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https://www.readbyqxmd.com/read/28102773/the-optimal-duration-of-anticoagulant-therapy-after-unprovoked-venous-thromboembolism-still-a-challenging-issue
#1
Giovanna Elmi, Giuseppe Di Pasquale, Raffaele Pesavento
As about 50 % of patients with unprovoked venous thromboembolism (VTE) will develop new episodes after discontinuing therapy, indefinite treatment is suggested in patients with low or moderate bleeding risk. Baseline and post-baseline factors can help clinicians to identify patients at high risk of recurrence, who require extended treatment. Residual vein obstruction and D-dimer assay have been shown to be suitable methods for assessing the risk of VTE recurrences after a first unprovoked VTE. In treatment for VTE the use of direct oral anticoagulants (DOAC) is growing instead of the standard adjusted dose of vitamin K antagonists...
January 19, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28102338/strengthening-of-ceramic-based-artificial-nacre-via-synergistic-interactions-of-1d-vanadium-pentoxide-and-2d-graphene-oxide-building-blocks
#2
Andrea Knöller, Christian P Lampa, Felix von Cube, Tingying Helen Zeng, David C Bell, Mildred S Dresselhaus, Zaklina Burghard, Joachim Bill
Nature has evolved hierarchical structures of hybrid materials with excellent mechanical properties. Inspired by nacre's architecture, a ternary nanostructured composite has been developed, wherein stacked lamellas of 1D vanadium pentoxide nanofibres, intercalated with water molecules, are complemented by 2D graphene oxide (GO) nanosheets. The components self-assemble at low temperature into hierarchically arranged, highly flexible ceramic-based papers. The papers' mechanical properties are found to be strongly influenced by the amount of the integrated GO phase...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102277/us-energy-agency-strengthens-protections-for-scientists
#3
Erin Ross
No abstract text is available yet for this article.
January 11, 2017: Nature
https://www.readbyqxmd.com/read/28101813/a-multi-us-city-assessment-of-awareness-and-uptake-of-pre-exposure-prophylaxis-prep-for-hiv-prevention-among-black-men-and-transgender-women-who-have-sex-with-men
#4
Lisa A Eaton, Derrick D Matthews, Daniel D Driffin, Leigh Bukowski, Patrick A Wilson, Ron D Stall
The HIV epidemic among Black men and transgender women who have sex with men (BMTW) demands an urgent public health response. HIV point prevalence among this population ranges from 25 to 43%-a rate far exceeding any other group. Pre-exposure prophylaxis (PrEP) for HIV prevention is a very promising prevention tool; however, its full potential to slow the epidemic has yet to be realized. For the current study, random time-location sampling at Black Gay Pride Events was used to collect data from N = 1274 BMTW, from five US cities, reporting HIV-negative/unknown status...
January 18, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28101758/applying-collaborative-learning-and-quality-improvement-to-public-health-lessons-from-the-collaborative-improvement-and-innovation-network-coiin-to-reduce-infant-mortality
#5
Reem M Ghandour, Katherine Flaherty, Ashley Hirai, Vanessa Lee, Deborah Klein Walker, Michael C Lu
OBJECTIVES: Infant mortality remains a significant public health problem in the U.S. The Collaborative Improvement & Innovation Network (CoIIN) model is an innovative approach, using the science of quality improvement and collaborative learning, which was applied across 13 Southern states in Public Health Regions IV and VI to reduce infant mortality and improve birth outcomes. We provide an in-depth discussion of the history, development, implementation, and adaptation of the model based on the experience of the original CoIIN organizers and participants...
January 18, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28101717/trace-metals-accumulation-in-soil-irrigated-with-polluted-water-and-assessment-of-human-health-risk-from-vegetable-consumption-in-bangladesh
#6
REVIEW
Md Atikul Islam, Davor Romić, Md Ali Akber, Marija Romić
Trace metals accumulation in soil irrigated with polluted water and human health risk from vegetable consumption was assessed based on the data available in the literature on metals pollution of water, soil, sediment and vegetables from the cites of Bangladesh. The quantitative data on metal concentrations, their contamination levels and their pollution sources have not been systematically gathered and studied so far. The data on metal concentrations, sources, contamination levels, sample collection and analytical tools used were collected, compared and discussed...
January 18, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28101563/world-health-organisation-global-disability-action-plan-2014-2021-challenges-and-perspectives-for-physical-medicine-and-rehabilitation-in-pakistan
#7
Fary Khan, Bhasker Amatya, Tahir M Sayed, Aamir W Butt, Khalid Jamil, Waseem Iqbal, Alaeldin Elmalik, Farooq A Rathore, Geoff Abbott
OBJECTIVE: To provide an update on disability and outline potential barriers and facilitators for implementation of the World Health Organization Global Disability Action Plan (GDAP) in Pakistan. METHODS: A 6-day workshop at the Armed Forces Institute of Rehabilitation Medicine, Islamabad facilitated by rehabilitation staff from Royal Melbourne Hospital, Australia. Local healthcare professionals (n = 33) from medical rehabilitation facilities identified challenges in service provision, education and attitudes/approaches to people with disabilities, using consensus agreement for objectives listed in the GDAP...
January 19, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28101233/lipid-raft-localization-of-epidermal-growth-factor-receptor-alters-matrix-metalloproteinase-1-expression-in-siha-cells-via-the-mapk-erk-signaling-pathway
#8
Zongfeng Zhang, Lina Wang, Juan Du, Yuanbo Li, Huilun Yang, Chenxi Li, Hui Li, Haiyang Hu
Matrix metalloproteinase-1 (MMP-1) has been identified as an important participant in tumor invasion, metastasis and angiogenesis. The purpose of the present study was to investigate the effects of epidermal growth factor receptor (EGFR) localization to lipid rafts on signaling pathways involved in the regulation of MMP-1 expression in SiHa cells, a cervical cancer cell line. EGFR activation by EGF specifically induced MMP-1 expression at both the messenger RNA and protein levels. Additionally, it was observed that EGFR localized to lipid rafts, and that the redistribution of EGFR induced by lipid raft disruption strengthened EGF-induced MMP-1 expression...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28101132/what-are-good-outcomes-in-public-mental-health-settings-a-qualitative-exploration-of-clients-and-therapists-experiences
#9
Christian Moltu, Jon Stefansen, Jan Christian Nøtnes, Åse Skjølberg, Marius Veseth
BACKGROUND: The mental health field sees a surge of interest in Routine Outcome Monitoring, mandated by a wish to help better those not-on-track to recovery. What constitutes positive outcomes for these patients is not fully understood. AIMS: To contribute knowledge into what constitutes meaningful outcome concepts in the experiences of patients with long and complex mental health suffering and treatment, and the clinicians who work to help them. METHODS: A qualitative in-depth study of 50 participants' experiences...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28101116/journey-to-motherhood-in-the-first-year-after-child-birth
#10
Nahid Javadifar, Fereshteh Majlesi, Alireza Nikbakht, Saharnaz Nedjat, Ali Montazeri
Objective: Child bearing is a period of psychological challenges that must be viewed in a social context. This study reports the maternal transition from the perspective of Iranian first-time mothers in the first year after childbirth. Materials and methods: Qualitative method was chosen for explanation of mothers' individual experiences of motherhood.26 first-time mothers (aged 18-35 years old with various socio-economic status) who had delivered between 0-1 year prior to the interviews participated in the study...
September 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/28100911/variants-on-chromosome-4q21-near-pkd2-and-siblings-are-associated-with-dental-caries
#11
Scott Eckert, Eleanor Feingold, Margaret Cooper, Michael M Vanyukov, Brion S Maher, Rebecca L Slayton, Marcia C Willing, Steven E Reis, Daniel W McNeil, Richard J Crout, Robert J Weyant, Steven M Levy, Alexandre R Vieira, Mary L Marazita, John R Shaffer
A recent genome-wide association study (GWAS) for dental caries nominated the chromosomal region 4q21 near ABCG2, PKD2 and the SIBLING (small integrin-binding ligand N-linked glycoprotein) gene family. In this investigation, we followed up and fine-mapped this region using a tag-SNP (single-nucleotide polymorphism) approach in 13 age- and race-stratified samples from 6 independent studies (N=4089). Participants were assessed for dental caries via intraoral examination and 49 tag-SNPs were genotyped capturing much of the variation in the 4q21 locus...
January 19, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28100737/selectivity-in-postencoding-connectivity-with-high-level-visual-cortex-is-associated-with-reward-motivated-memory
#12
Vishnu P Murty, Alexa Tompary, R Alison Adcock, Lila Davachi
: Reward motivation has been demonstrated to enhance declarative memory by facilitating systems-level consolidation. Although high-reward information is often intermixed with lower reward information during an experience, memory for high value information is prioritized. How is this selectivity achieved? One possibility is that postencoding consolidation processes bias memory strengthening to those representations associated with higher reward. To test this hypothesis, we investigated the influence of differential reward motivation on the selectivity of postencoding markers of systems-level memory consolidation...
January 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28100695/mapping-the-affinity-landscape-of-thrombin-binding-aptamers-on-2-f-ana-dna-chimeric-g-quadruplex-microarrays
#13
Jory Lietard, Hala Abou Assi, Irene Gómez-Pinto, Carlos González, Mark M Somoza, Masad J Damha
In situ fabricated nucleic acids microarrays are versatile and very high-throughput platforms for aptamer optimization and discovery, but the chemical space that can be probed against a given target has largely been confined to DNA, while RNA and non-natural nucleic acid microarrays are still an essentially uncharted territory. 2'-Fluoroarabinonucleic acid (2'F-ANA) is a prime candidate for such use in microarrays. Indeed, 2'F-ANA chemistry is readily amenable to photolithographic microarray synthesis and its potential in high affinity aptamers has been recently discovered...
January 18, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28100609/sterol-binding-by-the-tombusviral-replication-proteins-is-essential-for-replication-in-yeast-and-plants
#14
Kai Xu, Peter D Nagy
: Membranous structures derived from various organelles are important for replication of plus-stranded RNA viruses. Although the important roles of co-opted host proteins in RNA virus replication have been appreciated for a decade, the equally important functions of cellular lipids in virus replication are gaining full attention only recently. Previous works with Tomato bushy stunt tombusvirus (TBSV) in model host yeast have revealed essential roles for phosphatidylethanolamine and sterols in viral replication...
January 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28100390/-how-to-write-high-quality-epidemiological-research-paper-%C3%A2-strengthening-the-reporting-of-observational-studies-in-epidemiology-nutritional-epidemiology-strobe-nut
#15
C Y Ding, Y Cao, C Yang, F Sun, S Y Zhan
Concerns have been raised about the reporting quality in nutritional epidemiology. Therefore, strengthening the reporting of observational studies in epidemiology-nutritional epidemiology (STROBE-nut) has been proposed by extending the STROBE statement to include additional recommendations on issues related to nutritional epidemiology and dietary assessment, aiming to provide more specific guidelines on how to report observational research in the field. This paper presents a brief introduction to STROBE-nut and also an explanation of the key points in the additional items, with an example illustrating the application of the checklist...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28100383/-hiv-antibody-detection-results-in-patients-seeking-medical-care-in-peking-union-medical-college-hospital-2003-2014
#16
X J Song, Z F Qiu, W Cao, J Xie, Z J Zhang, S X Xu, T S Li
Objective: To better understand the infection status of HIV in the patients seeking medical care in Peking Union Medical College Hospital. Methods: The HIV detection data of the patients in the hospital from 2003-2014 were collected for a statistical analysis with software SPSS 19.0. Results: A total of 715 421 patients were screened, and 1 012 (0.14%) patients were HIV positive, and HIV infection were confirmed in 776 (0.11%) patients by Western Blot testing. The detection rate of HIV infection increased from 0...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28100382/-epidemiological-pattern-of-abnormal-urinary-fluoride-rates-in-population-with-occupational-fluoride-exposure-in-shanghai
#17
M H Gu, J Su, C H Liu, Y Q Zhu, H Shen, Y H Huang, L Zhong, M H Zhang, Y H Li
Objective: To investigate the epidemiological features of abnormal urinary fluoride rates in population with occupational exposure, and its relationships with age, work years and gender in Shanghai. Methods: A questionnaire survey was conducted respectively in 4 999 exposed workers and 283 non-exposed people during 2012-2015. Their urine samples were collected in plastic bottles and the fluoride ion selective electrode method was used for urinary fluoride level analysis. Logistic regression model was used to estimate associations between the abnormal rates and demographic/socioeconomic status of the study subjects...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28100381/-trend-of-mortality-of-congenital-malformation-in-children-aged-5-years-in-beijing-2006-2015
#18
J Wang, D Y Li, W X Zhang, Y C Li, J Wang
Objective: To investigate the change in mortality of congenital malformation in children aged <5 years in Beijing from 2006 to 2015. Methods: Using the death surveillance data in children aged <5 years in Beijing from 2006 to 2015, which was collected from the real-time surveillance network, we calculated the area and age distributions of the mortality of congenital malformation in children aged <5 years in Beijing. Meanwhile, the variations of age, time and space in the causes of deaths were discussed...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28100373/-epidemiological-characteristics-of-children-aged-1-4-years-without-timely-birth-dose-of-hepatitis-b-vaccine-vaccination-in-china-2014
#19
F Z Wang, G M Zhang, L P Shen, J H Liu, H Zheng, F Wang, N Miao, X J Sun, X F Liang, F Q Cui
Objective: To evaluate the epidemiological characteristics of the children aged 1-4 years without timely birth dose of hepatitis B vaccine (HepB(1)) vaccination. Methods: Based on the data from 160 disease surveillance points in 31 provinces of China, two-stage cluster random sampling was used to select the target population aged 1-4 years. A standard questionnaire was used to collect the information about the birth date, gender, ethnic group, place of birth, HepB immunization history of the children selected...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28100325/-an-investigation-of-dietary-nutrition-in-kindergartens-of-chongqing-china
#20
Xia Liu, Xin Fan
OBJECTIVE: To investigate the status of dietary nutrition in kindergartens of Chongqing, China. METHODS: A total of 295 kindergartens (47 first-class ones, 88 second-class ones, and 160 third-class ones) from the 11 districts or counties of Chongqing by stratified cluster random sampling were investigated. The dietary nutrition in each kindergarten was evaluated by weighing. The dietary qualification rates were compared between the three classes of kindergartens...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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