Benjamin Kumwenda, Rocío Canals, Alexander V Predeus, Xiaojun Zhu, Carsten Kröger, Caisey Pulford, Nicolas Wenner, Lizeth Lacharme Lora, Yan Li, Siân V Owen, Dean Everett, Karsten Hokamp, Robert S Heyderman, Philip M Ashton, Melita A Gordon, Chisomo L Msefula, Jay C D Hinton
Invasive non-typhoidal Salmonella (iNTS) disease is a serious bloodstream infection that targets immune-compromised individuals, and causes significant mortality in sub-Saharan Africa. Salmonella enterica serovar Typhimurium ST313 causes the majority of iNTS in Malawi. We performed an intensive comparative genomic analysis of 608 S . Typhimurium ST313 isolates dating between 1996 and 2018 from Blantyre, Malawi. We discovered that following the arrival of the well-characterized S . Typhimurium ST313 lineage 2 in 1999, two multidrug-resistant variants emerged in Malawi in 2006 and 2008, designated sublineages 2...
2024: Microlife