Tevfik Demir, Abdurrahman Comlekçi, Omer Demir, Aytaç Gülcü, Sezer Calýpkan, Leyla Argun, Mustafa Seçil, Sena Yepil, Adil Esen
Nitric oxide (NO), the key mediator synthesized by different NO synthase isoenzymes, plays an important role in endothelial function. It was recently shown that hyperhomocysteinemia is an important regulator of NO synthase. We investigated the role of homocysteine (Hcys) in erectile dysfunction (ED), which is associated with the defect in NO generation. Thirty-one nondiabetic patients and 33 control cases were evaluated. Patients with diabetes, coronary artery disease, vitamin B(12), or folate deficiency were excluded in the study...
December 2006: Metabolism: Clinical and Experimental