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https://www.readbyqxmd.com/read/28210239/flow-diversion-for-the-treatment-of-mca-bifurcation-aneurysms-a-single-centre-experience
#1
Pervinder Bhogal, Muhammad AlMatter, Hansjörg Bäzner, Oliver Ganslandt, Hans Henkes, Marta Aguilar Pérez
BACKGROUND: Intracranial aneurysms located at the bifurcation of the middle cerebral artery (MCA) can often be challenging for the neurointerventionalist. We aimed to evaluate the efficacy and safety of flow diverting stents (FDS) in the treatment of these aneurysms. MATERIALS AND METHODS: We retrospectively reviewed our prospectively maintained database to collect information for all patients with unruptured saccular bifurcation MCA aneurysms treated with FDS between January 2010 and January 2016...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28209579/patterns-of-brain-injury-in-newborns-treated-with-extracorporeal-membrane-oxygenation
#2
M A Wien, M T Whitehead, D Bulas, M Ridore, L Melbourne, G Oldenburg, B L Short, A N Massaro
BACKGROUND AND PURPOSE: Neonates treated with extracorporeal membrane oxygenation are at risk for brain injury and subsequent neurodevelopmental compromise. Advances in MR imaging and improved accessibility have led to the increased use of routine MR imaging after extracorporeal membrane oxygenation. Our objective was to describe the frequency and patterns of extracorporeal membrane oxygenation-related brain injury based on MR imaging findings in a large contemporary cohort of neonates treated with extracorporeal membrane oxygenation...
February 16, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28209313/the-arborization-bypass-sequential-intracranial-intracranial-bypasses-for-an-unruptured-fusiform-mca-aneurysm
#3
Jonathan J Russin
Revascularization techniques are being featured more prominently as endovascular treatments continue to select out complex cerebrovascular pathologies for open surgical management. The current healthcare environment requires decreased hospital stays and improved clinical outcomes despite the growing complexity of open surgical cases. Recent efforts to reduce operative room time and decrease risk for bypass surgery have focused on avoiding graft harvest and maintaining the entire bypass intracranial. The presented technique features an arborization bypass to serially anastomose the middle cerebral artery vessels allowing for proximal trapping of a complex aneurysm without graft harvest...
February 10, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28208858/approach-to-carbapenemase-detection-in-klebsiella-pneumoniae-in-routine-diagnostic-laboratories
#4
Rangnekar Aseem, Shalini Shenoy, Suchitra Shenoy Mala, Shrikala Baliga, Agarwal Ashish
INTRODUCTION: Resistance to Carbapenems in Klebsiella may be due to Carbapenem hydrolysing enzymes. Accurate detection of carbapenemase must be done for patient treatment and epidemiological purposes. AIM: To detect carbapenemase production by performing Modified Hodge Test (MHT), Combined Disk Test (CDT) for Metallo-β-Lactamases (MBL) and PCR for blaKPC gene, to evaluate the performance of MHT using MacConkey Agar (MCA) and to access the value of MHT for carbapenemase detection...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208149/distal-middle-cerebral-artery-branch-recanalization-does-not-affect-final-lesion-volume-in-ischemic-stroke
#5
Verena van Ginneken, Daniel Gierhake, Heinrich J Audebert, Jochen B Fiebach
BACKGROUND: Early recanalization in ischemic stroke is associated with favorable outcome. However, limited data are available on the effect of recanalization on infarct growth and functional outcome in stroke with distal middle cerebral artery (MCA) pathology. This study was aimed at determining the effect of recanalization in acute stroke patients with perfusion-diffusion mismatch and occlusion or high-grade stenosis of a distal MCA branch. METHODS: We prospectively examined 34 consecutive stroke patients with perfusion-diffusion mismatch and M3 or M4 pathology within 24 h of symptom onset...
February 17, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28208130/factors-related-to-cardioembolism-as-major-predictors-of-poor-survival-after-first-ever-middle-cerebral-artery-stroke-treated-with-thrombolysis
#6
Renata Dal-Prá Ducci, Marcos Christiano Lange, Viviane de Hiroki Flumignan Zétola, Tatjana Rundek
BACKGROUND AND PURPOSE: Prognostic factors related to mortality rates after stroke have been reported; however, most studies included different treatments and did not focus solely on ischemic stroke. The study aimed to report the short- and long-term survival and predictors of death in patients with first-ever ischemic stroke in the middle cerebral artery (MCA) territory, submitted to intravenous thrombolysis (IVT). METHODS: A prospective observational cohort study of patients with first-ever ischemic stroke in the MCA territory treated with IVT from March 2010 to February 2015 was conducted, and patients were followed up until May 2015...
February 17, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28202335/purification-and-characterization-of-a-milk-clotting-aspartic-protease-from-withania-coagulans-fruit
#7
Mahmoud Salehi, Mahmoud Reza Aghamaali, Reza H Sajedi, S Mohsen Asghari, Eisa Jorjani
Withania coagulans fruit has traditionally been used as milk coagulant. The present study reports the purification and characterization of an aspartic protease from W. coagulans fruit. The enzyme was purified via fractional ammonium sulfate precipitation and cation exchange chromatography. SDS-PAGE analysis revealed the presence of a monomeric protein with molecular weight of 31kDa. Proteolytic activity (PA) of the protease was evaluated using casein, and the milk-clotting activity (MCA) was analyzed by skim milk...
February 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28199398/a-segmentation-based-volumetric-approach-to-localize-and-quantify-cerebral-vasospasm-based-on-tomographic-imaging-data
#8
Axel Neulen, Tobias Pantel, Michael Kosterhon, Stefanie Kirschner, Marc A Brockmann, Sven R Kantelhardt, Alf Giese, Serge C Thal
INTRODUCTION: Quantification of cerebral vasospasm after subarachnoid hemorrhage (SAH) is crucial in animal studies as well as clinical routine. We have developed a method for computer-based volumetric assessment of intracranial blood vessels from cross-sectional imaging data. Here we demonstrate the quantification of vasospasm from micro computed tomography (micro-CT) data in a rodent SAH model and the transferability of the volumetric approach to clinical data. METHODS: We obtained rodent data by performing an ex vivo micro-CT of murine brains after sham surgery or SAH by endovascular filament perforation on day 3 post hemorrhage...
2017: PloS One
https://www.readbyqxmd.com/read/28195485/birefringent-pattern-formation-in-photo-inactive-liquid-crystalline-polymer-films-based-on-a-photoalignment-technique-with-top-coating-of-cinnamic-acid-derivatives-via-h-bonds
#9
Nobuhiro Kawatsuki, Ryosuke Fujii, Yu Fujioka, Satoshi Minami, Mizuho Kondo
The application of a top-coating of 4-methoxy cinnamic acid (MCA) onto a photo-inactive liquid crystalline polymeric films containing benzoic acid (BA) side groups (P6BAM) is shown to enable thermally stimulated, photoinduced reorientation of the polymer structure. Annealing the MCA-coated P6BAM films leads to H-bond formation between BA and MCA, which also effectively smooths film surface. Exposure to linearly polarized (LP) UV light initiates axis-selective photoreaction of the MCA groups; subsequent thermal treatment in the LC temperature range of P6BAM amplifies molecular reorientation of the BA side groups, while simultaneously eliminating the MCA molecules...
February 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28194221/a-removal-of-eye-movement-and-blink-artifacts-from-eeg-data-using-morphological-component-analysis
#10
Balbir Singh, Hiroaki Wagatsuma
EEG signals contain a large amount of ocular artifacts with different time-frequency properties mixing together in EEGs of interest. The artifact removal has been substantially dealt with by existing decomposition methods known as PCA and ICA based on the orthogonality of signal vectors or statistical independence of signal components. We focused on the signal morphology and proposed a systematic decomposition method to identify the type of signal components on the basis of sparsity in the time-frequency domain based on Morphological Component Analysis (MCA), which provides a way of reconstruction that guarantees accuracy in reconstruction by using multiple bases in accordance with the concept of "dictionary...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28193478/metabolic-cold-adaptation-contributes-little-to-the-interspecific-variation-in-metabolic-rates-of-65-species-of-drosophilidae
#11
Branwen Messamah, Vanessa Kellermann, Hans Malte, Volker Loeschcke, Johannes Overgaard
Metabolic cold adaptation (MCA) is a controversial hypothesis suggesting that cold adapted species display an elevated metabolic rate (MR) compared to their warm climate relatives. Here we test for the presence of MCA within 65 species of drosophilid flies reared under common garden conditions. MR was measured at both 10 and 20°C for both sexes and data was analyzed in relation to the natural thermal environment of these species. We found considerable interspecific variation in MR ranging from 1.34 to 8.99 µW mg(-1) at 10°C...
February 10, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28193423/effect-of-extraction-ph-on-techno-functional-properties-of-crude-extracts-from-wild-cardoon-cynara-cardunculus-l-flowers
#12
Amal Ben Amira, Ines Makhlouf, Raul Flaviu Petrut, Frédéric Francis, Julien Bauwens, Hamadi Attia, Souhail Besbes, Christophe Blecker
In the present paper, techno-functional properties of rennet derived from C. cardunculus, prepared at various pH (from 3 to 6), were investigated. It was found that the extract prepared at pH 3 had the best milk-clotting properties (MCA/PA ratio). It presented also the highest enzyme content, determined by densitometry analysis on 1D and 2D gels electrophoresis. Formation of milk gels produced by the extracts and chymosin was monitored using dynamic rheology and turbiscan. It can be assumed that by lowering rennet pH, milk pH decreases, causing a significant increase of curd firmness and both elastic (G') and viscous (G″) moduli...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28192099/role-of-interleukin-10-in-the-neuroprotective-effect-of-the-angiotensin-type-2-receptor-agonist-compound-21-after-ischemia-reperfusion-injury
#13
Abdelrahman Y Fouda, Bindu Pillai, Krishnan M Dhandapani, Adviye Ergul, Susan C Fagan
INTRODUCTION: We and others have shown that the angiotensin type 2 (AT2) receptor agonist, compound 21 (C21), provides neuroprotection and enhances recovery in rodent stroke models yet the mechanism involved is not known. Moreover, C21 treatment is associated with an anti-inflammatory response. Here we tested the hypothesis that C21 mediates neuroprotection by upregulating the neuroprotective and anti-inflammatory cytokine interleukin (IL)-10. METHODS: Wistar rats were subjected to 3h MCA suture occlusion and treated at reperfusion with C21 (0...
February 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28191623/the-ivy-sign-on-fluid-attenuated-inversion-recovery-images-related-to-single-photon-emission-computed-tomography-cerebral-blood-flow-in-moyamoya-disease-a-case-report
#14
Fumihiro Matano, Yasuo Murai, Asami Kubota, Takayuki Mizunari, Shiro Kobayashi, Akio Morita
BACKGROUND: Moyamoya disease is an idiopathic progressive cerebrovascular steno-occlusive disorder characterized by the formation of numerous collaterals called moyamoya vessels. Accurate evaluation of vascular status and CBF is needed for prompt treatment to prevent ischemic and/or hemorrhagic events. The pathogenesis of the ivy sign on fluid attenuated inversion recovery (FLAIR) images of moyamoya disease patients is unclear. We report a moyamoya disease case wherein the ivy sign changed in relation to SPECT-measured CBF during progression and following treatment...
January 17, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28181086/bilateral-cavernous-carotid-aneurysms-treated-by-two-stage-extracranial-intracranial-bypass-followed-by-parent-artery-occlusion-case-report-and-literature-review
#15
Yaoling Liu, Xiang'en Shi, Fangjun Liu, Yuming Sun, Hai Qian, Ting Lei
Bilateral cavernous carotid aneurysms (CCAs) are often not amenable to neurosurgical clipping or endovascular coiling. Here, we report the case of a 50-year-old female who presented with a 1-year history of gradual severe headache. Preoperative angiograms revealed bilateral CCAs. Among these findings, the right giant CCA had been trapped after the external carotid artery-saphenous vein-middle cerebral artery (ECA-SV-MCA) bypass 8 years prior. Additionally, the left CCA was again trapped after the internal maxillary artery-radial artery-middle cerebral artery (IMA-RA-MCA) bypass, followed by parent artery occlusion (PAO), because of the enlargement of a 0...
February 8, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28178170/use-of-susceptibility-weighted-imaging-in-assessing-ischemic-penumbra-a-case-report
#16
Xiujuan Wu, Song Luo, Ying Wang, Yang Chen, Jun Liu, Jing Bai, Jiachun Feng, Hongliang Zhang
RATIONALE: The ischemic penumbra assessment is essential for the subsequent therapy and prediction of evolution in patients with acute ischemic infraction. Although controversial as a perfect equivalence to penumbra, perfusion-weighted imaging (PWI)-diffusion-weighted imaging (DWI) mismatch may predict the response to thrombolysis. Due to the reliance of PWI on contrast agents, noninvasive alternatives remain an unmet need. PATIENT CONCERNS: We reported a 65-year-old man complained of paroxysmal hemiplegia of his right limbs and anepia for 2 days, whereas the symptoms lasted for about 12 hours when he admitted to the hospital...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28177619/correction-to-determining-the-extent-of-biodegradation-of-fuels-using-the-diastereomers-of-acyclic-isoprenoids
#17
Cameron P McIntyre, Paul McA Harvey, Susan Ferguson, Anna M Wressnig, Herbert Volk, Simon C George, Ian Snape
No abstract text is available yet for this article.
February 8, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28165757/cerebral-regions-preserved-by-successful-endovascular-recanalization-of-acute-m1-segment-occlusions-a-voxel-based-analysis
#18
Seyedmehdi Payabvash, Shayandokht Taleb, Adnan I Qureshi
OBJECTIVES: To identify cerebral regions preserved by successful recanalization of middle cerebral artery (MCA) M1 segment, and their association with early clinical outcome. METHODS: Forty-seven patients who underwent endovascular treatment for acute unilateral M1 segment occlusion were included. Successful recanalization was defined by a modified Thrombolysis in Cerebral Infarction (mTICI) score of 2b/3. Final infarct volumes were segmented on follow-up MRI/CT, 2-7 days post symptom onset...
February 6, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28163065/a-standardized-method-to-measure-brain-shifts-with-decompressive-hemicraniectomy
#19
Askiel Bruno, Abdurrehman Zahran, Nina Paletta, Laith Maali, Fenwick T Nichols, Ramon Figueroa
BACKGROUND: A standardized, reliable, and practical method for measuring decompressive hemicraniectomy (DHC) defects and brain shifts in malignant middle cerebral artery (MCA) territory infarction is needed for reliable comparisons between computed tomography (CT) scans. Such a method could facilitate further studies on the effects of DHC. NEW METHOD: We describe and apply a method for measuring DHC defects and brain shifts on CT scans in 25 patients with malignant MCA territory infarction...
February 2, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28151901/coexistence-of-intracranial-epidermoid-tumor-and-multiple-cerebral-aneurysms-a-case-report-and-literature-review
#20
Pei-Sen Yao, Zhang-Ya Lin, Shu-Fa Zheng, Yuan-Xiang Lin, Liang-Hong Yu, Chang-Zhen Jiang, De-Zhi Kang
RATIONALE: There were a few case reports concerning epidermoid tumor coexisted with multiple cerebral aneurysms. Here, we present one case of coexistence of intracranial epidermoid tumor and multiple cerebral aneurysms and performed a literature review. PATIENT CONCERNS: A 42 years old male patient was admitted to our institution with complaints of headache and dizziness. INTERVENTIONS: The radiological examinations showed a hypointense lesion in the right parasellar and petrous apex region and an ipsilateral saccular aneurysm originated from the M2-M3 junction of the right middle cerebral artery (MCA) and a saccular aneurysm of the clinoid segment of right internal carotid artery (ICA)...
February 2017: Medicine (Baltimore)
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