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https://www.readbyqxmd.com/read/29431541/an-update-on-the-use-of-raman-spectroscopy-in-molecular-cancer-diagnostics-current-challenges-and-further-prospects
#1
E Upchurch, M Isabelle, Gavin Rhys Lloyd, C Kendall, H Barr
Introduction Cancer is responsible for an extraordinary burden of disease, affecting 90.5 million people worldwide in 2015. Outcomes for these patients are improved when the disease is diagnosed at an early, or even precancerous, stage. Raman spectroscopy is demonstrating results that show its ability to detect the molecular changes that are diagnostic of precancerous and cancerous tissue. This review highlights the new advances occurring in this domain. Areas Covered PubMed searches were undertaken to identify new research in the utilisation of Raman spectroscopy in cancer diagnostics...
February 12, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29410533/diagnosis-biomarkers-and-balloons-for-the-detection-of-barrett-oesophagus
#2
Katrina Ray
No abstract text is available yet for this article.
February 7, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29314176/improved-diagnostic-stratification-of-digitised-barrett-s-oesophagus-biopsies-by-tp53-immunohistochemical-staining
#3
M J van der Wel, L C Duits, R E Pouw, C A Seldenrijk, G J A Offerhaus, M Visser, F J Ten Kate, K Biermann, L A A Brosens, M Doukas, C Huysentruyt, A Karrenbeld, G Kats-Ugurlu, J S van der Laan, G van Lijnschoten, F C P Moll, A H A G Ooms, H van der Valk, J G Tijssen, J J Bergman, S L Meijer
AIMS: Interobserver agreement for dysplasia in Barrett's oesophagus (BO) is low and guidelines advise expert review of dysplastic cases. We assessed the added value of p53 immunohistochemistry (IHC) on the homogeneity within a group of dedicated gastro-intestinal (GI) pathologists. METHODS AND RESULTS: Sixty single hematoxylin & eosin (HE) slide referral BO cases (20 low-grade dysplasia (LGD); 20 high-grade dysplasia (HGD) and 20 non-dysplastic BO (NDBO) reference cases) were digitalised and independently assessed twice in a random order by 10 dedicated GI pathologists...
January 3, 2018: Histopathology
https://www.readbyqxmd.com/read/29305432/a-case-of-sigmoid-volvulus
#4
Aikaterini Leventi, Thomas Frederick James Clifford, Amy Arnold, Charles H Knowles, Joanne E Martin
CLINICAL PRESENTATION: A 53-year-old man was admitted with a 2-week history of bowel obstruction on a background of gradually worsening dyspeptic symptoms associated with vomiting and weight loss. He was under regular gastroenterology review for Barrett's oesophagus and had a recent endoscopic diagnosis of megaduodenum (mainly D1 dilatation) confirmed by barium study (figure 1). He was also known to have bladder emptying problems and an enlarged bladder. His mother died at age 28 due to 'megacolon', and he has a monozygotic twin brother with Barrett's oesophagus...
January 5, 2018: Gut
https://www.readbyqxmd.com/read/29195669/tobacco-smoking-alcohol-consumption-and-gastro-oesophageal-reflux-disease
#5
REVIEW
Eivind Ness-Jensen, Jesper Lagergren
Gastro-oesophageal reflux disease (GORD) develops when reflux of gastric content causes troublesome symptoms or complications. The main symptoms are heartburn and acid regurgitation and complications include oesophagitis, strictures, Barrett's oesophagus and oesophageal adenocarcinoma. In addition to hereditary influence, GORD is associated with lifestyle factors, mainly obesity. Tobacco smoking is regarded as an aetiological factor of GORD, while alcohol consumption is considered a triggering factor of reflux episodes and not a causal factor...
October 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29184186/oesophagus-a-new-candidate-for-the-progenitor-cell-of-barrett-metaplasia
#6
Rhonda F Souza, Stuart J Spechler
No abstract text is available yet for this article.
November 29, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29177063/circulating-micrornas-as-potential-biomarkers-to-detect-transformation-of-barrett-s-oesophagus-to-oesophageal-adenocarcinoma
#7
Juntaro Matsuzaki, Hidekazu Suzuki
Objective: Circulating microRNAs (miRNAs) are promising biomarkers for the early detection of cancers. This study aimed to address potential circulating miRNAs to monitor the progression from Barrett's oesophagus (BO) to oesophageal adenocarcinoma (OAC). Design: We comprehensively analysed tissue and serum miRNA expression profiles of BO mice model (L2-interleukin-1β (IL-1β) mice) using microarray analysis. To validate the data from mice, a published dataset of human plasma miRNAs, consisting of eight patients with OAC, eight with BO and six healthy controls, was used (GSE51410)...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29161901/long-term-outcomes-of-the-randomized-controlled-trial-comparing-5-aminolaevulinic-acid-and-photofrin-photodynamic-therapy-for-barrett-s-oesophagus-related-neoplasia
#8
Darina Kohoutova, Rehan Haidry, Matthew Banks, Mohammed Adil Butt, Jason Dunn, Sally Thorpe, Laurence Lovat
OBJECTIVE: Photodynamic therapy (PDT) was used as therapy for early neoplasia associated with Barrett's oesophagus (BE). This is 5-year follow-up of patients enrolled into randomised controlled trial of 5-aminolaevulinic acid (ALA) vs. Photofrin PDT. METHODS: Biopsies were taken from original Barrett's segment during endoscopic follow up using Seattle protocol. Endoscopic mucosal resection (EMR) ± radiofrequency ablation (RFA) was preferred therapy in patients who failed PDT and/or had recurrent neoplasia...
November 21, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29097867/dysphagia-thinking-outside-the-box
#9
REVIEW
Hamish Philpott, Mayur Garg, Dunya Tomic, Smrithya Balasubramanian, Rami Sweis
Dysphagia is a common symptom that is important to recognise and appropriately manage, given that causes include life threatening oesophageal neoplasia, oropharyngeal dysfunction, the risk of aspiration, as well as chronic disabling gastroesophageal reflux (GORD). The predominant causes of dysphagia varies between cohorts depending on the interplay between genetic predisposition and environmental risk factors, and is changing with time. Currently in white Caucasian societies adopting a western lifestyle, obesity is common and thus associated gastroesophageal reflux disease is increasingly diagnosed...
October 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29067155/the-2015-upper-gastrointestinal-be-clear-on-cancer-campaign-its-impact-on-gastroenterology-services-and-malignant-and-premalignant-diagnoses
#10
Keith Siau, Andrew Chong Yew, Samantha Hingley, James Rees, Nigel John Trudgill, Andrew M Veitch, Neil C Fisher
OBJECTIVE: To assess the impact of the upper gastrointestinal 'Be Clear on Cancer' campaign launched by Public Health England between January and February 2015 on open-access gastroscopy referrals, incidence of target diagnoses (oesophagogastric cancer and Barrett's oesophagus), cancer staging at presentation, 1-year survival and cost per additional diagnosis. DESIGN: We performed a retrospective study of patients referred for 2-week-wait (2WW), open-access endoscopy 3 months following the campaign with diagnoses, endoscopic findings, staging and 12-month survival compared with data from corresponding months in 2014...
October 2017: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29064850/the-association-between-physical-activity-and-the-risk-of-symptomatic-barrett-s-oesophagus-a-uk-prospective-cohort-study
#11
Stephen Lam, Leo Alexandre, Robert Luben, Andrew R Hart
BACKGROUND: Physical activity affects the functioning of the gastrointestinal system through both local and systemic effects and may play an important role in the aetiology of gastroesophageal reflux disease, Barrett's oesophagus and oesophageal adenocarcinoma. We investigated, for the first time in a large prospective cohort study, associations between recreational and occupational levels of physical activity and the incidence of Barrett's oesophagus. PARTICIPANTS AND METHODS: The European Prospective Investigation of Cancer-Norfolk recruited 30 445 men and women between 1993 and 1997...
October 23, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29059206/use-of-immunohistochemical-biomarkers-as-independent-predictor-of-neoplastic-progression-in-barrett-s-oesophagus-surveillance-a-systematic-review-and-meta-analysis
#12
REVIEW
Vincent T Janmaat, Sophie H van Olphen, Katharina E Biermann, Leendert H J Looijenga, Marco B Bruno, Manon C W Spaander
INTRODUCTION: The low incidence of oesophageal adenocarcinoma (EAC) in Barrett's oesophagus (BE) patients reinforces the need for risk stratification tools to make BE surveillance more effective. Therefore, we have undertaken a systematic review and meta-analysis of published studies on immunohistochemical (IHC) biomarkers in BE to determine the value of IHC biomarkers as neoplastic predictors in BE surveillance. MATERIALS AND METHODS: We searched MEDLINE, EMBASE, Web of Science, CENTRAL, Pubmed publisher, and Google scholar...
2017: PloS One
https://www.readbyqxmd.com/read/29021249/prescribing-ppis
#13
(no author information available yet)
Proton pump inhibitors (PPIs) are widely prescribed and many people remain on them for years. In some, there may be good justification for long-term use; for example, in those with oesophageal stricture, Barrett's oesophagus or a history of a bleeding gastrointestinal ulcer, or to provide gastroprotection in those at high risk of gastrointestinal complications from taking NSAIDs. However, PPIs are often not used in line with clinical guidelines.1,2 In addition, there are concerns that many people take them for long periods to manage less serious conditions (e...
October 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/29019984/transitional-basal-cells-at-the-squamous-columnar-junction-generate-barrett-s-oesophagus
#14
Ming Jiang, Haiyan Li, Yongchun Zhang, Ying Yang, Rong Lu, Kuancan Liu, Sijie Lin, Xiaopeng Lan, Haikun Wang, Han Wu, Jian Zhu, Zhongren Zhou, Jianming Xu, Dong-Kee Lee, Lanjing Zhang, Yuan-Cho Lee, Jingsong Yuan, Julian A Abrams, Timothy C Wang, Antonia R Sepulveda, Qi Wu, Huaiyong Chen, Xin Sun, Junjun She, Xiaoxin Chen, Jianwen Que
In several organ systems, the transitional zone between different types of epithelium is a hotspot for pre-neoplastic metaplasia and malignancy, but the cells of origin for these metaplastic epithelia and subsequent malignancies remain unknown. In the case of Barrett's oesophagus, intestinal metaplasia occurs at the gastro-oesophageal junction, where stratified squamous epithelium transitions into simple columnar cells. On the basis of a number of experimental models, several alternative cell types have been proposed as the source of this metaplasia but in all cases the evidence is inconclusive: no model completely mimics Barrett's oesophagus in terms of the presence of intestinal goblet cells...
October 26, 2017: Nature
https://www.readbyqxmd.com/read/28980899/oesophageal-disease-in-systemic-sclerosis-does-heritability-play-a-role
#15
Tracy Frech, Latifa Fakoya, Andrew J Gawron, Jathine Wong, Mary Beth Scholand, Allen Sawitzke, Kathryn Peterson
OBJECTIVES: In systemic sclerosis (SSc) the most common gastrointestinal tract (GIT) complaint is gastroesophageal reflux disease (GERD), which may contribute to oesophagitis, stricture, Barrett's oesophagus, and oesophageal adenocarcinoma. We used a genealogical resource the Utah Population Database (UPDB) to analyse SSc pedigrees for hereditability of oesophageal disease. METHODS: SSc, GERD, oesophagitis, stricture, Barrett's, and oesophageal adenocarcinoma were defined by ICD Ninth and Tenth Revision codes...
October 2, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28980336/incidence-and-predictors-of-osteoporotic-fractures-in-patients-with-barrett-s-oesophagus-a-population-based-nested-case-control-study
#16
S Kumar, M T Drake, C D Schleck, M L Johnson, J A Alexander, D A Katzka, P G Iyer
BACKGROUND: Proton pump inhibitors (PPI) are inconsistently associated with osteoporotic fractures. Barrett's oesophagus (BO) patients are treated with high PPI doses for prolonged periods, but there are limited data on the incidence of osteoporosis and fractures in this group pf patients. AIM: To estimate the incidence of (and risk factors for) low bone mass (osteoporosis and/or osteopenia) related fractures in a population-based BO cohort. METHODS: All subjects with BO and a diagnosis of osteoporosis and fractures were identified using Rochester Epidemiology Project resources...
December 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28970288/international-development-and-validation-of-a-classification-system-for-the-identification-of-barrett-s-neoplasia-using-acetic-acid-chromoendoscopy-the-portsmouth-acetic-acid-classification-predict
#17
Kesavan Kandiah, Fergus J Q Chedgy, Sharmila Subramaniam, Gaius Longcroft-Wheaton, Paul Bassett, Alessandro Repici, Prateek Sharma, Oliver Pech, Pradeep Bhandari
BACKGROUND: Barrett's oesophagus is an established risk factor for developing oesophageal adenocarcinoma. However, Barrett's neoplasia can be subtle and difficult to identify. Acetic acid chromoendoscopy (AAC) is a simple technique that has been demonstrated to highlight neoplastic areas but lesion recognition with AAC remains a challenge, thereby hampering its widespread use. OBJECTIVE: To develop and validate a simple classification system to identify Barrett's neoplasia using AAC...
September 28, 2017: Gut
https://www.readbyqxmd.com/read/28970029/effect-of-diagnosis-surveillance-and-treatment-of-barrett-s-oesophagus-on-health-related-quality-of-life
#18
REVIEW
James Britton, Richard Keld, Neeraj Prasad, Shaheen Hamdy, John McLaughlin, Yeng Ang
Barrett's oesophagus is a chronic precancerous condition that predisposes patients to the development of oesophageal adenocarcinoma, which, once invasive, carries a poor prognosis. This likelihood of a negative outcome has led to the development of robust surveillance and treatment pathways. The true effect of Barrett's oesophagus on life expectancy and the efficacy of long-term surveillance remains under debate. With these uncertainties and no reliable methods of individual risk stratification, patients must be continually monitored and thus carry the burden of this chronic disease...
September 29, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28941013/deoxycholic-acid-promotes-development-of-gastroesophageal-reflux-disease-and-barrett-s-oesophagus-by-modulating-integrin-%C3%AE-v-trafficking
#19
David O Prichard, Anne Marie Byrne, James O Murphy, John V Reynolds, Jacintha O'Sullivan, Ronan Feighery, Brendan Doyle, Osama Sharaf Eldin, Stephen P Finn, Aoife Maguire, Deirdre Duff, Dermot P Kelleher, Aideen Long
The fundamental mechanisms underlying erosive oesophagitis and subsequent development of Barrett's oesophagus (BO) are poorly understood. Here, we investigated the contribution of specific components of the gastric refluxate on adhesion molecules involved in epithelial barrier maintenance. Cell line models of squamous epithelium (HET-1A) and BO (QH) were used to examine the effects of bile acids on cell adhesion to extracellular matrix proteins (Collagen, laminin, vitronectin, fibronectin) and expression of integrin ligands (α3 , α4, α5 , α6 and αν )...
September 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28867477/research-priority-setting-in-barrett-s-oesophagus-and-gastro-oesophageal-reflux-disease
#20
James Britton, Lisa Gadeke, Laurence Lovat, Shaheen Hamdy, Chris Hawkey, John McLaughlin, Yeng Ang
The incidence of gastro-oesophageal reflux disease and Barrett's oesophagus is increasing. Barrett's oesophagus is the main precursor to oesophageal adenocarcinoma, which has a poor prognosis. In view of the vast potential burden of these diseases on patients and health-care resources, there is a real need to define and focus research efforts. This priority setting exercise aimed to produce a list of the top ten uncertainties in the field that reflect the priorities of patients and health-care providers. We adopted the robust and transparent methodologies previously outlined by the James Lind Alliance...
November 2017: Lancet. Gastroenterology & Hepatology
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