Andrea Da Fonseca Ferreira, Jianqin Wei, Lukun Zhang, Conrad J Macon, Bernard Degnan, Dushyantha Jayaweera, Joshua M Hare, Michael A Kolber, Michael Bellio, Aisha Khan, Yue Pan, Derek M Dykxhoorn, Liyong Wang, Chunming Dong
People living with HIV (PLHIV) are at a higher risk of having cerebrocardiovascular diseases (CVD) compared to HIV negative (HIVneg ) individuals. The mechanisms underlying this elevated risk remains elusive. We hypothesize that HIV infection results in modified microRNA (miR) content in plasma extracellular vesicles (EVs), which modulates the functionality of vascular repairing cells, i.e., endothelial colony-forming cells (ECFCs) in humans or lineage negative bone marrow cells (lin- BMCs) in mice, and vascular wall cells...
April 20, 2023: International Journal of Molecular Sciences