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Thermal ablation

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https://www.readbyqxmd.com/read/28648469/long-term-clinical-outcomes-following-radiofrequency-and-microwave-ablation-of-renal-cell-carcinoma-at-a-single-va-medical-center
#1
Salim E Abboud, Tanay Patel, Stephanie Soriano, Joseph Giesler, Nannette Alvarado, Preet Kang
PURPOSE: Microwave ablation (MWA) is a relatively newer treatment modality for treatment of renal cell carcinoma (RCC), and only a few small studies have examined the short- and long-term outcomes for MWA applied to renal tumors. The purpose of this retrospective review is to assess the initial experience including technical short- and long-term success rates of using radiofrequency ablation (RFA) and MWA for RCC at a single Veterans Affairs (VA) medical center. MATERIALS AND METHODS: Tumor characteristics were recorded using the R...
May 17, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28647287/microwave-thermal-ablation-effects-of-tissue-properties-variations-on-predictive-models-for-treatment-planning
#2
Vanni Lopresto, Rosanna Pinto, Laura Farina, Marta Cavagnaro
Microwave thermal ablation (MTA) therapy for cancer treatments relies on the absorption of electromagnetic energy at microwave frequencies to induce a very high and localized temperature increase, which causes an irreversible thermal damage in the target zone. Treatment planning in MTA is based on experimental observations of ablation zones in ex vivo tissue, while predicting the treatment outcomes could be greatly improved by reliable numerical models. In this work, a fully dynamical simulation model is exploited to look at effects of temperature-dependent variations in the dielectric and thermal properties of the targeted tissue on the prediction of the temperature increase and the extension of the thermally coagulated zone...
June 21, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28640198/experimental-investigation-of-magnetic-nanoparticle-enhanced-microwave-hyperthermia
#3
Brogan T McWilliams, Hongwang Wang, Valerie J Binns, Sergio Curto, Stefan H Bossmann, Punit Prakash
The objective of this study was to evaluate microwave heating enhancements offered by iron/iron oxide nanoparticles dispersed within tissue-mimicking media for improving efficacy of microwave thermal therapy. The following dopamine-coated magnetic nanoparticles (MNPs) were considered: 10 and 20 nm diameter spherical core/shell Fe/Fe₃O₄, 20 nm edge-length cubic Fe₃O₄, and 45 nm edge-length/10 nm height hexagonal Fe₃O₄. Microwave heating enhancements were experimentally measured with MNPs dissolved in an agar phantom, placed within a rectangular waveguide...
June 22, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28638789/multidisciplinary-approach-of-colorectal-cancer-liver-metastases
#4
REVIEW
Giammaria Fiorentini, Donatella Sarti, Camillo Aliberti, Riccardo Carandina, Andrea Mambrini, Stefano Guadagni
Large bowel cancer is a worldwide public health challenge. More than one third of patients present an advanced stage of disease at diagnosis and the liver is the most common site of metastases. Selection criteria for early diagnosis, chemotherapy and surgery have been recently expanded. The definition of resectability remains unclear. The presence of metastases is the most significant prognostic factor. For this reason the surgical resection of hepatic metastases is the leading treatment. The most appropriate resection approach remains to be defined...
June 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28634923/osteoblastoma-of-the-elbow-analysis-of-13-patients-and-literature-review
#5
Andrea Angelini, Andrès Felipe Varela-Osorio, Giulia Trovarelli, Antonio Berizzi, Gabriele Zanotti, Pietro Ruggieri
PURPOSE: To analyze the clinical and radiographic characteristics, treatment, and outcome of patients with elbow osteoblastoma. PATIENTS AND METHODS: We present 13 patients (7 males and 6 females; mean age, 28 years) diagnosed and treated for an elbow osteoblastoma from 1975 to 2012. Mean follow-up was 29 months (range 12-60 months). Clinical presentation, imaging, surgical treatment, complications, range of elbow motion, and functional outcome were evaluated...
June 20, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28633589/laser-induced-thermal-ablation-of-cancerous-cell-organelles
#6
Renat R Letfullin, Scott A Szatkowski
AIM: By exploiting the physical changes experienced by cancerous organelles, we investigate the feasibility of destroying cancerous cells by single and multipulse modes of laser heating. MATERIALS & METHODS: Our procedure consists of two primary steps: determining the normal and cancerous organelles optical properties and simulating the heating of all of the major organelles in the cell to find the treatment modes for the laser ablation of cancerous organelles without harming healthy cells...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28632988/solid-sampling-with-a-diode-laser-for-portable-ambient-mass-spectrometry
#7
Yeni P Yung, Raveendra Wickramasinghe, Anu Vaikkinen, Tiina Johanna Kauppila, Igor V Veryovkin, Luke Hanley
A handheld diode laser is implemented for solid sampling in portable ambient mass spectrometry (MS). Specifically, a pseudo-continuous wave battery-powered surgical laser diode is employed for portable laser diode thermal desorption (LDTD) at 940 nm and compared with nanosecond pulsed laser ablation at 2940 nm. Postionization is achieved in both cases using atmospheric pressure photoionization (APPI). The laser ablation atmospheric pressure photoionization (LAAPPI) and LDTD-APPI mass spectra of sage leaves (Salvia officinalis) using a field-deployable quadrupole ion trap MS display many similar ion peaks, as do the mass spectra of membrane grown biofilms of Pseudomonas aeruginosa...
June 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28631963/tumor-penetrating-peptide-integrated-thermally-sensitive-liposomal-doxorubicin-enhances-efficacy-of-radiofrequency-ablation-in-liver-tumors
#8
Fei Yan, Song Wang, Wei Yang, S Nahum Goldberg, Hao Wu, Wan-Lu Duan, Zhi-Ting Deng, Hai-Bo Han, Hai-Rong Zheng
Purpose To investigate the role of a tumor-penetrating peptide (internalizing CRGDRGPDC [iRGD])-integrated thermally sensitive liposomal (TSL) doxorubicin (DOX) in combination with radiofrequency (RF) ablation of liver tumors in an animal model. Materials and Methods Approval from the institutional animal care and use committee was obtained. Characterization of iRGD-TSL-DOX was performed in vitro. Next, H22 liver adenocarcinomas were implanted in 138 mice in vivo. The DOX accumulation and cell apoptosis of iRGD-TSL-DOX and TSL-DOX with or without RF were evaluated (n = 5) at different time points after treatment with quantitative analysis or pathologic staining...
June 19, 2017: Radiology
https://www.readbyqxmd.com/read/28623990/incidence-of-venous-leg-ulcer-healing-and-recurrence-after-treatment-with-endovenous-laser-ablation
#9
William A Marston, Jason Crowner, Ana Kouri, Corey A Kalbaugh
BACKGROUND: The Effect of Surgery and Compression on Healing and Recurrence (ESCHAR) trial previously reported that patients with venous leg ulcers treated with saphenous stripping experienced a significantly reduced incidence of ulcer recurrence compared with patients treated with compression therapy. Most patients with leg ulcers and saphenous insufficiency are currently treated with endovenous thermal ablation (EVTA), but little information is available on the long-term results after EVTA in Clinical, Etiology, Anatomy, and Pathophysiology (CEAP) clinical class 5 (C5) and class 6 (C6) patients...
July 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28618498/magnetohydrodynamics-of-laser-produced-high-energy-density-plasma-in-a-strong-external-magnetic-field
#10
Kazuki Matsuo, Hideo Nagatomo, Zhe Zhang, Philippe Nicolai, Takayoshi Sano, Shohei Sakata, Sadaoki Kojima, Seung Ho Lee, King Fai Farley Law, Yasunobu Arikawa, Youichi Sakawa, Taichi Morita, Yasuhiro Kuramitsu, Shinsuke Fujioka, Hiroshi Azechi
Recent progress in the generation in the laboratory of a strong (>100-T) magnetic field enables us to investigate experimentally unexplored magnetohydrodynamics phenomena of a high-energy-density plasma, which an external magnetic field of 200-300 T notably affects due to anisotropic thermal conduction, even when the magnetic field pressure is much lower than the plasma pressure. The external magnetic field reduces electron thermal conduction across the external magnetic field lines because the Larmor radius of the thermal electrons in the external magnetic field is much shorter than the mean free path of the thermal electrons...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28612019/thermal-ablation-in-the-management-of-colorectal-cancer-patients-with-oligometastatic-liver-disease
#11
REVIEW
Elena Nadia Petre, Constantinos Sofocleous
BACKGROUND: Surgical resection of limited colorectal liver disease improves long-term survival and can be curative in a subset of selected cases. Image-guided percutaneous ablation therapies have emerged as safe and effective alternative options for selected patients with unresectable colorectal liver metastases (CLM) that can be ablated with margins. Ablation causes focal destruction of tissue and has increasingly been shown to provide durable eradication of tumors. METHODS: A selective review of literature was conducted in PubMed, focusing on recent studies reporting on the safety, efficacy, and long-term outcomes of percutaneous ablation modalities in the treatment of CLM...
March 2017: Visceral Medicine
https://www.readbyqxmd.com/read/28611425/pancreatic-adenocarcinoma-response-to-chemotherapy-enhanced-with-non-invasive-radio-frequency-evaluated-via-an-integrated-experimental-computational-approach
#12
Matthew J Ware, Louis T Curtis, Min Wu, Jason C Ho, Stuart J Corr, Steven A Curley, Biana Godin, Hermann B Frieboes
Although chemotherapy combined with radiofrequency exposure has shown promise in cancer treatment by coupling drug cytotoxicity with thermal ablation or thermally-induced cytotoxicity, limited access of the drug to tumor loci in hypo-vascularized lesions has hampered clinical application. We recently showed that high-intensity short-wave capacitively coupled radiofrequency (RF) electric-fields may reach inaccessible targets in vivo. This non-invasive RF combined with gemcitabine (Gem) chemotherapy enhanced drug uptake and effect in pancreatic adenocarcinoma (PDAC), notorious for having poor response and limited therapeutic options, but without inducing thermal injury...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28610455/non-fourier-thermal-transport-induced-structural-hierarchy-and-damage-to-collagen-ultrastructure-subjected-to-laser-irradiation
#13
Nilamani Sahoo, Arunn Narasimhan, Purbarun Dhar, Sarit Kumar Das
Comprehending the mechanism of thermal transport through biological tissues is an important factor for optimal ablation of cancerous tissues and minimising collateral tissue damage. The present study reports detailed mapping of the rise in internal temperature within the tissue mimics due to NIR (1064 nm) laser irradiation, both for bare mimics and with gold nanostructures infused. Gold nanostructures such as mesoflowers and nano spheres have been synthesized and used as photothermal converters to enhance the temperature rise, resulting in achieving the desired degradation of malignant tissue in targeted region...
June 13, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28604815/temperature-sensitive-liposomes-combined-with-thermal-ablation-effects-of-duration-and-timing-of-heating-in-mathematical-models-and-in-vivo
#14
Christian Rossmann, M A McCrackin, Kent E Armeson, Dieter Haemmerich
BACKGROUND: Temperature sensitive liposomes (TSL) are nanoparticles that rapidly release the contained drug at hyperthermic temperatures, typically above ~40°C. TSL have been combined with various heating modalities, but there is no consensus on required hyperthermia duration or ideal timing of heating relative to TSL administration. The goal of this study was to determine changes in drug uptake when heating duration and timing are varied when combining TSL with radiofrequency ablation (RF) heating...
2017: PloS One
https://www.readbyqxmd.com/read/28604147/nak-alloy-induced-in-vivo-tumor-ablation-therapy
#15
Wei Wang, Ying Liu, Huan Liu, Yonghui An, Qian Wang, Jing Liu
PURPOSE: Alkali metal ablation is newly emerging as an effective, economic and minimally invasive ablation therapy. This study is dedicated to demonstrate the high efficiency of NaK alloy ablation on in vivo tumors with different stages in mice. MATERIAL AND METHODS: Panc02 tumor cells were injected into 21 female C57B/L mice, which were divided into three groups. Two experimental groups of mice received the same percutaneous NaK alloy injection for a week apart...
June 12, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28598516/intratumor-cisplatin-nephrotoxicity-in-combined-laser-induced-thermal-therapy-for-cancer-treatment
#16
Marcel N Palumbo, Onivaldo Cervantes, Cecilia Eugênio, Flávia T P Hortense, João C Ribeiro, Ana Amélia P Paolini, Antônio C Tedesco, Joel A Sercarz, Marcos B Paiva
INTRODUCTION: Thermal ablation of tumors by Nd:YAG laser has been growing as a multidisciplinary subspecialty defined as laser-induced thermal therapy (LITT), and has been increasingly accepted as a minimally invasive method for palliation of advanced or recurrent cancer. Previous studies have shown that adjuvant chemotherapy can potentiate laser thermal ablation of tumors leading to improved palliation in advanced cancer patients. OBJECTIVE: Evaluate nephrotoxicity by early markers of renal function in treating head and neck cancer using intra-tumor injections of cisplatin combined with laser-induced thermal therapy (CDDP-LITT)...
June 9, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28591480/laser-interstitial-thermal-therapy-a-first-line-treatment-for-seizures-due-to-hypothalamic-hamartoma
#17
Victor X Du, Shashank V Gandhi, Harold L Rekate, Ashesh D Mehta
Successful treatment of hypothalamic hamartoma (HH) can result in the resolution of its sequelae including epilepsy and rage attacks. Risks and morbidity of open surgical management of this lesion have motivated the development of laser interstitial thermal therapy (LITT) as a less invasive treatment approach to the disease. Although overall morbidity and risk would appear to be lower, complications related to LITT therapy have been reported, and the longer-term follow-up that is now possible after initial experience helps address the question of whether LITT provides equivalent efficacy compared to other treatment options...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28586250/pain-after-percutaneous-irreversible-electroporation-of-renal-tumors-is-not-dependent-on-tumor-location
#18
Igor Sorokin, Aaron H Lay, Nikitha K Reddy, Noah E Canvasser, Murthy Chamarthy, Jeffrey A Cadeddu
Introduction Irreversible electroporation (IRE) is a non-thermal minimally invasive technique to treat small renal masses (SRM). Prior work has demonstrated greater narcotic requirements after radiofrequency ablation (RFA) for tumors closer to body-wall musculature. We hypothesized that pain after IRE is not dependent on tumor location due to the athermal mechanistic action. Methods Retrospective review of 50 consecutive percutaneous IRE and RFA cases was performed from 2013 to 2014. Eight patients were excluded from analysis due to incomplete anesthesia record and/or multiple ablations per session leaving 21 patients in each group...
June 6, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28580979/design-of-tpgs-functionalized-cu3bis3-nanocrystals-with-strong-absorption-in-the-second-near-infrared-window-for-radiation-therapy-enhancement
#19
Jiangfeng Du, Xiaopeng Zheng, Yuan Yong, Jie Yu, Xinghua Dong, Chenyang Zhang, Ruyi Zhou, Bai Li, Liang Yan, Chunying Chen, Zhanjun Gu, Yuliang Zhao
Integrating radiation therapy with high-depth photothermal therapy in the second near-infrared (NIR) window is highly required for efficient treatment of deep-seated tumor cells. Here, we constructed a multifunctional nano-theranostic with bimetallic chalcogenide nanocrystals (NCs) functionalized with amphiphilic d-α-tocopherol polyethylene glycol 1000 succinate (TPGS-Cu3BiS3). Benefiting from the strong absorbance of both X-ray and NIR light in the second NIR window, TPGS-Cu3BiS3 CNs can not only deposit more radiation dose to trigger enhanced radiation damage in vivo, but also conduct photo-induced hyperthermia for thermal ablation in the second NIR window and effective improvement of tumor oxygenation to overcome the hypoxia-associated radio-resistance of tumors...
June 5, 2017: Nanoscale
https://www.readbyqxmd.com/read/28580377/optimization-of-curvilinear-needle-trajectories-for-transforamenal-hippocampotomy
#20
David B Comber, E Bryn Pitt, Hunter B Gilbert, Matthew W Powelson, Emily Matijevich, Joseph S Neimat, Robert J Webster, Eric J Barth
BACKGROUND: The recent development of MRI-guided laser-induced thermal therapy (LITT) offers a minimally invasive alternative to craniotomies performed for tumor resection or for amygdalohippocampectomy to control seizure disorders. Current LITT therapies rely on linear stereotactic trajectories that mandate twist-drill entry into the skull and potentially long approaches traversing healthy brain. The use of robotically-driven, telescoping, curved needles has the potential to reduce procedure invasiveness by tailoring trajectories to the curved shape of the ablated structure and by enabling access through natural orifices...
February 2017: Operative Neurosurgery (Hagerstown, Md.)
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