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https://www.readbyqxmd.com/read/28811680/the-antimicrobial-peptide-human-beta-defensin-3-is-induced-by-platelet-released-growth-factors-in-primary-keratinocytes
#1
Andreas Bayer, Justus Lammel, Mersedeh Tohidnezhad, Sebastian Lippross, Peter Behrendt, Tim Klüter, Thomas Pufe, Jochen Cremer, Holger Jahr, Franziska Rademacher, Regine Gläser, Jürgen Harder
Platelet-released growth factors (PRGF) and its related clinically used formulations (e.g., Vivostat Platelet-Rich Fibrin (PRF®)) contain a variety of chemokines, cytokines, and growth factors and are therefore used to support healing of chronic, hard-to-heal, or infected wounds. Human beta-defensin-3 (hBD-3) is an antimicrobial peptide inducibly expressed in human keratinocytes especially upon wounding. The potent antimicrobial activity of hBD-3 together with its wound closure-promoting activities suggests that hBD-3 may play a crucial role in wound healing...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28811229/necrotizing-fasciitis-following-venomous-snakebites-in-a-tertiary-hospital-of-southwest-taiwan
#2
Yao-Hung Tsai, Wei-Hsiu Hsu, Kuo-Chin Huang, Pei-An Yu, Chi-Lung Chen, Liang Tseng Kuo
BACKGROUND: Necrotizing fasciitis following venomous snakebites is uncommon. The purpose of this study was to describe the initial clinical features of necrotizing fasciitis after snakebites, and to identify the risk factors for patients with cellulitis who later developed necrotizing fasciitis. METHODS: Sixteen patients with surgically-confirmed necrotizing fasciitis and 25 patients diagnosed with cellulitis following snakebites were retrospectively reviewed over a 6-year period...
August 12, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28810878/classification-of-chronic-radiation-induced-ulcers-in-the-chest-wall-after-surgery-in-breast-cancers
#3
Xiao Ma, Zengqiang Jin, Guojun Li, Wenfeng Yang
BACKGROUND AND PURPOSE: To explore the methods of clinical classification in chronic radiation-induced ulcers in the chest wall (CRUCWs). MATERIALS AND METHODS: A total of 64 patients with CRUCWs were treated. We divided the cases into 3 types (mild, moderate, or severe) according to their clinical manifestations. Conservative treatments, axial-pattern myocutaneous or local flaps, or filleted flaps were applied correspondingly. RESULTS: The cases were divided as follows: mild (n = 11), moderate (n = 45), and severe (n = 8)...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28810801/may-dietary-supplementation-augment-respiratory-burst-in-wound-site-inflammatory-cells
#4
Amitava Das, Ryan Dickerson, Piya Das Ghatak, Gayle Gordillo, Scott Chaffee, Abhijoy Saha, Savita Khanna, Sashwati Roy
Persistent infection contributes to wound chronicity. At the wound-site, NADPH oxidase activity in immune cells fights infection to enable the healing process. Fermented Papaya Preparation (FPP) is a carbohydrate-rich nutritional supplement that has demonstrated ability to bolster respiratory burst in experimental rodent systems. In FPP, glucose co-exists with fructose and maltose in addition to multiple other sugar alcohols such as inositol. We have previously reported that FPP supplementation augments wound healing in diabetic mice via improvement of respiratory-burst activity of wound innate immune cells...
August 16, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28810449/the-importance-of-relationships-in-treatment-for-chronic-leg-ulceration
#5
Philippa Tollow, Jane Ogden
Leg ulcers are a hard-to-heal wound that can have a profound impact on the lives of those that they affect. While a significant body of evidence has explored the efficacy of various treatments for leg ulcers, little research has addressed the patient experience of such treatment. A total of 21 participants were recruited for this qualitative interview study, exploring patient's experiences of non-surgical treatment for leg ulcers. Thematic analysis identified two major themes, 'Failure' and 'Powerlessness', as well as the overarching theme of 'Relationships'...
May 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28808517/the-mythos-of-laudable-pus-along-with-an-explanation-for-its-origin
#6
Jeffrey A Freiberg
The presence of pus is one of the most easily recognizable signs of an infection. However, for several centuries suppuration, known as 'laudable pus,' was believed to be a sign of a healthy, healing wound. This historical misconception can be explained by the difference in the presentation of a necrotizing soft tissue infection versus other more common skin and soft tissue infections. Chronic wound infections, due to pyogenic bacteria, typically produce large amounts of thick, whitish-yellow pus. On the other hand, necrotizing soft tissue infections, despite their severe mortality and morbidity, are devoid of pus in the traditional sense...
July 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28808357/platelet-released-growth-factors-induce-differentiation-of-primary-keratinocytes
#7
Andreas Bayer, Mersedeh Tohidnezhad, Justus Lammel, Sebastian Lippross, Peter Behrendt, Tim Klüter, Thomas Pufe, Holger Jahr, Jochen Cremer, Franziska Rademacher, Regine Gläser, Jürgen Harder
Autologous thrombocyte concentrate lysates, for example, platelet-released growth factors, (PRGFs) or their clinically related formulations (e.g., Vivostat PRF®) came recently into the physicians' focus as they revealed promising effects in regenerative and reparative medicine such as the support of healing of chronic wounds. To elucidate the underlying mechanisms, we analyzed the influence of PRGF and Vivostat PRF on human keratinocyte differentiation in vitro and on epidermal differentiation status of skin wounds in vivo...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28807880/-broad-spectrum-bactericidal-activity-of-a-new-bioactive-grafting-material-f18-against-clinically-important-bacterial-strains
#8
M T Souza, L A Campanini, C R Chinaglia, O Peitl, E D Zanotto, C W O Souza
Infection is the most relevant surgical complication in implant or grafting procedures. Osteomyelitis and other chronic conditions pose a constant challenge in the current practice of medicine. In this context, a grafting biomaterial that possesses antibacterial properties combined with bioactivity could have great clinical impact. Researchers at the Vitreous Materials Laboratory (LaMaV-UFSCar) recently developed a glass composition, F18, which presents an improved workability range combined with high bioactivity...
August 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28807848/hydroalcoholic-extract-from-bark-of-persea-major-meisn-l-e-kopp-lauraceae-exerts-antiulcer-effects-in-rodents-by-the-strengthening-of-the-gastric-protective-factors
#9
Lincon Bordignon Somensi, Thaise Boeing, Benhur Judah Cury, Viviane Miranda Bispo Steimbach, Rivaldo Niero, Lauro Mera de Souza, Luisa Mota da Silva, Sérgio Faloni de Andrade
ETHOPHARMACOLOGICAL RELEVANCE: The Persea major (Meisn.) L.E. Kopp (Lauraceae) (botanical synonym: Persea pyrifolia (D. Don) Spreng, Persea pyrifolia Nees and Mart., Persea cordata var. major (Meisn.) Mez and Persea willdenovii Kosterm) is a medicinal plant native in the south of Brazil, where is popularly known as Pau de Andrade, Maçaranduba or Abacate-do-Mato. Its barks are commonly used to prepare an infusion which is administered orally or topically to treat ulcers and wounds, respectively...
August 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28807666/microrna-132-with-therapeutic-potential-in-chronic-wounds
#10
Xi Li, Dongqing Li, Aoxue Wang, Tongbin Chu, Warangkana Lohcharoenkal, Xiaowei Zheng, Jacob Grünler, Sampath Narayanan, Sofie Eliasson, Eva K Herter, Yang Wang, Yannan Ma, Marcus Ehrström, Liv Eidsmo, Maria Kasper, Andor Pivarcsi, Enikö Sonkoly, Sergiu-Bogdan Catrina, Mona Ståhle, Ning Xu Landén
Chronic wounds represent a major and rising health and economic burden worldwide. There is a continued search towards more effective wound therapy. We found significantly reduced microRNA-132 (miR-132) expression in human diabetic ulcers compared to normal skin wounds, and also in skin wounds of leptin receptor-deficient (db/db) diabetic mice compared to wild-type mice. Local replenishment of miR-132 in the wounds of db/db mice accelerated wound closure effectively, which was accompanied by increased proliferation of wound-edge keratinocytes and reduced inflammation...
August 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28807206/graft-loss-review-of-a-single-burn-center-s-experience-and-proposal-of-a-graft-loss-grading-scale
#11
Lauren B Nosanov, Melissa M McLawhorn, Lamisa Hassan, Taryn E Travis, Shawn Tejiram, Laura S Johnson, Lauren T Moffatt, Jeffrey W Shupp
BACKGROUND: There exists neither a consensus definition of burn "graft loss" nor a scale with which to grade severity. We introduced an institutional scale in 2014 for quality improvement. MATERIALS AND METHODS: We reviewed all burned patients with graft loss on departmental Morbidity and Mortality reports between July 2014 and July 2016. Graft loss grades were assigned during the course of clinical care per institutional scale. Chronic nonhealing wounds and nonburn wounds were excluded...
August 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28805478/production-of-platelet-rich-plasma-gel-from-elderly-patients-under-antithrombotic-drugs-perspectives-in-chronic-wounds-care
#12
M Velier, J Magalon, A Daumas, M Cassar, P Francois, A Ghazouane, C Philandrianos, B Bertrand, C Frere, D Bernot, P Villani, F Dignat George, F Sabatier
Platelet-Rich Plasma (PRP) is an autologous biological therapy obtained by centrifuging the patient's own blood to concentrate platelets. The addition of autologous thrombin and calcium chloride to PRP allows the production of a semi-solid form called PRP gel. PRP gel is increasingly used in a variety of tissue defects and predominantly in the management of non-healing chronic wounds. The topical application of PRP gel seems promising due to the capability of platelets to store and secrete growth factors (GF), fibrin and cytokines, which are essentials for wound healing...
August 14, 2017: Platelets
https://www.readbyqxmd.com/read/28801610/creb3l2-mediated-expression-of-sec23a-sec24d-is-involved-in-hepatic-stellate-cell-activation-through-er-golgi-transport
#13
Shotaro Tomoishi, Shinichi Fukushima, Kentaro Shinohara, Toshiaki Katada, Kota Saito
Hepatic fibrosis is caused by exaggerated wound healing response to chronic injury, which eventually leads to hepatic cirrhosis. Differentiation of hepatic stellate cells (HSCs) to myofibroblast-like cells by inflammatory cytokines is the critical step in fibrosis. This step is accompanied by enlargement of the endoplasmic reticulum (ER) and Golgi apparatus, suggesting that protein synthesis and secretion are augmented in the activated HSCs. However, the process of rearrangement of secretory organelles and their functions remain to be fully elucidated...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801009/management-of-radiation-side-effects-to-the-skin
#14
REVIEW
Tracy Gieger, Michael Nolan
Radiation therapy (RT) is an essential component for management of many cancers. Veterinary health care professionals must counsel owners about the potential side effects of RT, the anticipated management plan, and associated costs. For most veterinary patients treated with RT, acute radiation side effects are mild; however, careful radiation treatment planning and appropriate management of acute side effects are essential to try to prevent chronic sequelae and the need for ongoing wound care. This article reviews acute and late side effects to the skin and their management...
August 9, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28798504/molecular-aspects-of-wound-healing-and-the-rise-of-venous-leg-ulceration-omics-approaches-to-enhance-knowledge-and-aid-diagnostic-discovery
#15
REVIEW
Daniel A Broszczak, Elizabeth R Sydes, Daniel Wallace, Tony J Parker
Chronic wounds, in particular venous leg ulcers (VLU), represent a substantial burden for economies, healthcare systems and societies worldwide. This burden is exacerbated by the recalcitrant nature of these wounds, despite best practice, evidence-based care, which substantially reduces the quality of life of patients. Furthermore, co-morbidities such as diabetes and cardiovascular disease within ageing populations further contribute to the increasing prevalence in developed countries. This review provides an overview of the literature concerning the cellular and molecular mechanisms of wound healing and aspects where this process fails, resulting in a chronic wound...
February 2017: Clinical Biochemist. Reviews
https://www.readbyqxmd.com/read/28797647/matrix-metalloproteinases-the-sculptors-of-chronic-cutaneous-wounds
#16
REVIEW
Venkat Raghavan Krishnaswamy, Dvir Mintz, Irit Sagi
Cutaneous wound healing is a complex mechanism with multiple processes orchestrating harmoniously for structural and functional restoration of the damaged tissue. Chronic non-healing wounds plagued with infection create a major healthcare burden and is one of the most frustrating clinical problems. Chronic wounds are manifested by prolonged inflammation, defective re-epithelialization and haphazard remodeling. Matrix metalloproteinases (MMPs) are zinc dependent enzymes that play cardinal functions in wound healing...
August 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28795892/cold-atmospheric-pressure-plasma-for-treatment-of-chronic-wounds-drug-or-medical-device
#17
A Kramer, B R Conway, K Meissner, F Scholz, B H Rauch, A Moroder, A Ehlers, A J Meixner, C-D Heidecke, L I Partecke, M Kietzmann, O Assadian
OBJECTIVE: The use of cold atmospheric pressure plasma (CAPP) as a new therapeutic option to aid the healing of chronic wounds appears promising. Currently, uncertainty exists regarding their classification as medical device or medical drug. Because the classification of CAPP has medical, legal, and economic consequences as well as implications for the level of preclinical and clinical testing, the correct classification is not an academic exercise, but an ethical need. METHOD: A multidisciplinary team of physicians, surgeons, pharmacists, physicists and lawyers has analysed the physical and technical characteristics as well as legal conditions of the biological action of CAPP...
August 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28795891/experience-using-closed-incision-negative-pressure-wound-therapy-in-sternotomy-patients
#18
B Philip, P McCluskey, J Hinchion
OBJECTIVE: Postoperative delayed wound healing, surgical site infections (SSIs), and other wound complications are associated with increased morbidity and health-care costs. In cardiothoracic surgery, wound complications can have life-threatening consequences. In recent years, negative pressure wound therapy (NPWT) has been applied over closed surgical incisions to help reduce tension and protect from external contamination. We report our initial experiences using a closed incision negative pressure therapy (ciNPT) over clean, closed sternotomy incisions at an Irish tertiary referral centre...
August 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28795890/point-of-care-fluorescence-imaging-predicts-the-presence-of-pathogenic-bacteria-in-wounds-a-clinical-study
#19
M Y Rennie, L Lindvere-Teene, K Tapang, R Linden
OBJECTIVE: Bacteria in chronic wounds are invisible to the naked eye and can lead to delayed wound healing. Point-of-care bacterial fluorescence imaging illuminates a wound with 405nm light, triggering bacteria to produce red fluorescence and enabling real-time bacterial localisation. Prospective, single-blind clinical trials (clinicaltrials.gov #NCT02682069, #NCT03091361) were conducted to determine the positive predictive value (PPV) of this red fluorescence for detecting bacteria in chronic wounds...
August 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28795889/use-of-an-engineered-honey-to-eradicate-preformed-biofilms-of-important-wound-pathogens-an-in-vitro-study
#20
F D Halstead, M A Webber, B A Oppenheim
OBJECTIVE: We previously reported on the ability of SurgihoneyRO (SHRO), an engineered honey, to prevent biofilm formation in vitro, but data were lacking regarding the activity against preformed biofilms. This study aims to assess whether SHRO has any antibacterial activity against mature, preformed biofilms and whether there is any evidence to support the observed clinical effectiveness when SHRO has been used anecdotally on acute and chronic wounds where biofilm is most likely present...
August 2, 2017: Journal of Wound Care
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