keyword
https://read.qxmd.com/read/38522472/topical-oxygen-therapy-and-singlet-oxygen-in-wound-healing-a-scoping-review
#21
REVIEW
Martina Sýkorová, Christine Joy Moffatt, Neil Stentiford, Ewa Anna Burian, Sasagaki Katsuhiro, Yang Wei
The aim of this scoping review was to provide an overview of current research into topical oxygen therapies including the under-researched singlet oxygen for wound healing. A scoping review was undertaken using five databases. After duplicates and ineligible studies were excluded, 49 studies were included for a narrative review. Out of the included 49 studies, 45 (91.8%) were published in the past 10 years (2013-2023) with 32 (65.3%) published in the past 5 years (2018-2023). Eight of the studies were systematic reviews and/or meta-analysis and 18 were RCTs...
April 2024: International Wound Journal
https://read.qxmd.com/read/38522455/investigating-low-rates-of-compliance-to-graduated-compression-therapy-for-chronic-venous-insufficiency-a-systematic-review
#22
JOURNAL ARTICLE
Elise M Stevenson, Andrea Coda, Michael D J Bourke
Chronic venous insufficiency (CVI) is a chronic lower limb progressive disorder with significant burden. Graduated compression therapy is the gold-standard treatment, but its underutilisation, as indicated in recent literature, may be contributing to the growing burden of CVI. The aim of this systematic review is to determine the reasons for poor compliance in patients who are prescribed graduated compression therapy in the management of chronic venous insufficiency. A systematic review of the literature was conducted to identify the reasons for non-compliance in wearing graduated compression therapy in the management of chronic venous insufficiency...
April 2024: International Wound Journal
https://read.qxmd.com/read/38521704/follicular-unit-grafting-in-chronic-ulcers-a-valuable-technique-for-integrated-management
#23
JOURNAL ARTICLE
Anahi Belatti, Florencia Bertarini, Virginia Pombo, Luis Mazzuoccolo, Damian Ferrario
Chronic ulcers significantly affect the quality of life of patients and impose a high cost on the healthcare system. The therapeutic management should be comprehensive, taking into consideration the etiological diagnosis of the wound and the characteristics of the wound bed when deciding on a therapeutic proposal appropriate to the healing phase, correcting factors that delay healing. During the epithelialization phase, repair techniques with grafts are recommended to shorten re-epithelialization time, improve the quality of scar tissue, and achieve adequate pain management...
March 22, 2024: Anais Brasileiros de Dermatologia
https://read.qxmd.com/read/38520549/are-silver-coated-megaprostheses-superior-to-uncoated-megaprostheses-in-managing-chronic-end-stage-periprosthetic-hip-and-knee-infection
#24
JOURNAL ARTICLE
Matías Vicente, Josep Nomdedeu, Kushal Lakhani, Pablo S Corona
INTRODUCTION: Outcomes for silver coated megaprostheses (SC-MP) used in cases of end-stage periprosthetic joint infection (PJI) have not been clearly defined. Although attractive, concerns over implant longevity and the risk of infection relapse exist among the scientific community. Therefore, we sought to investigate the effect of silver coating in lower-extremity MPs used in such difficult-to-treat scenarios. The study's primary hypothesis was that the periprosthetic infection control rate would be higher in patients with silver-coated implants...
March 23, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38516949/optimization-and-validation-of-an-ftir-based-all-in-one-system-for-viable-mdr-bacteria-detection-in-combat-related-wound-infection
#25
JOURNAL ARTICLE
Ying Chen, Andrew Leung, Yulia Wang, Nathan K Archer
INTRODUCTION: The U.S. Military members experiencing combat-related injuries have a higher chance of developing infections by multidrug-resistant (MDR) bacteria at admission to military hospitals. MDR wound infections result in higher amputation rates and greater risks for subsequent or chronic infections that require readmission or extended stay in the hospital. Currently, there is no FDA-clear, deployable early diagnostic system for suitable field use.We are reporting our efforts to improve a previously developed Rapid Label-free Pathogen Identification (RAPID) system to detect viable MDR bacteria in wound infections and perform antibiotic susceptibility testing (AST)...
March 21, 2024: Military Medicine
https://read.qxmd.com/read/38515238/idiopathic-intracranial-hypertension-and-obstetric-and-neonatal-outcomes-a-1-20-matched-study-from-a-population-database
#26
JOURNAL ARTICLE
Uri Amikam, Haitham Baghlaf, Ahmad Badeghiesh, Richard Brown, Michael H Dahan
OBJECTIVE: Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is a common pathology in reproductive-aged women, although data regarding pregnancy outcomes are scarce. In the present study, we aimed to compare pregnancy and perinatal outcomes between women who suffered from IIH to those who did not. METHODS: A retrospective cohort study using the Healthcare Cost and Utilization Project, Nationwide Inpatient Sample. All pregnant women who delivered or had a maternal death in the US (2004-2014) were included...
March 21, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38514531/technical-note-preliminary-surgical-experience-with-a-new-implantable-epicranial-stimulation-device-for-chronic-focal-cortex-stimulation-in-drug-resistant-epilepsy
#27
JOURNAL ARTICLE
Volker A Coenen, Nadja Jarc, Martin Hirsch, Peter C Reinacher, Bernhard J Steinhoff, Thomas Bast, Andreas Schulze-Bonhage, Bastian E A Sajonz
PURPOSE: This study is to report some preliminary surgical considerations and outcomes after the first implantations of a new and commercially available implantable epicranial stimulation device for focal epilepsy. METHODS: We retrospectively analyzed data from clinical notes. Outcome parameters were as follows: wound healing, surgery time, and adverse events. RESULTS: Five patients were included (17-52 y/o; 3 female). Epicranial systems were uneventfully implanted under neuronavigation guidance...
March 22, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38514374/impact-of-foot-functionality-in-patients-with-systemic-sclerosis-cross-sectional-study
#28
JOURNAL ARTICLE
Esther Chicharro-Luna, Miguel Ángel Gracia-Vesga, Laura Ramos-Petersen, Gabriel Gijón-Nogueron
BACKGROUND: Progressive systemic sclerosis or systemic scleroderma (SS) is a chronic and rare autoimmune disease that mainly affects the skin and various internal organs. Raynaud's phenomenon and digital ulcers are some of the symptoms that affect the foot, causing a decrease in the quality of life of patients. The objective of this study is to determine the functionality of the feet in patients with SS and determine the impact on their daily lives. METHODS: A sample of 165 patients (154 women, 11 men) diagnosed with SS with a mean age of 46...
March 7, 2024: Journal of Tissue Viability
https://read.qxmd.com/read/38513152/intercalary-resection-of-the-tibia-for-primary-bone-tumors-are-vascularized-fibula-autografts-with-or-without-allografts-a-durable-reconstruction
#29
JOURNAL ARTICLE
Domenico Andrea Campanacci, Roberto Scanferla, Mariagrazia Marsico, Federico Scolari, Guido Scoccianti, Giovanni Beltrami, Luca Delcroix, Marco Innocenti, Rodolfo Capanna
BACKGROUND: Reconstruction with vascularized fibula grafts (VFG) after intercalary resection of sarcoma may offer longevity by providing early graft-host union and fracture healing. The ability of the fibula to hypertrophy under mechanical stress, as well as vascularized bone in the area, may also be advantageous, given that soft tissues may be compromised because of resection, chemotherapy, or radiation therapy. VFG with a massive allograft combines the primary mechanical stability of the graft with the biological potential of the vascularized fibula; however, complications and the durability of this combined reconstruction are not well described...
March 21, 2024: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/38512908/modified-in-vitro-aatcc-100-procedure-to-measure-viable-bacteria-from-wound-dressings
#30
JOURNAL ARTICLE
Sang Hyuk Lee, Thomas Glover, Nathan Lavey, Xiao Fu, Marc Donohue, Enusha Karunasena
Chronic wounds are reoccurring healthcare problems in the United States and cost up to $50 billion annually. Improper wound care results in complications such as wound debridement, surgical amputation, and increased morbidity/ mortality due to opportunistic infections. To eliminate wound infections, many antimicrobial dressings are developed and submitted to FDA for evaluation. AATCC-100 is a standard method widely used to evaluate cloth wound dressings. This method, requires enrichment, followed by culturing to measure the concentration of culturable organisms; a caveat to this method could result in neglected viable but nonculturable (VBNC) bacteria and overestimate the antimicrobial properties of wound dressings...
2024: PloS One
https://read.qxmd.com/read/38512592/pit-excision-with-fibrin-glue-closure-versus-lateralizing-flap-procedures-in-the-management-of-pilonidal-sinus-disease-in-adolescents-a-14-year-cohort-study
#31
JOURNAL ARTICLE
William Giles, Govind Murthi, Richard Lindley
INTRODUCTION: Pilonidal sinus disease (PSD) arises in the hair follicles of the gluteal cleft with many cases occurring during adolescence. Early studies of pit excision with fibrin glue closure (PEF), a minimally invasive procedure for the management of chronic PSD, suggest it is safe and effective with similar results to traditional lateralizing flap procedures (LFP), without the need for extensive tissue excision and associated complications. However, these studies lack large sample sizes and prolonged follow-up...
March 21, 2024: Pediatric Surgery International
https://read.qxmd.com/read/38512418/evaluation-of-management-of-ct-scan-proved-solid-organ-injury-in-blunt-injury-abdomen-a-prospective-study
#32
JOURNAL ARTICLE
Sourodip Mukharjee, Dinesh B V, Bharath S V
BACKGROUND: Trauma especially road traffic injury is one of the major health-related issues throughout the world, especially in developing countries like India (Mattox 2022). Solid organ injury is the most common cause of morbidity and mortality in patients with blunt abdominal trauma. The non-operative management (NOM) is being consistently followed for hemodynamically stable patients with respect to solid organ injuries. This study aims to provide an evidence base for management modalities of solid organ injuries in blunt abdominal trauma...
March 21, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/38512120/meta-analysis-on-glp-1-mediated-modulation-of-autophagy-in-islet-%C3%AE-cells-prospectus-for-improved-wound-healing-in-type-2-diabetes
#33
REVIEW
Wenjing Xia, Hua Yu, Pengcheng Wen
Type 2 diabetes mellitus refers to a significantly challenging health disease due to its high prevalence and risk of other chronic diseases across the world. Notably, GLP-1 has been recognized to enhance the treatment of T2DM, along with this, GLP-1 is also involved in autophagy modulation. However, ineffectiveness of few analogue types can limit the efficacy of this treatment. This study particularly aims to elucidate the influence of GLP-1 receptor analogues on wound infection and patients with type 2 diabetes...
April 2024: International Wound Journal
https://read.qxmd.com/read/38512118/how-effective-is-simple-mechanical-wound-debridement-in-reducing-bacterial-colonisation-results-of-a-prospective-clinical-study
#34
JOURNAL ARTICLE
Maurice Moelleken, Sebastian Heinrich Krimphove, Frederik Krefting, Sven Benson, Christos Rammos, Anna Ewa Cyrek, Joachim Dissemond
BACKGROUND AND AIMS: Bacteria in wounds can lead to stagnation of wound healing as well as to local or even systemic wound infections up to potentially lethal sepsis. Consequently, the bacterial load should be reduced as part of wound treatment. Therefore, the efficacy of simple mechanical wound debridement should be investigated in terms of reducing bacterial colonisation. PATIENTS AND METHODS: Patients with acute or chronic wounds were assessed for bacterial colonisation with a fluorescence camera before and after mechanical wound debridement with sterile cotton pads...
April 2024: International Wound Journal
https://read.qxmd.com/read/38511532/nanosheet-promotes-chronic-wound-healing-by-localizing-uncultured-stromal-vascular-fraction-cells
#35
JOURNAL ARTICLE
Shimpo Aoki, Yori Endo, Cynthia Guo, Mengfan Wu, Audrey Kim, Megumi Takuma, Jessica Mroueh, Luisa Weber, Toshinori Fujie, Kristo Nuutila, Indranil Sinha
OBJECTIVE: To develop an efficacious and efficient method for treating chronic wounds using "nanosheet" that improves the survival and localization of transplanted cells without prior seeding to optimally derive the regenerative potentials of uncultured stromal vascular fraction cells. APPROACH: We propose a method whereby the wound is covered by uncultured stromal vascular fraction cells using the nanosheet (porous poly(D,L,-lactic acid) (PDLLA) films) designed to hold cells in a single-cell layer...
March 21, 2024: Advances in Wound Care
https://read.qxmd.com/read/38511527/objective-evidence-that-nerve-decompression-surgery-reduces-neuropathic-dfu-recurrence-risk-to-less-than-5
#36
JOURNAL ARTICLE
Scott Nickerson, Dwayne S Yamasaki
SCOPE AND SIGNIFICANCE Care for the diabetic foot ulcer (DFU) continues to be a frustrating challenge. Standard of care (SOC) methods are plagued by regrettable levels of delayed healing, failures to heal, recurrence risk, and association with amputations and early mortality.1 We hope to bring attention to the clinical reports observing that diabetes is frequently accompanied by nerve trunk enlargement. Local sites of compression can then occur that cause neural dysfunction and pain, but respond to surgical nerve decompression (ND) and recover a degree of normal function...
March 21, 2024: Advances in Wound Care
https://read.qxmd.com/read/38511520/association-of-tryptophan-kynurenine-metabolites-with-healing-in-chronic-venous-leg-ulcers
#37
JOURNAL ARTICLE
Junglyun Kim, Joyce Stechmiller, Michael Weaver, Debra Lyon, Timothy J Garrett, Fan Yi, Jungmin Park, Magali Rezende de Carvalho, Debra Lynch Kelly
OBJECTIVE: Chronic wound healing is a complex process that is still not well understood. The tryptophan (TRP)-L-Kynurenine (KYN) pathway has recently been under increased scrutiny in regards to wound healing. The study applied metabolomics to elucidate the TRP-L- KYN pathway associated with wound healing in chronic venous leg ulcers (CVLUs). APPROACH: This study used a longitudinal comparative design of 60 serum samples collected from 30 older adult patients with CVLUs, receiving weekly sharp debridement at a wound clinic...
March 21, 2024: Advances in Wound Care
https://read.qxmd.com/read/38511244/utilization-of-broad-versus-narrow-spectrum-antibiotics-for-the-treatment-of-outpatient-community-acquired-pneumonia-among-adults-in-the-united-states
#38
JOURNAL ARTICLE
Katelin B Nickel, Michael J Durkin, Margaret A Olsen, John M Sahrmann, Elizabeth Neuner, Caroline A O'Neil, Anne M Butler
PURPOSE: To characterize antibiotic utilization for outpatient community-acquired pneumonia (CAP) in the United States. METHODS: We conducted a cohort study among adults 18-64 years diagnosed with outpatient CAP and a same-day guideline-recommended oral antibiotic fill in the MarketScan® Commercial Database (2008-2019). We excluded patients coded for chronic lung disease or immunosuppressive disease; recent hospitalization or frequent healthcare exposure (e...
April 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38511216/targeting-osteopontin-alleviates-endometriosis-and-inflammation-by-inhibiting-the-rhoa-ros-axis-and-achieves-non-invasive-in-vitro-detection-via-menstrual-blood
#39
JOURNAL ARTICLE
Han Wang, Binming Wang, Meiling Wu, Jiefang Lu, Ping Duan
STUDY QUESTION: How does osteopontin (OPN) in endometriosis ectopic stromal cells (EESCs) participate in the pathogenesis of endometriosis and achieve non-invasive detection in vitro? SUMMARY ANSWER: Targeted OPN regulates endometriosis's necroptosis and inflammatory state by inhibiting the RhoA/reactive oxygen species (ROS) axis, thereby alleviating endometriosis and enabling non-invasive detection of menstrual blood in vitro. WHAT IS KNOWN ALREADY: Endometriosis is a chronic inflammatory disease...
March 20, 2024: Human Reproduction
https://read.qxmd.com/read/38510559/factors-associated-with-deep-sternal-wound-infection-after-open-heart-surgery-in-a-danish-registry
#40
JOURNAL ARTICLE
Lisa Gundestrup, Christoffer Koch Florczak, Lars Peter Schødt Riber
OBJECTIVE: To conduct a comprehensive multivariate analysis of variables associated with deep sternal wound infection, after open-heart surgery via median sternotomy. METHOD: A retrospective cohort of all adult patients, who underwent open-heart surgery at Odense University Hospital between 01-01-2000 and 31-12-2020 was extracted from the West Danish Heart Registry. Data were analyzed using maximum likelihood logistic regression. RESULTS: A total of 15,424 patients underwent open-heart surgery and 244 developed a deep sternal wound infection, equivalent to 1,58 %...
July 2023: American heart journal plus: cardiology research and practice
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