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https://www.readbyqxmd.com/read/28538412/biomarkers-of-unstable-angina-pectoris-and-yangxin-decoction-intervention-an-exploratory-metabonomics-study-of-blood-plasma
#1
Xiao-Hong Yu, Jing Sun, Yan Wang, Ya-Bin Zhou
BACKGROUND: This study aimed to explore the related metabolic biomarkers and to observe the effects of Yangxin Decoction (YXD) on plasma metabolism of patients with unstable angina (UA). METHODS: In total, 10 patients with UA (intervention group) and 10 healthy participants (control group) were recruited for this study from January 2009 to December 2010. Plasma samples from both groups were analyzed using liquid chromatography mass spectrometry (LC-MS). Principle component analysis (PCA) and partial least squares (PLS) were used to explore the correlations between metabolic markers in patients with UA...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28535421/differentiation-of-crataegus-spp-guided-by-nuclear-magnetic-resonance-spectrometry-with-chemometric-analyses
#2
Jensen A Lund, Paula N Brown, Paul R Shipley
For compliance with US Current Good Manufacturing Practice regulations for dietary supplements, manufacturers must provide identity of source plant material. Despite the popularity of hawthorn as a dietary supplement, relatively little is known about the comparative phytochemistry of different hawthorn species, and in particular North American hawthorns. The combination of NMR spectrometry with chemometric analyses offers an innovative approach to differentiating hawthorn species and exploring the phytochemistry...
May 20, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28534842/rapid-prediction-of-moisture-content-in-intact-green-coffee-beans-using-near-infrared-spectroscopy
#3
Adnan Adnan, Dieter von Hörsten, Elke Pawelzik, And Daniel Mörlein
Moisture content (MC) is one of the most important quality parameters of green coffee beans. Therefore, its fast and reliable measurement is necessary. This study evaluated the feasibility of near infrared (NIR) spectroscopy and chemometrics for rapid and non-destructive prediction of MC in intact green coffee beans of both Coffeaarabica (Arabica) and Coffeacanephora (Robusta) species. Diffuse reflectance (log 1/R) spectra of intact beans were acquired using a bench top Fourier transform NIR instrument. MC was determined gravimetrically according to The International Organization for Standardization (ISO) 6673...
May 19, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28533478/real-time-near-infrared-raman-spectroscopy-for-the-diagnosis-of-nasopharyngeal-cancer
#4
Lim Chwee Ming, Nagaraja Rao Gangodu, Thomas Loh, Wei Zheng, Jianfeng Wang, Kan Lin, Huang Zhiwei
Near-infrared (NIR) Raman spectroscopy has been investigated as a tool to differentiate nasopharyngeal cancer (NPC) from normal nasopharyngeal tissue in an ex-vivo setting. Recently, we have miniaturized the fiber-optic Raman probe to investigate its utility in real time in-vivo surveillance of NPC patients. A posterior probability model using partial linear square (PLS) mathematical technique was constructed to verify the sensitivity and specificity of Raman spectroscopy in diagnosing NPC from post-irradiated and normal tissue using a diagnostic algorithm from three significant latent variables...
May 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28530582/proton-transfer-reaction-mass-spectrometry-ptr-ms-for-the-authentication-of-regionally-unique-south-african-lamb
#5
Sara W Erasmus, Magdalena Muller, Martin Alewijn, Alex H Koot, Saskia M van Ruth, Louwrens C Hoffman
The volatile fingerprints of South African lamb meat and fat were measured by proton-transfer mass spectrometry (PTR-MS) to evaluate it as an authentication tool. Meat and fat of the Longissimus lumborum (LL) of lambs from six different regions were assessed. Analysis showed that the volatile fingerprints were affected by the origin of the meat. The classification of the origin of the lamb was achieved by examining the calculated and recorded fingerprints in combination with chemometrics. Four different partial least squares discriminant analysis (PLS-DA) models were fitted to the data to classify lamb meat and fat samples into "region of origin" (six different regions) and "origin" (Karoo vs...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28525862/application-of-nirs-coupled-with-pls-regression-as-a-rapid-non-destructive-alternative-method-for-quantification-of-kba-in-boswellia-sacra
#6
Ahmed Al-Harrasi, Najeeb Ur Rehman, Fazal Mabood, Muhammaed Albroumi, Liaqat Ali, Javid Hussain, Hidayat Hussain, René Csuk, Abdul Latif Khan, Tanveer Alam, Saif Alameri
In the present study, for the first time, NIR spectroscopy coupled with PLS regression as a rapid and alternative method was developed to quantify the amount of Keto-β-Boswellic Acid (KBA) in different plant parts of Boswellia sacra and the resin exudates of the trunk. NIR spectroscopy was used for the measurement of KBA standards and B. sacra samples in absorption mode in the wavelength range from 700-2500nm. PLS regression model was built from the obtained spectral data using 70% of KBA standards (training set) in the range from 0...
May 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28525713/identification-and-validation-of-sensory-active-compounds-from-data-driven-research-a-flavoromics-approach
#7
Ian Ronningen, Michelle Miller, Youlin Xia, Devin G Peterson
In the current study significant LC/MS features, from multivariate analysis (MVA) models developed using untargeted chemical fingerprinting to characterize flavor changes in extracts of citrus fruits related to aging, were further isolated and analyzed for sensory relevant information, followed by structural elucidation of flavor actives. The top ten statistical features from two MVA approaches, partial least squares data analysis (PLS-DA) and Random Forrest (RF), were purified to approximately 70% via multi-dimensional liquid chromatography-mass directed fractionation to screen for sensory activity...
May 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28514717/quantification-of-active-ingredients-in-semi-solid-pharmaceutical-formulations-by-near-infrared-spectroscopy
#8
Lisa B Schlegel, Manfred Schubert-Zsilavecz, Mona Abdel-Tawab
Near infrared (NIR) spectroscopy is increasingly gaining significance in the pharmaceutical industry for quality and in-process control. However, the potential of this method for quantitative quality control in pharmacies has long been neglected and little data is available on its application in analysis of creams and ointments. This study evaluated the applicability of NIR spectrometer with limited wavelength range (1000-1900nm) for quantitative quality control of six different dermatological semi-solid pharmaceutical preparations...
May 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28508191/investigations-of-severity-level-measurements-for-diabetic-macular-oedema-using-machine-learning-algorithms
#9
S Murugeswari, R Sukanesh
BACKGROUND: The macula is an important part of the human visual system and is responsible for clear and colour vision. Macular oedema happens when fluid and protein deposit on or below the macula of the eye and cause the macula to thicken and swell. Normally, it occurs due to diabetes called diabetic macular oedema. Diabetic macular oedema (DME) is one of the main causes of visual impairment in patients. AIM: The aims of the present study are to detect and localize abnormalities in blood vessels with respect to macula in order to prevent vision loss for the diabetic patients...
May 15, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28507920/passenger-lymphocyte-syndrome-pls-a-single-center-retrospective-analysis-of-minor-abo-incompatible-liver-transplants
#10
Sévérine de Bruijn, Ester Philipse, Marie Madeleine Couttenye, Bart Bracke, Dirk Ysebaert, Peter Michielsen, Sven Francque, Thomas Vanwolleghem, Anke Verlinden
Background and Aims: Due to the shortage of donor livers, minor ABO-incompatible liver transplantations are commonly performed. Together with the allograft, immunocompetent B-lymphocytes, called passenger lymphocytes, are transplanted. In case of minor ABO-incompatibility, these passenger lymphocytes produce antibodies directed towards the recipient's red blood cells, which causes immune-mediated hemolysis, also known as the passenger lymphocyte syndrome (PLS). Although this is a self-limiting disorder, serious complications can occur, including graft failure...
March 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28504472/thoughtflow-standards-and-tools-for-provenance-capture-and-workflow-definition-to-support-model-informed-drug-discovery-and-development
#11
J J Wilkins, Pls Chan, J Chard, G Smith, M K Smith, M Beer, A Dunn, C Flandorfer, C Franklin, R Gomeni, L Harnisch, R Kaye, S Moodie, M L Sardu, E Wang, E Watson, K Wolstencroft, Sya Cheung
Pharmacometric analyses are complex and multifactorial. It is essential to check, track, and document the vast amounts of data and metadata that are generated during these analyses (and the relationships between them) in order to comply with regulations, support quality control, auditing, and reporting. It is, however, challenging, tedious, error-prone, and time-consuming, and diverts pharmacometricians from the more useful business of doing science. Automating this process would save time, reduce transcriptional errors, support the retention and transfer of knowledge, encourage good practice, and help ensure that pharmacometric analyses appropriately impact decisions...
May 15, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28501190/hplc-uv-and-hplc-cad-chromatographic-data-fusion-for-the-authentication-of-the-geographical-origin-of-palm-oil
#12
Kudirat Abidemi Obisesan, Ana M Jiménez-Carvelo, Luis Cuadros-Rodriguez, Itziar Ruisánchez, M Pilar Callao
Data fusion combined with a multivariate classification approach (partial least squares-discriminant analysis, PLS-DA) was applied to authenticate the geographical origin of palm oil. Data fusion takes advantage of the synergistic effect of information collected from more than one data source. In this study, data from liquid chromatography coupled to two detectors -ultraviolet (UV) and charged aerosol (CAD)- was fused by high- and mid-level data fusion strategies. Mid-level data fusion combines a few variables from each technique and then applies the classification technique...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28500546/quantitative-image-analysis-of-polyhydroxyalkanoates-inclusions-from-microbial-mixed-cultures-under-different-sbr-operation-strategies
#13
António L Amaral, Hugo Abreu, Cristiano Leal, Daniela P Mesquita, Luís M Castro, Eugénio C Ferreira
Polyhydroxyalkanoates (PHAs) produced from mixed microbial cultures (MMC), regarded as potential substitutes of petrochemical plastics, can be found as intracellular granules in various microorganisms under limited nutrient conditions and excess of carbon source. PHA is traditionally quantified by laborious and time-consuming chromatography analysis, and a simpler and faster method to assess PHA contents from MMC, such as quantitative image analysis (QIA), is of great interest. The main purpose of the present work was to upgrade a previously developed QIA methodology (as reported by Mesquita et al...
May 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28499205/comparative-metabolomics-analysis-for-the-compatibility-and-incompatibility-of-kansui-and-licorice-with-different-ratios-by-uhplc-qtof-ms-and-multivariate-data-analysis
#14
Juan Shen, Zong-Jin Pu, Jun Kai, An Kang, Yu-Ping Tang, Li-Li Shang, Gui-Sheng Zhou, Zhen-Hua Zhu, Er-Xin Shang, Shao-Ping Li, Yu-Jie Cao, Wei-Wei Tao, Shu-Lan Su, Li Zhang, Huiping Zhou, Da-Wei Qian, Jin-Ao Duan
Kansui, the root of Euphorbia kansui T.N. Liou ex T.P. Wang (Euphorbiaceae), is a well-known poisonous traditional Chinese medicine (TCM). However, many monographs of TCM indicated that it cannot be co-used with licorice, as kansui-licorice is a typical "eighteen incompatible" medicaments. Our previous studies have indicated that kansui was effective in treating malignant pleural effusion (MPE), and the efficacy could be weakened by the co-use of licorice, even causing serious toxicity at the given ratio. Nevertheless, the actual mechanisms of their dosage-toxicity-efficacy relationship need to be well clarified...
July 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28496467/interference-free-determination-of-carbamazepine-in-human-serum-using-high-performance-liquid-chromatography-a-comprehensive-research-with-three-way-calibration-methods
#15
Shiva Ghafghazi, Taraneh Moini Zanjani, Maryam Vosough, Masoumeh Sabetkasaei
In the present study, a comprehensive and systematic strategy was described to evaluate the performance of several three-way calibration methods on a bio-analytical problem. Parallel factor analysis (PARAFAC), alternating trilinear decomposition (ATLD), self-weighted alternating trilinear decomposition (SWATLD), alternating penalty trilinear decomposition (APTLD), and unfolded partial least squares combined with the residual bilinearization procedure (U-PLS/RBL) were applied on high performance liquid chromatography with photodiode-array detection (HPLC-DAD) data to quantify carbamazepine (CBZ) in different serum samples...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28496395/a-relative-quantitative-positive-negative-ion-switching-method-for-untargeted-lipidomics-via-high-resolution-lc-ms-ms-from-any-biological-source
#16
Susanne B Breitkopf, Stéphane J H Ricoult, Min Yuan, Ying Xu, David A Peake, Brendan D Manning, John M Asara
INTRODUCTION: Advances in high-resolution mass spectrometry have created renewed interest for studying global lipid biochemistry in disease and biological systems. OBJECTIVES: Here, we present an untargeted 30 min. LC-MS/MS platform that utilizes positive/negative polarity switching to perform unbiased data dependent acquisitions (DDA) via higher energy collisional dissociation (HCD) fragmentation to profile more than 1000-1500 lipid ions mainly from methyl-tert-butyl ether (MTBE) or chloroform:methanol extractions...
March 2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28496143/serum-metabolomic-profiles-for-breast-cancer-diagnosis-grading-and-staging-by-gas-chromatography-mass-spectrometry
#17
Naila Irum Hadi, Qamar Jamal, Ayesha Iqbal, Fouzia Shaikh, Saleem Somroo, Syed Ghulam Musharraf
Detection of metabolic signature for breast cancer (BC) has the potential to improve patient prognosis. This study identified potentially significant metabolites differentiating between breast cancer patients and healthy controls to help in diagnosis, grading, staging and determination of neoadjuvant status. Serum was collected from 152 pre-operative breast cancer (BC) patients and 155 healthy controls in this case-controlled study. Gas chromatography-mass spectrometry (GC-MS) was used to obtain metabolic profiles followed by chemometric analysis with the identification of significantly differentiated metabolites including 7 for diagnosis, 18 for grading, 23 for staging, 15 for stage III subcategory and 10 for neoadjuvant status (p-value < 0...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28495340/investigating-the-determinants-of-chinese-adult-children-s-intention-to-use-online-health-information-for-their-aged-parents
#18
Yukun Bao, Rakibul Hoque, Shiyu Wang
BACKGROUND: The increasing number of older people and the dissemination of health information via the Internet have emerged and both are challenging to Chinese society. Available online health information highlights the importance of decision making processes, specially in relation to the elderly who almost have no online presence and depend on their adult children's help. The researchers mostly focus on parents' health information search for their children, however, they overlook the adult children's intention to use online health information for their aged parents...
June 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28492493/hydration-fluid-intake-and-related-urine-biomarkers-among-male-college-students-in-cangzhou-china-a-cross-sectional-study-applications-for-assessing-fluid-intake-and-adequate-water-intake
#19
Na Zhang, Songming Du, Zhenchuang Tang, Mengqi Zheng, Ruixia Yan, Yitang Zhu, Guansheng Ma
The objectives of this study were to assess the associations between fluid intake and urine biomarkers and to determine daily total fluid intake for assessing hydration status for male college students. A total of 68 male college students aged 18-25 years recruited from Cangzhou, China completed a 7-day cross-sectional study. From day 1 to day 7; all subjects were asked to complete a self-administered 7-day 24-h fluid intake record. The foods eaten by subjects were weighed and 24-h urine was collected for three consecutive days on the last three consecutive days...
May 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28492480/detection-of-soil-nitrogen-using-near-infrared-sensors-based-on-soil-pretreatment-and-algorithms
#20
Pengcheng Nie, Tao Dong, Yong He, Fangfang Qu
Soil nitrogen content is one of the important growth nutrient parameters of crops. It is a prerequisite for scientific fertilization to accurately grasp soil nutrient information in precision agriculture. The information about nutrients such as nitrogen in the soil can be obtained quickly by using a near-infrared sensor. The data can be analyzed in the detection process, which is nondestructive and non-polluting. In order to investigate the effect of soil pretreatment on nitrogen content by near infrared sensor, 16 nitrogen concentrations were mixed with soil and the soil samples were divided into three groups with different pretreatment...
May 11, 2017: Sensors
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