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Enqiang Linghu, Ningli Chai, Chen Du, Bo Ning, Zhiqiang Wang, Yufa Sun, Wei Xu, Huikai Li, Lihua Sun, Wei Zhang, Xu Guo, Xiangdong Wang, Ping Tang, Jia Feng
BACKGROUND AND AIMS: With the development of imaging techniques, the detection rate of pancreatic cystic neoplasms (PCNs) has increased. The surgical morbidity and mortality rates of PCNs are quite high. This study is intended to evaluate the safety and effectiveness of a minimally invasive treatment, EUS-guided PCNs ablation with lauromacrogol. METHODS: From April 2015 to May 2016, 120 patients with PCNs were enrolled to undergo EUS. We prospectively studied 29 of the 120 patients that underwent EUS-guided ablation with lauromacrogol...
March 29, 2017: Gastrointestinal Endoscopy
Li Liu, Dong-Xiao Liu, Ji-Hong Zhao, Yu Cai, Hao-Yan Zhong
PURPOSE: To compare the clinical efficacy of pingyangmycin and lauromacrogol combined with pingyangmycin in the treatment of venous malformations (VMs). METHODS: One hundred and twenty patients with VM were randomly divided into lauromacrogol combined with pingyangmycin injection group (experimental group) and pingyangmycin injection group (control group). The appropriate interval between different injection sessions was 2 weeks. After different sessions, the changes of lesions (including size, color, texture) as well as the results of posture test and adverse effects were analyzed by using SPSS11...
October 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
Zhi-Jiang Chen, Long Wang, Yi-Jing Huang, Shui-Qing Lai, Hong-Mei Chen, Jian-Hao Pei, Shu-Zhen Cong, Jian Kuang
OBJECTIVE: To evaluate the clinical efficacy of ultrasound-guided lauromacrogol sclerotherapy for benign thyroid cysts and analyze the factors affecting the efficacy. METHODS: Ultrasound-guided lauromacrogol sclerotherapy was performed in 97 patients with a total of 99 benign thyroid cysts. The changes in cystic volume and other thyroid parameters were evaluated at 1, 3, 6, and 12 months after sclerotherapy. According to changes in the cystic volume, the efficacy of sclerotherapy was defined as therapeutic failure (with a volume reduction <50%), treatment success (volume reduction ≥50%) and cure (volume reduction ≥90%)...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
F Bian, G L Zhang, F M Wang, D Yang, Y Y Gao, J Li, Y Li
No abstract text is available yet for this article.
October 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Xiao-Qing Zeng, Li-Li Ma, Yu-Jen Tseng, Jie Chen, Chun-Xiao Cui, Tian-Cheng Luo, Jian Wang, Shi-Yao Chen
BACKGROUND AND AIM: Current guidelines recommend injection of cyanoacrylate as first-line therapy to prevent gastric variceal rebleeding. The method still poses a risk of ectopic embolism, which possibly correlates with the volume of cyanoacrylate used. In this trial, we evaluated the short-term efficacy and safety of tissue adhesive injection combined with lauromacrogol for treating gastric varices. METHODS: Patients admitted to our hospital for variceal hemorrhage were enrolled and blindly randomized into two treatment groups: lauromacrogol group (lauromacrogol-cyanoacrylate-lauromacrogol) and lipiodol group (lipiodol-cyanoacrylate-lipiodol)...
March 2017: Journal of Gastroenterology and Hepatology
Xingxing Huang, Haixiao Zou, Xiaoke Guo, Yifang Zhao
OBJECTIVE: To explore the curative effect of surgery and selerotherapy for massive venous malformations of the tongue. METHODS: From January 2005 to December 2014, subtotal resection or debulking for 15 cases of massive venous malformation in the tongue was undertaken with multiple sessions of pre- and post-operative injection therapy of pingyangmycin, lauromacrogol and absolute ethanol. RESULTS: All signs associated with the lesions including eating, sleep and speech disorders disappeared after treatment...
January 2016: Zhonghua Zheng Xing Wai Ke za Zhi, Zhonghua Zhengxing Waike Zazhi, Chinese Journal of Plastic Surgery
Ufuk Oguz Idiz, Erhan Aysan, Ismail Can, Nur Buyukpinarbasili, Erkan Yardimci Yardimci, Huseyin Bektasoglu
AIM: The effects of lauromacrogol as a sclerosing agent were evaluated on rabbit thyroid tissue. MATERIAL AND METHODS: Twelve rabbits were divided into two equal groups. Intra-thyroid injections of 0.1 ml lauromacrogol were administered in the study group and 0.1 ml physiologic serum in the control group. The blood levels of free T3, free T4, TSH, postoperative adhesions and histopathologic differences of the thyroid tissues were evaluated. RESULTS: The values of serum free T3, free T4 and TSH levels did not differ significantly (p>0...
2016: Annali Italiani di Chirurgia
S Doganci, V Yildirim, G Erol, F Yesildal, K Karabacak, M Kadan, G Ozkan, M E Ince, T Ozgurtas
OBJECTIVE: Polidocanol is the most frequently used sclerosant for sclerotherapy all around the world. Our experimental research aims to find out the angiogenic effects of Polidocanol. MATERIALS AND METHODS: Angiogenic activity of polidocanol was examined in vivo in the chick chorioallantoic membrane (CAM) model, cell viability assay (human umbilical vein endothelial cells - HUVECs) and in vitro tube formation assay of HUVECs. RESULTS: In CAM assay, a significant decrease on CAM vessel growth was observed after the application of polidocanol solutions...
April 2016: European Review for Medical and Pharmacological Sciences
Wei Liu, LongXia Wang, Cui-Xia Guo
OBJECTIVE: To determine the effectiveness of different concentrations of lauromacrogol injections for the treatment of endometriosis in an experimental animal model and to provide an experimental basis for a pre-clinical application of the drug. METHODS: After autologous transplantation of endometrial tissue, 40 endometrial cysts were successfully established and randomly divided into three groups: a 1 % lauromacrogol injection group, a 0.5 % lauromacrogol injection group, and cysts without intervention (control group)...
September 2016: Archives of Gynecology and Obstetrics
Paolo Farneti, Ernesto Pasquini, Vittorio Sciarretta, Giovanni Macrì, Giulia Gramellini, Antonio Pirodda
OBJECTIVES: Epistaxis is one of the most common otorhinolaryngologic emergencies representing more than 12% of conditions managed at the Ear, Nose and Throat (ENT) Emergency Consulting Room of our Otorhinolaryngologic Unit each year. The elevated frequency of this pathology makes it necessary to adopt the most effective and least expensive therapeutic strategy available. The aim of this study was to compare the efficacy, costs and morbidity of nasal packing (NP), which is the mainstay of treatment for anterior epistaxis in our ENT Emergency Consulting Room versus submucosal infiltrations of lauromacrogol (LA)...
June 2016: Clinical and Experimental Otorhinolaryngology
Xu Miao, OuYang Tianxiang, Xiao Yan, Huang Yingying, Chen Huiping, Yu Jie, Ma Xiaorong, Zhao Tinghui, Chang Mengling, Lin Jun, Liu Jun
OBJECTIVE: To summarize the management of infant vascular tumors with Kasabach-Merritt phenomenon (KMP) and to evaluate the effect of drug combined with sclerotherapy. METHODS: From Feb. 2007 to Nov. 2014, 25 cases with KMP, who underwent drug therapy combined with sclerotherapy, were retrospectively studied. Oral corticosteroids (2 mg/kg per day) was used as the first-line therapy on all of the patients and intravenous vincristine (1.5 mg/m2 every week) was added when the platelet counts didn't recover obviously after 2-3 weeks...
July 2015: Zhonghua Zheng Xing Wai Ke za Zhi, Zhonghua Zhengxing Waike Zazhi, Chinese Journal of Plastic Surgery
Jie Tan, Siqing Yang, Xia Tian, Zheng Han, Qingxi Zhu
No abstract text is available yet for this article.
August 2015: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Jie Chen, Xiao-Qing Zeng, Li-Li Ma, Bing Li, Yu-Jen Tseng, Jing-Jing Lian, Hong Gao, Jian Wang, Tian-Cheng Luo, Shi-Yao Chen
OBJECTIVES: A recently published network meta-analysis showed that ligation combined with sclerotherapy might be the most efficacious intervention for secondary prophylaxis of variceal bleeding. Most studies excluded patients with concomitant gastric varices; thus, the outcomes in such patients have not yet been reported. The present study aimed to investigate the efficacy of two endoscopic procedures for secondary prophylaxis in cirrhotic patients presenting with both esophageal and gastric varices...
January 2016: European Journal of Gastroenterology & Hepatology
Loes M C F Bielefeld, Marjan J W Aldenzee
A 23-year-old woman developed painful skin necrosis after injections with lauromacrogol 400 for varicose veins. This complication, called embolia cutis medicamentosa or Nicolau syndrome, is characterised by acute pain and necrosis of the skin, subcutaneous tissue and muscle. Surgical intervention by local excision seems to be the best therapy.
2015: Nederlands Tijdschrift Voor Geneeskunde
Sida Xu, Qiang Wei, Youfen Fan, Shihai Chen, Qingfeng Liu, Guoqiang Yin, Mingde Liao, Yu Sun
OBJECTIVE: To explore the effect of microneedle combined with Lauromacrogol on skin capillary network. METHODS: 24 male Leghone (1.5-2.0 kg in weight) were randomly divided into three groups as group A (microneedle combined with Lauromacrogol), B (microneedle combined with physiological saline) , and C(control). The cockscombs were treated. The specimens were taken on the 7th, 14th, 21th , and 28th day postoperatively. HE staining, immunohistochemical staining and special staining were performed for study of the number of capillary and collagen I/III , as well as elastic fibers...
November 2014: Zhonghua Zheng Xing Wai Ke za Zhi, Zhonghua Zhengxing Waike Zazhi, Chinese Journal of Plastic Surgery
Jie Xue, Xianhui Geng
This research aims to analyze the curative effect and security of lauromacrogol injection and absolute ethyl alcohol treating simplex hepatic cyst respectively. The simplex hepatic cyst patients were divided into lauromacrogol group (86 cases, research group) and absolute ethyl alcohol group (80 cases, control group). Both two groups received sclerotherapy of thoracic drainage under ultrasonic guidance and the curative effect and untoward effect were observed. The result showed there was no hemorrhage or infection within two groups...
March 2015: Pakistan Journal of Pharmaceutical Sciences
Yehiel Ziv, Avinoam Nevler, Ehud Willenz, Ofer Doron, Andrew Zbar, Aino Shperber, Judith Sandbank
BACKGROUND: New animal models provide insights into the pathogenesis of different types of inflammatory bowel disease as well as novel pathways for new therapeutic options. However, the scarcity of large animal models hinders the research and development of new surgical procedures and technological devices in inflammatory bowel disease surgery. Common small animal inducible models involve chemical agents that result in the development of acute intestinal inflammation. OBJECTIVES: To assess a novel method for the induction of Crohn's-like colitis using intramural injection of sclerosants in a porcine model...
January 2015: Israel Medical Association Journal: IMAJ
Zhenkai Wang, Xiaoqian Yang, Lin Wu, Hui Shi, Youke Lu, Boshi Yuan, Yanxia Wang, Fangyu Wang
No abstract text is available yet for this article.
May 2015: Gastrointestinal Endoscopy
Xia Zhou, Yanggui Xie, Qi Cui, Xiaoping Xu, Maosheng He, Bo Liang
OBJECTIVE: To evaluate the safety and efficacies of ultrasound-guided sclerotherapy of uterine fibroids with lauromacrogol. METHODS: A total of 102 consecutive premenopausal women with 113 uterine fibroids were enrolled. The treatment of lauromacrogol was performed under the guidance of ultrasound. Both conventional and color Doppler ultrasound were performed before treatment and at Month 1, 3, 6 and 12 after treatment. The changes of tumor volume reductions and vascular flow were analyzed and compared...
July 22, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Yuuka Shibata, Yuta Tanaka, Takashi Tomita, Takanori Taogoshi, Yasuhiro Kimura, Taiichiro Chikama, Kenji Kihira
PURPOSE: To compare the cytotoxicity of povidone-iodine solution (PVP-I) with that of polyvinyl alcohol-iodine solution (PAI) for ophthalmic use. METHODS: Cells of the human corneal epithelial cell line HCE-T were exposed to various dilutions of PVP-I or PAI, and the cytotoxicity of these two antiseptics was evaluated. The relative toxicities of PVP-I and PAI were also investigated following the inactivation of iodine by achromatization with sodium thiosulfate. RESULTS: PVP-I and PAI had equivalent antiseptic effects, but the cytotoxicity of PVP-I diluted 16-fold was higher than that of PAI diluted 6-fold...
November 2014: Japanese Journal of Ophthalmology
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