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https://www.readbyqxmd.com/read/28650722/optimized-dna-vaccine-enhanced-by-adjuvant-il28b-induces-protective-immune-responses-against-herpes-simplex-virus-type-2-in-mice
#1
Yan Zhou, Ziyan Wang, Yongqing Xu, Zeqiang Zhang, Rui Hua, Wei Liu, Chunlai Jiang, Yan Chen, Wenying Yang, Wei Kong
Antigen-specific immune responses determine the efficacy of herpes simplex virus type 2 (HSV-2) vaccines. To optimize the immunogenicity of the antigen gD2, we developed the gD2ΔUL25 DNA vaccine encoding HSV-2 glycoprotein D and UL25 gene encoding viral capsid vertex proteins in this study. The gD2 and gD2ΔUL25 DNA vaccines were compared with formalin-inactivated HSV-2 (FI-HSV-2), and results showed a greater protective immune response induced by gD2ΔUL25 than by gD2. Therefore, gD2ΔUL25 was chosen to evaluate further using the IL28B adjuvant...
June 26, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28636755/technical-note-combination-of-multiple-epid-imager-layers-improves-image-quality-and-tracking-performance-of-low-contrast-to-noise-objects
#2
Stephen Sf Yip, Joerg Rottmann, Haijian Chen, Daniel Morf, Rony Füglistaller, Josh Star-Lack, George Zentai, Ross Berbeco
PURPOSE: We hypothesized that combining multiple amorphous silicon flat panel layers increases photon detection efficiency in an electronic portal imaging device (EPID), improving image quality and tracking accuracy of low contrast targets during radiotherapy METHODS: The prototype imager evaluated in this study contained 4 individually programmable layers each with a copper converter layer, Gd2 O2 S scintillator and active-matrix flat panel imager (AMFPI). The imager was placed on a Varian TrueBeam linac and a Las Vegas phantom programmed with sinusoidal motion (peak-to-peak amplitude=20mm, Period=3...
June 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28614387/global-sensing-of-the-antigenic-structure-of-herpes-simplex-virus-gd-using-high-throughput-array-based-spr-imaging
#3
Tina M Cairns, Noah T Ditto, Huan Lou, Benjamin D Brooks, Doina Atanasiu, Roselyn J Eisenberg, Gary H Cohen
While HSV-2 typically causes genital lesions, HSV-1 is increasingly the cause of genital herpes. In addition, neonatal HSV infections are associated with a high rate of mortality and HSV-2 may increase the risk for HIV or Zika infections, reinforcing the need to develop an effective vaccine. In the GSK Herpevac trial, doubly sero-negative women were vaccinated with a truncated form of gD2 [gD2(284t)], then examined for anti-gD serum titers and clinical manifestations of disease. Surprisingly, few vaccinees were protected against genital HSV-2 but 86% were protected from genital HSV-1...
June 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28602436/car-t-cells-administered-in-combination-with-lymphodepletion-and-pd-1-inhibition-to-patients-with-neuroblastoma
#4
Andras Heczey, Chrystal U Louis, Barbara Savoldo, Olga Dakhova, April Durett, Bambi Grilley, Hao Liu, Mengfeng F Wu, Zhuyong Mei, Adrian Gee, Birju Mehta, Huimin Zhang, Nadia Mahmood, Haruko Tashiro, Helen E Heslop, Gianpietro Dotti, Cliona M Rooney, Malcolm K Brenner
Targeting disialoganglioside (GD2) on neuroblastoma (NB) with T cells expressing a first-generation chimeric antigen receptor (CAR) was safe, but the cells had poor expansion and long-term persistence. We developed a third-generation GD2-CAR (GD2-CAR3) and hypothesized that GD2-CAR3 T cells (CARTs) would be safe and effective. This phase 1 study enrolled relapsed or refractory NB patients in three cohorts. Cohort 1 received CART alone, cohort 2 received CARTs plus cyclophosphamide and fludarabine (Cy/Flu), and cohort 3 was treated with CARTs, Cy/Flu, and a programmed death-1 (PD-1) inhibitor...
June 8, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28594418/microemulsion-made-gadolinium-carbonate-hollow-nanospheres-showing-magnetothermal-heating-and-drug-release
#5
J Jung-König, M Sanhaji, R Popescu, C Seidl, E Zittel, U Schepers, D Gerthsen, I Hilger, C Feldmann
Gadolinium carbonate (Gd2(CO3)3) hollow nanospheres and their suitability for drug transport and magnetothermally-induced drug release are presented. The hollow nanospheres are prepared via a microemulsion-based synthesis using tris(tetramethylcyclopentadienyl)gadolinium(iii) and CO2 as the starting materials. Size, structure and composition of the as-prepared Gd2(CO3)3 hollow nanospheres are comprehensively validated by several independent analytical methods (HRTEM, HAADF-STEM, DLS, EDXS, XRD, FT-IR, DTA-TG)...
June 8, 2017: Nanoscale
https://www.readbyqxmd.com/read/28583105/characteristics-and-potentials-of-stem-cells-derived-from-human-degenerated-nucleus-pulposus-potential-for-regeneration-of-the-intervertebral-disc
#6
Xiao-Chuan Li, Yong Tang, Jian-Hong Wu, Pu-Shan Yang, De-Li Wang, Di-Ke Ruan
BACKGROUND: Eliminating the symptoms during treatment of intervertebral disc degeneration (IVDD) is only a temporary solution that does not cure the underlying cause. A biological method to treat this disorder may be possible by the newly discovered nucleus pulposus derived stem cells (NPDCs). However, the uncertain characteristics and potential of NPDCs calls for a comprehensive study. METHODS: In the present study, nucleus pulposus samples were obtained from 5 patients with IVDD undergoing discectomy procedure and NPDCs were harvested using fluorescence activated cell sorting (FACS) by the co-expression of GD2(+) and Tie2(+)...
June 5, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28574176/a-photosensitizer-lanthanide-nanoparticle-formulation-that-induces-singlet-oxygen-with-direct-light-excitation-but-not-by-photon-or-x-ray-energy-transfer
#7
Rima Chouikrat, Francis Baros, Jean-Claude André, Régis Vanderesse, Bruno Viana, Anne-Laure Bulin, Christophe Dujardin, Philippe Arnoux, Marc Verelst, Céline Frochot
We report the design and synthesis of europium-doped gadolinium oxysulfide nanoscintillators Gd2 O2 S:Eu(3+) conjugated with two different photosensitizers (PSs): a zinc chlorin (ZnTPC) and a zinc phtalocyanine (ZnPc) by covalent bonding through a layer of N-(3-trimethoxysilylpropyl)diethylenetriamine (TPDA). These conjugates were designed to be activated under X-ray excitation to allow a photodynamic effect, although this desired outcome was not achieved in this study. The monodispersed nanoparticles of ∼70 nm diameter were pegylated to be stabilized in aqueous suspension...
June 2, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28570663/rectal-administration-of-a-chlamydial-subunit-vaccine-protects-against-genital-infection-and-upper-reproductive-tract-pathology-in-mice
#8
Roshan Pais, Yusuf Omosun, Qing He, Uriel Blas-Machado, Carolyn Black, Joseph U Igietseme, Kohtaro Fujihashi, Francis O Eko
In this study, we tested the hypothesis that rectal immunization with a VCG-based chlamydial vaccine would cross-protect mice against heterologous genital Chlamydia trachomatis infection and Chlamydia-induced upper genital tract pathologies in mice. Female mice were immunized with a C. trachomatis serovar D-derived subunit vaccine or control or live serovar D elementary bodies (EBs) and the antigen-specific mucosal and systemic immune responses were characterized. Vaccine efficacy was determined by evaluating the intensity and duration of genital chlamydial shedding following intravaginal challenge with live serovar E chlamydiae...
2017: PloS One
https://www.readbyqxmd.com/read/28549783/irinotecan-temozolomide-with-temsirolimus-or-dinutuximab-in-children-with-refractory-or-relapsed-neuroblastoma-cog-anbl1221-an-open-label-randomised-phase-2-trial
#9
Rajen Mody, Arlene Naranjo, Collin Van Ryn, Alice L Yu, Wendy B London, Barry L Shulkin, Marguerite T Parisi, Sabah-E-Noor Servaes, Mitchell B Diccianni, Paul M Sondel, Julia G Bender, John M Maris, Julie R Park, Rochelle Bagatell
BACKGROUND: Outcomes for children with relapsed and refractory neuroblastoma are dismal. The combination of irinotecan and temozolomide has activity in these patients, and its acceptable toxicity profile makes it an excellent backbone for study of new agents. We aimed to test the addition of temsirolimus or dinutuximab to irinotecan-temozolomide in patients with relapsed or refractory neuroblastoma. METHODS: For this open-label, randomised, phase 2 selection design trial of the Children's Oncology Group (COG; ANBL1221), patients had to have histological verification of neuroblastoma or ganglioneuroblastoma at diagnosis or have tumour cells in bone marrow with increased urinary catecholamine concentrations at diagnosis...
May 23, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28537895/interaction-of-glycosphingolipids-gd3-and-gd2-with-growth-factor-receptors-maintains-breast-cancer-stem-cell-phenotype
#10
Yuh-Jin Liang, Chen-Yu Wang, I-An Wang, Yi-Wen Chen, Li-Tzu Li, Chuang-Yu Lin, Ming-Yi Ho, Tsung-Lung Chou, Ya-Hui Wang, Shih-Pin Chiou, Yu-Ju Lin, John Yu
Many studies have suggested that disialogangliosides, GD2 and GD3, are involved in the development of various tumor types. However, the functional relationships between ganglioside expression and cancer development or aggressiveness are not fully described. GD3 is upregulated in approximately half of all invasive ductal breast carcinoma cases, and enhanced expression of GD3 synthase (GD3S, alpha-N-acetylneuraminide alpha-2,8-sialyltransferase) in estrogen receptor-negative breast tumors, was shown to correlate with reduced overall patient survival...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28536081/structural-annotation-of-beta-1-4-n-acetyl-galactosaminyltransferase-1-b4galnt1-causing-hereditary-spastic-paraplegia-26
#11
Rubina Dad, Uzma Malik, Aneela Javed, Berge A Minassian, Muhammad Jawad Hassan
Beta-1,4-N-acetyl galactosaminyltransferase 1, B4GALNT1, is a GM2/GD2 synthase, involved in the expression of glycosphingolipids (GSLs) containing sialic acid. Mutations in the gene B4GALNT1 cause Hereditary Spastic Paraplegia 26 (HSP26). In present study we have made attempt to predict the potential structural of the human B4GALNT1 protein. The results illustrated that the amino acid sequences of B4GALNT1 are not 100% conserved among selected twenty species. One signal peptide and one transmembrane domain predicted in human wild type B4GALNT1 protein with aliphatic index of 92...
May 20, 2017: Gene
https://www.readbyqxmd.com/read/28535413/controllable-synthesis-and-luminescent-properties-of-rare-earth-doped-gd2-moo4-3-nanoplates
#12
Lei Zhang, Bohua Dong, Guohua Wang, Rongjie Gao, Ge Su, Wei Wang, Lixin Cao
For the first time, we have successfully synthesized rare-earth doped Gd2(MoO4)3: RE(3+) (RE=Eu, Tb) nanoplates by solvothermal method. The morphology of Gd2(MoO4)3 can be manipulated by changing the reaction times and reaction temperatures. The composition and surface morphology have been investigated by X-ray powder diffraction (XRD) and transmission electron microscopy (TEM), respectively. Under the excitation of UV, Photoluminescence (PL) has been used to explore the excellent luminescence properties of the synthesized nanophosphors...
April 21, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28497656/identification-of-atypical-porcine-pestivirus-infection-in-swine-herds-in-china
#13
K Zhang, K Wu, J Liu, S Ge, Y Xiao, Y Shang, Z Ning
Atypical porcine pestivirus (APPV) have been detected in swine herds from the USA, Germany, the Netherlands, Spain and most recently in Austria, suggesting a wide geographic distribution of this novel virus. Here, for the first time, we reported APPV infection in swine herds in China. Newborn piglets from two separate swine herds in Guangdong province were found showing typical congenital tremors in July and August 2016. RT-PCR, sequencing and phylogenetic analysis showed APPV infection occurred. Phylogenetic analysis showed that Chinese APPV strains, GD1 and GD2, formed independent branch from the USA, Germany and the Netherlands...
May 11, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28481687/a-trivalent-subunit-antigen-glycoprotein-vaccine-as-immunotherapy-for-genital-herpes-in-the-guinea-pig-genital-infection-model
#14
Sita Awasthi, Lauren M Hook, Carolyn E Shaw, Harvey M Friedman
An estimated 417 million people worldwide ages 15 to 49 are infected with herpes simplex virus type 2 (HSV-2), the most common cause of genital ulcer disease. Some individuals experience frequent recurrences of genital lesions, while others only have subclinical infection, yet all risk transmitting infection to their intimate partners. A vaccine was developed that prevents shingles, which is a recurrent infection caused by varicella-zoster virus (VZV), a closely related member of the Herpesviridae family. The success of the VZV vaccine has stimulated renewed interest in a therapeutic vaccine for genital herpes...
May 8, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28475280/high-temperature-mass-spectrometric-study-of-the-vaporization-processes-and-thermodynamic-properties-in-the-gd2-o3-y2-o3-hfo2-system
#15
Eugene N Kablov, Valentina L Stolyarova, Sergey I Lopatin, Viktor A Vorozhtcov, Fedor N Karachevtsev, Yuriy I Folomeikin
RATIONALE: The refractory properties of the Gd2 O3 -Y2 O3 -HfO2 system are considered promising for the production of many high-temperature materials, e.g., thermal barrier coatings and casting molds for gas turbine engine blades. At high temperatures, components of the Gd2 O3 -Y2 O3 -HfO2 system may vaporize selectively and this may significantly change the physicochemical properties of the materials. Therefore, information on vaporization processes and thermodynamic properties of the Gd2 O3 -Y2 O3 -HfO2 system is of great importance...
July 15, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28415808/ikk-inhibition-by-bms-345541-suppresses-breast-tumorigenesis-and-metastases-by-targeting-gd2-cancer-stem-cells
#16
Venkata Lokesh Battula, Khoa Nguyen, Jeff Sun, Mary Kathryn Pitner, Bin Yuan, Chandra Bartholomeusz, Numsen Hail, Michael Andreeff
We have identified that the ganglioside GD2 is a marker for breast cancer stem cells (BCSCs), and that targeting the enzyme GD3 synthase (GD3S, which regulates GD2 biosynthesis) reduces breast tumorigenesis. The pathways regulating GD2 expression, and their anomalous functions in BCSC, are unclear. Proteomic analysis of GD2+ and GD2- cells from breast cancer cell lines revealed the activation of NFκB signaling in GD2+ cells. Dose- and time-dependent suppression of NFκB signaling by the small molecule inhibitor BMS-345541 reduced GD2+ cells by > 90%...
June 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415563/gd2-expression-in-breast-cancer
#17
Giulia Orsi, Monica Barbolini, Guido Ficarra, Giovanni Tazzioli, Paola Manni, Tiziana Petrachi, Ilenia Mastrolia, Enrico Orvieto, Carlotta Spano, Malvina Prapa, Shaniko Kaleci, Roberto D'Amico, Valentina Guarneri, Maria Vittoria Dieci, Stefano Cascinu, Pierfranco Conte, Federico Piacentini, Massimo Dominici
Breast cancer (BC) is a heterogeneous disease, including different subtypes having diverse incidence, drug-sensitivity and survival rates. In particular, claudin-low and basal-like BC have mesenchymal features with a dismal prognosis. Disialoganglioside GD2 is a typical neuroectodermal antigen expressed in a variety of cancers. Despite its potential relevance in cancer diagnostics and therapeutics, the presence and role of GD2 require further investigation, especially in BC. Therefore, we evaluated GD2 expression in a cohort of BC patients and its correlation with clinical-pathological features...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412222/targeted-drug-distribution-in-tumor-extracellular-fluid-of-gd2-expressing-neuroblastoma-patient-derived-xenografts-using-sn-38-loaded-nanoparticles-conjugated-to-the-monoclonal-antibody-3f8
#18
Carles Monterrubio, Sonia Paco, Nagore G Olaciregui, Guillem Pascual-Pasto, Monica Vila-Ubach, Maria Cuadrado-Vilanova, M Mar Ferrandiz, Helena Castillo-Ecija, Romina Glisoni, Nataliya Kuplennik, Achim Jungbluth, Carmen de Torres, Cinzia Lavarino, Nai-Kong V Cheung, Jaume Mora, Alejandro Sosnik, Angel M Carcaboso
Neuroblastoma is a pediatric solid tumor with high expression of the tumor associated antigen disialoganglioside GD2. Despite initial response to induction therapy, nearly 50% of high-risk neuroblastomas recur because of chemoresistance. Here we encapsulated the topoisomerase-I inhibitor SN-38 in polymeric nanoparticles (NPs) surface-decorated with the anti-GD2 mouse mAb 3F8 at a mean density of seven antibody molecules per NP. The accumulation of drug-loaded NPs targeted with 3F8 versus with control antibody was monitored by microdialysis in patient-derived GD2-expressing neuroblastoma xenografts...
June 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28393238/modulation-of-interactions-of-neuroblastoma-cell-lines-with-extracellular-matrix-proteins-affects-their-sensitivity-to-treatment-with-the-anti-gd2-ganglioside-antibody-14g2a
#19
Irena Horwacik, Hanna Rokita
Children diagnosed with high risk neuroblastoma have poor prognosis which stimulates efforts to broaden therapies of the neoplasm. GD2-ganglioside (GD2) marks neuroblastoma cells and is a target for monoclonal antibodies. We have recently shown that some neuroblastoma cell lines are sensitive to direct cytotoxicity of the anti-GD2 mouse monoclonal antibody 14G2a (mAb). For IMR-32 and LA-N-1 cell lines, treatment with the 14G2a mAb induced evident changes in appearance such as cell rounding, aggregation, loose contact with culture plastic, or detachment...
April 7, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28389455/dinutuximab-for-maintenance-therapy-in-pediatric-neuroblastoma
#20
REVIEW
Lauren McGinty, Jill Kolesar
PURPOSE: The pharmacology, clinical efficacy, safety, dosage and administration, and role in therapy of dinutuximab for the treatment of high-risk pediatric neuroblastoma are reviewed. SUMMARY: Dinutuximab (Unituxin, United Therapeutics) is a novel monoclonal antibody recently approved for use in combination with granulocyte- macrophage colony-stimulating factor, interleukin-2, and isotretinoin for the treatment of pediatric patients with high-risk neuroblastoma...
April 15, 2017: American Journal of Health-system Pharmacy: AJHP
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