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https://www.readbyqxmd.com/read/28062694/effective-combination-of-innate-and-adaptive-immunotherapeutic-approaches-in-a-mouse-melanoma-model
#1
Alexander L Rakhmilevich, Mildred Felder, Lauren Lever, Jacob Slowinski, Kayla Rasmussen, Anna Hoefges, Tyler J Van De Voort, Hans Loibner, Alan J Korman, Stephen D Gillies, Paul M Sondel
Most cancer immunotherapies include activation of either innate or adaptive immune responses. We hypothesized that the combined activation of both innate and adaptive immunity will result in better antitumor efficacy. We have previously shown the synergy of an agonistic anti-CD40 mAb (anti-CD40) and CpG-oligodeoxynucleotides in activating macrophages to induce tumor cell killing in mice. Separately, we have shown that a direct intratumoral injection of immunocytokine (IC), an anti-GD2 Ab linked to IL-2, can activate T and NK cells resulting in antitumor effects...
January 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28061552/the-role-of-nursing-professionals-in-the-management-of-patients-with-high-risk-neuroblastoma-receiving-dinutuximab-therapy
#2
Rita Secola, Araz Marachelian, Susan L Cohn, Bonnie Toy, Kathleen Neville, Meaghan Granger, Angela Brentlinger, Gina Martin
Neuroblastoma, an embryonic cancer of the sympathetic nervous system, is the most common extracranial solid tumor in childhood. Dinutuximab (formerly called ch14.18), a monoclonal antibody targeting the disialoganglioside GD2, has been shown to significantly improve survival rates in patients with high-risk neuroblastoma. However, the safe and effective use of dinutuximab therapy in these high-risk patients requires medical expertise in patient selection, treatment administration, and the monitoring and management of adverse events...
January 1, 2017: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/28058412/new-metal-chalcogenides-found-in-mnn-1-gd2-xinx-sn-2-n-3-4-5-syntheses-structures-and-magnetic-properties
#3
I C Liang, C Y Weng, C Huang, C K Chang, H S Sheu, J G Lin, K F Hsu
Three new metal chalcogenides have been identified in MnN-1(Gd2-xInx)SN+2 with N = 3, 4, and 5 via a flux-growth synthesis. All compounds crystallize in the same space group of orthorhombic Cmcm with cell constants: Mn2GdInS5 (1), a = 3.789(1) Å, b = 12.411(1) Å, and c = 15.489(1) Å; Mn3Gd2S6 (2), a = 3.778(1) Å, b = 12.505(2) Å, and c = 19.114(2) Å; Mn4Gd2S7 (3), a = 3.769(1) Å, b = 12.466(2) Å, and c = 22.289(3) Å. Compounds 1-3 form a homologous series through the modulation of the MnS unit, whose structures represent a complete system of the corresponding lillianites ((N1,N2)L) of (3,3)L, (4,4)L and (5,5)L...
January 6, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28040394/long-term-hematological-visceral-and-growth-outcomes-in-children-with-gaucher-disease-type-3-treated-with-imiglucerase-in-the-international-collaborative-gaucher-group-gaucher-registry
#4
Amal El-Beshlawy, Anna Tylki-Szymanska, Ashok Vellodi, Nadia Belmatoug, Gregory A Grabowski, Edwin H Kolodny, Julie L Batista, Gerald F Cox, Pramod K Mistry
In Gaucher disease (GD), deficiency of lysosomal acid β-glucosidase results in a broad phenotypic spectrum that is classified into three types based on the absence (type 1 [GD1]) or presence and severity of primary central nervous system involvement (type 2 [GD2], the fulminant neuronopathic form, and type 3 [GD3], the milder chronic neuronopathic form). Enzyme replacement therapy (ERT) with imiglucerase ameliorates and prevents hematological and visceral manifestations in GD1, but data in GD3 are limited to small, single-center series...
December 6, 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27999754/neuroblastoma-patients-with-high-affinity-fcgr2a-3a-and-stimulatory-kir-2ds2-treated-by-long-term-infusion-of-anti-gd2-antibody-ch14-18-cho-show-higher-adcc-levels-and-improved-event-free-survival
#5
Nikolai Siebert, Christian Jensen, Sascha Troschke-Meurer, Maxi Zumpe, Madlen Jüttner, Karoline Ehlert, Silke Kietz, Ina Müller, Holger N Lode
Polymorphisms in Fc-gamma-receptor (FCGR) genes as well as killer cell immunoglobulin-like receptor (KIR) and KIR ligand (KIRL) repertoires may influence antitumor effects of monoclonal antibodies (mAb). Here, we systematically analyzed high- and low-affinity FCGR2A and -3A genotypes as well as stimulating and inhibitory KIR/KIRL combinations in 53 neuroblastoma (NB) patients treated by long-term infusion (LTI) of anti-GD2 IgG1 Ab ch14.18/CHO using validated real-time PCR methods. Patients with high-affinity FCGR2A and -3A genotypes showed a higher level of Ab-dependent cell-mediated cytotoxicity (ADCC) on day 8 after the start of ch14...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27979707/disrupting-domain-domain-interactions-is-indispensable-for-enga-ribosome-interactions
#6
Soneya Majumdar, Abhishek Acharya, Sushil Kumar Tomar, Balaji Prakash
EngA consists of two tandem GTPase-domains-GD1 and GD2-followed by a KH-domain. EngA was considered to be a 50S assembly factor since it was shown to bind 50S and its deletion leads to the accumulation of immature 45S ribosomal subunits. Subsequently, we demonstrated an additional ribosome bound state of EngA bound to 50S, 30S, and 70S. While the former (50S binding) is achieved upon GTP binding at both GD1 and GD2, the latter is formed upon GTP hydrolysis at GD1, which is believed to trigger a large conformational change in the protein...
December 13, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27958647/mass-spectrometric-study-of-thermodynamic-properties-in-the-gd2-o3-y2-o3-system-at-high-temperatures
#7
Eugene N Kablov, Valentina L Stolyarova, Sergey I Lopatin, Viktor A Vorozhtcov, Fedor N Karachevtsev, Yuriy I Folomeikin
RATIONALE: The Gd2 O3 -Y2 O3 system possesses a number of practical applications, one of the most important of them being production of casting molds for the gas turbine engine blades. The components of this system are often added to zirconia or hafnia to obtain high temperature ceramics which are used for development of thermal barrier coatings. However, Gd2 O3 and Y2 O3 are more volatile than zirconia or hafnia and may vaporize selectively during synthesis or usage of high temperature materials which may lead to changes in their physicochemical properties...
December 13, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27956354/maldi-imaging-delineates-hippocampal-glycosphingolipid-changes-associated-with-neurotoxin-induced-proteopathy-following-neonatal-bmaa-exposure
#8
Oskar Karlsson, Wojciech Michno, Yusuf Ransome, Jörg Hanrieder
The environmental toxin β-N-methylamino-L-alanine (BMAA) has been proposed to contribute to neurodegenerative diseases. We have previously shown that neonatal exposure to BMAA results in dose-dependent cognitive impairments, proteomic alterations and progressive neurodegeneration in the hippocampus of adult rats. A high BMAA dose (460mg/kg) also induced intracellular fibril formation, increased protein ubiquitination and enrichment of proteins important for lipid transport and metabolism. The aim of this study was therefore to elucidate the role of neuronal lipids in BMAA-induced neurodegeneration...
December 9, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27922757/hemophagocytic-lymphohistiocytosis-triggered-by-gaucher-disease-in-a-preterm-neonate
#9
Simone Schüller, Andishe Attarbaschi, Angelika Berger, Caroline Hutter, Katrin Klebermass-Schrehof, Manuel Steiner
OBJECTIVE: To present the diagnostic workup in an extremely low birth weight infant patient with signs of both sepsis and hemophagocytosis. PARTICIPANTS: A preterm infant presented with clinical and laboratory signs of early-onset sepsis including hepatosplenomegaly, thrombocytopenia, direct hyperbilirubinemia, and elevated liver enzymes. METHODS: Despite extensive septic workup, no underlying infection was detected. Additional hyperferritinemia and other elevated inflammatory parameters raised the suspicion of a primary or secondary hemophagocytic lymphohistiocytosis (HLH)...
October 2016: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/27911407/preparation-of-cd4-t-cells-for-analysis-of-gd3-and-gd2-ganglioside-membrane-expression-by-microscopy
#10
Tania M Villanueva-Cabello, Iván Martinez-Duncker
The methods described herein for activation of naïve CD4(+) T cells in suspension and their adherence in coverslips for confocal microscopy analysis allow the spatial localization and visualization of gangliosides involved in CD4(+) T cell activation, that complement expression profiling experiments such as flow cytometry, western blotting or real-time PCR. The quantification of ganglioside expression through flow cytometry and their cellular localization through microscopy can be obtained by the use of anti-ganglioside antibodies with high affinity and specificity...
November 8, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27872101/natural-killer-cells-to-the-attack-combination-therapy-against-neuroblastoma
#11
Olatz Zenarruzabeitia, Joana Vitalle, Itziar Astigarraga, Francisco Borrego
Transforming growth factor-beta (TGFβ) in the tumor microenvironment diminishes natural killer (NK) cell-mediated anti-disialoganglioside (anti-GD2) monoclonal antibody (mAb) elimination of neuroblastoma cells. Consequently, blockade of the TGFβ signaling with galunisertib, in combination with anti-GD2 mAb dinutuximab plus adoptively transferred NK cells, is a promising tool for the treatment of neuroblastoma.
November 21, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27830078/-intestinimonas-massiliensis-sp-nov-a-new-bacterium-isolated-from-human-gut
#12
G Durand, P Afouda, D Raoult, G Dubourg
Here we report the main features of the proposed new bacterial species "Intestinimonas massiliensis" sp. nov. The type strain GD2(T) (CSUR = P1930) was isolated from the gut microbiota of a healthy patient using a culturomics approach combined with taxonogenomics.
January 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/27827484/building-1d-lanthanide-chains-and-non-symmetrical-ln2-triple-decker-clusters-using-salen-type-ligands-magnetic-cooling-and-relaxation-phenomena
#13
Angelos B Canaj, Milosz Siczek, Marta Otręba, Tadeusz Lis, Giulia Lorusso, Marco Evangelisti, Constantinos J Milios
A solvothermal reaction between Ln(NO3)3·6H2O (Ln: Gd, Tb and Dy), 2-hydroxy-1-naphthaldehyde, 2-OH-naphth, and ethylenediamine, en, in MeOH in the presence of a base, NEt3, led to the formation of the 1D coordination polymers [Ln(L)(MeO)(MeOH)0.5]n·MeOH (Ln = Gd (1·MeOH), Tb(2), Dy (3·MeOH); H2L = 1,1'-((1E,1'E)-(ethane-1,2-diylbis(azanylylidene))bis(methanylylidene))bis(naphthalen-2-ol), the Schiff-base ligand derived from the condensation of 2-OH-naphth and en), while a similar reaction in an excess of NaN3 yielded 1D coordination polymers [Ln(L)(N3)0...
November 9, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27801447/efficient-charge-transfer-and-utilization-of-near-infrared-solar-spectrum-by-ytterbium-and-thulium-codoped-gadolinium-molybdate-gd2-moo4-3-yb-tm-nanophosphor-in-hybrid-solar-cells
#14
Weifu Sun, Zihan Chen, Qin Zhang, Junli Zhou, Feng Li, Xiao Jin, Dongyu Li, Qinghua Li
In this work, thulium and ytterbium codoped gadolinium molybdate (Gd2(MoO4)3:Yb/Tm) nanophosphors (NPs) have been synthesized, followed by being incorporated into a photo-catalytic titania (TiO2) nanoparticle layer. In detail, morphology and phase identification of the prepared NPs are first characterized and then the up-conversion of the Gd2(MoO4)3:Yb/Tm NPs is studied. Electron transfer dynamics after interfacing with bare or NP-doped electron donor TiO2 and the corresponding photovoltaic performance of solar cells are explored...
November 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27787537/minimal-disseminated-disease-in-nonmetastatic-retinoblastoma-with-high-risk-pathologic-features-and-association-with-disease-free-survival
#15
Viviana E Laurent, Ana Vanesa Torbidoni, Claudia Sampor, Daniela Ottaviani, Valeria Vazquez, Mariano R Gabri, Maria Teresa Garcia de Davila, Marco A Ramirez-Ortiz, Cristina Noemi Alonso, Jorge Rossi, Daniel F Alonso, Guillermo L Chantada
Importance: Fatal metastatic relapse may occur in children with retinoblastoma and high-risk pathologic features (HRPFs). Minimal dissemination (MD) may be an additional tool for risk estimation. The use of cone-rod homeobox (CRX) transcription factor messenger RNA for MD evaluation in metastatic retinoblastoma was previously reported, but no data in nonmetastatic cases with HRPFs are available. Objectives: To evaluate whether MD is detectable in patients with nonmetastatic retinoblastoma and to assess its prognostic effect on disease-free survival (DFS)...
December 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27756784/tgf%C3%AE-r1-blockade-with-galunisertib-ly2157299-enhances-anti-neuroblastoma-activity-of-anti-gd2-antibody-dinutuximab-ch14-18-with-natural-killer-cells
#16
Hung C Tran, Zesheng Wan, Michael A Sheard, Jianping Sun, Jeremy R Jackson, Jemily Malvar, Yibing Xu, Larry Wang, Richard Sposto, Eugene S Kim, Shahab Asgharzadeh, Robert C Seeger
PURPOSE: Immunotherapy of high-risk neuroblastoma using the anti-GD2 antibody dinutuximab induces antibody-dependent cell-mediated cytotoxicity (ADCC). Galunisertib, an inhibitor of TGFβR1, was examined for its ability to enhance the efficacy of dinutuximab in combination with human ex vivo activated NK (aNK) cells against neuroblastoma. EXPERIMENTAL DESIGN: TGFB1 and TGFBR1 mRNA expression was determined for 249 primary neuroblastoma tumors by microarray analysis...
October 10, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27726347/influence-of-tuned-linker-functionality-on-modulation-of-magnetic-properties-and-relaxation-dynamics-in-a-family-of-six-isotypic-ln2-ln-dy-and-gd-complexes
#17
Soumya Mukherjee, Jingjing Lu, Gunasekaran Velmurugan, Shweta Singh, Gopalan Rajaraman, Jinkui Tang, Sujit K Ghosh
A coordination complex family comprising of six new dinuclear symmetric lanthanide complexes, namely, [Ln2(Lx)2(L')2(CH3OH)2]·yG (H2Lx: three related yet distinct Schiff-base linkers; x = 1-3, according to the nomenclature of the Schiff-base linker employed herein. HL': 2,6-dimethoxyphenol. yG refers to crystallographically assigned guest solvent species in the respective complexes; y = number of solvent molecules; Ln(III) = Dy/Gd) were isolated employing a mixed-ligand strategy stemming out of a strategic variation of the functionalities introduced among the constituent Schiff-base linkers...
November 7, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27716850/efficient-killing-of-high-risk-neuroblastoma-using-natural-killer-cells-activated-by-plasmacytoid-dendritic-cells
#18
Martine Cordeau, Assila Belounis, Martin Lelaidier, Paulo Cordeiro, Hervé Sartelet, Sabine Herblot, Michel Duval
High-risk neuroblastoma (NB) remains a major therapeutic challenge despite the recent advent of disialoganglioside (GD2)-antibody treatment combined with interleukin (IL)-2 and granulocyte monocyte-colony stimulating factor (GM-CSF). Indeed, more than one third of the patients still die from this disease. Here, we developed a novel approach to improve the current anti-GD2 immunotherapy based on NK cell stimulation using toll-like receptor (TLR)-activated plasmacytoid dendritic cells (pDCs). We demonstrated that this strategy led to the efficient killing of NB cells...
2016: PloS One
https://www.readbyqxmd.com/read/27716771/identification-and-tumour-binding-properties-of-a-peptide-with-high-affinity-to-the-disialoganglioside-gd2
#19
Jan Müller, Robin Reichel, Sebastian Vogt, Stefan P Müller, Wolfgang Sauerwein, Wolfgang Brandau, Angelika Eggert, Alexander Schramm
Neuroectodermal tumours are characterized by aberrant processing of disialogangliosides concomitant with high expression of GD2 or GD3 on cell surfaces. Antibodies targeting GD2 are already in clinical use for therapy of neuroblastoma, a solid tumour of early childhood. Here, we set out to identify peptides with high affinity to human disialoganglioside GD2. To this end, we performed a combined in vivo and in vitro screen using a recombinant phage displayed peptide library. We isolated a phage displaying the peptide sequence WHWRLPS that specifically binds to the human disialoganglioside GD2...
2016: PloS One
https://www.readbyqxmd.com/read/27708204/evidence-for-the-efficacy-of-immunotherapy-in-children-with-high-risk-neuroblastoma
#20
Elwira Szychot, Jarosław Peregud-Pogorzelski, Paweł Wawryków, Andrzej Brodkiewicz
Neuroblastoma is the most common extra-cranial malignancy of childhood, with the highest incidence in children younger than 4 years. The prognosis depends on many factors, such as age at diagnosis, stage of disease and molecular genetic subtype. More than 50% of children who present with the disease are deemed to have high-risk neuroblastoma. The standard therapy for children with high-risk neuroblastoma consists of intensive chemotherapy, surgery, radiotherapy, myeloablative consolidation with autologous haematopoietic stem cell rescue followed by the treatment of minimal residual disease with 13-cis-retinoic acid...
September 28, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
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