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Chronic wounds

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https://www.readbyqxmd.com/read/28923218/randomized-controlled-trials-in-soft-tissue-sarcoma-we-are-getting-there
#1
REVIEW
Andrea J MacNeill, Abha Gupta, Carol J Swallow
Soft tissue sarcoma (STS) is a family of malignancies for which individual management decisions can be complex. There is a paucity of level 1 evidence, as the rarity and heterogeneity of STS pose challenges to the design and execution of randomized controlled trials. Radiotherapy (RT) is routinely used to facilitate function-preserving surgery and to improve local control. Delivery of RT in the preoperative setting can decrease chronic toxicities at the cost of increased wound complications in the short-term...
October 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28922523/mature-b-cells-accelerate-wound-healing-after-acute-and-chronic-diabetic-skin-lesions
#2
Ruxandra F Sîrbulescu, Chloe K Boehm, Erin Soon, Moses Q Wilks, Iulian Ilieş, Hushan Yuan, Ben Maxner, Nicolas Chronos, Charalambos Kaittanis, Marc D Normandin, Georges El Fakhri, Dennis P Orgill, Ann E Sluder, Mark C Poznansky
Chronic wounds affect 12-15% of patients with diabetes and are associated with a drastic decrease in their quality of life. Here we demonstrate that purified mature naïve B220(+) /CD19(+) /IgM(+) /IgD(+) B cells improve healing of acute and diabetic murine wounds after a single topical application. B cell treatment significantly accelerated acute wound closure by 2-3 days in wild-type mice and 5-6 days in obese diabetic mice. The treatment led to full closure in 43% of chronic diabetic wounds, as compared to only 5% in saline-treated controls...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28922511/reliability-and-measurement-error-of-digital-planimetry-for-the-measurement-of-chronic-venous-leg-ulcers
#3
Michael Stacey, Steven Phillips, Forough Farrokhyar, Jillian M Swaine
Area measurements of a chronic wound are the gold standard outcome measure to determine if a wound is on a healing or non-healing trajectory. The use of digital planimetry can provide increased accuracy in measuring wound area however it is important to know the reliability and measurement error of these devices when used by multiple assessors. The aim of this study is to determine the within rater, between rater, and standard error of measurement of a digital planimetry device. Wound area in 42 patients was measured weekly for 12 weeks by two different raters, with each rater measuring the wound 10 times per visit...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28918770/the-forgotten-need-of-disaster-relief
#4
Leonardo Tamariz, Cynthia Cely, Ana Palacio
Disasters in countries with limited resources can put the emergency preparedness of the country to the test. The first major task after a disaster is to take care of the wounded. In countries where the epidemiological transition has occurred, chronic disease can place a major strain on public health preparedness after a disaster. The purpose of this field report is to alert public health practitioners of an infrequently reported public health problem: the impact of natural disasters on adherence to chronic medications...
September 18, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28918046/microrna-as-therapeutic-targets-for-chronic-wound-healing
#5
REVIEW
Eoghan J Mulholland, Nicholas Dunne, Helen O McCarthy
Wound healing is a highly complex biological process composed of three overlapping phases: inflammation, proliferation, and remodeling. Impairments at any one or more of these stages can lead to compromised healing. MicroRNAs (miRs) are non-coding RNAs that act as post-transcriptional regulators of multiple proteins and associated pathways. Thus, identification of the appropriate miR involved in the different phases of wound healing could reveal an effective third-generation genetic therapy in chronic wound care...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28914838/-native-collagen-application-in-clinical-practice-for-chronic-wounds-treatment
#6
E V Silina, V A Stupin, L S Zolotareva, A N Komarov
No abstract text is available yet for this article.
2017: Khirurgiia
https://www.readbyqxmd.com/read/28914827/-endovascular-surgery-for-critical-ischemia-of-lower-extremities-with-suppurative-necrotic-lesion-of-the-feet
#7
K V Lipatov, S V Permyakov, A G Asatryan, A V Borodin, V K Gostishchev
AIM: To improve treatment of patients with grade IV chronic ischemia of lower extremities via endovascular angioplasty combined with surgical methods for suppurative-necrotic lesions of the feet. MATERIAL AND METHODS: 51 patients with grade IV chronic ischemia of lower extremities underwent endovascular interventions (balloon angioplasty, stenting). A total of 23 stents were deployed in 16 patients including 12 stents in superficial and common femoral arteries, 5 in popliteal artery, 6 in iliac artery...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28914685/update-topical-antimicrobial-agents-for-chronic-wounds
#8
(no author information available yet)
No abstract text is available yet for this article.
October 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28914682/refractory-ulcerated-necrobiosis-lipoidica-closure-of-a-difficult-wound-with-topical-tacrolimus
#9
Luke Ginocchio, Lisa Draghi, Farbod Darvishian, Frank L Ross
OBJECTIVE: To report a case of refractory ulcerated necrobiosis lipoidica (NL) with significant response to treatment with topical tacrolimus. SUBJECT: A 55-year-old woman without diabetes and with a previous history of NL presented to the Helen L. and Martin S. Kimmel Hyperbaric and Advanced Wound Healing Center of NYU Langone Medical Center, New York, with bilateral lower-leg ulcerations resistant to wound healing techniques at other institutions. MATERIALS AND METHODS: Repeat biopsy performed at the author's institution confirmed the diagnosis of NL...
October 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28914678/update-topical-antimicrobial-agents-for-chronic-wounds
#10
R Gary Sibbald, James A Elliott, Luvneed Verma, Alisa Brandon, Reneeka Persaud, Elizabeth A Ayello
GENERAL PURPOSE: To provide information on the use of topical antimicrobial agents for the treatment of chronic wounds. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After participating in this educational activity, the participant should be better able to:1. Examine features of wounds and wound healing as well as the purpose of specific antimicrobial agents...
October 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28904951/diabetic-foot-ulcers-and-epidermal-growth-factor-revisiting-the-local-delivery-route-for-a-successful-outcome
#11
REVIEW
Jorge Berlanga-Acosta, José Fernández-Montequín, Calixto Valdés-Pérez, William Savigne-Gutiérrez, Yssel Mendoza-Marí, Ariana García-Ojalvo, Viviana Falcón-Cama, Diana García Del Barco-Herrera, Maday Fernández-Mayola, Héctor Pérez-Saad, Eulogio Pimentel-Vázquez, Aleida Urquiza-Rodríguez, Moshe Kulikovsky, Gerardo Guillén-Nieto
Soon after epidermal growth factor (EGF) discovery, some in vivo models appeared demonstrating its property to enhance cutaneous wound healing. EGF was the first growth factor (GF) introduced in the clinical arena as a healing enhancer, exerting its mitogenic effects on epithelial, fibroblastoid, and endothelial cells via a tyrosine kinase membrane receptor. Compelling evidences from the 90s documented that, for EGF, locally prolonged bioavailability and hourly interaction with the receptor were necessary for a successful tissue response...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28904532/the-use-of-adipose-derived-stem-cells-in-selected-skin-diseases-vitiligo-alopecia-and-nonhealing-wounds
#12
REVIEW
Agnieszka Owczarczyk-Saczonek, Anna Wociór, Waldemar Placek, Wojciech Maksymowicz, Joanna Wojtkiewicz
The promising results derived from the use of adipose-derived stem cells (ADSCs) in many diseases are a subject of observation in preclinical studies. ADSCs seem to be the ideal cell population for the use in regenerative medicine due to their easy isolation, nonimmunogenic properties, multipotential nature, possibilities for differentiation into various cell lines, and potential for angiogenesis. This article reviews the current data on the use of ADSCs in the treatment of vitiligo, various types of hair loss, and the healing of chronic wounds...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28902290/effect-of-secondary-infection-on-epithelialisation-and-total-healing-of-cutaneous-leishmaniasis-lesions
#13
Liliane de Fátima Antonio, Marcelo Rosandiski Lyra, Maurício Naoto Saheki, Armando de Oliveira Schubach, Luciana de Freitas Campos Miranda, Maria de Fátima Madeira, Maria Cristina da Silva Lourenço, Aline Fagundes, Érica Aparecida Dos Santos Ribeiro, Leonardo Barreto, Maria Inês Fernandes Pimentel
BACKGROUND: Cutaneous leishmaniasis (CL) generally presents with a single or several localised cutaneous ulcers without involvement of mucous membranes. Ulcerated lesions are susceptible to secondary contamination that may slow the healing process. OBJECTIVE: This study verified the influence of non-parasitic wound infection on wound closure (epithelialisation) and total healing. METHODS: Twenty-five patients with a confirmed diagnosis of CL and ulcerated lesions underwent biopsy of ulcer borders...
September 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28900830/transhiatal-vs-transthoracic-esophagectomy-a-nsqip-analysis-of-postoperative-outcomes-and-risk-factors-for-morbidity
#14
Francisco Schlottmann, Paula D Strassle, Marco G Patti
BACKGROUND: Both transhiatal esophagectomy (THE) and transthoracic esophagectomy (TTE) are accepted procedures for esophageal resection. We aimed to compare postoperative outcomes between these procedures and identify risk factors for morbidity. METHODS: A retrospective analysis was performed using the American College of Surgeons National Surgical Quality Improvement Program database. Adult patients who underwent THE or TTE between 2005 and 2014 were included. Postoperative morbidity, length of stay, and 30-day mortality were compared...
September 12, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28899369/nursing-care-needs-and-services-utilised-by-home-dwelling-elderly-with-complex-health-problems-observational-study
#15
Gro Næss, Marit Kirkevold, Wenche Hammer, Jørund Straand, Torgeir Bruun Wyller
BACKGROUND: In Norway, as in many Western countries, a shift from institutional care to home care is taking place. Our knowledge is limited regarding which needs for nursing interventions patients being cared for in their home have, and how they are met. We aimed at assessing aspects of health and function in a representative sample of the most vulnerable home-dwelling elderly, to identify their needs for nursing interventions and how these needs were met. METHODS: In this observational study we included patients aged 75+ living in their own homes in Oslo, who received daily home care, had three or more chronic diagnoses, received daily medication, and had been hospitalized during the last year...
September 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28895073/efficacy-and-time-sensitivity-of-amniotic-membrane-treatment-in-patients-with-diabetic-foot-ulcers-a-systematic-review-and-meta-analysis
#16
REVIEW
Irakoze Laurent, Manirakiza Astère, Kan Ran Wang, Qing-Feng Cheng, Qi Fu Li
INTRODUCTION: Diabetic foot ulcers (DFUs) are complex chronic wounds which have a major long-term impact on the morbidity, mortality and quality of patients. The objective of this study was to assess the efficacy and time sensitivity of human amnion/chorion membrane treatment in patients with chronic DFUs. METHODS: The Cochrane Library, PubMed, Embase and Web of Science databases were systematically searched to identify relevant articles up to 10 April 2017. All randomized controlled trials (RCTs) comparing human amnion/chorion membrane + standard therapy and standard therapy alone in patients with DFUs were included in the analysis...
September 11, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28894637/epidermal-stem-cells-in-skin-wound-healing
#17
REVIEW
Yuanyuan Li, Jamie Zhang, Jiping Yue, Xuewen Gou, Xiaoyang Wu
Significance: Skin serves as a protective barrier for mammals. Epidermal stem cells are responsible for maintaining skin homeostasis. When cutaneous injuries occur, skin homeostasis and integrity are damaged, leading to dire consequences such as acute, chronic, or infected wounds. Skin wound healing is an intrinsic self-saving chain reaction, which is crucial to facilitating the replacement of damaged or lost tissue. Recent Advances: An immense amount of research has uncovered the underlying mechanisms behind the complex and highly regulated wound healing process...
September 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28894635/topical-naltrexone-is-a-safe-and-effective-alternative-to-standard-treatment-of-diabetic-wounds
#18
Patricia J McLaughlin, Jarrett D Cain, Michelle B Titunick, Joseph W Sassani, Ian S Zagon
Objective: Diabetes affects more than 29 million individuals in the United States, resulting in healthcare costs approaching $245 billion. Approximately 15% of these individuals will develop a chronic, non-healing foot ulcer (diabetic foot ulcer [DFU]) that, if untreated, may lead to amputation. The current treatments for DFU are expensive, have significant side-effects, and often result in non-compliance. A new topical treatment is described that accelerates cutaneous wound repair and is disease modifying by targeting underlying aberrant diabetic pathways...
September 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28893707/endovascular-aorto-iliac-revascularization-in-a-patient-with-spinal-cord-injury-and-hip-contracture
#19
Naixin Kang, Stefan Kenel-Pierre, Hilene DeAmorim, John Karwowski, Arash Bornak
Treatment of chronic peripheral ischemic wounds in patients with spinal cord injury (SCI) can be technically challenging, especially if they have significant hip contracture. This paper describes the endovascular aorto-iliac revascularization of a paraplegic patient with hip contracture and a hostile abdomen. It also reviews the particularity of the peripheral arterial system in SCI patients.
September 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28893557/transcription-factor-cux1-is-required-for-intestinal-epithelial-wound-healing-and-targets-the-vav2-rac1-signalling-complex
#20
Roxanne Latreille, Raphaëlle Servant, Mathieu Darsigny, Sébastien Marcoux, Christine Jones, Nathalie Perreault, François Boudreau
Intestinal epithelial cells form a protective barrier in limiting gut luminal content potentially harmful to the host. Upon gut epithelium injury, several signals instruct epithelial cells to undergo a rapid healing process. Defects in this process induce inflammatory responses and can further evolve into chronic gut inflammatory diseases. We previously identified the transcription factor CUX1 as crucial for protecting against experimental colitis in mice. However, the precise molecular mechanisms by which CUX1 intervenes during this biological process are unknown...
September 8, 2017: Biochimica et Biophysica Acta
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