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https://www.readbyqxmd.com/read/28535376/dephosphorylation-of-the-ndc80-tail-stabilizes-kinetochore-microtubule-attachments-via-the-ska-complex
#1
Dhanya K Cheerambathur, Bram Prevo, Neil Hattersley, Lindsay Lewellyn, Kevin D Corbett, Karen Oegema, Arshad Desai
During cell division, genome inheritance is orchestrated by microtubule attachments formed at kinetochores of mitotic chromosomes. The primary microtubule coupler at the kinetochore, the Ndc80 complex, is regulated by Aurora kinase phosphorylation of its N-terminal tail. Dephosphorylation is proposed to stabilize kinetochore-microtubule attachments by strengthening electrostatic interactions of the tail with the microtubule lattice. Here, we show that removal of the Ndc80 tail, which compromises in vitro microtubule binding, has no effect on kinetochore-microtubule attachments in the Caenorhabditis elegans embryo...
May 22, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28535204/colocalization-of-receptors-for-shiga-toxins-with-lipid-rafts-in-primary-human-renal-glomerular-endothelial-cells-and-influence-of-d-pdmp-on-synthesis-and-distribution-of-glycosphingolipid-receptors
#2
Nadine Legros, Gottfried Pohlentz, Jana Runde, Stefanie Dusny, Hans-Ulrich Humpf, Helge Karch, Johannes Müthing
Damage of human renal glomerular endothelial cells (HRGECs) of the kidney represents the linchpin in the pathogenesis of the hemolytic uremic syndrome (HUS) caused by Shiga toxins (Stxs) of enterohemorrhagic Escherichia coli (EHEC). We performed a comprehensive structural analysis of the Stx receptor glycosphingolipids (GSLs) globotriaosylceramide (Gb3Cer, Galα4alβ4Glcβ1Cer) and globotetraosylceramide (Gb4Cer, GalNAcβ3Galα4Galβ4Glcβ1Cer) and their distribution in lipid raft analogue detergent-resistant membranes (DRMs) and nonDRMs prepared from primary HRGECs...
May 23, 2017: Glycobiology
https://www.readbyqxmd.com/read/28534362/the-expression-of-claudin-4-in-gastric-cancer-tissue-a-single-center-experience
#3
Demetrios Moris, Dimitrios Schizas, Adamantios Michalinos, Prodromos Kanavidis, Nikolaos Dimitrokallis, Andreas Alexandrou, Evangelos Misiakos, Theodoros Liakakos
PURPOSE: Gastric cancer (GC) is still one of the most common malignancies with the majority of the tumors diagnosed at advanced stage. The need for identification of prognostic and early detection biomarkers is thus compulsory. Claudins are biomarkers that are currently evaluated in the literature in the frame of epithelial-mesenchymal transition. The purpose of this investigation was to study the expression of claudin-4 in the various histological subtypes of GC and to evaluate its prognostic value...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28534359/e-cadherin-in-gastric-carcinomas-relations-with-histological-parameters-and-its-prognostic-value
#4
Dimitrios Schizas, Demetrios Moris, Adamantios Michalinos, Prodromos Kanavidis, Dimitrios Oikonomou, Alexandros Papalampros, Anastasios Machairas, Theodoros Liakakos
PURPOSE: Gastric cancer (GC) is still one of the most common malignancies with the majority of the tumors being diagnosed at advanced stage. The need for identification of prognostic and early detection biomarkers is thus compulsory. E-cadherin is one of the emerging biomarkers that is currently evaluated in the literature in the frame of epithelial-mesenchymal transition (EMT). Our aim was to study the expression of E-cadherin in the various histological subtypes of GC and to evaluate its prognostic value...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28533815/efficient-itaconic-acid-production-from-glycerol-with-ustilago-vetiveriae-tz1
#5
Thiemo Zambanini, Hamed Hosseinpour Tehrani, Elena Geiser, Dorothee Merker, Sarah Schleese, Judith Krabbe, Joerg M Buescher, Guido Meurer, Nick Wierckx, Lars M Blank
BACKGROUND: The family of Ustilaginaceae is known for their capability to naturally produce industrially valuable chemicals from different carbon sources. Recently, several Ustilaginaceae were reported to produce organic acids from glycerol, which is the main side stream in biodiesel production. RESULTS: In this study, we present Ustilago vetiveriae as new production organism for itaconate synthesis from glycerol. In a screening of 126 Ustilaginaceae, this organism reached one of the highest titers for itaconate combined with a high-glycerol uptake rate...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28533760/the-role-of-prosocialness-and-trust-in-the-consumption-of-water-as-a-limited-resource
#6
Esther Cuadrado, Carmen Tabernero, Rocío García, Bárbara Luque, Jan Seibert
This research analyzes the role of prosocialness and trust in the use of water as a limited resource under situations of competition or cooperation. For this purpose, 107 participants played the role of farmers and made decisions about irrigating their fields in the web-based multiplayer game Irrigania. Before the simulation exercise, participants' prosocialness and trust levels were evaluated and they were randomly assigned to an experimental condition (competition or cooperation). Repeated measures analysis, using the 10 fields and the experimental conditions as factors, showed that, in the cooperation condition, farmers and their villages used a less selfish strategy to cultivate their fields, which produced greater benefits...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28533753/age-related-assessment-of-sugar-and-protein-intake-of-ceratitis-capitata-in-ad-libitum-conditions-and-modeling-its-relation-to-reproduction
#7
Nikos A Kouloussis, Petros T Damos, Charalambos S Ioannou, Constantinos Tsitsoulas, Nikos T Papadopoulos, David Nestel, Dimitris S Koveos
In the inquiry on the age related dietary assessment of an organism, knowledge of the distributional patterns of food intake throughout the entire life span is very important, however, age related nutritional studies often lack robust feeding quantification methods due to their limitations in obtaining short-term food-intake measurements. In this study, we developed and standardized a capillary method allowing precise life-time measurements of food consumption by individual adult medflies, Ceratitis capitata (Diptera: Tephritidae), under laboratory conditions...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28533672/effect-of-a-counseling-supported-treatment-with-the-mediterranean-diet-and-physical-activity-on-the-severity-of-the-non-alcoholic-fatty-liver-disease
#8
Chiara Gelli, Mirko Tarocchi, Ludovico Abenavoli, Laura Di Renzo, Andrea Galli, Antonino De Lorenzo
AIM: To determine the clinical effectiveness of nutritional counseling on reduction of non-alcoholic fatty liver disease (NAFLD) severity, weight loss, metabolic and anthropometric indexes and liver enzymes. METHODS: Forty-six adults with NAFLD received a 6-mo clinical and a dietary intervention (based on Mediterranean diet) carried out respectively by a gastroenterologist and a nutritionist with counseling license. The counseling process consisted of monthly meeting (about 45 min each)...
May 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28533629/the-effects-of-a-multisensory-dynamic-balance-training-on-the-thickness-of-lower-limb-muscles-in-ultrasonography-in-children-with-spastic-diplegic-cerebral-palsy
#9
Seung-Min Nam, Won-Hyo Kim, Chang-Kyo Yun
[Purpose] This study aimed to investigate the effects of multisensory dynamic balance training on muscles thickness such as rectus femoris, anterior tibialis, medial gastrocnemius, lateral gastrocnemius in children with spastic diplegic cerebral palsy by using ultrasonography. [Subjects and Methods] Fifteen children diagnosed with spastic diplegic cerebral palsy were divided randomly into the balance training group and control group. The experimental group only received a multisensory dynamic balance training, while the control group performed general physiotherapy focused balance and muscle strengthening exercise based Neurodevelopmental treatment...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28533611/the-effect-of-horse-riding-simulator-exercise-on-the-gait-muscle-strength-and-muscle-activation-in-elderly-people-with-knee-osteoarthritis
#10
Seung-Kyu Kim, Seong-Gil Kim, Gak HwangBo
[Purpose] The aim of this study was to examine the effects of horse-riding simulator exercise on gait ability and muscle strength, muscle activation in elderly with knee osteoarthritis. [Subjects and Methods] Thirty elderly patients with knee osteoarthritis were recruited, a horse-riding simulator group consisted of fifteen subjects and they performed exercise three times a week for eight weeks. And each exercise was performed, horse riding simulator exercise for 15 minutes and knee strengthening exercise for 15 minutes...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28533608/changes-of-gait-parameters-following-constrained-weight-shift-training-in-patients-with-stroke
#11
Seok Hyun Nam, Sung Min Son, Kyoung Kim
[Purpose] This study aimed to investigate the effects of training involving compelled weight shift on the paretic lower limb on gait parameters and plantar pressure distribution in patients with stroke. [Subjects and Methods] Forty-five stroke patients participated in the study and were randomly divided into: group with a 5-mm lift on the non-paretic side for constrained weight shift training (5: constrained weight shift training) (n=15); group with a 10-mm lift on the non-paretic side for constrained weight shift training (10: constrained weight shift training) (n=15); or the control group (n=15)...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28533566/cohort-changes-in-the-social-distribution-of-tolerant-sexual-attitudes
#12
Fred C Pampel
Though many studies have described societal-wide changes in tolerance for sexual behaviors outside marriage, few have examined how the social distribution of tolerant attitudes has changed. A diffusion-of-innovations approach predicts nonlinear change in the distribution: high SES groups adopt the attitudes first, which produces a positive relationship, but diffusion to other SES groups subsequently weakens the association with SES. I test this argument using the General Social Survey from 1973 to 2014 to compare the SES determinants of attitudes toward premarital sex, extramarital sex, same-gender sex, and teenage sex across 86 cohorts born from around 1900 to 1985...
December 7, 2016: Social Forces; a Scientific Medium of Social Study and Interpretation
https://www.readbyqxmd.com/read/28533359/selective-regulation-of-notch-ligands-during-angiogenesis-is-mediated-by-vimentin
#13
Daniel Antfolk, Marika Sjöqvist, Fang Cheng, Kimmo Isoniemi, Camille L Duran, Adolfo Rivero-Muller, Christian Antila, Rasmus Niemi, Sebastian Landor, Carlijn V C Bouten, Kayla J Bayless, John E Eriksson, Cecilia M Sahlgren
Notch signaling is a key regulator of angiogenesis, in which sprouting is regulated by an equilibrium between inhibitory Dll4-Notch signaling and promoting Jagged-Notch signaling. Whereas Fringe proteins modify Notch receptors and strengthen their activation by Dll4 ligands, other mechanisms balancing Jagged and Dll4 signaling are yet to be described. The intermediate filament protein vimentin, which has been previously shown to affect vascular integrity and regenerative signaling, is here shown to regulate ligand-specific Notch signaling...
May 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28532944/effect-of-prostaglandin-analogue-use-on-the-development-of-cystoid-macular-edema-after-phacoemulsification-using-strobe-statement-methodology
#14
REVIEW
David J Hernstadt, Rahat Husain
Cataract surgery is a common procedure, and cystoid macular edema (CME) is a sight-threatening complication. Prostaglandin analogues are the first-line therapy for glaucoma, but their effect on the risk for CME after phacoemulsification is unknown. A systematic search of Medline and PubMed was performed to determine the effect of the use of prostaglandin analogues (PGA) on the development of CME after cataract surgery. A total of 412 articles were identified. Thirteen articles met inclusion criteria and were analyzed using Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28532898/toughening-of-fibrous-scaffolds-by-mobile-mineral-deposits
#15
Justin Lipner, John J Boyle, Younan Xia, Victor Birman, Guy M Genin, Stavros Thomopoulos
Partially mineralized fibrous tissue situated between tendon and bone is believed to be tougher than either tendon or bone, possibly serving as a compliant, energy absorptive, protective barrier between the two. This tissue does not reform following surgical repair (e.g., rotator cuff tendon-to-bone re-attachment) and might be a factor in the poor outcomes following such surgeries. Towards our long-term goal of tissue engineered solutions to functional tendon-to-bone re-attachment, we tested the hypotheses that partially mineralized fibrous matrices can derive toughness from mobility of mineral along their fibers, and that in such cases toughness is maximized at levels of mineralization sufficiently low to allow substantial mobility...
May 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28532734/a-family-centered-intervention-for-the-transition-to-living-with-multiple-myeloma-as-a-chronic-illness-a-pilot-study
#16
Susan R Mazanec, Sarah Miano, Linda Baer, Erica L Campagnaro, Abdus Sattar, Barbara J Daly
Patients with multiple myeloma and their family caregivers must master self-management tasks related not only to the disease and treatment, but also associated with transitioning to living with chronic illness. The aim of this study was to assess the feasibility, acceptability, safety, and fidelity of an intervention that had a psychoeducational approach and included a low-impact, home-based walking activity. A secondary aim was to obtain preliminary data of the effect of the intervention, as compared to an attention control group, on anxiety, activation for self-management, fatigue, depression and health-related quality of life (HRQOL)...
June 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28532732/nurses-health-promoting-lifestyle-behaviors-in-a-community-hospital
#17
Emma Kurnat-Thoma, Majeda El-Banna, Monica Oakcrum, Jill Tyroler
PURPOSE: To examine nurses' health-promoting lifestyle behaviors, describe their self-reported engagement in employee wellness program benefit options, and explore relationships between nurse demographic factors, health characteristics and lifestyle behaviors. BACKGROUND: Nurses adopting unhealthy lifestyle behaviors are at significantly higher risk for developing a number of chronic diseases and are at increased susceptibility to exhaustion, job dissatisfaction and turnover...
June 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28532612/why-evidence-based-medicine-failed-in-patient-care-and-medicine-based-evidence-will-succeed
#18
Ralph I Horwitz, Burton H Singer
Evidence-based medicine (EBM) has succeeded in strengthening the evidence base for population medicine. Where EBM has failed is in answering the practicing doctor's question of what a likely outcome would be when a given treatment is administered to a particular patient with her own distinctive biological and biographical (life experience) profile. We propose Medicine-based evidence (MBE), based on the profiles of individual patients, as the evidence base for individualized or personalized medicine. MBE will build an archive of patient profiles using data from all study types and data sources, and will include both clinical and socio-behavioral information...
April 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28532551/strengthening-renal-registries-and-esrd-research-in-africa
#19
REVIEW
M Razeen Davids, Fergus J Caskey, Taryn Young, Gillian K Balbir Singh
In Africa, the combination of noncommunicable diseases, infectious diseases, exposure to environmental toxins, and acute kidney injury related to trauma and childbirth are driving an epidemic of chronic kidney disease and end-stage renal disease (ESRD). Good registry data can inform the planning of renal services and can be used to argue for better resource allocation, audit the delivery and quality of care, and monitor the impact of interventions. Few African countries have established renal registries and most have failed owing to resource constraints...
May 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28532536/-role-of-sox4-on-ddp-resistance-in-non-small-cell-lung-cancer-cell-of-a549
#20
Wei Li, Xu Liu, Guoqian Zhang, Linlin Zhang
BACKGROUND: Lung cancer is one of the most serious disease and the incidence of non-small cell lung cancer (NSCLC) is the highest in lung cancer. The main reason for the failure of chemotherapy is the tolerance to cisplatin. Transcriptional regulator SOX4 plays an important role in the occurrence and development of many tumors, and regulates Wnt signaling pathway by regulating the expression of β-catenin. We aimed to investigate the role of SOX4 on cisplatin-resistance in NSCLC cell A549 cell...
May 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
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