Jonathan M Bock, Paul C Bryson, Paul F Castellanos, Matthew S Clary, Seth M Cohen, Brianna K Crawley, Seth H Dailey, James J Daniero, Alessandro de Alarcon, Donald T Donovan, Eric S Edell, Dale C Ekbom, Daniel S Fink, Ramon A Franco, Catherine Gaelyn Garrett, Elizabeth A Guardiani, Alexander T Hillel, Henry T Hoffman, Norman D Hogikyan, Rebecca J Howell, Michael M Johns, Jan L Kasperbauer, Sid M Khosla, Cheryl Kinnard, Robbi A Kupfer, Alexander J Langerman, Robert J Lentz, Robert R Lorenz, David G Lott, Samir S Makani, Fabien Maldonado, Laura Matrka, Andrew J McWhorter, Albert L Merati, Matthew Mori, James L Netterville, Karla O'Dell, Julina Ongkasuwan, Gregory N Postma, Lindsay S Reder, Sarah L Rohde, Brent E Richardson, Otis B Rickman, Clark A Rosen, Matthew Rohlfing, Michael J Rutter, Guri S Sandhu, Joshua S Schindler, Glenn Todd Schneider, Rupali N Shah, Andrew G Sikora, Robert J Sinard, Marshall E Smith, Libby J Smith, Ahmed M S Soliman, Sigríður Sveinsdóttir, David Veivers, Sunil P Verma, Paul M Weinberger, Philip A Weissbrod, Christopher T Wootten, Yu Shyr, David O Francis, Alexander Gelbard
The North American Airway Collaborative (NoAAC) previously published a 3-year multi-institutional prospective cohort study showing variation in treatment effectiveness between 3 primary surgical techniques for idiopathic subglottic stenosis (iSGS). In this report, we update these findings to include 5 years of data evaluating treatment effectiveness. Patients in the NoAAC cohort were re-enrolled for 2 additional years and followed using the prespecified published protocol. Consistent with prior data, prospective observation of 487 iSGS patients for 5 years showed treatment effectiveness differed by modality...
June 2023: Otolaryngology—Head and Neck Surgery
#33
JOURNAL ARTICLE
Stephen Schoeff, Matthew R Hoffman, Yanchen Zhang, Qiuyu Yang, Seth H Dailey
OBJECTIVE: To describe treatment pathways and long-term outcomes in 64 patients with idiopathic subglottic stenosis (iSGS), including the impact of serial intralesional steroid injection (SILSI) on degree of stenosis, need for subsequent operation, and patient-reported outcome measures. METHODS: Retrospective review of 64 female patients with iSGS undergoing varied management approaches, 57 of whom underwent SILSI as at least part of their care. Treatment pathways included SILSI only, endoscopic intervention followed by SILSI only, endoscopic interventions only, endoscopic intervention followed by SILSI followed by need for repeat endoscopic intervention, open surgery, and tracheotomy...
November 2023: Annals of Otology, Rhinology, and Laryngology
#34
JOURNAL ARTICLE
Matthew L Rohlfing, Alexander T Hillel, Elizabeth Wohler, Nara Sobreira, Elizabeth J Phillips, Simon A Mallal, Alexander Gelbard
OBJECTIVE: Despite recent scientific inquiry, idiopathic subglottic stenosis (iSGS) remains an enigmatic disease. The consistent demographics of the affected population suggest genetic factors may contribute to disease susceptibility. Given the inflammation observed in the affected proximal airway mucosa, we interrogated disease association with human leukocyte antigen (HLA) polymorphisms. Polymorphisms in the HLA locus have previously been shown to influence individuals' susceptibility to distinct inflammatory diseases...
February 2, 2023: Laryngoscope
#35
JOURNAL ARTICLE
Karla O'Dell, Valerie Huang, Joseph Acevedo, Lindsay Reder, Michael Johns, Li Ding
OBJECTIVES: To evaluate the long-term benefit of serial in-office steroid injections (SISI) in the treatment of subglottic and proximal tracheal stenosis (SG/PTS). Evaluate cost of SISI compared to endoscopic dilation (ED). STUDY DESIGN: Retrospective study and cost analysis. METHODS: All patients with SGS/PTS with at least two consecutive in-office steroid injections between 2013 and 2021 were evaluated. Patients with less than 2 years of follow-up data after the initial SISI series were excluded...
January 24, 2023: Laryngoscope
#36
JOURNAL ARTICLE
Rafael Ospino, Alexandra Berges, Laura Mafla, Samuel Collins, Yee Chan Li, Ioan Lina, Alexander Gelbard, Alexander T Hillel, Kevin Motz
OBJECTIVES: Idiopathic subglottic stenosis (iSGS) is characterized by progressive fibrosis and subglottic luminal narrowing. Currently, immune characterization has focused on T-cells; however, macrophages remain largely unexplored. The goals of this study are to characterize the transcriptome of iSGS macrophages and the fibrogenic nature of identifed biomarkers. STUDY DESIGN: Bioinformatics and in vitro. METHODS: Human tracheal biopsies from iSGS scar (n = 4), and matched non-scar (n = 4) regions were analyzed using single-cell RNA-seq (scRNA-seq)...
December 16, 2022: Laryngoscope
#37
JOURNAL ARTICLE
Adrien Ferney, Thibault Ferney, Ludovic Giraud, Amandine Briault, Marie-Pierre Aboussouan, Paul F Castellanos, Ihab Atallah
PURPOSE: Various surgical techniques could be used to treat subglottic stenosis (SGS). The aim of this study is to present our experience in endoscopic management of SGS and show the impact of symptoms' evaluation, clinical examination and spirometry in the therapeutic decision. METHODS: Endoscopic treatment was performed in patients referred for SGS and consisted of CO2 scar lysis associated with balloon dilation and concomitant steroids' injection for patients with grade II or higher on the mMRC (modified Medical Research Council) dyspnea scale associated with a DI (Dyspnea Index) score higher than 10/40 and objective stenosis equal or higher than grade II...
April 2023: European Archives of Oto-rhino-laryngology
#38
JOURNAL ARTICLE
Garrett Ni, Arnav Shah, Nicole Molin, Scott Schartel, Ahmed M S Soliman
BACKGROUND/OBJECTIVE: Traditional jet ventilation requires the use of a catheter that is inserted either through an endotracheal tube or laryngoscope. Specially designed laryngoscopes with a built-in luer lock adapter to which the high-pressure tubing may be attached exist but are not always available. We present our experience with an adapter which allows connection of the high-pressure tubing to the suction side port of suitable laryngoscopes that is easily assembled using readily available materials in the operating room...
October 8, 2022: Annals of Otology, Rhinology, and Laryngology
#39
REVIEW
Bradley A Richards, Katherine Z Xie, Andrew Jay Bowen, Aisha Aden, Joshua Wiedermann, Amy L Rutt, Robert Vassallo, Eric S Edell, Semirra L Bayan, Jan L Kasperbauer, Dale C Ekbom
OBJECTIVES: Endoscopic laser wedge excision (LWE) is an effective treatment option for idiopathic subglottic stenosis (iSGS); however, data regarding complications following LWE are limited. The aim of the following analysis was to provide a review of frequency and type of complications that occur with LWE in patients with iSGS. STUDY DESIGN: Retrospective review. METHODS: Patients with iSGS undergoing LWE between January 2002 and September 2021 were performed...
2022: American Journal of Otolaryngology
#40
Wolfgang Tebbe, Helmut Wittkowski, Johannes Tebbe, Georg Hülskamp
An 8-year-old girl presented with treatment-refractory cough and inspiratory stridor. Bronchoscopies showed progressive scarring leading to narrowing of the proximal trachea (Myer-Cotton Grade 2) and epithelial metaplasia of the tracheal and bronchial mucosa. After excluding other causes of congenital and acquired tracheal stenosis, an idiopathic subglottic tracheal stenosis (iSGS) was diagnosed. Because of the patient's young age, a judicious therapeutic approach seemed appropriate. Therapy with azithromycin, followed by roxithromycin, was started...
2022: Frontiers in Pediatrics
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
