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https://www.readbyqxmd.com/read/29468163/the-effect-of-flaxseed-in-breast-cancer-a-literature-review
#1
REVIEW
Ana Calado, Pedro Miguel Neves, Teresa Santos, Paula Ravasco
Breast cancer is one of the most common cancers and the second most responsible for cancer mortality worldwide. In 2014, in Portugal approximately 27,200 people died of cancer, of which 1,791 were women with breast cancer. Flaxseed has been one of the most studied foods, regarding possible relations to breast cancer, though mainly in experimental studies in animals, yet in few clinical trials. It is rich in omega-3 fatty acids, α-linolenic acid, lignan, and fibers. One of the main components of flaxseed is the lignans, of which 95% are made of the predominant secoisolariciresinol diglucoside (SDG)...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29461968/the-role-of-exercise-and-hyperlipidaemia-in-breast-cancer-progression
#2
Linda A Buss, Gabi U Dachs
Exercise reduces the risk of breast cancer development and improves survival in breast cancer patients. However, the underlying mechanisms of this protective effect remain to be fully elucidated. It is unclear whether exercise can attenuate or modify the pro-tumour effects of obesity and related conditions, such as hyperlipidaemia. This review summarises how hyperlipidaemia and exercise contribute to or reduce breast cancer risk and progression, respectively, and highlights the possible mechanisms behind each...
2018: Exercise Immunology Review
https://www.readbyqxmd.com/read/29458781/melatonin-and-breast-cancer-evidences-from-preclinical-and-human-studies
#3
REVIEW
Peter Kubatka, Pavol Zubor, Dietrich Busselberg, Taeg Kyu Kwon, Mariusz Adamek, Daniel Petrovic, Radka Opatrilova, Katarina Gazdikova, Martin Caprnda, Luis Rodrigo, Jan Danko, Peter Kruzliak
The breast cancer affects women with high mortality and morbidity worldwide. The risk is highest in the most developed world but also is markedly rising in the developing countries. It is well documented that melatonin has a significant anti-tumor activities demonstrated on various cancer types in a plethora of preclinical studies. In breast cancer, melatonin is capable to disrupt estrogen-dependent cell signaling, resulting in a reduction of estrogen-stimulated cells, moreover, it's obvious neuro-immunomodulatory effect in organism was described...
February 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29456806/women-with-hereditary-breast-cancer-predispositions-should-avoid-using-their-smartphones-tablets-and-laptops-at-night
#4
EDITORIAL
Seyed Ali Reza Mortazavi, Seyed Mohammad Javad Mortazavi
Breast cancer is the most common malignancy among women, both in the developed and developing countries. Women with mutations in the BRCA1 and BRCA2 genes have an increased risk of breast and ovarian cancers. Recent studies show that short-wavelength visible light disturb the secretion of melatonin and causes circadian rhythm disruption. We have previously studied the health effects of exposure to different levels of radiofrequency electromagnetic fields (RF-EMFs) such as mobile phones, mobile base stations, mobile phone jammers, laptop computers, and radars...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456469/prophylactic-surgery-for-whom-when-and-how
#5
REVIEW
Christine Mau, Michael Untch
Risk-reducing surgery has proved to be a reasonable procedure in healthy women with a definitely elevated risk of developing cancer. Here we consider the elevated risk of breast and ovarian cancer. There is a clear indication for such surgery in healthy women with a pathogenic BRCA1/2 mutation. For these patients, a risk-reducing bilateral mastectomy leads to a verifiable reduction in mortality from breast cancer, particularly for young patients. In most cases, surgery is combined with breast reconstruction...
December 2017: Breast Care
https://www.readbyqxmd.com/read/29450675/lipid-lowering-drugs-dyslipidemia-and-breast-cancer-risk-in-a-medicare-population
#6
Catherine Schairer, D Michal Freedman, Shahinaz M Gadalla, Ruth M Pfeiffer
PURPOSE: We sought to disentangle the effects of statins and other lipid-lowering drugs and the underlying dyslipidemia for which they are prescribed on breast cancer risk. METHODS: We conducted a case-control study within the linked Surveillance, Epidemiology, and End results (SEER)-Medicare data. Cases were women with invasive breast cancer aged 66 + years (N = 30,004) identified by SEER registries (years 2007-2011). Controls were women (N = 198,969) identified from a 5% random sample of Medicare recipients alive and breast cancer free in year of selection...
February 15, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29445900/clinical-interpretation-of-pathogenic-atm-and-chek2-variants-on-multigene-panel-tests-navigating-moderate-risk
#7
Allison H West, Kathleen R Blazer, Jessica Stoll, Matthew Jones, Caroline M Weipert, Sarah M Nielsen, Sonia S Kupfer, Jeffrey N Weitzel, Olufunmilayo I Olopade
Comprehensive genomic cancer risk assessment (GCRA) helps patients, family members, and providers make informed choices about cancer screening, surgical and chemotherapeutic risk reduction, and genetically targeted cancer therapies. The increasing availability of multigene panel tests for clinical applications allows testing of well-defined high-risk genes, as well as moderate-risk genes, for which the penetrance and spectrum of cancer risk are less well characterized. Moderate-risk genes are defined as genes that, when altered by a pathogenic variant, confer a 2 to fivefold relative risk of cancer...
February 14, 2018: Familial Cancer
https://www.readbyqxmd.com/read/29434658/healthy-living-and-cancer-evidence-from-uk-biobank
#8
Peter C Elwood, Alex Whitmarsh, John Gallacher, Anthony Bayer, Richard Adams, Luke Heslop, Janet Pickering, Gareth Morgan, Julieta Galante, Sunil Dolwani, Marcus Longley, Zoe E Roberts
Context: UK Biobank is a prospective study of half a million subjects, almost all aged 40-69 years, identified in 22 centres across the UK during 2006-2010. Objective: A healthy lifestyle has been described as 'better than any pill, and no side effects [5]. We therefore examined the relationships between healthy behaviours: low alcohol intake, non-smoking, healthy BMI, physical activity and a healthy diet, and the risk of all cancers, colon, breast and prostate cancers in a large dataset...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29424028/a-test-for-gene-environment-interaction-in-the-presence-of-measurement-error-in-the-environmental-variable
#9
Hugues Aschard, Donna Spiegelman, Vincent Laville, Pete Kraft, Molin Wang
The identification of gene-environment interactions in relation to risk of human diseases has been challenging. One difficulty has been that measurement error in the exposure can lead to massive reductions in the power of the test, as well as in bias toward the null in the interaction effect estimates. Leveraging previous work on linear discriminant analysis, we develop a new test of interaction between genetic variants and a continuous exposure that mitigates these detrimental impacts of exposure measurement error in ExG testing by reversing the role of exposure and the diseases status in the fitted model, thus transforming the analysis to standard linear regression...
February 8, 2018: Genetic Epidemiology
https://www.readbyqxmd.com/read/29416994/a-study-on-awareness-about-breast-carcinoma-and-practice-of-breast-self-examination-among-basic-sciences-college-students-bengaluru
#10
Suwarna Madhukumar, Uthraa R Thambiran, Bhavya Basavaraju, Mayur R Bedadala
Background: In India, the number of new breast cancer cases is about 115,000 per year and this is expected to rise to 250,000 new cases per year by 2015. It needs to be noted that breast cancer is leading in the age groups of 15-34 years which is a cause of concern as this denotes the need for educative and awareness programs targeting younger members of the society, to implement early practices of breast examination. This study was carried out with the intention of assessing the level of knowledge and awareness of carcinoma breast and breast self-examination (BSE) in female college students...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29414985/the-quaternary-state-of-polymerized-human-hemoglobin-regulates-oxygenation-of-breast-cancer-solid-tumors-a-theoretical-and-experimental-study
#11
Donald A Belcher, Julia A Ju, Jin Hyen Baek, Ayla Yalamanoglu, Paul W Buehler, Daniele M Gilkes, Andre F Palmer
A major constraint in the treatment of cancer is inadequate oxygenation of the tumor mass, which can reduce chemotherapeutic efficacy. We hypothesize that polymerized human hemoglobin (PolyhHb) can be transfused into the systemic circulation to increase solid tumor oxygenation, and improve chemotherapeutic outcomes. By locking PolyhHb in the relaxed (R) quaternary state, oxygen (O2) offloading at low O2 tensions (<20 mm Hg) may be increased, while O2 offloading at high O2 tensions (>20 mm Hg) is facilitated with tense (T) state PolyhHb...
2018: PloS One
https://www.readbyqxmd.com/read/29410239/what-the-oncologist-can-learn-from-diabetes-studies-epidemiology-prevention-management-cure
#12
REVIEW
Adriana Albini, Marco Gallo
Notwithstanding massive efforts and investment in improving cancer therapy, the limited progress made in reducing overall mortality has mostly been achieved through early diagnosis. Mortality rates for cardiovascular disease are in decline, a success attributable in large part to an active prevention approach coupled with identification of risk factors and biomarkers. Promising natural and synthetic molecules including numerous flavonoids have the potential to be used in diabetes care and in prevention of cardiovascular pathologies...
February 1, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29405062/cerasomal-lovastatin-nanohybrids-for-efficient-inhibition-of-triple-negative-breast-cancer-stem-cells-to-improve-therapeutic-efficacy
#13
Liujiang Song, Xiaojun Tao, Li Lin, Chao Chen, Hui Yao, Guangchun He, Guangyang Zou, Zhong Cao, Shichao Yan, Lu Lu, Huimei Yi, Di Wu, Siyuan Tan, Wanxin Ouyang, Zhifei Dai, Xiyun Deng
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with a higher risk in younger women and a poorer prognosis and without targeted therapies available currently. Cancer stem cells (CSCs) are increasingly recognized as the main cause of treatment failure and tumor recurrence. The present paper reported the encapsulation of lovastatin (LV) into cerasomes incorporating distearoyl phosphatidylcholine (DSPC) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N -polyethylene glycol 2000 (DSPE-PEG2000) through thin film hydration method in combination with sol-gel reaction and self-assembly process...
February 6, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29401621/il-10-suppresses-tnf-%C3%AE-induced-expression-of-human-aromatase-gene-in-mammary-adipose-tissue
#14
Gabriela Martínez-Chacón, Kristy A Brown, Maria M Docanto, Himanshu Kumar, Seppo Salminen, Niina Saarinen, Sari Mäkelä
White adipose tissue inflammation is linked with increased aromatase gene expression and estrogen production, a major risk factor for breast cancer in obese postmenopausal women. TNF-α, a proinflammatory cytokine, is a key driver of aromatase promoter I.4-mediated expression in adipose tissue. In this study, we have shown that IL-10, an anti-inflammatory cytokine, suppressed both TNF-α-stimulated human aromatase reporter-luciferase (hARO-Luc) expression in mouse bone marrow mesenchymal stromal cells and aromatase gene expression in human breast adipose stromal cells (ASCs)...
January 23, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29399271/extended-adjuvant-aromatase-inhibitor-therapy-in-post-menopausal-women
#15
Stephen M Schleicher, Maura N Dickler
Purpose of the review: To understand the evidence for extending adjuvant aromatase inhibitor (AI) therapy from 5 to 10 years in post-menopausal women with hormone receptor positive (HR+) breast cancer. Recent findings: Multiple large trials have investigated this question. The two trials most representative of the dilemma faced in clinical practice are the MA.17R and NSABP-B42 trials, which both investigated the benefit of continuing versus stopping AI therapy beyond 5 years...
December 2017: Current Breast Cancer Reports
https://www.readbyqxmd.com/read/29388687/interventions-for-weight-reduction-in-obesity-to-improve-survival-in-women-with-endometrial-cancer
#16
REVIEW
Sarah Kitson, Neil Ryan, Michelle L MacKintosh, Richard Edmondson, James Mn Duffy, Emma J Crosbie
BACKGROUND: Diagnoses of endometrial cancer are increasing secondary to the rising prevalence of obesity. Obesity plays an important role in promoting the development of endometrial cancer, by inducing a state of unopposed oestrogen excess, insulin resistance and inflammation. It also affects treatment, increasing the risk of surgical complications and the complexity of radiotherapy planning, and may additionally impact on subsequent survival. Weight-loss interventions have been associated with improvements in breast and colorectal cancer-specific survival as well as a reduction in the risk of cardiovascular disease, a frequent cause of death in endometrial cancer survivors...
February 1, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29380462/cancer-prevention-the-feasibility-and-acceptability-of-promoting-breast-cancer-risk-reduction-in-the-screening-setting-through-a-lifestyle-magazine
#17
Maureen Macleod, Annie S Anderson
Cancer prevention and early detection strategies are fundamental to reducing breast cancer burden. Offering prevention guidance on modifiable risk factors within early detection settings is rare. We aimed to evaluate the acceptability of a magazine focused on lifestyle and cancer prevention for use in breast screening clinics. A lifestyle magazine was developed and distributed within two breast screening settings in the West of Scotland over a 2-month period. Women were either offered the magazine on arrival or in a self-service format...
January 30, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29379834/breast-cancer-screening-in-the-high-risk-population
#18
REVIEW
Mary M Vecchio
The risk for developing breast cancer can be influenced by a number of critical factors. An individual's age, gender, personal and family health history, nutritional status, level of physical activity, environmental exposures, and substance use can significantly shift the recommended screening guidelines format from the general risk population to a high-risk population. It is essential for health-care providers to become proficient in obtaining a complete cancer genetic risk assessment to accurately identify those who may be at high risk...
January 2018: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29374485/fake-facts-and-alternative-truths-in-medical-research
#19
Bjørn Hofmann
BACKGROUND: Fake news and alternative facts have become commonplace in these so-called "post-factual times." What about medical research - are scientific facts fake as well? Many recent disclosures have fueled the claim that scientific facts are suspect and that science is in crisis. Scientists appear to engage in facting interests instead of revealing interesting facts. This can be observed in terms of what has been called polarised research, where some researchers continuously publish positive results while others publish negative results on the same issue - even when based on the same data...
January 27, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29361820/projection-of-breast-cancer-burden-due-to-reproductive-lifestyle-changes-in-korean-women-2013-2030-using-an-age-period-cohort-model
#20
Joo Eun Lee, Sang Ah Lee, Tae Hyun Kim, Sohee Park, Yoon Soo Choy, Yeong Jun Ju, Eun-Cheol Park
Purpose: The aim of this study was to estimate the burden of breast cancer that can be attributed to rapid lifestyle changes in South Korea in 2013-2030. Materials and Methods: An age-period-cohort model was used to estimate the incidence and mortality. The Global Burden of Disease Study Group method was used to calculate the years of life lost and years lived with disability in breast cancer patients using a nationwide cancer registry. The population attributable risks were calculated using meta-analyzed relative risk ratios and by assessing the prevalence of risk factors...
January 22, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
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