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Chronic wounds

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https://www.readbyqxmd.com/read/28723141/disperse-and-collect-approach-for-the-type-selective-detection-of-matrix-metalloproteinases-in-porous-silicon-resonant-microcavities
#1
Fransiska S H Krismastuti, Melissa R Dewi, Beatriz Prieto-Simon, Thomas Nann, Nicolas H Voelcker
We report on the design and testing of photonic biosensors for the type-selective detection of different types of matrix metalloproteinases (MMPs). The ability to detect a panel of different MMP types has important implications for prognosis of wound healing. We combine the immunocapture of MMPs on dispersed magnetic nanoparticles modified with antibodies specific for target MMPs (immuno-magNPs) with subsequent MMP detection upon fluorogenic peptide cleavage in porous silicon resonant microcavity (pSiRM) architectures...
February 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722595/multidrug-resistant-microorganisms-colonizing-lower-extremity-wounds-in-patients-in-a-tertiary-care-hospital-lima-peru
#2
Rafael Mendo-Lopez, Luis Jasso, Ximena Guevara, Aurora Lizeth Astocondor, Saul Alejos, Ana C Bardossy, Tyler Prentiss, Marcus J Zervos, Jan Jacobs, Coralith García
Multidrug-resistant organism (MDRO) infections cause high morbidity and mortality, and high costs to patients and hospitals. The study aims were to determine the frequency of MDRO colonization and associated factors in patients with lower-extremity wounds with colonization. A cross-sectional study was designed during November 2015 to July 2016 in a tertiary care hospital in Lima, Peru. A wound swab was obtained for culture and susceptibility testing. MDRO colonization was defined if the culture grew with methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and/or extended spectrum beta-lactamase (ESBL) microorganisms...
June 19, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28714933/macrophage-phenotypes-regulate-scar-formation-and-chronic-wound-healing
#3
REVIEW
Mark Hesketh, Katherine B Sahin, Zoe E West, Rachael Z Murray
Macrophages and inflammation play a beneficial role during wound repair with macrophages regulating a wide range of processes, such as removal of dead cells, debris and pathogens, through to extracellular matrix deposition re-vascularisation and wound re-epithelialisation. To perform this range of functions, these cells develop distinct phenotypes over the course of wound healing. They can present with a pro-inflammatory M1 phenotype, more often found in the early stages of repair, through to anti-inflammatory M2 phenotypes that are pro-repair in the latter stages of wound healing...
July 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28713711/the-role-of-human-adult-peripheral-and-umbilical-cord-blood-platelet-rich-plasma-on-proliferation-and-migration-of-human-skin-fibroblasts
#4
Seyedeh-Sara Hashemi, Mahdokht Mahmoodi, Ali Reza Rafati, Farzad Manafi, Davood Mehrabani
BACKGROUND: Wound healing is a complex and dynamic process following damage in tissue structures. Due to extensive skin damage caused by burn injuries, this study determined the role of human adult peripheral and umbilical cord blood platelet-rich plasma on proliferation and migration in human skin fibroblasts. METHODS: Platelet-rich plasma (5, 10, 15, 20 and 50% PRP) from human umbilical cord blood and adult peripheral blood were provided and added to fibroblasts cultured from a human skin sample...
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28713016/a-conducive-bioceramic-polymer-composite-biomaterial-for-diabetic-wound-healing
#5
Fang Lv, Jie Wang, Peng Xu, Yiming Han, Hongshi Ma, He Xu, Shijie Chen, Jiang Chang, Qinfei Ke, Mingyao Liu, Zhengfang Yi, Chengtie Wu
Diabetic wound is a common complication of diabetes. Biomaterials offer great promise in inducing tissue regeneration for chronic wound healing. Herein, we reported a conducive Poly (caprolactone) (PCL)/gelatin nanofibrous composite scaffold containing silicate-based bioceramic particles (Nagelschmidtite, NAGEL, Ca7P2Si2O16) for diabetic wound healing. NAGEL bioceramic particles were well distributed in the inner of PCL/gelatin nanofibers via co-electrospinning process and the Si ions maintained a sustained release from the composite scaffolds during the degradation process...
July 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28712679/the-molecular-biology-in-wound-healing-non-healing-wound
#6
REVIEW
Chun Qing
The development of molecular biology and other new biotechnologies helps us to recognize the wound healing and non-healing wound of skin in the past 30 years. This review mainly focuses on the molecular biology of many cytokines (including growth factors) and other molecular factors such as extracellular matrix (ECM) on wound healing. The molecular biology in cell movement such as epidermal cells in wound healing was also discussed. Moreover many common chronic wounds such as pressure ulcers, leg ulcers, diabetic foot wounds, venous stasis ulcers, etc...
June 30, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28711364/curcumin-and-its-topical-formulations-for-wound-healing-applications
#7
REVIEW
Chandana Mohanty, Sanjeeb K Sahoo
Oxidative damage and inflammation have been identified, through clinical and preclinical studies, as the main causes of nonhealing chronic wounds. Reduction of persistent chronic inflammation by application of antioxidant and anti-inflammatory agents such as curcumin has been well studied. However, low aqueous solubility, poor tissue absorption, rapid metabolism and short plasma half-life have made curcumin unsuitable for systemic administration for better wound healing. Recently, various topical formulations of curcumin such as films, fibers, emulsion, hydrogels and different nanoformulations have been developed for targeted delivery of curcumin at wounded sites...
July 12, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28711023/gingival-crevicular-fluid-and-plasma-oxidative-stress-markers-and-tgm-2-levels-in-chronic-periodontitis
#8
Sema Becerik, Veli Özgen Öztürk, Peter Celec, Natalia Kamodyova, Gül Atilla, Gülnur Emingil
OBJECTIVE: This study was aimed to evaluate the gingival crevicular fluid (GCF) and plasma transglutaminase-2 (TGM-2), total antioxidant capacity (TAC), total oxidant status (TOS), ferric reducing antioxidant power (FRAP) and thiobarbituric acid reactive substances (TBARS) in patients with chronic periodontal disease. MATERIALS AND METHODS: Twenty patients with chronic periodontitis (CP), 20 patients with gingivitis and 20 healthy subjects were enrolled in the study...
June 29, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28707450/a-simple-concept-for-covering-pressure-sores-wound-edge-based-propeller-perforator-flap
#9
Osman Kelahmetoglu, Koenraad Van Landuyt, Caglayan Yagmur, Casper E Sommeling, Musa K Keles, Volkan Tayfur, Tekin Simsek, Yener Demirtas, Ethem Guneren
We present a new surgical modification to allow propeller perforator flaps to cover pressure sores at various locations. We used a propeller perforator flap concept based on the detection of newly formed perforator vessels located 1 cm from the wound margin and stimulated by the chronic inflammation process. Between January 2009 and January 2017, 33 wound edge-based propeller perforator flaps were used to cover pressure sores at various locations in 28 patients. In four cases more than one flap was used on the same patient...
July 13, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28706515/more-pathogenicity-or-just-more-pathogens-on-the-interpretation-problem-of-multiple-pathogen-detections-with-diagnostic-multiplex-assays
#10
REVIEW
Andreas E Zautner, Uwe Groß, Matthias F Emele, Ralf M Hagen, Hagen Frickmann
Modern molecular diagnostic approaches in the diagnostic microbiological laboratory like real-time quantitative polymerase chain reaction (qPCR) have led to a considerable increase of diagnostic sensitivity. They usually outperform the diagnostic sensitivity of culture-based approaches. Culture-based diagnostics were found to be insufficiently sensitive for the assessment of the composition of biofilms in chronic wounds and poorly standardized for screenings for enteric colonization with multi-drug resistant bacteria...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28705624/evaluation-of-three-layered-doxycycline-collagen-loaded-nanofiber-wound-dressing
#11
Tort Serdar, Acartürk Füsun, Beşikci Arzu
Nanofiber wound dressings have great potential for both acute and chronic wound healing. The aim of this study is to develop a wound dressing by the electrospinning method and to determine its in vitro characteristics. The viscosity and the surface tension values of the polymer solutions used in the electrospinning were measured and their suitability for electrospinning was evaluated. Nanofiber wound dressing consists of three layers. The core of the coaxial nanofibers that comprises the first layer of the wound dressing contains 1% polycaprolactone and 4...
July 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28704171/a-bioluminescent-pseudomonas-aeruginosa-wound-model-reveals-increased-mortality-of-type-1-diabetic-mice-to-biofilm-infection
#12
Agostinho Hunt A M, Gibson J A, Larrivee C L, O'Reilly S, Navitskaya S, Needle D B, Abramovitch R B, Busik J V, Waters C M
OBJECTIVE: To examine how bacterial biofilms, as contributing factors in the delayed closure of chronic wounds in patients with diabetes, affect the healing process. METHOD: We used daily microscopic imaging and the IVIS Spectrum in vivo imaging system to monitor biofilm infections of bioluminescent Pseudomonas aeruginosa and evaluate healing in non-diabetic and streptozotocin-induced diabetic mice. RESULTS: Our studies determined that diabetes alone did not affect the rate of healing of full-depth murine back wounds compared with non-diabetic mice...
July 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28704169/patients-and-clinicians-experiences-of-wound-care-in-canada-a-descriptive-qualitative-study
#13
Woo K Y, Wong J, Rice K, Coelho S, Haratsidis E, Teague L, Rac V E, Krahn M
OBJECTIVE: This study sought to explore patients' and clinicians' perceptions and experiences with the provision of standard care by a home care nurse alone or by a multidisciplinary wound care team. METHOD: The interviews were conducted using an in-depth semi structured format; following a funnel idea of starting out broad and narrowing down, ensuring that all the necessary topics were covered by the end of the interview. RESULTS: A purposive sample of 16 patients with different wound types were interviewed to ensure that the data would reflect the range and diversity of treatment and care experience...
July 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28704156/quality-of-life-in-patients-with-leg-ulcers-results-from-challenge-a-double-blind-randomised-controlled-trial
#14
S Meaume, A Dompmartin, C Lok, I Lazareth, M Sigal, F Truchetet, A Sauvadet, S Bohbot
OBJECTIVE: We recently showed the superiority of a matrix metalloproteinase (MMP) modulating dressing (foam impregnated with NOSF, nano-oligosaccharide factor) compared with a lipidocolloid matrix (TLC) control dressing in median wound area reduction (WAR). Here we report the results from the same study assessing the performance and safety of TLC-NOSF in the local management of venous leg ulcers (VLUs) or mixed leg ulcers and determining its impact on the patient's health-related quality of life (HRQoL)...
July 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28704149/amputation-predictors-in-diabetic-foot-ulcers-treated-with-hyperbaric-oxygen
#15
S T Kaplan, D Hemsinli, S Kaplan, A Arslan
OBJECTIVE: Although hyperbaric oxygen therapy (HBOT) has long been used for diabetic foot ulcers (DFUs), its effectiveness is still controversial. The aim of this study was to investigate the efficacy of HBOT in the management of DFUs and identify amputation predictors. METHOD: Patients with chronic DFUs (Wanger grade 2-5) were included in the study, which took place between January 2010 and December 2012. HBOT, 100% oxygen, 2.4 atmosphere absolute (ATA) for 120 minutes, was administered to all patients in addition to standard treatment...
July 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28702985/photobiomodulation-with-polarized-light-in-the-treatment-of-cutaneous-and-mucosal-ulcerative-lesions
#16
S E Aragona, F R Grassi, G Nardi, J Lotti, G Mereghetti, E Canavesi, E Equizi, A M Puccio, G Gianazza, T Lotti, I Morisi
In recent decades, regenerative medicine has achieved an important evolution at both a conceptual level and scientific production, which explains the current and future possibilities of therapy and daily clinical practice. The main aim of regenerative medicine is the complex system of repair/regeneration. The current literature on the subject demonstrates the advantage of visible light therapy for skin injuries and diseases with the photobiomodulation in which light at low energy levels modulates intra- and extra-cellular photoreceptors by molecular and cellular processes that can stimulate both anti-inflammatory mechanisms and cell proliferative response...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702983/photobiomodulation-in-the-treatment-of-chronic-non-responding-wounds
#17
S E Aragona, G Mereghetti, G Gianazza, E Equizi, J Lotti, T Lotti, G V L Colombo
We present a protocol of care and therapeutic approach to skin lesions, called AIMED (Anti Inflammatory Regenerative Medicine), which is based on the circularity of its phases and applied therapeutic methodologies. We used photobiomodulation (PBM) for the examination non-responding skin lesions. PBM is an adjuvant treatment for the stimulation of regenerative cellular processes, reduction of inflammation and pain and biochemical modulation of molecular response. We used PBM for the examination of skin lesions, which were not responding to other therapies...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702902/oxygenation-status-in-chronic-leg-ulcer-after-topical-hemoglobin-application-may-act-as-a-surrogate-marker-to-find-the-best-treatment-strategy-and-to-avoid-ineffective-conservative-long-term-therapy
#18
Maximilian Petri, Ingo Stoffels, Klaus Griewank, Jithin Jose, Peter Engels, Andrea Schulz, Harald Pötzschke, Philipp Jansen, Dirk Schadendorf, Joachim Dissemond, Joachim Klode
PURPOSE: Chronic leg ulcers can be a challenge to treat and long-term therapy a significant cost factor in western public health budgets. Objective wound assessment assays enabling selection of appropriate wound therapy regimes would be desirable. Oxygenation status in ulcer tissue has obtained increased attention as a relevant factor in wound healing. To increase oxygenation in wounds, a topical hemoglobin spray was developed. Although favorable results have been noted, the link between clinical efficacy and the mode of action has not been demonstrated...
July 12, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28702186/the-biological-and-clinical-basis-for-the-use-of-adipose-derived-stem-cells-in-the-field-of-wound-healing
#19
REVIEW
Nicolò Bertozzi, Francesco Simonacci, Michele Pio Grieco, Eugenio Grignaffini, Edoardo Raposio
Worldwide, hard-to-heal lower limb wounds are estimated to affect 1.5-3% of the adult population with a treatment-related annual cost of $10 billion. Thus, chronic skin ulcers of the lower limb are a matter of economic and public concern. Over the years, multiple medical and surgical approaches have been proposed but they are still inadequate, and no effective therapy yet exists. Regenerative medicine and stem cell-based therapies hold great promise for wound healing. Recently, many plastic surgeons have studied the potential clinical application of adipose-derived stem cells (ASCs), which are a readily available adult stem cell population that can undergo multilineage differentiation and secrete growth factors that can enhance wound-healing processes by promoting angiogenesis, and hence increase local blood supply...
August 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28699502/chronic-wounds-innovations-in-diagnostics-and-therapeutics
#20
Marieke Haalboom
One of the major global health issues is the existence of chronic wounds. Chronic wounds are wounds that show a delayed, or even failed, healing process. The healing process often stagnates in the inflammatory phase or proliferative phase. Since traditional treatment methods have shown to be of limited effectiveness in chronic wound care, the focus has shifted to increase the knowledge of the wound healing process and the deficiencies encountered in chronic wounds. This increased knowledge has provided the opportunity for development of new diagnostics and therapeutics in chronic wound care that detect and treat specific deficiencies instead of one common treatment for all chronic wounds...
July 10, 2017: Current Medicinal Chemistry
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