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https://www.readbyqxmd.com/read/28816953/peritumoral-decreased-uptake-area-of-gadoxetic-acid-enhanced-magnetic-resonance-imaging-and-tumor-recurrence-after-surgical-resection-in-hepatocellular-carcinoma-a-strobe-compliant-article
#1
Seung Kak Shin, Yun Soo Kim, Young Sup Shim, Seung Joon Choi, So Hyun Park, Dong Hae Jung, Oh Sang Kwon, Duck Joo Choi, Ju Hyun Kim
Recently, it has been suggested that peritumoral decreased uptake area (PDUA) in the hepatobiliary phase (HBP) of gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) was associated with vascular invasion in hepatocellular carcinoma (HCC). We aimed to investigate correlations between microvascular invasion and PDUA, and elucidate the predictability of PDUA for tumor recurrence after resection.We retrospectively analyzed clinicopathological and radiological data from 126 consecutive patients with single HCC ≤5 cm without macrovascular invasion who underwent preoperative Gd-EOB-DTPA-enhanced MRI and surgical resection...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28797107/jasplakinolide-induces-primary-cilium-formation-through-cell-rounding-and-yap-inactivation
#2
Tomoaki Nagai, Kensaku Mizuno
Primary cilia are non-motile cilia that serve as cellular antennae for sensing and transducing extracellular signals. In general, primary cilia are generated by cell quiescence signals. Recent studies have shown that manipulations to increase actin assembly suppress quiescence-induced ciliogenesis. To further examine the role of actin dynamics in ciliogenesis, we analyzed the effect of jasplakinolide (Jasp), a potent inducer of actin polymerization, on ciliogenesis. Unexpectedly, Jasp treatment induced ciliogenesis in serum-fed cells cultured at low density...
2017: PloS One
https://www.readbyqxmd.com/read/28794684/argyrella-richardsiae-a-new-species-of-melastomataceae-from-the-wet-miombo-woodlands-of-south-central-africa
#3
Marie Claire Veranso-Libalah, Robert Douglas Stone, Gudrun Kadereit
A new species from the wet miombo woodlands of Tanzania and Angola, Argyrella richardsiae Veranso-Libalah & G.Kadereit, sp. nov. (Melastomataceae, Melastomateae), is described and illustrated. Although the widespread Argyrella canescens also occurs in Tanzania and northeastern Angola, A. richardsiae is morphologically most similar to Argyrella bambutorum known only from the Northwest of Cameroon, but differs by its indumentum of glandular trichomes on the entire plant (versus a mixture of stellate and glandular trichomes in other species of Argyrella), leaf-blades with serrulate margins (versus entire margins in A...
2017: PhytoKeys
https://www.readbyqxmd.com/read/28791989/treatment-of-resistant-idiopathic-hiccups-with-pulse-radio-frequency-on-phrenic-nerve-and-gabapentin-a-case-report
#4
O Ozturk, E Yavuz, B Yazicioglu, B Uzuner
Hiccups affect life quality, career and family life when they become persistent. We present here a 54-year-old man who worked as a mason and a blacksmith with hiccups complaint for nearly one and a half years. In this period, he was admitted to emergency service ten times with fainting or almost fainting, cold sweating and hand stretching complaints. The patient expressed that he frequently threw up when he had hiccups and his social life was negatively affected. He reported that he was treated with baclofen, esomeprazole and hyoscine-n-butyl bromur without relief...
July 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28767325/evolutionary-relationships-and-cytotaxonomy-considerations-in-the-genus-pyrrhulina-characiformes-lebiasinidae
#5
Renata Luiza Rosa de Moraes, Luiz Antonio Carlos Bertollo, Manoela Maria Ferreira Marinho, Cassia Fernanda Yano, Terumi Hatanaka, Felipe Faix Barby, Waldo Pinheiro Troy, Marcelo de Bello Cioffi
Although fishes exhibit the greatest biodiversity among the vertebrates, a large percentage of this fauna is still underexplored on evolutionary cytogenetic questions, particularly the miniature species. The Lebiasinidae family is a particular example for such case. This study is the first one presenting differential cytogenetic methods, such as C-banding, repetitive DNAs mapping, comparative genomic hybridization (CGH), and whole chromosome painting in lebiasinid species. Pyrrhulina australis and Pyrrhulina aff...
August 2, 2017: Zebrafish
https://www.readbyqxmd.com/read/28766178/differential-regulation-of-il-1%C3%AE-and-il-6-release-in-murine-macrophages
#6
Seishiro Hirano, Quan Zhou, Akiko Furuyama, Sanae Kanno
Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1β release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome. However, the conversion of pro-IL-1β to its active form seems to depend on the macrophage cell types. In the present study, bone marrow-derived macrophages (BMM) and three murine macrophage cell lines, J774.1, J774A.1, and RAW264.7 were exposed to ATP or fibrous titanium dioxide (FTiO2) in the presence or absence of lipopolysaccharide (LPS), and the concentrations of IL-1β and IL-6 in both cell lysates and in the culture media were measured by immunoblotting to differentiate active form of IL-1β from pro-IL-1β...
August 1, 2017: Inflammation
https://www.readbyqxmd.com/read/28762848/healthcare-resource-utilization-and-costs-for-patients-with-pulmonary-arterial-hypertension-real-world-documentation-of-functional-class
#7
Robert Dufour, Janis Pruett, Nan Hu, Cassandra Lickert, Stephen Stemkowski, Yuen Tsang, Daniel Lane, William Drake
BACKGROUND AND AIMS: Pulmonary arterial hypertension (PAH) is a rare medical disease in which patients experience increased pulmonary vascular resistance (PVR) and pulmonary arterial pressure that can result in remodeling of the pulmonary vasculature and heart and eventually lead to right heart failure and death. As PAH progresses, patients become unable to perform even routine daily tasks without severe shortness of breath (dyspnea), fatigue, dizziness, and fainting (syncope). Treatment strategies largely depend on assessment of an individual patient's WHO Functional Class...
August 1, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28762352/a-comparative-study-to-associate-the-presence-of-neonatal-line-in-deciduous-teeth-of-infants-with-the-occurrence-of-live-birth
#8
Shruti Srinivasan, Prashanth Sadashiva Murthy, Seema Deshmukh, N M Shamsundar
CONTEXT: The prominent striae of retzius corresponding to the occurrence of live birth is known as the neonatal line (NNL). The very presence of this line indicates the exposure of the infant to the stressful event of birth. AIMS: The study was aimed at locating the NNL in the developing primary teeth of the neonate and associating the presence of NNL to the occurrence of live birth. MATERIALS AND METHODS: The donated bodies of the neonates were taken, and a surgical incision was made along the crest of the alveolar ridge in the maxillary anterior region, enabling the careful removal of the tooth germs from within the jaw segment...
July 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28753348/observation-of-quasichanneling-oscillations
#9
T N Wistisen, R E Mikkelsen, U I Uggerhøj, U Wienands, T W Markiewicz, S Gessner, M J Hogan, R J Noble, R Holtzapple, S Tucker, V Guidi, A Mazzolari, E Bagli, L Bandiera, A Sytov
We report on the first experimental observations of quasichanneling oscillations, recently seen in simulations and described theoretically. Although above-barrier particles penetrating a single crystal are generally seen as behaving almost as in an amorphous substance, distinct oscillation peaks nevertheless appear for particles in that category. The quasichanneling oscillations were observed at SLAC National Accelerator Laboratory by aiming 20.35 GeV positrons and electrons at a thin silicon crystal bent to a radius of R=0...
July 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28741420/outreach-syncope-clinic-managed-by-a-nurse-practitioner-outcome-and-cost-effectiveness
#10
Mohamed H Hamdan, Kathleen E Walsh, Michele Brignole, Jamie Key
Introduction The purpose of this study was to assess the clinical and financial outcomes of a novel outreach syncope clinic. Methods We compared the clinical outcome of the Faint and Fall Clinic at the American Center (January-June 2016) with that of the University of Wisconsin Health and Clinics Faint and Fall Clinic (January 2013-December 2014). The American Center-Faint and Fall Clinic is run solely by a nurse practitioner, assisted by online faint-decision software and consultancy of a faint specialist through video-conferencing...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28737202/-euglycemic-ketosis-in-an-adolescent-with-type-1-diabetes-on-insulin-and-dapaglifozin-case-report
#11
Marcia Pereyra A, Cristhian Ramírez, Rossana Román
Dapagliflozin, an insulin-independent sodium-glucose cotransporter 2 inhibitor (SGLT2-I) induces glycosuria and reduces hyperglycemia in adults with type 2 diabetes. OBJECTIVE: To present an “euglycemic” diabetic ketosis in an adolescent with type 1 diabetes (T1D) receiving dapagliflozin, to alert about the risk of a drug not approved in children nor in T1D. CASE REPORT: A 17 years old adolescent with T1D during 9 years, was started on dapagliflozin 10 mg / day to reduce insulin dose and weight...
June 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28737117/prevalence-and-correlates-of-traumatic-brain-injury-tbi-in-older-adults-results-from-the-well-being-of-the-singapore-elderly-wise-study
#12
Laxman Cetty, Edimansyah Abdin, Janhavi Ajit Vaingankar, Anitha Jeyagurunathan, Boon Yiang Chua, Louisa Picco, Martin Prince, Siow Ann Chong, Mythily Subramaniam
BACKGROUND: Older adults are among the most susceptible to sustain traumatic brain injury (TBI). The study aimed to determine the (1) prevalence of TBI among older adults in Singapore, and (2) socio-demographic, lifestyle, and clinical correlates of TBI. METHODS: Data were extracted from the cross-sectional, Well-being of the Singapore Elderly (WiSE) study. The study included 2,565 participants aged 60 years and above (Mean = 72.75, SD = 9.54). Information on TBI, socio-demographic, and lifestyle factors were collected using participant self-report and verified with the informant report where necessary...
July 24, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28734237/the-spider-and-the-snake-a-psychometric-study-of-two-phobias-and-insights-from-the-hungarian-validation
#13
Andras N Zsido
Specific phobias-particularly zoophobias-are prevalent worldwide and can have fairly dramatic health consequences. Self-report measurements play a crucial role in phobia research studies; thus, it is important to have a reliable tool in different languages. The present investigation examined the psychometric properties of the Hungarian version of two commonly used measures of fear: the Spider Phobia Questionnaire (i.e. SPQ) and the Snake Questionnaire (i.e. SNAQ). The SPQ and SNAQ scores both demonstrated excellent reliability, including a test-retest over a 4-week period...
July 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28724919/generally-applicable-transformation-protocols-for-fluorescent-nanodiamond-internalization-into-cells
#14
Simon R Hemelaar, Kiran J van der Laan, Sophie R Hinterding, Manon V Koot, Else Ellermann, Felipe P Perona-Martinez, David Roig, Severin Hommelet, Daniele Novarina, Hiroki Takahashi, Michael Chang, Romana Schirhagl
Fluorescent nanodiamonds (FNDs) are promising nanoprobes, owing to their stable and magnetosensitive fluorescence. Therefore they can probe properties as magnetic resonances, pressure, temperature or strain. The unprecedented sensitivity of diamond defects can detect the faint magnetic resonance of a single electron or even a few nuclear spins. However, these sensitivities are only achieved if the diamond probe is close to the molecules that need to be detected. In order to utilize its full potential for biological applications, the diamond particle has to enter the cell...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719088/understanding-and-managing-the-risk-of-head-impact-from-in-hospital-falls-a-cross-sectional-analysis-of-data-from-166-public-hospitals
#15
Satyan R Chari, Paul Varghese, Rebecca A R Bell, Kate Smith, Terry P Haines
BACKGROUND: Falls are a leading cause of preventable harm in the hospitalized elderly, and head impacts (HIs) can be a precursor to serious injury. The aim of this study was to examine if the risk of fall-related HI can be explained by incident characteristics. METHODS: All reported falls across public hospital facilities in the state of Queensland, Australia, over a 2-year period were analyzed using univariate and multiple logistic regression. RESULTS: In all, 650 instances of HI were reported across 24 218 falls...
July 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/28711557/postprandial-hypoglycemia-complication-of-peptic-ulcer-surgery
#16
Adnan Haider, James K Burks, H I Cheema, Angel Tejada
OBJECTIVE: Billroth II procedures (gastrojejunostomy with vagotomy) are seldom performed now, but were popular before the advent of histamine 2 (H2) receptor blockers and proton pump inhibitors (PPIs). Such procedures can be a cause of late postprandial hypoglycemia. METHOD: Formal evaluation, discussion of postprandial hypoglycemia. RESULTS: We present a case of an 85-year-old man who presented to the Endocrinology clinic with a complaint of "fainting spells following large meals...
July 12, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28708727/splenic-involvement-in-disseminated-mycobacterium-avium-intracellulare-infection-magnetic-resonance-imaging-findings
#17
Haley Clark, Gaurav Khatri, Payal Kapur, Ivan Pedrosa
We report the imaging findings of a patient with disseminated Mycobacterium avium-intracellulare complex presenting with multiple splenic lesions incompletely characterized on computed tomography in whom magnetic resonance imaging helped narrow the differential diagnosis. We discuss the magnetic resonance imaging findings suggesting the diagnosis, including the presence of focal susceptibility artifact within the lesions (ie, signal drop on T1 in-phase imaging), marked hypointensity on diffusion-weighted imaging, and faint progressive peripheral enhancement after contrast administration...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28706436/the-presence-of-kynurenine-aminotransferases-in-the-human-cornea-evidence-from-bioinformatics-analysis-of-gene-expression-and-immunohistochemical-staining
#18
Anna Matysik-Woźniak, Anselm Jünemann, Waldemar A Turski, Artur Wnorowski, Krzysztof Jóźwiak, Roman Paduch, Etsuo Okuno, Joanna Moneta-Wielgoś, Tomasz Chorągiewicz, Ryszard Maciejewski, Robert Rejdak
PURPOSE: Kynurenine aminotransferases (KATs) catalyze the synthesis of kynurenic acid (KYNA), a compound of significant biological activity. The aim of this study is to investigate the presence and distribution of KAT immunoreactivity in the healthy human cornea. METHODS: Data on gene expression in human eye structures were extracted from public microarray experiments using Genevestigator software. Immunohistochemistry was conducted using polyclonal antibodies against KAT I, II, and III on sections of eight enucleated eyes from patients with choroidal melanoma...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28698503/cd15s-cd62e-interaction-mediates-the-adhesion-of-non-small-cell-lung-cancer-cells-on-brain-endothelial-cells-implications-for-cerebral-metastasis
#19
Samah A Jassam, Zaynah Maherally, James R Smith, Keyoumars Ashkan, Federico Roncaroli, Helen L Fillmore, Geoffrey J Pilkington
Expression of the cell adhesion molecule (CAM), Sialyl Lewis X (CD15s) correlates with cancer metastasis, while expression of E-selectin (CD62E) is stimulated by TNF-α. CD15s/CD62E interaction plays a key role in the homing process of circulating leukocytes. We investigated the heterophilic interaction of CD15s and CD62E in brain metastasis-related cancer cell adhesion. CD15s and CD62E were characterised in human brain endothelium (hCMEC/D3), primary non-small cell lung cancer (NSCLC) (COR-L105 and A549) and metastatic NSCLC (SEBTA-001 and NCI-H1299) using immunocytochemistry, Western blotting, flow cytometry and immunohistochemistry in human brain tissue sections...
July 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28693455/fainting-fanconi-syndrome-clarified-by-proxy-a-case-report
#20
Stephen Benedict Walsh, Robert Unwin, Robert Kleta, William Van't Hoff, Paul Bass, Khalid Hussain, Sian Ellard, Detlef Bockenhauer
BACKGROUND: Rare diseases may elude diagnosis due to unfamiliarity of the treating physicians with the specific disorder. Yet, advances in genetics have tremendously enhanced our ability to establish specific and sometimes surprising diagnoses. CASE PRESENTATION: We report a case of renal Fanconi syndrome associated with intermittent hypoglycemic episodes, the specific cause for which remained elusive for over 30 years, despite numerous investigations, including three kidney and one liver biopsy...
July 11, 2017: BMC Nephrology
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