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https://www.readbyqxmd.com/read/29458087/ngf-fak-signal-pathway-is-implicated-in-angiogenesis-after-acute-cerebral-ischemia-in-rats
#1
Hai-Ting Zhao, Yu-Hu Zhang, Ying-Hui Zhang, Yue Shen, Yi-Dan Zhang, Fang-Fang Bi, Bo Xiao, Hao Zhang, Wen Ye, Hong-Hai Zhang, Yi-Wei Liao
Neurogenesis in the cerebral infarction after an ischemic event is important to the rehabilitation of patients. However, the mechanism of angiogenesis around cerebral ischemia is not clear. Our study designed to test whether the nerve growth factor (NGF)-P-focal adhesion kinase (FAK) signaling pathway for associations with angiogenesis plays a key role in post-acute cerebral ischemia of rats. Firstly, we implanted the Matrigel, a carrier of basement membrane matrix, into the abdominal skin of rats to identify the relevant components of the NGF-P-FAK signaling pathway related to angiogenesis...
February 16, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29455906/clinical-analysis-of-combined-revascularization-in-treating-ischemic-moyamoya-disease-in-adults
#2
Z Chen, L Zhang, J Qu, Y Wu, G Mao, X Zhu, J Zhu
OBJECTIVE: The aim of this study was to investigate the clinical efficacy of superficial temporal artery-middle cerebral artery anastomosis (STA-MCA)+encephalo-duro-myo-synangiosis (EDMS) in treating ischemic Moyamoya disease (IMD) in adults. METHODS: A total of 30 adult patients with IMD were selected to be included in the study; they underwent STA-MCA+EDMS and were followed up for 3 months to 2 years. The digital subtraction angiography findings, modified Rankin scale (mRs) score, and complications of all the patients were compared...
February 15, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29455049/poststroke-epilepsy-following-transient-unilateral-middle-cerebral-and-common-carotid-artery-occlusion-in-young-adult-and-aged-f344-rats
#3
Kevin M Kelly, Peter I Jukkola, Guo Yin, Eric R Miller, Elena A Kharlamov, Deng-Shan Shiau, Roger Strong, Jaroslaw Aronowski
The mechanisms of injured brain that establish poststroke seizures and epilepsy are not well understood, largely because animal modeling has had limited development. The main objective of this study was to determine whether an arterial occlusion model of cortical stroke in young adult and aged rats was capable of generating either focal or generalized epileptic seizures within 2 months of lesioning. Four- and 20-month-old male Fischer 344 (F344) sham-operated controls and those lesioned by transient (3 h) unilateral middle cerebral artery (MCA) and common carotid artery (CCA) occlusion (MCA/CCAo) were studied by video-EEG recordings up to 2 months post-procedure...
February 10, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29451821/protection-from-vascular-dysfunction-in-female-rats-with-chronic-stress-and-depressive-symptoms
#4
Steven D Brooks, Stan Hileman, Paul D Chantler, Samantha Milde, Kent C Lemaster, Stephanie Frisbee, J Kevin Shoemaker, Dwayne N Jackson, Jefferson C Frisbee
The increasing prevalence and severity of clinical depression is strongly correlated with vascular disease risk, creating a comorbid condition with poor outcomes, although demonstrating a sexual disparity where females are at lower risk than males for subsequent cardiovascular events. To determine potential mechanisms responsible for this protection against stress/depression-induced vasculopathy in females, we exposed male and female ({plus minus}ovariectomy) rats to the unpredictable chronic mild stress (UCMS) model for 8 weeks and determined depressive symptom severity, vascular reactivity in aortic rings (AR) and ex vivo middle cerebral arteries (MCA), and determined the profile of major metabolites regulating vascular tone...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29449517/-a-case-of-moyamoya-disease-with-postoperative-cerebral-hyperperfusion-syndrome-followed-by-cerebral-infarction-due-to-watershed-shift
#5
Kimitoshi Sato, Shun Tsudaka, Takanori Miki, Norikata Kobayashi, Taro Yamashita, Kiyoharu Imataka, Takashi Yoshida, Fuminori Shimizu
The concept of "watershed shift"(WS)has been proposed as a cause of the ischemic complications following a superficial temporal artery-middle cerebral artery(STA-MCA)bypass operation performed for the management of moyamoya disease. Previous reports have observed that only 1.2-5.7% of the patients who underwent a bypass operation for the management of moyamoya disease developed cerebral infarction secondary to the WS phenomenon. To date, the WS phenomenon has not been objectively proven on imaging studies...
February 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29447827/a-novel-approach-for-comparing-patterns-of-foreign-body-injuries-across-countries-a-case-study-comparing-european-countries-and-bosnia-and-herzegovina
#6
Giulia Lorenzoni, Sekib Umihanić, Danila Azzolina, Emiliano Manza, Fuad Brkić, Dario Gregori
OBJECTIVES: The present study aimed at analyzing the characteristics of FB injuries from Bosnia and Herzegovina (B&H), a rapidly growing newly industrialized country, and to compare them with cases from European countries. METHODS: The analysis is based on FB injury cases included in the Susy Safe registry. Cases from the Ear-Nose-Throat (ENT) Clinic, University Clinical Center of Tuzla (B&H) were compared with cases from European countries participating in the Susy Safe project...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29444960/stent-assisted-coil-embolization-on-down-the-barrel-view-with-spring-shaped-microcatheter-in-patient-with-m1-ultrawide-necked-circumferential-aneurysm
#7
Hyo Sung Kwak, Jung Soo Park, Eun Jeong Koh
Herein, we describe a technique for stent-assisted coil embolization with a spring-shaped microcatheter in a patient with an M1 ultrawide-necked circumferential aneurysm in the middle cerebral artery (MCA). A 49-year-old man was referred for treatment of an incidentally detected M1 large-circumference aneurysm on magnetic resonance angiography. Subsequent digital subtraction angiography revealed an 18.2×16.5 mm ultrawide-necked circumferential aneurysm on the distal M1 portion of the left MCA, and we planned stent-assisted coil embolization using a spring-shaped microcatheter...
February 14, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29440356/arterial-diameter-and-the-gender-disparity-in-stroke-thrombectomy-outcomes
#8
Mark A Davison, Bichun Ouyang, Kavantissa M Keppetipola, Michael Chen
BACKGROUND: Compared with males, females consistently fare worse following mechanical thrombectomy for large vessel ischemic strokes. Understanding why this gender disparity occurs may guide improvements in future treatment strategies. In this study, we aim to determine whether gender differences in cerebral arterial diameter correlate with clinical outcomes following stroke thrombectomy. METHODS: We performed an observational study of consecutive acute ischemic stroke patients undergoing mechanical thrombectomy at a single, urban tertiary care medical center...
February 12, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29439905/three-dimensional-intracranial-middle-cerebral-artery-aneurysm-models-for-aneurysm-surgery-and-training
#9
Liang Wang, Xun Ye, Qiang Hao, Li Ma, Xiaolin Chen, Hao Wang, Yuanli Zhao
To develop a realistic model of middle cerebral artery (MCA) aneurysms using three-dimensional (3D) printing for surgical planning, research, and training of neurosurgical residents. This study included eight MCA aneurysm cases. The aneurysm together with the adjacent arteries and skull base were printed based on raw computed tomography angiography (CTA) data using a 3D printer with acrylonitrile-butadiene-styrene as the model material. The aneurysm models were used for surgical planning, and craniotomy and clipping practice by neurosurgical residents...
February 10, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29439126/mechanical-thrombectomy-of-acute-ischemic-stroke-with-a-new-intermediate-aspiration-catheter-preliminary-results
#10
Fabrizio Sallustio, Enrico Pampana, Alessandro Davoli, Stefano Merolla, Giacomo Koch, Fana Alemseged, Marta Panella, Vittoria Carla D'Agostino, Francesco Mori, Daniele Morosetti, Daniel Konda, Sebastiano Fabiano, Marina Diomedi, Roberto Gandini
BACKGROUND AND PURPOSE: To report clinical and procedural outcomes of acute ischemic stroke patients after endovascular treatment with the new thromboaspiration catheter AXS Catalyst 6. METHODS: Patients with anterior and posterior circulation stroke were selected. Successful reperfusion defined as a Thrombolysis in Cerebral Infarction (TICI) score ≥2 b and 3-month functional independence defined as a modified Rankin Scale (mRS) ≤2 were the main efficacy outcomes...
February 8, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29436916/middle-cerebral-artery-pressure-changes-following-pipeline-flow-diversion
#11
Denise Brunozzi, Sophia F Shakur, Fady T Charbel, Ali Alaraj
Objective Pipeline embolization devices (PED) are commonly used for endovascular treatment of cerebral aneurysms but changes in intracranial hemodynamics after PED deployment are poorly understood. Here, we assess middle cerebral artery (MCA) and systemic blood pressure before and after PED treatment. Methods Records of patients with cerebral aneurysms proximal to the internal carotid artery terminus treated with PED at our institution between 2015 and 2017 were retrospectively reviewed. Patients were included if ipsilateral MCA pressure measurements were available...
January 1, 2018: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29436856/chondroitinase-abc-for-neurological-recovery-after-acute-brain-injury-systematic-review-and-meta-analyses-of-preclinical-studies
#12
Chan Hee Koh, Savva Pronin, Mark Hughes
OBJECTIVES: Damage to critical brain regions causes deficits in important neurological functions. Chondroitinase ABC (ChABC) has been shown to promote neuroplasticity and may ameliorate neurological deficits caused by disease or trauma. This systematic review identifies and evaluates preclinical studies of ChABC as a treatment for acute brain injury. METHODS: Four databases were searched for studies relating to ChABC and brain or brain injuries. Controlled studies in mammals with acute brain injuries treated with ChABC were included in meta-analyses of neurobehavioural outcomes...
February 13, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29436736/psychological-stress-induced-cerebrovascular-dysfunction-the-role-of-metabolic-syndrome-and-exercise
#13
Steven Brooks, Kayla Branyan, Evan DeVallance, Roy Skinner, Kent Lemaster, J Whitney Sheets, Christopher R Pitzer, Shinichi Asano, Randall Bryner, I Mark Olfert, Jefferson C Frisbee, Paul D Chantler
Chronic unresolvable stress leads to the development of depression and cardiovascular disease (CVD). There is a high prevalence of depression with the metabolic syndrome (MetS), however, to what extent the MetS concurrent with psychological stress affects cerebrovascular function is unknown. We investigated the differential effect of MetS on cerebrovascular structure/function in rats (16-17-wk-old) following 8 wk of unpredictable chronic mild stress (UCMS), and whether exercise training could limit any cerebrovascular dysfunction...
February 13, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29432753/establishment-of-potent-and-specific-synthetic-substrate-for-dipeptidyl-peptidase-7
#14
Takayuki K Nemoto, Toshio Ono, Yuko Ohara-Nemoto
Bacterial dipeptidyl-peptidase (DPP) 7 liberates a dipeptide with a preference for aliphatic and aromatic penultimate residues from the N-terminus. Although synthetic substrates are useful for activity measurements, those currently used are problematic, because they are more efficiently degraded by DPP5. We here aimed to develop a potent and specific substrate and found that the kcat/Km value for Phe-Met-methylcoumaryl-7-amide (MCA) (41.40 ± 0.83 μM-1 s-1) was highest compared to Met-Leu-, Leu-Leu-, and Phe-Leu-MCA (1...
February 9, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29426978/impact-of-intracranial-artery-calcification-on-cerebral-hemodynamic-changes
#15
Xiaohong Wu, Li Wang, Jingxin Zhong, Jacky Ko, Lin Shi, Yannie Soo, Thomas Leung, Ka Sing Wong, Jill Abrigo, Xiangyan Chen
PURPOSE: Intracranial artery calcification (IAC) has been demonstrated to be correlated with ischemic stroke, cognitive decline, and other vascular events by accumulating evidences from both Western and Asian populations. The proposed study aimed to investigate its potential mechanisms by evaluating the blood flow velocity and pulsatility index (PI) of cerebral arteries. METHODS: Consecutive ischemic stroke patients admitted to the Prince of Wales Hospital were recruited after excluding those with atrial fibrillation or poor temporal window...
February 9, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29424126/fewer-peripheral-asymmetrical-cortical-veins-is-a-predictor-of-favorable-outcome-in-mca-infarctions-with-swi-dwi-mismatch
#16
Tao Yuan, Guoli Ren, Guanmin Quan, Duo Gao
BACKGROUND: Outcome prediction of asymmetrical prominent cortical veins (APCVs) on infarction is still debated and may help in selecting patients for reperfusion treatment. PURPOSE: To explore the relationship between fewer peripheral APCVs and the outcome in the patients of acute/subacute middle cerebral artery (MCA) infarctions as well as the relationship between this sign and stenosis of ipsilateral MCA. STUDY TYPE: Retrospective case-control study...
February 9, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29424118/ultraearly-assessed-reperfusion-status-after-middle-cerebral-artery-recanalization-predicting-clinical-outcome
#17
P Gölitz, I Muehlen, S T Gerner, F Knossalla, A Doerfler
OBJECTIVES: Mechanical thrombectomy has high evidence in stroke therapy; however, successful recanalization guarantees not a favorable clinical outcome. We aimed to quantitatively assess the reperfusion status ultraearly after successful middle cerebral artery (MCA) recanalization to identify flow parameters that potentially allow predicting clinical outcome. MATERIALS AND METHODS: Sixty-seven stroke patients with acute MCA occlusion, undergoing recanalization, were enrolled...
February 8, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29423081/pm2-5-inhalation-induces-intracranial-atherosclerosis-which-may-be-ameliorated-by-omega-3-fatty-acids
#18
Longfei Guan, Xiaokun Geng, Jiamei Shen, James Yip, Fengwu Li, Huishan Du, Zhili Ji, Yuchuan Ding
Background: Intracranial atherosclerosis (ICA) a major health problem. This study investigated whether inhalation of fine airborne particulate matters (PM2.5) causes ICA and whether omega-3 fatty acids (O3FA) attenuated the development of ICA. Results: Twelve but not 6 week exposure significantly increased triglycerides (TG) in normal chow diet (NCD), while PM2.5 enhanced all lipid profiles (TG, low density lipoprotein (LDL) and cholesterol (CHO)) after both 6 and 12-week exposure with high-cholesterol diet (HCD)...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29422868/relationship-between-aortic-compliance-and-impact-of-cerebral-blood-flow-fluctuation-to-dynamic-orthostatic-challenge-in-endurance-athletes
#19
Tsubasa Tomoto, Tomoko Imai, Shigehiko Ogoh, Seiji Maeda, Jun Sugawara
Aorta effectively buffers cardiac pulsatile fluctuation generated from the left ventricular (LV) which could be a mechanical force to high blood flow and low-resistance end-organs such as the brain. A dynamic orthostatic challenge may evoke substantial cardiac pulsatile fluctuation via the transient increases in venous return and stroke volume (SV). Particularly, this response may be greater in endurance-trained athletes (ET) who exhibit LV eccentric remodeling. The aim of this study was to determine the contribution of aortic compliance to the response of cerebral blood flow fluctuation to dynamic orthostatic challenge in ET and age-matched sedentary (SED) young healthy men...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29420157/dynamic-cerebral-autoregulation-during-cognitive-task-effect-of-hypoxia
#20
Shigehiko Ogoh, Hiroki Nakata, Tadayoshi Miyamoto, Damian M Bailey, Manabu Shibasaki
Changes in cerebral blood flow (CBF) subsequent to alterations in the partial pressures of oxygen and carbon dioxide can modify dynamic cerebral autoregulation (CA). While cognitive activity increases CBF, to what extent it impacts CA remains to be established. In the present study we determined if dynamic CA would decrease during a cognitive task and whether hypoxia would further compound impairment. Fourteen young healthy subjects performed a simple Go/No-go task during normoxia and hypoxia (FIO2 =12%) and the corresponding relationship between mean arterial pressure (MAP) and mean middle cerebral artery blood velocity (MCA Vmean) was examined...
February 8, 2018: Journal of Applied Physiology
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