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https://www.readbyqxmd.com/read/28453828/examining-the-nature-of-interprofessional-interventions-designed-to-promote-patient-safety-a-narrative-review
#1
Scott Reeves, Emma Clark, Sally Lawton, Melissa Ream, Fiona Ross
Purpose: This narrative review aimed to scope the patient safety literature to identify interprofessional intervention approaches, sources of evidence and reported outcomes. Data sources: Two major databases (MEDLINE and CINAHL) were searched from 2005 to 2015. Study selection: A total of 1552 abstracts were initially identified. After screening these abstracts, 129 full papers were obtained. Further screening resulted in a total of 89 papers included in this review...
April 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28453666/inequalities-in-rural-communities-adapting-national-deprivation-indices-for-rural-settings
#2
D Fecht, A Jones, T Hill, T Lindfield, R Thomson, A L Hansell, R Shukla
Background: Deprivation indices have been widely used in healthcare research and planning in the United Kingdom. Existing indices, however, are dominated by characteristics of urban populations that may be less relevant in capturing the nature of rural deprivation. We explore if deprivation indices can be modified to make them more sensitive to displaying rural disadvantage in England. Methods: The analysis focussed on the 2011 Carstairs Index (Carstairs2011) and the 2010 English Index of Multiple Deprivation (IMD2010)...
April 27, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28449469/cd90-positive-cells-exhibit-aggressive-radioresistance-in-esophageal-squamous-cell-carcinoma
#3
Yuandong Wang, Chi Zhang, Hongcheng Zhu, Junwei Tang, Shu Zhang, Jinhua Luo, Xinchen Sun
BACKGROUND: Cancer stem cells (CSCs) are widely abundant and considered to be an important factor in therapy resistance. They are also promising potential targets for conquering tumors. We explored the effects of radiation on stem cell-like tumor cells via the candidate marker CD90 to provide new ideas for the comprehensive treatment of esophageal squamous cell carcinoma (ESCC). METHODS: We constructed CD90 overexpression ESCC cells by lentiviral transfection and observed differences of toxicity, proliferation, clone number, apoptosis, migration, invasion, and in vivo tumor formation after irradiation...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449225/transfusion-research-priorities-for-blood-services-in-sub-saharan-africa
#4
REVIEW
Imelda Bates, Oliver Hassall, Tonderai Mapako
Evidence to support many blood transfusion policies and practices in sub-Saharan Africa (SSA) is weak or lacking. SSA cannot extrapolate from wealthy countries' research findings because its environment, users and structures are very different and SSA has critical blood shortages. SSA needs to generate its own evidence but research funds are very scarce and need to be carefully targeted to match need. This study aimed to define this need by determining research priorities for blood services in SSA. Thirty-five stakeholders representing diverse blood services' interests and expertise participated in a workshop...
April 27, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28448914/reconciling-agriculture-and-stream-restoration-in-europe-a-review-relating-to-the-eu-water-framework-directive
#5
REVIEW
H M Flávio, P Ferreira, N Formigo, J C Svendsen
Agriculture is widespread across the EU and has caused considerable impacts on freshwater ecosystems. To revert the degradation caused to streams and rivers, research and restoration efforts have been developed to recover ecosystem functions and services, with the European Water Framework Directive (WFD) playing a significant role in strengthening the progress. Analysing recent peer-reviewed European literature (2009-2016), this review explores 1) the conflicts and difficulties faced when restoring agriculturally impacted streams, 2) the aspects relevant to effectively reconcile agricultural land uses and healthy riverine ecosystems and 3) the effects and potential shortcomings of the first WFD management cycle...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448784/a-motivational-interviewing-intervention-by-pharmacy-students-to-improve-medication-adherence
#6
Susan Abughosh, Xin Wang, Omar Serna, Tara Esse, Amanda Mann, Santhi Masilamani, Marcia McDonnell Holstad, Ekere James Essien, Marc Fleming
BACKGROUND: Diabetes mellitus (DM) patients with comorbid hypertension (HTN) are at a higher risk of developing microvascular and macrovascular DM complications. Through guideline-driven recommendations, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are highly recommended for these patients. Unfortunately, medication adherence to these products, though crucial to achieving therapeutic benefit, is frequently suboptimal. Motivational interviewing (MI) is a patient-centered collaborative communication style that is used to strengthen internal motivation for change that may prove effective in enhancing adherence...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28448736/orphan-cpg-islands-define-a-novel-class-of-highly-active-enhancers
#7
Joshua S K Bell, Paula M Vertino
CpG islands (CGI) are critical genomic regulatory elements that support transcriptional initiation and are associated with the promoters of most human genes. CGI are distinguished from the bulk genome by their high CpG density, lack of DNA methylation, and euchromatic features. While CGI are canonically known as strong promoters, thousands of 'orphan' CGI lie far from any known transcript, leaving their function an open question. We undertook a comprehensive analysis of the epigenetic state of orphan CGI across over 100 cell types...
April 27, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28448592/blood-type-abo-genetic-variants-and-ovarian-cancer-survival
#8
Gabriella D Cozzi, Rebecca T Levinson, Hilary Toole, Malcolm-Robert Snyder, Angie Deng, Marta A Crispens, Dineo Khabele, Alicia Beeghly-Fadiel
OBJECTIVE: Blood type A and the A1 allele have been associated with increased ovarian cancer risk. With only two small studies published to date, evidence for an association between ABO blood type and ovarian cancer survival is limited. METHODS: We conducted a retrospective cohort study of Tumor Registry confirmed ovarian cancer cases from the Vanderbilt University Medical Center with blood type from linked laboratory reports and ABO variants from linked Illumina Exome BeadChip data...
2017: PloS One
https://www.readbyqxmd.com/read/28448589/morpho-physiological-analysis-of-tolerance-to-aluminum-toxicity-in-rice-varieties-of-north-east-india
#9
Jay Prakash Awasthi, Bedabrata Saha, Preetom Regon, Smita Sahoo, Umakanta Chowra, Amit Pradhan, Anupam Roy, Sanjib Kumar Panda
Aluminum (Al) is the third most abundant metal in earth crust, whose chemical form is mainly dependent on soil pH. The most toxic form of Al with respect to plants is Al3+, which exists in soil pH <5. Acidic soil significantly limits crop production mainly due to Al3+ toxicity worldwide, impacting approximately 50% of the world's arable land (in North-Eastern India 80% soil are acidic). Al3+ toxicity in plants ensues root growth inhibition leading to less nutrient and water uptake impacting crop productivity as a whole...
2017: PloS One
https://www.readbyqxmd.com/read/28448523/semaphorin-1a-prevents-drosophila-olfactory-projection-neuron-dendrites-from-mis-targeting-into-select-antennal-lobe-regions
#10
Hung-Chang Shen, Sao-Yu Chu, Tsai-Chi Hsu, Chun-Han Wang, I-Ya Lin, Hung-Hsiang Yu
Elucidating how appropriate neurite patterns are generated in neurons of the olfactory system is crucial for comprehending the construction of the olfactory map. In the Drosophila olfactory system, projection neurons (PNs), primarily derived from four neural stem cells (called neuroblasts), populate their cell bodies surrounding to and distribute their dendrites in distinct but overlapping patterns within the primary olfactory center of the brain, the antennal lobe (AL). However, it remains unclear whether the same molecular mechanisms are employed to generate the appropriate dendritic patterns in discrete AL glomeruli among PNs produced from different neuroblasts...
April 27, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28448486/-first-mexican-consensus-of-vaccination-in-adults
#11
Luis Miguel Gutiérrez-Robledo, Elizabeth Caro-López, María de Lourdes Guerrero-Almeida, Margarita Dehesa-Violante, Eduardo Rodríguez-Noriega, Juan Miguel García-Lara, Zaira Medina-López, Renata Báez-Saldaña, Elsa Díaz-López, Flor Maria de Guadalupe Avila-Fematt, Miguel Betancourt-Cravioto, Lourdes Garcia-Garcia
For years our efforts have been focused on vaccination during childhood. Today we know that this is not enough to ensure health in the rest of the life. Childhood is as important as any other stage and, therefore, vaccination must be permanent and differentiated, according to our age, throughout life. Introducing a life course perspective in vaccination programs, with emphasis on adult vaccination, particularly in older adults, offers us the opportunity to review the performance of health programs, actions, and services in the field of immunization, as well as strengthening health promotion actions...
March 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28447879/the-lived-experience-of-caregivers-of-persons-with-heart-failure-a-phenomenological-study
#12
Antonio Petruzzo, Marco Paturzo, Monica Naletto, Marlene Z Cohen, Rosaria Alvaro, Ercole Vellone
BACKGROUND: Heart failure (HF) patients need to follow a strict pharmacological and nonpharmacological regimen in order to counteract the burden of the disease, and informal caregivers are an important resource for HF patients in managing and coping with their disease. Few studies have examined the lived experience of these caregivers with a rigorous phenomenological approach, and none have been conducted in Italy. AIM: To describe the lived experience of the caregivers of HF patients...
April 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28447639/frequency-of-extreme-sahelian-storms-tripled-since-1982-in-satellite-observations
#13
Christopher M Taylor, Danijel Belušić, Françoise Guichard, Douglas J Parker, Théo Vischel, Olivier Bock, Phil P Harris, Serge Janicot, Cornelia Klein, Gérémy Panthou
The hydrological cycle is expected to intensify under global warming, with studies reporting more frequent extreme rain events in many regions of the world, and predicting increases in future flood frequency. Such early, predominantly mid-latitude observations are essential because of shortcomings within climate models in their depiction of convective rainfall. A globally important group of intense storms-mesoscale convective systems (MCSs)-poses a particular challenge, because they organize dynamically on spatial scales that cannot be resolved by conventional climate models...
April 26, 2017: Nature
https://www.readbyqxmd.com/read/28447582/training-the-next-generation-of-canadian-clinician-scientists-charting-a-path-to-success
#14
Charles Yin, Patrick E Steadman, Tavis Apramian, Tianwei E Zhou, Abdullah Ishaque, Xin Wang, Alexandra Kuzyk, Nebras Warsi
Clinician-scientists are physicians with training in both clinical medicine and research that enables them to occupy a unique niche as specialists in basic and translational biomedical research. While there is widespread acknowledgement of the importance of clinician-scientists in today's landscape of evidence-based medical practice, training of clinician-scientists in Canada has been on the decline, with fewer opportunities to obtain funding. With the increasing length of training and lower financial compensation, fewer medical graduates are choosing to pursue such a career...
April 26, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28447184/electromyographic-evaluation-of-high-intensity-elastic-resistance-exercises-for-lower-extremity-muscles-during-bed-rest
#15
Jonas Vinstrup, Sebastian Skals, Joaquin Calatayud, Markus Due Jakobsen, Emil Sundstrup, Matheus Daros Pinto, Mikel Izquierdo, Yuling Wang, Mette K Zebis, Lars Louis Andersen
PURPOSE: Prolonged hospital bed rest after severe injury or disease leads to rapid muscle atrophy and strength loss. Therefore, the main aim of this study was to evaluate the efficacy of lower extremity strengthening exercises using elastic resistance that can be performed while lying in a hospital bed. METHODS: Using a cross-sectional design, 22 healthy individuals performed three consecutive repetitions of 14 different lower extremity exercises using elastic resistance, with a perceived intensity corresponding to 8 on the Borg CR-10 scale...
April 26, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28446885/the-impact-of-inattention-hyperactivity-impulsivity-symptoms-and-executive-functions-on-learning-behaviors-of-children-with-adhd
#16
Carla Colomer, Carmen Berenguer, Belén Roselló, Inmaculada Baixauli, Ana Miranda
Children diagnosed with attention deficit/hyperactivity disorder (ADHD) are at risk of experiencing lower academic achievement compared to their peers without ADHD. However, we have a limited understanding of the mechanisms underlying this association. Both the symptoms of the disorder and the executive functions can negatively influence learning behaviors, including motivation, attitude toward learning, or persistence, key aspects of the learning process. The first objective of this study was to compare different components of learning behaviors in children diagnosed with ADHD and typically developing (TD) children...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28446864/neural-entrainment-to-polyrhythms-a-comparison-of-musicians-and-non-musicians
#17
Jan Stupacher, Guilherme Wood, Matthias Witte
Music can be thought of as a dynamic path over time. In most cases, the rhythmic structure of this path, such as specific sequences of strong and weak beats or recurring patterns, allows us to predict what and particularly when sounds are going to happen. Without this ability we would not be able to entrain body movements to music, like we do when we dance. By combining EEG and behavioral measures, the current study provides evidence illustrating the importance of ongoing neural oscillations at beat-related frequencies-i...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28446752/near-atomic-structure-of-japanese-encephalitis-virus-reveals-critical-determinants-of-virulence-and-stability
#18
Xiangxi Wang, Shi-Hua Li, Ling Zhu, Qing-Gong Nian, Shuai Yuan, Qiang Gao, Zhongyu Hu, Qing Ye, Xiao-Feng Li, Dong-Yang Xie, Neil Shaw, Junzhi Wang, Thomas S Walter, Juha T Huiskonen, Elizabeth E Fry, Cheng-Feng Qin, David I Stuart, Zihe Rao
Although several different flaviviruses may cause encephalitis, Japanese encephalitis virus is the most significant, being responsible for thousands of deaths each year in Asia. The structural and molecular basis of this encephalitis is not fully understood. Here, we report the cryo-electron microscopy structure of mature Japanese encephalitis virus at near-atomic resolution, which reveals an unusual "hole" on the surface, surrounded by five encephalitic-specific motifs implicated in receptor binding. Glu138 of E, which is highly conserved in encephalitic flaviviruses, maps onto one of these motifs and is essential for binding to neuroblastoma cells, with the E138K mutation abrogating the neurovirulence and neuroinvasiveness of Japanese encephalitis virus in mice...
April 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28446569/differentiated-levels-of-ganciclovir-resistance-conferred-by-mutations-at-codons-591-603-of-the-cytomegalovirus-ul97-kinase-gene
#19
Sunwen Chou, Ronald J Ercolani, Adam L Vanarsdall
Diagnostic mutations in the cytomegalovirus UL97 kinase gene are used to assess the level of associated ganciclovir resistance and therapeutic options. The best-known mutations at codons 460, 520 or 591-607 individually confer 5- to 10-fold decreased ganciclovir susceptibility, except 3-fold in the case of amino acid substitution C592G. Less common point and in-frame deletion mutations at codons 591-603 remain incompletely characterized. The ganciclovir susceptibilities of 17 mutants in this codon range were evaluated by use of the same recombinant phenotyping system and extensive assay replicates in two types of cell cultures...
April 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28446523/evaluation-of-the-coping-parent-online-universal-programme-study-protocol-for-a-pilot-randomised-controlled-trial
#20
Dawn Adele Owen, Nia Griffith, Judy Hutchings
TRIAL SPONSOR: Bangor University, Brigantia Building, College Road, Bangor, LL57 2AS, UK INTRODUCTION: The COPING parent online universal programme is a web-based parenting intervention for parents of children aged 3-8 years with an interest in positive parenting. The programme focuses on strengthening parent-child relationships and encouraging positive child behaviour. This trial will evaluate whether the intervention is effective in increasing the use of positive parenting strategies outlined in the programme using parent report and blind observation measures...
April 26, 2017: BMJ Open
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