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https://www.readbyqxmd.com/read/29142365/superscan-on-methylene-diphosphonate-skeletal-scintigraphy-in-prostatic-adenocarcinoma-a-common-finding-but-rare-etiology
#1
Piyali Chatterjee, Anirban Mukherjee, Deepanjan Mitra, Amit Nautiyal, Anindya Roy
Excessive skeletal radioisotope uptake in relation to soft tissues along with absent or faint activity in the genitourinary tract on skeletal scintigraphy is known as a "superscan." Prostate cancer is the most common cause of superscan in skeletal scintigraphy due to diffuse skeletal metastases. However, prostate cancer may cause secondary renal osteodystrophy leading to metabolic superscan also. Differentiating between these two entities are important as treatment options are different. We, hereby, describe a case of prostatic adenocarcinoma presented with metabolic superscan on methylene diphosphonate skeletal scintigraphy and demonstrate the utility of single emission computed tomography-computed tomography in differentiating between two entities...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29134540/acute-connexin43-temporal-and-spatial-expression-in-response-to-ischemic-stroke
#2
Moises Freitas-Andrade, Jennifer She, John Bechberger, Christian C Naus, Wun Chey Sin
Connexin43 (Cx43) gap junctions expressed in astrocytes can significantly impact neuronal survival in stroke. However, little is known regarding Cx43 spatial and temporal expression during the initial stages of brain ischemia. Using immunohistochemistry and Western blot analysis, we examined Cx43 spatial and temporal expression as a function of neuronal injury within the first 24 h after permanent middle cerebral artery occlusion (pMCAO). Western blot analysis showed a significant increase in Cx43 protein expression in the core ischemic area at 2 and 3 h after pMCAO...
November 13, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29133991/nipponnemertes-incainca-sp-n-adoption-of-the-new-taxonomic-proposal-for-nemerteans-nemertea-cratenemertidae
#3
Jaime Gonzalez-Cueto, Lyda R Castro, Sigmer Quiroga
A new species Nipponemertes incainca is described from the intertidal zone of Santa Marta, Colombia. A new recent approach based on both morphological and molecular characters is applied for the description. The main characteristics of the species are: red color, head shield-shaped with a mid-dorsal cephalic ridge, furrows pre-cerebral inconspicuous with few faint ridges orthogonal to furrow axis, two irregular groups of eyespots situated at lateral margins in precerebral cephalic region, proboscis provided with papillae and 12 nerves, stylet smooth supported on an oval basis, and two pouches containing 3-4 accessory stylets each...
2017: ZooKeys
https://www.readbyqxmd.com/read/29119942/18f-faza-pet-ct-in-the-preoperative-evaluation-of-nsclc-comparison-with-18f-fdg-and-immunohistochemistry
#4
Paola Mapelli, Valentino Bettinardi, Federico Fallanca, Elena Incerti, Antonia Compierchio, Francesca Rossetti, Angela Coliva, Annarita Savi, Claudio Doglioni, Giampiero Negri, Luigi Gianolli, Maria Picchio
PURPOSE: To assess the capability of 18F-FAZA PET/CT in identifying intratumoral hypoxic areas in early and locally advanced non-small cell lung cancer (NSCLC) patients and to compare 18F-FAZA PET/CT with 18F-FDG PET/CT and histopathological biomarkers and to investigate whether the assessment of tumour to blood (T/B) and tumour to muscle (T/M) ratios provides comparable information regarding the hypoxic fractions of the tumour. MATERIALS AND METHODS: Seven patients with NSCLC were prospectively enrolled (3 men, 4 women; median age: 71 years; range 63-80)...
November 8, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29114435/hepatitis-c-virus-genie-a-web-2-0-interpretation-and-analytics-platform-for-the-versant-hepatitis-c-virus-genotype-line-probe-assay-version-2-0
#5
Alex M Dussaq, Abha Soni, Christopher Willey, Seung L Park, Shuko Harada
Context: Hepatitis C virus (HCV) genotyping at our institution is performed using the Versant HCV genotype 2.0 Line Probe Assay (LiPA). The last steps of this procedure are manual, laborious, and error-prone process that involves the comparison of the banding pattern on a test strip to a physical reference table. Aim: We developed a web-based HCV genotype interpretation platform that utilizes a scanned image to generate the genotypes, thus minimizing interpretation time and reducing error...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29111992/cardiovascular-and-cerebral-hemodynamics-in-asymptomatic-healthy-subjects-with-without-abnormal-head-up-tilt-test-versus-recurrent-fainters
#6
Antonio González-Hermosillo, Manuel Sierra-Beltrán, Ulises López-Peña, Andrei Kostin, Guadalupe Hernández-Pacheco, Claudia Lerma
PURPOSE: The aim of this study was to compare hemodynamic and autonomic responses during head-up tilt test (HUTT) between healthy volunteers and patients with a history of fainting and confirmed vasovagal syncope. We hypothesize that the autonomic and hemodynamic physiologic responses remain intact during orthostatic stress in people without previous fainting and negative HUTT, but deteriorate similarly in patients with recurrent vasovagal syncope and in asymptomatic healthy subjects who develop a vasovagal response during HUTT...
October 27, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29094694/spectroscopic-identification-of-r-process-nucleosynthesis-in-a-double-neutron-star-merger
#7
E Pian, P D'Avanzo, S Benetti, M Branchesi, E Brocato, S Campana, E Cappellaro, S Covino, V D'Elia, J P U Fynbo, F Getman, G Ghirlanda, G Ghisellini, A Grado, G Greco, J Hjorth, C Kouveliotou, A Levan, L Limatola, D Malesani, P A Mazzali, A Melandri, P Møller, L Nicastro, E Palazzi, S Piranomonte, A Rossi, O S Salafia, J Selsing, G Stratta, M Tanaka, N R Tanvir, L Tomasella, D Watson, S Yang, L Amati, L A Antonelli, S Ascenzi, M G Bernardini, M Boër, F Bufano, A Bulgarelli, M Capaccioli, P Casella, A J Castro-Tirado, E Chassande-Mottin, R Ciolfi, C M Copperwheat, M Dadina, G De Cesare, A Di Paola, Y Z Fan, B Gendre, G Giuffrida, A Giunta, L K Hunt, G L Israel, Z-P Jin, M M Kasliwal, S Klose, M Lisi, F Longo, E Maiorano, M Mapelli, N Masetti, L Nava, B Patricelli, D Perley, A Pescalli, T Piran, A Possenti, L Pulone, M Razzano, R Salvaterra, P Schipani, M Spera, A Stamerra, L Stella, G Tagliaferri, V Testa, E Troja, M Turatto, S D Vergani, D Vergani
The merger of two neutron stars is predicted to give rise to three major detectable phenomena: a short burst of γ-rays, a gravitational-wave signal, and a transient optical-near-infrared source powered by the synthesis of large amounts of very heavy elements via rapid neutron capture (the r-process). Such transients, named 'macronovae' or 'kilonovae', are believed to be centres of production of rare elements such as gold and platinum. The most compelling evidence so far for a kilonova was a very faint near-infrared rebrightening in the afterglow of a short γ-ray burst at redshift z = 0...
November 2, 2017: Nature
https://www.readbyqxmd.com/read/29092897/careers-at-biotech-start-ups-and-in-entrepreneurship
#8
REVIEW
Susan Froshauer
The world of biotechnology "start-ups" and entrepreneurship offers exciting new avenues for driving state-of-the-art research using an arsenal of multidisciplinary skills, whether your role is as part of a team or as a leader. Although traditionally these positions may not be as secure as those offered by some of the larger companies, the small start-up culture provides opportunities for contributing at many levels to a wide range of responsibilities: from scientific discovery to delivery of proof of concept and intellectual property; from analysis of market opportunities and competitive intelligence to creation of time lines and business plans for a first product...
November 1, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/29076173/fear-of-donation-related-stimuli-is-reported-across-different-levels-of-donation-experience
#9
Christopher R France, Janis L France
BACKGROUND: This study aimed to characterize the extent of donation-related fears among donors with different levels of donation experience. STUDY DESIGN AND METHODS: A sample of 1054 recent donors (48.3% female; mean ± SD age 33.1 ± 9.8 years) completed an anonymous, online survey of their fear of donation-related stimuli, including blood, needles, pain, and fainting. Respondents also provided information regarding demographics, pain, and vasovagal symptoms associated with their recent donation and confidence and intention with respect to a future donation...
October 26, 2017: Transfusion
https://www.readbyqxmd.com/read/29049725/cd11b-and-cd200-on-circulating-monocytes-differentiate-two-angiographic-subtypes-of-polypoidal-choroidal-vasculopathy
#10
COMPARATIVE STUDY
Yousif Subhi, Marie Krogh Nielsen, Christopher Rue Molbech, Akio Oishi, Amardeep Singh, Mogens Holst Nissen, Torben Lykke Sørensen
Purpose: To investigate surface expression of CD11b and CD200 on circulating monocytes in patients with polypoidal choroidal vasculopathy (PCV). Methods: This was a prospective case-control study of patients with PCV (n = 27), age-matched healthy controls (n = 27), and patients with neovascular AMD (n = 49). All participants underwent a comprehensive ocular examination. Fluorescein and indocyanine green angiography were performed in patients suspected of neovascular AMD or PCV...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29047471/teaching-rainbows-with-simulations-revisiting-minnaert-s-lab-experiment
#11
Francisco L Naranjo-Correa, Guadalupe Martinez-Borreguero, Angel Luis Pérez-Rodriguez, Pedro J Pardo-Fernandez, Maria Isabel Suero-Lopez
This work presents an educational simulation to support students' learning about the formation of the rainbow. The main aim of the simulation is to provide our students with a didactic tool in addition to their traditional laboratory practice, which can be easily implemented in e-learning teaching platforms. A system consisting of a flask filled with water and a screen with a rounded aperture placed between the sun and the flask was simulated; this way a faint rainbow was seen on the simulated screen. The interactive nature of the simulation allowed the students to perform some alterations that would be impossible to do in the real world; thus, the observed rainbow deviated from the simplest model...
July 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29042987/upregulation-of-yes-associated-protein-and-transcriptional-co-activator-with-pdz-binding-motif-influences-the-behavior-of-lovo-human-colon-adenocarcinoma-cells
#12
Yu Li, Lan Li, Min Zhu, Limin Ye, Qian Yang
The present study aimed to investigate the role of Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) in the LOVO human colon adenocarcinoma cell line and explore the underlying mechanisms. First, the expression levels of YAP and TAZ were detected in LOVO cells using reverse-transcription quantitative PCR, and the results suggested that YAP and TAZ were faintly expressed in LOVO cells. To investigate the exact role of YAP and TAZ in LOVO cells, stable YAP- and/or TAZ-overexpressing LOVO cell lines were established using YAP and/or TAZ expression plasmids...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29041699/photon-heterodyning
#13
Youhei Okawa, Fuminori Omura, Yuhsuke Yasutake, Susumu Fukatsu
Single-photon interference experiments are attempted in the time domain using true single-photon streams. Self-heterodyning beats are clearly observed by letting the field associated with a single photon interfere with itself on a field-quadratic detector, which is a time analogue of Young's two-slit interference experiment. The temporal first-order coherence of single-photon fields, i.e., transient interference fringes, develops as cumulative detection events are mapped point-by-point onto a virtual capture frame by properly correlating the time-series data...
August 21, 2017: Optics Express
https://www.readbyqxmd.com/read/29041260/compact-acousto-optic-imaging-spectro-polarimeter-for-mineralogical-investigations-in-the-near-infrared
#14
Denis A Belyaev, Konstantin B Yushkov, Sergey P Anikin, Yuri S Dobrolenskiy, Aleksander Laskin, Sergey N Mantsevich, Vladimir Ya Molchanov, Sergey A Potanin, Oleg I Korablev
Spectral imaging in the near infrared is a promising method for mineralogy analysis, in particular well-suited for airless celestial objects or those with faint atmospheres. Additional information about structure and composition of minerals can be obtained using spectral polarimetry with high spatial resolution. We report design and performance of laboratory prototype for a compact near infrared acousto-optic imaging spectro-polarimeter, which may be implemented for remote or close-up analysis of planetary surfaces...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29039551/upregulation-of-rho7-in-the-temporal-lobe-tissue-of-humans-with-intractable-epilepsy
#15
Xinglong Yang, Baiyuan Yang, Haonan Li, Hui Ren
Patients with intractable epilepsy (IE) exhibit an increased risk of premature death, psychosocial dysfunction and decreasing quality of life. The present study aimed to investigate the alteration in the expression of Rho7 in brain tissue from patients with IE, and to examine the association between Rho7 protein expression and IE. Temporal lobe samples were collected from the temporal lobes of 33 patients with IE patients and 10 age‑ and gender‑matched histologically healthy controls. Immunohistochemical staining was conducted to assess the number of Rho7‑positive cells...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038780/pulmonary-ossification-and-microlithiasis-in-a-bitch-with-multicentric-mammary-tumors
#16
Mahir A G Kubba
Microliths and ossification were found in the lungs of a 12-year-old bitch suffering from compound mammary gland tumor which has disseminated in the inguinal lymph node glands and the lungs. Pulmonary ossification appeared grossly as irregular stony sharp particles which infiltrated the lung tissue and were readily recognizable from under the pleura as grayish sharp protruding particles. Microscopic examination revealed the existence of intra-alveolar single or multilobular particles of ossification which are formed of lamellated osseous substance with osteocytes in lacunae...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/29025675/acetal-linked-pegylated-paclitaxel-prodrugs-forming-free-paclitaxel-loaded-ph-responsive-micelles-with-high-drug-loading-capacity-and-improved-drug-delivery
#17
Da Huang, Yaping Zhuang, Hong Shen, Fei Yang, Xing Wang, Decheng Wu
Endosomal pH-responsive micellar nanoparticles were prepared by self-assembly of an amphiphilic poly(ethylene glycol)-acetal-paclitaxel (PEG-acetal-PTX) prodrug, and free PTX could be encapsulated in the hydrophobic core of the nanoparticles. These nanoparticles exhibited excellent storage stability for over 6months under normal conditions, but disassembled quickly in response to faintly acidic environment. Incorporating physical encapsulation and chemical conjugation, the PTX concentration in the nanoparticles solution could reach as high as 3665μg/mL, accompanying with a high drug loading capacity of 60...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29023704/gabaa-receptor-subunits-in-the-human-amygdala-and-hippocampus-immunohistochemical-distribution-of-7-subunits
#18
Harald Stefanits, Ivan Milenkovic, Nina Mahr, Ekaterina Pataraia, Johannes A Hainfellner, Gabor G Kovacs, Werner Sieghart, Deniz Yilmazer-Hanke, Thomas Czech
GABAergic neurotransmission in the amygdala contributes to the regulation of emotional processes in anxiety, stress, reward, mnestic functions, addiction, and epilepsy. Species-specific differences in the distribution and composition of GABAA receptors may account for distinct effects and side-effects of GABAergic agents. However, data on the distribution and composition of GABAA receptors in the human amygdala are lacking. Here, the expression of GABAA receptor subunits α1, α2, α3, α5, β2, β2/3 and γ2 was studied in the human amygdala using immunohistochemistry...
October 12, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29019068/early-epithelial-complications-of-accelerated-trans-epithelial-corneal-crosslinking-in-treatment-of-keratoconus-a-case-series
#19
Sharon S W Chow, Tommy C Y Chan, Ian Y H Wong, Michelle C Y Fan, Jimmy S M Lai, Alex L K Ng
BACKGROUND: To report a case series of early postoperative complications following combined accelerated corneal crosslinking (CXL) and trans-epithelial technique in keratoconus. CASE PRESENTATIONS: Eleven eyes underwent accelerated trans-epithelial CXL (18 mW/cm(2) for 5 min). Seven eyes (64%) developed complications in the first week postoperatively. Five eyes had large epithelial defects, and two eyes were complicated with diffuse punctate epithelial erosions...
October 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29016520/episcleral-venous-outflow-a-potential-outcome-marker-for-istent-surgery
#20
Cristina Bostan, Paul Harasymowycz
PURPOSE: (1) To propose the use of episcleral venous outflow (EVO) as an outcome marker of iStent surgery, and an EVO grading scale. (2) To determine the association of EVO with: (a) postoperative intraocular pressure (IOP) and medication burden; (b) iStent patency status. PATIENTS AND METHODS: Retrospective cohort study including 151 glaucomatous eyes having undergone iStent-phacoemulsification surgery. Demographic and preoperative data (IOP, number of anti-glaucoma medications, glaucoma type and stage, maximal IOP) were collected...
October 9, 2017: Journal of Glaucoma
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