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Xiang-Yan Chen, Mark Fisher
Within the intracranial vasculature, atherosclerosis occurs in two distinctive patterns: (1) in Western populations who have severe extracranial and systemic atherosclerosis, the severity of intracranial involvement is consistently less than that within extracranial arteries; and (2) in Asians, Africans, and Hispanics, who often have isolated intracranial arterial disease that is found to be more often accompanied by brain infarction than comparable extracranial atherosclerotic disease. Compared to coronary and extracranial carotid atherosclerosis, intracranial atherosclerosis has distinct pathological characteristics compared to that of extracranial arteries...
2016: Frontiers of Neurology and Neuroscience
Juan F Arenillas, Elena López-Cancio, Ka Sing Wong
Increasing our knowledge about intracranial atherosclerosis (ICAS) natural history and prognostic factors is essential to improve its preventive therapy and thus reduce the dramatic clinical consequences caused by this entity. ICAS is characterized by a chronic and progressive course until it becomes symptomatic, mostly through complication of an unstable intracranial atherosclerotic plaque. Population-based studies in healthy subjects have shown that the prevalence of asymptomatic ICAS is higher in Asian than in Caucasian populations...
2016: Frontiers of Neurology and Neuroscience
Peng Hu, Qi Yang, Dan-Dan Wang, Shao-Chen Guan, Hong-Qi Zhang
INTRODUCTION: The aneurysm wall has been reported to play a critical role in the formation, development, and even rupture of an aneurysm. We used high-resolution magnetic resonance imaging (HRMRI) to investigate the aneurysm wall in an effort to identify evidence of inflammation invasion and define its relationship with aneurysm behavior. METHODS: Patients with intracranial aneurysms who were prospectively evaluated using HRMRI between July 2013 and June 2014 were enrolled in this study...
October 2016: Neuroradiology
Yu-Yuan Xu, Ming-Li Li, Shan Gao, Bo Hou, Zhao-Yong Sun, Hai-Long Zhou, Feng Feng, Wei-Hai Xu
OBJECTIVE: In this study, we sought to examine the prevalence and clinical relevance of deep tiny flow voids (DTFV) in patients with steno-occlusive middle cerebral artery (MCA) disease on high-resolution MRI (HRMRI). METHODS: We retrospectively reviewed the HRMRI and clinical data of 477 patients with MCA steno-occlusive disease. The presence and distribution of DTFV, defined as 3 or more flow voids along the affected MCA on at least 2 consecutive T2-weighted image slices on HRMRI, were observed...
May 24, 2016: Neurology
Tanya N Turan, Todd LeMatty, Renee Martin, Marc I Chimowitz, Zoran Rumboldt, M Vittoria Spampinato, Seth Stalcup, Robert J Adams, Truman Brown
BACKGROUND: Intracranial atherosclerosis is a leading cause of stroke, but little is known about the composition of the intracranial atherosclerotic lesion and how intracranial plaque morphology is related to the risk of stroke. High-resolution magnetic resonance imaging (HR MRI) has been used in patients with extracranial carotid atherosclerosis as an in vivo tool to identify, with high-interrater agreement, histologically defined plaque components (i.e., intraplaque hemorrhage, fibrous cap, and lipid core), which have been shown to be predictors of recurrent stroke...
December 2015: Brain and Behavior
Jeong-Min Kim, Keun-Hwa Jung, Chul-Ho Sohn, Jangsup Moon, Jung-Hwan Shin, Jaeseok Park, Seung-Hoon Lee, Moon Hee Han, Jae-Kyu Roh
BACKGROUND: Intracranial atherosclerosis is associated with frequent stroke recurrence. High resolution vessel wall magnetic resonance imaging (HRMRI) can provide atheroma information related to its vulnerability. AIMS: We performed HRMRI in stroke patients with intracranial atherosclerosis to determine whether plaque characteristics from vessel wall imaging can predict future stroke recurrence. METHODS: Between July 2011 and June 2013, acute stroke patients with symptomatic intracranial atherosclerosis were prospectively enrolled and 3-tesla HRMRI was performed on the relevant artery...
February 2016: International Journal of Stroke: Official Journal of the International Stroke Society
Luca Petrone, Stefania Nannoni, Alessandra Del Bene, Vanessa Palumbo, Domenico Inzitari
BACKGROUND: In 1989, Louis Caplan first used the term branch atheromatous disease (BAD) to describe an occlusion or stenosis at the origin of a deep penetrating artery of the brain, associated with a microatheroma or a junctional plaque, and leading to an internal capsule or pontine small infarct. BAD remained an understudied concept for decades. In recent years, the increasing diffusion of high-resolution magnetic resonance imaging (HRMRI) techniques brought new attention to the BAD debate...
2016: Cerebrovascular Diseases
Zhongzhao Teng, Wenjia Peng, Qian Zhan, Xuefeng Zhang, Qi Liu, Shiyue Chen, Xia Tian, Luguang Chen, Adam J Brown, Martin J Graves, Jonathan H Gillard, Jianping Lu
OBJECTIVE: Although certain morphological features depicted by high resolution, multi-contrast magnetic resonance imaging (hrMRI) have been shown to be different between culprit and non-culprit middle cerebral artery (MCA) atherosclerotic lesions, the incremental value of hrMRI to define culprit lesions over stenosis has not been assessed. METHODS: Patients suspected with MCA stenosis underwent hrMRI. Lumen and outer wall were segmented to calculate stenosis, plaque burden (PB), volume (PV), length (PL) and minimum luminal area (MLA)...
July 2016: European Radiology
Dong Hyun Chun, Sung Tae Kim, Young Gyun Jeong, Hae Woong Jeong
The equipment and techniques associated with magnetic resonance imaging (MRI) have rapidly evolved. The development of 3.0 Tesla MRI has enabled high-resolution imaging of the intracranial vessel wall. High-resolution MRI (HRMRI) can yield excellent visualization of both the arterial wall and lumen, thus facilitating the detection of the primary and secondary features of intracranial arterial dissection. In the present report, we describe the manner in which HRMRI affected our endovascular treatment planning strategy in 2 cases with unruptured intracranial vertebral artery dissection aneurysm...
August 2015: Journal of Korean Neurosurgical Society
Jin Hee Yu, Hyo Sung Kwak, Gyung Ho Chung, Seung Bae Hwang, Mi Sung Park, Seong Hoon Park
BACKGROUND AND PURPOSE: High-resolution magnetic resonance imaging (HRMRI) is ideal for serial examination of diseased arterial walls because it is noninvasive and has superior capability of discriminating tissue characteristics. The aim of this study is to evaluate the prevalence and clinical relevance of intraplaque hemorrhage (IPH) in patients with basilar artery (BA) atherosclerosis using HRMRI. METHODS: We analyzed HRMRI and clinical data from 74 patients (45 symptomatic and 29 asymptomatic), all of whom had >50% BA stenosis...
October 2015: Stroke; a Journal of Cerebral Circulation
Haiqing Yang, Yifei Zhu, Zuojun Geng, Caiying Li, Lixia Zhou, Q I Liu
The present study evaluated the value of black-blood high-resolution magnetic resonance imaging (HRMRI) for the visualization of intracranial atherosclerosis (ICAS) plaques. A total of 110 patients with cerebral artery or vertebrobasilar stenosis, vessel occlusion or a significantly weakened signal in black-blood magnetic resonance angiography (MRA; three-dimensional time-of-flight) were examined. Black-blood MRA was used to observe whether plaques were present in the abnormal vascular walls. Among the 110 patients with cerebral infarction, 16 cases presented with no significant abnormality of the lumen and walls, while plaques were observed in 94 cases...
July 2015: Experimental and Therapeutic Medicine
Sung-Hwan Lim, Hojin Choi, Hee-Tae Kim, Juhan Kim, Sung Hyuk Heo, Dae-il Chang, Ji Young Lee, Young-Jun Lee, Ji Young Kim, Hyun Young Kim, Young Seo Kim
BACKGROUND: The association between progressive motor deficits (PMD) in acute pontine infarction and basilar stenosis is unclear. High resolution MRI (HRMRI) is an emerging tool for basilar artery evaluation and might provide more accurate information. We aimed to analyze the association between basilar plaque assessed by HRMRI and PMD after acute pontine infarction. METHODS: We identified consecutive patients with unilateral pontine infarction within 24 h of stroke onset...
May 2015: Atherosclerosis
Tanya N Turan, Zoran Rumboldt, Ann-Charlotte Granholm, Laura Columbo, Cynthia T Welsh, Maria F Lopes-Virella, M Vittoria Spampinato, Truman R Brown
BACKGROUND: High-resolution MRI (HRMRI) is a promising tool for studying intracranial atherosclerotic disease (ICAD) in-vivo, but its use to understand the pathophysiology of ICAD has been limited by a lack of correlation between MRI signal characteristics and pathology in intracranial arteries. DESCRIPTION OF CASE: A patient with symptomatic left cavernous carotid stenosis underwent 3T HRMRI and died 4 days later. In-vivo HRMRI and postmortem histopathology images were compared...
December 2014: Atherosclerosis
Min Yuan, Zhi-qiang Liu, Zhi-qiang Wang, Bin Li, Li-jun Xu, Xin-lan Xiao
High resolution magnetic resonance imaging (HRMRI) has been developed as an emerging tool for evaluating intracranial arterial disease. We aimed to analyze the progression of diseased arterial walls in moyamoya disease (MMD) and further elucidate differences compared to intracranial atherosclerotic stenosis using HRMRI. The population of this HRMRI study consisted of 21 patients with MMD and 44 patients with atherosclerotic middle cerebral artery (MCA) stenosis. The cross-sectional images of the MCA wall on HRMRI were compared between the two groups based on outer diameter, wall thickness, luminal stenotic morphology, signal intensity, collateral vascular structures adjacent to stenotic position...
January 1, 2015: Neuroscience Letters
Xiang-Yan Chen, Tao Tang, Ka-Sing Wong
Intracranial atherosclerotic stenosis (ICAS) of a major intracranial artery, especially middle cerebral artery (MCA), is reported to be one leading cause of ischemic stroke throughout the world. Compared with other stroke subtypes, ICAS is associated with a higher risk of recurrent stroke despite aggressive medical therapy. Increased understanding of the pathophysiology of ICAS has highlighted several possible targets for therapeutic interventions. Both luminal stenosis and plaque components of ICAS have been found to be associated with ischemic stroke based a post-mortem study...
August 2014: Annals of Translational Medicine
Ai Lyn Tan, Eiji Fukuba, Nicola Ann Halliday, Steven F Tanner, Paul Emery, Dennis McGonagle
OBJECTIVE: Dactylitis is a hallmark of psoriatic arthritis (PsA) where flexor tenosynovitis is common. This study explored the microanatomical basis of dactylitis using high-resolution MRI (hrMRI) to visualise the small entheses around the digits. METHODS: Twelve patients with psoriatic dactylitis (4 fingers, 8 toes), and 10 healthy volunteers (6 fingers, 4 toes) had hrMRI of the digits using a 'microscopy' coil and contrast enhancement. All structures were evaluated including the tendons and ligaments, related enthesis organs, pulleys, volar/plantar plates and tendon sheaths...
January 2015: Annals of the Rheumatic Diseases
P H Gao, L Yang, G Wang, L Guo, X Liu, B Zhao
PURPOSE: Isolated middle cerebral artery dissection (MCAD) is a rare but important clinical entity. The purpose of this study is to demonstrate the clinical and magnetic resonance imaging (MRI) features of symptomatic unruptured isolated MCAD. METHODS: We retrospectively analyzed clinical characteristics and MRI features of eight consecutive ischemic stroke patients diagnosed with unruptured isolated MCAD over a 1-year period. RESULTS: All the patients had symptoms of cerebral infarction, whereas one patient was presented as transient ischemic attack...
March 2016: Clinical Neuroradiology
Tae Hyung Kim, Jin Woo Choi, Hong Gee Roh, Won-Jin Moon, Sung Gyu Moon, Young Il Chun, Hahn Young Kim
OBJECTIVE: Prior to detecting intracranial arterial stenosis, atherosclerotic wall change or plaque with positive remodeling can be evaluated with high-resolution MRI (HRMRI). We prospectively evaluate atherosclerotic arterial wall change in patients without intracranial stenosis using HRMRI at 3.0T and correlate the atherosclerotic change, cerebrovascular risk factors, and white matter hyperintensity (WMH). METHODS: Patients were prospectively recruited for one year and underwent brain MRI, TOF-MRA and HRMRI using axial 3D T1 FSE of the intracranial arteries...
November 2014: Clinical Neurology and Neurosurgery
Jonas J-H Park, Anmin Shen, Sebastian Keil, Nils Kraemer, Martin Westhofen
The objective of the present study was to evaluate the cochlear aqueduct (CA) in Meniere's disease (MD) and to disclose radiological differences of CA between MD and non-MD patients by means of high-resolution computed tomography (HRCT) and high-resolution magnetic resonance imaging (HRMRI). Radiological data of 86 ears of MD patients which were separated into 52 ears of diseased side group (MD-D group) and 34 ears of contralateral non-affected side group of unilateral MD (MD-ND group), 27 ears of patients with sensorineural hearing loss (SNHL group) and 56 ears of patients with somatoform dizziness and normal hearing (control group) were analyzed retrospectively...
December 2014: European Archives of Oto-rhino-laryngology
Tianli Gao, Wei Yu, Chunjie Liu
High-resolution magnetic resonance imaging (HRMRI) has a unique ability to provide an evaluation of the intracranial artery wall. This study aimed to investigate the possible mechanisms of ischemic stroke in patients with intracranial atherosclerosis using HRMRI. HRMRI was performed on 55 patients (38 male and 17 female) with acute cerebral infarction to investigate the lumen-intruding plaque at the stenotic portion of the middle cerebral artery (MCA) and basilar artery (BA) and to attempt to identify the mechanisms of stroke...
May 2014: Experimental and Therapeutic Medicine
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