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https://www.readbyqxmd.com/read/29151270/asct2-defined-by-enzyme-mediated-activation-of-radical-sources-enhances-malignancy-of-gd2-plus-small-cell-lung-cancer
#1
Nobutoshi Esaki, Yuki Ohkawa, Noboru Hashimoto, Yuhsuke Tsuda, Yuhsuke Ohmi, Robiul H Bhuiyan, Norihiro Kotani, Koichi Honke, Atsushi Enomoto, Masahide Takahashi, Keiko Furukawa, Koichi Furukawa
Ganglioside GD2 is specifically expressed in small cell lung cancer (SCLC) cells, leading to enhancement of malignant phenotypes, such as cell proliferation and migration. However, how GD2 promotes malignant phenotypes in SCLC cells is not well known. In this study, to reveal mechanisms by which GD2 increases malignant phenotypes in SCLC cells, we performed enzyme-mediated activation of radical sources combined with mass spectrometry in GD2 positive (+) SCLC cells. Consequently, we identified ASC amino-acid transporter 2 (ASCT2), a major glutamine transporter, which coordinately works with GD2...
November 19, 2017: Cancer Science
https://www.readbyqxmd.com/read/29147617/phase-i-trial-of-anti-gd2-monoclonal-antibody-hu3f8-plus-gm-csf-impact-of-body-weight-immunogenicity-and-anti-gd2-response-on-pharmacokinetics-and-survival
#2
Irene Y Cheung, Brian H Kushner, Shakeel Modak, Ellen M Basu, Stephen S Roberts, Nai-Kong V Cheung
Fifty-seven stage 4 patients with refractory/relapsed neuroblastoma were enrolled in a phase I trial (Clinicaltrials.gov NCT01757626) using humanized anti-GD2 monoclonal antibody hu3F8 in combination with granulocyte-macrophage colony-stimulating factor. The influence of body weight and human anti-human antibody (HAHA) on the pharmacokinetics (PK) of hu3F8, and the effect of de novo anti-GD2 response on patient outcome were explored. Serum samples before hu3F8 infusion, and serially up to day 12 during treatment cycle #1, and at 5 min after each hu3F8 infusion for all subsequent cycles were collected...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29139510/crystal-structures-and-magnetic-properties-of-two-series-of-phenoxo-o-bridged-dinuclear-ln2-ln-gd-tb-dy-complexes
#3
Marek Machata, Radovan Herchel, Ivan Nemec, Zdeněk Trávníček
Six dinuclear lanthanide compounds of the formulae [Ln2(3m-L4)2(L2)2(MeOH)2]·6MeOH (Ln = Gd - 1a, Tb - 1b, and Dy - 1c) and [Ln2(3m-L4)2(L2)2(DMF)2] (Ln = Gd - 2a, Tb - 2b, and Dy - 2c; DMF = N,N-dimethylformamide, H23m-L4 = (2-[(E)-(3-metoxysalicylidene)amino]phenol), and HL2 = 1,3-diphenyl-1,3-diketopropane) were prepared and characterized by elemental analysis, FTIR spectroscopy, thermogravimetric measurements, single-crystal X-ray structural analysis, and magnetometry, and Gd2 and Dy2 compounds by ab initio methods as well...
November 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29132473/-progress-in-clinical-studies-of-chimeric-antigen-receptor-engineered-t-cells-for-treatment-of-childhood-cancer
#4
Ya-Ru Ni, Xiao-Jun Xu, Yong-Min Tang
Nowadays, the 5-year survival rate of childhood cancer patients can be more than 80%, but some patients with relapse and refractory cancers have shown no good response to traditional strategies. Chimeric antigen receptor engineered T (CAR-T) cell therapy is promising for these patients. CAR-T cells recognize the tumor-associated antigens in a non-major histocompatibility complex-restricted manner, so their anti-tumor ability is enhanced. There are four generations of CAR-T cells now. The complete remission rate of pediatric patients with relapse and refractory acute lymphoblastic leukemia can be as high as 90% when treated with CD19-targeting CAR-T cells...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29123953/pd-1-blockade-augments-anti-neuroblastoma-immune-response-induced-by-anti-gd2-antibody-ch14-18-cho
#5
Nikolai Siebert, Maxi Zumpe, Madlen Jüttner, Sascha Troschke-Meurer, Holger N Lode
Immunotherapy with anti-GD2 antibody (Ab) ch14.18/CHO is effective for treatment of high-risk neuroblastoma (NB) patients and is mainly based on GD2-specific Ab-dependent cellular cytotoxicity (ADCC). Strategies to further enhance the efficacy are important and currently explored in prospective clinical trials randomizing ch14.18/CHO ± IL-2. Recently, expression of programmed death 1 (PD-1) inhibitory receptor by effector cells and its ligand (PD-L1) by tumor cells has been shown. Here, we report for the first time effects of PD-1 blockade on ch14...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29120699/tolerability-response-and-outcome-of-high-risk-neuroblastoma-patients-treated-with-long-term-infusion-of-anti-gd2-antibody-ch14-18-cho
#6
Ina Mueller, Karoline Ehlert, Stefanie Endres, Lena Pill, Nikolai Siebert, Silke Kietz, Penelope Brock, Alberto Garaventa, Dominique Valteau-Couanet, Evelyne Janzek, Norbert Hosten, Andreas Zinke, Winfried Barthlen, Emine Varol, Hans Loibner, Ruth Ladenstein, Holger N Lode
Immunotherapy with short term infusion (STI) of monoclonal anti-GD2 antibody (mAb) ch14.18 (4 × 25mg/m(2)/d; 8-20h) in combination with cytokines and 13-cis retinoic acid (RA) prolonged survival in high-risk neuroblastoma (NB) patients. Here, we investigated long-term infusion (LTI) of ch14.18 produced in Chinese hamster ovary cells (ch14.18/CHO; 10 × 10mg/m(2); 24h) in combination with subcutaneous (s.c.) interleukin-2 (IL-2) in a single center program and report clinical response, toxicity and survival...
November 9, 2017: MAbs
https://www.readbyqxmd.com/read/29111524/cs3lizn2-wo4-4-and-rb3li2ga-moo4-4-different-filled-derivatives-of-the-cation-deficient-cs6zn5-moo4-8-structure
#7
Sergey F Solodovnikov, Zoya A Solodovnikova, Evgeniya S Zolotova, Yulia M Kadyrova, Aleksandra A Savina, Sergey Yu Stefanovich, Elena G Khaikina
Two new compounds, namely cubic tricaesium lithium dizinc tetrakis(tetraoxotungstate), Cs3LiZn2(WO4)4, and tetragonal trirubidium dilithium gallium tetrakis(tetraoxomolybdate), Rb3Li2Ga(MoO4)4, belong to the structural family of Cs6Zn5(MoO4)8 (space group I-43d, Z = 4), with a partially incomplete (Zn5/6□1/6) position. In Cs3LiZn2(WO4)4, this position is fully statistically occupied by (Zn2/3Li1/3), and in Rb3Li2Ga(MoO4)4, the 2Li + Ga atoms are completely ordered in two distinct sites of the space group I-42d (Z = 4)...
November 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29090915/synthesis-of-ce2o2s-and-gd2-1-y-ce2yo2s-nanoparticles-and-reactivity-from-in-situ-x-ray-absorption-spectroscopy-and-x-ray-photoelectron-spectroscopy
#8
Clément Larquet, Anh-Minh Nguyen, Mario Ávila-Gutiérrez, Lionel Tinat, Benedikt Lassalle-Kaiser, Jean-Jacques Gallet, Fabrice Bournel, Andrea Gauzzi, Clément Sanchez, Sophie Carenco
Lanthanide oxysulfide nanoparticles have recently attracted interest in view of their potential applications, such as lighting devices and MRI contrast agents, which requires a good stability in air and a controlled surface. In order to address these issues, in this work, air-sensitive Ce2O2S nanoparticles of hexagonal shape were successfully prepared and characterized under inert conditions. Bimetallic Gd2(1-y)Ce2yO2S nanoparticles of similar shape and size were also synthesized for the whole composition range (y from 0 to 1)...
November 1, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29073719/value-of-whole-breast-magnetic-resonance-elastography-added-to-mri-for-lesion-characterization
#9
Corinne Balleyguier, Aicha Ben Lakhdar, Ariane Dunant, Marie-Christine Mathieu, Suzette Delaloge, Ralph Sinkus
The purpose of this work was to assess the diagnostic value of magnetic resonance elastography (MRE) in addition to MRI to differentiate malignant from benign breast tumors, and the feasibility of performing MRE on the whole breast. MRE quantified biomechanical properties within the entire breast (50 slices) using an 11 min acquisition protocol at an isotropic image acquisition resolution of 2 × 2 × 2 mm(3) . Fifty patients were included. Finally, 43 patients (median age 52) with a suspect breast lesion detected by mammography and/or ultrasound were examined by MRI and MRE at 1...
October 26, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29067879/expression-of-disialoganglioside-gd2-in-neuroblastic-tumors-a-prognostic-value-for-patients-treated-with-anti-gd2-immunotherapy
#10
Tatjana Terzic, Martine Cordeau, Sabine Herblot, Pierre Teira, Sonia Cournoyer, Mona Beaunoyer, Michel Peuchmaur, Michel Duval, Herve Sartelet
Neuroblastoma, a malignant neoplasm of the sympathetic nervous system, is one of the most aggressive pediatric cancers. Patients with stage IV high-risk neuroblastoma receive an intensive multimodal therapy ending with an immunotherapy based on a chimeric monoclonal antibody ch14.18. Although the use of ch14.18 monoclonal antibody has significantly increased the survival rate of high-risk neuroblastoma patients, about 33% of these patients still relapse and die from their disease. Ch14.18 targets the disialoganglioside, GD2, expressed on neuroblastic tumor (NT) cells...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28976578/portal-mv-imaging-with-thin-film-high-energy-current-x-ray-detectors-a-monte-carlo-study
#11
Bo Liu, Piotr Zygmanski, Erno Sajo
PURPOSE: We investigate the potential of the recently introduced high-energy current (HEC) thin-film detector as an alternative design to existing electronic portal imaging devices (EPID). The HEC radiation detectors employ multiple nano-/micrometer layers made of disparate atomic number (Z) conductors separated by solid or gaseous (e.g., air) dielectrics. The HEC detector may be designed as an external structure or an auxiliary device integrated into the existing EPID. METHOD: Using Geant4 Monte Carlo simulations, we compare the image contrast of a HEC detector to that of a commercial EPID device (AS500) for a 2...
October 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28972044/neuroblastoma-patients-kir-and-kir-ligand-genotypes-influence-clinical-outcome-for-dinutuximab-based-immunotherapy-a-report-from-the-children-s-oncology-group
#12
Amy K Erbe, Wei Wang, Lakeesha Carmichael, KyungMann Kim, Eneida A Mendonca, Yiqiang Song, Dustin Hess, Patrick K Reville, Wendy B London, Arlene Naranjo, Jacquelyn A Hank, Mitchell B Diccianni, Ralph A Reisfeld, Stephen D Gillies, Katherine K Matthay, Susan L Cohn, Michael D Hogarty, John M Maris, Julie R Park, Mehmet Fevzi Ozkaynak, Andrew Gilman, Alice L Yu, Paul M Sondel
PURPOSE: In 2010, a Children's Oncology Group (COG) phase III randomized trial for high-risk neuroblastoma patients (ANBL0032) demonstrated improved event-free survival (EFS) and overall survival (OS) following treatment with an immunotherapy regimen of dinutuximab, GM-CSF, IL-2, and isotretinoin compared to treatment with isotretinoin alone. Dinutuximab, a chimeric anti-GD2 monoclonal antibody, acts in part via NK cells. Killer Immunoglobulin-like Receptors (KIRs) on NK cells and their interactions with KIR-ligands can influence NK cell function...
October 2, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28964020/interplay-of-spin-dependent-delocalization-and-magnetic-anisotropy-in-the-ground-and-excited-states-of-gd2-c78-and-gd2-c80
#13
Akseli Mansikkamäki, Alexey A Popov, Qingming Deng, Naoya Iwahara, Liviu F Chibotaru
The magnetic properties and electronic structure of the ground and excited states of two recently characterized endohedral metallo-fullerenes, [Gd2@C78](-) (1) and [Gd2@C80](-) (2), have been studied by theoretical methods. The systems can be considered as [Gd2](5+) dimers encapsulated in a fullerene cage with the fifteen unpaired electrons ferromagnetically coupled into an S = 15/2 high-spin configuration in the ground state. The microscopic mechanisms governing the Gd-Gd interactions leading to the ferromagnetic ground state are examined by a combination of density functional and ab initio calculations and the full energy spectrum of the ground and lowest excited states is constructed by means of ab initio model Hamiltonians...
September 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28940863/a-phase-ii-study-of-radioimmunotherapy-with-intraventricular-131-i-3f8-for-medulloblastoma
#14
Kim Kramer, Neeta Pandit-Taskar, John L Humm, Pat B Zanzonico, Sofia Haque, Ira J Dunkel, Suzanne L Wolden, Maria Donzelli, Debra A Goldman, Jason S Lewis, Serge K Lyashchenko, Yasmin Khakoo, Jorge A Carrasquillo, Mark M Souweidane, Jeffrey P Greenfield, David Lyden, Kevin D De Braganca, Stephen W Gilheeney, Steven M Larson, Nai-Kong V Cheung
BACKGROUND: High-risk and recurrent medulloblastoma (MB) is associated with significant mortality. The murine monoclonal antibody 3F8 targets the cell-surface disialoganglioside GD2 on MB. We tested the efficacy, toxicity, and dosimetry of compartmental radioimmunotherapy (cRIT) with intraventricular (131) I-labeled 3F8 in patients with MB on a phase II clinical trial. METHODS: Patients with histopathologically confirmed high-risk or recurrent MB were eligible for cRIT...
September 22, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28939747/a-pilot-trial-of-humanized-anti-gd2-monoclonal-antibody-hu14-18k322a-with-chemotherapy-and-natural-killer-cells-in-children-with-recurrent-refractory-neuroblastoma
#15
Sara M Federico, M Beth McCarville, Barry L Shulkin, Paul M Sondel, Jacquelyn A Hank, Paul Hutson, Michael Meagher, Aaron Shafer, Catherine Y Ng, Wing Leung, William E Janssen, Jianrong Wu, Shenghua Mao, Rachel C Brennan, Victor M Santana, Alberto S Pappo, Wayne L Furman
Purpose: Anti-GD2 mAbs, acting via antibody-dependent cell-mediated cytotoxicity, may enhance the effects of chemotherapy. This pilot trial investigated a fixed dose of a unique anti-GD2 mAb, hu14.18K322A, combined with chemotherapy, cytokines, and haploidentical natural killer (NK) cells.Experimental Design: Children with recurrent/refractory neuroblastoma received up to six courses of hu14.18K322A (40 mg/m(2)/dose, days 2-5), GM-CSF, and IL2 with chemotherapy: cyclophosphamide/topotecan (courses 1,2), irinotecan/temozolomide (courses 3,4), and ifosfamide/carboplatin/etoposide (courses 5,6)...
November 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28924152/second-harmonic-generation-response-in-thermally-reconstructed-multiferroic-%C3%AE-gd2-moo4-3-thin-films
#16
Emerson Coy, Piotr Graczyk, Luis Yate, Karol Załęski, Jacek Gapiński, Piotr Kuświk, Sławomir Mielcarek, Feliks Stobiecki, Bogusław Mróz, Cesar Ferrater, Stefan Jurga
Gd2(MoO4)3 (GMO) is a well-studied multiferroic material that exhibits full ferroelectric and ferroelastic behavior at room temperature. However, its difficult stabilization in thin films has prevented the study and exploitation of its multiferroic properties in different architectures. Here, we report on the study of GMO thin films deposited on Si(001) substrates by Pulsed Laser Deposition (PLD). The physicochemical properties of the films are discussed and studied. Results obtained by X-ray diffraction, X-ray photoelectron spectroscopy, high resolution transmission microscopy and second harmonic generation show that the orthorhombic (β'-GMO) multiferroic phase can be stabilized and homogenized by post deposition thermal reconstruction...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28901952/photoluminescence-study-in-ho3-tm3-yb3-li-gd2-moo4-3-nanophosphors-for-near-white-light-emitting-diode-and-security-ink-applications
#17
Anita Kumari, Manisha Mondal, Vineet Kumar Rai, Satyendra Narayan Singh
Ho3+/Yb3+/Tm3+/Li+:Gd2(MoO4)3 nanophosphors successfully synthesized via solid state reaction method have been structurally and optically characterized. Under 980 nm diode laser excitation the nanophosphors emit intense blue, green, red and NIR emissions peaking at ~ 476 nm, ~ 543 nm, ~ 646 nm and ~ 798 nm corresponding to the 1G4→3H6 (Tm3+), 5F4, 5S2→5I8 (Ho3+), 5F5 →5I8 (Ho3+) and 3H4→3H6 (Tm3+) transitions respectively. The UC emission intensity enhancement in the Ho3+-Yb3+-Tm3+-Li+:Gd2(MoO4)3 nanophosphors for the green band is found to be ~ 367, ~ 50 and ~ 9 times compared to the singly Ho3+ doped, Ho3+-Yb3+ co-doped and Ho3+-Yb3+-Tm3+ tri-doped Gd2(MoO4)3 nanophosphors...
September 13, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28868758/programmed-cell-death-ligand-1-pd-l1-expression-is-not-a-predominant-feature-in-ewing-sarcomas
#18
Christian Spurny, Sareetha Kailayangiri, Silke Jamitzky, Bianca Altvater, Eva Wardelmann, Uta Dirksen, Jendrik Hardes, Wolfgang Hartmann, Claudia Rossig
BACKGROUND: Programmed cell death 1 (PD-1) receptor engagement on T cells by its ligand programmed cell death ligand 1 (PD-L1) is a key mechanism of immune escape, and antibody blockade of the interaction has emerged as an effective immunotherapeutic strategy in some cancers. The role and relevance of the PD-1 checkpoint in Ewing sarcoma (EwS) is not yet understood. PROCEDURE: Here, we investigated expression of PD-L1 and PD-1 in EwS by immunohistochemistry analysis of pretherapeutic tumor biopsies and in tumor xenografts following treatment with human T cells engineered to express a chimeric antigen receptor (CAR) against the tumor-associated antigen GD2 ...
September 4, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28858852/targeting-nf%C3%AE%C2%BAb-signaling-in-gd2-bcscs
#19
Khoa Nguyen, V Lokesh Battula
No abstract text is available yet for this article.
August 3, 2017: Aging
https://www.readbyqxmd.com/read/28813678/therapeutic-antibodies-to-ganglioside-gd2-evolved-from-highly-selective-germline-antibodies
#20
Eric Sterner, Megan L Peach, Marc C Nicklaus, Jeffrey C Gildersleeve
Antibodies play a crucial role in host defense and are indispensable research tools, diagnostics, and therapeutics. Antibody generation involves binding of genomically encoded germline antibodies followed by somatic hypermutation and in vivo selection to obtain antibodies with high affinity and selectivity. Understanding this process is critical for developing monoclonal antibodies, designing effective vaccines, and understanding autoantibody formation. Prior studies have found that antibodies to haptens, peptides, and proteins evolve from polyspecific germline antibodies...
August 15, 2017: Cell Reports
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