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https://www.readbyqxmd.com/read/29351484/the-serum-metabolomics-signature-of-type-2-diabetes-is-obscured-in-alzheimer-s-disease
#1
Jill K Morris, Brian D Piccolo, Kartik Shankar, John P Thyfault, Sean H Adams
There is evidence for systemic metabolic impairment in Alzheimer's disease (AD), and Type 2 Diabetes (T2D) increases AD risk. Although studies analyzing blood metabolomics signatures have shown differences between cognitively healthy (CH) and AD subjects, these signatures have not been compared to individuals with T2D. We utilized untargeted analysis platforms (primary metabolism and complex lipids) to characterize the serum metabolome of 126 overnight fasted elderly subjects classified into 4 groups based upon AD status (CH or AD) and T2D status (Nondiabetic [ND] or T2D)...
December 26, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29349517/a-novel-genomic-signature-predicting-fdg-uptake-in-diverse-metastatic-tumors
#2
Aurora Crespo-Jara, Maria Carmen Redal-Peña, Elena Maria Martinez-Navarro, Manuel Sureda, Francisco Jose Fernandez-Morejon, Francisco J Garcia-Cases, Ramon Gonzalez Manzano, Antonio Brugarolas
BACKGROUND: Building a universal genomic signature predicting the intensity of FDG uptake in diverse metastatic tumors may allow us to understand better the biological processes underlying this phenomenon and their requirements of glucose uptake. METHODS: A balanced training set (n = 71) of metastatic tumors including some of the most frequent histologies, with matched PET/CT quantification measurements and whole human genome gene expression microarrays, was used to build the signature...
January 18, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29346784/surgical-treatment-and-chemotherapy-of-adult-primary-liver-sarcoma-experiences-from-a-single-hospital-in-china
#3
Feng Zhou, Han-Zhang Huang, Meng-Tao Zhou, Shao-Liang Han
BACKGROUND: The aim of this study is to improve the preoperative diagnostic accuracy and treatment results by investigating the clinical features and prognosis of primary liver sarcoma (PLS). METHODS: Clinical data, surgical treatments, adjuvant chemotherapy, and prognosis of 17 PLS patients whose diseases were pathologically confirmed were retrospectively analyzed. RESULTS: The main clinical symptoms included epigastric pain in 9 patients, epigastric distention in 7, and loss of appetite in 4; these symptoms were detected during the postoperative follow-up for gastric carcinoma in 1...
January 18, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29346328/comparison-of-svm-rf-and-elm-on-an-electronic-nose-for-the-intelligent-evaluation-of-paraffin-samples
#4
Hong Men, Songlin Fu, Jialin Yang, Meiqi Cheng, Yan Shi, Jingjing Liu
Paraffin odor intensity is an important quality indicator when a paraffin inspection is performed. Currently, paraffin odor level assessment is mainly dependent on an artificial sensory evaluation. In this paper, we developed a paraffin odor analysis system to classify and grade four kinds of paraffin samples. The original feature set was optimized using Principal Component Analysis (PCA) and Partial Least Squares (PLS). Support Vector Machine (SVM), Random Forest (RF), and Extreme Learning Machine (ELM) were applied to three different feature data sets for classification and level assessment of paraffin...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29345909/a-metabolomics-study-reveals-enhanced-inhibition-and-metabolic-dysregulation-in-e-coli-induced-by-lactobacillus-acidophilus-fermented-black-tea-extract
#5
Kundi Yang, Mattew Duley, Jiangjiang Zhu
This study examined the ability of Lactobacillus acidophilus (LA) to ferment black tea extract (BTE), and the enhancement of Escherichia coli cellular uptake of phenolic compounds when this bacteria was incubated with fermented BTE. The inhibitory effects of BTE to E. coli bacteria, with and w/o fermentation, were compared. Several intracellular phenolic compounds, as well as metabolic profiles of E. coli with and w/o treatments, were also determined using a HPLC-MS/MS-based approach. Our results showed that out of three concentrations from the non-fermented BTE treatment, only the extract from the 25 mg/ml tea leaves solution could inhibit E...
January 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29344361/platelet-protein-biomarker-panel-for-ovarian-cancer-diagnosis
#6
Marta Lomnytska, Rui Pinto, Susanne Becker, Ulla Engström, Sonja Gustafsson, Christina Björklund, Markus Templin, Jan Bergstrand, Lei Xu, Jerker Widengren, Elisabeth Epstein, Bo Franzén, Gert Auer
Background: Platelets support cancer growth and spread making platelet proteins candidates in the search for biomarkers. Methods: Two-dimensional (2D) gel electrophoresis, Partial Least Squares Discriminant Analysis (PLS-DA), Western blot, DigiWest. Results: PLS-DA of platelet protein expression in 2D gels suggested differences between the International Federation of Gynaecology and Obstetrics (FIGO) stages III-IV of ovarian cancer, compared to benign adnexal lesions with a sensitivity of 96% and a specificity of 88%...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29342096/high-resolution-lipidomics-of-the-early-life-stages-of-the-red-seaweed-porphyra-dioica
#7
Elisabete da Costa, Vitor Azevedo, Tânia Melo, Andreia M Rego, Dmitry V Evtuguin, Pedro Domingues, Ricardo Calado, Rui Pereira, Maria H Abreu, Maria R Domingues
Porphyra dioica is a commercial seaweed consumed all over the world, mostly in the shape of nori sheets used for "sushi" preparation. It is a well-known part of the Asian diet with health benefits, which have been associated, among others, to the high levels of n-3 and n-6 fatty acids in this red alga. However, other highly valued lipids of Porphyra are polar lipids that remain largely undescribed and can have both nutritional value and bioactivity, thus could contribute to the valorization of this seaweed...
January 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29341912/quantitative-estimation-of-phenytoin-sodium-disproportionation-in-the-formulations-using-vibration-spectroscopies-and-multivariate-methodologies
#8
Sathish Dharani, Ziyaur Rahman, Sogra F Barakh Ali, Hamideh Afrooz, Mansoor A Khan
Phenytoin sodium (PS) has tendency to convert to its base form; phenytoin base (PHT) during manufacturing, packaging, shelf life and in-use conditions that can influence its clinical performance. The objective of the present work was to develop a non-destructive, quick and easy analytical method for quantification of PHT in the drug product. A formulation was prepared containing the excipients present in the commercial capsule formulation of PS. Formulation containing either 100% PHT or PS was prepared and these formulations were mixed in different proportion to achieve 0-100% PHT matrices...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29337562/physiologically-based-pharmacokinetic-modeling-in-lead-optimization-ii-rational-bioavailability-design-by-global-sensitivity-analysis-to-identify-properties-affecting-bioavailability
#9
Pankaj R Daga, Michael B Bolger, Ian Haworth, Robert Daniel Clark, Eric J Martin
When medicinal chemists need to improve oral bioavailability (%F) during lead optimization, they systematically modify compound properties mainly based on their own experience and general rules of thumb. However, at least a dozen properties can influence %F, and the difficulty of multi-parameter optimization for such complex non-linear processes grows combinatorially with the number of variables. Furthermore, strategies can be in conflict. For example, adding a polar or charged group will generally increase solubility but decrease permeability...
January 16, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29337283/variability-studies-of-allochthonous-stone-pine-pinus-pinea-l-plantations-in-chile-through-nut-protein-profiling
#10
V Loewe, R M Navarro-Cerrillo, R Sánchez Lucas, F J Ruiz Gómez, J Jorrín-Novo
Stone pine (Pinus pinea) is characterized by low differentiation of growth parameters, high phenotypic plasticity and low genetic variability; detecting its diversity in introduced Chilean populations is therefore relevant for conservation and breeding programs. Here, variability among allochthonous Stone pine populations in Chile was explored using electrophoresis-based proteomic analysis of pine nuts. Cones from 30 populations distributed along a climatic gradient in Chile were surveyed and sampled, and proteins were extracted from seed flour using the TCA-acetone precipitation protocol...
January 11, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29337053/oral-ingestion-of-plasmalogens-can-attenuate-the-lps-induced-memory-loss-and-microglial-activation
#11
Md Shamim Hossain, Ayako Tajima, Satoshi Kotoura, Toshihiko Katafuchi
Plasmalogens (Pls) are the special phospholipids which were reported to be reduced in brain and blood samples of Alzheimer's disease (AD) patients, suggested a possibility that an oral ingestion of Pls may prevent the disease progression. Interestingly, the clinical study showed that the daily oral ingestion of Pls among the mild AD patients improved cognition. However, it is unknown of whether the oral ingestion of Pls inhibits the AD like changes in brain e.g., glial activation and accumulation of amyloid beta (Aβ) proteins...
January 11, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29332795/polymer-based-materials-modified-with-magnetite-nanoparticles-for-enrichment-of-phospholipids
#12
I Ten-Doménech, H Martínez-Pérez-Cejuela, E F Simó-Alfonso, S Torres-Cartas, S Meseguer-Lloret, J M Herrero-Martínez
A polymeric material modified with magnetic nanoparticles (MNPs) has been synthesized and evaluated as sorbent both for solid-phase extraction (SPE) and dispersive magnetic solid-phase extraction (MSPE) of phospholipids (PLs) in human milk samples. The synthesized sorbent was characterized by scanning electron microscopy and its iron content was also determined. Several experimental variables that affect the extraction performance (e.g. loading solvent, breakthrough volume and loading capacity) were investigated and a comparison between conventional SPE and MSPE modalities was done...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29331819/new-strategy-for-determination-of-anthocyanins-polyphenols-and-antioxidant-capacity-of-brassica-oleracea-liquid-extract-using-infrared-spectroscopies-and-multivariate-regression
#13
Isadora R N de Oliveira, Jussara V Roque, Mariza P Maia, Paulo C Stringheta, Reinaldo F Teófilo
A new method was developed to determine the antioxidant properties of red cabbage extract (Brassica oleracea) by mid (MID) and near (NIR) infrared spectroscopies and partial least squares (PLS) regression. A 70% (v/v) ethanolic extract of red cabbage was concentrated to 9° Brix and further diluted (12 to 100%) in water. The dilutions were used as external standards for the building of PLS models. For the first time, this strategy was applied for building multivariate regression models. Reference analyses and spectral data were obtained from diluted extracts...
January 4, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29331815/chemometric-simultaneous-determination-of-sofosbuvir-and-ledipasvir-in-pharmaceutical-dosage-form
#14
Mahsa Khalili, Mahmoud Reza Sohrabi, Vahid Mirzabeygi, Nahid Torabi Ziaratgahi
Partial least squares (PLS), different families of continuous wavelet transform (CWT), and first derivative spectrophotometry (DS) techniques were studied for quantification of Sofosbuvir (SFB) and Ledipasvir (LDV) simultaneously without separation step. The components were dissolved in Acetonitrile and the spectral behaviors were evaluated in the range of 200 to 400nm. The ultraviolet (UV) absorbance of LDV exhibits no interferences between 300 and 400nm and it was decided to predict the LDV amount through the classic spectrophotometry (CS) method in this spectral region as well...
January 6, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29331813/comparative-study-of-the-efficiency-of-computed-univariate-and-multivariate-methods-for-the-estimation-of-the-binary-mixture-of-clotrimazole-and-dexamethasone-using-two-different-spectral-regions
#15
Yasmin Mohammed Fayez, Shereen Mostafa Tawakkol, Nesma Mahmoud Fahmy, Hayam Mahmoud Lotfy, Mostafa Abdel-Aty Shehata
Three methods of analysis are conducted that need computational procedures by the Matlab® software. The first is the univariate mean centering method which eliminates the interfering signal of the one component at a selected wave length leaving the amplitude measured to represent the component of interest only. The other two multivariate methods named PLS and PCR depend on a large number of variables that lead to extraction of the maximum amount of information required to determine the component of interest in the presence of the other...
January 9, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29331073/cerebrospinal-fluid-macrophage-biomarkers-in-amyotrophic-lateral-sclerosis
#16
A G Thompson, E Gray, M-L Thézénas, P D Charles, S Evetts, M T Hu, K Talbot, R Fischer, B M Kessler, M R Turner
Objective The neurodegenerative disease amyotrophic lateral sclerosis (ALS) is a heterogeneous clinical syndrome involving multiple molecular pathways. The development of biomarkers for use in therapeutic trials is a priority. We sought to use a high-throughput proteomic method to identify novel biomarkers in individual cerebrospinal fluid samples. Methods Liquid chromatography-tandem mass spectrometry with label-free quantification was used to identify cerebrospinal fluid proteins using samples from a well-characterised longitudinal cohort comprising patients with ALS (n=43), the upper motor neuron variant primary lateral sclerosis (PLS, n=6), cross-sectional healthy (n=20) and disease controls (Parkinsons's n=20, ALS mimic disorders n=12)...
January 13, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29330958/do-muscles-constrain-skull-shape-evolution-in-strepsirrhines
#17
Anne-Claire Fabre, Jonathan M G Perry, Adam Hartstone-Rose, AuróLien Lowie, Andy Boens, MaÏtena Dumont
Despite great interest and decades of research, the musculoskeletal relationships of the masticatory system in primates are still not fully understood. However, without a clear understanding of the interplay between muscles and bones it remains difficult to understand the functional significance of morphological traits of the skeleton. Here, we aim to study the impacts of the masticatory muscles on the shape of the cranium and the mandible as well as their co-variation in strepsirrhine primates. To do so, we use 3D geometric morphometric approaches to assess the shape of each bone of the skull of 20 species for which muscle data are available in the literature...
February 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29330539/missing-value-imputation-approach-for-mass-spectrometry-based-metabolomics-data
#18
Runmin Wei, Jingye Wang, Mingming Su, Erik Jia, Shaoqiu Chen, Tianlu Chen, Yan Ni
Missing values exist widely in mass-spectrometry (MS) based metabolomics data. Various methods have been applied for handling missing values, but the selection can significantly affect following data analyses. Typically, there are three types of missing values, missing not at random (MNAR), missing at random (MAR), and missing completely at random (MCAR). Our study comprehensively compared eight imputation methods (zero, half minimum (HM), mean, median, random forest (RF), singular value decomposition (SVD), k-nearest neighbors (kNN), and quantile regression imputation of left-censored data (QRILC)) for different types of missing values using four metabolomics datasets...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329850/gc-ms-profiling-descriptive-sensory-analysis-and-consumer-acceptance-of-costa-rican-papaya-carica-papaya-l-fruit-purees
#19
Veronika M Lieb, Patricia Esquivel, Elba Cubero Castillo, Reinhold Carle, Christof B Steingass
Volatiles of papaya purees from four Costa Rican cultivars were analysed by solid-phase microextraction and gas chromatography-mass spectrometry. A total of 83 volatiles was assigned in the purees, of which 19 were detected for the first time as papaya constituents. As revealed by multivariate statistics, i.e., principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA), the purees may be allocated to terpene- and lactone-rich ('SH-5'), ester-containing ('Criolla'), and intermediate chemotypes ('Pococí' and 'Silvestre')...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29322934/computational-analysis-reveals-the-coupling-between-bistability-and-the-sign-of-a-feedback-loop-in-a-tgf-%C3%AE-1-activation-model
#20
Huipeng Li, Lakshmi Venkatraman, Balakrishnan Chakrapani Narmada, Jacob K White, Hanry Yu, Lisa Tucker-Kellogg
BACKGROUND: Bistable behaviors are prevalent in cell signaling and can be modeled by ordinary differential equations (ODEs) with kinetic parameters. A bistable switch has recently been found to regulate the activation of transforming growth factor-β1 (TGF-β1) in the context of liver fibrosis, and an ordinary differential equation (ODE) model was published showing that the net activation of TGF-β1 depends on the balance between two antagonistic sub-pathways. RESULTS: Through modeling the effects of perturbations that affect both sub-pathways, we revealed that bistability is coupled with the signs of feedback loops in the model...
December 21, 2017: BMC Systems Biology
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