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https://www.readbyqxmd.com/read/29143552/metabonomics-analysis-of-serum-from-rats-given-long-term-and-low-level-cadmium-by-ultra-performance-liquid-chromatography-mass-spectrometry
#1
Liyan Hu, Lu Bo, Meiyan Zhang, Siqi Li, Xiujuan Zhao, Changhao Sun
1. This study evaluated the toxicity of chronic exposure to low-level cadmium (Cd) in rats using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). Forty male Sprague-Dawley rats were randomly assigned to four groups, namely, the control group, low-dose group (0.13 mg/kg·bw), middle-dose group (0.8 mg/kg·bw) and high-dose group (4.89 mg/kg·bw). The rats continuously received CdCl2 via drinking water for 24 weeks. Serum samples were collected for metabonomics analysis. The data generated from the UPLC-MS was analysed using principal components analysis (PCA) and partial least-squares discriminant analysis (PLS-DA)...
November 16, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29142767/could-congenital-insensitivity-to-pain-with-anhidrosis-be-misdiagnosed-as-papillon-lef%C3%A3-vre-syndrome
#2
Mostafa Ibrahim Mostafa, Maha Rashed Abouzaid, Manal Micheal Thomas, Ghada Yousef El-Kamah
Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder characterized by early loss of teeth with hyperkeratosis of the palms and soles. Congenital insensitivity to pain with anhidrosis (CIPA) is a disorder of decreased pain sensation, decreased sweating, recurrent infections, and fever. Here, we report a 5-year-old girl born to consanguineous parents with a family history of a similarly affected sibling. The girl presented with early loss of teeth and palmoplantar hyperkeratosis, hence, provisionally diagnosed as PLS...
December 2017: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/29141132/intra-species-volatile-interactions-affects-growth-rates-and-exometabolomes-in-aspergillus-oryzae-kccm-60345
#3
Digar Singh, Choong Hwan Lee
The volatile organic compounds (VOCs) are increasingly been recognized as the chemical mediators of mold interactions shaping their community dynamic, growth, and metabolism. Herein, we selectively examined the time-correlated (0 D - 11 D) effects of intra-species VOCs mediated interactions (VMI) on Aspergillus oryzae KCCM 60345 (S1), following co-cultivation with partner strain A. oryzae KACC 44967 (S2), in specially designed twin plate assembly. The comparative evaluation of S1VMI (S1 subjected to VMI with S2) and its control (S1con) showed a notable disparity in their radial growth (S1VMI<S1con) at 5 D, protease activity (S1VMI>S1con) at 3-5 D, amylase activity (S1VMI<S1con) at 3-5 D, and antioxidant levels (S1VMI>S1con) at 3 D...
November 15, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29140387/full-mouth-rehabilitation-with-calvarium-bone-grafts-and-dental-implants-for-a-papillon-lef%C3%A3-vre-syndrome-patient-case-report
#4
Bassam M Kinaia, Kristyn Hope, Ahmed Zuhaili, Jean Francois Tulasne
Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder of keratinization associated with palmoplantar keratoderma and severe periodontitis resulting in complete edentulism in late adolescence. The pathognomonic dental features of PLS are pathologic migration, hypermobility, and exfoliation of the teeth without any signs of root resorption. It has been suggested that an effective way to treat PLS patients presenting early in the disease progression is extraction of the erupted primary dentition or hopeless permanent teeth followed by antibiotic coverage with periodontal therapy for the remaining teeth...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29137193/gas-measurement-using-static-fourier-transform-infrared-spectrometers
#5
Michael H Köhler, Michael Schardt, Markus S Rauscher, Alexander W Koch
Online monitoring of gases in industrial processes is an ambitious task due to adverse conditions such as mechanical vibrations and temperature fluctuations. Whereas conventional Fourier transform infrared (FTIR) spectrometers use rather complex optical and mechanical designs to ensure stable operation, static FTIR spectrometers do not require moving parts and thus offer inherent stability at comparatively low costs. Therefore, we present a novel, compact gas measurement system using a static single-mirror Fourier transform spectrometer (sSMFTS)...
November 13, 2017: Sensors
https://www.readbyqxmd.com/read/29136928/prediction-of-2-ehn-content-in-diesel-biodiesel-blends-using-ftir-and-chemometrics
#6
Dan Vrtiška, Pavel Šimáček
Quantification models based on the processing of FTIR spectra by partial least squares regression (PLS) were created in order to develop a method for the determination of 2-ethylhexyl nitrate (2-EHN) in diesel fuels. The set of standards was prepared using 2-EHN, biodiesel (FAME) and various mineral diesel fuels (2-EHN free). The standards were prepared in the concentration range of 2-EHN of 0-2436mgkg(-1). The set of the standards was divided into the calibration, validation and test sets. While the calibration set was used to build the model, validation set was used in order to optimize the model parameters...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136886/determination-of-terpenoid-contents-of-aromatic-plants-using-nirs
#7
Elif Ercioglu, Hasan Murat Velioglu, Ismail Hakki Boyaci
The method was developed in order to provide a fast, simple and non-destructive analysis of terpenoid compounds of aromatic plants. For this purpose, spectroscopic data were collected on the surface of dried plant samples by using near infrared spectroscopic (NIRS) analysis. Volatile substances were extracted from aromatic plants using hydro-distillation method to determine terpenoid composition by using gas chromatography-mass spectrometry (GC-MS). Multivariate calibration methods namely, partial least squares (PLS) regression, were used for data analysis...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136881/monitoring-of-tablet-coating-processes-with-colored-coatings
#8
Shirin Barimani, Peter Kleinebudde
Endpoints of coating processes for colored tablets were determined using in-line Raman spectroscopy. Coatings were performed with six commercially available formulations of pink, yellow, red, beige, green and blue color. The coatings were comprising pigments and/or dyes, some causing fluorescence and interfering the Raman signal. Using non-contact optics, a Raman probe was used as process analytical technology (PAT) tool, and acquired spectra were correlated to the sprayed mass of aqueous coating suspension...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136844/physicochemical-characterization-of-lavandula-spp-honey-with-ft-raman-spectroscopy
#9
Ofélia Anjos, António J A Santos, Vasco Paixão, Letícia M Estevinho
This study aimed to evaluate the potential of FT-Raman spectroscopy in the prediction of the chemical composition of Lavandula spp. monofloral honey. Partial Least Squares (PLS) regression models were performed for the quantitative estimation and the results were correlated with those obtained using reference methods. Good calibration models were obtained for electrical conductivity, ash, total acidity, pH, reducing sugars, hydroxymethylfurfural (HMF), proline, diastase index, apparent sucrose, total flavonoids content and total phenol content...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136819/alteration-in-the-liver-metabolome-of-rats-with-metabolic-syndrome-after-treatment-with-hydroxytyrosol-a-mass-spectrometry-and-nuclear-magnetic-resonance-based-metabolomics-study
#10
Ioanna Dagla, Dimitra Benaki, Eirini Baira, Nikolaos Lemonakis, Hemant Poudyal, Lindsay Brown, Anthony Tsarbopoulos, Alexios-Leandros Skaltsounis, Emmanouel Mikros, Evagelos Gikas
Metabolic syndrome (MetS) represents a group of abnormalities that enhances the risk for cardiovascular disease, diabetes and stroke. The Mediterranean diet seems to be an important dietary pattern, which reduces the incidence of MetS. Hydroxytyrosol (HT) - a simple phenol found in olive oil - has received increased attention for its antioxidant activity. Recently, the European Foods Safety Authority (EFSA) claimed that dietary consumption of HT exhibits a protective role against cardiovascular disease. In this study, an experimental protocol has been setup, including isolated HT administration in a diet induced model of MetS in young Wistar rats, in order to find out whether HT has a protective effect against MetS...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136810/prediction-of-parameters-related-to-grape-ripening-by-multivariate-calibration-of-voltammetric-signals-acquired-by-an-electronic-tongue
#11
L Pigani, G Vasile Simone, G Foca, A Ulrici, F Masino, L Cubillana-Aguilera, R Calvini, R Seeber
An electronic tongue (ET) consisting of two voltammetric sensors, namely a poly-ethylendioxythiophene modified Pt electrode and a sonogel carbon electrode, has been developed aiming at monitoring grape ripening. To test the effectiveness of device and measurement procedures developed, samples of three varieties of grapes have been collected from veraison to harvest of the mature grape bunches. The derived musts have been then submitted to electrochemical investigation using Differential Pulse Voltammetry technique...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136806/multivariate-analysis-of-organic-acids-in-fermented-food-from-reversed-phase-high-performance-liquid-chromatography-data
#12
Pablo Mortera, Federico A Zuljan, Christian Magni, Santiago A Bortolato, Sergio H Alarcón
Multivariate calibration coupled to RP-HPLC with diode array detection (HPLC-DAD) was applied to the identification and the quantitative evaluation of the short chain organic acids (malic, oxalic, formic, lactic, acetic, citric, pyruvic, succinic, tartaric, propionic and α-cetoglutaric) in fermented food. The goal of the present study was to get the successful resolution of a system in the combined occurrence of strongly coeluting peaks, of distortions in the time sensors among chromatograms, and of the presence of unexpected compounds not included in the calibration step...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136013/monomer-conversion-dimensional-stability-strength-modulus-surface-apatite-precipitation-and-wear-of-novel-reactive-calcium-phosphate-and-polylysine-containing-dental-composites
#13
Kanokrat Kangwankai, Sarah Sani, Piyaphong Panpisut, Wendy Xia, Paul Ashley, Haralampos Petridis, Anne Margaret Young
PURPOSE: The aim was to assess monomer conversion, dimensional stability, flexural strength / modulus, surface apatite precipitation and wear of mono / tri calcium phosphate (CaP) and polylysine (PLS)-containing dental composites. These were formulated using a new, high molecular weight, fluid monomer phase that requires no polymerisation activator. MATERIALS AND METHODS: Urethane and Polypropylene Glycol Dimethacrylates were combined with low levels of an adhesion promoting monomer and a light activated initiator...
2017: PloS One
https://www.readbyqxmd.com/read/29129869/fast-determination-of-biodiesel-content-in-commercial-diesel-biodiesel-blends-by-using-digital-images-and-multivariate-calibration
#14
Mayara Ferreira Barbosa, Danielle Silva DO Nascimento, Marcos Grünhut, Hebertty Vieira Dantas, Beatriz S Fernandez Band, Mario C Ugulino DE Araújo, Matías Insausti
A new simple, rapid and inexpensive analytical method was developed to determine the biodiesel percentage in biodiesel/diesel blends through simple digital images of samples obtained by scanning with a commercial scanner. Soybean biodiesel and petroleum diesel samples were acquired from refineries currently in operation. There were prepared several mixtures within the range 1.5 to 12.0% of biodiesel in diesel oil, using the same procedure as is done in industry. The analytical signals were images recorded with a scanner...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29129859/membrane-introduction-mass-spectrometry-combined-with-an-orthogonal-partial-least-squares-calibration-model-for-mixture-analysis
#15
Min Li, Lu Zhang, Xiaolong Yao, Xingyu Jiang
The emerging membrane introduction mass spectrometry technique has been successfully used to detect benzene, toluene, ethyl benzene and xylene (BTEX), while overlapped spectra have unfortunately hindered its further application to the analysis of mixtures. Multivariate calibration, an efficient method to analyze mixtures, has been widely applied. In this paper, we compared univariate and multivariate analyses for quantification of the individual components of mixture samples. The results showed that the univariate analysis creates poor models with regression coefficients of 0...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29127892/estimation-of-the-late-postmortem-interval-using-ftir-spectroscopy-and-chemometrics-in-human-skeletal-remains
#16
Qi Wang, Yinming Zhang, Hancheng Lin, Shuai Zha, Ruoxi Fang, Xin Wei, Shuanliang Fan, Zhenyuan Wang
Due to a lack of reliable and accurate methods, determining the postmortem interval (PMI) of human skeletal remains is one of the most important and challenging tasks in forensic medicine. In this paper, we studied the changes to bone chemistry with increasing PMI in two different experimental conditions using Fourier transform infrared (FTIR) spectroscopy in conjunction with chemometrics methods Paired bone samples collected from 56 human corpses were buried (placed in soil) and unburied (exposed to the air) for intervals between 76 and 552 days...
November 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29126478/optimization-of-gc-tof-ms-analysis-conditions-for-assessing-host-gut-microbiota-metabolic-interactions-chinese-rhubarb-alters-fecal-aromatic-amino-acids-and-phenol-metabolism
#17
Shan Yin, Pan Guo, Dafu Hai, Li Xu, Jiale Shu, Wenjin Zhang, Muhammad Idrees Khan, Irwin J Kurland, Yunping Qiu, Yumin Liu
In this paper, an optimized method based on gas chromatography/time-of-flight mass spectrometry (GC-TOFMS) platform has been developed for the analysis of gut microbial-host related co-metabolites in fecal samples. The optimization was performed with proportion of chloroform (C), methanol (M) and water (W) for the extraction of specific metabolic pathways of interest. Loading Bi-plots from the PLS regression model revealed that high concentration of chloroform emphasized the extraction of short chain fatty acids and TCA intermediates, while the higher concentration of methanol emphasized indole and phenyl derivatives...
December 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29124309/gain-of-function-of-tmem16e-ano5-scrambling-activity-caused-by-a-mutation-associated-with-gnathodiaphyseal-dysplasia
#18
Eleonora Di Zanni, Antonella Gradogna, Joachim Scholz-Starke, Anna Boccaccio
Mutations in the human TMEM16E (ANO5) gene are associated both with the bone disease gnathodiaphyseal dysplasia (GDD; OMIM: 166260) and muscle dystrophies (OMIM: 611307, 613319). However, the physiological function of TMEM16E has remained unclear. We show here that human TMEM16E, when overexpressed in mammalian cell lines, displayed partial plasma membrane localization and gave rise to phospholipid scrambling (PLS) as well as non-selective ionic currents with slow time-dependent activation at highly depolarized membrane potentials...
November 9, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29122720/connectome-based-predictive-modeling-of-attention-comparing-different-functional-connectivity-features-and-prediction-methods-across-datasets
#19
Kwangsun Yoo, Monica D Rosenberg, Wei-Ting Hsu, Sheng Zhang, Chiang-Shan R Li, Dustin Scheinost, R Todd Constable, Marvin M Chun
Connectome-based predictive modeling (CPM; Finn et al., 2015; Shen et al., 2017) was recently developed to predict individual differences in traits and behaviors, including fluid intelligence (Finn et al., 2015) and sustained attention (Rosenberg et al., 2016a), from functional brain connectivity (FC) measured with fMRI. Here, using the CPM framework, we compared the predictive power of three different measures of FC (Pearson's correlation, accordance, and discordance) and two different prediction algorithms (linear and partial least square [PLS] regression) for attention function...
November 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/29120765/rapid-and-sensitive-detection-of-pyrimethanil-residues-on-pome-fruits-by-surface-enhanced-raman-scattering
#20
L Mandrile, A M Giovannozzi, F Durbiano, G Martra, A M Rossi
Surface Enhanced Raman Scattering (SERS) supported by gold nanoparticles (AuNPs) was applied to detect and quantify residues of pyrimethanil on pome fruits, a widely used fungicide in horticultural species. Spheroidal AuNPs with different size were fabricated and compared in this study. The analytical procedure was set up on a silicon dioxide flat substrate to standardize SERS methodology. A Raman mapping strategy was exploited to increase signal reproducibility and to minimize bias due to different local surface morphologies...
April 1, 2018: Food Chemistry
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