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https://www.readbyqxmd.com/read/29791513/vaccine-induced-antibodies-to-herpes-simplex-virus-glycoprotein-d-epitopes-involved-in-virus-entry-and-cell-to-cell-spread-correlate-with-protection-against-genital-disease-in-guinea-pigs
#1
Lauren M Hook, Tina M Cairns, Sita Awasthi, Benjamin D Brooks, Noah T Ditto, Roselyn J Eisenberg, Gary H Cohen, Harvey M Friedman
Herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) subunit antigen is included in many preclinical candidate vaccines. The rationale for including gD2 is to produce antibodies that block crucial gD2 epitopes involved in virus entry and cell-to-cell spread. HSV-2 gD2 was the only antigen in the Herpevac Trial for Women that protected against HSV-1 genital infection but not HSV-2. In that trial, a correlation was detected between gD2 ELISA titers and protection against HSV-1, supporting the importance of antibodies...
May 23, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29789847/streamlined-chemoenzymatic-total-synthesis-of-prioritized-ganglioside-cancer-antigens
#2
Hai Yu, Abhishek Santra, Yanhong Li, John B McArthur, Tamashree Ghosh, Xiaoxiao Yang, Peng G Wang, Xi Chen
A highly efficient streamlined chemoenzymatic strategy for total synthesis of four prioritized ganglioside cancer antigens GD2, GD3, fucosyl GM1, and GM3 from commercially available lactose and phytosphingosine is demonstrated. Lactosyl sphingosine (LacβSph) was chemically synthesized (on a 13 g scale), subjected to sequential one-pot multienzyme (OPME) glycosylation reactions with facile C18-cartridge purification, followed by improved acylation conditions to form target gangliosides, including fucosyl GM1 which has never been synthesized before...
May 23, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29747824/congenital-disorders-of-ganglioside-biosynthesis
#3
T August Li, Ronald L Schnaar
Gangliosides are expressed on all vertebrate cells and tissues, but are particularly abundant in the mammalian brain, where they constitute major cell-surface determinants on all nerve cells. The same four ganglioside structures, GM1, GD1a, GD1b, and GT1b, constitute the great majority of brain gangliosides in all mammals. Biosynthesis of these major brain gangliosides starts with addition of glucose to the ceramide lipid carrier followed by stepwise addition of up to six additional monosaccharides. This primarily involves the sequential action of seven glycosyltransferases, many of which appear to act specifically on glycolipid (rather than glycoprotein) acceptors...
2018: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29747823/gangliosides-%C3%AE-synuclein-and-parkinson-s-disease
#4
Robert W Ledeen, Gusheng Wu
This review addresses the role of α-synuclein (αSyn) in the etiopathology of Parkinson's disease (PD), with emphasis on its interaction with GM1 ganglioside. We begin with a brief review of some of the milestone discoveries that helped to elucidate PD neuropathology, including the fibrous inclusions of Lewy that characterize the degenerating dopaminergic neurons of the substantia nigra and the presence of αSyn as a major constituent of these Lewy bodies and neurites. This enabled Braak et al. to define the progressive nature of PD in developing their staging hypothesis which described the topographically predictable sequence of neuropathological changes giving rise to prodromal nonmotor symptoms that precede the classical motor dysfunctions...
2018: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29747814/gangliosides-in-cancer-cell-signaling
#5
Sophie Groux-Degroote, Macarena Rodríguez-Walker, Justine H Dewald, Jose L Daniotti, Philippe Delannoy
At the outer leaflet of the plasma membrane, gangliosides are found with other glycosphingolipids, phospholipids, and cholesterol in glycolipid-enriched microdomains, in which they interact with signaling molecules including receptor tyrosine kinases and signal transducers. The role of gangliosides in the regulation of signal transduction has been reported for many cases and in different cell types. The biosynthesis of gangliosides involves specific enzymes, mainly glycosyltransferases that control together with glycohydrolases, the steady state of gangliosides at the cell surface...
2018: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29735770/spinal-nerve-roots-contrast-enhancement-following-anti-gd2-antibody-therapy-in-neuroblastoma
#6
Giovanni Morana, Paola Lanteri, Domenico Tortora, Carola Martinetti, Alberto Garaventa
No abstract text is available yet for this article.
May 8, 2018: Neurology
https://www.readbyqxmd.com/read/29734089/magnetic-luminescent-cerium-doped-gadolinium-aluminum-garnet-nanoparticles-for-simultaneous-imaging-and-photodynamic-therapy-of-cancer-cells
#7
Akhil Jain, Rina Koyani, Carlos Muñoz, Prakhar Sengar, Oscar E Contreras, Patricia Juárez, Gustavo A Hirata
Nanoparticle (NP) and photosensitizer (PS) conjugates capable of X-ray photodynamic therapy (X-PDT) are a research focus due to their potential applications in cancer treatment. Combined with X-PDT, appropriate imaging properties of the nanocomposite will make it suitable for theranostics of deep lying tumors. In this work, we describe the development of magnetic-luminescent Gd2.98 Ce0.02 Al5 O12 nanoparticles (GAG) coated with mesoporous silica (mSiO2 ) and loaded with rose bengal (RB) to yield a nanocomposite GAG@mSiO2 @RB capable of X-PDT...
April 27, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29703828/anti-gd2-car-t-cells-are-potent-in-h3-k27m-diffuse-midline-gliomas
#8
(no author information available yet)
The disialoganglioside GD2 is an immunotherapeutic target in H3-K27M+ diffuse midline gliomas.
April 27, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29698439/tnf-differentially-regulates-ganglioside-biosynthesis-and-expression-in-breast-cancer-cell-lines
#9
Justine H Dewald, Sumeyye Cavdarli, Agata Steenackers, Clément P Delannoy, Marlène Mortuaire, Corentin Spriet, Maxence Noël, Sophie Groux-Degroote, Philippe Delannoy
Gangliosides are glycosphingolipids concentrated in glycolipid-enriched membrane microdomains. Mainly restricted to the nervous system in healthy adult, complex gangliosides such as GD3 and GD2 have been shown to be involved in aggressiveness and metastasis of neuro-ectoderm derived tumors such as melanoma and neuroblastoma. GD3 synthase (GD3S), the key enzyme that controls the biosynthesis of complex gangliosides, was shown to be over-expressed in Estrogen Receptor (ER)-negative breast cancer tumors, and associated with a decreased overall survival of patients...
2018: PloS One
https://www.readbyqxmd.com/read/29697952/in-situ-synthesis-of-cds-graphdiyne-heterojunction-for-enhanced-photocatalytic-activity-of-hydrogen-production
#10
Jia-Xin Lv, Zhi-Ming Zhang, Juan Wang, Xiu-Li Lu, Wen Zhang, Tong-Bu Lu
Hydrogen production through artificial photosynthesis has been regarded as a promising strategy for dealing with energy shortage and environmental problems. In this work, graphdiyne (GD) was first introduced to the visible-light catalytic system for hydrogen production, in which a CdS/GD heterojunction was prepared through a simple in situ growth process by adding Cd(AcO)2 into a dimethyl sulfoxide (DMSO) solution containing GD substrate. The as-prepared CdS/GD heterojunction exhibits much higher performance for photocatalytic hydrogen evolution compared to that of pristine GD and CdS nanoparticles...
April 26, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29690883/gamma-rays-excited-radioluminescence-tomographic-imaging
#11
Xuanxuan Zhang, Shouping Zhu, Yang Li, Yonghua Zhan, Xueli Chen, Fei Kang, Jing Wang, Xu Cao
BACKGROUND: Radionuclide-excited luminescence imaging is an optical radionuclide imaging strategy to reveal the distributions of radioluminescent nanophosphors (RLNPs) inside small animals, which uses radioluminescence emitted from RLNPs when excited by high energy rays such as gamma rays generated during the decay of radiotracers used in clinical nuclear medicine imaging. Currently, there is no report of tomographic imaging based on radioluminescence. METHODS: In this paper, we proposed a gamma rays excited radioluminescence tomography (GRLT) to reveal three-dimensional distributions of RLNPs inside a small animal using radioluminescence through image reconstruction from surface measurements of radioluminescent photons using an inverse algorithm...
April 24, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29676233/chimeric-antigen-receptor-t-cell-based-immunotherapy-for-cancer
#12
Feng Li, Tengfei Zhang, Ling Cao, Yi Zhang
Cancer immunotherapy, a new weapon against cancers by harnessing the patient's own immune system, potentiates an extended remission and possibly a cure for cancer. T cells genetically engineered with chimeric antigen receptor (CAR) vectors can specifically target the surface antigen of cancer cells and kill them in an MHC-independent manner. CD19 is extensively expressed on cancerous cells in B cell malignancies. To target this antigen, CAR T cells have gained great success in treating patients with B cell leukemia and lymphoma...
April 19, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29662203/potent-antitumor-efficacy-of-anti-gd2-car-t-cells-in-h3-k27m-diffuse-midline-gliomas
#13
Christopher W Mount, Robbie G Majzner, Shree Sundaresh, Evan P Arnold, Meena Kadapakkam, Samuel Haile, Louai Labanieh, Esther Hulleman, Pamelyn J Woo, Skyler P Rietberg, Hannes Vogel, Michelle Monje, Crystal L Mackall
Diffuse intrinsic pontine glioma (DIPG) and other diffuse midline gliomas (DMGs) with mutated histone H3 K27M (H3-K27M)1-5 are aggressive and universally fatal pediatric brain cancers 6 . Chimeric antigen receptor (CAR)-expressing T cells have mediated impressive clinical activity in B cell malignancies7-10 , and recent results suggest benefit in central nervous system malignancies11-13 . Here, we report that patient-derived H3-K27M-mutant glioma cell cultures exhibit uniform, high expression of the disialoganglioside GD2...
April 16, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29602057/structure-and-chemistry-of-interfaces-between-ceria-and-yttria-stabilized-zirconia-studied-by-analytical-stem
#14
H Schmid, E Gilardi, G Gregori, P Longo, J Maier, P A van Aken
Epitaxial undoped and Gd2 O3 -doped ceria films were grown by pulsed laser deposition on (1 1 1) faced Y2 O3 -stabilized zirconia (YSZ). Highly localized cerium reduction at the film-substrate interfaces is revealed by atomically resolved valence EELS mapping using Cs aberration-corrected scanning transmission electron microscopy. The chemical profiles reveal interdiffusion of Ce, (Gd), Y, Zr, forming an intermixing zone at the interface 7-9 (1 1 1) lattice planes wide. In its vicinity, the fraction of Ce3+ raises gradually over 6-8 lattice planes from zero in the bulk ceria to ≈100% in one single plane at the interface...
January 31, 2018: Ultramicroscopy
https://www.readbyqxmd.com/read/29580992/comparative-toxicity-and-contrast-enhancing-assessments-of-gd-2-o-3-bsa-and-mno-2-bsa-nanoparticles-for-mr-imaging-of-brain-glioma
#15
Hong Zhang, Tingjian Wang, Yuanyuan Zheng, Changxiang Yan, Wei Gu, Ling Ye
The albumin-templated Gd2 O3 and MnO2 nanoparticles (NPs) have been developed as a new type of magnetic resonance (MR) T1 contrast agents. However, their potential toxicity and applicability for MR imaging of brain gliomas has not been fully explored so far. In this study, we prepared Gd2 O3 @BSA and MnO2 @BSA nanoparticles (NPs) and investigated their toxicity comprehensively and comparatively by H&E staining, blood biochemical analysis, and adverse outcome pathways testing. It is revealed that both Gd2 O3 @BSA and MnO2 @BSA NPs are biocompatibility at a rational dose level...
March 23, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29574715/treatment-and-outcome-of-adult-onset-neuroblastoma
#16
Maya Suzuki, Brian H Kushner, Kim Kramer, Ellen M Basu, Stephen S Roberts, William J Hammond, Michael P LaQuaglia, Suzanne L Wolden, Nai-Kong V Cheung, Shakeel Modak
Adult-onset neuroblastoma is rare and little is known about its biology and clinical course. There is no established therapy for adult-onset neuroblastoma. Anti-GD2 immunotherapy is now standard therapy in children with high-risk neuroblastoma; however, its use has not been reported in adults. Forty-four adults (18-71 years old) diagnosed with neuroblastoma between 1979 and 2015 were treated at Memorial Sloan Kettering Cancer Center. Five, 1, 5 and 33 patients had INSS stage 1, 2, 3 and 4 diseases, respectively...
March 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29566719/functionalized-rare-earth-doped-nanoparticles-for-breast-cancer-nanodiagnostic-using-fluorescence-and-ct-imaging
#17
Akhil Jain, Pierrick G J Fournier, Vladimir Mendoza-Lavaniegos, Prakhar Sengar, Fernando M Guerra-Olvera, Enrique Iñiguez, Thomas G Kretzschmar, Gustavo A Hirata, Patricia Juárez
BACKGROUND: Breast cancer is the second leading cause of cancer death among women and represents 14% of death in women around the world. The standard diagnosis method for breast tumor is mammography, which is often related with false-negative results leading to therapeutic delays and contributing indirectly to the development of metastasis. Therefore, the development of new tools that can detect breast cancer is an urgent need to reduce mortality in women. Here, we have developed Gd2 O3 :Eu3+ nanoparticles functionalized with folic acid (FA), for breast cancer detection...
March 22, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29528344/two-photon-graphene-quantum-dot-modified-gd-2-o-3-nanocomposites-as-a-dual-mode-mri-contrast-agent-and-cell-labelling-agent
#18
F H Wang, K Bae, Z W Huang, J M Xue
For obtaining high-resolution macroscopical anatomical information and high sensitivity microscopical optical signals, it is highly desirable to develop dual-modality magnetic resonance imaging (MRI) and fluorescent probes in medical imaging simultaneously. In this study, Gd2 O3 nanoparticles were modified with two-photon graphene quantum dots (GQD), integrating a magnetic resonance imaging (MRI) contrast agent with two-photon imaging functionality into one nanoprobe. A photoluminescence study indicated that the GQD modification process integrated MRI properties with both one-photon and two-photon imaging properties...
March 28, 2018: Nanoscale
https://www.readbyqxmd.com/read/29526740/polymer-based-gadolinium-oxide-nanocomposites-for-fl-mr-pa-imaging-guided-and-photothermal-photodynamic-combined-anti-tumor-therapy
#19
Yu Cheng, Xiaoxiao Tan, Jinping Wang, Yidan Wang, Yilin Song, Qing You, Qi Sun, Li Liu, Siyu Wang, Fengping Tan, Jiao Li, Nan Li
Recently, ultrasmall gadolinium oxide (Gd2 O3 ) nanoparticles with high longitudinal relaxation rate have received enormous attention. However, it can't be concentrated in tumor site through intravenous administration due to its ultrasmall size. In this project, we coated ultrasmall Gd2 O3 nanoparticles with a near-infrared (NIR) light-absorbing polymer polypyrrole (PPy), modifying with hyaluronic acid (HA) and loaded aluminum phthalocyanine (AlPc), the Gd2 O3 @PPy/AlPc-HA nanoparticles could be used for fluorescence (FL)/magnetic resonance (MR)/photoacoustic (PA) imaging guided as well as remotely controlled PTT/PDT combined anti-tumor therapy...
May 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29524730/antitumor-activity-and-carrier-properties-of-novel-hemocyanins-coupled-to-a-mimotope-of-gd2-ganglioside
#20
Miriam Palacios, Ricardo Tampe, Miguel Del Campo, Ta-Ying Zhong, Mercedes N López, Flavio Salazar-Onfray, María Inés Becker
Conjugation to carrier proteins is a way to improve the immunogenicity of peptides. Such is the case for peptides mimicking carbohydrate tumor-associated antigens in cancer vaccine development. The most used protein for this purpose is the keyhole limpet hemocyanin (KLH) from Megathura crenulata. Its limited bioavailability has prompted interest in finding new candidates; nevertheless, it is not known whether other hemocyanins might be equally efficient as carrier of carbohydrate peptide mimotopes to promotes anti-tumor responses...
April 25, 2018: European Journal of Medicinal Chemistry
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