keyword
MENU ▼
Read by QxMD icon Read
search

Risk reduction breast cancer

keyword
https://www.readbyqxmd.com/read/29209834/breast-cancer-survivors-return-to-work-and-wage-loss-in-selected-hospitals-in-malaysia
#1
T T Su, M Azzani, F L Tan, S Y Loh
PURPOSE: This study aimed, firstly, to assess the determinants of return to work (RTW), secondly, to explore the amount of annual wage loss, and finally, to discover the determinants of wage loss among breast cancer (BC) survivors. METHODS: A cross-sectional study design was used in this research. The data was collected via interview using a validated questionnaire. Logistic regression models were developed to discover the significant determinants of RTW and of wage loss among BC survivors...
December 5, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29207445/risk-reduction-of-breast-cancer-by-childbirth-breastfeeding-and-their-interaction-in-korean-women-heterogeneous-effects-across-menopausal-status-hormone-receptor-status-and-pathological-subtypes
#2
Seok Hun Jeong, Yoon Suk An, Ji-Yeob Choi, Boyoung Park, Daehee Kang, Min Hyuk Lee, Wonshik Han, Dong Young Noh, Keun-Young Yoo, Sue K Park
Objectives: The purpose of this study was to examine the associations of childbirth, breastfeeding, and their interaction with breast cancer (BC) risk reduction, and to evaluate the heterogeneity in the BC risk reduction effects of these factors by menopause, hormone receptor (HR) status, and pathological subtype. Methods: BC patients aged 40+ from the Korean Breast Cancer Registry in 2004-2012 and controls from the Health Examinee cohort participants were included in this study after 1:1 matching (12 889 pairs) by age and enrollment year...
November 2017: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
https://www.readbyqxmd.com/read/29205077/forty-years-of-landmark-trials-undertaken-by-the-danish-breast-cancer-cooperative-group-dbcg-nationwide-or-in-international-collaboration
#3
Bent Ejlertsen, Birgitte Vrou Offersen, Jens Overgaard, Peer Christiansen, Maj-Britt Jensen, Niels Kroman, Ann Søgaard Knoop, Henning Mouridsen
BACKGROUND: Over the past 40 years the Danish Breast Cancer Cooperative Group (DBCG) has made significant contributions to improve outcome and to make treatment of patients with early breast cancer more tolerable through nationwide and international trials evaluating loco-regional and systemic treatments. These trials have been instrumental to establish standards for the treatment of early breast cancer. METHODS: The DBCG 82 trials had a global impact by documenting that the significant gain in loco-regional recurrence from postmastectomy radiation added to systemic therapy was associated with a reduction in distant recurrence and mortality in high-risk pre- and postmenopausal patients...
December 5, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29204519/cardiac-sparing-radiation-therapy-using-positioning-breast-shell-for-patients-with-left-sided-breast-cancer-who-are-ineligible-for-breath-hold-techniques
#4
Kurian Joseph, Heather Warkentin, Sunita Ghosh, Lee-Anne Polkosnik, Kent Powell, Matthew Brennan, Brad Warkentin, Johanna Jacobs, Khalifa Alkaabi, Susan Chafe, Keith Tankel, Zsolt Gabos, Hong-Wei Liu, Patricia Tai
Purpose: Patients with left-sided breast cancer (LSBC) are at increased risk of cardiac morbidity from adjuvant breast radiation therapy (ABRT). Breath-hold (BH) techniques substantially reduce the radiation received by heart during radiation therapy for LSBC. However, a subset of patients with LSBC are ineligible for BH techniques due to an inability to breath-hold or because of other comorbidities. To reduce radiation to the heart, we routinely use a custom-made breast shell for the treatment of patients with LSBC who are ineligible for BH techniques...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29191123/patient-perceptions-of-barriers-to-self-management-of-breast-cancer-related-lymphedema
#5
Pamela L Ostby, Jane M Armer, Kandis Smith, Bob R Stewart
Breast cancer survivors are at lifetime risk for the development of breast cancer-related lymphedema, a chronic, potentially debilitating condition that requires life-long symptom management. Suboptimal self-management rates suggest that health care providers may not be offering educative-support options that are customized to patient-perceived needs. An Institutional Review Board-approved focus group ( N = 9) and mailed surveys ( N = 15) were used to identify (a) barriers to lymphedema self-management, (b) how breast cancer survivors with lymphedema defined education and support, (c) what type of education and support they had received, and (d) what kind of education and support they wanted...
November 1, 2017: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/29188405/promoting-effects-of-adipose-derived-stem-cells-on-breast-cancer-cells-are-reversed-by-radiation-therapy
#6
Annemarie Baaße, Dajana Juerß, Elaine Reape, Katrin Manda, Guido Hildebrandt
Partial breast irradiation of early breast cancer patients after lumpectomy and the use of endogenous adipose tissue (AT) for breast reconstruction are promising applications to reduce the side effects of breast cancer therapy. This study tries to investigate the possible risks associated with these therapeutic approaches. It also examines the influence of adipose derived stem cells (ADSCs) as part of the breast cancer microenvironment, and endogenous AT on breast cancer cells following radiation therapy. ADSCs, isolated from human reduction mammoplasties of healthy female donors, exhibited multilineage capacity and specific surface markers...
November 29, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29187466/a-comparison-of-the-performance-of-endopredict-clinical-and-nhs-predict-in-120-patients-treated-for-er-positive-breast-cancer
#7
Kinan Mokbel, Umar Wazir, Hiba El Hage Chehade, Aisling Manson, Christina Choy, Victoria Moye, Kefah Mokbel
BACKGROUND: Computational algorithms, such as NHS PREDICT, have been developed using cancer registry data to guide decisions regarding adjuvant chemotherapy. They are limited by biases of the underlying data. Recent breakthroughs in molecular biology have aided the development of genomic assays which provide superior clinical information. In this study, we compared the performance in risk stratification of EndoPredict Clinical (EPClin, a composite of clinical data and EndoPredict) and PREDICT in a cohort of patients with breast cancer considered potential candidates for chemotherapy by the clinicians...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29187227/obesity-reversibly-depletes-the-basal-cell-population-and-enhances-mammary-epithelial-cell-estrogen-receptor-alpha-expression-and-progenitor-activity
#8
Tamara Chamberlin, Joseph V D'Amato, Lisa M Arendt
BACKGROUND: Obesity is correlated with an increased risk for developing postmenopausal breast cancer. Since obesity rates continue to rise worldwide, it is important to understand how the obese microenvironment influences normal mammary tissue to increase breast cancer risk. We hypothesized that obesity increases the proportion of luminal progenitor cells, which are thought to be the cells of origin for the most common types of breast cancer, potentially leading to an increased risk for breast cancer...
November 29, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29185095/management-of-hereditary-breast-and-ovarian-cancer
#9
REVIEW
Hideko Yamauchi, Junko Takei
Hereditary breast and ovarian cancer (HBOC) syndrome represents 5-10% of all breast cancers. In Japan, the HBOC syndrome is frequently diagnosed in patients with breast cancer. Therefore, a treatment strategy combining a plan for existing breast cancer and for reduction of future breast and ovarian cancer risk is necessary. Breast cancer risk-reducing management involves three options-surveillance, chemoprevention, and risk-reducing mastectomy (RRM). RRM can prevent >90% of new breast cancers. Ovarian cancer risk management options are more limited, and risk-reduction salpingo-oophorectomy is the only option since there is no proven effective early detection method available...
November 28, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29182397/breast-tissue-density-change-after-oophorectomy-in-brca-mutation-carrier-patients-using-visual-volumetric-analysis
#10
Augustin Lecler, Ariane Dunant, Suzette Delaloge, Delphine Wehrer, Tania Moussa, Olivier Caron, Corinne Balleyguier
OBJECTIVE: BRCA1/2 mutations account for 30-50% of hereditary breast cancers and bilateral oophorectomy is associated with a reduced risk of breast cancer (BC) in these patients. Breast density is a well-established BC risk factor and is also associated with increased risk in BRCA carriers. The aim of the study was to evaluate the impact of oophorectomy on mammographic breast density and to assess which method of breast density assessment is more sensitive to change over time. METHODS: Retrospective study of 50 BRCA1/2 patients who underwent bilateral oophorectomy and had at least a baseline and post-surgery mammogram...
November 28, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29172261/knowledge-of-evidence-based-cancer-risk-factors-remains-low-among-new-zealand-adults-findings-from-two-cross-sectional-studies-2001-and-2015
#11
Rosalina Richards, Bronwen McNoe, Ella Iosua, Anthony I Reeder, Richard Egan, Louise Marsh, Lindsay Robertson, Brett Maclennan, Anna TF Latu, Robin Quigg, Anne-Cathrine Petersen
Objective: Cancer risk reduction messages are a part of cancer control efforts around the world. The complex reality is that risk factors differ for different types of cancer, making clear communication of desired behavioural changes more difficult. This study aims to describe awareness of risk factors for breast, bowel, cervical, prostate and lung cancer and cutaneous melanoma among New Zealanders in 2014/15 and identify changes in awareness since 2001. Methods: Two national telephone surveys, the first (CAANZ01) conducted in 2001, included 438 adults (231 females and 207 males, 64% response rate)...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29165021/two-years-of-tamoxifen-or-no-adjuvant-systemic-therapy-for-patients-with-high-risk-breast-cancer-long-term-follow-up-of-the-copenhagen-breast-cancer-trial
#12
Maj-Britt Jensen, Jens Fabricius Krarup, Torben Palshof, Henning T Mouridsen, Bent Ejlertsen
BACKGROUND: The Copenhagen Breast Cancer Trial (CBCT) randomly assigned patients with early breast cancer to two years of tamoxifen or placebo and we evaluated the effect over the following four decades. PATIENT AND METHODS: Between 1975 and 1978, 327 patients with primary breast cancer were randomly assigned to two years of daily placebo or tamoxifen. Survival statistics was collected from the Danish Civil Registration System. RESULTS: The five-year invasive breast cancer recurrence (BCR) rate was 43...
November 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29158285/neoadjuvant-palbociclib-on-er-breast-cancer-n007-clinical-response-and-endopredict-value
#13
Louis Wc Chow, Satoshi Morita, Christopher Yc Chow, Wai Kuen Ng, Masakazu Toi
To test the efficacy of neoadjuvant palbociclib therapy and to evaluate its impact on cell cycle arrest and changes in EndoPredict (EP) scores before and after treatment. Postmenopausal women with histologically proven ER+ve, HER2-ve invasive breast cancer, 2cm or greater, were enrolled in an open-label, single arm study. Twenty eligible patients were given letrozole 2.5mg per day together with palbociclib 125mg per day for 3 out of 4 weeks in repeated cycles for 16 weeks (4 cycles) before surgery. The primary end-points were clinical response rates (cRR) and preoperative endocrine prognostic index (PEPI)...
November 20, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29144507/the-fragile-x-mental-retardation-protein-regulates-tumor-invasiveness-related-pathways-in-melanoma-cells
#14
Francesca Zalfa, Vincenzo Panasiti, Simone Carotti, Maria Zingariello, Giuseppe Perrone, Laura Sancillo, Laura Pacini, Flavie Luciani, Vincenzo Roberti, Silvia D'Amico, Rosa Coppola, Simona Osella Abate, Rosa Alba Rana, Anastasia De Luca, Mark Fiers, Valentina Melocchi, Fabrizio Bianchi, Maria Giulia Farace, Tilmann Achsel, Jean-Christophe Marine, Sergio Morini, Claudia Bagni
The fragile X mental retardation protein (FMRP) is lacking or mutated in patients with the fragile X syndrome (FXS), the most frequent form of inherited intellectual disability. FMRP affects metastasis formation in a mouse model for breast cancer. Here we show that FMRP is overexpressed in human melanoma with high Breslow thickness and high Clark level. Furthermore, meta-analysis of the TCGA melanoma data revealed that high levels of FMRP expression correlate significantly with metastatic tumor tissues, risk of relapsing and disease-free survival...
November 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29139223/dosimetric-effects-of-intrafractional-isocenter-variation-during-deep-inspiration-breath-hold-for-breast-cancer-patients-using-surface-guided-radiotherapy
#15
Malin Kügele, Anneli Edvardsson, Lovisa Berg, Sara Alkner, Carina Andersson Ljus, Sofie Ceberg
The aim of this study was to investigate potential dose reductions to the heart, left anterior descending coronary artery (LAD), and ipsilateral lung for left-sided breast cancer using visually guided deep inspiration breath-hold (DIBH) with the optical surface scanning system Catalyst™, and how these potential dosimetric benefits are affected by intrafractional motion in between breath holds. For both DIBH and free breathing (FB), treatment plans were created for 20 tangential and 20 locoregional left-sided breast cancer patients...
November 15, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29137948/analysis-of-tumor-biology-to-advance-cancer-health-disparity-research
#16
REVIEW
Cheryl Jacobs Smith, Tsion Zewdu Minas, Stefan Ambs
Cancer mortality rates in the US continue to decline. Reductions in tobacco use, uptake of preventive measures, adoption of early detection methods, and better treatments have resulted in improved cancer outcomes for men and women. Despite this progress, some population groups continue to experience an excessive cancer burden when compared with other population groups. One of the most prominent cancer health disparities exists in prostate cancer. Prostate cancer mortality rates are highest among men of African ancestry when compared with other men, both in the US and globally...
November 11, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29132555/considerations-in-testing-for-inherited-breast-cancer-predisposition-in-the-era-of-personalized-medicine
#17
REVIEW
Benjamin Powers, Tuya Pal, Christine Laronga
Technological advances realized through next-generation sequencing technologies coupled with the loss of the ability to patent genes have led to reduction in costs for genetic testing. As a result, more people are being identified with inherited breast cancer syndromes that may affect recommendations for surveillance and risk reduction. Surgeons, at the forefront for patients newly diagnosed with breast cancer, must keep current with the changing landscape of genetics to continue to provide appropriate counsel and care...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29125710/thiazolidinedione-therapy-and-breast-cancer-risk-in-diabetic-women-a-systematic-review-and-meta-analysis
#18
REVIEW
Rui Du, Lin Lin, Di Cheng, Yu Xu, Min Xu, Yuhong Chen, Weiqing Wang, Yufang Bi, Donghui Li, Jieli Lu
BACKGROUND: Rising experimental evidence suggests that thiazolidinediones (TZDs) exert a protective effect on breast cancer. However, studies concerning this issue were inconsistent and limited. Hence, we performed a meta-analysis with data from currently available studies to evaluate the effect of TZDs on breast cancer risk among diabetic women. METHODS: We comprehensively searched for all pertinent studies addressing TZDs use and breast cancer risk published before January 1, 2016 in PubMed, Clinical Trials and Cochrane library...
November 10, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29112471/screening-for-breast-cancer-in-women-age-75-years-and-older
#19
Cindy S Lee, Linda Moy, Bonnie N Joe, Edward A Sickles, Bethany L Niell
OBJECTIVE: Older women undergoing regular mammography experience significant reductions in breast cancer mortality, except in women with severe comorbidities or limited life expectancy. Optimizing screening strategies requires informed discussions of benefits and risks given each woman's health status. CONCLUSION: This article will review the benefits and risks of screening mammography in women older than 75 years within the context of life expectancy and comorbidities and summarize the current recommendations from professional organizations for screening mammography in older women...
November 7, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29108384/efficacy-safety-and-proper-dose-analysis-of-pegylated-granulocyte-colony-stimulating-factor-as-support-for-dose-dense-adjuvant-chemotherapy-in-node-positive-chinese-breast-cancer-patients
#20
Fan Zhang, RuiXia LingHu, XingYang Zhan, Ruisheng Li, Fan Feng, Xudong Gao, Lei Zhao, Junlan Yang
For high-risk breast cancer patients with positive axillary lymph nodes, dose-dense every-two-week epirubicin/cyclophosphamide-paclitaxel (ddEC-P) regimen is the optimal postoperative adjuvant therapy. However, this regimen is limited by the grade 3/4 neutropenia and febrile neutropenia (FN). There is an urgent need to explore the efficacy, safety and proper dosage of PEGylated granulocyte colony-stimulating factor (PEG-G-CSF) as support for ddEC-P in Chinese breast cancer patients with positive axillary lymph nodes...
October 3, 2017: Oncotarget
keyword
keyword
9787
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"